{"id":5171,"date":"2024-01-16T11:01:40","date_gmt":"2024-01-16T11:01:40","guid":{"rendered":"https:\/\/farlong.com\/?p=5171"},"modified":"2024-01-27T10:30:11","modified_gmt":"2024-01-27T10:30:11","slug":"research-progress-on-pyroptosis-mediated-immune-inflammatory-response-in-ischemic-stroke-and-the-role-of-natural-plant-components-as-regulator-of-pyroptosis-a-review","status":"publish","type":"post","link":"https:\/\/directcm.com\/es\/research-progress-on-pyroptosis-mediated-immune-inflammatory-response-in-ischemic-stroke-and-the-role-of-natural-plant-components-as-regulator-of-pyroptosis-a-review\/","title":{"rendered":"Avances de la investigaci\u00f3n sobre la respuesta inmunoinflamatoria mediada por piroptosis en el accidente cerebrovascular isqu\u00e9mico y el papel de los componentes naturales de las plantas como reguladores de la piroptosis: una revisi\u00f3n"},"content":{"rendered":"<div id=\"ab0015\" class=\"abstract author-highlights\">\n<h2 class=\"section-title u-h4 u-margin-l-top u-margin-xs-bottom\">Reflejos<\/h2>\n<div id=\"abs0015\">\n<ul>\n<li id=\"p0005\">Esta revisi\u00f3n resumi\u00f3 el \u00faltimo mecanismo molecular de la piroptosis en el accidente cerebrovascular isqu\u00e9mico.<\/li>\n<li id=\"p0010\">Esta revisi\u00f3n resume el papel de los componentes naturales de las plantas como regulador de la piroptosis en el accidente cerebrovascular isqu\u00e9mico.<\/li>\n<li id=\"p0015\">La regulaci\u00f3n de la piroptosis en el ictus isqu\u00e9mico se propone como una posible estrategia terap\u00e9utica.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div id=\"ab0010\" class=\"abstract author\"><\/p>\n<h2><\/h2>\n<h2 class=\"section-title u-h4 u-margin-l-top u-margin-xs-bottom\">Abstracto<\/h2>\n<div id=\"abs0010\">\n<p id=\"sp0030\"><a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el accidente cerebrovascular isqu\u00e9mico en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/brain-ischemia\">Accidente cerebrovascular isqu\u00e9mico<\/a>\u00a0(IS) es una de las principales causas de muerte y discapacidad. Su patogenia no est\u00e1 del todo clara, siendo la cascada inflamatoria una de sus principales\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los procesos patol\u00f3gicos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathological-process\">procesos patol\u00f3gicos<\/a>. La pr\u00e1ctica cl\u00ednica actual del IS es restaurar la\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el suministro de sangre en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascularity\">suministro de sangre<\/a>\u00a0al \u00e1rea isqu\u00e9mica despu\u00e9s de IS lo antes posible a trav\u00e9s de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la terapia trombol\u00edtica en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/fibrinolytic-therapy\">terapia trombol\u00edtica<\/a>\u00a0para proteger la vitalidad y funci\u00f3n de las neuronas. Sin embargo, la reperfusi\u00f3n sangu\u00ednea acelera a\u00fan m\u00e1s el da\u00f1o isqu\u00e9mico y provoca una lesi\u00f3n por isquemia-reperfusi\u00f3n. El proceso patol\u00f3gico de la lesi\u00f3n por isquemia-reperfusi\u00f3n cerebral implica m\u00faltiples mecanismos y el mecanismo exacto no se ha dilucidado por completo.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la piroptosis en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyroptosis\">Piroptosis<\/a>, una forma recientemente descubierta de inflamaci\u00f3n\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la muerte celular programada en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/programmed-cell-death\">muerte celular programada<\/a>, juega un papel importante en el inicio y la progresi\u00f3n de la inflamaci\u00f3n. Es una muerte programada proinflamatoria mediada por\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la caspasa en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/caspase\">caspasa<\/a>\u00a0Caspasa-1\/4\/5\/11, que puede provocar inflamaci\u00f3n y ruptura celular, liberar factores inflamatorios IL-1\u03b2 e IL-18 e inducir una cascada inflamatoria. Estudios recientes han demostrado que la piroptosis y su respuesta inflamatoria mediada son factores importantes que agravan la lesi\u00f3n cerebral isqu\u00e9mica, y la inhibici\u00f3n de la piroptosis puede aliviar la lesi\u00f3n cerebral isqu\u00e9mica. Adem\u00e1s, los estudios han encontrado que los componentes naturales de las plantas pueden tener un efecto regulador sobre la piroptosis. Por lo tanto, esta revisi\u00f3n no s\u00f3lo resume el mecanismo molecular de la piroptosis y su papel en el accidente cerebrovascular isqu\u00e9mico, sino tambi\u00e9n el papel de los componentes naturales de las plantas como regulador de la piroptosis, con el fin de proporcionar informaci\u00f3n de referencia sobre la piroptosis para el\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el tratamiento en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/therapeutic-procedure\">tratamiento<\/a>\u00a0del EI en el futuro.<\/p>\n<div class=\"Keywords u-font-serif text-s\">\n<div id=\"keys0005\" class=\"keywords-section\">\n<h2 class=\"section-title u-h4 u-margin-l-top u-margin-xs-bottom\">Palabras clave<\/h2>\n<div id=\"key0005\" class=\"keyword\">Piroptosis; Accidente cerebrovascular isqu\u00e9mico; caspasas; Componentes vegetales naturales; inflamasoma<\/div>\n<\/div>\n<\/div>\n<div id=\"body\" class=\"Body u-font-serif text-s\">\n<div>\n<section id=\"sec0005\">\n<h2 id=\"sect0025\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">1. Introducci\u00f3n<\/h2>\n<p id=\"p0025\">Con el envejecimiento de la poblaci\u00f3n mundial, la incidencia de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la enfermedad cerebrovascular en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebrovascular-disease\">enfermedad cerebrovascular<\/a>\u00a0(como el accidente cerebrovascular) se ha convertido en el segundo m\u00e1s grande del mundo, y la amenaza para los seres humanos est\u00e1 aumentando\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib1\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib1\"><span class=\"anchor-text\">[1]<\/span><\/a>. El accidente cerebrovascular incluye\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el accidente cerebrovascular isqu\u00e9mico en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/brain-ischemia\">accidente cerebrovascular isqu\u00e9mico<\/a>\u00a0(Es y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el accidente cerebrovascular hemorr\u00e1gico en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebral-hemorrhage\">ataque hemorragico<\/a>, y hasta 87% de accidentes cerebrovasculares son isqu\u00e9micos\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib2\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib2\"><span class=\"anchor-text\">[2]<\/span><\/a>. El IS es una emergencia cl\u00ednica com\u00fan y su incidencia aumenta a\u00f1o tras a\u00f1o. La pr\u00e1ctica cl\u00ednica actual del IS es restaurar la\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el suministro de sangre en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascularity\">suministro de sangre<\/a>\u00a0al \u00e1rea isqu\u00e9mica despu\u00e9s de IS lo antes posible a trav\u00e9s de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la terapia trombol\u00edtica en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/fibrinolytic-therapy\">terapia trombol\u00edtica<\/a>\u00a0para proteger la vitalidad y funci\u00f3n de las neuronas\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib3\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib3\"><span class=\"anchor-text\">[3]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib4\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib4\"><span class=\"anchor-text\">[4]<\/span><\/a>. Sin embargo, la lesi\u00f3n por isquemia-reperfusi\u00f3n (IRI) despu\u00e9s de la restauraci\u00f3n del flujo sangu\u00edneo a menudo causa da\u00f1os m\u00e1s graves a\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el tejido cerebral en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-tissue\">tejido cerebral<\/a>\u00a0y las c\u00e9lulas nerviosas, lo que adem\u00e1s se convierte en un factor importante que conduce a un mal pron\u00f3stico y disfunci\u00f3n de los pacientes.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib5\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib5\"><span class=\"anchor-text\">[5]<\/span><\/a>. La encuesta epidemiol\u00f3gica mundial analiz\u00f3 datos de 1990 a 2019 en 204 pa\u00edses y regiones de todo el mundo. Su informe afirma que el accidente cerebrovascular sigue siendo la segunda causa de muerte (11,61 TP3T del total de muertes) y la tercera causa de muerte y discapacidad [5,71 TP3T del total de muertes].\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los a\u00f1os de vida ajustados por discapacidad en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/disability-adjusted-life-years\">A\u00f1os de vida ajustados por discapacidad<\/a>\u00a0(AVAD)], que ocupa el segundo lugar despu\u00e9s\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las enfermedades neonatales en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/newborn-disease\">enfermedad neonatal<\/a>\u00a0(7,31 AVAD TP3T) y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la cardiopat\u00eda isqu\u00e9mica en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemic-heart-disease\">enfermedad isqu\u00e9mica del coraz\u00f3n<\/a>\u00a0(7,21 AVAD TP3T), y el n\u00famero de pacientes con accidente cerebrovascular sigue aumentando\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib6\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib6\"><span class=\"anchor-text\">[6]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib7\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib7\"><span class=\"anchor-text\">[7]<\/span><\/a>, especialmente en China. China se ha convertido en el pa\u00eds con mayor riesgo de accidente cerebrovascular del mundo: el riesgo de accidente cerebrovascular entre los residentes alcanza los 39,31 TP3T, y el riesgo de accidente cerebrovascular entre los hombres chinos tambi\u00e9n es el m\u00e1s alto entre los hombres del mundo, superando los 411 TP3T; El EI ha pasado de ser la tercera causa de muerte (en 1990) a la primera (en 2017) entre los residentes chinos.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib8\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib8\"><span class=\"anchor-text\">[8]<\/span><\/a>. Los estudios actuales sugieren que los mecanismos patol\u00f3gicos de la IRI cerebral (CIRI) son principalmente\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el estr\u00e9s oxidativo en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/oxidative-stress\">estr\u00e9s oxidativo<\/a>\u00a0lesi\u00f3n,\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las lesiones inflamatorias en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammatory-injury\">lesi\u00f3n inflamatoria<\/a>, lesi\u00f3n mitocondrial, autofagia y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la apoptosis en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/programmed-cell-death\">apoptosis<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib9\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib9\"><span class=\"anchor-text\">[9]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib10\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib10\"><span class=\"anchor-text\">[10]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib11\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib11\"><span class=\"anchor-text\">[11]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib12\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib12\"><span class=\"anchor-text\">[12]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib13\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib13\"><span class=\"anchor-text\">[13]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib14\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib14\"><span class=\"anchor-text\">[14]<\/span><\/a>. Sin embargo, estos todav\u00eda son insuficientes para explicar el mecanismo patol\u00f3gico de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre CIRI en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunoreactive-insulin\">CIRI<\/a>. Por ejemplo, se cree que la muerte neuronal despu\u00e9s de CIRI es causada principalmente por apoptosis, y la direcci\u00f3n de la protecci\u00f3n de las c\u00e9lulas neuronales es principalmente antiapoptosis. Sin embargo, la apoptosis no est\u00e1 directamente relacionada con la inflamaci\u00f3n.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib15\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib15\"><span class=\"anchor-text\">[15]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib16\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib16\"><span class=\"anchor-text\">[16]<\/span><\/a>, pero hay una respuesta inflamatoria sustancial en CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib16\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib16\"><span class=\"anchor-text\">[16]<\/span><\/a>. Por lo tanto, es necesario aclarar m\u00e1s el mecanismo fisiopatol\u00f3gico del IS y explorar m\u00e1s a fondo la etiolog\u00eda de la CIRI.<\/p>\n<p id=\"p0030\"><a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la piroptosis en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyroptosis\">Piroptosis<\/a>, tambi\u00e9n conocido como\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la inflamaci\u00f3n celular en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammatory-cell\">inflamatorio celular<\/a>\u00a0La necrosis, es una muerte celular programada recientemente descubierta y confirmada en los \u00faltimos a\u00f1os.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib17\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib17\"><span class=\"anchor-text\">[17]<\/span><\/a>. La piroptosis depende de la inflamaci\u00f3n.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las caspasas en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/caspase\">caspasas<\/a>\u00a0(principalmente caspasa-1, 4, 5, 11) y se acompa\u00f1a de la liberaci\u00f3n de una gran cantidad de factores proinflamatorios. Se manifiesta por la continua expansi\u00f3n de las c\u00e9lulas hasta que la c\u00e9lula\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las roturas de membranas en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/membrane-rupture\">roturas de membrana<\/a>, lo que resulta en la liberaci\u00f3n del contenido celular y la activaci\u00f3n de una fuerte respuesta inflamatoria.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib17\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib17\"><span class=\"anchor-text\">[17]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib18\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib18\"><span class=\"anchor-text\">[18]<\/span><\/a>. El\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las caracter\u00edsticas morfol\u00f3gicas en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/morphological-trait\">caracter\u00edsticas morfol\u00f3gicas<\/a>, la aparici\u00f3n y el mecanismo regulador de la piroptosis son diferentes de otros m\u00e9todos de muerte celular como la apoptosis y la necrosis.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib18\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib18\"><span class=\"anchor-text\">[18]<\/span><\/a>. La piroptosis est\u00e1 ampliamente involucrada en la aparici\u00f3n y desarrollo de diversas enfermedades, como enfermedades infecciosas, enfermedades relacionadas con el sistema nervioso, enfermedades ateroscler\u00f3ticas y tumores malignos.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib19\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib19\"><span class=\"anchor-text\">[19]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib20\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib20\"><span class=\"anchor-text\">[20]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib21\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib21\"><span class=\"anchor-text\">[21]<\/span><\/a>. Los \u00faltimos estudios muestran que la piroptosis y su respuesta inflamatoria mediada est\u00e1n implicadas en la\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el proceso patol\u00f3gico en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathological-process\">proceso patologico<\/a>\u00a0de IS, y prevenir la activaci\u00f3n de la piroptosis es beneficioso para inhibir la cascada inflamatoria y reducir la lesi\u00f3n cerebral isqu\u00e9mica\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib22\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib22\"><span class=\"anchor-text\">[22]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib23\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib23\"><span class=\"anchor-text\">[23]<\/span><\/a>. En base a esto, el estudio de la piroptosis es crucial para la\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el tratamiento en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/therapeutic-procedure\">tratamiento<\/a>\u00a0del EI; La regulaci\u00f3n de la piroptosis puede reducir la tasa de mortalidad del IS, mejorar la tasa de supervivencia de las neuronas y mejorar los s\u00edntomas de los pacientes con IS. Actualmente,\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los medicamentos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chemotherapeutic-agent\">drogas<\/a>\u00a0que ejercen\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre neuroprotectores en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroprotective-agent\">neuroprotector<\/a>\u00a0Se est\u00e1n desarrollando efectos mediante la regulaci\u00f3n de la v\u00eda de piroptosis. En particular, existen muchos estudios sobre los componentes naturales de las plantas que regulan la piroptosis de las unidades neuronales vasculares en el IS. Nuestros estudios anteriores tambi\u00e9n demostraron que\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las saponinas en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/saponin\">saponinas<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib24\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib24\"><span class=\"anchor-text\">[24]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib25\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib25\"><span class=\"anchor-text\">[25]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib26\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib26\"><span class=\"anchor-text\">[26]<\/span><\/a>\u00a0y compuestos multicomponentes\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib27\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib27\"><span class=\"anchor-text\">[27]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib28\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib28\"><span class=\"anchor-text\">[28]<\/span><\/a>\u00a0puede regular el\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los procesos biol\u00f3gicos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/biological-phenomena-and-functions-concerning-the-entire-organism\">proceso biol\u00f3gico<\/a>\u00a0de piroptosis en IS. Por lo tanto, esta revisi\u00f3n no solo resume el mecanismo molecular de la piroptosis y su papel en el accidente cerebrovascular isqu\u00e9mico, sino tambi\u00e9n el papel de los componentes naturales de las plantas como reguladores de la piroptosis para proporcionar compuestos l\u00edderes o componentes naturales de las plantas para el futuro desarrollo de f\u00e1rmacos relacionados con la piroptosis.<\/p>\n<\/section>\n<section id=\"sec0010\">\n<h2 id=\"sect0030\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">2. piroptosis<\/h2>\n<section id=\"sec0015\">\n<h3 id=\"sect0035\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.1. Las caracter\u00edsticas de la piroptosis.<\/h3>\n<div>\n<p id=\"p0035\"><a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la piroptosis en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyroptosis\">Piroptosis<\/a>\u00a0es una forma de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la muerte celular programada en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/programmed-cell-death\">muerte celular programada<\/a>\u00a0dependiente de proinflamatorios\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las caspasas en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/caspase\">caspasas<\/a>, que se caracteriza por la formaci\u00f3n de poros transmembrana, hinchaz\u00f3n y rotura de las membranas celulares y liberaci\u00f3n de contenidos proinflamatorios.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib29\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib29\"><span class=\"anchor-text\">[29]<\/span><\/a>. En el proceso de apoptosis, las c\u00e9lulas tienen fragmentaci\u00f3n nuclear e integridad de la membrana celular, lo que no causa respuesta inflamatoria en los tejidos circundantes, mientras que las c\u00e9lulas en el proceso de piroptosis tienen una morfolog\u00eda nuclear completa y una c\u00e9lula.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la rotura de membranas en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/membrane-rupture\">ruptura de membrana<\/a>, que causa inflamaci\u00f3n perif\u00e9rica\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib30\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib30\"><span class=\"anchor-text\">[30]<\/span><\/a>. Cuando se produce piroptosis, la membrana celular se romper\u00e1 gradualmente para formar poros de la membrana celular de 1 a 2 nm, y luego el contenido celular, como los factores inflamatorios intracelulares y otras sustancias, se liberan fuera de la membrana celular. Colorantes que penetran la membrana, como\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el bromuro de etidio en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ethidium-bromide\">bromuro de etidio<\/a>\u00a0Se puede utilizar para observar si las c\u00e9lulas sufren piroptosis.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib31\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib31\"><span class=\"anchor-text\">[31]<\/span><\/a>. Adem\u00e1s, la aparici\u00f3n de necrosis depende de la serie mixta similar a la prote\u00edna quinasa.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la prote\u00edna de dominio en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/protein-domain\">prote\u00edna de dominio<\/a>\u00a0(MLKL), que es selectivo para los iones que ingresan a la c\u00e9lula, y la cromatina nuclear es floculenta o tiene bordes agrupados. La piroptosis depende de la prote\u00edna formadora de poros GSDMD, una prote\u00edna no selectiva que causa la inflamaci\u00f3n nuclear.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la picnosis en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyknosis\">picnosis<\/a>\u00a0y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la fragmentaci\u00f3n del ADN en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/dna-fragmentation\">fragmentaci\u00f3n del ADN<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib32\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib32\"><span class=\"anchor-text\">[32]<\/span><\/a>. Existen similitudes y diferencias entre piroptosis, apoptosis, necroptosis y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la ferroptosis en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ferroptosis\">ferroptosis<\/a>, como la causa, los cambios celulares, etc. Los detalles se muestran en\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#tbl0005\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"tbl0005\"><span class=\"anchor-text\">tabla 1<\/span><\/a>.<\/p>\n<div id=\"tbl0005\" class=\"tables colsep-0 rowsep-0 frame-topbot\">\n<p id=\"sp0020\"><span class=\"label\">tabla 1<\/span>. Similitudes y diferencias entre piroptosis, apoptosis y necroptosis.<\/p>\n<div class=\"groups\">\n<table>\n<thead>\n<tr class=\"rowsep-1\">\n<th scope=\"col\">Caracter\u00edsticas<\/th>\n<th scope=\"col\">Componentes de firma<\/th>\n<th scope=\"col\">Cambios en las c\u00e9lulas.<\/th>\n<th scope=\"col\">causa general<\/th>\n<th scope=\"col\">Inhibidores<\/th>\n<th scope=\"col\">Referencia<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<th scope=\"row\">Piroptosis<\/th>\n<td>Piroptosoma, inflamasoma<\/td>\n<td>Formaci\u00f3n de poros, hinchaz\u00f3n celular, rotura de membrana plasm\u00e1tica, condensaci\u00f3n de cromatina, fragmentaci\u00f3n del ADN pero integridad nuclear, etc.<\/td>\n<td>HUMEDAD, PAMP, infecci\u00f3n<\/td>\n<td>Inhibidores de GSDMD<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib19\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib19\"><span class=\"anchor-text\">[19]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib33\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib33\"><span class=\"anchor-text\">[33]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib34\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib34\"><span class=\"anchor-text\">[34]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib35\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib35\"><span class=\"anchor-text\">[35]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib36\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib36\"><span class=\"anchor-text\">[36]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">apoptosis<\/th>\n<td>apoptosoma<\/td>\n<td>La c\u00e9lula se encoge con la membrana intacta, formaci\u00f3n de burbujas en la membrana plasm\u00e1tica, condensaci\u00f3n de cromatina, fragmentaci\u00f3n del ADN, etc.<\/td>\n<td>Regulaci\u00f3n gen\u00e9tica de estados fisiol\u00f3gicos.<\/td>\n<td>Familia de caspasas reguladoras, familia Bcl-2, p53, etc.<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib37\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib37\"><span class=\"anchor-text\">[37]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib38\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib38\"><span class=\"anchor-text\">[38]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib39\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib39\"><span class=\"anchor-text\">[39]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">necroptosis<\/th>\n<td>Necrosoma<\/td>\n<td>Hinchaz\u00f3n celular, rotura de membrana plasm\u00e1tica, hinchaz\u00f3n de org\u00e1nulos, condensaci\u00f3n de cromatina, etc.<\/td>\n<td>Herida grave<\/td>\n<td>Nec-1, NSA, etc.<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib33\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib33\"><span class=\"anchor-text\">[33]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib40\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib40\"><span class=\"anchor-text\">[40]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib41\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib41\"><span class=\"anchor-text\">[41]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib42\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib42\"><span class=\"anchor-text\">[42]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib43\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib43\"><span class=\"anchor-text\">[43]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Ferroptosis<\/th>\n<td>NRF2, GPX4, ACSL4, etc.<\/td>\n<td>Ocurre principalmente en las mitocondrias, con crestas mitocondriales reducidas, membranas condensadas y membranas externas rotas.<\/td>\n<td>Sobrecarga de Fe2+ y ROS<\/td>\n<td>GSH, deferoxamina, liproxstatina-1, ferrostatina-1, etc.<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib44\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib44\"><span class=\"anchor-text\">[44]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib45\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib45\"><span class=\"anchor-text\">[45]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib46\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib46\"><span class=\"anchor-text\">[46]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib47\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib47\"><span class=\"anchor-text\">[47]<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section id=\"sec0020\">\n<h3 id=\"sect0040\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.2. El mecanismo molecular de la piroptosis.<\/h3>\n<p id=\"p0040\">La formacion de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el inflamasoma en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammasome\">inflamasoma<\/a>\u00a0Es la sustancia clave para la piroptosis despu\u00e9s de una lesi\u00f3n. Cuando se lesiona, el cuerpo puede activar la se\u00f1al de patr\u00f3n relacionada con los patrones moleculares asociados a pat\u00f3genos (PAMP) y los patrones moleculares asociados a da\u00f1os (DAMP).\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib48\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib48\"><span class=\"anchor-text\">[48]<\/span><\/a>. Cuando se produce la estimulaci\u00f3n de la se\u00f1al, el intracelular\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la prote\u00edna promotora en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/promoter-protein\">prote\u00edna promotora<\/a>\u00a0receptor tipo dominio de oligomerizaci\u00f3n de uni\u00f3n a nucle\u00f3tidos\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el dominio pirina en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyrin-domain\">dominio pirina<\/a>\u00a0que contiene 3 (NLRP3) puede reclutar una gran cantidad de procaspasa-1 utilizando la mol\u00e9cula adaptadora del inflamasoma ASC mediante oligomerizaci\u00f3n\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib49\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib49\"><span class=\"anchor-text\">[49]<\/span><\/a>, la formaci\u00f3n de prote\u00ednas agregadas de inflamasomas. La procaspasa-1 es el precursor de la caspasa-1 y normalmente la procaspasa-1 existe en el cuerpo en forma de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el zim\u00f3geno en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/enzyme-precursor\">zim\u00f3geno<\/a>. Cuando se env\u00edan se\u00f1ales estimulantes a la procaspasa-1, genera subunidades P20 y P10 mediante autohidr\u00f3lisis. Esta subunidad forma primero una\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el heterod\u00edmero en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/heterodimer\">heterod\u00edmero<\/a>\u00a0que no puede funcionar y luego se agrega para formar una\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el tetr\u00e1mero en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tetramer\">tetr\u00e1mero<\/a>\u00a0que promueve la actividad de caspasa-1, lo que lleva a la activaci\u00f3n de caspasa-1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib50\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib50\"><span class=\"anchor-text\">[50]<\/span><\/a>. Cuando se activa la caspasa-1, la caspasa-1 activa es responsable de la formaci\u00f3n de poros de la membrana celular y de la r\u00e1pida lisis de la membrana celular para formar una respuesta inflamatoria. Mientras tanto, la caspasa-1 tambi\u00e9n puede inducir a los precursores de IL-1\u03b2 e IL-18, pro-IL-1\u03b2 y pro-IL-18, para acelerar el proceso de maduraci\u00f3n. La IL-1\u03b2 y la IL-18 maduras se liberan extracelularmente, reclutando as\u00ed m\u00e1s inflamasomas. Despu\u00e9s de que el inflamasoma se agrega, la respuesta inflamatoria se agrava a\u00fan m\u00e1s y el da\u00f1o tisular se agrava. Despu\u00e9s de que la IL-1\u03b2 se libera de las c\u00e9lulas, los factores inflamatorios se propagan a los tejidos adyacentes junto con el flujo de linfa, agravando a\u00fan m\u00e1s la respuesta inflamatoria. La secreci\u00f3n de una gran cantidad de IL-18 provoca respuestas inmunitarias Th1 y Th2 y estimula la respuesta inmunitaria para que desempe\u00f1e un papel.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib51\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib51\"><span class=\"anchor-text\">[51]<\/span><\/a>.<\/p>\n<section id=\"sec0025\">\n<h4 id=\"sect0045\" class=\"u-margin-m-top u-margin-xs-bottom\">2.2.1. V\u00eda de piroptosis can\u00f3nica<\/h4>\n<p id=\"p0045\">La caspasa-1 es una prote\u00edna clave en la v\u00eda piropt\u00f3tica can\u00f3nica, en la que el inflamasoma juega un papel importante en la activaci\u00f3n de la caspasa-1.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib52\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib52\"><span class=\"anchor-text\">[52]<\/span><\/a>. El inflamasoma es una parte importante del sistema inmunol\u00f3gico innato y es un complejo multiproteico compuesto por prote\u00ednas sensoras, ASC y pro-Caspasa-1. Existe en el citoplasma de estimulados.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las c\u00e9lulas inmunitarias en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunocompetent-cell\">c\u00e9lulas inmunes<\/a>\u00a0y puede detectar se\u00f1ales de estimulaci\u00f3n extracelular\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib53\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib53\"><span class=\"anchor-text\">[53]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib54\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib54\"><span class=\"anchor-text\">[54]<\/span><\/a>. Los inflamasomas se dividen en inflamasomas que contienen receptores similares a dominios de oligomerizaci\u00f3n (NLR) de uni\u00f3n a nucle\u00f3tidos, resumen en\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el melanoma en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nodular-melanoma\">melanoma<\/a>\u00a02 (AIM2) inflamasomas e inflamasomas NLRC4\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib55\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib55\"><span class=\"anchor-text\">[55]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib56\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib56\"><span class=\"anchor-text\">[56]<\/span><\/a>. El receptor purin\u00e9rgico 2 \u00d7 7 (P2X7) es un receptor de canal i\u00f3nico transmembrana activado por ATP expresado en\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la microgl\u00eda en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microglia\">microgl\u00eda<\/a>\u00a0y es un factor clave en la activaci\u00f3n del inflamasoma. Los estudios han demostrado que el ATP extracelular puede regular la salida de K+ activando el\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el receptor P2X7 en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/purinergic-p2x7-receptor\">receptor P2X7<\/a>, induciendo la activaci\u00f3n de la familia NLR, que contiene el dominio pirina 3 (NLRP3)\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib57\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib57\"><span class=\"anchor-text\">[57]<\/span><\/a>. El inflamasoma NLRP3 es el m\u00e1s estudiado actualmente. La activaci\u00f3n del inflamasoma NLRP3 requiere una respuesta de dos pasos: inicio de la respuesta, factor nuclear microbiano o end\u00f3geno-\u03baB (NF-\u03baB) en el n\u00facleo y regulaci\u00f3n positiva de la expresi\u00f3n de NLRP3 y pro-IL-1\u03b2.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib58\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib58\"><span class=\"anchor-text\">[58]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib59\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib59\"><span class=\"anchor-text\">[59]<\/span><\/a>. Cuando las c\u00e9lulas inmunes son estimuladas por DAMP, la prote\u00edna sensora recluta pro-Caspasa-1 a trav\u00e9s de la ASC, que luego se activa mediante autohidr\u00f3lisis. La caspasa-1 madura procesa pro-IL-1\u03b2 y pro-IL-18 inactivas aguas abajo en IL-1\u03b2 e IL-18 activas\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib60\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib60\"><span class=\"anchor-text\">[60]<\/span><\/a>. Mientras tanto, la caspasa-1 escinde la prote\u00edna GSDMD aguas abajo en un fragmento GSDMD-N y un fragmento GSDMD-C con actividad formadora de poros. El fragmento GSDMD-N reconoce y se une espec\u00edficamente al\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los l\u00edpidos de membrana en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/membrane-lipid\">l\u00edpidos de membrana<\/a>\u00a0en el lado interno de la membrana celular, provocando cambios en la presi\u00f3n osm\u00f3tica intracelular y extracelular, lo que a su vez conduce a la inflamaci\u00f3n y ruptura celular y a la liberaci\u00f3n de factores inflamatorios IL-1\u03b2 e IL-18, induciendo una respuesta inflamatoria y piroptosis celular.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib61\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib61\"><span class=\"anchor-text\">[61]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0030\">\n<h4 id=\"sect0050\" class=\"u-margin-m-top u-margin-xs-bottom\">2.2.2. V\u00eda de piroptosis no can\u00f3nica<\/h4>\n<p id=\"p0050\">La familia de caspasas se divide principalmente en dos categor\u00edas: relacionadas con la apoptosis y relacionadas con la inflamaci\u00f3n seg\u00fan diferentes funciones. Las caspasas-3\/2\/10 median principalmente la apoptosis, mientras que las caspasas-1\/4\/5\/11 son mediadoras clave de la inflamaci\u00f3n y las respuestas inmunes innatas.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib62\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib62\"><span class=\"anchor-text\">[62]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib63\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib63\"><span class=\"anchor-text\">[63]<\/span><\/a>. La v\u00eda piropt\u00f3tica no can\u00f3nica depende de la activaci\u00f3n de Caspasa-4\/5\/11, mientras que el inflamasoma no es esencial para la maduraci\u00f3n de IL-1\u03b2 e IL-18.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib64\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib64\"><span class=\"anchor-text\">[64]<\/span><\/a>. La v\u00eda no cl\u00e1sica de la piroptosis es inducida por\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los lipopolisac\u00e1ridos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/lipopolysaccharide\">lipopolisac\u00e1rido<\/a>\u00a0(LPS), un componente de la pared celular de las bacterias Gram negativas. El LPS puede unirse directamente a la Caspasa-4\/5 humana y a la Caspasa-11 de rat\u00f3n. Estas caspasas act\u00faan como prote\u00ednas sensoras y mol\u00e9culas efectoras de LPS. La Caspasa-4\/5\/11 activada escinde directamente GSDMD e induce piroptosis\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib65\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib65\"><span class=\"anchor-text\">[65]<\/span><\/a>. Adem\u00e1s, los estudios han encontrado que Caspasa-11 puede activar el sistema descendente\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la uni\u00f3n de brechas en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/gap-junction\">brecha de la salida<\/a>\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la prote\u00edna del canal en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/channel-protein\">prote\u00edna del canal<\/a>\u00a0Pannexin-1 para promover la salida de K+, y la salida de K+ puede activar el inflamasoma NLRP3, que a su vez activa la caspasa-1 y promueve la maduraci\u00f3n de IL-1\u03b2 e IL-18.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib66\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib66\"><span class=\"anchor-text\">[66]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0035\">\n<h4 id=\"sect0055\" class=\"u-margin-m-top u-margin-xs-bottom\">2.2.3. La relaci\u00f3n entre GSDMD y piroptosis.<\/h4>\n<p id=\"p0055\">GSDMD (Gsdermin D) es una prote\u00edna compuesta por 484 fragmentos de residuos de amino\u00e1cidos y es miembro de la familia de prote\u00ednas Gasdermin. Hay principalmente 5 miembros en esta familia, son: DFNA5, DFNB59, GSDMA, GSDMB, GSDMCD. Las estructuras de amino\u00e1cidos de estas cinco prote\u00ednas son muy similares y estas prote\u00ednas contienen dos dominios espaciales, N-terminal y C-terminal.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib67\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib67\"><span class=\"anchor-text\">[67]<\/span><\/a>. La prote\u00edna GSDMD es un amino de cadena larga\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la prote\u00edna \u00e1cida en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/acid-protein\">prote\u00edna \u00e1cida<\/a>, y la estructura entre sus dominios N-terminal y C-terminal es relativamente flexible. GSDMD normalmente se escinde en\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la secuencia de amino\u00e1cidos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/peptide-sequence\">secuencia de amino\u00e1cidos<\/a>\u00a0275, exponiendo los dominios N-terminal y C-terminal. En\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las c\u00e9lulas de mam\u00edferos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mammalian-cell\">c\u00e9lulas mam\u00edferas<\/a>, la estructura N-terminal simple de GSDMD puede regular la piroptosis celular. Por lo tanto, GSDMD a menudo expresa el dominio N-terminal pero no puede expresar todas las prote\u00ednas GSDMD.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib68\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib68\"><span class=\"anchor-text\">[68]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib69\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib69\"><span class=\"anchor-text\">[69]<\/span><\/a>. Sin embargo, los estudios han demostrado que cuando el dominio N-terminal de GSDMD se introdujo en E. coli para su cultivo, se produjeron fuertes efectos t\u00f3xicos. Por el contrario, GSDMD intacto y el dominio C-terminal de GSDMD mostraron una toxicidad relativamente baja.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib70\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib70\"><span class=\"anchor-text\">[70]<\/span><\/a>. La estructura N-terminal del GSDMD intracelular se transferir\u00e1 gradualmente a la membrana celular con la invasi\u00f3n de factores de da\u00f1o y a la membrana celular, donde se une espec\u00edficamente a la fosfosarcosinasa y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la fosfatidilserina en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/phosphatidylserine\">fosfatidilserina<\/a>\u00a0en la membrana celular para producir efectos biol\u00f3gicos\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib71\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib71\"><span class=\"anchor-text\">[71]<\/span><\/a>. Usar equipos como la fuerza at\u00f3mica.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la microscop\u00eda electr\u00f3nica en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/electron-microscopy\">microscopio de electrones<\/a>\u00a0y microscop\u00eda crioelectr\u00f3nica, L. Sborigi observ\u00f3 que la estructura N-terminal de GSDMD se puede combinar con biopel\u00edculas para formar un pol\u00edmero hueco en forma de anillo en la biopel\u00edcula. Este pol\u00edmero induce la formaci\u00f3n de poros de biopel\u00edcula, por lo que GSDMD induce piroptosis en las c\u00e9lulas cuando se produce da\u00f1o end\u00f3geno. cuando externo\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los pat\u00f3genos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathogen\">pat\u00f3genos<\/a>\u00a0Invaden, son capaces de adsorberse en la superficie celular de pat\u00f3genos y proteger al cuerpo de sustancias nocivas externas lisando las c\u00e9lulas.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib72\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib72\"><span class=\"anchor-text\">[72]<\/span><\/a>. GSDMD es una sustancia que se une espec\u00edficamente a las prote\u00ednas caspasa-1\/4\/5\/11 aguas abajo de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la transducci\u00f3n de se\u00f1ales en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/signal-transduction\">transducci\u00f3n de se\u00f1ales<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib73\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib73\"><span class=\"anchor-text\">[73]<\/span><\/a>. La caspasa-1 promueve la liberaci\u00f3n de IL-1\u03b2 e IL-18 aguas abajo fuera de la membrana celular a trav\u00e9s de respuestas inflamas\u00f3micas generadas por complejos con varias prote\u00ednas. La caspasa-1 activada escinde la prote\u00edna GSDMD y convierte GSDMD en p\u00e9ptidos activos. Los productos de descomposici\u00f3n de GSDMD se unen espec\u00edficamente a la membrana celular y componentes como las mol\u00e9culas de agua extracelular ingresan a la membrana celular a trav\u00e9s de los poros, lo que hace que las c\u00e9lulas se hinchen y eventualmente se rompan.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib74\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib74\"><span class=\"anchor-text\">[74]<\/span><\/a>.<\/p>\n<\/section>\n<\/section>\n<section id=\"sec0040\">\n<h3 id=\"sect0060\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.3. Los ARN no codificantes participan en la expresi\u00f3n de genes piropt\u00f3ticos en IS<\/h3>\n<p id=\"p0060\">En los \u00faltimos a\u00f1os tambi\u00e9n se ha desarrollado plenamente el mecanismo regulador a nivel gen\u00e9tico relacionado con la aparici\u00f3n de piroptosis. Los estudios de biolog\u00eda molecular modernos muestran que el 98% del genoma no participa en la codificaci\u00f3n de prote\u00ednas. Los ARN codificantes de cadena larga (lncRNA) son ARN sin funci\u00f3n codificadora de prote\u00ednas, llamados as\u00ed porque tienen m\u00e1s de 200 nucle\u00f3tidos de longitud.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib75\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib75\"><span class=\"anchor-text\">[75]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib76\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib76\"><span class=\"anchor-text\">[76]<\/span><\/a>. Sin embargo aunque\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre lncRNA en las p\u00e1ginas de temas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/long-untranslated-rna\">ARNnc<\/a>\u00a0no tiene la funci\u00f3n de codificar prote\u00ednas, es el gen m\u00e1s expresado en el organismo y el gen m\u00e1s conservado en la transcripci\u00f3n. Participa en importantes procesos patol\u00f3gicos y fisiol\u00f3gicos del organismo, especialmente en enfermedades relacionadas con lesiones por reperfusi\u00f3n, y juega un papel importante.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib77\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib77\"><span class=\"anchor-text\">[77]<\/span><\/a>. Los estudios han demostrado que en la microgl\u00eda, el nivel de expresi\u00f3n de lncRNA-H19 se correlaciona positivamente con la duraci\u00f3n de la reperfusi\u00f3n.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib78\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib78\"><span class=\"anchor-text\">[78]<\/span><\/a>. La sobreexpresi\u00f3n de LncRNA-H19 desempe\u00f1a un papel inflamatorio cuando promueve la expresi\u00f3n de la mol\u00e9cula de se\u00f1alizaci\u00f3n NLRP3\/6 e inicia GSDMD\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib79\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib79\"><span class=\"anchor-text\">[79]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib80\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib80\"><span class=\"anchor-text\">[80]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib81\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib81\"><span class=\"anchor-text\">[81]<\/span><\/a>. lncRNA-H19 es capaz de activar miembros de la familia de prote\u00ednas caspasas\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib82\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib82\"><span class=\"anchor-text\">[82]<\/span><\/a>, provocando disfunci\u00f3n mitocondrial, participando en la activaci\u00f3n de inflamasomas y provocando da\u00f1o neuronal\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib83\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib83\"><span class=\"anchor-text\">[83]<\/span><\/a>. Adem\u00e1s de la regulaci\u00f3n de la estructura molecular, el lncRNA-H19 tambi\u00e9n puede reclutar m\u00e1s factores de transcripci\u00f3n para regular el proceso de transcripci\u00f3n del ARNm.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib84\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib84\"><span class=\"anchor-text\">[84]<\/span><\/a>. Adem\u00e1s, lncRNA-H19 tambi\u00e9n puede promover la\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el transporte nuclear en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nucleocytoplasmic-transport\">transporte nuclear<\/a>\u00a0proceso de factores de transcripci\u00f3n, aumentando as\u00ed la expresi\u00f3n espec\u00edfica de m\u00e1s genes diana y generando una red de cascada inflamatoria cuando\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la isquemia en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemia\">isquemia<\/a>\u00a0ocurre\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib84\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib84\"><span class=\"anchor-text\">[84]<\/span><\/a>. Por lo tanto, lncRNA-H19 es una fuerte se\u00f1al de peligro cuando\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre CIRI en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunoreactive-insulin\">CIRI<\/a>\u00a0ocurre, y la inhibici\u00f3n de H19 puede ser un potencial\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el tratamiento en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/therapeutic-procedure\">tratamiento<\/a>\u00a0para lesi\u00f3n por isquemia-reperfusi\u00f3n\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib84\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib84\"><span class=\"anchor-text\">[84]<\/span><\/a>. En la piroptosis mediada por inflamasoma AIM2 capaz de causar lesi\u00f3n por isquemia-reperfusi\u00f3n, el eje lincRNA MEG3\/miR-485\/AIM2 promueve la piroptosis activando la se\u00f1alizaci\u00f3n de caspasa1 durante CIRI y, por lo tanto, este eje puede ser un objetivo terap\u00e9utico eficaz para\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre IS en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/brain-ischemia\">ES<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib84\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib84\"><span class=\"anchor-text\">[84]<\/span><\/a>. Para el\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la regulaci\u00f3n inmune en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunoregulation\">regulaci\u00f3n inmune<\/a>\u00a0de microgl\u00eda, Wang et al. descubri\u00f3 que LncRNA-Fendrr protege el\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la ubiquitinaci\u00f3n en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ubiquitination\">ubiquitinaci\u00f3n<\/a>\u00a0y degradaci\u00f3n de la prote\u00edna NLRC4 a trav\u00e9s de HERC2 y regula la piroptosis microglial\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib85\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib85\"><span class=\"anchor-text\">[85]<\/span><\/a>. Zhang et al. encontr\u00f3 que el eje lncRNA NEAT1 \/ miR-22-3p inhibi\u00f3 la piroptosis y atenu\u00f3 la lesi\u00f3n CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib86\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib86\"><span class=\"anchor-text\">[86]<\/span><\/a>. Los experimentos de lesi\u00f3n por privaci\u00f3n de ox\u00edgeno-glucosa (OGD) in vitro despu\u00e9s de IS mostraron que la OGD aumentaba la expresi\u00f3n de la prote\u00edna 3 del receptor tipo NOD (NLRP3) para inducir la muerte piropt\u00f3tica de las NSC, que fue rescatada por\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la oxigenoterapia hiperb\u00e1rica en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hyperbaric-medicine\">oxigenoterapia hiperb\u00e1rica<\/a>. El lncRNA-H19 regulado positivamente act\u00faa como una esponja molecular para miR-423\u20135p, dirigi\u00e9ndose a NLRP3 despu\u00e9s de OGD para inducir la piroptosis de c\u00e9lulas madre neurales (NSC). Por lo tanto, se confirm\u00f3 que la terapia con ox\u00edgeno hiperb\u00e1rico protege a las NSC de la piroptosis al inhibir el eje lncRNA-H19\/miR-423\u20135p\/NLRP3.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib87\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib87\"><span class=\"anchor-text\">[87]<\/span><\/a>. miR-21 es un\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el microARN en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microrna\">microARN<\/a>\u00a0(miARN) que est\u00e1 estrechamente relacionado con la aparici\u00f3n de piroptosis. Los estudios han demostrado que miR-21 puede regular espec\u00edficamente la prote\u00edna NLRP3, activar la prote\u00edna NLRP3, estimular la secreci\u00f3n de NLRP3 y expresarse en macr\u00f3fagos a trav\u00e9s de la se\u00f1alizaci\u00f3n de NF-\u03baB a trav\u00e9s de la v\u00eda de retroalimentaci\u00f3n inflamatoria.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib88\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib88\"><span class=\"anchor-text\">[88]<\/span><\/a>. Adem\u00e1s de activar NLRP3, miR-21 tambi\u00e9n puede regular la activaci\u00f3n de caspasa-1 aguas abajo, promover la secreci\u00f3n de IL-1\u03b2 y promover la aparici\u00f3n de piroptosis. Cuando miR-21 es deficiente, la expresi\u00f3n de la v\u00eda caspasa-1 regulada por NLRP3 se reduce significativamente. Por lo tanto, el nivel de expresi\u00f3n de miR-21 tambi\u00e9n es un v\u00ednculo clave en la regulaci\u00f3n de la aparici\u00f3n de piroptosis.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib89\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib89\"><span class=\"anchor-text\">[89]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib90\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib90\"><span class=\"anchor-text\">[90]<\/span><\/a>. Los estudios de biolog\u00eda molecular modernos han demostrado que miR-214\u20133p tiene un sitio de uni\u00f3n para caspasa-1, que puede unirse espec\u00edficamente a la aparici\u00f3n de caspasa-1, regulando as\u00ed la respuesta inflamatoria y aumentando la incidencia de piroptosis.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib91\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib91\"><span class=\"anchor-text\">[91]<\/span><\/a>.<\/p>\n<div>\n<p id=\"p0065\">El mecanismo molecular de la piroptosis se resumi\u00f3 en\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#fig0005\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"fig0005\"><span class=\"anchor-text\">Figura 1<\/span><\/a>.<\/p>\n<figure id=\"fig0005\" class=\"figure text-xs\"><img decoding=\"async\" src=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr1.jpg\" alt=\"Fig. 1\" height=\"414\" aria-describedby=\"cap0005\" \/><\/p>\n<ol class=\"u-margin-s-bottom\">\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"Descargar imagen de alta resoluci\u00f3n (294KB)\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr1_lrg.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">Descargar :\u00a0<span class=\"download-link-title\">Descargar imagen de alta resoluci\u00f3n (294KB)<\/span><\/span><\/a><\/li>\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"Descargar imagen en tama\u00f1o completo\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr1.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">Descargar :\u00a0<span class=\"download-link-title\">Descargar imagen en tama\u00f1o completo<\/span><\/span><\/a><\/li>\n<\/ol>\n<p id=\"sp0005\"><span class=\"label\">Figura 1<\/span>. El mecanismo molecular de la piroptosis (los mecanismos de la piroptosis incluyen la v\u00eda del inflamasoma can\u00f3nico y la v\u00eda del inflamasoma no can\u00f3nico. La v\u00eda del inflamasoma can\u00f3nica se desencadena por DAMP o PAMP. La v\u00eda del inflamasoma no can\u00f3nica se desencadena por LPS de bacterias gramnegativas extracelulares o estimulaci\u00f3n de la muerte. Despu\u00e9s de la activaci\u00f3n, la piroptosis se desencadena a trav\u00e9s de una serie de interacciones intermoleculares.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre TLR en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/toll-like-receptor\">TLR<\/a>: Receptor tipo peaje; GSDM: Gsdermin; NLRP3: receptor tipo dominio de oligomerizaci\u00f3n de uni\u00f3n a nucle\u00f3tidos\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el dominio pirina en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyrin-domain\">dominio pirina<\/a>\u00a0que contiene 3; HUMEDAD: patr\u00f3n molecular asociado al da\u00f1o; PAMP: patr\u00f3n molecular asociado a pat\u00f3genos).<\/p>\n<\/figure>\n<\/div>\n<\/section>\n<section id=\"sec0045\">\n<h3 id=\"sect0065\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.4. La relaci\u00f3n entre piroptosis y otros da\u00f1os celulares.<\/h3>\n<p id=\"p0070\">Hay muchos mecanismos implicados en la aparici\u00f3n de lesi\u00f3n por isquemia-reperfusi\u00f3n cerebral. Los mecanismos conocidos est\u00e1n relacionados con diversos mecanismos, como la respuesta inflamatoria, el trastorno de los canales de calcio, el deterioro de la funci\u00f3n mitocondrial y la autofagia. La piroptosis est\u00e1 implicada en todos los aspectos de la lesi\u00f3n por isquemia-reperfusi\u00f3n cerebral y est\u00e1 estrechamente relacionada con otras lesiones.<\/p>\n<p id=\"p0075\">La aparici\u00f3n de piroptosis y apoptosis pertenecen a una forma de muerte celular, pero son fundamentalmente diferentes. La apoptosis es una forma fisiol\u00f3gica de muerte celular, mientras que la piroptosis a menudo se asocia con la muerte celular patol\u00f3gica despu\u00e9s de una lesi\u00f3n corporal.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib92\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib92\"><span class=\"anchor-text\">[92]<\/span><\/a>. La autofagia es un tipo de fen\u00f3meno de autofagia que existe ampliamente en\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las c\u00e9lulas eucariotas en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/eukaryotic-cell\">c\u00e9lulas eucariotas<\/a>. La autofagia generalmente se divide en tres tipos: autofagia mediada por chaperonas, microautofagia y macroautofagia. En la actualidad existen numerosos estudios sobre macroautofagia.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib93\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib93\"><span class=\"anchor-text\">[93]<\/span><\/a>. La autofagia es una parte indispensable del proceso metab\u00f3lico normal de las c\u00e9lulas. La inhibici\u00f3n de la autofagia puede provocar la acumulaci\u00f3n de sustancias nocivas en tejidos, \u00f3rganos o c\u00e9lulas. La activaci\u00f3n excesiva de la autofagia destruir\u00e1 importantes org\u00e1nulos intracelulares y prote\u00ednas esenciales, lo que desencadenar\u00e1 la apoptosis autof\u00e1gica.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib94\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib94\"><span class=\"anchor-text\">[94]<\/span><\/a>.<\/p>\n<p id=\"p0080\">La piroptosis y la autofagia est\u00e1n indisolublemente ligadas. En circunstancias normales, la aparici\u00f3n de autofagia y piroptosis in vivo se produce en un estado de equilibrio din\u00e1mico. Cuando el cuerpo genera una respuesta inflamatoria a est\u00edmulos externos, el equilibrio entre la autofagia y la piroptosis se altera.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib95\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib95\"><span class=\"anchor-text\">[95]<\/span><\/a>. Por ejemplo, NF-\u03baB es un\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la v\u00eda de transducci\u00f3n de se\u00f1ales en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/signal-transduction-pathway\">v\u00eda de transducci\u00f3n de se\u00f1ales<\/a>\u00a0que participa en la transducci\u00f3n de se\u00f1ales de muchos\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las v\u00edas de se\u00f1ales en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-signaling-pathway\">v\u00edas de se\u00f1al<\/a>\u00a0para lograr la transducci\u00f3n de se\u00f1ales. El estudio encontr\u00f3 que en ratones IS con desactivaci\u00f3n del gen NF-\u03baB,\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre mTOR en las p\u00e1ginas de temas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mammalian-target-of-rapamycin\">mTOR<\/a>\u00a0se inhibi\u00f3 la actividad y se mejoraron los niveles de autofagia. La v\u00eda de activaci\u00f3n de se\u00f1alizaci\u00f3n de NF-\u03baB es una gran cantidad de est\u00edmulos para activar las quinasas inducidas por NF-\u03baB, que activan los tr\u00edmeros I\u03baK\u03b1, I\u03baKB e I\u03baK\u03b3, lo que resulta en la fosforilaci\u00f3n y degradaci\u00f3n de I\u03baB, y finalmente activan la v\u00eda de se\u00f1alizaci\u00f3n de NF-\u03baB. . Despu\u00e9s de la activaci\u00f3n, NF-\u03baB ingresa a la c\u00e9lula y se une espec\u00edficamente a su correspondiente receptor de ADN, estimulando as\u00ed la transcripci\u00f3n de factores inflamatorios y promoviendo la expresi\u00f3n masiva de los factores inflamatorios TNF-\u03b1, IL-1\u03b2 e IL-6. Los estudios han demostrado que la v\u00eda de se\u00f1alizaci\u00f3n NF-\u03baB participa en la regulaci\u00f3n de la activaci\u00f3n de los niveles pre y postranscripcionales de la prote\u00edna piropt\u00f3tica clave NLRP3 para inducir la piroptosis. Los factores inflamatorios abundantemente expresados pueden inducir una cascada inflamatoria en el cuerpo, inducir piroptosis y expandir a\u00fan m\u00e1s la respuesta inflamatoria, agravando as\u00ed el da\u00f1o cerebral.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib96\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib96\"><span class=\"anchor-text\">[96]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib97\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib97\"><span class=\"anchor-text\">[97]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib98\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib98\"><span class=\"anchor-text\">[98]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0050\">\n<h3 id=\"sect0070\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.5. Mecanismos de piroptosis e inflamaci\u00f3n implicados en el IS.<\/h3>\n<p id=\"p0085\">Existen cascadas inflamatorias en varias etapas del IS\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib99\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib99\"><span class=\"anchor-text\">[99]<\/span><\/a>. En las primeras etapas del IS, el flujo sangu\u00edneo en el cerebro se ralentiza y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los neutr\u00f3filos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neutrophil\">neutr\u00f3filos<\/a>\u00a0adherirse a la\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las c\u00e9lulas endoteliales en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/endothelial-cell\">c\u00e9lulas endoteliales<\/a>\u00a0de los vasos isqu\u00e9micos y comienza una respuesta inflamatoria aguda inicial.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib100\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib100\"><span class=\"anchor-text\">[100]<\/span><\/a>. Cuando ocurre la reperfusi\u00f3n despu\u00e9s de la isquemia cerebral, los factores inflamatorios ex\u00f3genos, las c\u00e9lulas inflamatorias y los factores inflamatorios atraviesan la barrera hematoencef\u00e1lica, lo que resulta en el efecto secundario de la isquemia despu\u00e9s de la reperfusi\u00f3n y conduce a la liberaci\u00f3n de una gran cantidad de factores de oxidaci\u00f3n y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los radicales libres en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/radical-chemistry\">radicales libres<\/a>. En este momento, la microglia en el\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el tejido cerebral en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-tissue\">tejido cerebral<\/a>\u00a0se activan gradualmente en grandes cantidades y producen m\u00e1s\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los mediadores inflamatorios en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammatory-mediator\">mediadores inflamatorios<\/a>. Este tipo de mediadores inflamatorios pueden sobreactivar las c\u00e9lulas endoteliales del tejido cerebral y producir una gran cantidad de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el factor tisular en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/thromboplastin\">factor tisular<\/a>\u00a0acumular la toxicidad de los amino\u00e1cidos. Esto agrava a\u00fan m\u00e1s la liberaci\u00f3n de factores oxidativos, radicales libres y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el mon\u00f3xido de carbono en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/carbon-monoxide\">mon\u00f3xido de carbono<\/a>y activa v\u00edas de se\u00f1alizaci\u00f3n relacionadas con la respuesta inflamatoria, como NF-\u03baB, receptores tipo Toll y receptores tipo Nod (NLR)\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib101\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib101\"><span class=\"anchor-text\">[101]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib102\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib102\"><span class=\"anchor-text\">[102]<\/span><\/a>. Por ejemplo, los NLR, los estudios han demostrado que hay 23 miembros de la familia de los NLR, que se expresan principalmente en el citoplasma celular y desempe\u00f1an un papel clave en la respuesta inmune innata del cuerpo. Los miembros de la familia NLR, Nalp1, Nalp3, Nalp5 e Ipaf, son capaces de activar la activaci\u00f3n de caspasa-1 a trav\u00e9s de la\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la prote\u00edna adaptadora en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/adaptor-protein\">prote\u00edna adaptadora<\/a>\u00a0ASC, inicia una cascada de respuestas inflamatorias y media la piroptosis.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib103\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib103\"><span class=\"anchor-text\">[103]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib104\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib104\"><span class=\"anchor-text\">[104]<\/span><\/a>. NLRP3 es un componente importante de los factores inflamatorios. NLRP3 contiene tres dominios: PYD, NACHT y LRR, que pueden representarse mediante LRR-NACHT-PYD: PYD-CARD: CARD-CARDC un dominio espase. Responde a diversas se\u00f1ales de da\u00f1o end\u00f3geno, por lo que la activaci\u00f3n del inflamasoma NLRP3 se considera el principal tipo de piroptosis.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib105\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib105\"><span class=\"anchor-text\">[105]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib106\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib106\"><span class=\"anchor-text\">[106]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib107\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib107\"><span class=\"anchor-text\">[107]<\/span><\/a>.<\/p>\n<p id=\"p0090\">Los inflamasomas son complejos proteicos que se ensamblan despu\u00e9s de que el cuerpo recibe se\u00f1ales de infecci\u00f3n o da\u00f1o celular y sirven como plataforma para el reclutamiento y activaci\u00f3n de la procaspasa-1. La prote\u00edna promotora NLRP3 puede reclutar grandes cantidades de procaspasa-1 mediante oligomerizaci\u00f3n utilizando la mol\u00e9cula adaptadora del inflamasoma ASC.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib108\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib108\"><span class=\"anchor-text\">[108]<\/span><\/a>. La procaspasa-1 es la precursora de la caspasa-1, y la caspasa-1 activa es responsable de lisar r\u00e1pidamente las c\u00e9lulas para activar y liberar IL-1\u03b2 e IL-18 extracelulares, lo que agrava a\u00fan m\u00e1s la respuesta inflamatoria. Por tanto, la aparici\u00f3n de piroptosis est\u00e1 estrechamente relacionada con la aparici\u00f3n de respuesta inflamatoria y la formaci\u00f3n de inflamasomas. La aparici\u00f3n de lesi\u00f3n cerebral por isquemia-reperfusi\u00f3n est\u00e1 m\u00e1s estrechamente relacionada con la interacci\u00f3n entre piroptosis y respuesta inflamatoria.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib109\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib109\"><span class=\"anchor-text\">[109]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib110\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib110\"><span class=\"anchor-text\">[110]<\/span><\/a>. Especialmente en el sistema nervioso central, los astrocitos inducen la activaci\u00f3n y proliferaci\u00f3n de la microgl\u00eda y producen una gran cantidad de mediadores inflamatorios. Estos mediadores inflamatorios pueden activar las c\u00e9lulas endoteliales para producir una variedad de factores tisulares, aumentar la toxicidad de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los amino\u00e1cidos excitadores en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/excitatory-amino-acid\">amino\u00e1cidos excitadores<\/a>y promover la liberaci\u00f3n de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el \u00f3xido n\u00edtrico en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nitric-oxide\">\u00f3xido n\u00edtrico<\/a>\u00a0y radicales libres de ox\u00edgeno. Las sustancias anteriores conducen adem\u00e1s a la activaci\u00f3n de m\u00faltiples v\u00edas de transducci\u00f3n de se\u00f1ales inflamatorias, como NF-\u03baB y JNK2\/STAT3, y promueven el ensamblaje de inflamasomas como NLRP1 y NLRP3. La caspasa-1 activada induce piroptosis de las c\u00e9lulas, expande la respuesta inflamatoria y agrava la lesi\u00f3n por isquemia-reperfusi\u00f3n cerebral\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib111\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib111\"><span class=\"anchor-text\">[111]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib112\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib112\"><span class=\"anchor-text\">[112]<\/span><\/a>. Algunos estudios han encontrado que, en comparaci\u00f3n con los ratones de tipo salvaje, los niveles de AIM2 e IL-1\u03b2 en el cerebro de AIM2\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los ratones knockout en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/knockout-mouse\">ratones knockout<\/a>\u00a0despu\u00e9s de la isquemia-reperfusi\u00f3n cerebral disminuyeron significativamente, el volumen del infarto se redujo significativamente y el\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la funci\u00f3n neurol\u00f3gica en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nervous-system-physiology\">funci\u00f3n neurol\u00f3gica<\/a>\u00a0Las puntuaciones tambi\u00e9n mejoraron significativamente. La inhibici\u00f3n de la activaci\u00f3n del inflamasoma AIM2 puede inhibir la aparici\u00f3n de piroptosis hasta cierto punto, reduciendo as\u00ed la lesi\u00f3n cerebral isqu\u00e9mica\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib113\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib113\"><span class=\"anchor-text\">[113]<\/span><\/a>. Por tanto, la piroptosis juega un papel importante en el proceso de lesi\u00f3n por isquemia-reperfusi\u00f3n cerebral. El inflamasoma NLRP3 es una prote\u00edna clave en la v\u00eda piropt\u00f3tica, y la inhibici\u00f3n de su expresi\u00f3n puede inhibir simult\u00e1neamente la expresi\u00f3n de prote\u00ednas relacionadas con la v\u00eda piropt\u00f3tica, limitar la respuesta inflamatoria y aliviar la lesi\u00f3n por isquemia-reperfusi\u00f3n cerebral.<\/p>\n<\/section>\n<section id=\"sec0055\">\n<h3 id=\"sect0075\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.6. La piroptosis y el da\u00f1o mitocondrial median la lesi\u00f3n por estr\u00e9s oxidativo despu\u00e9s de IS<\/h3>\n<p id=\"p0095\">Las mitocondrias participan principalmente en la respiraci\u00f3n aer\u00f3bica de las c\u00e9lulas y son el lugar donde se produce la respiraci\u00f3n aer\u00f3bica. Las mitocondrias proporcionan una base ionizada para la transmisi\u00f3n normal de se\u00f1ales entre las c\u00e9lulas y la transducci\u00f3n de se\u00f1ales de las c\u00e9lulas nerviosas.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib114\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib114\"><span class=\"anchor-text\">[114]<\/span><\/a>. El da\u00f1o mitocondrial es causado principalmente por anormalidades.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el metabolismo mitocondrial en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitochondrial-respiration\">metabolismo mitocondrial<\/a>\u00a0y da\u00f1o oxidativo\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib115\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib115\"><span class=\"anchor-text\">[115]<\/span><\/a>. Los estudios han demostrado que la lesi\u00f3n cerebral por isquemia-reperfusi\u00f3n est\u00e1 estrechamente relacionada con la disfunci\u00f3n mitocondrial\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib116\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib116\"><span class=\"anchor-text\">[116]<\/span><\/a>. El estr\u00e9s oxidativo, como clave de la aparici\u00f3n del da\u00f1o oxidativo, est\u00e1 estrechamente relacionado con la piroptosis\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib117\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib117\"><span class=\"anchor-text\">[117]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib118\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib118\"><span class=\"anchor-text\">[118]<\/span><\/a>. Es m\u00e1s probable que el estr\u00e9s oxidativo se exprese en la lesi\u00f3n del tejido cerebral, especialmente en la isquemia cerebral y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la lesi\u00f3n por reperfusi\u00f3n en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/reperfusion-injury\">lesi\u00f3n por reperfusi\u00f3n<\/a>\u00a0despu\u00e9s de la isquemia cerebral\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib119\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib119\"><span class=\"anchor-text\">[119]<\/span><\/a>. Cuando el cuerpo es atacado por sustancias nocivas externas, las c\u00e9lulas pueden secretar una gran cantidad de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre ROS en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/reactive-oxygen-species\">rosa<\/a>\u00a0y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el carb\u00f3n activado en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/activated-charcoal\">Carb\u00f3n activado<\/a>, que altera el equilibrio entre oxidaci\u00f3n y antioxidaci\u00f3n, lo que resulta en una serie de reacciones de da\u00f1o oxidativo.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib120\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib120\"><span class=\"anchor-text\">[120]<\/span><\/a>. La mayor\u00eda de las ROS son secretadas por las mitocondrias.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib121\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib121\"><span class=\"anchor-text\">[121]<\/span><\/a>. Cuando es estimulado por est\u00edmulos externos o se produce da\u00f1o end\u00f3geno, el cuerpo estimula la uni\u00f3n de nucle\u00f3tidos a NLRP3 induciendo altos niveles de ROS, activando el complejo proteico inflamasoma. Cuando las ROS se sobreactivan, el orden normal de las v\u00edas de se\u00f1alizaci\u00f3n en el cuerpo se altera, lo que resulta en la destrucci\u00f3n del material gen\u00e9tico, las prote\u00ednas y varios org\u00e1nulos (incluidas las mitocondrias) en las c\u00e9lulas. Cuando se da\u00f1an varios org\u00e1nulos de las c\u00e9lulas, como las mitocondrias, las c\u00e9lulas tienen una nutrici\u00f3n y un metabolismo anormales, y las ROS pueden agravar a\u00fan m\u00e1s el da\u00f1o de las c\u00e9lulas.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el endotelio vascular en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascular-endothelium\">endotelio vascular<\/a>\u00a0e inducir la perturbaci\u00f3n de la\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la microcirculaci\u00f3n en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microcirculation\">microcirculaci\u00f3n<\/a>\u00a0en el cerebro. El trastorno de permeabilidad de la barrera hematoencef\u00e1lica en el cerebro induce la sobreexpresi\u00f3n de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las mol\u00e9culas de adhesi\u00f3n celular en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-adhesion-molecule\">mol\u00e9culas de adhesi\u00f3n celular<\/a>, agravando as\u00ed la lesi\u00f3n cerebral\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib122\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib122\"><span class=\"anchor-text\">[122]<\/span><\/a>. Mientras tanto,\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el estr\u00e9s oxidativo en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/oxidative-stress\">estr\u00e9s oxidativo<\/a>\u00a0hace que las c\u00e9lulas exhiban gradualmente un modo de muerte celular caracterizado por un aumento\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la permeabilidad de la membrana celular en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-membrane-permeability\">permeabilidad de la membrana celular<\/a>\u00a0y la liberaci\u00f3n del contenido celular \u2013 piroptosis\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib120\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib120\"><span class=\"anchor-text\">[120]<\/span><\/a>. Por tanto, tanto la piroptosis como el da\u00f1o mitocondrial est\u00e1n implicados en el proceso patol\u00f3gico de la lesi\u00f3n por isquemia-reperfusi\u00f3n cerebral. Se ha informado que la prote\u00edna Drp1 relacionada con la motilidad mitocondrial es una prote\u00edna clave necesaria para que las mitocondrias mantengan funciones fisiol\u00f3gicas normales.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib123\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib123\"><span class=\"anchor-text\">[123]<\/span><\/a>. Cuando aumenta la expresi\u00f3n de Drp1, puede inhibir la\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la fisi\u00f3n mitocondrial en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitochondrial-fission\">fisi\u00f3n mitocondrial<\/a>\u00a0procesar y reducir el nivel de piroptosis, desacelerando as\u00ed la aparici\u00f3n de da\u00f1os\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib124\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib124\"><span class=\"anchor-text\">[124]<\/span><\/a>. Cuando el cuerpo recibe una variedad de est\u00edmulos de da\u00f1o end\u00f3genos y ex\u00f3genos, el proceso regulatorio de las v\u00edas de se\u00f1alizaci\u00f3n en el cuerpo cambia. Se manifiesta como una disminuci\u00f3n de la secreci\u00f3n de Drp1, da\u00f1o mitocondrial, disfunci\u00f3n mitocondrial y aumento de la apoptosis y piroptosis, lo que conduce a diversas enfermedades en el cuerpo.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib125\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib125\"><span class=\"anchor-text\">[125]<\/span><\/a>. Estudios recientes muestran que la disfunci\u00f3n mitocondrial induce la activaci\u00f3n del inflamasoma NLRP3 durante la lesi\u00f3n por isquemia\/reperfusi\u00f3n cerebral\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib126\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib126\"><span class=\"anchor-text\">[126]<\/span><\/a>. mitocondrial\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el desacoplamiento de la prote\u00edna 2 en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/uncoupling-protein-2\">prote\u00edna desacopladora 2<\/a>\u00a0(UCP2) exacerba la lesi\u00f3n cerebral despu\u00e9s de CIRI, y nuevos estudios muestran que la deficiencia de UCP2 mejora la activaci\u00f3n del inflamasoma NLRP3 despu\u00e9s de una exacerbaci\u00f3n de CIRI inducida por hiperglucemia in vitro e in vivo. UCP2 puede ser un objetivo terap\u00e9utico potencial para el empeoramiento de CIRI inducido por hiperglucemia. La deficiencia de UCP2 tambi\u00e9n mejor\u00f3 la activaci\u00f3n del inflamasoma NLRP3 y la producci\u00f3n de ROS en neuronas in vitro e in vivo\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib127\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib127\"><span class=\"anchor-text\">[127]<\/span><\/a>.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la adiponectina en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/adiponectin\">adiponectina<\/a>\u00a0es una hormona derivada del tejido adiposo con amplios efectos antioxidantes y antiinflamatorios. El p\u00e9ptido adiponectina aten\u00faa el estr\u00e9s oxidativo y la activaci\u00f3n del inflamasoma NLRP3 despu\u00e9s de una lesi\u00f3n por isquemia-reperfusi\u00f3n cerebral mediante la regulaci\u00f3n de AMPK\/GSK-3\u03b2\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib128\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib128\"><span class=\"anchor-text\">[128]<\/span><\/a>. Por lo tanto, en el IS, existe una estrecha relaci\u00f3n entre la aparici\u00f3n de piroptosis y el da\u00f1o mitocondrial, y existe una estrecha interacci\u00f3n entre ambos.<\/p>\n<\/section>\n<section id=\"sec0060\">\n<h3 id=\"sect0080\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.7. El estr\u00e9s oxidativo\/estr\u00e9s nitrosativo media la piroptosis despu\u00e9s de IS<\/h3>\n<p id=\"p0100\">Estr\u00e9s oxidativo\/nitrosativo y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la neuroinflamaci\u00f3n en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroinflammation\">neuroinflamaci\u00f3n<\/a>\u00a0son clave\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los procesos patol\u00f3gicos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathological-process\">procesos patol\u00f3gicos<\/a>\u00a0de la lesi\u00f3n cerebral por isquemia-reperfusi\u00f3n, que media el da\u00f1o neuronal, el da\u00f1o de la barrera hematoencef\u00e1lica y la transformaci\u00f3n hemorr\u00e1gica durante el accidente cerebrovascular isqu\u00e9mico\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib129\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib129\"><span class=\"anchor-text\">[129]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib130\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib130\"><span class=\"anchor-text\">[130]<\/span><\/a>. \u00d3xido n\u00edtrico (NO) y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el peroxinitrito en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/peroxynitrite\">peroxinitrito<\/a>\u00a0(ONOO-) son RNS t\u00edpicos en CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib130\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib130\"><span class=\"anchor-text\">[130]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib131\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib131\"><span class=\"anchor-text\">[131]<\/span><\/a>. Hay 3 is\u00f3meros de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la \u00f3xido n\u00edtrico sintasa en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nitric-oxide-synthase\">\u00f3xido n\u00edtrico sintasa<\/a>:\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la \u00f3xido n\u00edtrico sintasa endotelial en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/endothelial-nitric-oxide-synthase\">\u00f3xido n\u00edtrico sintasa endotelial<\/a>\u00a0(eNOS) produce una baja concentraci\u00f3n de NO y tiene funciones fisiol\u00f3gicas; mientras\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la \u00f3xido n\u00edtrico sintasa neuronal en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuronal-nitric-oxide-synthase\">\u00f3xido n\u00edtrico sintasa neuronal<\/a>\u00a0(nNOS) y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la \u00f3xido n\u00edtrico sintasa inducible en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inducible-nitric-oxide-synthase\">\u00f3xido n\u00edtrico sintasa inducible<\/a>\u00a0(iNOS) producen altas concentraciones de NO, lo que induce inflamaci\u00f3n y aumenta la permeabilidad de la barrera hematoencef\u00e1lica.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib132\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib132\"><span class=\"anchor-text\">[132]<\/span><\/a>. La sobreproducci\u00f3n de ROS\/RNS crea un microambiente estresante y conduce a una serie de cascadas de se\u00f1alizaci\u00f3n celular, que provocan inflamaci\u00f3n, hiperpermeabilidad de la barrera hematoencef\u00e1lica,\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el edema cerebral en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-edema\">edema cerebral<\/a>\u00a0y muerte de c\u00e9lulas neuronales\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib133\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib133\"><span class=\"anchor-text\">[133]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib134\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib134\"><span class=\"anchor-text\">[134]<\/span><\/a>. El peroxinitrito media\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la cadena de ADN en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/dna-strand\">Cadena de ADN<\/a>\u00a0rompe y activa el\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la ribozima en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ribozyme\">ribozima<\/a>\u00a0Poli(ADP-ribosa) sintasa (PARS), tambi\u00e9n conocida como poli(ADP-ribosa) polimerasa (PARP) o poli(ADPribosa)\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la transferasa en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/transferase\">transferasa<\/a>\u00a0(pADPRT). ONOO- puede activar directamente PARP\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib135\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib135\"><span class=\"anchor-text\">[135]<\/span><\/a>y experimentos in vivo e in vitro han demostrado el papel de la v\u00eda de se\u00f1alizaci\u00f3n ONOO-\/PARP en la lesi\u00f3n cerebral isqu\u00e9mica. Los experimentos in vivo mostraron que los ratones con deficiencia de NOS mostraban menos activaci\u00f3n de PARP en un modelo animal de accidente cerebrovascular isqu\u00e9mico. Los experimentos in vitro mostraron que los donantes de ONOO, pero no los donantes de NO, indujeron significativamente la activaci\u00f3n de PARP en C6 cultivado.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las c\u00e9lulas de glioma en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glioma-cell\">c\u00e9lulas de glioma<\/a>.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la disrupci\u00f3n gen\u00e9tica en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/gene-disruption\">Disrupci\u00f3n gen\u00e9tica<\/a>\u00a0o el silenciamiento de PARP reduce significativamente\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el tama\u00f1o del infarto cerebral en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-infarction-size\">tama\u00f1o del infarto cerebral<\/a>, alivia\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la neurotoxicidad en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neurotoxicity\">neurotoxicidad<\/a>, protege las unidades neurovasculares y mejora los resultados neurol\u00f3gicos\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib136\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib136\"><span class=\"anchor-text\">[136]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib137\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib137\"><span class=\"anchor-text\">[137]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib138\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib138\"><span class=\"anchor-text\">[138]<\/span><\/a>. Los estudios han encontrado que ROS\/RNS puede ser un activador del inflamasoma durante CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib139\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib139\"><span class=\"anchor-text\">[139]<\/span><\/a>. El inflamasoma es un complejo multiproteico en el citoplasma de la microgl\u00eda, de los cuales el receptor tipo NOD 3 (NLRP3) es el m\u00e1s estudiado. NLRP3 desencadena y activa la caspasa-1, activa IL-1\u03b2 e IL-18 y las libera en el\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el espacio extracelular en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/extracellular-space\">espacio extracelular<\/a>, promoviendo el desarrollo de la inflamaci\u00f3n.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib140\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib140\"><span class=\"anchor-text\">[140]<\/span><\/a>. Los experimentos in vivo mostraron que el tama\u00f1o del infarto cerebral y el da\u00f1o de la BBB en ratones knockout para NLPR3 eran menores que los de ratones de tipo salvaje. Experimentos adicionales demostraron que NLRP3 podr\u00eda mediar en la liberaci\u00f3n de IL-1\u03b2 y aumentar la permeabilidad de las c\u00e9lulas endoteliales microvasculares cerebrales.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib141\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib141\"><span class=\"anchor-text\">[141]<\/span><\/a>. Relacionado con el factor nuclear E2\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el factor 2 en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/prothrombin\">factor 2<\/a>\u00a0(Nrf2) regula las respuestas antioxidantes celulares y Nrf2 inhibe la producci\u00f3n de NLRP3 mediada por ROS en la microgl\u00eda BV2 en condiciones de privaci\u00f3n de ox\u00edgeno y glucosa.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib142\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib142\"><span class=\"anchor-text\">[142]<\/span><\/a>. Se descubri\u00f3 que el estr\u00e9s oxidativo\/nitrosativo induce la formaci\u00f3n de peroxinitrito, que puede ser un desencadenante clave de la activaci\u00f3n de caspasa1\/inflamasoma.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib143\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib143\"><span class=\"anchor-text\">[143]<\/span><\/a>. Por lo tanto, el inflamasoma mediado por ROS\/RNS puede ser un objetivo terap\u00e9utico potencial para la lesi\u00f3n cerebral isqu\u00e9mica.<\/p>\n<p id=\"p0105\">Adem\u00e1s, ROS\/RNS media la activaci\u00f3n de receptores tipo Toll. Los estudios actuales han demostrado que los receptores tipo Toll (TLR) se han estudiado ampliamente como un receptor innato.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el receptor inmunol\u00f3gico en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immune-system-receptors\">receptor inmunol\u00f3gico<\/a>, y TLR4\/2 se han estudiado m\u00e1s en cerebro\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la lesi\u00f3n isqu\u00e9mica en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemic-injury\">lesi\u00f3n isqu\u00e9mica<\/a>.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre TLR4 en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/toll-like-receptor-4\">TLR4<\/a>\u00a0puede mediar la expresi\u00f3n de IL-1\u03b2, MMP-9, iNOS y COX-2, y agravar el da\u00f1o cerebral inducido por el estr\u00e9s oxidativo\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib144\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib144\"><span class=\"anchor-text\">[144]<\/span><\/a>. La aplicaci\u00f3n del inhibidor TLR4.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre E5564 en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/eritoran\">E5564<\/a>\u00a0demostr\u00f3 que puede desempe\u00f1ar un\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre neuroprotectores en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroprotective-agent\">neuroprotector<\/a>\u00a0papel al inhibir la activaci\u00f3n de la microgl\u00eda y la producci\u00f3n de ROS\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib145\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib145\"><span class=\"anchor-text\">[145]<\/span><\/a>. Despu\u00e9s de IS, el tama\u00f1o del infarto de los ratones con deficiencia de TLR4 fue significativamente menor que el de los ratones de tipo salvaje\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib146\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib146\"><span class=\"anchor-text\">[146]<\/span><\/a>. TLR4 tambi\u00e9n participa en post-IS\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la neurog\u00e9nesis en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neurogenesis\">neurog\u00e9nesis<\/a>.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la tomograf\u00eda por emisi\u00f3n de positrones en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/positron-emission-tomography\">Tomograf\u00eda de emisi\u00f3n de positrones<\/a>\u00a0Los estudios han demostrado que los ratones con deficiencia de TLR4 han mejorado la neurog\u00e9nesis y han suprimido las respuestas inflamatorias en el IS.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib147\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib147\"><span class=\"anchor-text\">[147]<\/span><\/a>. Adem\u00e1s, estudios experimentales in vivo han demostrado que la inhibici\u00f3n de la v\u00eda de se\u00f1alizaci\u00f3n TLR2\/4\/NF-\u03baB tiene cierto efecto en la regulaci\u00f3n del estr\u00e9s oxidativo, la respuesta inflamatoria y la protecci\u00f3n del tejido cerebral isqu\u00e9mico.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib148\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib148\"><span class=\"anchor-text\">[148]<\/span><\/a>. Por tanto, TLR4\/2 puede ser un objetivo terap\u00e9utico para la lesi\u00f3n cerebral isqu\u00e9mica.<\/p>\n<\/section>\n<\/section>\n<section id=\"sec0065\">\n<h2 id=\"sect0085\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">3. La relaci\u00f3n entre piroptosis e IS<\/h2>\n<p id=\"p0110\">Los mecanismos patol\u00f3gicos del cerebro.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la isquemia en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemia\">isquemia<\/a>\u00a0y la lesi\u00f3n postisquemia-reperfusi\u00f3n son complejas. Los mecanismos implicados en este proceso incluyen inflamaci\u00f3n, estr\u00e9s oxidativo, autofagia, disfunci\u00f3n mitocondrial, sobrecarga de calcio y muerte celular programada.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib149\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib149\"><span class=\"anchor-text\">[149]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib150\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib150\"><span class=\"anchor-text\">[150]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib151\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib151\"><span class=\"anchor-text\">[151]<\/span><\/a>. Varios estudios han demostrado que la muerte celular programada juega un papel importante en el proceso patol\u00f3gico de la isquemia cerebral y la lesi\u00f3n por isquemia-reperfusi\u00f3n, y est\u00e1 entrelazada y estrechamente relacionada con los mecanismos anteriores, especialmente la piroptosis.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib152\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib152\"><span class=\"anchor-text\">[152]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib153\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib153\"><span class=\"anchor-text\">[153]<\/span><\/a>. La muerte celular programada es el principal evento del ictus isqu\u00e9mico, que afecta a neuronas,\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la microgl\u00eda en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microglia\">microgl\u00eda<\/a>, astrocitos,\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las c\u00e9lulas endoteliales vasculares en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascular-endothelial-cell\">c\u00e9lulas endoteliales vasculares<\/a>, etc., como la apoptosis.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib154\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib154\"><span class=\"anchor-text\">[154]<\/span><\/a>, autofagia\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib155\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib155\"><span class=\"anchor-text\">[155]<\/span><\/a>, necrosis programada o necroptosis\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib156\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib156\"><span class=\"anchor-text\">[156]<\/span><\/a>,\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la ferroptosis en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ferroptosis\">ferroptosis<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib157\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib157\"><span class=\"anchor-text\">[157]<\/span><\/a>y piroptosis\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib158\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib158\"><span class=\"anchor-text\">[158]<\/span><\/a>. Especialmente en la piroptosis, la expresi\u00f3n de prote\u00ednas relacionadas con la piroptosis, como NLRP1, ASC, Caspasa-1 y GSDMD, aumenta en un modelo de isquemia cerebral en ratas, y la inhibici\u00f3n de NLRP1 puede aliviar la inflamaci\u00f3n y las enfermedades cerebrales.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la lesi\u00f3n isqu\u00e9mica en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemic-injury\">lesi\u00f3n isqu\u00e9mica<\/a>. Adem\u00e1s, en caso de isquemia cerebral cr\u00f3nica, las c\u00e9lulas promueven respuestas inflamatorias mediante la liberaci\u00f3n de se\u00f1ales como DAMP y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre PAMP en las p\u00e1ginas de temas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathogen-associated-molecular-pattern\">PAMP<\/a>y desencadenar una serie de respuestas moleculares complejas. En este momento, las c\u00e9lulas inflamatorias neuroinmunes intracraneales, como la microgl\u00eda y los astrocitos, parecen proliferar y activarse, lo que da\u00f1a a\u00fan m\u00e1s la unidad neurovascular.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib159\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib159\"><span class=\"anchor-text\">[159]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib160\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib160\"><span class=\"anchor-text\">[160]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib161\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib161\"><span class=\"anchor-text\">[161]<\/span><\/a>.<\/p>\n<section id=\"sec0070\">\n<h3 id=\"sect0090\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">3.1. Piroptosis y neuronas<\/h3>\n<p id=\"p0115\">Despu\u00e9s de IS, se produce necrosis en el \u00e1rea isqu\u00e9mica central en poco tiempo y las c\u00e9lulas muertas liberan se\u00f1ales de peligro como\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la prote\u00edna HMGB1 en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/high-mobility-group-b1-protein\">prote\u00edna HMGB1<\/a>,\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la prote\u00edna de choque t\u00e9rmico en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/heat-shock-protein\">prote\u00edna de choque t\u00e9rmico<\/a>,\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la peroxidasa en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/peroxidase\">peroxidasa<\/a>\u00a0prote\u00edna familiar, etc. Estas mol\u00e9culas de se\u00f1al de peligro se unen a\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los receptores de reconocimiento de patrones en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pattern-recognition-receptor\">receptores de reconocimiento de patr\u00f3n<\/a>, forma\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los inflamasomas en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammasome\">inflamasomas<\/a>, inician respuestas inmunes innatas y causan muerte neuronal.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib162\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib162\"><span class=\"anchor-text\">[162]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib163\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib163\"><span class=\"anchor-text\">[163]<\/span><\/a>. Los estudios han confirmado que la isquemia cerebral puede conducir a una alta expresi\u00f3n de NLRP1 y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre NLRP3 en las p\u00e1ginas de temas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nucleotide-binding-oligomerization-domain-like-receptor\">NLRP3<\/a>\u00a0en tejido cerebral isqu\u00e9mico y neuronas, y la activaci\u00f3n de NLRP1 existe principalmente en neuronas\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib164\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib164\"><span class=\"anchor-text\">[164]<\/span><\/a>. El uso de inhibidores de caspasa-1 o preparaciones de inmunoglobulinas puede atenuar la expresi\u00f3n de NLRP1 y NLRP3 en neuronas corticales primarias y reducir el tama\u00f1o de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el infarto cerebral en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-infarction\">infarto cerebral<\/a>, y el mecanismo puede estar relacionado con la inhibici\u00f3n de la activaci\u00f3n de la v\u00eda NF-\u03baB y MAPK\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib164\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib164\"><span class=\"anchor-text\">[164]<\/span><\/a>. En los ratones IS, Li et al.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib165\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib165\"><span class=\"anchor-text\">[165]<\/span><\/a>\u00a0encontr\u00f3 que al tercer d\u00eda despu\u00e9s de la isquemia cerebral, el da\u00f1o ultraestructural del plasma neuronal, nuclear y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las membranas mitocondriales en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitochondrial-membrane\">membranas mitocondriales<\/a>\u00a0Ocurri\u00f3, y las expresiones de Caspasa-1, GSDMD e IL-1\u03b2 aumentaron significativamente. El inhibidor de caspasa-1\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre Vx765 en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/belnacasan\">Vx765<\/a>\u00a0Puede inhibir la piroptosis, promover la supervivencia de las neuronas en \u00e1reas isqu\u00e9micas y mejorar.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la disfunci\u00f3n cerebral en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-dysfunction\">disfunci\u00f3n cerebral<\/a>\u00a0en ratones. Liang et al.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib166\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib166\"><span class=\"anchor-text\">[166]<\/span><\/a>\u00a0descubrieron que el gen 3 de ARN largo no codificante expresado por la madre (MEG3) promueve la piroptosis y las respuestas inflamatorias al activar la v\u00eda AIM2\/Caspasa-1, lo que resulta en una lesi\u00f3n por isquemia-reperfusi\u00f3n cerebral. La eliminaci\u00f3n del gen MEG3 puede inhibir la expresi\u00f3n de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre AIM2 en las p\u00e1ginas de temas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nodular-melanoma\">AIM2<\/a>, Caspasa-1, GSDMD y otras prote\u00ednas, y alivian la lesi\u00f3n cerebral isqu\u00e9mica. Esto sugiere que MEG3 puede ser un objetivo terap\u00e9utico eficaz para el accidente cerebrovascular isqu\u00e9mico.<\/p>\n<\/section>\n<section id=\"sec0075\">\n<h3 id=\"sect0095\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">3.2. Piroptosis y astrocitos<\/h3>\n<p id=\"p0120\">Los astrocitos son los m\u00e1s abundantes.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las c\u00e9lulas gliales en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glial-cells\">c\u00e9lulas gliales<\/a>\u00a0en el\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el sistema nervioso central en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/central-nervous-system\">sistema nervioso central<\/a>\u00a0y est\u00e1n involucrados en la formaci\u00f3n de la barrera hematoencef\u00e1lica, regulando el metabolismo neuronal y estabilizando la comunicaci\u00f3n intercelular.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib167\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib167\"><span class=\"anchor-text\">[167]<\/span><\/a>. Despu\u00e9s de IS, un cambio patol\u00f3gico prominente es reactivo\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la astrogliosis en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/astrocytosis\">astrogliosis<\/a>\u00a0y cicatrizaci\u00f3n glial, que promueven la plasticidad neuronal poco despu\u00e9s de la lesi\u00f3n isqu\u00e9mica\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib168\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib168\"><span class=\"anchor-text\">[168]<\/span><\/a>. Generalmente se cree que cuando el\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el hipocampo en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hippocampus\">hipocampo<\/a>\u00a0es isquemia y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la hipoxia en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hypoxia\">hipoxia<\/a>, el\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la capacidad antioxidante en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antioxidant-capacity\">capacidad antioxidante<\/a>\u00a0del hipocampo se debilitar\u00e1 y es posible que se libere una gran cantidad de factores inflamatorios, agravando as\u00ed el da\u00f1o al hipocampo\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib169\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib169\"><span class=\"anchor-text\">[169]<\/span><\/a>. Tres (3) h despu\u00e9s de la isquemia cerebral focal en\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las ratas SD en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/sprague-dawley-rat\">ratas SD<\/a>, aparecieron c\u00e9lulas inmunorreactivas positivas similares a IL-1\u03b2 en el \u00e1rea isqu\u00e9mica, principalmente astrocitos inactivados. Hasta 2 meses despu\u00e9s de la isquemia, las c\u00e9lulas positivas todav\u00eda se pueden detectar en el hemisferio isqu\u00e9mico, especialmente alrededor de los focos necr\u00f3ticos, y cuanto mayor sea el grado de activaci\u00f3n.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib170\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib170\"><span class=\"anchor-text\">[170]<\/span><\/a>. Los astrocitos activados pueden inducir la liberaci\u00f3n de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el factor de necrosis tumoral en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tumor-necrosis-factor\">factor de necrosis tumoral<\/a>, interleucina, factor de crecimiento y otros factores inflamatorios o mediadores t\u00f3xicos neuronales, que provocan da\u00f1o neuronal\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib171\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib171\"><span class=\"anchor-text\">[171]<\/span><\/a>. NLRP2 se expresa principalmente en astrocitos, pero apenas se expresa en neuronas y microgl\u00eda. Adem\u00e1s, la expresi\u00f3n de NLRP2 se regul\u00f3 significativamente en el modelo de isquemia cerebral de rat\u00f3n y despu\u00e9s de la privaci\u00f3n de ox\u00edgeno y glucosa en astrocitos, y silenciar NLRP2 podr\u00eda reducir la piroptosis inducida por la privaci\u00f3n de ox\u00edgeno y glucosa.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib172\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib172\"><span class=\"anchor-text\">[172]<\/span><\/a>. Otro estudio encontr\u00f3 que en un modelo in vitro de isquemia cerebral, la privaci\u00f3n de ox\u00edgeno y glucosa provoc\u00f3 un aumento de NLRP3, ASC, Caspasa-1, IL-1\u03b2 e IL-18, y una disminuci\u00f3n de la supervivencia de los astrocitos.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la hispidulina en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hispidulin\">hispidulina<\/a>\u00a0es un compuesto cet\u00f3nico aislado de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la medicina herbaria china en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chinese-herbal-medicine\">medicina herbaria china<\/a>. Experimentos in vitro e in vivo han demostrado que la hispidulina puede inhibir la piroptosis mediada por NLRP3 y ejercer un efecto protector en el cerebro, y su mecanismo est\u00e1 relacionado con la activaci\u00f3n de AMPK\/GSK-3\u03b2.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la v\u00eda de se\u00f1alizaci\u00f3n en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/signal-transduction\">v\u00eda de se\u00f1alizaci\u00f3n<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib173\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib173\"><span class=\"anchor-text\">[173]<\/span><\/a>. Meng et al.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib174\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib174\"><span class=\"anchor-text\">[174]<\/span><\/a>\u00a0encontraron que la expresi\u00f3n de NLRP6 alcanz\u00f3 un pico a las 48 h despu\u00e9s de la isquemia-reperfusi\u00f3n cerebral en ratas. Despu\u00e9s de la privaci\u00f3n de ox\u00edgeno y glucosa en los astrocitos, aumenta la producci\u00f3n de NLRP6 y sus productos de activaci\u00f3n, y silenciar NLRP6 puede reducir ASC y Caspasa-1, reducir la liberaci\u00f3n de factores inflamatorios y aumentar la actividad neuronal.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib175\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib175\"><span class=\"anchor-text\">[175]<\/span><\/a>. Por lo tanto, las intervenciones dirigidas a la activaci\u00f3n del inflamasoma en los astrocitos pueden proporcionar nuevas ideas para el tratamiento del IS.<\/p>\n<\/section>\n<section id=\"sec0080\">\n<h3 id=\"sect0100\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">3.3. Piroptosis y microgl\u00eda<\/h3>\n<p id=\"p0125\">La microgl\u00eda es innata.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las c\u00e9lulas inmunitarias en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunocompetent-cell\">c\u00e9lulas inmunes<\/a>\u00a0del sistema nervioso central y las primeras c\u00e9lulas activadas despu\u00e9s del accidente cerebrovascular isqu\u00e9mico\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib176\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib176\"><span class=\"anchor-text\">[176]<\/span><\/a>. En la fase aguda de la lesi\u00f3n por isquemia cerebral, la microgl\u00eda migra r\u00e1pidamente al sitio de la lesi\u00f3n y secreta factores inflamatorios y sustancias citot\u00f3xicas, agravando el da\u00f1o tisular.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib177\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib177\"><span class=\"anchor-text\">[177]<\/span><\/a>. En la fase cr\u00f3nica, la microgl\u00eda puede producir citoquinas antiinflamatorias y factores de crecimiento para promover\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la reparaci\u00f3n de tejidos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tissue-repair\">reparaci\u00f3n de tejidos<\/a>\u00a0y remodelaci\u00f3n\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib178\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib178\"><span class=\"anchor-text\">[178]<\/span><\/a>. Los estudios han encontrado que la piroptosis microglial juega un papel importante en la lesi\u00f3n cerebral isqu\u00e9mica. NLRC4 fue el primer inflamasoma que aument\u00f3 significativamente cuando la microgl\u00eda fue privada de ox\u00edgeno y glucosa durante 3 h, mientras que NLRP1, NLRP3 y AIM2 no aumentaron significativamente hasta despu\u00e9s de 6 h de privaci\u00f3n de ox\u00edgeno y glucosa. Silenciar NLRC4 puede reducir la producci\u00f3n de GSDMD, IL-1\u03b2 e IL-18 e inhibir la piroptosis microglial\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib179\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib179\"><span class=\"anchor-text\">[179]<\/span><\/a>. Xu et al.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib180\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib180\"><span class=\"anchor-text\">[180]<\/span><\/a>\u00a0inform\u00f3 que el receptor conductor 1 (TREM-1) expresado por\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las c\u00e9lulas mieloides en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/myeloid-cell\">c\u00e9lulas mieloides<\/a>\u00a0en la microglia despu\u00e9s de la isquemia-reperfusi\u00f3n cerebral puede activar la v\u00eda de piroptosis mediada por NLRP3\/Caspasa-1 e inducir respuestas neuroinflamatorias. La inhibici\u00f3n de TREM-1 reduce la piroptosis microglial y el da\u00f1o a los nervios. Li y col.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib181\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib181\"><span class=\"anchor-text\">[181]<\/span><\/a>\u00a0Confirmaron que la expresi\u00f3n de la guanosina monofosfato-adenosina sintasa c\u00edclica (cGAS) est\u00e1 regulada positivamente despu\u00e9s de la isquemia cerebral y activa el inflamasoma AIM2 para inducir la piroptosis microglial. El antagonista de cGAS A151 puede inhibir la activaci\u00f3n de AIM2 y la piroptosis microglial, reducir significativamente el volumen del infarto cerebral y aliviar el da\u00f1o a los nervios. Los estudios anteriores indican que la piroptosis de la microgl\u00eda y su respuesta neuroinflamatoria mediada pueden ser un mecanismo importante que conduce a una lesi\u00f3n cerebral isqu\u00e9mica. La inhibici\u00f3n de los efectos neurot\u00f3xicos de la microgl\u00eda puede ser una nueva estrategia para el tratamiento del accidente cerebrovascular isqu\u00e9mico.<\/p>\n<\/section>\n<section id=\"sec0085\">\n<h3 id=\"sect0105\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">3.4. Piroptosis y c\u00e9lulas endoteliales.<\/h3>\n<p id=\"p0130\">Las c\u00e9lulas endoteliales constituyen la primera barrera de la barrera hematoencef\u00e1lica y proporcionan soporte para\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre claudin en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/claudin\">claud\u00edn<\/a>,\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las mol\u00e9culas de adhesi\u00f3n en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-adhesion-molecule\">mol\u00e9culas de adhesi\u00f3n<\/a>\u00a0y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la matriz extracelular en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/extracellular-matrix\">la matriz extracelular<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib182\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib182\"><span class=\"anchor-text\">[182]<\/span><\/a>. Durante la isquemia cerebral, la respuesta inmunoinflamatoria y el estr\u00e9s oxidativo pueden da\u00f1ar\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las c\u00e9lulas endoteliales en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/endothelial-cell\">c\u00e9lulas endoteliales<\/a>\u00a0y alterar la integridad de la barrera hematoencef\u00e1lica, lo que provoca edema vasog\u00e9nico, transformaci\u00f3n hemorr\u00e1gica y aumento de la mortalidad.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib183\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib183\"><span class=\"anchor-text\">[183]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib184\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib184\"><span class=\"anchor-text\">[184]<\/span><\/a>. Despu\u00e9s de la isquemia cerebral, el NLRP3 se regula positivamente en las neuronas, la microgl\u00eda y las c\u00e9lulas endoteliales vasculares, y el silenciamiento del gen NLRP3 puede reducir el volumen del infarto cerebral en ratones con\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la arteria cerebral media en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/middle-cerebral-artery\">arteria cerebral media<\/a>\u00a0isquemia y reducir la permeabilidad de la barrera hematoencef\u00e1lica\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib185\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib185\"><span class=\"anchor-text\">[185]<\/span><\/a>. Wang y cols.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib186\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib186\"><span class=\"anchor-text\">[186]<\/span><\/a>\u00a0Confirm\u00f3 que la isquemia cerebral puede inducir piroptosis de c\u00e9lulas endoteliales microvasculares y agravar la lesi\u00f3n por isquemia-reperfusi\u00f3n. Tambi\u00e9n encontraron que la activaci\u00f3n del coactivador 1\u03b1 del receptor gamma activado por el proliferador de peroxisomas (PGC-1\u03b1) reduc\u00eda significativamente la expresi\u00f3n de prote\u00ednas relacionadas con la piroptosis y aumentaba la expresi\u00f3n de ZO-1 y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre Occludin en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/occludin\">Ocludina<\/a>\u00a0prote\u00ednas en las c\u00e9lulas endoteliales microvasculares del cerebro, para proteger la integridad de la barrera hematoencef\u00e1lica. Adem\u00e1s, los estudios han encontrado que la piroptosis de las c\u00e9lulas endoteliales microvasculares cerebrales puede aumentar la posibilidad de hemorragia despu\u00e9s de la IS, lo que lleva a complicaciones graves como\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la hemorragia cerebral en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebral-hemorrhage\">hemorragia cerebral<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib187\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib187\"><span class=\"anchor-text\">[187]<\/span><\/a>.<\/p>\n<div>\n<p id=\"p0135\">La asociaci\u00f3n entre isquemia cerebral y piroptosis se resume en\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#fig0010\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"fig0010\"><span class=\"anchor-text\">Figura 2<\/span><\/a>.<\/p>\n<figure id=\"fig0010\" class=\"figure text-xs\"><img decoding=\"async\" src=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr2.jpg\" alt=\"Fig. 2\" height=\"362\" aria-describedby=\"cap0010\" \/><\/p>\n<ol class=\"u-margin-s-bottom\">\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"Descargar imagen de alta resoluci\u00f3n (274 KB)\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr2_lrg.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">Descargar :\u00a0<span class=\"download-link-title\">Descargar imagen de alta resoluci\u00f3n (274 KB)<\/span><\/span><\/a><\/li>\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"Descargar imagen en tama\u00f1o completo\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr2.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">Descargar :\u00a0<span class=\"download-link-title\">Descargar imagen en tama\u00f1o completo<\/span><\/span><\/a><\/li>\n<\/ol>\n<p id=\"sp0010\"><span class=\"label\">Figura 2<\/span>. Resumen del mecanismo de piroptosis en unidades neuronales vasculares despu\u00e9s de IS [Mecanismo molecular de piroptosis en unidades neuronales vasculares (consta de microgl\u00eda, astrocitos, neuronas,\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las c\u00e9lulas endoteliales vasculares en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascular-endothelial-cell\">c\u00e9lulas endoteliales vasculares<\/a>, pericitos) despu\u00e9s de IS. FRI:\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el factor regulador del interfer\u00f3n en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/interferon-regulatory-factor\">factor regulador de interfer\u00f3n<\/a>; IFN:\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el interfer\u00f3n en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/interferon\">Interfer\u00f3n<\/a>; CASP: caspasa; GPX4: glutati\u00f3n peroxidasa 4].<\/p>\n<\/figure>\n<\/div>\n<\/section>\n<\/section>\n<section id=\"sec0090\">\n<h2 id=\"sect0110\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">4. Potencial de los inhibidores de la piroptosis para tratar el IS<\/h2>\n<p id=\"p0140\">En los \u00faltimos a\u00f1os, la investigaci\u00f3n de inhibidores de piroptosis en IS ha recibido mucha atenci\u00f3n. Liang et al.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib188\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib188\"><span class=\"anchor-text\">[188]<\/span><\/a>\u00a0descubri\u00f3 que el inhibidor de Caspasa-1 VX-765 puede reducir Caspasa-1, ASC, GSDMD e IL-1\u03b2, mientras regula positivamente los niveles de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las prote\u00ednas de uni\u00f3n estrecha en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tight-junction-protein\">prote\u00ednas de uni\u00f3n estrecha<\/a>\u00a0y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los inhibidores tisulares de metaloproteinasas en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/metalloprotease-inhibitor\">inhibidores tisulares de metaloproteinasas<\/a>, protegiendo la integridad de la barrera hematoencef\u00e1lica. Adem\u00e1s, VX-765 tambi\u00e9n promueve la transformaci\u00f3n de la microgl\u00eda del tipo M1 al tipo M2, reduce la respuesta inflamatoria mediada por la microgl\u00eda y ejerce un efecto neuroprotector.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib189\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib189\"><span class=\"anchor-text\">[189]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib190\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib190\"><span class=\"anchor-text\">[190]<\/span><\/a>. MCC950 es un inhibidor selectivo de NLRP3. Los estudios han encontrado que MCC950 puede reducir la expresi\u00f3n de NLRP3, Caspasa-1 e IL-1\u03b2 en la penumbra isqu\u00e9mica y tiene un efecto protector sobre la isquemia cerebral focal en ratones.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib191\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib191\"><span class=\"anchor-text\">[191]<\/span><\/a>. Los estudios han encontrado que algunos\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los microARN en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microrna\">microARN<\/a>\u00a0puede inhibir la piroptosis en el modelo de isquemia cerebral y desempe\u00f1ar un papel neuroprotector\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib192\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib192\"><span class=\"anchor-text\">[192]<\/span><\/a>. LP17 puede inhibir\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las c\u00e9lulas mieloides en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/myeloid-cell\">c\u00e9lula mieloide<\/a>\u00a0desencadenar el receptor 1, inhibiendo as\u00ed el estr\u00e9s oxidativo y la piroptosis, y reduciendo el da\u00f1o neuronal inducido por la isquemia cerebral\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib192\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib192\"><span class=\"anchor-text\">[192]<\/span><\/a>.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la histidina en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/histidine\">histidina<\/a>\u00a0puede inhibir la piroptosis mediada por NLRP3 regulando la v\u00eda de se\u00f1alizaci\u00f3n de la prote\u00edna quinasa activada por adenilato\/gluc\u00f3geno sintasa quinasa-3\u03b2, ejerciendo as\u00ed efectos neuroprotectores anti-CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib193\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib193\"><span class=\"anchor-text\">[193]<\/span><\/a>. Los receptores de lipoprote\u00ednas de baja densidad pueden inhibir la piroptosis neuronal mediada por NLRP3 despu\u00e9s de CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib194\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib194\"><span class=\"anchor-text\">[194]<\/span><\/a>. El eje 1 del receptor \u03b1-glutamato oxaloacetato transaminasa activado por el proliferador de peroxisoma mediado por alcohol lip\u00eddico puede inhibir la piroptosis de las c\u00e9lulas endoteliales despu\u00e9s de la IS y mejorar la lesi\u00f3n cerebral isqu\u00e9mica\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib195\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib195\"><span class=\"anchor-text\">[195]<\/span><\/a>. La sobreexpresi\u00f3n de CHRFAM7A puede inhibir la piroptosis microglial dependiente de la v\u00eda NLRP3\/caspasa-1 y atenuar CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib196\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib196\"><span class=\"anchor-text\">[196]<\/span><\/a>. Los reguladores de la gluc\u00f3lisis y la apoptosis inducida por TP53 pueden aliviar la piroptosis microglial inducida por la isquemia cerebral y la lesi\u00f3n cerebral isqu\u00e9mica\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib197\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib197\"><span class=\"anchor-text\">[197]<\/span><\/a>. Adem\u00e1s,\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los exosomas en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/exosome\">exosomas<\/a>\u00a0derivado de m\u00e9dula \u00f3sea hip\u00f3xica\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las c\u00e9lulas madre mesenquimales en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mesenchymal-stem-cell\">c\u00e9lulas madre mesenquimales<\/a>\u00a0puede modular el fenotipo microglial M1\/M2 para aliviar la piroptosis neuronal inducida por CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib198\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib198\"><span class=\"anchor-text\">[198]<\/span><\/a>. Precondicionado por hipoxia\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la mucosa olfativa en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/olfactory-mucosa\">mucosa olfatoria<\/a>\u00a0Las c\u00e9lulas madre mesenquimales pueden inhibir la piroptosis y la apoptosis de la microgl\u00eda causada por la isquemia cerebral al activar el factor 1\u03b1 inducible por hipoxia, reduciendo as\u00ed el CIRI.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib199\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib199\"><span class=\"anchor-text\">[199]<\/span><\/a>.<\/p>\n<p id=\"p0145\">Como ejecutor de piroptosis, GSDMD es un objetivo molecular ideal para el tratamiento de IS. Sin embargo, la investigaci\u00f3n actual sobre los inhibidores de GSDMD est\u00e1 todav\u00eda en sus primeras etapas y faltan pruebas de la eficacia de los inhibidores de GSDMD en el tratamiento del accidente cerebrovascular isqu\u00e9mico. Estudios recientes han encontrado que algunos componentes naturales de las plantas pueden tratar el IS regulando la v\u00eda piropt\u00f3tica.<\/p>\n<\/section>\n<section id=\"sec0095\">\n<h2 id=\"sect0115\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">5. Los productos naturales como nuevos inhibidores de la piroptosis y, por tanto, se convierten en candidatos potenciales para el tratamiento del IS.<\/h2>\n<p id=\"p0150\">Los productos naturales tienen ventajas significativas en la prevenci\u00f3n y el tratamiento del infarto cerebral\/isquemia-reperfusi\u00f3n cerebral debido a sus ventajas de multicomponente, multiobjetivo, multicanal y baja toxicidad, y tienen buenas perspectivas de aplicaci\u00f3n. Actualmente, la investigaci\u00f3n de productos naturales en la prevenci\u00f3n y tratamiento del infarto cerebral\/CIRI est\u00e1 aumentando paulatinamente, involucrando una variedad de mecanismos protectores. Esta secci\u00f3n resumi\u00f3 los productos naturales, modelos animales o celulares, m\u00e9todos de administraci\u00f3n, dosis de administraci\u00f3n, tiempo de tratamiento, efectos y mecanismos de tratamiento (v\u00edas de se\u00f1alizaci\u00f3n) para brindar respaldo te\u00f3rico para la b\u00fasqueda r\u00e1pida de componentes vegetales naturales que sean seguros, efectivos y de baja toxicidad. y regular la piroptosis para la prevenci\u00f3n y el tratamiento de IS\/CIRI.<\/p>\n<section id=\"sec0100\">\n<h3 id=\"sect0120\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">5.1. Componentes naturales de las plantas.<\/h3>\n<div>\n<p id=\"p0155\">La estructura principal de los componentes naturales de las plantas se muestra en\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#fig0015\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"fig0015\"><span class=\"anchor-text\">Fig. 3<\/span><\/a>.<\/p>\n<figure id=\"fig0015\" class=\"figure text-xs\"><img decoding=\"async\" src=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr3.jpg\" alt=\"Fig. 3\" height=\"397\" aria-describedby=\"cap0015\" \/><\/p>\n<ol class=\"u-margin-s-bottom\">\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"Descargar imagen de alta resoluci\u00f3n (208KB)\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr3_lrg.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">Descargar :\u00a0<span class=\"download-link-title\">Descargar imagen de alta resoluci\u00f3n (208KB)<\/span><\/span><\/a><\/li>\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"Descargar imagen en tama\u00f1o completo\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr3.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">Descargar :\u00a0<span class=\"download-link-title\">Descargar imagen en tama\u00f1o completo<\/span><\/span><\/a><\/li>\n<\/ol>\n<p id=\"sp0015\"><span class=\"label\">Fig. 3<\/span>. La estructura principal de los componentes vegetales naturales.<\/p>\n<\/figure>\n<\/div>\n<section id=\"sec0105\">\n<h4 id=\"sect0125\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.1. Gastrodina (GAS)<\/h4>\n<p id=\"p0160\">GAS es un compuesto multifuncional derivado de la hierba,\u00a0<em><a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre Gastrodia elata en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/gastrodia-elata\">gastrodia elata<\/a><\/em>, con varios\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las actividades farmacol\u00f3gicas en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/pharmacological-activity\">actividades farmacol\u00f3gicas<\/a>, como actividades antioxidantes y antiinflamatorias. Adem\u00e1s, se ha demostrado que GAS reduce significativamente los s\u00edntomas de isquemia-reperfusi\u00f3n cerebral mediante la modulaci\u00f3n de factores proapopt\u00f3ticos que incluyen la escisi\u00f3n de caspasa-3, IL-18 e IL-1\u03b2. Varios estudios han demostrado que GAS mejora la lesi\u00f3n isqu\u00e9mica cerebral y reduce los niveles de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las especies reactivas de ox\u00edgeno en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/reactive-oxygen-species\">especies de ox\u00edgeno reactivas<\/a>\u00a0y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las citoquinas inflamatorias en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammatory-cytokine\">citocinas inflamatorias<\/a>\u00a0en ratones\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib200\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib200\"><span class=\"anchor-text\">[200]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib201\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib201\"><span class=\"anchor-text\">[201]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib202\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib202\"><span class=\"anchor-text\">[202]<\/span><\/a>. Lu y col. descubri\u00f3 que GAS podr\u00eda mejorar la piroptosis asociada con la lesi\u00f3n por isquemia-reperfusi\u00f3n microvascular card\u00edaca al apuntar al eje NLRP3\/caspasa-1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib203\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib203\"><span class=\"anchor-text\">[203]<\/span><\/a>. GAS puede mejorar significativamente la\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la funci\u00f3n neurol\u00f3gica en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nervous-system-physiology\">funci\u00f3n neurol\u00f3gica<\/a>\u00a0puntuar y reducir el tama\u00f1o de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el infarto cerebral en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-infarction\">infarto cerebral<\/a>. Mientras tanto, GAS inhibi\u00f3 la piroptosis mediante la regulaci\u00f3n negativa de NLRP3, factores inflamatorios (IL-1\u03b2, IL-18) y caspasa-1 escindida. Adem\u00e1s, GAS atenu\u00f3 la inflamaci\u00f3n de las c\u00e9lulas neuronales inducida por isquemia-reperfusi\u00f3n mediante la regulaci\u00f3n del eje lncRNA NEAT1 \/ miR-22-3p. GAS atenu\u00f3 significativamente la lesi\u00f3n por isquemia-reperfusi\u00f3n cerebral mediante la regulaci\u00f3n del eje lncRNA NEAT1 \/ miR-22-3p\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib204\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib204\"><span class=\"anchor-text\">[204]<\/span><\/a>. Por lo tanto, el GAS puede usarse como potencial\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los medicamentos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chemotherapeutic-agent\">droga<\/a>\u00a0para el tratamiento de CIRI.<\/p>\n<\/section>\n<section id=\"sec0110\">\n<h4 id=\"sect0130\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.2. Tanshinona IIA<\/h4>\n<p id=\"p0165\"><a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre Tanshinone IIA en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tanshinone-iia\">Tanshinona IIA<\/a>\u00a0es el principal componente activo de\u00a0<em><a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre Salvia miltiorrhiza en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/salvia-miltiorrhiza\">Salvia miltiorrhiza<\/a><\/em>. Es ampliamente utilizado en el tratamiento de enfermedades cardiovasculares y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las enfermedades cerebrovasculares en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebrovascular-disease\">enfermedades cerebrovasculares<\/a>\u00a0debido a sus efectos antioxidantes y mejoradores de la circulaci\u00f3n. Cai et al.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib205\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib205\"><span class=\"anchor-text\">[205]<\/span><\/a>\u00a0descubrieron que la tanshinona IIA reduc\u00eda eficazmente la expresi\u00f3n de IL-1\u03b2 e IL-18 en la v\u00eda de se\u00f1alizaci\u00f3n inflamatoria NLRP3, y su efecto depende de la dosis. Esto sugiere que la tanshinona IIA inhibe la activaci\u00f3n de la v\u00eda de se\u00f1alizaci\u00f3n NLRP3, reduciendo as\u00ed el da\u00f1o de la privaci\u00f3n\/reperfusi\u00f3n de ox\u00edgeno y glucosa en las c\u00e9lulas BV-2 despu\u00e9s del accidente cerebrovascular.<\/p>\n<\/section>\n<section id=\"sec0115\">\n<h4 id=\"sect0135\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.3. Leonurina<\/h4>\n<p id=\"p0170\"><a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la leonurina en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/leonurine\">Leonurina<\/a>\u00a0en\u00a0<em><a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre Leonuri en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/leonurus\">leonuri<\/a><\/em><em>\u00a0hierba<\/em>\u00a0mejor\u00f3 la capacidad de aprendizaje y la capacidad de memoria de ratas con isquemia cerebral cr\u00f3nica y redujo la expresi\u00f3n de NLRP3. Se especula que el prop\u00f3sito de proteger los nervios se puede lograr mediante un efecto antiinflamatorio. La activaci\u00f3n de NLRP3 promovi\u00f3 la conversi\u00f3n del precursor de Caspasa-1 en Caspasa-1 y promovi\u00f3 la producci\u00f3n de IL-1\u03b2 e IL-18, provocando as\u00ed una serie de respuestas inflamatorias. La leonurina puede reducir la respuesta inflamatoria en el tejido cerebral, reducir la puntuaci\u00f3n del d\u00e9ficit neurol\u00f3gico al inhibir la piroptosis de las c\u00e9lulas y tiene un buen efecto neuroprotector.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib206\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib206\"><span class=\"anchor-text\">[206]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0120\">\n<h4 id=\"sect0140\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.4. paeoniflorina<\/h4>\n<p id=\"p0175\"><a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre Paeoniflorin en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/paeoniflorin\">paeoniflorina<\/a>\u00a0proviene del componente principal de\u00a0<em><a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre Paeoniae radix rubra en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/radix-paeoniae-rubra\">Paeoniae radix rubra<\/a><\/em>. Paeoniflorin es el principal componente activo de los gluc\u00f3sidos totales de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la peon\u00eda en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/paeonia\">peon\u00eda<\/a>\u00a0(TGP), que tambi\u00e9n tiene buenas actividades antiinflamatorias e inmunomoduladoras.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib207\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib207\"><span class=\"anchor-text\">[207]<\/span><\/a>. TGP y paeoniflorin tambi\u00e9n tienen diversas actividades farmacol\u00f3gicas como\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los antiespasm\u00f3dicos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antispasmodic\">antiespasm\u00f3dico<\/a>,\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los analg\u00e9sicos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/anodyne\">analg\u00e9sico<\/a>, y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la vasodilataci\u00f3n en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vasodilatation\">vasodilataci\u00f3n<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib208\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib208\"><span class=\"anchor-text\">[208]<\/span><\/a>. Zulifiya Ekemu et al. descubri\u00f3 que despu\u00e9s de una isquemia-reperfusi\u00f3n cerebral aguda, la activaci\u00f3n de la microgl\u00eda y la piroptosis neuronal en el cerebro era obvia, la activaci\u00f3n de NLRP3 aumentaba y la caspasa-1 y la IL-1\u03b2 estaban reguladas positivamente.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib209\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib209\"><span class=\"anchor-text\">[209]<\/span><\/a>. Paeoniflorin redujo significativamente las puntuaciones de funci\u00f3n neurol\u00f3gica, redujo significativamente\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el tama\u00f1o del infarto cerebral en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-infarction-size\">tama\u00f1o del infarto cerebral<\/a>, expresi\u00f3n de Iba1 significativamente disminuida y estado neuronal significativamente mejorado. Adem\u00e1s, las expresiones de NLRP3, Caspasa-1 e IL-1\u03b2 disminuyeron significativamente despu\u00e9s de la intervenci\u00f3n con paeoniflorina. Se sugiere que la paeoniflorina puede reducir la activaci\u00f3n de la microgl\u00eda, inhibir la piroptosis neuronal y mejorar el da\u00f1o neurol\u00f3gico mediado por ACI al inhibir la activaci\u00f3n de NLRP3 y Caspasa-1.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib209\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib209\"><span class=\"anchor-text\">[209]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0125\">\n<h4 id=\"sect0145\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.5. Butilftalida<\/h4>\n<p id=\"p0180\"><span class=\"small-caps\">l<\/span>La -butilftalida se aisl\u00f3 por primera vez de semillas de berro y luego pudo sintetizarse artificialmente.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la butilftalida en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/butylphthalide\">Butilftalida<\/a>\u00a0tiene un doble papel \u00fanico, que no s\u00f3lo puede reconstruir\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la microcirculaci\u00f3n en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microcirculation\">microcirculaci\u00f3n<\/a>\u00a0y aumentar la reperfusi\u00f3n de isquemia, protegiendo as\u00ed la integridad de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la estructura vascular en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/blood-vessel\">estructura vascular<\/a>, restaurando el di\u00e1metro vascular, aumentando el flujo sangu\u00edneo en el \u00e1rea isqu\u00e9mica y el n\u00famero de alrededores\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los microvasos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microvessel\">microvasos<\/a>, pero tambi\u00e9n protege las mitocondrias y reduce la muerte celular, protegiendo as\u00ed la integridad de la estructura mitocondrial, mejorando la actividad de la enzima IV del complejo mitocondrial, mejorando la actividad de la enzima ATP mitocondrial y manteniendo la estabilidad de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la membrana mitocondrial en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitochondrial-membrane\">membrana mitocondrial<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib210\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib210\"><span class=\"anchor-text\">[210]<\/span><\/a>. El \u00faltimo estudio muestra que la butilftalida puede afectar la piroptosis en ratas CIRI de manera dosis dependiente a trav\u00e9s de la v\u00eda de se\u00f1alizaci\u00f3n del inflamasoma NLRP3.<\/p>\n<\/section>\n<section id=\"sec0130\">\n<h4 id=\"sect0150\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.6. Breviscapina<\/h4>\n<p id=\"p0185\"><a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la breviscapina en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/breviscapine\">Breviscapina<\/a>\u00a0se extrae de\u00a0<em><a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre Erigeron breviscapus en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/erigeron-breviscapus\">Erigeron breviscapus<\/a><\/em>\u00a0(Vant.) Mano. -Mazz. La breviscapina es una mezcla de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la escutelarina en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/scutellarin\">escutelarina<\/a>\u00a0Contiene principalmente escutelarina con una peque\u00f1a cantidad de escutelarina, que tiene las funciones de dilatar los vasos sangu\u00edneos cerebrales, reducir la resistencia cerebrovascular, aumentar el flujo sangu\u00edneo cerebral, mejorar la microcirculaci\u00f3n y resistir.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la agregaci\u00f3n plaquetaria en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/thrombocyte-aggregation\">la agregaci\u00f3n plaquetaria<\/a>. Las \u00faltimas investigaciones muestran que la breviscapina inhibi\u00f3 significativamente la activaci\u00f3n de las c\u00e9lulas inflamatorias NLRP3 en el\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el hipocampo en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hippocampus\">hipocampo<\/a>\u00a0de ratas CCI, regula negativamente la expresi\u00f3n de las prote\u00ednas Caspasa 1, IL-6 e IL-1\u03b2, inhibe la activaci\u00f3n de la prote\u00edna Caspasa-3 e inhibe\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la apoptosis neuronal en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroapoptosis\">apoptosis neuronal<\/a>. Esto sugiere que la breviscapina puede mejorar significativamente la funci\u00f3n cognitiva de las ratas CCI y reducir el da\u00f1o patol\u00f3gico de las neuronas isqu\u00e9micas, y su mecanismo puede estar relacionado con la inhibici\u00f3n de la activaci\u00f3n del inflamasoma NLRP3 y la v\u00eda de piroptosis en el tejido cerebral.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib211\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib211\"><span class=\"anchor-text\">[211]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0135\">\n<h4 id=\"sect0155\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.7. resveratrol<\/h4>\n<p id=\"p0190\"><a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el resveratrol en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/resveratrol\">resveratrol<\/a>\u00a0es un no flavonoide\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los compuestos polifen\u00f3licos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/polyphenol-derivative\">compuesto polifen\u00f3lico<\/a>. Fue aislado por primera vez de las ra\u00edces de\u00a0<em><a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre Veratrum en las p\u00e1ginas de temas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/veratrum\">Veratrum<\/a><\/em><em>\u00a0grandiflorum<\/em>y se ha encontrado resveratrol en m\u00e1s de 700 plantas. Los estudios han demostrado que el resveratrol juega un papel importante en la regulaci\u00f3n del estr\u00e9s oxidativo en el infarto cerebral, inhibiendo la inflamaci\u00f3n y mejorando el cerebro.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la neuroprotecci\u00f3n en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroprotection\">neuroprotecci\u00f3n<\/a>. El resveratrol regula la piroptosis del tejido cerebral de isquemia-reperfusi\u00f3n principalmente a trav\u00e9s de la regulaci\u00f3n del inflamasoma microglia NLRP3, Caspasa-1 y ZO-1.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib212\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib212\"><span class=\"anchor-text\">[212]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0140\">\n<h4 id=\"sect0160\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.8. \u00c1cido salvian\u00f3lico (SAFI)<\/h4>\n<p id=\"p0195\">Estudios recientes han demostrado que SAFI aument\u00f3 significativamente las puntuaciones de d\u00e9ficit neurol\u00f3gico, redujo el volumen del infarto y atenu\u00f3 el da\u00f1o histol\u00f3gico a\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la corteza cerebral en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebral-cortex\">corteza cerebral<\/a>\u00a0y la apoptosis neuronal en el modelo MCAO\/R, aumentan la viabilidad neuronal y reducen la apoptosis neuronal en el modelo OGD. SAFI tambi\u00e9n remodel\u00f3 el patr\u00f3n de polarizaci\u00f3n microglial de un fenotipo similar a M1 a un fenotipo similar a M2 e inhibi\u00f3 la activaci\u00f3n del inflamasoma NLRP3 y la expresi\u00f3n de prote\u00ednas relacionadas con el inflamasoma\/piroxia NLRP3 in vitro e in vivo. Esto sugiere que SAFI puede ejercer efectos neuroprotectores al reducir la apoptosis neuronal, cambiar el fenotipo microglial de M1 a M2 e inhibir el eje inflamasoma\/piropt\u00f3tico NLRP3 en la microgl\u00eda.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib213\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib213\"><span class=\"anchor-text\">[213]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0145\">\n<h4 id=\"sect0165\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.9. hispidulina<\/h4>\n<p id=\"p0200\"><a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la hispidulina en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hispidulin\">hispidulina<\/a>\u00a0es un\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los flavonoides en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/flavonoid\">flavonoide<\/a>\u00a0compuesto con diversas propiedades farmacol\u00f3gicas y es uno de los principales componentes activos de muchos\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las hierbas medicinales chinas en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chinese-herbal-medicine\">Medicinas herbarias chinas<\/a>. La hispidulina tiene una amplia gama de propiedades farmacol\u00f3gicas, incluidas antioxidantes,\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los antif\u00fangicos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antifungal-agent\">antif\u00fangico<\/a>,\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los antineopl\u00e1sicos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/anticarcinogen\">antineopl\u00e1sico<\/a>, propiedades antiosteopor\u00f3ticas, antiinflamatorias y antimutag\u00e9nicas. El \u00faltimo estudio demostr\u00f3 que la hispidulina mejor\u00f3\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los s\u00edntomas neurol\u00f3gicos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neurologic-disease\">s\u00edntomas neurol\u00f3gicos<\/a>\u00a0en ratas despu\u00e9s de IRI, al tiempo que reduce el tama\u00f1o del infarto y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el edema cerebral en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-edema\">edema cerebral<\/a>. Mec\u00e1nicamente, la hispidulina ejerce sus efectos neuroprotectores in vivo e in vitro al inhibir la piroptosis mediada por NLRP3 al regular la v\u00eda de se\u00f1alizaci\u00f3n AMPK\/GSK3\u03b2.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib214\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib214\"><span class=\"anchor-text\">[214]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0150\">\n<h4 id=\"sect0170\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.10. Astragal\u00f3sido IV<\/h4>\n<p id=\"p0205\"><em><a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre Astragali Radix en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/astragalus-root\">Radix de astr\u00e1galo<\/a><\/em>\u00a0Puede complementar la deficiencia, fortalecer el bazo y el est\u00f3mago, promover la circulaci\u00f3n sangu\u00ednea y promover la circulaci\u00f3n sangu\u00ednea, y puede tratar los s\u00edntomas de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la deficiencia de Qi en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/qi-deficiency\">deficiencia de qi<\/a>\u00a0y deficiencia de sangre\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib215\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib215\"><span class=\"anchor-text\">[215]<\/span><\/a>.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el astragalosido IV en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/astragaloside-iv\">Astragal\u00f3sido IV<\/a>\u00a0es uno de los principales componentes activos de\u00a0<em>Radix de astr\u00e1galo<\/em>\u00a0y el\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el mon\u00f3mero en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/monomer\">mon\u00f3mero<\/a>\u00a0componente de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el astr\u00e1galo en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/astragalus\">Astr\u00e1galo<\/a>\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las saponinas en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/saponin\">saponinas<\/a>. A menudo se utiliza como est\u00e1ndar para probar la calidad del astr\u00e1galo.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib216\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib216\"><span class=\"anchor-text\">[216]<\/span><\/a>. Astragal\u00f3sido IV tiene una variedad de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las actividades biol\u00f3gicas en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/biological-activity\">actividades biol\u00f3gicas<\/a>, y el alcance de la investigaci\u00f3n involucra m\u00faltiples \u00f3rganos y tejidos como cerebro, h\u00edgado, coraz\u00f3n, pulm\u00f3n, ri\u00f1\u00f3n, est\u00f3mago, intestino, vasos sangu\u00edneos, etc.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib217\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib217\"><span class=\"anchor-text\">[217]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib218\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib218\"><span class=\"anchor-text\">[218]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib219\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib219\"><span class=\"anchor-text\">[219]<\/span><\/a>\u00a0Tiene actividades biol\u00f3gicas como antiinflamatorias, antivirus, antiapoptosis, promoviendo\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la proliferaci\u00f3n celular en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-proliferation\">proliferaci\u00f3n celular<\/a>, regulando\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la enfermedad de los conejos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/rabbit-disease\">enfermedad del conejo<\/a>, regulando el az\u00facar en la sangre, retardando el envejecimiento e inhibiendo el c\u00e1ncer.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib217\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib217\"><span class=\"anchor-text\">[217]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib218\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib218\"><span class=\"anchor-text\">[218]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib219\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib219\"><span class=\"anchor-text\">[219]<\/span><\/a>. Nuestro estudio anterior identific\u00f3 el astragal\u00f3sido IV como un posible agente neuroprotector que desempe\u00f1\u00f3 un papel importante en el tratamiento del IS. Por ejemplo, puede proteger la barrera hematoencef\u00e1lica, mejorar el metabolismo energ\u00e9tico, inhibir la apoptosis de las c\u00e9lulas nerviosas, inhibir la respuesta inflamatoria, el estr\u00e9s oxidativo y ejercer efectos neuroprotectores, mejorando as\u00ed la isquemia cerebral.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib220\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib220\"><span class=\"anchor-text\">[220]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib221\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib221\"><span class=\"anchor-text\">[221]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib222\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib222\"><span class=\"anchor-text\">[222]<\/span><\/a>. En t\u00e9rminos de piroptosis, Tang et al. descubri\u00f3 que el inflamasoma NLRP3 se activaba durante la isquemia-reperfusi\u00f3n cerebral en ratas, y la inhibici\u00f3n del inflamasoma NLRP3 o la inhibici\u00f3n de su Caspasa-1 aguas abajo podr\u00eda aliviar el da\u00f1o por isquemia-reperfusi\u00f3n cerebral en ratas.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib223\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib223\"><span class=\"anchor-text\">[223]<\/span><\/a>. El astragal\u00f3sido IV puede reducir la puntuaci\u00f3n del d\u00e9ficit neurol\u00f3gico, reducir el volumen del infarto cerebral y reducir los niveles de prote\u00ednas de NLRP3, Caspasa-1, pro-IL-1\u03b2, IL-1\u03b2, pro-IL-18 e IL-18 en el tejido cerebral. e inhibe la expresi\u00f3n de la prote\u00edna NF-\u03baB fosforilada. Esto sugiere que el astragal\u00f3sido IV tiene un efecto anti-CIRI y su mecanismo puede estar relacionado con la inhibici\u00f3n de NF-\u03baB.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la fosforilaci\u00f3n de prote\u00ednas en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/protein-phosphorylation\">fosforilaci\u00f3n de prote\u00ednas<\/a>\u00a0y la inhibici\u00f3n de la activaci\u00f3n del inflamasoma NLRP3.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib223\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib223\"><span class=\"anchor-text\">[223]<\/span><\/a>. Li y col. tambi\u00e9n encontr\u00f3 que el astragal\u00f3sido IV puede reducir el da\u00f1o cerebral inducido por hipoxia-isquemia en ratas neonatales e inhibir la respuesta inflamatoria del tejido cerebral hip\u00f3xico-isqu\u00e9mico y las neuronas del hipocampo HT22 en ratas neonatales, que puede ejercerse mediante la regulaci\u00f3n del NLRP3\/mediado por MMP-9. V\u00eda de se\u00f1alizaci\u00f3n de caspasa-1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib224\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib224\"><span class=\"anchor-text\">[224]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0155\">\n<h4 id=\"sect0175\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.11. Saponinas de Panax notoginseng (SNP)<\/h4>\n<p id=\"p0210\"><em>Notoginseng Radix y rizoma<\/em>\u00a0es la ra\u00edz seca y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el rizoma en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/rhizome\">rizoma<\/a>\u00a0de\u00a0<em><a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre Panax en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/panax\">Panax<\/a><\/em><em>\u00a0notoginsen (Burk.)<\/em>\u00a0FH Chen, que tiene actividad farmacol\u00f3gica en la sangre, el sistema cardiovascular, nervioso e inmunol\u00f3gico.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib225\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib225\"><span class=\"anchor-text\">[225]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib226\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib226\"><span class=\"anchor-text\">[226]<\/span><\/a>. El PNS es su principal ingrediente activo y contiene una variedad de saponinas monom\u00e9ricas, y sus preparaciones, como la inyecci\u00f3n de Xuesaitong, se utilizan ampliamente en la prevenci\u00f3n y el tratamiento de enfermedades cardiovasculares y cerebrovasculares.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib227\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib227\"><span class=\"anchor-text\">[227]<\/span><\/a>. Nuestros estudios previos y los estudios existentes han demostrado que el PNS tiene varios efectos farmacol\u00f3gicos en la lesi\u00f3n cerebral isqu\u00e9mica, como\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los antitromb\u00f3ticos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antithrombotic\">antitromb\u00f3tico<\/a>, antiinflamatorio, antioxidante, inhibe la apoptosis de las c\u00e9lulas nerviosas cerebrales y mejora el da\u00f1o de la barrera hematoencef\u00e1lica.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib228\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib228\"><span class=\"anchor-text\">[228]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib229\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib229\"><span class=\"anchor-text\">[229]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib230\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib230\"><span class=\"anchor-text\">[230]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib231\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib231\"><span class=\"anchor-text\">[231]<\/span><\/a>. Esto sugiere que el SNP puede desempe\u00f1ar un papel protector en la isquemia cerebral a trav\u00e9s de m\u00faltiples objetivos. Estudios recientes han encontrado que el PNS puede inhibir la activaci\u00f3n del inflamasoma NLRP3 y promover selectivamente\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la mitofagia en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitophagy\">mitofagia<\/a>\u00a0durante la isquemia-reperfusi\u00f3n cerebral en ratas. La inhibici\u00f3n de la mitofagia podr\u00eda revertir el efecto inhibidor del PNS sobre el inflamasoma NLRP3, lo que indica que la mitofagia media el efecto inhibidor del PNS sobre la activaci\u00f3n del inflamasoma NLRP3 en la isquemia-reperfusi\u00f3n cerebral. Adem\u00e1s, los niveles de las prote\u00ednas PINK1 y Parkin en las mitocondrias aumentaron durante la isquemia-reperfusi\u00f3n cerebral en ratas, y el SNP podr\u00eda aumentar a\u00fan m\u00e1s los niveles de las prote\u00ednas PINK1 y Parkin en las mitocondrias del tejido cerebral. Esto sugiere que el SNP puede promover la mitofagia en la isquemia-reperfusi\u00f3n cerebral a trav\u00e9s de la v\u00eda PINK1\/Parkin.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib232\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib232\"><span class=\"anchor-text\">[232]<\/span><\/a>. En resumen, el PNS promueve selectivamente la mitofagia a trav\u00e9s de la v\u00eda PINK1\/Parkin, inhibe la activaci\u00f3n del inflamasoma NLRP3 en la isquemia-reperfusi\u00f3n cerebral y alivia la lesi\u00f3n por isquemia-reperfusi\u00f3n cerebral.<\/p>\n<\/section>\n<\/section>\n<section id=\"sec0160\">\n<h3 id=\"sect0180\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">5.2. Extracto de plantas naturales<\/h3>\n<section id=\"sec0165\">\n<h4 id=\"sect0185\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.1. Decocci\u00f3n de Taohong Siwu (THSWD)<\/h4>\n<p id=\"p0215\">THSWD es una de las recetas cl\u00e1sicas para promover la circulaci\u00f3n sangu\u00ednea y eliminar\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la estasis sangu\u00ednea en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/blood-stasis\">estasis sangu\u00ednea<\/a>, eliminando la estasis sangu\u00ednea y regenerando sangre nueva creada por el &quot;Espejo Dorado de la Medicina&quot; de Wu Qian en la dinast\u00eda Qing. Los estudios farmacol\u00f3gicos actuales han confirmado que los principales ingredientes activos de THSWD incluyen\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el \u00e1cido fer\u00falico en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ferulic-acid\">\u00c1cido fer\u00falico<\/a>,\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el c\u00e1rtamo en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/safflower\">c\u00e1rtamo<\/a>\u00a0amarillo, y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los polisac\u00e1ridos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glycan\">polisac\u00e1ridos<\/a>. Entre ellos, el \u00e1cido fer\u00falico tiene efectos farmacol\u00f3gicos como inhibir la agregaci\u00f3n plaquetaria, antitromb\u00f3tico, antiinflamatorio y antioxidante. El amarillo de c\u00e1rtamo tiene efectos antiisquemia cerebral, isquemia antimioc\u00e1rdica, antitrombosis, antioxidante, antitumoral y otros efectos. Zhou y cols. encontr\u00f3 que THSWD mejor\u00f3 la funci\u00f3n del d\u00e9ficit neurol\u00f3gico, el volumen del infarto cerebral y la morfolog\u00eda del tejido cerebral despu\u00e9s de una lesi\u00f3n por isquemia-reperfusi\u00f3n cerebral, y redujo significativamente los niveles de las prote\u00ednas \u03b2 DRP1, NLRP3, Caspasa-1 e IL-1.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib233\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib233\"><span class=\"anchor-text\">[233]<\/span><\/a>. Indic\u00f3 que el efecto terap\u00e9utico de THSWD sobre el infarto cerebral estaba relacionado con la inhibici\u00f3n de la v\u00eda DRP1\/NLRP3 relacionada con la piroptosis. Investigaciones adicionales mostraron que los contenidos de IL-1\u03b2 e IL-18 en el grupo THSWD disminuyeron significativamente, y los niveles de NLRP3, Caspasa-1, Caspasa-1 p10, ASC, TXNIP y GSDMD disminuyeron. La detecci\u00f3n de v\u00edas de se\u00f1alizaci\u00f3n mostr\u00f3 que THSWD redujo significativamente los niveles de expresi\u00f3n de HMGB1\/RAGE, TLR4\/NF-\u03baB,\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre p38 MAPK en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/p38-mitogen-activated-protein-kinase\">p38 MAPK<\/a>\u00a0y JNK en la penumbra. En resumen, THSWD redujo el nivel de respuesta inflamatoria en ratas MCAO\/R, inhibi\u00f3 la activaci\u00f3n del inflamasoma NLRP3 en ratas MCAO\/R y regul\u00f3 negativamente GSDMD. THSWD tiene el efecto de inhibir la piroptosis, que puede verse afectada al inhibir las v\u00edas de se\u00f1alizaci\u00f3n HMGB1\/TLR4\/NF-kB y MAPK.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib234\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib234\"><span class=\"anchor-text\">[234]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0170\">\n<h4 id=\"sect0190\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.2. C\u00e1psulas de Naoxinqing (NXQC)<\/h4>\n<p id=\"p0220\">El ingrediente principal de NXQC es la hoja de\u00a0<em><a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre Diospyros kaki en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/persimmon\">Diospyros caqui<\/a><\/em>\u00a0Thunb (hoja de caqui). Los estudios han demostrado que el extracto de hoja de caqui contiene flavonoides, \u00e1cidos org\u00e1nicos y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la cumarina en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/coumarin\">cumarina<\/a>\u00a0y otros productos qu\u00edmicos, que tienen efectos antiinflamatorios, antioxidantes,\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los antihipertensivos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antihypertensive-agent\">antihipertensivo<\/a>, reducci\u00f3n de l\u00edpidos en sangre, mejora\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el m\u00fasculo liso vascular en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascular-smooth-muscle\">m\u00fasculo liso vascular<\/a>\u00a0funci\u00f3n y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la hemodin\u00e1mica en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hemodynamic\">hemodin\u00e1mico<\/a>\u00a0funci\u00f3n. El f\u00e1rmaco se ha utilizado ampliamente en el tratamiento de enfermedades cardiovasculares y cerebrovasculares.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib235\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib235\"><span class=\"anchor-text\">[235]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib236\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib236\"><span class=\"anchor-text\">[236]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib237\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib237\"><span class=\"anchor-text\">[237]<\/span><\/a>. Los estudios existentes han demostrado que NXQC puede mejorar eficazmente\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la arteriosclerosis cerebral en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebral-atherosclerosis\">arteriosclerosis cerebral<\/a>\u00a0y proteger el da\u00f1o nervioso causado por la isquemia cerebral\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib238\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib238\"><span class=\"anchor-text\">[238]<\/span><\/a>. Min y col. descubri\u00f3 que NXQC puede mejorar eficazmente la disminuci\u00f3n de la capacidad de aprendizaje despu\u00e9s de una isquemia cerebral y aumentar las actividades de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la super\u00f3xido dismutasa en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/superoxide-dismutase\">super\u00f3xido dismutasa<\/a>\u00a0y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la lactato deshidrogenasa en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/lactate-dehydrogenase\">lactato deshidrogenasa<\/a>, aumentar el contenido de GSH y reducir el contenido de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el malondialdeh\u00eddo en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/malonaldehyde\">malondialdeh\u00eddo<\/a>. NXQC tambi\u00e9n puede regular negativamente las prote\u00ednas ASC, NLRP3 y Caspasa-1 en el hipocampo y reducir significativamente los contenidos de IL-18 e IL-1\u03b2. Tambi\u00e9n encontraron que las c\u00e9lulas positivas para la mol\u00e9cula 1 de adhesi\u00f3n de c\u00e9lulas endoteliales plaquetarias en jerbos aumentaron significativamente despu\u00e9s de la intervenci\u00f3n con NXQC, y la\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las uniones intercelulares en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-junction\">uniones intercelulares<\/a>\u00a0estaban apretados. Se sugiere que NXQC puede proteger eficazmente la morfolog\u00eda de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la regi\u00f3n CA1 del hipocampo en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/sommers-sector\">regi\u00f3n CA1 del hipocampo<\/a>\u00a0de jerbos, protege la funci\u00f3n cerebrovascular y luego inhibe la lesi\u00f3n cerebral por isquemia-reperfusi\u00f3n\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib239\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib239\"><span class=\"anchor-text\">[239]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0175\">\n<h4 id=\"sect0195\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.3. Decocci\u00f3n de Buyang Huanwu (BYHWD) y sus modificaciones<\/h4>\n<p id=\"p0225\">BYHWD es un famoso\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la medicina tradicional china en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/traditional-chinese-medicine\">medicina tradicional china<\/a>\u00a0F\u00f3rmula utilizada para tratar el accidente cerebrovascular. Su prescripci\u00f3n se registr\u00f3 por primera vez en la &quot;Correcci\u00f3n de cl\u00e1sicos m\u00e9dicos&quot; de Wang Qingren en la dinast\u00eda Qing.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib240\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib240\"><span class=\"anchor-text\">[240]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib241\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib241\"><span class=\"anchor-text\">[241]<\/span><\/a>. Es un destacado representante de la prescripci\u00f3n para nutrir el qi y activar la sangre. Tiene las funciones de tonificar el qi, promover la circulaci\u00f3n sangu\u00ednea y dragar las colaterales. Sus estudios de medicina basada en evidencia han demostrado buenos efectos cl\u00ednicos.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib242\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib242\"><span class=\"anchor-text\">[242]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib243\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib243\"><span class=\"anchor-text\">[243]<\/span><\/a>. Nuestro estudio anterior mostr\u00f3 que BYHWD\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los gluc\u00f3sidos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glycoside\">gluc\u00f3sidos<\/a>\u00a0Puede mejorar la disfunci\u00f3n neurol\u00f3gica, reducir el da\u00f1o neuronal e inhibir la piroptosis neuronal. Los gluc\u00f3sidos de BYHWD son los ingredientes activos extra\u00eddos de BYHWD, que incluyen principalmente astragal\u00f3sido IV, paeoniflorina y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la am\u00edgdala en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/amygdalin\">amigdalina<\/a>. Es el principal ingrediente farmacol\u00f3gico activo para tonificar los ri\u00f1ones y activar la sangre, y puede tratar la lesi\u00f3n del nervio isqu\u00e9mico cerebral.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib244\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib244\"><span class=\"anchor-text\">[244]<\/span><\/a>. Adem\u00e1s, observamos que los gluc\u00f3sidos BYHWD inhibieron significativamente la expresi\u00f3n de las prote\u00ednas NLRP3, ASC, pro-caspasa-1, caspasa-1 e IL-1\u03b2 de la v\u00eda de piroptosis can\u00f3nica mediada por NLRP3.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib209\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib209\"><span class=\"anchor-text\">[209]<\/span><\/a>. En resumen, los gluc\u00f3sidos BYHWD ejercen efectos neuroprotectores al inhibir la piroptosis neuronal despu\u00e9s de CIRI, que est\u00e1 estrechamente relacionada con la regulaci\u00f3n de la v\u00eda piropt\u00f3tica cl\u00e1sica por NLRP3. Adem\u00e1s, Longzhi\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la decocci\u00f3n en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/decoction\">Decocci\u00f3n<\/a>\u00a0es una f\u00f3rmula emp\u00edrica formada por BYHWD con sanguijuelas y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre Achyranthes en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/achyranthes\">Aquiranthes<\/a>\u00a0sichuanensis. Se ha utilizado en el tratamiento cl\u00ednico del accidente cerebrovascular agudo durante muchos a\u00f1os y el efecto es muy bueno.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib245\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib245\"><span class=\"anchor-text\">[245]<\/span><\/a>. Estudios recientes han demostrado que la decocci\u00f3n de Longzhi tiene efectos obvios en la mejora de los s\u00edntomas neurol\u00f3gicos en ratas despu\u00e9s de CIRI, mantiene el estado de las c\u00e9lulas nerviosas en el tejido cerebral y reduce el volumen del infarto cerebral. En t\u00e9rminos de intervenci\u00f3n de piroptosis celular, Longzhi Decoction puede mejorar los s\u00edntomas de las ratas despu\u00e9s de CIRI y proteger\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el da\u00f1o a las c\u00e9lulas nerviosas en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nerve-cell-lesion\">da\u00f1o de las c\u00e9lulas nerviosas<\/a>\u00a0despu\u00e9s de una lesi\u00f3n al regular negativamente la expresi\u00f3n de las prote\u00ednas Caspasa-1 e IL-18\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib245\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib245\"><span class=\"anchor-text\">[245]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0180\">\n<h4 id=\"sect0200\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.4. Receta de Yiqi Huoxue (YQHXP)<\/h4>\n<p id=\"p0230\">YQHXP consta de\u00a0<em>Radix Angelicae Sinensis, Radix Astragali,\u00a0<\/em><em><a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el rizoma de Chuanxiong en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ligusticum-chuanxiong-extract\">Rizoma de Chuanxiong<\/a><\/em><em>, Escorpio, Leonuri Herba, Acori Tatarinowii Rhizoma, Borneolum Syntheticum<\/em>, y ha logrado buenos resultados cl\u00ednicos\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib246\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib246\"><span class=\"anchor-text\">[246]<\/span><\/a>. Los estudios en animales han demostrado que YQHXP mejor\u00f3 las puntuaciones de la funci\u00f3n neurol\u00f3gica y las tasas de infarto cerebral en ratas, y redujo los niveles de IL-1\u03b2, TNF-\u03b1 e IL-18 en el tejido cerebral, y la expresi\u00f3n relativa de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre P2RX7 en las p\u00e1ginas de temas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/p2rx7\">P2RX7<\/a>, Caspasa-1, Caspasa-11 y GSDMD en tejido de penumbra isqu\u00e9mica cerebral. Despu\u00e9s de la intervenci\u00f3n YQHXP, la exudaci\u00f3n inflamatoria y el edema del tejido cerebral se redujeron significativamente y mejoraron la morfolog\u00eda celular y la degeneraci\u00f3n vacuolar neuronal. En resumen, YQHXP puede reducir la inflamaci\u00f3n del tejido cerebral en ratas con accidente cerebrovascular isqu\u00e9mico agudo al inhibir la piroptosis.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib247\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib247\"><span class=\"anchor-text\">[247]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0185\">\n<h4 id=\"sect0205\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.5. Decocci\u00f3n de Shen Nao Fu Yuan (SNFYD)<\/h4>\n<p id=\"p0235\">SNFYD es una receta eficaz para el accidente cerebrovascular isqu\u00e9mico basada en la teor\u00eda del tratamiento simult\u00e1neo del ri\u00f1\u00f3n y el cerebro. Su composici\u00f3n es:\u00a0<em>Radix de astr\u00e1galo<\/em>\u00a030 gramos<em>,\u00a0<\/em><em><a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre Rehmanniae en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/rehmannia\">Rehmanniae<\/a><\/em><em>\u00a0Radix praeparata<\/em>\u00a010 gramos<em>, Corni Fructus<\/em>\u00a010 gramos<em>, Dioscoreae rizoma<\/em>\u00a015 gramos<em>, Rhodiolae Crenulatae Radix y Rhizoma<\/em>\u00a020 gramos<em>,\u00a0<\/em><em><a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre Moutan Cortex en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/moutan-cortex\">corteza de monta\u00f1a<\/a><\/em>\u00a010 gramos<em>, Angelicae Sinensis Radix<\/em>\u00a010 gramos<em>, Paeoniae radix rubra<\/em>\u00a010 gramos<em>,\u00a0<\/em><em><a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre Pheretima en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/pheretima\">fer\u00e9tima<\/a><\/em>\u00a010 gramos\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib248\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib248\"><span class=\"anchor-text\">[248]<\/span><\/a>. Se combina con una gran cantidad de medicamentos que tonifican el qi, reponen la esencia y tonifican los ri\u00f1ones, que se combinan con la activaci\u00f3n de la sangre y el dragado de colaterales. Los estudios han demostrado que despu\u00e9s del modelado OGD, la PC12 result\u00f3 significativamente da\u00f1ada y varias citocinas en la v\u00eda de la piroptosis aumentaron significativamente.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib249\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib249\"><span class=\"anchor-text\">[249]<\/span><\/a>. Despu\u00e9s de que el suero que contiene SNFYD y el INF39 intervinieran en pacientes da\u00f1ados\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre las c\u00e9lulas PC12 en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pc12-cell-line\">c\u00e9lulas PC12<\/a>, se mejoraron la morfolog\u00eda y la actividad de las c\u00e9lulas PC12 y, en consecuencia, se debilit\u00f3 la activaci\u00f3n de la v\u00eda de piroptosis NLRP3\/Caspasa-1. Indic\u00f3 que la inhibici\u00f3n de esta v\u00eda estaba relacionada con la mejora del estado celular, y tanto SNFYD como INF39 podr\u00edan inhibir la activaci\u00f3n de esta v\u00eda. Se sugiere que SNFYD puede reducir la apoptosis inflamatoria de las c\u00e9lulas nerviosas al inhibir NLRP3\/Caspasa-1 y la v\u00eda de piroptosis posterior, protegiendo as\u00ed el tejido nervioso y logrando el prop\u00f3sito de tratar el infarto cerebral.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib250\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib250\"><span class=\"anchor-text\">[250]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0190\">\n<h4 id=\"sect0210\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.6. Otros extractos<\/h4>\n<p id=\"p0240\">Adem\u00e1s, estudios recientes han demostrado que los f\u00e1rmacos antitromb\u00f3ticos como la heparina pueden mejorar la lesi\u00f3n pulmonar al inhibir la piroptosis. Por ejemplo, Yang et al. descubri\u00f3 que la heparina inhibe la apoptosis de las c\u00e9lulas endoteliales pulmonares al bloquear la activaci\u00f3n de caspasa-11 inducida por hMGB1 LPS, lo que puede ser una forma potencial de tratar la lesi\u00f3n pulmonar inducida por sepsis\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib251\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib251\"><span class=\"anchor-text\">[251]<\/span><\/a>. Prathapan et al. descubri\u00f3 que el agua de coco tierno tiene efectos antioxidantes y antitromb\u00f3ticos en un\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el infarto de miocardio experimental en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/experimental-myocardial-infarction\">infarto de miocardio experimental<\/a>\u00a0modelo\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib252\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib252\"><span class=\"anchor-text\">[252]<\/span><\/a>, mientras que el jugo de coco tierno puede reducir significativamente algunas de las patolog\u00edas asociadas con\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la enfermedad de Alzheimer en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/alzheimer-disease\">enfermedad de alzheimer<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib253\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib253\"><span class=\"anchor-text\">[253]<\/span><\/a>. Se indica que el agua de coco puede ser un inhibidor potencial de la piroptosis, y en el futuro se puede estudiar su papel en la regulaci\u00f3n de la piroptosis en la IS.<\/p>\n<p id=\"p0245\"><span class=\"small-caps\">l<\/span>La arginina es un compuesto org\u00e1nico presente en\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la protamina en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/protamine\">protamina<\/a>\u00a0en grandes cantidades\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib254\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib254\"><span class=\"anchor-text\">[254]<\/span><\/a>. Es un precursor de la s\u00edntesis de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el \u00f3xido n\u00edtrico en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nitric-oxide\">\u00f3xido n\u00edtrico<\/a>\u00a0(NO), que protege el endotelio intacto de los vasos sangu\u00edneos, act\u00faa como\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los vasodilatadores en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vasodilator-agent\">vasodilatador<\/a>\u00a0y una mol\u00e9cula antiateroscler\u00f3tica end\u00f3gena\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib254\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib254\"><span class=\"anchor-text\">[254]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib255\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib255\"><span class=\"anchor-text\">[255]<\/span><\/a>. Los experimentos con animales muestran que\u00a0<span class=\"small-caps\">l<\/span>-la arginina puede tener complejos\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la anticoagulaci\u00f3n en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/anticoagulation\">anticoagulaci\u00f3n<\/a>, anticoagulaci\u00f3n y\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la fibrin\u00f3lisis en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/fibrinolysis\">fibrin\u00f3lisis<\/a>\u00a0efectos\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib255\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib255\"><span class=\"anchor-text\">[255]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib256\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib256\"><span class=\"anchor-text\">[256]<\/span><\/a>. En ratas hipertensas, Cylwik et al. encontrado que\u00a0<span class=\"small-caps\">l<\/span>La -arginina podr\u00eda reducir la presi\u00f3n arterial en ratas y el tratamiento a largo plazo acort\u00f3 el tiempo de disoluci\u00f3n del co\u00e1gulo de euglobulina y el tiempo de sangrado e inhibi\u00f3 la agregaci\u00f3n plaquetaria inducida por col\u00e1geno. Se sugiere que\u00a0<span class=\"small-caps\">l<\/span>-arginina desempe\u00f1a un efecto antitromb\u00f3tico en un modelo de rata hipertensa de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la trombosis venosa en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/phlebothrombosis\">trombosis venosa<\/a>\u00a0de manera compleja\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib256\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib256\"><span class=\"anchor-text\">[256]<\/span><\/a>. Un estudio reciente demostr\u00f3 que\u00a0<span class=\"small-caps\">l<\/span>-arginina puede ser un inhibidor potencial de la piroptosis: Tanuseputero et al. sugerido que\u00a0<span class=\"small-caps\">l<\/span>-arginina puede inhibir parcialmente el inflamasoma NLRP3 para aliviar la sepsis inducida\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la lesi\u00f3n renal aguda en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/acute-kidney-injury\">Lesi\u00f3n renal aguda<\/a>\u00a0en ratones\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib257\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib257\"><span class=\"anchor-text\">[257]<\/span><\/a>. En vista de las actividades vasodilatadoras, antitromb\u00f3ticas e inhibidoras del inflamasoma NLRP3 de\u00a0<span class=\"small-caps\">l<\/span>-arginina, se sugiere que\u00a0<span class=\"small-caps\">l<\/span>La -arginina puede tener el potencial de aumentar el flujo sangu\u00edneo en el \u00e1rea isqu\u00e9mica e inhibir la piroptosis en el IS.<\/p>\n<div>\n<p id=\"p0250\">El resumen de los productos naturales que regulan la piroptosis se muestra en\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#tbl0010\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"tbl0010\"><span class=\"anchor-text\">Tabla 2<\/span><\/a>.<\/p>\n<div id=\"tbl0010\" class=\"tables colsep-0 rowsep-0 frame-topbot\">\n<p id=\"sp0025\"><span class=\"label\">Tabla 2<\/span>. El resumen de compuestos naturales que regulan la piroptosis.<\/p>\n<div class=\"groups\">\n<table>\n<thead>\n<tr class=\"rowsep-1\">\n<th scope=\"col\">Productos naturales<\/th>\n<th scope=\"col\">Modelo\/Enfermedad<\/th>\n<th scope=\"col\">Especies<\/th>\n<th scope=\"col\">Efectos<\/th>\n<th scope=\"col\">Referencia<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<th scope=\"row\">gastrodin<\/th>\n<td>Oclusi\u00f3n\/reperfusi\u00f3n de la arteria cerebral media (MCAO\/R), privaci\u00f3n\/reoxigenaci\u00f3n de ox\u00edgeno-glucosa (OGD\/R)<\/td>\n<td>Rattus norvegicus y neuronas corticales rimarias de Rattus norvegicus<\/td>\n<td>Inhibe la piroptosis mediante la regulaci\u00f3n negativa de NLRP3, factores inflamatorios (IL-1\u03b2, IL-18) y caspasa-1 escindida; regula el eje lncRNA NEAT1\/miR-22\u20133p y el eje lncRNA NEAT1\/miR-22\u20133p<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib204\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib204\"><span class=\"anchor-text\">[204]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Tanshinona IIA<\/th>\n<td>OGD\/R<\/td>\n<td>C\u00e9lulas BV2 (microgl\u00eda de Mus musculus)<\/td>\n<td>Reduce la expresi\u00f3n de IL-1\u03b2 e IL-18 en la v\u00eda de se\u00f1alizaci\u00f3n inflamatoria NLRP3<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib205\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib205\"><span class=\"anchor-text\">[205]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Leonurina<\/th>\n<td>MCAO<\/td>\n<td>Rattus norvegicus<\/td>\n<td>Reduce la expresi\u00f3n de NLRP3.<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib206\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib206\"><span class=\"anchor-text\">[206]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">paeoniflorina<\/th>\n<td>MCAO<\/td>\n<td>Rattus norvegicus<\/td>\n<td>Inhibe el nivel de NLRP3, Caspasa-1 e IL-1\u03b2<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib209\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib209\"><span class=\"anchor-text\">[209]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Butilftalida<\/th>\n<td>MCAO<\/td>\n<td>Rattus norvegicus<\/td>\n<td>Regula la v\u00eda de se\u00f1alizaci\u00f3n del inflamasoma NLRP3.<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib210\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib210\"><span class=\"anchor-text\">[210]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Breviscapina<\/th>\n<td>MCAO\/R<\/td>\n<td>Rattus norvegicus<\/td>\n<td>Inhibe la activaci\u00f3n de las c\u00e9lulas inflamatorias NLRP3 en el hipocampo de ratas CCI, regula negativamente la expresi\u00f3n de las prote\u00ednas Caspasa 1, IL-6 e IL-1\u03b2, inhibe la activaci\u00f3n de la prote\u00edna Caspasa-3<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib211\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib211\"><span class=\"anchor-text\">[211]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">resveratrol<\/th>\n<td>MCAO\/R<\/td>\n<td>Rattus norvegicus<\/td>\n<td>Regula el inflamasoma microglia NLRP3, Caspasa-1 y ZO-1.<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib212\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib212\"><span class=\"anchor-text\">[212]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u00e1cido salvian\u00f3lico<\/th>\n<td>MCAO\/R y OGD\/R<\/td>\n<td>Rattus norvegicus y microglia de Rattus norvegicus<\/td>\n<td>Inhibe la activaci\u00f3n del inflamasoma NLRP3 y la expresi\u00f3n de prote\u00ednas relacionadas con el inflamasoma\/piroxia NLRP3.<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib213\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib213\"><span class=\"anchor-text\">[213]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">hispidulina<\/th>\n<td>MCAO<\/td>\n<td>Rattus norvegicus<\/td>\n<td>Inhibe la piroptosis mediada por NLRP3 regulando la v\u00eda de se\u00f1alizaci\u00f3n AMPK\/GSK3\u03b2<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib214\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib214\"><span class=\"anchor-text\">[214]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Astragal\u00f3sido IV<\/th>\n<td>MCAO\/R<\/td>\n<td>Rattus norvegicus<\/td>\n<td>Inhibe la activaci\u00f3n del inflamasoma NLRP3; reduce los niveles de prote\u00ednas de NLRP3, Caspasa-1, pro-IL-1\u03b2, IL-1\u03b2, pro-IL-18 e IL-18 en el tejido cerebral; inhibe la expresi\u00f3n de la prote\u00edna NF-\u03baB fosforilada<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib223\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib223\"><span class=\"anchor-text\">[223]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Saponinas de Panax notoginseng<\/th>\n<td>MCAO\/R<\/td>\n<td>Rattus norvegicus<\/td>\n<td>Regula la v\u00eda PINK1\/Parkin; inhibe la activaci\u00f3n del inflamasoma NLRP3<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib232\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib232\"><span class=\"anchor-text\">[232]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Decocci\u00f3n de Taohong Siwu<\/th>\n<td>MCAO<\/td>\n<td>Rattus norvegicus<\/td>\n<td>Reduce los niveles de las prote\u00ednas \u03b2 DRP1, NLRP3, Caspasa-1 e IL-1<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib233\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib233\"><span class=\"anchor-text\">[233]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Decocci\u00f3n de Taohong Siwu<\/th>\n<td>MCAO\/R<\/td>\n<td>Rattus norvegicus<\/td>\n<td>Inhibe las v\u00edas de se\u00f1alizaci\u00f3n HMGB1\/TLR4\/NF-kB y MAPK<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib234\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib234\"><span class=\"anchor-text\">[234]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">C\u00e1psulas de Naoxinqing<\/th>\n<td>MCAO\/R<\/td>\n<td>Meriones unguiculatus<\/td>\n<td>Regula a la baja las prote\u00ednas ASC, NLRP3 y Caspasa-1; Reduce los contenidos de IL-18 e IL-1\u03b2.<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib239\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib239\"><span class=\"anchor-text\">[239]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Decocci\u00f3n de Buyang Huanwu<\/th>\n<td>MCAO\/R<\/td>\n<td>Rattus norvegicus<\/td>\n<td>Inhibe la expresi\u00f3n de las prote\u00ednas NLRP3, ASC, pro-caspasa-1, caspasa-1 e IL-1\u03b2 de la v\u00eda de piroptosis can\u00f3nica mediada por NLRP3<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib244\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib244\"><span class=\"anchor-text\">[244]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Decocci\u00f3n de Longzhi<\/th>\n<td>MCAO\/R<\/td>\n<td>Rattus norvegicus<\/td>\n<td>Regula a la baja la expresi\u00f3n de las prote\u00ednas Caspasa-1 e IL-18.<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib245\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib245\"><span class=\"anchor-text\">[245]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Receta de Yiqi Huoxue<\/th>\n<td>MCAO<\/td>\n<td>Rattus norvegicus<\/td>\n<td>Reduce los niveles de IL-1\u03b2, TNF-\u03b1 e IL-18 y la expresi\u00f3n relativa de P2RX7, Caspasa-1, Caspasa-11 y GSDMD.<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib247\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib247\"><span class=\"anchor-text\">[247]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Decocci\u00f3n de Shen Nao Fu Yuan<\/th>\n<td>OGD<\/td>\n<td>C\u00e9lulas PC12 de Rattus norvegicus<\/td>\n<td>Inhibe NLRP3\/Caspasa-1<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib250\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib250\"><span class=\"anchor-text\">[250]<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/section>\n<\/section>\n<section id=\"sec0195\">\n<h2 id=\"sect0215\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">6. Perspectivas<\/h2>\n<p id=\"p0255\">Nuestro equipo de investigaci\u00f3n ha estudiado durante mucho tiempo el modo de muerte celular programada de varios grupos de c\u00e9lulas (como neuronas, microglia y astrocitos) en la unidad neural vascular despu\u00e9s de IS. En combinaci\u00f3n con otros informes de investigaci\u00f3n, encontramos que varios modos de muerte celular, como apoptosis, ferroptosis y autofagia, ocurrieron despu\u00e9s de IS, y que la morfolog\u00eda de la apoptosis y la piroptosis ten\u00eda ciertas similitudes.\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la neuroinflamaci\u00f3n en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroinflammation\">Neuroinflamaci\u00f3n<\/a>\u00a0despu\u00e9s de IS es el proceso patol\u00f3gico m\u00e1s importante que conduce a una lesi\u00f3n cerebral, en el que la piroptosis es una parte importante de la neuroinflamaci\u00f3n. Esto sugiere que la piroptosis es anormalmente importante en la muerte celular programada relacionada con la neuroinflamaci\u00f3n despu\u00e9s de una isquemia cerebral. Las v\u00edas de se\u00f1alizaci\u00f3n relacionadas desencadenadas por la piroptosis tambi\u00e9n se cruzan con otras v\u00edas de muerte celular programada, lo que sugiere que el desarrollo de f\u00e1rmacos dirigidos a la piroptosis es una forma importante de tratar el IS.<\/p>\n<p id=\"p0260\">Para el estudio actual, todav\u00eda hay \u00e1reas de mejora: (1) Debido a los problemas de normalizaci\u00f3n y unificaci\u00f3n en el modelo animal del estudio actual, las conclusiones sobre la piroptosis en diferentes c\u00e9lulas del\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre el sistema nervioso en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nervous-system\">sistema nervioso<\/a>\u00a0son inconsistentes. Por lo tanto, en el futuro la investigaci\u00f3n sobre piroptosis requiere un modelo estable m\u00e1s estandarizado y unificado en modelos animales de accidente cerebrovascular isqu\u00e9mico, que tambi\u00e9n pueda determinar el efecto real de los f\u00e1rmacos antipiroptosis. (2) Los estudios futuros pueden verificar los efectos protectores del cerebro a largo plazo de los compuestos naturales y los mecanismos que regulan la piroptosis en una variedad de modelos de accidentes cerebrovasculares en roedores y mam\u00edferos grandes. En el futuro, se deber\u00e1 prestar m\u00e1s atenci\u00f3n a la\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre farmacocin\u00e9tica en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pharmacokinetics\">farmacocin\u00e9tica<\/a>,\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre farmacodin\u00e1mica en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pharmacodynamics\">farmacodinamia<\/a>y propiedades toxicol\u00f3gicas de los compuestos naturales que actualmente modulan la piroptosis. (3) Adem\u00e1s, en el futuro es necesario explorar el efecto sin\u00e9rgico de la combinaci\u00f3n de compuestos naturales en la regulaci\u00f3n de la piroptosis en el accidente cerebrovascular isqu\u00e9mico cerebral y el efecto neuroprotector de la inhibici\u00f3n de la neuroinflamaci\u00f3n. (4) Si todos los resultados son favorables, el siguiente paso es realizar\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los ensayos cl\u00ednicos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/clinical-trial\">ensayos cl\u00ednicos<\/a>\u00a0de potencial\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre los fitoqu\u00edmicos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/phytochemical\">fitoqu\u00edmicos<\/a>\u00a0para investigar sus efectos neuroprotectores sobre la isquemia cerebral\/accidente cerebrovascular (por ejemplo, el equipo est\u00e1 realizando actualmente un ensayo cl\u00ednico de Naotai Fang en el tratamiento de la enfermedad cerebral de peque\u00f1os vasos: ChiCTR1900024524).<\/p>\n<\/section>\n<section id=\"sec0200\">\n<h2 id=\"sect0220\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">7. Resumen<\/h2>\n<p id=\"p0265\">La piroptosis, como muerte celular programada proinflamatoria, juega un papel importante en el proceso patol\u00f3gico del accidente cerebrovascular isqu\u00e9mico al inducir la muerte celular y la neuroinflamaci\u00f3n principalmente a trav\u00e9s de la v\u00eda piropt\u00f3tica cl\u00e1sica mediada por Caspasa-1. La relaci\u00f3n entre las v\u00edas piropt\u00f3ticas no can\u00f3nicas y el IS a\u00fan no se ha dilucidado. Otros mecanismos de piroptosis requieren m\u00e1s estudios en el futuro. En la actualidad, los estudios han confirmado que\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la orientaci\u00f3n a f\u00e1rmacos en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/drug-delivery-system\">drogas dirigidas<\/a>\u00a0Las prote\u00ednas clave de la v\u00eda de la piroptosis pueden aliviar la lesi\u00f3n cerebral isqu\u00e9mica hasta cierto punto, pero su investigaci\u00f3n se limita principalmente a experimentos con c\u00e9lulas y animales, y hay una falta de\u00a0<a class=\"topic-link\" title=\"Obtenga m\u00e1s informaci\u00f3n sobre la investigaci\u00f3n cl\u00ednica en las p\u00e1ginas tem\u00e1ticas generadas por IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/clinical-research\">investigaci\u00f3n cl\u00ednica<\/a>\u00a0evidencia. Por lo tanto, se espera que m\u00e1s investigaciones cl\u00ednicas para explorar el mecanismo regulador de la piroptosis en IS proporcionen nuevas estrategias terap\u00e9uticas y bases te\u00f3ricas para la prevenci\u00f3n y el tratamiento del accidente cerebrovascular isqu\u00e9mico. Con respecto a la regulaci\u00f3n de la piroptosis por compuestos naturales, a trav\u00e9s de nuestra generalizaci\u00f3n, se puede encontrar que los compuestos vegetales naturales pueden regular la isquemia cerebral al regular la piroptosis no solo en un solo componente. Tambi\u00e9n se puede observar que los compuestos vegetales naturales multicomponentes exhiben posibles efectos sin\u00e9rgicos en la modulaci\u00f3n de la cascada inflamatoria desencadenada por la piroptosis. Esto nos inspira a estudiar en el futuro los efectos reguladores de varios compuestos naturales sobre la neuroinflamaci\u00f3n mediada por piroptosis causada por diferentes v\u00edas de se\u00f1alizaci\u00f3n.<\/p>\n<\/section>\n<section id=\"sec0205\">\n<h2 id=\"sect0225\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">Declaraci\u00f3n de contribuci\u00f3n de autor\u00eda CRediT<\/h2>\n<p id=\"p0270\"><strong>Kailin Yang:<\/strong>\u00a0Conceptualizaci\u00f3n, Metodolog\u00eda, An\u00e1lisis formal, Investigaci\u00f3n, Escritura \u2013 borrador original;\u00a0<strong>Liuting Zeng:<\/strong>\u00a0Conceptualizaci\u00f3n, Metodolog\u00eda, Software, An\u00e1lisis formal, Investigaci\u00f3n, Redacci\u00f3n \u2013 borrador original;\u00a0<strong>Jinsong Zeng:<\/strong>\u00a0Metodolog\u00eda, An\u00e1lisis formal, Investigaci\u00f3n;\u00a0<strong>Hormigueo Bao:<\/strong>\u00a0Metodolog\u00eda, An\u00e1lisis formal, Investigaci\u00f3n, Redacci\u00f3n \u2013 borrador original;\u00a0<strong>Xiaoyuan:<\/strong>\u00a0Metodolog\u00eda, An\u00e1lisis formal, Investigaci\u00f3n;\u00a0<strong>Shan Shan Wang:<\/strong>\u00a0Metodolog\u00eda, An\u00e1lisis formal, Investigaci\u00f3n;\u00a0<strong>Wang Xiang:<\/strong>\u00a0Metodolog\u00eda, An\u00e1lisis formal, Investigaci\u00f3n;\u00a0<strong>Hao Xu:<\/strong>\u00a0Metodolog\u00eda, An\u00e1lisis formal, Investigaci\u00f3n;\u00a0<strong>Jinwen Ge:<\/strong>\u00a0Conceptualizaci\u00f3n, Metodolog\u00eda, An\u00e1lisis formal, Investigaci\u00f3n, Escritura \u2013 revisi\u00f3n y edici\u00f3n.<\/p>\n<\/section>\n<\/div>\n<section id=\"coi0005\">\n<h2 id=\"sect0230\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">Declaracion de conflicto de interes<\/h2>\n<p id=\"p0275\">Los autores declaran que no tienen intereses financieros en competencia ni relaciones personales conocidas que pudieran haber influido en el trabajo presentado en este art\u00edculo.<\/p>\n<\/section>\n<section id=\"ack0005\">\n<h2 id=\"sect0235\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">Agradecimientos<\/h2>\n<p id=\"p0280\">Este trabajo cuenta con el apoyo de la\u00a0<span id=\"gs1\">Fundaci\u00f3n Nacional de Ciencias Naturales de China<\/span>\u00a0(<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs1\"><span class=\"anchor-text\">81774174<\/span><\/a>), el\u00a0<span id=\"gs2\">Proyecto nacional clave de investigaci\u00f3n y desarrollo de China<\/span>\u00a0(No.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs2\"><span class=\"anchor-text\">2018YFC1704904<\/span><\/a>),\u00a0<span id=\"gs3\">Fundaci\u00f3n Nacional de Ciencias Naturales de la provincia de Hunan<\/span>, Porcelana (<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs3\"><span class=\"anchor-text\">2020JJ5424<\/span><\/a>\u00a0y\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs3\"><span class=\"anchor-text\">2020JJ5442<\/span><\/a>),\u00a0<span id=\"gs4\">Proyecto de fondo abierto de disciplina de \u201cdoble primera clase\u201d de la Universidad de Medicina China de Hunan de medicina tradicional china y occidental integrada<\/span>\u00a0(<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs4\"><span class=\"anchor-text\">2020ZXYJH08<\/span><\/a>\u00a0y\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs4\"><span class=\"anchor-text\">2020ZXYJH09<\/span><\/a>),\u00a0<span id=\"gs5\">Proyecto del Fondo Juvenil del Departamento de Educaci\u00f3n de la provincia de Hunan<\/span>\u00a0(<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs5\"><span class=\"anchor-text\">21B0386<\/span><\/a>).<\/p>\n<\/section>\n<\/div>\n<div class=\"text-content u-font-serif\">\n<section id=\"da0005\">\n<h2 id=\"sect0020\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">Disponibilidad de datos y materiales.<\/h2>\n<p id=\"p0020\">Los datos utilizados para respaldar los hallazgos de este estudio se incluyen en el art\u00edculo.<\/p>\n<\/section>\n<\/div>\n<div class=\"Tail text-s\"><\/div>\n<section id=\"bibliog0005\" class=\"bibliography u-font-serif text-s\">\n<h2 class=\"section-title u-h4 u-margin-l-top u-margin-xs-bottom\">Referencias<\/h2>\n<section id=\"bb0005\" class=\"bibliography-sec\">\n<ol id=\"reference-links-bb0005\" class=\"references\">\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib1\" 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Furia<\/div>\n<div id=\"ref-id-sbref6\" class=\"title text-m\">Epidemiolog\u00eda y prevenci\u00f3n primaria del ictus<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Contin\u00fae. 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Res, 41 (3) (2020), p\u00e1gs. 220-230,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.24272\/j.issn.2095-8137.2020.042\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.24272\/j.issn.2095-8137.2020.042<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Ver art\u00edculo<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85084692954&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref9\"><span class=\"anchor-text\">Ver en Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=The%20pathological%20role%20of%20ferroptosis%20in%20ischemiareperfusion-related%20injury&amp;publication_year=2020&amp;author=H.F.%20Yan&amp;author=Q.Z.%20Tuo&amp;author=Q.Z.%20Yin&amp;author=P.%20Lei\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref9\"><span class=\"anchor-text\">Google Acad\u00e9mico<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib10\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib10\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[10]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">MY Wu, GT Yiang, WT Liao, AP Tsai, YL Cheng, PW Cheng, CY Li, CJ Li<\/div>\n<div id=\"ref-id-sbref10\" class=\"title text-m\">Conceptos mecanicistas actuales en la lesi\u00f3n por isquemia y reperfusi\u00f3n<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Cell PhysiolBiochem, 46 (4) (2018), p\u00e1gs. 1650-1667,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1159\/000489241\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1159\/000489241<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Ver PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">Este art\u00edculo es de acceso gratuito.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85046014150&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref10\"><span class=\"anchor-text\">Ver en Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Current%20Mechanistic%20Concepts%20in%20Ischemia%20and%20Reperfusion%20Injury&amp;publication_year=2018&amp;author=M.Y.%20Wu&amp;author=G.T.%20Yiang&amp;author=W.T.%20Liao&amp;author=A.P.%20Tsai&amp;author=Y.L.%20Cheng&amp;author=P.W.%20Cheng&amp;author=C.Y.%20Li&amp;author=C.J.%20Li\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref10\"><span class=\"anchor-text\">Google Acad\u00e9mico<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib11\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib11\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[11]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">X. 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Med Cell Longev., 2021 (2021), art\u00edculo 1587922,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1155\/2021\/1587922\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1155\/2021\/1587922<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Ver art\u00edculo<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85118990959&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref11\"><span class=\"anchor-text\">Ver en Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Targeting%20Ferroptosis%3A%20Pathological%20Mechanism%20and%20Treatment%20of%20Ischemia-Reperfusion%20Injury&amp;publication_year=2021&amp;author=X.%20Li&amp;author=N.%20Ma&amp;author=J.%20Xu&amp;author=Y.%20Zhang&amp;author=P.%20Yang&amp;author=X.%20Su&amp;author=Y.%20Xing&amp;author=N.%20An&amp;author=F.%20Yang&amp;author=G.%20Zhang&amp;author=L.%20Zhang&amp;author=Y.%20Xing\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref11\"><span class=\"anchor-text\">Google Acad\u00e9mico<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib12\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib12\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[12]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">M. Mahjoubin-Tehran, S. Rezaei, A. Jesmani, N. Birang, K. Morshedi, H. Khanbabaei, H. Khan, A. Piranviseh, M. Nejati, M. Aschner, H. Mirzaei<\/div>\n<div id=\"ref-id-sbref12\" class=\"title text-m\">Nuevos actores epigen\u00e9ticos en la patog\u00e9nesis del accidente cerebrovascular: de los ARN no codificantes a los ARN exosomales no codificantes<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Biom\u00e9dica. 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Yang, L. Zeng, A. Ge, S. Wang, J. Zeng, X. Yuan, Z. Mei, G. Wang, J. Ge<\/div>\n<div id=\"ref-id-sbref13\" class=\"title text-m\">Una revisi\u00f3n sistem\u00e1tica del progreso de la investigaci\u00f3n del ARN no codificante en la neuroinflamaci\u00f3n y la inmunorregulaci\u00f3n en el infarto cerebral\/lesi\u00f3n por isquemia-reperfusi\u00f3n.<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Frente. Immunol., 13 (2022), art\u00edculo 930171,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.3389\/fimmu.2022.930171\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.3389\/fimmu.2022.930171<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Ver art\u00edculo<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85140346409&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref13\"><span class=\"anchor-text\">Ver en Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=A%20systematic%20review%20of%20theresearch%20progress%20of%20non-coding%20RNAin%20neuroinflammation%20and%20immuneregulation%20in%20cerebral%20infarctionischemia-reperfusion%20injury&amp;publication_year=2022&amp;author=K.%20Yang&amp;author=L.%20Zeng&amp;author=A.%20Ge&amp;author=S.%20Wang&amp;author=J.%20Zeng&amp;author=X.%20Yuan&amp;author=Z.%20Mei&amp;author=G.%20Wang&amp;author=J.%20Ge\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref13\"><span class=\"anchor-text\">Google Acad\u00e9mico<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib14\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib14\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[14]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">K. 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Pharm., 154 (2022), art\u00edculo 113611,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.biopha.2022.113611\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.biopha.2022.113611<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222010009\/pdfft?md5=c10c64d3830cfc66d624f7112443f8c0&amp;pid=1-s2.0-S0753332222010009-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref14\"><span class=\"anchor-text\">Ver PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222010009\" aria-describedby=\"ref-id-sbref14\"><span class=\"anchor-text\">Ver art\u00edculo<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85137285700&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref14\"><span class=\"anchor-text\">Ver en Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=The%20mechanism%20of%20ferroptosis%20regulating%20oxidative%20stress%20in%20ischemic%20stroke%20and%20the%20regulation%20mechanism%20of%20natural%20pharmacological%20active%20components&amp;publication_year=2022&amp;author=K.%20Yang&amp;author=L.%20Zeng&amp;author=X.%20Yuan&amp;author=S.%20Wang&amp;author=A.%20Ge&amp;author=H.%20Xu&amp;author=J.%20Zeng&amp;author=J.%20Ge\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref14\"><span class=\"anchor-text\">Google Acad\u00e9mico<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib15\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib15\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[15]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">PJ Kelly, R. 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Shi, W. Gao, F. 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Chen, Z. Wei, K. Fu, Y. Duan, M. Zhang, K. Li, T. Guo, R. Yin<\/div>\n<div id=\"ref-id-sbref20\" class=\"title text-m\">Muerte celular no apopt\u00f3tica en c\u00e1ncer de ovario: tratamiento, resistencia y pron\u00f3stico<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Biom\u00e9dica. Pharm., 150 (2022), art\u00edculo 112929,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.biopha.2022.112929\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.biopha.2022.112929<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222003183\/pdfft?md5=056cbffef01439e4b2fd4ed8e4300fd4&amp;pid=1-s2.0-S0753332222003183-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref20\"><span class=\"anchor-text\">Ver PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222003183\" aria-describedby=\"ref-id-sbref20\"><span class=\"anchor-text\">Ver art\u00edculo<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85129378630&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref20\"><span class=\"anchor-text\">Ver en Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Non-apoptotic%20cell%20death%20in%20ovarian%20cancer%3A%20Treatment%2C%20resistance%20and%20prognosis&amp;publication_year=2022&amp;author=J.%20Chen&amp;author=Z.%20Wei&amp;author=K.%20Fu&amp;author=Y.%20Duan&amp;author=M.%20Zhang&amp;author=K.%20Li&amp;author=T.%20Guo&amp;author=R.%20Yin\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref20\"><span class=\"anchor-text\">Google Acad\u00e9mico<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib21\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib21\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[21]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">K. 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Gou, D. Xu, F. Li, K. Hou, W. Fang, Y. Li<\/div>\n<div id=\"ref-id-sbref22\" class=\"title text-m\">Piroptosis en el accidente cerebrovascular: nuevos conocimientos sobre los mecanismos de la enfermedad y las estrategias terap\u00e9uticas<\/div>\n<\/div>\n<div class=\"host u-font-sans\">J. 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Qu, S. Misaghi, K. Newton, LL Gilmour, S. Louie, JE Cupp, GR Dubyak, D. Hackos, VM Dixit<\/div>\n<div id=\"ref-id-sbref57\" class=\"title text-m\">Pannexin-1 es necesaria para la liberaci\u00f3n de ATP durante la apoptosis pero no para la activaci\u00f3n del inflamasoma<\/div>\n<\/div>\n<div class=\"host u-font-sans\">J. 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N\u00fa\u00f1ez<\/div>\n<div id=\"ref-id-sbref66\" class=\"title text-m\">La caspasa-11 requiere el canal pannexina-1 y el poro purin\u00e9rgico P2X7 para mediar la piroptosis y el shock endot\u00f3xico<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Inmunidad, 43 (5) (2015), p\u00e1gs. 923-932,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.immuni.2015.10.009\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.immuni.2015.10.009<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1074761315004094\/pdfft?md5=c72e71c08bd9f2b97894ca99659c6adf&amp;pid=1-s2.0-S1074761315004094-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref66\"><span class=\"anchor-text\">Ver PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1074761315004094\" aria-describedby=\"ref-id-sbref66\"><span class=\"anchor-text\">Ver art\u00edculo<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-84947441282&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref66\"><span class=\"anchor-text\">Ver en Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Caspase-11%20Requires%20the%20Pannexin-1%20Channel%20and%20the%20Purinergic%20P2X7%20Pore%20to%20Mediate%20Pyroptosis%20and%20Endotoxic%20Shock&amp;publication_year=2015&amp;author=D.%20Yang&amp;author=Y.%20He&amp;author=R.%20Mu%C3%B1oz-Planillo&amp;author=Q.%20Liu&amp;author=G.%20N%C3%BA%C3%B1ez\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref66\"><span class=\"anchor-text\">Google Acad\u00e9mico<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib67\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib67\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[67]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">F. 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Yang, PR Thompson, KA Fitzgerald<\/div>\n<div id=\"ref-id-sbref67\" class=\"title text-m\">La succinaci\u00f3n inactiva la gasdermina D y bloquea la piroptosis.<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Ciencia, 369 (6511) (2020), p\u00e1gs.1633-1637,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1126\/science.abb9818\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1126\/ciencia.abb9818<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Ver PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">Este art\u00edculo es de acceso gratuito.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Succination%20inactivates%20gasdermin%20D%20and%20blocks%20pyroptosis&amp;publication_year=2020&amp;author=F.%20Humphries&amp;author=L.%20Shmuel-Galia&amp;author=N.%20Ketelut-Carneiro&amp;author=S.%20Li&amp;author=B.%20Wang&amp;author=V.V.%20Nemmara&amp;author=R.%20Wilson&amp;author=Z.%20Jiang&amp;author=F.%20Khalighinejad&amp;author=K.%20Muneeruddin&amp;author=S.A.%20Shaffer&amp;author=R.%20Dutta&amp;author=C.%20Ionete&amp;author=S.%20Pesiridis&amp;author=S.%20Yang&amp;author=P.R.%20Thompson&amp;author=K.A.%20Fitzgerald\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref67\"><span class=\"anchor-text\">Google Acad\u00e9mico<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib68\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib68\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[68]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">BE Burdette, AN Esparza, H. 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Med, 27 (1) (2021), p\u00e1g. 39,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1186\/s10020-021-00299-y\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1186\/s10020-021-00299-y<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1008127520302352\/pdfft?md5=fb351049136416482400c5853e989211&amp;pid=1-s2.0-S1008127520302352-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref85\"><span class=\"anchor-text\">Ver PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1008127520302352\" aria-describedby=\"ref-id-sbref85\"><span class=\"anchor-text\">Ver art\u00edculo<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=LncRNA-Fendrr%20protects%20against%20the%20ubiquitination%20and%20degradation%20of%20NLRC4%20protein%20through%20HERC2%20to%20regulate%20the%20pyroptosis%20of%20microglia&amp;publication_year=2021&amp;author=L.Q.%20Wang&amp;author=Y.Y.%20Zheng&amp;author=H.J.%20Zhou&amp;author=X.X.%20Zhang&amp;author=P.%20Wu&amp;author=S.M.%20Zhu\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref85\"><span class=\"anchor-text\">Google Acad\u00e9mico<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib86\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib86\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[86]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">HS Zhang, B. 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Li, Z. Zhao, Y. Luo, T. Ning, P. Liu, Q. Chen, Y. Chu, Q. Guo, Y. Zhang, W. Zhou, H. Chen, Z. Zhou, Y. Wang, B. Su, H. You, T. Zhang, X. Li, H. Song, C. Li, T. Sun, C. Jiang<\/div>\n<div id=\"ref-id-sbref130\" class=\"title text-m\">Nanopart\u00edculas de di\u00f3xido de manganeso disfrazadas de macr\u00f3fagos para la neuroprotecci\u00f3n al reducir el estr\u00e9s oxidativo y modular el microambiente inflamatorio en el accidente cerebrovascular isqu\u00e9mico agudo<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Adv. Ciencia. (Weinh.), 8 (20) (2021), art\u00edculo e2101526,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1002\/advs.202101526\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1002\/adv.202101526<\/span><\/a><\/div>\n<div class=\"comment\">Publicaci\u00f3n electr\u00f3nica del 26 de agosto de 2021. PMID: 34436822; PMCID: PMC8529435<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Ver PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">Este art\u00edculo es de acceso gratuito.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Macrophage-disguised%20manganese%20dioxide%20nanoparticles%20for%20neuroprotection%20by%20reducing%20oxidative%20stress%20and%20modulating%20inflammatory%20microenvironment%20in%20acute%20ischemic%20stroke&amp;publication_year=2021&amp;author=C.%20Li&amp;author=Z.%20Zhao&amp;author=Y.%20Luo&amp;author=T.%20Ning&amp;author=P.%20Liu&amp;author=Q.%20Chen&amp;author=Y.%20Chu&amp;author=Q.%20Guo&amp;author=Y.%20Zhang&amp;author=W.%20Zhou&amp;author=H.%20Chen&amp;author=Z.%20Zhou&amp;author=Y.%20Wang&amp;author=B.%20Su&amp;author=H.%20You&amp;author=T.%20Zhang&amp;author=X.%20Li&amp;author=H.%20Song&amp;author=C.%20Li&amp;author=T.%20Sun&amp;author=C.%20Jiang\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref130\"><span class=\"anchor-text\">Google Acad\u00e9mico<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib132\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib132\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[132]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">Bladowski M, Gawrys J, Gajecki D, Szahidewicz-Krupska E, Sawicz-Bladowska A, Doroszko A.<\/div>\n<div id=\"ref-id-sbref131\" class=\"title text-m\">Papel de las plaquetas y la biotransformaci\u00f3n del \u00f3xido n\u00edtrico en el accidente cerebrovascular isqu\u00e9mico: una revisi\u00f3n traslativa desde el banco hasta la cama<\/div>\n<\/div>\n<div class=\"host u-font-sans\">\u00d3xido. 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Zhao, Y. Chen, H. Feng<\/div>\n<div id=\"ref-id-sbref156\" class=\"title text-m\">Muerte celular programada asociada al receptor P2X7 en la fisiopatolog\u00eda del accidente cerebrovascular hemorr\u00e1gico<\/div>\n<\/div>\n<div class=\"host u-font-sans\">CurrNeuropharmacol, 16 (9) (2018), p\u00e1gs. 1282-1295,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.2174\/1570159X16666180516094500\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.2174\/1570159X16666180516094500<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Ver art\u00edculo<\/span><\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85055080474&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref156\"><span class=\"anchor-text\">Ver en Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=P2X7%20Receptor-Associated%20Programmed%20Cell%20Death%20in%20the%20Pathophysiology%20of%20Hemorrhagic%20Stroke&amp;publication_year=2018&amp;author=H.%20Zhao&amp;author=Y.%20Chen&amp;author=H.%20Feng\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref156\"><span class=\"anchor-text\">Google Acad\u00e9mico<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib158\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib158\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[158]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">K. 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Jurajda<\/div>\n<div id=\"ref-id-sbref157\" class=\"title text-m\">El papel de la respuesta inflamatoria en la muerte celular programada asociada al accidente cerebrovascular<\/div>\n<\/div>\n<div class=\"host u-font-sans\">CurrNeuropharmacol, 16 (9) (2018), p\u00e1gs. 1365-1374,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.2174\/1570159X16666180222155833\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.2174\/1570159X16666180222155833<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Ver art\u00edculo<\/span><\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85055080999&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref157\"><span class=\"anchor-text\">Ver en Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=The%20Role%20of%20Inflammatory%20Response%20in%20Stroke%20Associated%20Programmed%20Cell%20Death&amp;publication_year=2018&amp;author=K.%20Duris&amp;author=Z.%20Splichal&amp;author=M.%20Jurajda\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref157\"><span class=\"anchor-text\">Google Acad\u00e9mico<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib159\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib159\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[159]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">DY Fann, EP Nickles, L. 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Schwarz, TV Arumugam<\/div>\n<div id=\"ref-id-sbref158\" class=\"title text-m\">La interacci\u00f3n CD137 ligando-CD137 es necesaria para la lesi\u00f3n cerebral asociada al inflamasoma despu\u00e9s de un accidente cerebrovascular isqu\u00e9mico<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Neuromolecular Med, 22 (4) (2020), p\u00e1gs.474-483,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1007\/s12017-020-08623-1\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1007\/s12017-020-08623-1<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Ver art\u00edculo<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85092632738&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref158\"><span class=\"anchor-text\">Ver en Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=CD137%20Ligand-CD137%20interaction%20is%20required%20for%20inflammasome-associated%20brain%20injury%20following%20ischemic%20stroke&amp;publication_year=2020&amp;author=D.Y.%20Fann&amp;author=E.P.%20Nickles&amp;author=L.%20Poh&amp;author=V.%20Rajeev&amp;author=S.%20Selvaraji&amp;author=H.%20Schwarz&amp;author=T.V.%20Arumugam\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref158\"><span class=\"anchor-text\">Google Acad\u00e9mico<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib160\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib160\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[160]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">V. 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Ther., 26 (9) (2020), p\u00e1gs. 925-939,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1111\/cns.13384\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1111\/cns.13384<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Ver PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">Este art\u00edculo es de acceso gratuito.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85084010416&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref164\"><span class=\"anchor-text\">Ver en Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Caspase-1%20inhibition%20prevents%20neuronal%20death%20by%20targeting%20the%20canonical%20inflammasome%20pathway%20of%20pyroptosis%20in%20a%20murine%20model%20of%20cerebral%20ischemia&amp;publication_year=2020&amp;author=J.%20Li&amp;author=J.H.%20Hao&amp;author=D.%20Yao&amp;author=R.%20Li&amp;author=X.F.%20Li&amp;author=Z.Y.%20Yu&amp;author=X.%20Luo&amp;author=X.H.%20Liu&amp;author=M.H.%20Wang&amp;author=W.%20Wang\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref164\"><span class=\"anchor-text\">Google Acad\u00e9mico<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib166\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib166\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[166]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">J. Liang, Q. Wang, JQ Li, T. Guo, D. Yu<\/div>\n<div id=\"ref-id-sbref165\" class=\"title text-m\">El ARN MEG3 largo no codificante promueve la lesi\u00f3n por isquemia-reperfusi\u00f3n cerebral mediante el aumento de la piroptosis al apuntar al eje miR-485\/AIM2<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Exp. Neurol., 325 (2020), art\u00edculo 113139,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.expneurol.2019.113139\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.expneurol.2019.113139<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014488619302869\/pdfft?md5=c32009110f4a234e536f16bbd938c229&amp;pid=1-s2.0-S0014488619302869-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref165\"><span class=\"anchor-text\">Ver PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014488619302869\" aria-describedby=\"ref-id-sbref165\"><span class=\"anchor-text\">Ver art\u00edculo<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85076270980&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref165\"><span class=\"anchor-text\">Ver en Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Long%20non-coding%20RNA%20MEG3%20promotes%20cerebral%20ischemia-reperfusion%20injury%20through%20increasing%20pyroptosis%20by%20targeting%20miR-485AIM2%20axis&amp;publication_year=2020&amp;author=J.%20Liang&amp;author=Q.%20Wang&amp;author=J.Q.%20Li&amp;author=T.%20Guo&amp;author=D.%20Yu\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref165\"><span class=\"anchor-text\">Google Acad\u00e9mico<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib167\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib167\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[167]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">D.Rossi<\/div>\n<div id=\"ref-id-sbref166\" class=\"title text-m\">Fisiopatolog\u00eda de los astrocitos: en la encrucijada de las redes intercelulares, la inflamaci\u00f3n y la muerte celular<\/div>\n<\/div>\n<div class=\"comment\">2015<\/div>\n<div class=\"host u-font-sans\">Prog. 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Neurobiol., 42 (5) (2022), p\u00e1gs. 1487-1500,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1007\/s10571-021-01040-3\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1007\/s10571-021-01040-3<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Ver art\u00edculo<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85101234736&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref190\"><span class=\"anchor-text\">Ver en Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=MircoRNA-29a%20in%20Astrocyte-derived%20Extracellular%20Vesicles%20Suppresses%20Brain%20Ischemia%20Reperfusion%20Injury%20via%20TP53INP1%20and%20the%20NF-BNLRP3%20Axis&amp;publication_year=2022&amp;author=X.%20Liu&amp;author=X.%20Lv&amp;author=Z.%20Liu&amp;author=M.%20Zhang&amp;author=Y.%20Leng\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref190\"><span class=\"anchor-text\">Google Acad\u00e9mico<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib192\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib192\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[192]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">YB Liang, PP Song, YH Zhu, JM Xu, PZ Zhu, RR Liu, YS Zhang<\/div>\n<div id=\"ref-id-sbref191\" class=\"title text-m\">LP17 dirigido a TREM-1 aten\u00faa la lesi\u00f3n neuronal inducida por isquemia cerebral al inhibir el estr\u00e9s oxidativo y la piroptosis<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Bioqu\u00edmica Biof\u00edsica. 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Biochem, 75 (4) (2019), p\u00e1gs. 531-547,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1007\/s13105-019-00702-7\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1007\/s13105-019-00702-7<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Ver art\u00edculo<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85071480099&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref202\"><span class=\"anchor-text\">Ver en Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Gastrodin%20ameliorates%20microvascular%20reperfusion%20injury-induced%20pyroptosis%20by%20regulating%20the%20NLRP3caspase-1%20pathway&amp;publication_year=2019&amp;author=W.%20Sun&amp;author=H.%20Lu&amp;author=L.%20Lyu&amp;author=P.%20Yang&amp;author=Z.%20Lin&amp;author=L.%20Li&amp;author=L.%20Sun&amp;author=D.%20Lu\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref202\"><span class=\"anchor-text\">Google Acad\u00e9mico<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib204\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib204\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[204]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">HS Zhang, B. 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Tradici\u00f3n. Ment\u00f3n. Medicina. 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Tradici\u00f3n. Ment\u00f3n. Medicina. 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Rep., 57 (1) (2005), p\u00e1gs. 14-22<\/div>\n<div class=\"comment\">PMID: 15849373<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-18044377751&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref254\"><span class=\"anchor-text\">Ver en Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=L-arginine%20and%20cardiovascular%20system&amp;publication_year=2005&amp;author=D.%20Cylwik&amp;author=A.%20Mogielnicki&amp;author=W.%20Buczko\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref254\"><span class=\"anchor-text\">Google Acad\u00e9mico<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib256\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib256\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[256]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">D. Cylwik, A. Mogielnicki, K. Kramkowski, J. Stokowski, W. Buczko<\/div>\n<div id=\"ref-id-sbref255\" class=\"title text-m\">Efecto antitromb\u00f3tico de\u00a0<span class=\"small-caps\">l<\/span>-arginina en ratas hipertensas<\/div>\n<\/div>\n<div class=\"host u-font-sans\">J. Physiol. 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Inflamm., 2020 (2020), Art\u00edculo 3201635,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1155\/2020\/3201635\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1155\/2020\/3201635<\/span><\/a><\/div>\n<div class=\"comment\">PMID: 32454788; PMCID: PMC7238342.<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Ver art\u00edculo<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85085510204&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref256\"><span class=\"anchor-text\">Ver en Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Intravenous%20Arginine%20Administration%20Downregulates%20NLRP3%20inflammasome%20activity%20and%20attenuates%20acute%20kidney%20injury%20in%20mice%20with%20polymicrobial%20sepsis&amp;publication_year=2020&amp;author=S.A.%20Tanuseputero&amp;author=M.T.%20Lin&amp;author=S.L.%20Yeh&amp;author=C.L.%20Yeh\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref256\"><span class=\"anchor-text\">Google Acad\u00e9mico<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<\/ol>\n<\/section>\n<\/section>\n<div id=\"section-cited-by\">\n<section class=\"ListArticles preview\" aria-label=\"Citado por\">\n<div class=\"PageDivider\"><\/div>\n<header id=\"citing-articles-header\">\n<h2 class=\"u-h4 u-margin-l-ver u-font-serif\">Citado por (7)<\/h2>\n<\/header>\n<div aria-describedby=\"citing-articles-header\">\n<div class=\"citing-articles u-margin-l-bottom\">\n<ul>\n<li class=\"ListArticleItem u-margin-l-bottom\">\n<div class=\"sub-heading u-margin-xs-bottom\">\n<p id=\"citing-articles-article-0-title\" class=\"u-font-serif\"><a class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874123009492\"><span class=\"anchor-text\">El extracto de Bombyx batryticatus activa el factor de coagulaci\u00f3n \u216b para promover la angiog\u00e9nesis en ratas con lesi\u00f3n por isquemia\/reperfusi\u00f3n cerebral<\/span><\/a><\/p>\n<div class=\"text-s\">2024, Revista de Etnofarmacolog\u00eda<\/div>\n<\/div>\n<div class=\"buttons text-s\">\n<p>&nbsp;<\/p>\n<\/div>\n<\/li>\n<li class=\"ListArticleItem u-margin-l-bottom\">\n<div class=\"sub-heading u-margin-xs-bottom\">\n<p id=\"citing-articles-article-1-title\" class=\"u-font-serif\"><a class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874123008589\"><span class=\"anchor-text\">Efectos neuroprotectores de la decocci\u00f3n de Jie-du-huo-xue sobre la piroptosis de la microgl\u00eda despu\u00e9s de la isquemia cerebral y la reperfusi\u00f3n. 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u-margin-l-bottom\">\n<div class=\"sub-heading u-margin-xs-bottom\">\n<p id=\"citing-articles-article-3-title\" class=\"u-font-serif\"><a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1002\/ptr.7994\" target=\"_blank\" rel=\"noopener\"><span class=\"anchor-text\">Avances de la fitoterapia en el accidente cerebrovascular isqu\u00e9mico dirigidos a la se\u00f1alizaci\u00f3n PI3K\/Akt<\/span><\/a><\/p>\n<div class=\"text-s\">2023, Investigaci\u00f3n en fitoterapia<\/div>\n<\/div>\n<div class=\"buttons text-s\"><\/div>\n<\/li>\n<\/ul>\n<\/div>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889\">Fuente<\/a><\/p>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>This suggests that breviscapine may significantly improve the cognitive function of CCI rats and reduce the pathological damage of ischemic neurons, and its mechanism may be related to the inhibition of NLRP3 inflammasome activation and pyroptosis pathway in brain tissue [211].<\/p>","protected":false},"author":1,"featured_media":5371,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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