{"id":5171,"date":"2024-01-16T11:01:40","date_gmt":"2024-01-16T11:01:40","guid":{"rendered":"https:\/\/farlong.com\/?p=5171"},"modified":"2024-01-27T10:30:11","modified_gmt":"2024-01-27T10:30:11","slug":"research-progress-on-pyroptosis-mediated-immune-inflammatory-response-in-ischemic-stroke-and-the-role-of-natural-plant-components-as-regulator-of-pyroptosis-a-review","status":"publish","type":"post","link":"https:\/\/directcm.com\/fr\/research-progress-on-pyroptosis-mediated-immune-inflammatory-response-in-ischemic-stroke-and-the-role-of-natural-plant-components-as-regulator-of-pyroptosis-a-review\/","title":{"rendered":"Progr\u00e8s de la recherche sur la r\u00e9ponse immuno-inflammatoire m\u00e9di\u00e9e par la pyroptose dans les accidents vasculaires c\u00e9r\u00e9braux isch\u00e9miques et le r\u00f4le des composants naturels des plantes en tant que r\u00e9gulateurs de la pyroptose\u00a0: une revue"},"content":{"rendered":"<div id=\"ab0015\" class=\"abstract author-highlights\">\n<h2 class=\"section-title u-h4 u-margin-l-top u-margin-xs-bottom\">Points forts<\/h2>\n<div id=\"abs0015\">\n<ul>\n<li id=\"p0005\">Cette revue a r\u00e9sum\u00e9 le dernier m\u00e9canisme mol\u00e9culaire de la pyroptose lors d&#039;un accident vasculaire c\u00e9r\u00e9bral isch\u00e9mique.<\/li>\n<li id=\"p0010\">Cette revue r\u00e9sume le r\u00f4le des composants naturels des plantes en tant que r\u00e9gulateurs de la pyroptose dans les accidents vasculaires c\u00e9r\u00e9braux isch\u00e9miques.<\/li>\n<li id=\"p0015\">La r\u00e9gulation de la pyroptose dans les accidents vasculaires c\u00e9r\u00e9braux isch\u00e9miques est propos\u00e9e comme strat\u00e9gie th\u00e9rapeutique potentielle.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div id=\"ab0010\" class=\"abstract author\"><\/p>\n<h2><\/h2>\n<h2 class=\"section-title u-h4 u-margin-l-top u-margin-xs-bottom\">Abstrait<\/h2>\n<div id=\"abs0010\">\n<p id=\"sp0030\"><a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019AVC isch\u00e9mique gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/brain-ischemia\">AVC isch\u00e9mique<\/a>\u00a0(IS) est l\u2019une des principales causes de d\u00e9c\u00e8s et d\u2019invalidit\u00e9. Sa pathogen\u00e8se n&#039;est pas compl\u00e8tement claire et la cascade inflammatoire en est l&#039;une des principales.\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les processus pathologiques gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathological-process\">processus pathologiques<\/a>. La pratique clinique actuelle de l&#039;IS consiste \u00e0 restaurer le\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019approvisionnement en sang gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascularity\">approvisionnement en sang<\/a>\u00a0\u00e0 la zone isch\u00e9mique apr\u00e8s l&#039;EI d\u00e8s que possible via\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la th\u00e9rapie thrombolytique gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/fibrinolytic-therapy\">th\u00e9rapie thrombolytique<\/a>\u00a0pour prot\u00e9ger la vitalit\u00e9 et la fonction des neurones. Cependant, la reperfusion sanguine acc\u00e9l\u00e8re encore les l\u00e9sions isch\u00e9miques et provoque des l\u00e9sions d&#039;isch\u00e9mie-reperfusion. Le processus pathologique des l\u00e9sions d\u2019isch\u00e9mie-reperfusion c\u00e9r\u00e9brale implique de multiples m\u00e9canismes et le m\u00e9canisme exact n\u2019a pas \u00e9t\u00e9 enti\u00e8rement \u00e9lucid\u00e9.\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la pyroptose gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyroptosis\">Pyroptose<\/a>, une forme r\u00e9cemment d\u00e9couverte de maladie inflammatoire\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la mort cellulaire programm\u00e9e gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/programmed-cell-death\">la mort cellulaire programm\u00e9e<\/a>, joue un r\u00f4le important dans l\u2019initiation et la progression de l\u2019inflammation. Il s&#039;agit d&#039;une mort programm\u00e9e pro-inflammatoire m\u00e9di\u00e9e par\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la caspase gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/caspase\">caspase<\/a>\u00a0La caspase-1\/4\/5\/11, qui peut entra\u00eener un gonflement et une rupture des cellules, lib\u00e8re les facteurs inflammatoires IL-1\u03b2 et IL-18 et induit une cascade inflammatoire. Des \u00e9tudes r\u00e9centes ont montr\u00e9 que la pyroptose et sa r\u00e9ponse inflammatoire m\u00e9di\u00e9e sont des facteurs importants dans l&#039;aggravation des l\u00e9sions c\u00e9r\u00e9brales isch\u00e9miques, et que l&#039;inhibition de la pyroptose peut att\u00e9nuer les l\u00e9sions c\u00e9r\u00e9brales isch\u00e9miques. De plus, des \u00e9tudes ont montr\u00e9 que les composants naturels des plantes peuvent avoir un effet r\u00e9gulateur sur la pyroptose. Par cons\u00e9quent, cette revue r\u00e9sume non seulement le m\u00e9canisme mol\u00e9culaire de la pyroptose et son r\u00f4le dans l&#039;accident vasculaire c\u00e9r\u00e9bral isch\u00e9mique, mais \u00e9galement le r\u00f4le des composants naturels des plantes en tant que r\u00e9gulateurs de la pyroptose, afin de fournir des informations de r\u00e9f\u00e9rence sur la pyroptose pour le\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le traitement gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/therapeutic-procedure\">traitement<\/a>\u00a0de l&#039;EI dans le futur.<\/p>\n<div class=\"Keywords u-font-serif text-s\">\n<div id=\"keys0005\" class=\"keywords-section\">\n<h2 class=\"section-title u-h4 u-margin-l-top u-margin-xs-bottom\">Mots cl\u00e9s<\/h2>\n<div id=\"key0005\" class=\"keyword\">Pyroptose\u00a0; AVC isch\u00e9mique; Caspases; Composants v\u00e9g\u00e9taux naturels\u00a0; Inflammasome<\/div>\n<\/div>\n<\/div>\n<div id=\"body\" class=\"Body u-font-serif text-s\">\n<div>\n<section id=\"sec0005\">\n<h2 id=\"sect0025\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">1. Introduction<\/h2>\n<p id=\"p0025\">Avec le vieillissement de la population mondiale, l&#039;incidence de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les maladies c\u00e9r\u00e9brovasculaires gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebrovascular-disease\">maladie c\u00e9r\u00e9brovasculaire<\/a>\u00a0(comme les accidents vasculaires c\u00e9r\u00e9braux) est devenu le deuxi\u00e8me plus grand au monde et la menace pour les \u00eatres humains augmente\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib1\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib1\"><span class=\"anchor-text\">[1]<\/span><\/a>. L&#039;AVC comprend\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019AVC isch\u00e9mique gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/brain-ischemia\">AVC isch\u00e9mique<\/a>\u00a0(Est et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019AVC h\u00e9morragique gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebral-hemorrhage\">AVC h\u00e9morragique<\/a>, et jusqu&#039;\u00e0 871\u00a0TP3T des accidents vasculaires c\u00e9r\u00e9braux sont isch\u00e9miques\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib2\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib2\"><span class=\"anchor-text\">[2]<\/span><\/a>. L\u2019EI est une urgence clinique courante et son incidence augmente d\u2019ann\u00e9e en ann\u00e9e. La pratique clinique actuelle de l&#039;IS consiste \u00e0 restaurer le\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019approvisionnement en sang gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascularity\">approvisionnement en sang<\/a>\u00a0\u00e0 la zone isch\u00e9mique apr\u00e8s l&#039;EI d\u00e8s que possible via\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la th\u00e9rapie thrombolytique gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/fibrinolytic-therapy\">th\u00e9rapie thrombolytique<\/a>\u00a0pour prot\u00e9ger la vitalit\u00e9 et le fonctionnement des neurones\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib3\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib3\"><span class=\"anchor-text\">[3]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib4\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib4\"><span class=\"anchor-text\">[4]<\/span><\/a>. Cependant, les l\u00e9sions d&#039;isch\u00e9mie-reperfusion (IRI) apr\u00e8s r\u00e9tablissement du flux sanguin provoquent souvent des dommages plus graves \u00e0\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les tissus c\u00e9r\u00e9braux gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-tissue\">tissu c\u00e9r\u00e9bral<\/a>\u00a0et les cellules nerveuses, ce qui devient en outre un facteur important conduisant \u00e0 un mauvais pronostic et \u00e0 un dysfonctionnement des patients\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib5\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib5\"><span class=\"anchor-text\">[5]<\/span><\/a>. L&#039;enqu\u00eate \u00e9pid\u00e9miologique mondiale a analys\u00e9 les donn\u00e9es de 1990 \u00e0 2019 dans 204 pays et r\u00e9gions du monde. Leur rapport indique que les accidents vasculaires c\u00e9r\u00e9braux restent la deuxi\u00e8me cause de d\u00e9c\u00e8s (11,61 TP3T du total des d\u00e9c\u00e8s) et la troisi\u00e8me cause de d\u00e9c\u00e8s et d&#039;invalidit\u00e9 [5,71 TP3T du total\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les ann\u00e9es de vie ajust\u00e9es sur le handicap gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect.\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/disability-adjusted-life-years\">Ann\u00e9es de vie corrig\u00e9es de l&#039;incapacit\u00e9<\/a>\u00a0(DALY)], qui vient juste derri\u00e8re\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les maladies n\u00e9onatales gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/newborn-disease\">maladie n\u00e9onatale<\/a>\u00a0(7,31 DALY TP3T) et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les cardiopathies isch\u00e9miques gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemic-heart-disease\">la cardiopathie isch\u00e9mique<\/a>\u00a0(7,21 DALY TP3T), et le nombre de patients victimes d\u2019un AVC continue d\u2019augmenter\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib6\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib6\"><span class=\"anchor-text\">[6]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib7\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib7\"><span class=\"anchor-text\">[7]<\/span><\/a>, notamment en Chine. La Chine est devenue le pays o\u00f9 le risque d&#039;accident vasculaire c\u00e9r\u00e9bral est le plus \u00e9lev\u00e9 au monde, avec un risque d&#039;accident vasculaire c\u00e9r\u00e9bral parmi les r\u00e9sidents atteignant 39,31 TP3T, et le risque d&#039;accident vasculaire c\u00e9r\u00e9bral chez les hommes chinois est \u00e9galement le plus \u00e9lev\u00e9 parmi les hommes dans le monde, d\u00e9passant 411 TP3T ; L&#039;EI est pass\u00e9 de la troisi\u00e8me cause de d\u00e9c\u00e8s (en 1990) \u00e0 la premi\u00e8re (en 2017) parmi les r\u00e9sidents chinois.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib8\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib8\"><span class=\"anchor-text\">[8]<\/span><\/a>. Les \u00e9tudes actuelles sugg\u00e8rent que les m\u00e9canismes pathologiques de l&#039;IRI c\u00e9r\u00e9bral (CIRI) sont principalement\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le stress oxydatif gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/oxidative-stress\">stress oxydatif<\/a>\u00a0blessure,\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les l\u00e9sions inflammatoires gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammatory-injury\">blessure inflammatoire<\/a>, l\u00e9sions mitochondriales, autophagie et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019apoptose gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/programmed-cell-death\">apoptose<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib9\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib9\"><span class=\"anchor-text\">[9]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib10\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib10\"><span class=\"anchor-text\">[10]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib11\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib11\"><span class=\"anchor-text\">[11]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib12\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib12\"><span class=\"anchor-text\">[12]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib13\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib13\"><span class=\"anchor-text\">[13]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib14\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib14\"><span class=\"anchor-text\">[14]<\/span><\/a>. Cependant, ceux-ci sont encore insuffisants pour expliquer le m\u00e9canisme pathologique de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le CIRI gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunoreactive-insulin\">CIRI<\/a>. Par exemple, on pense que la mort neuronale apr\u00e8s CIRI est principalement caus\u00e9e par l&#039;apoptose, et que la protection des cellules neuronales est principalement anti-apoptose. Cependant, l\u2019apoptose n\u2019est pas directement li\u00e9e \u00e0 l\u2019inflammation.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib15\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib15\"><span class=\"anchor-text\">[15]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib16\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib16\"><span class=\"anchor-text\">[16]<\/span><\/a>, mais il existe une r\u00e9ponse inflammatoire importante dans le CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib16\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib16\"><span class=\"anchor-text\">[16]<\/span><\/a>. Par cons\u00e9quent, il est n\u00e9cessaire de clarifier davantage le m\u00e9canisme physiopathologique de l\u2019IS et d\u2019explorer davantage l\u2019\u00e9tiologie du CIRI.<\/p>\n<p id=\"p0030\"><a class=\"topic-link\" title=\"Apprenez-en davantage sur la pyroptose gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyroptosis\">Pyroptose<\/a>, aussi connu sous le nom\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019inflammation cellulaire gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammatory-cell\">cellule inflammatoire<\/a>\u00a0n\u00e9crose, est une mort cellulaire programm\u00e9e nouvellement d\u00e9couverte et confirm\u00e9e ces derni\u00e8res ann\u00e9es\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib17\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib17\"><span class=\"anchor-text\">[17]<\/span><\/a>. La pyroptose d\u00e9pend de l&#039;inflammation\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les caspases gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/caspase\">caspases<\/a>\u00a0(principalement caspase-1, 4, 5, 11) et s&#039;accompagne de la lib\u00e9ration d&#039;un grand nombre de facteurs pro-inflammatoires. Elle se manifeste par l&#039;expansion continue des cellules jusqu&#039;\u00e0 ce que la cellule\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les ruptures de membrane gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/membrane-rupture\">ruptures de membrane<\/a>, entra\u00eenant la lib\u00e9ration du contenu cellulaire et l&#039;activation d&#039;une forte r\u00e9ponse inflammatoire\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib17\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib17\"><span class=\"anchor-text\">[17]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib18\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib18\"><span class=\"anchor-text\">[18]<\/span><\/a>. Le\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les caract\u00e9ristiques morphologiques gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/morphological-trait\">caract\u00e9ristiques morphologiques<\/a>, l&#039;apparition et le m\u00e9canisme de r\u00e9gulation de la pyroptose sont diff\u00e9rents des autres m\u00e9thodes de mort cellulaire telles que l&#039;apoptose et la n\u00e9crose\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib18\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib18\"><span class=\"anchor-text\">[18]<\/span><\/a>. La pyroptose est largement impliqu\u00e9e dans l&#039;apparition et le d\u00e9veloppement de diverses maladies telles que les maladies infectieuses, les maladies li\u00e9es au syst\u00e8me nerveux, les maladies ath\u00e9roscl\u00e9reuses et les tumeurs malignes.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib19\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib19\"><span class=\"anchor-text\">[19]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib20\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib20\"><span class=\"anchor-text\">[20]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib21\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib21\"><span class=\"anchor-text\">[21]<\/span><\/a>. Les derni\u00e8res \u00e9tudes montrent que la pyroptose et sa r\u00e9ponse inflammatoire m\u00e9di\u00e9e sont impliqu\u00e9es dans la\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le processus pathologique gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathological-process\">processus pathologique<\/a>\u00a0de l&#039;IS, et pr\u00e9venir l&#039;activation de la pyroptose est b\u00e9n\u00e9fique pour inhiber la cascade inflammatoire et r\u00e9duire les l\u00e9sions c\u00e9r\u00e9brales isch\u00e9miques\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib22\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib22\"><span class=\"anchor-text\">[22]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib23\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib23\"><span class=\"anchor-text\">[23]<\/span><\/a>. Sur cette base, l\u2019\u00e9tude de la pyroptose est cruciale pour le\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le traitement gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/therapeutic-procedure\">traitement<\/a>\u00a0du SI ; la r\u00e9gulation de la pyroptose peut r\u00e9duire le taux de mortalit\u00e9 de l&#039;EI, am\u00e9liorer le taux de survie des neurones et am\u00e9liorer les sympt\u00f4mes des patients atteints de l&#039;EI. Actuellement,\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les m\u00e9dicaments gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chemotherapeutic-agent\">drogues<\/a>\u00a0qui exerce\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les neuroprotecteurs gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroprotective-agent\">neuroprotecteur<\/a>\u00a0des effets en r\u00e9gulant la voie de la pyroptose sont en cours de d\u00e9veloppement. En particulier, il existe de nombreuses \u00e9tudes sur les composants v\u00e9g\u00e9taux naturels r\u00e9gulant la pyroptose des unit\u00e9s neuronales vasculaires dans l&#039;IS. Nos \u00e9tudes pr\u00e9c\u00e9dentes ont \u00e9galement montr\u00e9 que\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les saponines gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/saponin\">saponines<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib24\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib24\"><span class=\"anchor-text\">[24]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib25\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib25\"><span class=\"anchor-text\">[25]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib26\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib26\"><span class=\"anchor-text\">[26]<\/span><\/a>\u00a0et compos\u00e9s multicomposants\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib27\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib27\"><span class=\"anchor-text\">[27]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib28\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib28\"><span class=\"anchor-text\">[28]<\/span><\/a>\u00a0peut r\u00e9guler le\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les processus biologiques gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/biological-phenomena-and-functions-concerning-the-entire-organism\">processus biologique<\/a>\u00a0de pyroptose dans IS. Par cons\u00e9quent, cette revue r\u00e9sume non seulement le m\u00e9canisme mol\u00e9culaire de la pyroptose et son r\u00f4le dans l&#039;accident vasculaire c\u00e9r\u00e9bral isch\u00e9mique, mais \u00e9galement le r\u00f4le des composants v\u00e9g\u00e9taux naturels en tant que r\u00e9gulateurs de la pyroptose afin de fournir des compos\u00e9s principaux ou des composants v\u00e9g\u00e9taux naturels pour le d\u00e9veloppement futur de m\u00e9dicaments li\u00e9s \u00e0 la pyroptose.<\/p>\n<\/section>\n<section id=\"sec0010\">\n<h2 id=\"sect0030\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">2. Pyroptose<\/h2>\n<section id=\"sec0015\">\n<h3 id=\"sect0035\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.1. Les caract\u00e9ristiques de la pyroptose<\/h3>\n<div>\n<p id=\"p0035\"><a class=\"topic-link\" title=\"Apprenez-en davantage sur la pyroptose gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyroptosis\">Pyroptose<\/a>\u00a0est une forme de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la mort cellulaire programm\u00e9e gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/programmed-cell-death\">la mort cellulaire programm\u00e9e<\/a>\u00a0d\u00e9pendant des pro-inflammatoires\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les caspases gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/caspase\">caspases<\/a>, qui se caract\u00e9rise par la formation de pores transmembranaires, le gonflement et la rupture des membranes cellulaires et la lib\u00e9ration de contenus pro-inflammatoires\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib29\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib29\"><span class=\"anchor-text\">[29]<\/span><\/a>. Dans le processus d&#039;apoptose, les cellules ont une fragmentation nucl\u00e9aire et une int\u00e9grit\u00e9 de la membrane cellulaire, ce qui ne provoque pas de r\u00e9ponse inflammatoire dans les tissus environnants, tandis que les cellules en cours de pyroptose ont une morphologie nucl\u00e9aire compl\u00e8te et une int\u00e9grit\u00e9 cellulaire.\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la rupture de la membrane gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/membrane-rupture\">rupture de membrane<\/a>, qui provoque une inflammation p\u00e9riph\u00e9rique\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib30\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib30\"><span class=\"anchor-text\">[30]<\/span><\/a>. Lorsque la pyroptose se produit, la membrane cellulaire se rompt progressivement pour former des pores de 1 \u00e0 2 nm, puis le contenu cellulaire tel que les facteurs inflammatoires intracellulaires et d&#039;autres substances est lib\u00e9r\u00e9 \u00e0 l&#039;ext\u00e9rieur de la membrane cellulaire. Colorants p\u00e9n\u00e9trant la membrane tels que\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le bromure d\u2019\u00e9thidium gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ethidium-bromide\">le bromure d&#039;\u00e9thidium<\/a>\u00a0peut \u00eatre utilis\u00e9 pour observer si les cellules subissent une pyroptose\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib31\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib31\"><span class=\"anchor-text\">[31]<\/span><\/a>. De plus, la survenue de n\u00e9crose d\u00e9pend de la s\u00e9rie mixte de prot\u00e9ines kinase-like\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les prot\u00e9ines de domaine gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/protein-domain\">prot\u00e9ine de domaine<\/a>\u00a0(MLKL), qui est s\u00e9lective pour les ions entrant dans la cellule, et la chromatine nucl\u00e9aire est floculante ou agglutin\u00e9e sur les bords. La pyroptose d\u00e9pend de la prot\u00e9ine porog\u00e8ne GSDMD, une prot\u00e9ine non s\u00e9lective qui provoque des\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le pycnosis gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyknosis\">pycnose<\/a>\u00a0et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la fragmentation de l\u2019ADN gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/dna-fragmentation\">Fragmentation de l&#039;ADN<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib32\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib32\"><span class=\"anchor-text\">[32]<\/span><\/a>. Il existe des similitudes et des diff\u00e9rences entre la pyroptose, l&#039;apoptose, la n\u00e9croptose et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la ferroptose gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ferroptosis\">ferroptose<\/a>, comme la cause, les changements de cellules, etc. Les d\u00e9tails sont affich\u00e9s dans\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#tbl0005\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"tbl0005\"><span class=\"anchor-text\">Tableau 1<\/span><\/a>.<\/p>\n<div id=\"tbl0005\" class=\"tables colsep-0 rowsep-0 frame-topbot\">\n<p id=\"sp0020\"><span class=\"label\">Tableau 1<\/span>. Similitudes et diff\u00e9rences entre la pyroptose, l&#039;apoptose et la n\u00e9croptose.<\/p>\n<div class=\"groups\">\n<table>\n<thead>\n<tr class=\"rowsep-1\">\n<th scope=\"col\">Caract\u00e9ristiques<\/th>\n<th scope=\"col\">Composants signatures<\/th>\n<th scope=\"col\">Changements dans les cellules<\/th>\n<th scope=\"col\">Cause g\u00e9n\u00e9rale<\/th>\n<th scope=\"col\">Inhibiteurs<\/th>\n<th scope=\"col\">R\u00e9f\u00e9rence<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<th scope=\"row\">Pyroptose<\/th>\n<td>Pyroptosome, inflammasome<\/td>\n<td>Formation de pores, gonflement cellulaire, rupture de la membrane plasmique, condensation de la chromatine, fragmentation de l&#039;ADN mais int\u00e9grit\u00e9 nucl\u00e9aire, etc.<\/td>\n<td>HUMIDE, PAMP, infection<\/td>\n<td>Inhibiteurs de la GSDMD<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib19\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib19\"><span class=\"anchor-text\">[19]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib33\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib33\"><span class=\"anchor-text\">[33]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib34\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib34\"><span class=\"anchor-text\">[34]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib35\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib35\"><span class=\"anchor-text\">[35]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib36\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib36\"><span class=\"anchor-text\">[36]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Apoptose<\/th>\n<td>Apoptosome<\/td>\n<td>La cellule r\u00e9tr\u00e9cit avec une membrane intacte, des saignements de la membrane plasmique, une condensation de la chromatine, une fragmentation de l&#039;ADN, etc.<\/td>\n<td>R\u00e9gulation g\u00e9n\u00e9tique des \u00e9tats physiologiques<\/td>\n<td>Famille des caspases r\u00e9gulatrices, famille Bcl-2, p53, etc.<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib37\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib37\"><span class=\"anchor-text\">[37]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib38\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib38\"><span class=\"anchor-text\">[38]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib39\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib39\"><span class=\"anchor-text\">[39]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">N\u00e9croptose<\/th>\n<td>N\u00e9crosome<\/td>\n<td>Gonflement cellulaire, rupture de la membrane plasmique, gonflement des organites, condensation de la chromatine, etc.<\/td>\n<td>Blessure grave<\/td>\n<td>Nec-1, NSA, etc.<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib33\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib33\"><span class=\"anchor-text\">[33]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib40\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib40\"><span class=\"anchor-text\">[40]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib41\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib41\"><span class=\"anchor-text\">[41]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib42\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib42\"><span class=\"anchor-text\">[42]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib43\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib43\"><span class=\"anchor-text\">[43]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Ferroptose<\/th>\n<td>NRF2, GPX4, ACSL4, etc.<\/td>\n<td>Se produit principalement dans les mitochondries, avec des cr\u00eates mitochondriales r\u00e9duites, des membranes condens\u00e9es et des membranes externes rompues.<\/td>\n<td>Fe2 + surcharge et ROS<\/td>\n<td>GSH, d\u00e9f\u00e9roxamine, liproxstatine-1, ferrostatine-1, etc.<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib44\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib44\"><span class=\"anchor-text\">[44]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib45\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib45\"><span class=\"anchor-text\">[45]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib46\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib46\"><span class=\"anchor-text\">[46]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib47\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib47\"><span class=\"anchor-text\">[47]<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section id=\"sec0020\">\n<h3 id=\"sect0040\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.2. Le m\u00e9canisme mol\u00e9culaire de la pyroptose<\/h3>\n<p id=\"p0040\">La formation de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019inflammasome gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammasome\">inflammasome<\/a>\u00a0est la substance cl\u00e9 de la pyroptose apr\u00e8s une blessure. Lorsqu&#039;il est bless\u00e9, le corps peut activer le signal de mod\u00e8le li\u00e9 aux mod\u00e8les mol\u00e9culaires associ\u00e9s aux agents pathog\u00e8nes (PAMP) et aux mod\u00e8les mol\u00e9culaires associ\u00e9s aux dommages (DAMP).\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib48\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib48\"><span class=\"anchor-text\">[48]<\/span><\/a>. Lorsque le signal est stimul\u00e9, le r\u00e9seau intracellulaire\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la prot\u00e9ine promotrice gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/promoter-protein\">prot\u00e9ine promotrice<\/a>\u00a0r\u00e9cepteur de type domaine d&#039;oligom\u00e9risation se liant aux nucl\u00e9otides\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le domaine de la pyrine gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyrin-domain\">domaine de la pyrine<\/a>\u00a0contenant 3 (NLRP3) peut recruter une grande quantit\u00e9 de procaspase-1 en utilisant la mol\u00e9cule adaptatrice de l&#039;inflammasome ASC par oligom\u00e9risation\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib49\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib49\"><span class=\"anchor-text\">[49]<\/span><\/a>, la formation de prot\u00e9ines agr\u00e9g\u00e9es d&#039;inflammasome. La procaspase-1 est le pr\u00e9curseur de la caspase-1 et, normalement, la procaspase-1 existe dans l&#039;organisme sous forme de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le zymog\u00e8ne gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/enzyme-precursor\">zymog\u00e8ne<\/a>. Lorsque des signaux de stimulation sont d\u00e9livr\u00e9s \u00e0 la procaspase-1, elle g\u00e9n\u00e8re des sous-unit\u00e9s P20 et P10 par autohydrolyse. Cette sous-unit\u00e9 forme d&#039;abord un\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019h\u00e9t\u00e9rodim\u00e8re gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/heterodimer\">h\u00e9t\u00e9rodim\u00e8re<\/a>\u00a0qui ne peut pas fonctionner, puis s&#039;agr\u00e8ge pour former un\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le t\u00e9tram\u00e8re gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tetramer\">t\u00e9tram\u00e8re<\/a>\u00a0qui favorise l&#039;activit\u00e9 de la caspase-1, conduisant \u00e0 l&#039;activation de la caspase-1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib50\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib50\"><span class=\"anchor-text\">[50]<\/span><\/a>. Lorsque la caspase-1 est activ\u00e9e, la caspase-1 active est responsable de la formation de pores de la membrane cellulaire et de la lyse rapide de la membrane cellulaire pour former une r\u00e9ponse inflammatoire. Pendant ce temps, la caspase-1 peut \u00e9galement induire les pr\u00e9curseurs de l\u2019IL-1\u03b2 et de l\u2019IL-18, la pro-IL-1\u03b2 et la pro-IL-18, pour acc\u00e9l\u00e9rer le processus de maturation. Les IL-1\u03b2 et IL-18 matures sont lib\u00e9r\u00e9es de mani\u00e8re extracellulaire, recrutant ainsi davantage d&#039;inflammasomes. Une fois l\u2019inflammasome regroup\u00e9, la r\u00e9ponse inflammatoire est encore aggrav\u00e9e et les l\u00e9sions tissulaires sont aggrav\u00e9es. Une fois l\u2019IL-1\u03b2 lib\u00e9r\u00e9e des cellules, les facteurs inflammatoires se propagent aux tissus adjacents avec le flux lymphatique, aggravant encore la r\u00e9ponse inflammatoire. La s\u00e9cr\u00e9tion d&#039;une grande quantit\u00e9 d&#039;IL-18 provoque des r\u00e9ponses immunitaires Th1 et Th2 et stimule la r\u00e9ponse immunitaire \u00e0 jouer un r\u00f4le\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib51\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib51\"><span class=\"anchor-text\">[51]<\/span><\/a>.<\/p>\n<section id=\"sec0025\">\n<h4 id=\"sect0045\" class=\"u-margin-m-top u-margin-xs-bottom\">2.2.1. Voie canonique de la pyroptose<\/h4>\n<p id=\"p0045\">La caspase-1 est une prot\u00e9ine cl\u00e9 de la voie pyroptotique canonique, dans laquelle l&#039;inflammasome joue un r\u00f4le important dans l&#039;activation de la caspase-1.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib52\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib52\"><span class=\"anchor-text\">[52]<\/span><\/a>. L&#039;inflammasome est un \u00e9l\u00e9ment important du syst\u00e8me immunitaire inn\u00e9 et est un complexe multiprot\u00e9ique compos\u00e9 de prot\u00e9ines capteurs, d&#039;ASC et de pro-Caspase-1. Il existe dans le cytoplasme des\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les cellules immunitaires gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunocompetent-cell\">cellules immunitaires<\/a>\u00a0et peut d\u00e9tecter les signaux de stimulation extracellulaires\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib53\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib53\"><span class=\"anchor-text\">[53]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib54\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib54\"><span class=\"anchor-text\">[54]<\/span><\/a>. Les inflammasomes sont divis\u00e9s en inflammasomes contenant des r\u00e9cepteurs de type domaine d&#039;oligom\u00e9risation (NLR) se liant aux nucl\u00e9otides, r\u00e9sum\u00e9 dans\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le m\u00e9lanome gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nodular-melanoma\">m\u00e9lanome<\/a>\u00a0Inflammasomes 2 (AIM2) et inflammasomes NLRC4\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib55\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib55\"><span class=\"anchor-text\">[55]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib56\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib56\"><span class=\"anchor-text\">[56]<\/span><\/a>. Le r\u00e9cepteur Purinergic 2 \u00d7 7 (P2X7) est un r\u00e9cepteur de canal ionique transmembranaire ATP-d\u00e9pendant exprim\u00e9 en\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les microglies gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microglia\">microglie<\/a>\u00a0et constitue un facteur cl\u00e9 dans l&#039;activation de l&#039;inflammasome. Des \u00e9tudes ont montr\u00e9 que l&#039;ATP extracellulaire peut r\u00e9guler l&#039;efflux de K+ en activant le\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le r\u00e9cepteur P2X7 gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/purinergic-p2x7-receptor\">R\u00e9cepteur P2X7<\/a>, induisant l&#039;activation de la famille NLR, contenant le domaine pyrine 3 (NLRP3)\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib57\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib57\"><span class=\"anchor-text\">[57]<\/span><\/a>. L&#039;inflammasome NLRP3 est actuellement le plus \u00e9tudi\u00e9. L&#039;activation de l&#039;inflammasome NLRP3 n\u00e9cessite une r\u00e9ponse en deux \u00e9tapes\u00a0: initiation de la r\u00e9ponse, facteur nucl\u00e9aire microbien ou endog\u00e8ne-\u03baB (NF-\u03baB) dans le noyau et r\u00e9gulation positive de l&#039;expression de NLRP3 et de la pro-IL-1\u03b2.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib58\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib58\"><span class=\"anchor-text\">[58]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib59\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib59\"><span class=\"anchor-text\">[59]<\/span><\/a>. Lorsque les cellules immunitaires sont stimul\u00e9es par les DAMP, la prot\u00e9ine capteur recrute la pro-Caspase-1 via l&#039;ASC, qui est ensuite activ\u00e9e par autohydrolyse. La caspase-1 mature transforme en aval la pro-IL-1\u03b2 et la pro-IL-18 inactives en IL-1\u03b2 et IL-18 actives\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib60\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib60\"><span class=\"anchor-text\">[60]<\/span><\/a>. Pendant ce temps, la caspase-1 clive la prot\u00e9ine GSDMD en aval en fragment GSDMD-N et fragment GSDMD-C avec une activit\u00e9 porog\u00e8ne. Le fragment GSDMD-N reconna\u00eet sp\u00e9cifiquement et se lie au\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les lipides membranaires gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/membrane-lipid\">lipides membranaires<\/a>\u00a0sur la face interne de la membrane cellulaire, provoquant des modifications de la pression osmotique intracellulaire et extracellulaire, qui \u00e0 leur tour entra\u00eenent un gonflement et une rupture cellulaire ainsi que la lib\u00e9ration de facteurs inflammatoires IL-1\u03b2 et IL-18, induisant une r\u00e9ponse inflammatoire et une pyroptose cellulaire\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib61\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib61\"><span class=\"anchor-text\">[61]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0030\">\n<h4 id=\"sect0050\" class=\"u-margin-m-top u-margin-xs-bottom\">2.2.2. Voie non canonique de la pyroptose<\/h4>\n<p id=\"p0050\">La famille des caspases est principalement divis\u00e9e en deux cat\u00e9gories\u00a0: celles li\u00e9es \u00e0 l&#039;apoptose et celles li\u00e9es \u00e0 l&#039;inflammation selon diff\u00e9rentes fonctions. Les caspases-3\/2\/10 interviennent principalement dans l&#039;apoptose, tandis que les caspases-1\/4\/5\/11 sont des m\u00e9diateurs cl\u00e9s de l&#039;inflammation et des r\u00e9ponses immunitaires inn\u00e9es.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib62\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib62\"><span class=\"anchor-text\">[62]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib63\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib63\"><span class=\"anchor-text\">[63]<\/span><\/a>. La voie pyroptotique non canonique d\u00e9pend de l&#039;activation de la Caspase-4\/5\/11, alors que l&#039;inflammasome n&#039;est pas essentiel \u00e0 la maturation de l&#039;IL-1\u03b2 et de l&#039;IL-18.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib64\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib64\"><span class=\"anchor-text\">[64]<\/span><\/a>. La voie non classique de la pyroptose est induite par\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les lipopolysaccharides gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/lipopolysaccharide\">lipopolysaccharide<\/a>\u00a0(LPS), un composant de la paroi cellulaire des bact\u00e9ries \u00e0 Gram n\u00e9gatif. Le LPS peut se lier directement \u00e0 la Caspase-4\/5 humaine et \u00e0 la Caspase-11 de souris. Ces caspases agissent \u00e0 la fois comme prot\u00e9ines capteurs et mol\u00e9cules effectrices du LPS. La Caspase-4\/5\/11 activ\u00e9e clive directement le GSDMD et induit la pyroptose\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib65\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib65\"><span class=\"anchor-text\">[65]<\/span><\/a>. De plus, des \u00e9tudes ont montr\u00e9 que la Caspase-11 peut activer les\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les jonctions lacunaires gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect.\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/gap-junction\">jonctions lacunaires<\/a>\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les prot\u00e9ines de canal dans les pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/channel-protein\">prot\u00e9ine de canal<\/a>\u00a0La pannexine-1 favorise l&#039;efflux de K+, et l&#039;efflux de K+ peut activer l&#039;inflammasome NLRP3, qui \u00e0 son tour active la Caspase-1 et favorise la maturation de l&#039;IL-1\u03b2 et de l&#039;IL-18.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib66\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib66\"><span class=\"anchor-text\">[66]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0035\">\n<h4 id=\"sect0055\" class=\"u-margin-m-top u-margin-xs-bottom\">2.2.3. La relation entre GSDMD et pyroptose<\/h4>\n<p id=\"p0055\">GSDMD (Gsdermin D) est une prot\u00e9ine compos\u00e9e de 484 fragments de r\u00e9sidus d&#039;acides amin\u00e9s et fait partie de la famille des prot\u00e9ines Gasdermin. Il y a principalement 5 membres dans cette famille, ce sont : DFNA5, DFNB59, GSDMA, GSDMB, GSDMCD. Les structures d&#039;acides amin\u00e9s de ces cinq prot\u00e9ines sont tr\u00e8s similaires et ces prot\u00e9ines contiennent deux domaines spatiaux, N-terminal et C-terminal.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib67\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib67\"><span class=\"anchor-text\">[67]<\/span><\/a>. La prot\u00e9ine GSDMD est un amino \u00e0 longue cha\u00eene\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les prot\u00e9ines acides gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/acid-protein\">prot\u00e9ine acide<\/a>, et la structure entre ses domaines N-terminal et C-terminal est relativement l\u00e2che. GSDMD est g\u00e9n\u00e9ralement cliv\u00e9 au niveau\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la s\u00e9quence d\u2019acides amin\u00e9s gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/peptide-sequence\">s\u00e9quence d&#039;acides amin\u00e9s<\/a>\u00a0275, exposant les domaines N-terminal et C-terminal. Dans\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les cellules de mammif\u00e8res gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mammalian-cell\">cellules de mammif\u00e8res<\/a>, la structure N-terminale simple du GSDMD peut r\u00e9guler la pyroptose cellulaire. Par cons\u00e9quent, GSDMD exprime souvent le domaine N-terminal mais ne peut pas exprimer toutes les prot\u00e9ines GSDMD.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib68\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib68\"><span class=\"anchor-text\">[68]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib69\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib69\"><span class=\"anchor-text\">[69]<\/span><\/a>. Cependant, des \u00e9tudes ont montr\u00e9 que lorsque le domaine N-terminal du GSDMD \u00e9tait introduit dans E. coli pour la culture, de puissants effets toxiques se produisaient. En revanche, le GSDMD intact et le domaine C-terminal du GSDMD ont pr\u00e9sent\u00e9 une toxicit\u00e9 relativement faible.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib70\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib70\"><span class=\"anchor-text\">[70]<\/span><\/a>. La structure N-terminale du GSDMD intracellulaire sera progressivement transf\u00e9r\u00e9e \u00e0 la membrane cellulaire avec l&#039;invasion de facteurs de dommage, et sur la membrane cellulaire, o\u00f9 elle se liera sp\u00e9cifiquement \u00e0 la phosphosarcosinase et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la phosphatidyls\u00e9rine gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/phosphatidylserine\">phosphatidyls\u00e9rine<\/a>\u00a0sur la membrane cellulaire pour produire des effets biologiques\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib71\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib71\"><span class=\"anchor-text\">[71]<\/span><\/a>. Utiliser des \u00e9quipements tels que la force atomique\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la microscopie \u00e9lectronique gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/electron-microscopy\">microscopie \u00e9lectronique<\/a>\u00a0et en microscopie cryo\u00e9lectronique, L. Sborigi a observ\u00e9 que la structure N-terminale du GSDMD peut \u00eatre combin\u00e9e avec des biofilms pour former un polym\u00e8re en forme d&#039;anneau creux sur le biofilm. Ce polym\u00e8re induit la formation de pores de biofilm, gr\u00e2ce auxquels le GSDMD induit une pyroptose dans les cellules en cas de dommages endog\u00e8nes. Lorsqu&#039;il est externe\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les agents pathog\u00e8nes gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathogen\">agents pathog\u00e8nes<\/a>\u00a0envahissent, ils sont capables de s&#039;adsorber \u00e0 la surface des cellules des agents pathog\u00e8nes et de prot\u00e9ger l&#039;organisme des substances nocives externes en lysant les cellules\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib72\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib72\"><span class=\"anchor-text\">[72]<\/span><\/a>. Le GSDMD est une substance qui se lie sp\u00e9cifiquement aux prot\u00e9ines caspase-1\/4\/5\/11 en aval de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la transduction du signal \u00e0 partir des pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/signal-transduction\">transduction du signal<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib73\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib73\"><span class=\"anchor-text\">[73]<\/span><\/a>. La caspase-1 favorise la lib\u00e9ration d&#039;IL-1\u03b2 et d&#039;IL-18 en aval hors de la membrane cellulaire gr\u00e2ce \u00e0 des r\u00e9ponses inflammatoires g\u00e9n\u00e9r\u00e9es par des complexes avec diverses prot\u00e9ines. La caspase-1 activ\u00e9e clive la prot\u00e9ine GSDMD, convertissant la GSDMD en peptides actifs. Les produits de d\u00e9composition du GSDMD se lient sp\u00e9cifiquement \u00e0 la membrane cellulaire et des composants tels que les mol\u00e9cules d&#039;eau extracellulaires p\u00e9n\u00e8trent dans la membrane cellulaire par les pores, provoquant le gonflement et la rupture des cellules.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib74\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib74\"><span class=\"anchor-text\">[74]<\/span><\/a>.<\/p>\n<\/section>\n<\/section>\n<section id=\"sec0040\">\n<h3 id=\"sect0060\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.3. Les ARN non codants participent \u00e0 l&#039;expression de g\u00e8nes pyroptotiques dans l&#039;IS<\/h3>\n<p id=\"p0060\">Ces derni\u00e8res ann\u00e9es, le m\u00e9canisme de r\u00e9gulation au niveau g\u00e9n\u00e9tique li\u00e9 \u00e0 l\u2019apparition de la pyroptose a \u00e9galement \u00e9t\u00e9 pleinement d\u00e9velopp\u00e9. Les \u00e9tudes modernes de biologie mol\u00e9culaire montrent que le 98% du g\u00e9nome n\u2019est pas impliqu\u00e9 dans le codage des prot\u00e9ines. Les ARN codants \u00e0 longue cha\u00eene (ARNlnc) sont des ARN sans fonction de codage des prot\u00e9ines, ainsi nomm\u00e9s car ils mesurent plus de 200 nucl\u00e9otides.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib75\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib75\"><span class=\"anchor-text\">[75]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib76\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib76\"><span class=\"anchor-text\">[76]<\/span><\/a>. Cependant, bien que\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur lncRNA gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/long-untranslated-rna\">ARNnc<\/a>\u00a0n&#039;a pas pour fonction de coder pour une prot\u00e9ine, c&#039;est le g\u00e8ne le plus exprim\u00e9 dans l&#039;organisme et le g\u00e8ne le plus conserv\u00e9 en transcription. Il participe \u00e0 d&#039;importants processus pathologiques et physiologiques de l&#039;organisme, notamment dans les maladies li\u00e9es aux l\u00e9sions de reperfusion, et joue un r\u00f4le important.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib77\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib77\"><span class=\"anchor-text\">[77]<\/span><\/a>. Des \u00e9tudes ont montr\u00e9 que dans la microglie, le niveau d\u2019expression du lncRNA-H19 est positivement corr\u00e9l\u00e9 \u00e0 la dur\u00e9e de la reperfusion\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib78\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib78\"><span class=\"anchor-text\">[78]<\/span><\/a>. La surexpression de LncRNA-H19 joue un r\u00f4le inflammatoire lorsqu&#039;elle favorise l&#039;expression de la mol\u00e9cule de signalisation en aval NLRP3\/6 et initie le GSDMD\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib79\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib79\"><span class=\"anchor-text\">[79]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib80\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib80\"><span class=\"anchor-text\">[80]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib81\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib81\"><span class=\"anchor-text\">[81]<\/span><\/a>. lncRNA-H19 est capable d&#039;activer les membres de la famille des prot\u00e9ines caspases\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib82\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib82\"><span class=\"anchor-text\">[82]<\/span><\/a>, conduisant \u00e0 un dysfonctionnement mitochondrial, participant \u00e0 l&#039;activation des inflammasomes et provoquant des l\u00e9sions neuronales\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib83\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib83\"><span class=\"anchor-text\">[83]<\/span><\/a>. En plus de r\u00e9guler la structure mol\u00e9culaire, lncRNA-H19 peut \u00e9galement recruter davantage de facteurs de transcription pour r\u00e9guler le processus de transcription de l&#039;ARNm.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib84\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib84\"><span class=\"anchor-text\">[84]<\/span><\/a>. De plus, lncRNA-H19 peut \u00e9galement favoriser la\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le transport nucl\u00e9aire gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nucleocytoplasmic-transport\">transport nucl\u00e9aire<\/a>\u00a0processus de facteurs de transcription, augmentant ainsi l&#039;expression sp\u00e9cifique d&#039;un plus grand nombre de g\u00e8nes cibles et g\u00e9n\u00e9rant un r\u00e9seau de cascade inflammatoire lorsque\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019isch\u00e9mie gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemia\">isch\u00e9mie<\/a>\u00a0se produit\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib84\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib84\"><span class=\"anchor-text\">[84]<\/span><\/a>. Par cons\u00e9quent, lncRNA-H19 constitue un signal de danger puissant lorsque\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le CIRI gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunoreactive-insulin\">CIRI<\/a>\u00a0se produit, et l\u2019inhibition de H19 peut \u00eatre un potentiel\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le traitement gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/therapeutic-procedure\">traitement<\/a>\u00a0pour les l\u00e9sions d&#039;isch\u00e9mie-reperfusion\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib84\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib84\"><span class=\"anchor-text\">[84]<\/span><\/a>. Dans la pyroptose m\u00e9di\u00e9e par l&#039;inflammasome AIM2 capable de provoquer une l\u00e9sion d&#039;isch\u00e9mie-reperfusion, l&#039;axe lincRNA MEG3\/miR-485\/AIM2 favorise la pyroptose en activant la signalisation caspase1 pendant le CIRI, et cet axe peut donc \u00eatre une cible th\u00e9rapeutique efficace pour\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le SI gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/brain-ischemia\">EST<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib84\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib84\"><span class=\"anchor-text\">[84]<\/span><\/a>. Pour le\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la r\u00e9gulation immunitaire gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunoregulation\">r\u00e9gulation immunitaire<\/a>\u00a0de microglies, Wang et al. d\u00e9couvert que LncRNA-Fendrr prot\u00e8ge le\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019ubiquitination gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ubiquitination\">ubiquitination<\/a>\u00a0et d\u00e9gradation de la prot\u00e9ine NLRC4 via HERC2 et r\u00e9gule la pyroptose microgliale\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib85\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib85\"><span class=\"anchor-text\">[85]<\/span><\/a>. Zhang et coll. ont d\u00e9couvert que l&#039;axe lncRNA NEAT1\/miR-22-3p inhibait la pyroptose et att\u00e9nuait les l\u00e9sions du CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib86\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib86\"><span class=\"anchor-text\">[86]<\/span><\/a>. Des exp\u00e9riences in vitro sur les l\u00e9sions par privation d&#039;oxyg\u00e8ne et de glucose (OGD) apr\u00e8s IS ont montr\u00e9 que les OGD augmentaient l&#039;expression de la prot\u00e9ine 3 du r\u00e9cepteur de type NOD (NLRP3) pour induire la mort pyroptotique des NSC, qui a \u00e9t\u00e9 sauv\u00e9e par\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019oxyg\u00e9noth\u00e9rapie hyperbare gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hyperbaric-medicine\">oxyg\u00e9noth\u00e9rapie hyperbare<\/a>. L&#039;ARNnc-H19 r\u00e9gul\u00e9 positivement agit comme une \u00e9ponge mol\u00e9culaire pour miR-423\u20135p, ciblant NLRP3 apr\u00e8s OGD pour induire la pyroptose des cellules souches neurales (NSC). Par cons\u00e9quent, il a \u00e9t\u00e9 confirm\u00e9 que l\u2019oxyg\u00e9noth\u00e9rapie hyperbare prot\u00e8ge les NSC de la pyroptose en inhibant l\u2019axe lncRNA-H19\/miR-423-5p\/NLRP3.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib87\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib87\"><span class=\"anchor-text\">[87]<\/span><\/a>. miR-21 est un\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les microARN gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microrna\">microARN<\/a>\u00a0(miARN) qui est \u00e9troitement li\u00e9 \u00e0 l\u2019apparition de la pyroptose. Des \u00e9tudes ont montr\u00e9 que miR-21 peut r\u00e9guler sp\u00e9cifiquement la prot\u00e9ine NLRP3, activer la prot\u00e9ine NLRP3, stimuler la s\u00e9cr\u00e9tion de NLRP3 et s&#039;exprimer dans les macrophages via la signalisation NF-\u03baB via la voie de r\u00e9troaction inflammatoire.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib88\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib88\"><span class=\"anchor-text\">[88]<\/span><\/a>. En plus d&#039;activer NLRP3, miR-21 peut \u00e9galement r\u00e9guler l&#039;activation de la caspase-1 en aval, favoriser la s\u00e9cr\u00e9tion d&#039;IL-1\u03b2 et favoriser l&#039;apparition de la pyroptose. Lorsque miR-21 est d\u00e9ficient, l\u2019expression de la voie de la caspase-1 r\u00e9gul\u00e9e par NLRP3 est consid\u00e9rablement r\u00e9duite. Par cons\u00e9quent, le niveau d\u2019expression de miR-21 constitue \u00e9galement un lien cl\u00e9 dans la r\u00e9gulation de l\u2019apparition de la pyroptose.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib89\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib89\"><span class=\"anchor-text\">[89]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib90\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib90\"><span class=\"anchor-text\">[90]<\/span><\/a>. Des \u00e9tudes de biologie mol\u00e9culaire modernes ont montr\u00e9 que miR-214-3p poss\u00e8de un site de liaison pour la caspase-1, qui peut se lier sp\u00e9cifiquement \u00e0 l&#039;apparition de la caspase-1, r\u00e9gulant ainsi la r\u00e9ponse inflammatoire et augmentant l&#039;incidence de la pyroptose.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib91\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib91\"><span class=\"anchor-text\">[91]<\/span><\/a>.<\/p>\n<div>\n<p id=\"p0065\">Le m\u00e9canisme mol\u00e9culaire de la pyroptose a \u00e9t\u00e9 r\u00e9sum\u00e9 dans\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#fig0005\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"fig0005\"><span class=\"anchor-text\">Fig. 1<\/span><\/a>.<\/p>\n<figure id=\"fig0005\" class=\"figure text-xs\"><img decoding=\"async\" src=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr1.jpg\" alt=\"Fig. 1\" height=\"414\" aria-describedby=\"cap0005\" \/><\/p>\n<ol class=\"u-margin-s-bottom\">\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"T\u00e9l\u00e9charger l&#039;image haute r\u00e9solution (294 Ko)\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr1_lrg.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">T\u00e9l\u00e9charger :\u00a0<span class=\"download-link-title\">T\u00e9l\u00e9charger l&#039;image haute r\u00e9solution (294 Ko)<\/span><\/span><\/a><\/li>\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"T\u00e9l\u00e9charger l&#039;image en taille r\u00e9elle\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr1.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">T\u00e9l\u00e9charger :\u00a0<span class=\"download-link-title\">T\u00e9l\u00e9charger l&#039;image en taille r\u00e9elle<\/span><\/span><\/a><\/li>\n<\/ol>\n<p id=\"sp0005\"><span class=\"label\">Fig. 1<\/span>. Le m\u00e9canisme mol\u00e9culaire de la pyroptose (Les m\u00e9canismes de la pyroptose comprennent la voie canonique de l&#039;inflammasome et la voie non canonique de l&#039;inflammasome. La voie canonique de l&#039;inflammasome est d\u00e9clench\u00e9e par les DAMP ou les PAMP. La voie non canonique de l&#039;inflammasome est d\u00e9clench\u00e9e par le LPS des bact\u00e9ries extracellulaires \u00e0 Gram n\u00e9gatif. ou stimulation de la mort.Apr\u00e8s le d\u00e9clenchement, la pyroptose est d\u00e9clench\u00e9e par une s\u00e9rie d&#039;interactions intermol\u00e9culaires.\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le TLR gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/toll-like-receptor\">TLR<\/a>: R\u00e9cepteur de type Toll\u00a0; GSDM\u00a0:\u00a0Gsdermin\u00a0; NLRP3\u00a0: r\u00e9cepteur de type domaine d&#039;oligom\u00e9risation se liant aux nucl\u00e9otides\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le domaine de la pyrine gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyrin-domain\">domaine de la pyrine<\/a>\u00a0contenant 3\u00a0; DAMP\u00a0: mod\u00e8le mol\u00e9culaire associ\u00e9 aux dommages\u00a0; PAMP : mod\u00e8le mol\u00e9culaire associ\u00e9 \u00e0 un pathog\u00e8ne).<\/p>\n<\/figure>\n<\/div>\n<\/section>\n<section id=\"sec0045\">\n<h3 id=\"sect0065\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.4. La relation entre la pyroptose et d&#039;autres dommages cellulaires<\/h3>\n<p id=\"p0070\">De nombreux m\u00e9canismes sont impliqu\u00e9s dans la survenue d\u2019une l\u00e9sion d\u2019isch\u00e9mie-reperfusion c\u00e9r\u00e9brale. Les m\u00e9canismes connus sont li\u00e9s \u00e0 divers m\u00e9canismes tels que la r\u00e9ponse inflammatoire, le trouble des canaux calciques, l&#039;alt\u00e9ration de la fonction mitochondriale et l&#039;autophagie. La pyroptose est impliqu\u00e9e dans tous les aspects des l\u00e9sions d&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale et est \u00e9troitement li\u00e9e \u00e0 d&#039;autres l\u00e9sions.<\/p>\n<p id=\"p0075\">L&#039;apparition de la pyroptose et de l&#039;apoptose appartiennent toutes deux \u00e0 un mode de mort cellulaire, mais elles sont fondamentalement diff\u00e9rentes. L&#039;apoptose est une voie physiologique de mort cellulaire, tandis que la pyroptose est souvent associ\u00e9e \u00e0 une mort cellulaire pathologique apr\u00e8s une l\u00e9sion corporelle.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib92\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib92\"><span class=\"anchor-text\">[92]<\/span><\/a>. L&#039;autophagie est une sorte de ph\u00e9nom\u00e8ne d&#039;autophagie largement r\u00e9pandu dans\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les cellules eucaryotes gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/eukaryotic-cell\">des cellules eucaryotes<\/a>. L&#039;autophagie est g\u00e9n\u00e9ralement divis\u00e9e en trois types, \u00e0 savoir l&#039;autophagie m\u00e9di\u00e9e par un chaperon, la microautophagie et la macroautophagie. Il existe actuellement de nombreuses \u00e9tudes sur la macroautophagie\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib93\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib93\"><span class=\"anchor-text\">[93]<\/span><\/a>. L&#039;autophagie est un \u00e9l\u00e9ment indispensable du processus m\u00e9tabolique normal des cellules. L&#039;inhibition de l&#039;autophagie peut conduire \u00e0 l&#039;accumulation de substances nocives dans les tissus, organes ou cellules. Une activation excessive de l&#039;autophagie d\u00e9truira d&#039;importants organites intracellulaires et prot\u00e9ines essentielles, d\u00e9clenchant l&#039;apoptose autophagique\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib94\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib94\"><span class=\"anchor-text\">[94]<\/span><\/a>.<\/p>\n<p id=\"p0080\">La pyroptose et l\u2019autophagie sont inextricablement li\u00e9es. Dans des circonstances normales, l&#039;apparition de l&#039;autophagie et de la pyroptose in vivo se situe dans un \u00e9tat d&#039;\u00e9quilibre dynamique. Lorsque le corps d\u00e9veloppe une r\u00e9ponse inflammatoire \u00e0 des stimuli externes, l\u2019\u00e9quilibre entre autophagie et pyroptose est perturb\u00e9.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib95\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib95\"><span class=\"anchor-text\">[95]<\/span><\/a>. Par exemple, NF-\u03baB est un\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la voie de transduction du signal gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/signal-transduction-pathway\">voie de transduction du signal<\/a>\u00a0qui participe \u00e0 la transduction du signal de nombreux\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les voies de signal gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-signaling-pathway\">voies de signal<\/a>\u00a0pour r\u00e9aliser la transduction du signal. L&#039;\u00e9tude a r\u00e9v\u00e9l\u00e9 que chez les souris IS pr\u00e9sentant un knock-out du g\u00e8ne NF-\u03baB,\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur mTOR \u00e0 partir des pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mammalian-target-of-rapamycin\">mTOR<\/a>\u00a0l&#039;activit\u00e9 a \u00e9t\u00e9 inhib\u00e9e et les niveaux d&#039;autophagie ont \u00e9t\u00e9 am\u00e9lior\u00e9s. La voie d&#039;activation de signalisation de NF-\u03baB est constitu\u00e9e d&#039;un grand nombre de stimuli pour activer les kinases induites par NF-\u03baB, qui activent les trim\u00e8res I\u03baK\u03b1, I\u03baKB et I\u03baK\u03b3, entra\u00eenant la phosphorylation et la d\u00e9gradation de I\u03baB, et enfin activent la voie de signalisation NF-\u03baB. . Apr\u00e8s activation, NF-\u03baB p\u00e9n\u00e8tre dans la cellule et se lie sp\u00e9cifiquement \u00e0 son r\u00e9cepteur d&#039;ADN correspondant, stimulant ainsi la transcription des facteurs inflammatoires et favorisant l&#039;expression massive des facteurs inflammatoires TNF-\u03b1, IL-1\u03b2 et IL-6. Des \u00e9tudes ont montr\u00e9 que la voie de signalisation NF-\u03baB est impliqu\u00e9e dans la r\u00e9gulation de l&#039;activation des niveaux pr\u00e9- et post-transcriptionnels de la prot\u00e9ine pyroptotique cl\u00e9 NLRP3 pour induire la pyroptose. Les facteurs inflammatoires abondamment exprim\u00e9s peuvent induire une cascade inflammatoire dans le corps, induire une pyroptose et \u00e9largir davantage la r\u00e9ponse inflammatoire, aggravant ainsi les l\u00e9sions c\u00e9r\u00e9brales.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib96\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib96\"><span class=\"anchor-text\">[96]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib97\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib97\"><span class=\"anchor-text\">[97]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib98\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib98\"><span class=\"anchor-text\">[98]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0050\">\n<h3 id=\"sect0070\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.5. M\u00e9canismes de pyroptose et d&#039;inflammation impliqu\u00e9s dans l&#039;EI<\/h3>\n<p id=\"p0085\">Des cascades inflammatoires existent \u00e0 diff\u00e9rents stades de l\u2019EI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib99\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib99\"><span class=\"anchor-text\">[99]<\/span><\/a>. Aux premiers stades de l\u2019EI, le flux sanguin dans le cerveau ralentit et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les neutrophiles gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neutrophil\">neutrophiles<\/a>\u00a0adh\u00e9rer \u00e0 la\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les cellules endoth\u00e9liales gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/endothelial-cell\">cellules endotheliales<\/a>\u00a0des vaisseaux isch\u00e9miques, et une premi\u00e8re r\u00e9ponse inflammatoire aigu\u00eb commence\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib100\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib100\"><span class=\"anchor-text\">[100]<\/span><\/a>. Avec l&#039;apparition d&#039;une reperfusion apr\u00e8s une isch\u00e9mie c\u00e9r\u00e9brale, des facteurs inflammatoires exog\u00e8nes, des cellules inflammatoires et des facteurs inflammatoires traversent la barri\u00e8re h\u00e9mato-enc\u00e9phalique, entra\u00eenant l&#039;effet secondaire de l&#039;isch\u00e9mie apr\u00e8s reperfusion et conduisant \u00e0 la lib\u00e9ration d&#039;un grand nombre de facteurs d&#039;oxydation et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les radicaux libres gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/radical-chemistry\">radicaux libres<\/a>. \u00c0 ce moment-l\u00e0, les microglies du\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les tissus c\u00e9r\u00e9braux gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-tissue\">tissu c\u00e9r\u00e9bral<\/a>\u00a0sont progressivement activ\u00e9s en grande quantit\u00e9 et produisent davantage\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les m\u00e9diateurs inflammatoires gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammatory-mediator\">m\u00e9diateurs de l&#039;inflammation<\/a>. Ce type de m\u00e9diateurs inflammatoires peut suractiver les cellules endoth\u00e9liales du tissu c\u00e9r\u00e9bral et produire une grande quantit\u00e9 de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le facteur tissulaire gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/thromboplastin\">facteur tissulaire<\/a>\u00a0d&#039;accumuler la toxicit\u00e9 des acides amin\u00e9s. Cela aggrave encore la lib\u00e9ration de facteurs oxydatifs, de radicaux libres et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le monoxyde de carbone gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/carbon-monoxide\">monoxyde de carbone<\/a>, et active les voies de signalisation li\u00e9es \u00e0 la r\u00e9ponse inflammatoire telles que le NF-\u03baB, les r\u00e9cepteurs Toll-like et les r\u00e9cepteurs Nod-like (NLR)\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib101\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib101\"><span class=\"anchor-text\">[101]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib102\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib102\"><span class=\"anchor-text\">[102]<\/span><\/a>. Par exemple, les NLR, des \u00e9tudes ont montr\u00e9 qu&#039;il existe 23 membres de la famille des NLR, qui sont principalement exprim\u00e9s dans le cytoplasme cellulaire et jouent un r\u00f4le cl\u00e9 dans la r\u00e9ponse immunitaire inn\u00e9e de l&#039;organisme. Les membres de la famille NLR, Nalp1, Nalp3, Nalp5 et Ipaf, sont capables d&#039;activer l&#039;activation de la caspase-1 via le\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la prot\u00e9ine adaptatrice dans les pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/adaptor-protein\">prot\u00e9ine adaptatrice<\/a>\u00a0ASC, d\u00e9clenche une cascade de r\u00e9ponses inflammatoires et m\u00e9die la pyroptose\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib103\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib103\"><span class=\"anchor-text\">[103]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib104\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib104\"><span class=\"anchor-text\">[104]<\/span><\/a>. NLRP3 est un composant important des facteurs inflammatoires. NLRP3 contient trois domaines : PYD, NACHT et LRR, qui peuvent \u00eatre repr\u00e9sent\u00e9s par LRR-NACHT-PYD : PYD-CARD : CARD-CARDC un domaine spase. Il r\u00e9pond \u00e0 divers signaux de dommages endog\u00e8nes, de sorte que l&#039;activation de l&#039;inflammasome NLRP3 est consid\u00e9r\u00e9e comme le principal type de pyroptose.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib105\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib105\"><span class=\"anchor-text\">[105]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib106\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib106\"><span class=\"anchor-text\">[106]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib107\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib107\"><span class=\"anchor-text\">[107]<\/span><\/a>.<\/p>\n<p id=\"p0090\">Les inflammasomes sont des complexes prot\u00e9iques assembl\u00e9s apr\u00e8s que le corps re\u00e7oit des signaux d&#039;infection ou de dommages cellulaires et servent de plate-forme pour le recrutement et l&#039;activation de la pro-caspase-1. La prot\u00e9ine promotrice NLRP3 peut recruter de grandes quantit\u00e9s de procaspase-1 par oligom\u00e9risation \u00e0 l&#039;aide de la mol\u00e9cule adaptatrice de l&#039;inflammasome ASC.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib108\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib108\"><span class=\"anchor-text\">[108]<\/span><\/a>. La procaspase-1 est le pr\u00e9curseur de la caspase-1, et la caspase-1 active est responsable de la lyse rapide des cellules pour activer et lib\u00e9rer l&#039;IL-1\u03b2 et l&#039;IL-18 extracellulaires, ce qui aggrave encore la r\u00e9ponse inflammatoire. Par cons\u00e9quent, la survenue de la pyroptose est \u00e9troitement li\u00e9e \u00e0 l\u2019apparition d\u2019une r\u00e9ponse inflammatoire et \u00e0 la formation d\u2019inflammasomes. La survenue d&#039;une l\u00e9sion d&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale est plus \u00e9troitement li\u00e9e \u00e0 l&#039;interaction entre la pyroptose et la r\u00e9ponse inflammatoire.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib109\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib109\"><span class=\"anchor-text\">[109]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib110\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib110\"><span class=\"anchor-text\">[110]<\/span><\/a>. Surtout dans le syst\u00e8me nerveux central, les astrocytes induisent l\u2019activation et la prolif\u00e9ration des microglies et produisent un grand nombre de m\u00e9diateurs inflammatoires. Ces m\u00e9diateurs inflammatoires peuvent activer les cellules endoth\u00e9liales pour produire divers facteurs tissulaires, augmenter la toxicit\u00e9 de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les acides amin\u00e9s excitateurs gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/excitatory-amino-acid\">acides amin\u00e9s excitateurs<\/a>, et promouvoir la sortie de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019oxyde nitrique gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nitric-oxide\">l&#039;oxyde nitrique<\/a>\u00a0et les radicaux libres d&#039;oxyg\u00e8ne. Les substances ci-dessus conduisent en outre \u00e0 l\u2019activation de multiples voies de transduction du signal inflammatoire telles que NF-\u03baB et JNK2\/STAT3, et favorisent l\u2019assemblage d\u2019inflammasomes tels que NLRP1 et NLRP3. La caspase-1 activ\u00e9e induit une pyroptose des cellules, \u00e9tend la r\u00e9ponse inflammatoire et aggrave les l\u00e9sions d&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib111\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib111\"><span class=\"anchor-text\">[111]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib112\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib112\"><span class=\"anchor-text\">[112]<\/span><\/a>. Certaines \u00e9tudes ont montr\u00e9 que, par rapport aux souris de type sauvage, les niveaux d&#039;AIM2 et d&#039;IL-1\u03b2 dans le cerveau d&#039;AIM2\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les souris knock-out gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/knockout-mouse\">souris knock-out<\/a>\u00a0apr\u00e8s isch\u00e9mie-reperfusion c\u00e9r\u00e9brale ont \u00e9t\u00e9 significativement diminu\u00e9es, le volume de l&#039;infarctus a \u00e9t\u00e9 significativement r\u00e9duit et la\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la fonction neurologique gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nervous-system-physiology\">fonction neurologique<\/a>\u00a0les scores ont \u00e9galement \u00e9t\u00e9 consid\u00e9rablement am\u00e9lior\u00e9s. L&#039;inhibition de l&#039;activation de l&#039;inflammasome AIM2 peut inhiber dans une certaine mesure l&#039;apparition de la pyroptose, r\u00e9duisant ainsi les l\u00e9sions c\u00e9r\u00e9brales isch\u00e9miques\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib113\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib113\"><span class=\"anchor-text\">[113]<\/span><\/a>. Par cons\u00e9quent, la pyroptose joue un r\u00f4le important dans le processus de l\u00e9sion d\u2019isch\u00e9mie-reperfusion c\u00e9r\u00e9brale. L&#039;inflammasome NLRP3 est une prot\u00e9ine cl\u00e9 de la voie pyroptotique, et l&#039;inhibition de son expression peut simultan\u00e9ment inhiber l&#039;expression de prot\u00e9ines li\u00e9es \u00e0 la voie pyroptotique en aval, limiter la r\u00e9ponse inflammatoire et att\u00e9nuer les l\u00e9sions d&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale.<\/p>\n<\/section>\n<section id=\"sec0055\">\n<h3 id=\"sect0075\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.6. La pyroptose et les l\u00e9sions mitochondriales sont \u00e0 l&#039;origine des l\u00e9sions de stress oxydatif apr\u00e8s l&#039;EI<\/h3>\n<p id=\"p0095\">Les mitochondries sont principalement impliqu\u00e9es dans la respiration a\u00e9robie des cellules et sont le lieu o\u00f9 se produit la respiration a\u00e9robie. Les mitochondries fournissent une base ionis\u00e9e pour la transmission normale du signal entre les cellules et la transduction du signal des cellules nerveuses\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib114\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib114\"><span class=\"anchor-text\">[114]<\/span><\/a>. Les dommages mitochondriaux sont principalement caus\u00e9s par des anomalies\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le m\u00e9tabolisme mitochondrial gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitochondrial-respiration\">m\u00e9tabolisme mitochondrial<\/a>\u00a0et dommages oxydatifs\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib115\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib115\"><span class=\"anchor-text\">[115]<\/span><\/a>. Des \u00e9tudes ont montr\u00e9 que les l\u00e9sions d&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale sont \u00e9troitement li\u00e9es au dysfonctionnement mitochondrial\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib116\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib116\"><span class=\"anchor-text\">[116]<\/span><\/a>. Le stress oxydatif, en tant que cl\u00e9 de l&#039;apparition de dommages oxydatifs, est \u00e9troitement li\u00e9 \u00e0 la pyroptose\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib117\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib117\"><span class=\"anchor-text\">[117]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib118\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib118\"><span class=\"anchor-text\">[118]<\/span><\/a>. Le stress oxydatif est plus susceptible de s&#039;exprimer par des l\u00e9sions des tissus c\u00e9r\u00e9braux, en particulier par l&#039;isch\u00e9mie c\u00e9r\u00e9brale et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les l\u00e9sions de reperfusion gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/reperfusion-injury\">l\u00e9sion de reperfusion<\/a>\u00a0apr\u00e8s une isch\u00e9mie c\u00e9r\u00e9brale\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib119\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib119\"><span class=\"anchor-text\">[119]<\/span><\/a>. Lorsque le corps est attaqu\u00e9 par des substances nocives externes, les cellules peuvent s\u00e9cr\u00e9ter une grande quantit\u00e9 de substances nocives.\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur ROS gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/reactive-oxygen-species\">ROS<\/a>\u00a0et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le charbon actif gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/activated-charcoal\">charbon actif<\/a>, qui perturbe l\u2019\u00e9quilibre entre oxydation et anti-oxydation, entra\u00eenant une s\u00e9rie de r\u00e9actions de dommages oxydatifs\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib120\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib120\"><span class=\"anchor-text\">[120]<\/span><\/a>. La plupart des ROS sont s\u00e9cr\u00e9t\u00e9es par les mitochondries\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib121\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib121\"><span class=\"anchor-text\">[121]<\/span><\/a>. Lorsqu\u2019il est stimul\u00e9 par des stimuli externes ou qu\u2019un dommage endog\u00e8ne se produit, le corps stimule la liaison des nucl\u00e9otides \u00e0 NLRP3 en induisant des niveaux \u00e9lev\u00e9s de ROS, activant ainsi le complexe prot\u00e9ique de l\u2019inflammasome. Lorsque les ROS sont suractiv\u00e9es, l\u2019ordre normal des voies de signalisation dans le corps est perturb\u00e9, entra\u00eenant la destruction du mat\u00e9riel g\u00e9n\u00e9tique, des prot\u00e9ines et de divers organites (y compris les mitochondries) dans les cellules. Lorsque divers organites tels que les mitochondries dans les cellules sont endommag\u00e9s, les cellules ont une nutrition et un m\u00e9tabolisme anormaux, et les ROS peuvent aggraver davantage les dommages caus\u00e9s aux cellules.\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019endoth\u00e9lium vasculaire gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascular-endothelium\">endoth\u00e9lium vasculaire<\/a>\u00a0et provoquer la perturbation du\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la microcirculation gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microcirculation\">microcirculation<\/a>\u00a0dans le cerveau. Le trouble de la perm\u00e9abilit\u00e9 de la barri\u00e8re h\u00e9mato-enc\u00e9phalique dans le cerveau induit la surexpression de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les mol\u00e9cules d\u2019adh\u00e9sion cellulaire gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-adhesion-molecule\">mol\u00e9cules d&#039;adh\u00e9sion cellulaire<\/a>, aggravant ainsi les l\u00e9sions c\u00e9r\u00e9brales\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib122\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib122\"><span class=\"anchor-text\">[122]<\/span><\/a>. Entre-temps,\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le stress oxydatif gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/oxidative-stress\">stress oxydatif<\/a>\u00a0am\u00e8ne les cellules \u00e0 pr\u00e9senter progressivement un mode de mort cellulaire caract\u00e9ris\u00e9 par une augmentation\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la perm\u00e9abilit\u00e9 des membranes cellulaires gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-membrane-permeability\">perm\u00e9abilit\u00e9 de la membrane cellulaire<\/a>\u00a0et la lib\u00e9ration du contenu cellulaire \u2013 pyroptose\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib120\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib120\"><span class=\"anchor-text\">[120]<\/span><\/a>. Par cons\u00e9quent, la pyroptose et les l\u00e9sions mitochondriales sont impliqu\u00e9es dans le processus pathologique de l\u00e9sion d\u2019isch\u00e9mie-reperfusion c\u00e9r\u00e9brale. Il a \u00e9t\u00e9 rapport\u00e9 que la prot\u00e9ine Drp1 li\u00e9e \u00e0 la motilit\u00e9 mitochondriale est une prot\u00e9ine cl\u00e9 n\u00e9cessaire aux mitochondries pour maintenir des fonctions physiologiques normales.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib123\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib123\"><span class=\"anchor-text\">[123]<\/span><\/a>. Lorsque l\u2019expression de Drp1 augmente, elle peut inhiber la\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la fission mitochondriale gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitochondrial-fission\">fission mitochondriale<\/a>\u00a0processus et r\u00e9duire le niveau de pyroptose, ralentissant ainsi l\u2019apparition de dommages\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib124\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib124\"><span class=\"anchor-text\">[124]<\/span><\/a>. Lorsque le corps re\u00e7oit une vari\u00e9t\u00e9 de stimuli de dommages endog\u00e8nes et exog\u00e8nes, le processus de r\u00e9gulation des voies de signalisation dans le corps change. Cela se manifeste par une diminution de la s\u00e9cr\u00e9tion de Drp1, des l\u00e9sions mitochondriales, un dysfonctionnement mitochondrial et une augmentation de l&#039;apoptose et de la pyroptose, entra\u00eenant diverses maladies dans le corps.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib125\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib125\"><span class=\"anchor-text\">[125]<\/span><\/a>. Des \u00e9tudes r\u00e9centes montrent que le dysfonctionnement mitochondrial induit l&#039;activation de l&#039;inflammasome NLRP3 lors d&#039;une l\u00e9sion d&#039;isch\u00e9mie\/reperfusion c\u00e9r\u00e9brale\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib126\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib126\"><span class=\"anchor-text\">[126]<\/span><\/a>. Mitochondriale\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le d\u00e9couplage de la prot\u00e9ine 2 \u00e0 partir des pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/uncoupling-protein-2\">prot\u00e9ine de d\u00e9couplage 2<\/a>\u00a0(UCP2) exacerbe les l\u00e9sions c\u00e9r\u00e9brales apr\u00e8s CIRI, et de nouvelles \u00e9tudes montrent que le d\u00e9ficit en UCP2 am\u00e9liore l&#039;activation de l&#039;inflammasome NLRP3 apr\u00e8s une exacerbation du CIRI induite par l&#039;hyperglyc\u00e9mie in vitro et in vivo. UCP2 pourrait \u00eatre une cible th\u00e9rapeutique potentielle pour l&#039;aggravation du CIRI induite par l&#039;hyperglyc\u00e9mie. Le d\u00e9ficit en UCP2 a \u00e9galement am\u00e9lior\u00e9 l&#039;activation de l&#039;inflammasome NLRP3 et la production de ROS dans les neurones in vitro et in vivo\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib127\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib127\"><span class=\"anchor-text\">[127]<\/span><\/a>.\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019adiponectine gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/adiponectin\">Adiponectine<\/a>\u00a0est une hormone d\u00e9riv\u00e9e du tissu adipeux ayant de larges effets antioxydants et anti-inflammatoires. Le peptide d&#039;adiponectine att\u00e9nue le stress oxydatif et l&#039;activation de l&#039;inflammasome NLRP3 apr\u00e8s une l\u00e9sion d&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale en r\u00e9gulant l&#039;AMPK\/GSK-3\u03b2\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib128\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib128\"><span class=\"anchor-text\">[128]<\/span><\/a>. Par cons\u00e9quent, dans l\u2019IS, il existe une relation \u00e9troite entre l\u2019apparition de la pyroptose et les l\u00e9sions mitochondriales, ainsi qu\u2019une interaction \u00e9troite entre les deux.<\/p>\n<\/section>\n<section id=\"sec0060\">\n<h3 id=\"sect0080\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.7. Le stress oxydatif\/le stress nitrosatif intervient dans la pyroptose apr\u00e8s une IS<\/h3>\n<p id=\"p0100\">Stress oxydatif\/nitrosatif et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la neuroinflammation gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroinflammation\">neuroinflammation<\/a>\u00a0sont la cl\u00e9\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les processus pathologiques gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathological-process\">processus pathologiques<\/a>\u00a0des l\u00e9sions d&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale, m\u00e9diatrices des l\u00e9sions neuronales, des l\u00e9sions de la barri\u00e8re h\u00e9mato-enc\u00e9phalique et de la transformation h\u00e9morragique au cours d&#039;un accident vasculaire c\u00e9r\u00e9bral isch\u00e9mique\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib129\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib129\"><span class=\"anchor-text\">[129]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib130\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib130\"><span class=\"anchor-text\">[130]<\/span><\/a>. Oxyde nitrique (NO) et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le peroxynitrite gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/peroxynitrite\">peroxynitrite<\/a>\u00a0(ONOO-) sont des RNS typiques du CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib130\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib130\"><span class=\"anchor-text\">[130]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib131\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib131\"><span class=\"anchor-text\">[131]<\/span><\/a>. Il existe 3 isom\u00e8res de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019oxyde nitrique synthase gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nitric-oxide-synthase\">monoxyde d&#039;azote synthase<\/a>:\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019oxyde nitrique synthase endoth\u00e9liale gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/endothelial-nitric-oxide-synthase\">monoxyde d&#039;azote synthase endoth\u00e9liale<\/a>\u00a0(eNOS) produit une faible concentration de NO et a des fonctions physiologiques\u00a0; alors que\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019oxyde nitrique synthase neuronale gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuronal-nitric-oxide-synthase\">monoxyde d&#039;azote synthase neuronale<\/a>\u00a0(nNOS) et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019oxyde nitrique synthase inductible gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inducible-nitric-oxide-synthase\">monoxyde d&#039;azote synthase inductible<\/a>\u00a0(iNOS) produisent des concentrations \u00e9lev\u00e9es de NO, ce qui induit une inflammation et augmente la perm\u00e9abilit\u00e9 de la barri\u00e8re h\u00e9mato-enc\u00e9phalique\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib132\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib132\"><span class=\"anchor-text\">[132]<\/span><\/a>. La surproduction de ROS\/RNS cr\u00e9e un microenvironnement stressant et conduit \u00e0 une s\u00e9rie de cascades de signalisation cellulaire, conduisant \u00e0 une inflammation, une hyperperm\u00e9abilit\u00e9 de la barri\u00e8re h\u00e9mato-enc\u00e9phalique,\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019\u0153d\u00e8me c\u00e9r\u00e9bral gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-edema\">\u0153d\u00e8me c\u00e9r\u00e9bral<\/a>\u00a0et la mort des cellules neuronales\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib133\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib133\"><span class=\"anchor-text\">[133]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib134\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib134\"><span class=\"anchor-text\">[134]<\/span><\/a>. Le peroxynitrite sert d&#039;interm\u00e9diaire\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le brin d\u2019ADN gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/dna-strand\">Brin d&#039;ADN<\/a>\u00a0brise et active le\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le ribozyme gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ribozyme\">ribozyme<\/a>\u00a0poly(ADP-ribose) synthase (PARS), \u00e9galement connue sous le nom de poly(ADP-ribose) polym\u00e9rase (PARP) ou poly(ADPribose)\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la transf\u00e9rase gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/transferase\">transf\u00e9rabilit\u00e9<\/a>\u00a0(pADPRT). ONOO- peut activer directement PARP\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib135\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib135\"><span class=\"anchor-text\">[135]<\/span><\/a>, et des exp\u00e9riences in vivo et in vitro ont d\u00e9montr\u00e9 le r\u00f4le de la voie de signalisation ONOO-\/PARP dans les l\u00e9sions c\u00e9r\u00e9brales isch\u00e9miques. Des exp\u00e9riences in vivo ont montr\u00e9 que les souris d\u00e9ficientes en NOS pr\u00e9sentaient moins d&#039;activation de PARP dans un mod\u00e8le animal d&#039;accident vasculaire c\u00e9r\u00e9bral isch\u00e9mique. Des exp\u00e9riences in vitro ont montr\u00e9 que les donneurs d&#039;ONOO, mais pas les donneurs de NO, induisaient de mani\u00e8re significative l&#039;activation de PARP dans les cellules C6 en culture.\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les cellules de gliome gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glioma-cell\">cellules de gliome<\/a>.\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la perturbation des g\u00e8nes gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/gene-disruption\">Perturbation g\u00e9n\u00e9tique<\/a>\u00a0ou la d\u00e9sactivation du PARP r\u00e9duit consid\u00e9rablement\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la taille de l\u2019infarctus c\u00e9r\u00e9bral gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-infarction-size\">taille de l&#039;infarctus c\u00e9r\u00e9bral<\/a>, att\u00e9nue\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la neurotoxicit\u00e9 gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neurotoxicity\">neurotoxicit\u00e9<\/a>, prot\u00e8ge les unit\u00e9s neurovasculaires et am\u00e9liore les r\u00e9sultats neurologiques\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib136\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib136\"><span class=\"anchor-text\">[136]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib137\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib137\"><span class=\"anchor-text\">[137]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib138\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib138\"><span class=\"anchor-text\">[138]<\/span><\/a>. Des \u00e9tudes ont montr\u00e9 que les ROS\/RNS peuvent \u00eatre un activateur de l&#039;inflammasome pendant le CIRI.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib139\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib139\"><span class=\"anchor-text\">[139]<\/span><\/a>. L&#039;inflammasome est un complexe multiprot\u00e9ique pr\u00e9sent dans le cytoplasme de la microglie, dont le r\u00e9cepteur NOD-like 3 (NLRP3) est le plus \u00e9tudi\u00e9. NLRP3 d\u00e9clenche et active la caspase-1, active l&#039;IL-1\u03b2 et l&#039;IL-18 et les lib\u00e8re dans le\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019espace extracellulaire gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/extracellular-space\">espace extracellulaire<\/a>, favorisant le d\u00e9veloppement de l&#039;inflammation\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib140\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib140\"><span class=\"anchor-text\">[140]<\/span><\/a>. Des exp\u00e9riences in vivo ont montr\u00e9 que la taille de l&#039;infarctus c\u00e9r\u00e9bral et les dommages caus\u00e9s par la BBB chez les souris knock-out NLPR3 \u00e9taient inf\u00e9rieurs \u00e0 ceux des souris de type sauvage. D&#039;autres exp\u00e9riences ont montr\u00e9 que NLRP3 pouvait m\u00e9dier la lib\u00e9ration d&#039;IL-1\u03b2 et augmenter la perm\u00e9abilit\u00e9 des cellules endoth\u00e9liales microvasculaires c\u00e9r\u00e9brales.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib141\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib141\"><span class=\"anchor-text\">[141]<\/span><\/a>. Li\u00e9 au facteur nucl\u00e9aire E2\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le facteur 2 gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/prothrombin\">facteur 2<\/a>\u00a0(Nrf2) r\u00e9gule les r\u00e9ponses antioxydantes cellulaires et Nrf2 inhibe la production de NLRP3 m\u00e9di\u00e9e par les ROS dans la microglie BV2 dans des conditions de privation d&#039;oxyg\u00e8ne et de glucose\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib142\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib142\"><span class=\"anchor-text\">[142]<\/span><\/a>. Il a \u00e9t\u00e9 constat\u00e9 que le stress oxydatif\/nitrosatif induit la formation de peroxynitrite, qui pourrait \u00eatre un d\u00e9clencheur cl\u00e9 de l&#039;activation de la caspase1\/inflammasome.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib143\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib143\"><span class=\"anchor-text\">[143]<\/span><\/a>. Par cons\u00e9quent, l\u2019inflammasome m\u00e9di\u00e9 par les ROS\/RNS pourrait constituer une cible th\u00e9rapeutique potentielle pour les l\u00e9sions c\u00e9r\u00e9brales isch\u00e9miques.<\/p>\n<p id=\"p0105\">De plus, ROS\/RNS intervient dans l\u2019activation des r\u00e9cepteurs Toll-like. Les \u00e9tudes actuelles ont montr\u00e9 que les r\u00e9cepteurs Toll-like (TLR) ont \u00e9t\u00e9 largement \u00e9tudi\u00e9s en tant que r\u00e9cepteur inn\u00e9.\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les r\u00e9cepteurs immunitaires gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immune-system-receptors\">r\u00e9cepteur immunitaire<\/a>, et TLR4\/2 ont \u00e9t\u00e9 davantage \u00e9tudi\u00e9s dans le domaine c\u00e9r\u00e9bral\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les l\u00e9sions isch\u00e9miques gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemic-injury\">blessure isch\u00e9mique<\/a>.\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur TLR4 gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/toll-like-receptor-4\">TLR4<\/a>\u00a0peut m\u00e9dier l&#039;expression de l&#039;IL-1\u03b2, de la MMP-9, de l&#039;iNOS et de la COX-2, et aggraver les l\u00e9sions c\u00e9r\u00e9brales induites par le stress oxydatif\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib144\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib144\"><span class=\"anchor-text\">[144]<\/span><\/a>. L&#039;application de l&#039;inhibiteur TLR4\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le E5564 \u00e0 partir des pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/eritoran\">E5564<\/a>\u00a0a montr\u00e9 qu&#039;il pouvait jouer un r\u00f4le\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les neuroprotecteurs gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroprotective-agent\">neuroprotecteur<\/a>\u00a0r\u00f4le en inhibant l\u2019activation des microglies et la production de ROS\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib145\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib145\"><span class=\"anchor-text\">[145]<\/span><\/a>. Apr\u00e8s IS, la taille de l&#039;infarctus des souris d\u00e9ficientes en TLR4 \u00e9tait nettement inf\u00e9rieure \u00e0 celle des souris de type sauvage\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib146\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib146\"><span class=\"anchor-text\">[146]<\/span><\/a>. TLR4 s\u2019implique \u00e9galement dans l\u2019apr\u00e8s-SI\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la neurogen\u00e8se gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neurogenesis\">neurogen\u00e8se<\/a>.\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la tomographie par \u00e9mission de positrons gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/positron-emission-tomography\">Tomographie par \u00e9mission de positrons<\/a>\u00a0des \u00e9tudes ont montr\u00e9 que les souris d\u00e9ficientes en TLR4 ont am\u00e9lior\u00e9 la neurogen\u00e8se et supprim\u00e9 les r\u00e9ponses inflammatoires dans l&#039;IS\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib147\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib147\"><span class=\"anchor-text\">[147]<\/span><\/a>. De plus, des \u00e9tudes exp\u00e9rimentales in vivo ont montr\u00e9 que l&#039;inhibition de la voie de signalisation TLR2\/4\/NF-\u03baB a un certain effet sur la r\u00e9gulation du stress oxydatif, la r\u00e9ponse inflammatoire et la protection du tissu c\u00e9r\u00e9bral isch\u00e9mique.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib148\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib148\"><span class=\"anchor-text\">[148]<\/span><\/a>. Par cons\u00e9quent, TLR4\/2 pourrait \u00eatre une cible th\u00e9rapeutique pour les l\u00e9sions c\u00e9r\u00e9brales isch\u00e9miques.<\/p>\n<\/section>\n<\/section>\n<section id=\"sec0065\">\n<h2 id=\"sect0085\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">3. La relation entre la pyroptose et l&#039;IS<\/h2>\n<p id=\"p0110\">Les m\u00e9canismes pathologiques du cerveau\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019isch\u00e9mie gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemia\">isch\u00e9mie<\/a>\u00a0et les l\u00e9sions post-isch\u00e9mie-reperfusion sont complexes. Les m\u00e9canismes impliqu\u00e9s dans ce processus comprennent l&#039;inflammation, le stress oxydatif, l&#039;autophagie, le dysfonctionnement mitochondrial, la surcharge en calcium et la mort cellulaire programm\u00e9e.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib149\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib149\"><span class=\"anchor-text\">[149]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib150\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib150\"><span class=\"anchor-text\">[150]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib151\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib151\"><span class=\"anchor-text\">[151]<\/span><\/a>. Un certain nombre d&#039;\u00e9tudes ont montr\u00e9 que la mort cellulaire programm\u00e9e joue un r\u00f4le important dans le processus pathologique de l&#039;isch\u00e9mie c\u00e9r\u00e9brale et des l\u00e9sions d&#039;isch\u00e9mie-reperfusion, et qu&#039;elle est \u00e9troitement li\u00e9e aux m\u00e9canismes ci-dessus, en particulier la pyroptose.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib152\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib152\"><span class=\"anchor-text\">[152]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib153\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib153\"><span class=\"anchor-text\">[153]<\/span><\/a>. La mort cellulaire programm\u00e9e est le principal \u00e9v\u00e9nement de l&#039;accident vasculaire c\u00e9r\u00e9bral isch\u00e9mique, impliquant les neurones,\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les microglies gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microglia\">microglie<\/a>, astrocytes,\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les cellules endoth\u00e9liales vasculaires gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascular-endothelial-cell\">cellules endoth\u00e9liales vasculaires<\/a>, etc., comme l&#039;apoptose\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib154\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib154\"><span class=\"anchor-text\">[154]<\/span><\/a>, autophagie\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib155\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib155\"><span class=\"anchor-text\">[155]<\/span><\/a>, n\u00e9crose programm\u00e9e ou n\u00e9croptose\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib156\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib156\"><span class=\"anchor-text\">[156]<\/span><\/a>,\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la ferroptose gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ferroptosis\">ferroptose<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib157\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib157\"><span class=\"anchor-text\">[157]<\/span><\/a>et la pyroptose\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib158\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib158\"><span class=\"anchor-text\">[158]<\/span><\/a>. En particulier dans la pyroptose, l&#039;expression de prot\u00e9ines li\u00e9es \u00e0 la pyroptose telles que NLRP1, ASC, Caspase-1 et GSDMD est augment\u00e9e dans un mod\u00e8le d&#039;isch\u00e9mie c\u00e9r\u00e9brale chez le rat, et l&#039;inhibition de NLRP1 peut att\u00e9nuer l&#039;inflammation et les troubles c\u00e9r\u00e9braux.\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les l\u00e9sions isch\u00e9miques gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemic-injury\">blessure isch\u00e9mique<\/a>. De plus, en cas d&#039;isch\u00e9mie c\u00e9r\u00e9brale chronique, les cellules favorisent les r\u00e9ponses inflammatoires en lib\u00e9rant des signaux tels que les DAMP et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les PAMP \u00e0 partir des pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathogen-associated-molecular-pattern\">PAMP<\/a>, et d\u00e9clenchent une s\u00e9rie de r\u00e9ponses mol\u00e9culaires complexes. \u00c0 ce moment-l\u00e0, les cellules inflammatoires neuro-immunes intracr\u00e2niennes, telles que les microglies et les astrocytes, semblent prolif\u00e9rer et s&#039;activer, ce qui endommage encore davantage l&#039;unit\u00e9 neurovasculaire.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib159\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib159\"><span class=\"anchor-text\">[159]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib160\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib160\"><span class=\"anchor-text\">[160]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib161\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib161\"><span class=\"anchor-text\">[161]<\/span><\/a>.<\/p>\n<section id=\"sec0070\">\n<h3 id=\"sect0090\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">3.1. Pyroptose et neurones<\/h3>\n<p id=\"p0115\">Apr\u00e8s l&#039;EI, une n\u00e9crose se produit rapidement dans la zone isch\u00e9mique centrale et les cellules mortes \u00e9mettent des signaux de danger tels que\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la prot\u00e9ine HMGB1 gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/high-mobility-group-b1-protein\">Prot\u00e9ine HMGB1<\/a>,\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les prot\u00e9ines de choc thermique gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/heat-shock-protein\">prot\u00e9ine de choc thermique<\/a>,\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la peroxydase gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/peroxidase\">peroxydase<\/a>\u00a0prot\u00e9ine de la famille, etc. Ces mol\u00e9cules de signal de danger se lient \u00e0\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les r\u00e9cepteurs de reconnaissance de formes gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pattern-recognition-receptor\">r\u00e9cepteurs de reconnaissance de formes<\/a>, formulaire\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les inflammasomes gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammasome\">inflammasomes<\/a>, d\u00e9clenchent des r\u00e9ponses immunitaires inn\u00e9es et provoquent la mort neuronale\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib162\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib162\"><span class=\"anchor-text\">[162]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib163\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib163\"><span class=\"anchor-text\">[163]<\/span><\/a>. Des \u00e9tudes ont confirm\u00e9 que l&#039;isch\u00e9mie c\u00e9r\u00e9brale peut conduire \u00e0 une expression \u00e9lev\u00e9e de NLRP1 et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur NLRP3 \u00e0 partir des pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nucleotide-binding-oligomerization-domain-like-receptor\">NLRP3<\/a>\u00a0dans le tissu c\u00e9r\u00e9bral isch\u00e9mique et les neurones, et l&#039;activation de NLRP1 existe principalement dans les neurones\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib164\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib164\"><span class=\"anchor-text\">[164]<\/span><\/a>. L&#039;utilisation d&#039;inhibiteurs de la caspase-1 ou de pr\u00e9parations d&#039;immunoglobulines peut att\u00e9nuer l&#039;expression de NLRP1 et NLRP3 dans les neurones corticaux primaires et r\u00e9duire la taille de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019infarctus c\u00e9r\u00e9bral gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-infarction\">infarctus c\u00e9r\u00e9bral<\/a>, et le m\u00e9canisme peut \u00eatre li\u00e9 \u00e0 l&#039;inhibition de l&#039;activation des voies NF-\u03baB et MAPK\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib164\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib164\"><span class=\"anchor-text\">[164]<\/span><\/a>. Chez les souris IS, Li et al.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib165\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib165\"><span class=\"anchor-text\">[165]<\/span><\/a>\u00a0a constat\u00e9 que le 3\u00e8me jour apr\u00e8s l&#039;isch\u00e9mie c\u00e9r\u00e9brale, des dommages ultrastructuraux du plasma neuronal, nucl\u00e9aire et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les membranes mitochondriales gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitochondrial-membrane\">membranes mitochondriales<\/a>\u00a0s&#039;est produit et les expressions de la caspase-1, du GSDMD et de l&#039;IL-1\u03b2 ont \u00e9t\u00e9 significativement augment\u00e9es. L&#039;inhibiteur de la Caspase-1\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le Vx765 gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/belnacasan\">Vx765<\/a>\u00a0peut inhiber la pyroptose, favoriser la survie des neurones dans les zones isch\u00e9miques et am\u00e9liorer\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le dysfonctionnement c\u00e9r\u00e9bral gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-dysfunction\">dysfonctionnement c\u00e9r\u00e9bral<\/a>\u00a0Chez la souris. Liang et coll.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib166\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib166\"><span class=\"anchor-text\">[166]<\/span><\/a>\u00a0ont d\u00e9couvert que le g\u00e8ne 3 (MEG3) exprim\u00e9 par la m\u00e8re \u00e0 ARN long non codant favorise la pyroptose et les r\u00e9ponses inflammatoires en activant la voie AIM2\/Caspase-1, entra\u00eenant des l\u00e9sions d&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale. L&#039;inactivation du g\u00e8ne MEG3 peut inhiber l&#039;expression de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur AIM2 gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nodular-melanoma\">OBJECTIF2<\/a>, Caspase-1, GSDMD et d&#039;autres prot\u00e9ines, et att\u00e9nuent les l\u00e9sions c\u00e9r\u00e9brales isch\u00e9miques. Cela sugg\u00e8re que MEG3 pourrait \u00eatre une cible th\u00e9rapeutique efficace pour les accidents vasculaires c\u00e9r\u00e9braux isch\u00e9miques.<\/p>\n<\/section>\n<section id=\"sec0075\">\n<h3 id=\"sect0095\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">3.2. Pyroptose et astrocytes<\/h3>\n<p id=\"p0120\">Les astrocytes sont les plus abondants\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les cellules gliales gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glial-cells\">cellules gliales<\/a>\u00a0dans le\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le syst\u00e8me nerveux central gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/central-nervous-system\">syst\u00e8me nerveux central<\/a>\u00a0et sont impliqu\u00e9s dans la formation de la barri\u00e8re h\u00e9mato-enc\u00e9phalique, r\u00e9gulant le m\u00e9tabolisme neuronal et stabilisant la communication intercellulaire\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib167\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib167\"><span class=\"anchor-text\">[167]<\/span><\/a>. Apr\u00e8s l&#039;EI, un changement pathologique important est r\u00e9actif\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019astrogliose gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/astrocytosis\">astrogliose<\/a>\u00a0et les cicatrices gliales, qui favorisent la plasticit\u00e9 neuronale peu apr\u00e8s une l\u00e9sion isch\u00e9mique\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib168\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib168\"><span class=\"anchor-text\">[168]<\/span><\/a>. On pense g\u00e9n\u00e9ralement que lorsque le\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019hippocampe gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hippocampus\">hippocampe<\/a>\u00a0est l&#039;isch\u00e9mie et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019hypoxie gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hypoxia\">hypoxie<\/a>, le\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la capacit\u00e9 antioxydante gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antioxidant-capacity\">capacit\u00e9 antioxydante<\/a>\u00a0de l&#039;hippocampe sera affaibli et un grand nombre de facteurs inflammatoires pourront \u00eatre lib\u00e9r\u00e9s, aggravant ainsi les dommages caus\u00e9s \u00e0 l&#039;hippocampe\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib169\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib169\"><span class=\"anchor-text\">[169]<\/span><\/a>. Trois (3) heures apr\u00e8s une isch\u00e9mie c\u00e9r\u00e9brale focale\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les rats SD gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/sprague-dawley-rat\">Rats SD<\/a>, des cellules immunor\u00e9actives positives de type IL-1\u03b2 sont apparues dans la zone isch\u00e9mique, principalement des astrocytes inactiv\u00e9s. Jusqu&#039;\u00e0 2 mois apr\u00e8s l&#039;isch\u00e9mie, les cellules positives peuvent encore \u00eatre d\u00e9tect\u00e9es dans l&#039;h\u00e9misph\u00e8re isch\u00e9mique, notamment autour des foyers n\u00e9crotiques, et plus le degr\u00e9 d&#039;activation est \u00e9lev\u00e9.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib170\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib170\"><span class=\"anchor-text\">[170]<\/span><\/a>. Les astrocytes activ\u00e9s peuvent induire la lib\u00e9ration de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le facteur de n\u00e9crose tumorale gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tumor-necrosis-factor\">facteur de n\u00e9crose tumoral<\/a>, l&#039;interleukine, le facteur de croissance et d&#039;autres facteurs inflammatoires ou m\u00e9diateurs neuronaux toxiques, entra\u00eenant des l\u00e9sions neuronales\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib171\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib171\"><span class=\"anchor-text\">[171]<\/span><\/a>. NLRP2 est principalement exprim\u00e9 dans les astrocytes, mais peu dans les neurones et les microglies. De plus, l&#039;expression de NLRP2 \u00e9tait significativement r\u00e9gul\u00e9e positivement dans le mod\u00e8le d&#039;isch\u00e9mie c\u00e9r\u00e9brale de souris et apr\u00e8s une privation d&#039;oxyg\u00e8ne et de glucose dans les astrocytes, et la d\u00e9sactivation de NLRP2 pourrait r\u00e9duire la pyroptose induite par la privation d&#039;oxyg\u00e8ne et de glucose.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib172\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib172\"><span class=\"anchor-text\">[172]<\/span><\/a>. Une autre \u00e9tude a r\u00e9v\u00e9l\u00e9 que dans un mod\u00e8le in vitro d&#039;isch\u00e9mie c\u00e9r\u00e9brale, la privation d&#039;oxyg\u00e8ne et de glucose entra\u00eenait une augmentation de NLRP3, ASC, Caspase-1, IL-1\u03b2 et IL-18, ainsi qu&#039;une diminution de la survie des astrocytes.\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019hispiduline gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hispidulin\">Hispiduline<\/a>\u00a0est un compos\u00e9 c\u00e9tonique isol\u00e9 de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la phytoth\u00e9rapie chinoise gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chinese-herbal-medicine\">Phytoth\u00e9rapie chinoise<\/a>. Des exp\u00e9riences in vitro et in vivo ont montr\u00e9 que l&#039;hispiduline peut inhiber la pyroptose m\u00e9di\u00e9e par NLRP3 et exercer un effet protecteur sur le cerveau, et son m\u00e9canisme est li\u00e9 \u00e0 l&#039;activation de l&#039;AMPK\/GSK-3\u03b2.\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la voie de signalisation gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/signal-transduction\">voie de signalisation<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib173\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib173\"><span class=\"anchor-text\">[173]<\/span><\/a>. Meng et coll.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib174\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib174\"><span class=\"anchor-text\">[174]<\/span><\/a>\u00a0ont d\u00e9couvert que l&#039;expression de NLRP6 atteignait un pic 48 heures apr\u00e8s l&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale chez le rat. Apr\u00e8s une privation d&#039;oxyg\u00e8ne et de glucose dans les astrocytes, la production de NLRP6 et de ses produits d&#039;activation augmente, et la d\u00e9sactivation de NLRP6 peut r\u00e9duire l&#039;ASC et la Caspase-1, r\u00e9duire la lib\u00e9ration de facteurs inflammatoires et augmenter l&#039;activit\u00e9 neuronale.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib175\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib175\"><span class=\"anchor-text\">[175]<\/span><\/a>. Par cons\u00e9quent, les interventions ciblant l\u2019activation de l\u2019inflammasome dans les astrocytes pourraient fournir de nouvelles id\u00e9es pour le traitement de l\u2019IS.<\/p>\n<\/section>\n<section id=\"sec0080\">\n<h3 id=\"sect0100\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">3.3. Pyroptose et microglie<\/h3>\n<p id=\"p0125\">Les microglies sont inn\u00e9es\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les cellules immunitaires gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunocompetent-cell\">cellules immunitaires<\/a>\u00a0du syst\u00e8me nerveux central et des premi\u00e8res cellules activ\u00e9es apr\u00e8s un accident vasculaire c\u00e9r\u00e9bral isch\u00e9mique\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib176\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib176\"><span class=\"anchor-text\">[176]<\/span><\/a>. Dans la phase aigu\u00eb d&#039;une isch\u00e9mie c\u00e9r\u00e9brale, les microglies migrent rapidement vers le site de la l\u00e9sion et s\u00e9cr\u00e8tent des facteurs inflammatoires et des substances cytotoxiques, aggravant les l\u00e9sions tissulaires.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib177\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib177\"><span class=\"anchor-text\">[177]<\/span><\/a>. En phase chronique, la microglie peut produire des cytokines anti-inflammatoires et des facteurs de croissance pour favoriser\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la r\u00e9paration tissulaire gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tissue-repair\">r\u00e9paration des tissus<\/a>\u00a0et remodelage\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib178\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib178\"><span class=\"anchor-text\">[178]<\/span><\/a>. Des \u00e9tudes ont montr\u00e9 que la pyroptose microgliale joue un r\u00f4le important dans les l\u00e9sions c\u00e9r\u00e9brales isch\u00e9miques. NLRC4 a \u00e9t\u00e9 le premier inflammasome \u00e0 augmenter de mani\u00e8re significative lorsque les microglies \u00e9taient priv\u00e9es d&#039;oxyg\u00e8ne et de glucose pendant 3 heures, tandis que NLRP1, NLRP3 et AIM2 n&#039;\u00e9taient significativement augment\u00e9s qu&#039;apr\u00e8s 6 heures de privation d&#039;oxyg\u00e8ne et de glucose. La d\u00e9sactivation de NLRC4 peut r\u00e9duire la production de GSDMD, d&#039;IL-1\u03b2 et d&#039;IL-18 et inhiber la pyroptose microgliale\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib179\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib179\"><span class=\"anchor-text\">[179]<\/span><\/a>. Xu et coll.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib180\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib180\"><span class=\"anchor-text\">[180]<\/span><\/a>\u00a0rapport\u00e9 que le r\u00e9cepteur conducteur 1 (TREM-1) exprim\u00e9 par\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les cellules my\u00e9lo\u00efdes gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/myeloid-cell\">cellules my\u00e9lo\u00efdes<\/a>\u00a0dans les microglies apr\u00e8s une isch\u00e9mie-reperfusion c\u00e9r\u00e9brale peut activer la voie de la pyroptose m\u00e9di\u00e9e par NLRP3\/Caspase-1 et induire des r\u00e9ponses neuroinflammatoires. L&#039;inhibition de TREM-1 r\u00e9duit la pyroptose microgliale et les l\u00e9sions nerveuses. Li et coll.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib181\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib181\"><span class=\"anchor-text\">[181]<\/span><\/a>\u00a0ont confirm\u00e9 que l&#039;expression de la guanosine monophosphate-ad\u00e9nosine synthase cyclique (cGAS) est r\u00e9gul\u00e9e positivement apr\u00e8s une isch\u00e9mie c\u00e9r\u00e9brale et active l&#039;inflammasome AIM2 pour induire une pyroptose microgliale. L&#039;antagoniste du GASc A151 peut inhiber l&#039;activation de l&#039;AIM2 et la pyroptose microgliale, r\u00e9duire consid\u00e9rablement le volume de l&#039;infarctus c\u00e9r\u00e9bral et att\u00e9nuer les l\u00e9sions nerveuses. Les \u00e9tudes ci-dessus indiquent que la pyroptose des microglies et sa r\u00e9ponse neuroinflammatoire m\u00e9di\u00e9e peuvent constituer un m\u00e9canisme important conduisant \u00e0 des l\u00e9sions c\u00e9r\u00e9brales isch\u00e9miques. L&#039;inhibition des effets neurotoxiques des microglies pourrait constituer une nouvelle strat\u00e9gie pour le traitement de l&#039;accident vasculaire c\u00e9r\u00e9bral isch\u00e9mique.<\/p>\n<\/section>\n<section id=\"sec0085\">\n<h3 id=\"sect0105\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">3.4. Pyroptose et cellules endoth\u00e9liales<\/h3>\n<p id=\"p0130\">Les cellules endoth\u00e9liales constituent la premi\u00e8re barri\u00e8re de la barri\u00e8re h\u00e9mato-enc\u00e9phalique, fournissant un \u00e9chafaudage pour\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la claudine gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/claudin\">claudine<\/a>,\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les mol\u00e9cules d\u2019adh\u00e9sion gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-adhesion-molecule\">mol\u00e9cules d&#039;adh\u00e9sion<\/a>\u00a0et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la matrice extracellulaire gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/extracellular-matrix\">matrice extracellulaire<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib182\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib182\"><span class=\"anchor-text\">[182]<\/span><\/a>. Lors d&#039;une isch\u00e9mie c\u00e9r\u00e9brale, la r\u00e9ponse immuno-inflammatoire et le stress oxydatif peuvent endommager\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les cellules endoth\u00e9liales gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/endothelial-cell\">cellules endotheliales<\/a>\u00a0et perturbent l&#039;int\u00e9grit\u00e9 de la barri\u00e8re h\u00e9mato-enc\u00e9phalique, entra\u00eenant un \u0153d\u00e8me vasog\u00e9nique, une transformation h\u00e9morragique et une mortalit\u00e9 accrue\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib183\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib183\"><span class=\"anchor-text\">[183]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib184\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib184\"><span class=\"anchor-text\">[184]<\/span><\/a>. Apr\u00e8s une isch\u00e9mie c\u00e9r\u00e9brale, NLRP3 est r\u00e9gul\u00e9 positivement dans les neurones, les microglies et les cellules endoth\u00e9liales vasculaires, et la d\u00e9sactivation du g\u00e8ne NLRP3 peut r\u00e9duire le volume de l&#039;infarctus c\u00e9r\u00e9bral chez les souris atteintes.\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019art\u00e8re c\u00e9r\u00e9brale moyenne gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/middle-cerebral-artery\">art\u00e8re c\u00e9r\u00e9brale moyenne<\/a>\u00a0isch\u00e9mie et r\u00e9duire la perm\u00e9abilit\u00e9 de la barri\u00e8re h\u00e9mato-enc\u00e9phalique\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib185\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib185\"><span class=\"anchor-text\">[185]<\/span><\/a>. Wang et coll.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib186\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib186\"><span class=\"anchor-text\">[186]<\/span><\/a>\u00a0ont confirm\u00e9 que l&#039;isch\u00e9mie c\u00e9r\u00e9brale peut induire une pyroptose des cellules endoth\u00e9liales microvasculaires et aggraver les l\u00e9sions d&#039;isch\u00e9mie-reperfusion. Ils ont \u00e9galement d\u00e9couvert que l&#039;activation du coactivateur gamma 1\u03b1 (PGC-1\u03b1) du r\u00e9cepteur activ\u00e9 par les prolif\u00e9rateurs de peroxysomes r\u00e9duisait de mani\u00e8re significative l&#039;expression des prot\u00e9ines li\u00e9es \u00e0 la pyroptose et augmentait l&#039;expression de ZO-1 et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019Occludine gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/occludin\">Occludine<\/a>\u00a0prot\u00e9ines dans les cellules endoth\u00e9liales microvasculaires du cerveau, afin de prot\u00e9ger l\u2019int\u00e9grit\u00e9 de la barri\u00e8re h\u00e9mato-enc\u00e9phalique. En outre, des \u00e9tudes ont montr\u00e9 que la pyroptose des cellules endoth\u00e9liales microvasculaires c\u00e9r\u00e9brales peut augmenter le risque d&#039;h\u00e9morragie apr\u00e8s une IS, entra\u00eenant des complications graves telles que\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019h\u00e9morragie c\u00e9r\u00e9brale gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebral-hemorrhage\">h\u00e9morragie c\u00e9r\u00e9brale<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib187\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib187\"><span class=\"anchor-text\">[187]<\/span><\/a>.<\/p>\n<div>\n<p id=\"p0135\">L&#039;association entre l&#039;isch\u00e9mie c\u00e9r\u00e9brale et la pyroptose est r\u00e9sum\u00e9e dans\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#fig0010\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"fig0010\"><span class=\"anchor-text\">Figure 2<\/span><\/a>.<\/p>\n<figure id=\"fig0010\" class=\"figure text-xs\"><img decoding=\"async\" src=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr2.jpg\" alt=\"Fig. 2\" height=\"362\" aria-describedby=\"cap0010\" \/><\/p>\n<ol class=\"u-margin-s-bottom\">\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"T\u00e9l\u00e9charger l&#039;image haute r\u00e9solution (274 Ko)\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr2_lrg.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">T\u00e9l\u00e9charger :\u00a0<span class=\"download-link-title\">T\u00e9l\u00e9charger l&#039;image haute r\u00e9solution (274 Ko)<\/span><\/span><\/a><\/li>\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"T\u00e9l\u00e9charger l&#039;image en taille r\u00e9elle\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr2.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">T\u00e9l\u00e9charger :\u00a0<span class=\"download-link-title\">T\u00e9l\u00e9charger l&#039;image en taille r\u00e9elle<\/span><\/span><\/a><\/li>\n<\/ol>\n<p id=\"sp0010\"><span class=\"label\">Figure 2<\/span>. R\u00e9sum\u00e9 du m\u00e9canisme de la pyroptose dans les unit\u00e9s neuronales vasculaires apr\u00e8s IS [M\u00e9canisme mol\u00e9culaire de la pyroptose sur les unit\u00e9s neuronales vasculaires (constitu\u00e9es de microglies, d&#039;astrocytes, de neurones,\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les cellules endoth\u00e9liales vasculaires gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascular-endothelial-cell\">cellules endoth\u00e9liales vasculaires<\/a>, p\u00e9ricytes) apr\u00e8s IS. IRF\u00a0:\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le facteur de r\u00e9gulation de l\u2019interf\u00e9ron gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/interferon-regulatory-factor\">facteur r\u00e9gulateur de l&#039;interf\u00e9ron<\/a>; IFN\u00a0:\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019interf\u00e9ron gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/interferon\">Interf\u00e9ron<\/a>; CASP\u00a0: Caspase\u00a0; GPX4\u00a0: Glutathion peroxydase 4].<\/p>\n<\/figure>\n<\/div>\n<\/section>\n<\/section>\n<section id=\"sec0090\">\n<h2 id=\"sect0110\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">4. Potentiel des inhibiteurs de la pyroptose pour traiter l&#039;EI<\/h2>\n<p id=\"p0140\">Ces derni\u00e8res ann\u00e9es, la recherche sur les inhibiteurs de la pyroptose dans l\u2019EI a re\u00e7u beaucoup d\u2019attention. Liang et coll.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib188\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib188\"><span class=\"anchor-text\">[188]<\/span><\/a>\u00a0ont d\u00e9couvert que l&#039;inhibiteur de la caspase-1, le VX-765, peut r\u00e9duire la caspase-1, l&#039;ASC, le GSDMD et l&#039;IL-1\u03b2, tout en r\u00e9gulant positivement les niveaux de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les prot\u00e9ines \u00e0 jonction serr\u00e9e gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tight-junction-protein\">prot\u00e9ines \u00e0 jonction serr\u00e9e<\/a>\u00a0et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les inhibiteurs tissulaires des m\u00e9talloprot\u00e9inases gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/metalloprotease-inhibitor\">inhibiteurs tissulaires des m\u00e9talloprot\u00e9inases<\/a>, prot\u00e9geant l\u2019int\u00e9grit\u00e9 de la barri\u00e8re h\u00e9mato-enc\u00e9phalique. De plus, le VX-765 favorise \u00e9galement la transformation des microglies du type M1 au type M2, r\u00e9duit la r\u00e9ponse inflammatoire m\u00e9di\u00e9e par les microglies et exerce un effet neuroprotecteur.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib189\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib189\"><span class=\"anchor-text\">[189]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib190\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib190\"><span class=\"anchor-text\">[190]<\/span><\/a>. MCC950 est un inhibiteur s\u00e9lectif de NLRP3. Des \u00e9tudes ont montr\u00e9 que MCC950 peut r\u00e9duire l&#039;expression de NLRP3, Caspase-1 et IL-1\u03b2 dans la p\u00e9nombre isch\u00e9mique et a un effet protecteur sur l&#039;isch\u00e9mie c\u00e9r\u00e9brale focale chez la souris.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib191\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib191\"><span class=\"anchor-text\">[191]<\/span><\/a>. Des \u00e9tudes ont montr\u00e9 que certains\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les microARN gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microrna\">microARN<\/a>\u00a0peut inhiber la pyroptose dans le mod\u00e8le d&#039;isch\u00e9mie c\u00e9r\u00e9brale et jouer un r\u00f4le neuroprotecteur\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib192\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib192\"><span class=\"anchor-text\">[192]<\/span><\/a>. LP17 peut inhiber\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les cellules my\u00e9lo\u00efdes gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/myeloid-cell\">cellule my\u00e9lo\u00efde<\/a>\u00a0d\u00e9clencher le r\u00e9cepteur-1, inhibant ainsi le stress oxydatif et la pyroptose, et r\u00e9duisant les dommages neuronaux induits par l&#039;isch\u00e9mie c\u00e9r\u00e9brale\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib192\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib192\"><span class=\"anchor-text\">[192]<\/span><\/a>.\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019histidine gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/histidine\">Histidine<\/a>\u00a0peut inhiber la pyroptose m\u00e9di\u00e9e par NLRP3 en r\u00e9gulant la voie de signalisation prot\u00e9ine kinase\/glycog\u00e8ne synthase kinase-3\u03b2 activ\u00e9e par l&#039;ad\u00e9nylate, exer\u00e7ant ainsi des effets neuroprotecteurs anti-CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib193\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib193\"><span class=\"anchor-text\">[193]<\/span><\/a>. Les r\u00e9cepteurs des lipoprot\u00e9ines de basse densit\u00e9 peuvent inhiber la pyroptose neuronale m\u00e9di\u00e9e par NLRP3 apr\u00e8s CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib194\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib194\"><span class=\"anchor-text\">[194]<\/span><\/a>. L&#039;axe 1 de l&#039;\u03b1-glutamate oxaloac\u00e9tate transaminase 1 du r\u00e9cepteur activ\u00e9 par les prolif\u00e9rateurs de peroxysomes m\u00e9di\u00e9 par l&#039;alcool lipidique peut inhiber la pyroptose des cellules endoth\u00e9liales apr\u00e8s une IS et am\u00e9liorer les l\u00e9sions c\u00e9r\u00e9brales isch\u00e9miques\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib195\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib195\"><span class=\"anchor-text\">[195]<\/span><\/a>. La surexpression de CHRFAM7A peut inhiber la pyroptose microgliale d\u00e9pendante de la voie NLRP3\/caspase-1 et att\u00e9nuer le CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib196\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib196\"><span class=\"anchor-text\">[196]<\/span><\/a>. Les r\u00e9gulateurs de la glycolyse et de l&#039;apoptose induits par TP53 peuvent att\u00e9nuer la pyroptose microgliale induite par l&#039;isch\u00e9mie c\u00e9r\u00e9brale et les l\u00e9sions c\u00e9r\u00e9brales isch\u00e9miques\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib197\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib197\"><span class=\"anchor-text\">[197]<\/span><\/a>. En outre,\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les exosomes gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/exosome\">exosomes<\/a>\u00a0d\u00e9riv\u00e9 de la moelle osseuse hypoxique\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les cellules souches m\u00e9senchymateuses gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mesenchymal-stem-cell\">Les cellules souches m\u00e9senchymateuses<\/a>\u00a0peut moduler le ph\u00e9notype microglial M1\/M2 pour att\u00e9nuer la pyroptose neuronale induite par le CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib198\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib198\"><span class=\"anchor-text\">[198]<\/span><\/a>. Hypoxie pr\u00e9conditionn\u00e9e\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la muqueuse olfactive gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/olfactory-mucosa\">muqueuse olfactive<\/a>\u00a0les cellules souches m\u00e9senchymateuses peuvent inhiber la pyroptose et l&#039;apoptose des microglies caus\u00e9es par l&#039;isch\u00e9mie c\u00e9r\u00e9brale en activant le facteur 1\u03b1 inductible par l&#039;hypoxie, r\u00e9duisant ainsi le CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib199\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib199\"><span class=\"anchor-text\">[199]<\/span><\/a>.<\/p>\n<p id=\"p0145\">En tant qu&#039;ex\u00e9cuteur de la pyroptose, le GSDMD est une cible mol\u00e9culaire id\u00e9ale pour le traitement de l&#039;IS. Cependant, les recherches actuelles sur les inhibiteurs de la GSDMD en sont encore \u00e0 leurs balbutiements et les preuves de l\u2019efficacit\u00e9 des inhibiteurs de la GSDMD dans le traitement des accidents vasculaires c\u00e9r\u00e9braux isch\u00e9miques font d\u00e9faut. Des \u00e9tudes r\u00e9centes ont montr\u00e9 que certains composants naturels des plantes peuvent traiter l&#039;EI en r\u00e9gulant la voie pyroptotique.<\/p>\n<\/section>\n<section id=\"sec0095\">\n<h2 id=\"sect0115\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">5. Produits naturels comme nouveaux inhibiteurs de la pyroptose et deviennent ainsi des candidats potentiels pour le traitement de l&#039;IS<\/h2>\n<p id=\"p0150\">Les produits naturels pr\u00e9sentent des avantages significatifs dans la pr\u00e9vention et le traitement de l&#039;infarctus c\u00e9r\u00e9bral\/de l&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale en raison de leurs avantages de multi-composants, multi-cibles, multicanaux et de faible toxicit\u00e9, et ont de bonnes perspectives d&#039;application. Actuellement, la recherche de produits naturels dans la pr\u00e9vention et le traitement de l&#039;infarctus c\u00e9r\u00e9bral\/CIRI augmente progressivement, impliquant une vari\u00e9t\u00e9 de m\u00e9canismes de protection. Cette section r\u00e9sume les produits naturels, les mod\u00e8les animaux ou cellulaires, les m\u00e9thodes d&#039;administration, les doses d&#039;administration, la dur\u00e9e du traitement, les effets et les m\u00e9canismes de traitement (voies de signalisation) pour fournir un soutien th\u00e9orique \u00e0 la recherche rapide de composants v\u00e9g\u00e9taux naturels s\u00fbrs, efficaces et \u00e0 faible toxicit\u00e9. , et r\u00e9gulent la pyroptose pour la pr\u00e9vention et le traitement de l&#039;IS\/CIRI.<\/p>\n<section id=\"sec0100\">\n<h3 id=\"sect0120\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">5.1. Composants v\u00e9g\u00e9taux naturels<\/h3>\n<div>\n<p id=\"p0155\">La structure principale des composants naturels des plantes a \u00e9t\u00e9 pr\u00e9sent\u00e9e dans\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#fig0015\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"fig0015\"><span class=\"anchor-text\">Figure 3<\/span><\/a>.<\/p>\n<figure id=\"fig0015\" class=\"figure text-xs\"><img decoding=\"async\" src=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr3.jpg\" alt=\"Fig. 3\" height=\"397\" aria-describedby=\"cap0015\" \/><\/p>\n<ol class=\"u-margin-s-bottom\">\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"T\u00e9l\u00e9charger l&#039;image haute r\u00e9solution (208 Ko)\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr3_lrg.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">T\u00e9l\u00e9charger :\u00a0<span class=\"download-link-title\">T\u00e9l\u00e9charger l&#039;image haute r\u00e9solution (208 Ko)<\/span><\/span><\/a><\/li>\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"T\u00e9l\u00e9charger l&#039;image en taille r\u00e9elle\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr3.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">T\u00e9l\u00e9charger :\u00a0<span class=\"download-link-title\">T\u00e9l\u00e9charger l&#039;image en taille r\u00e9elle<\/span><\/span><\/a><\/li>\n<\/ol>\n<p id=\"sp0015\"><span class=\"label\">Figure 3<\/span>. La structure principale des composants v\u00e9g\u00e9taux naturels.<\/p>\n<\/figure>\n<\/div>\n<section id=\"sec0105\">\n<h4 id=\"sect0125\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.1. Gastrodine (GAZ)<\/h4>\n<p id=\"p0160\">Le GAZ est un compos\u00e9 multifonctionnel d\u00e9riv\u00e9 de l&#039;herbe,\u00a0<em><a class=\"topic-link\" title=\"Apprenez-en davantage sur Gastrodia elata gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/gastrodia-elata\">Gastrodia elata<\/a><\/em>, avec divers\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les activit\u00e9s pharmacologiques gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/pharmacological-activity\">activit\u00e9s pharmacologiques<\/a>, telles que les activit\u00e9s antioxydantes et anti-inflammatoires. De plus, il a \u00e9t\u00e9 d\u00e9montr\u00e9 que le SGA r\u00e9duit consid\u00e9rablement les sympt\u00f4mes d\u2019isch\u00e9mie-reperfusion c\u00e9r\u00e9brale en modulant les facteurs pro-apoptotiques, notamment le clivage de la caspase-3, l\u2019IL-18 et l\u2019IL-1\u03b2. Plusieurs \u00e9tudes ont montr\u00e9 que le SGA att\u00e9nue les l\u00e9sions isch\u00e9miques c\u00e9r\u00e9brales et r\u00e9duit les niveaux de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les esp\u00e8ces r\u00e9actives de l\u2019oxyg\u00e8ne gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/reactive-oxygen-species\">les esp\u00e8ces r\u00e9actives de l&#039;oxyg\u00e8ne<\/a>\u00a0et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les cytokines inflammatoires gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammatory-cytokine\">cytokines inflammatoires<\/a>\u00a0Chez la souris\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib200\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib200\"><span class=\"anchor-text\">[200]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib201\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib201\"><span class=\"anchor-text\">[201]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib202\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib202\"><span class=\"anchor-text\">[202]<\/span><\/a>. Lu et coll. ont d\u00e9couvert que le SGA pouvait am\u00e9liorer la pyroptose associ\u00e9e aux l\u00e9sions d&#039;isch\u00e9mie-reperfusion microvasculaire cardiaque en ciblant l&#039;axe NLRP3\/caspase-1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib203\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib203\"><span class=\"anchor-text\">[203]<\/span><\/a>. Le GAZ peut am\u00e9liorer consid\u00e9rablement la\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la fonction neurologique gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nervous-system-physiology\">fonction neurologique<\/a>\u00a0marquer et r\u00e9duire la taille de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019infarctus c\u00e9r\u00e9bral gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-infarction\">infarctus c\u00e9r\u00e9bral<\/a>. Pendant ce temps, le GAS a inhib\u00e9 la pyroptose en r\u00e9gulant \u00e0 la baisse le NLRP3, les facteurs inflammatoires (IL-1\u03b2, IL-18) et la caspase-1 cliv\u00e9e. De plus, le GAS a att\u00e9nu\u00e9 l&#039;inflammation des cellules neuronales induite par l&#039;isch\u00e9mie-reperfusion en r\u00e9gulant l&#039;axe lncRNA NEAT1\/miR-22-3p. Le GAS a att\u00e9nu\u00e9 de mani\u00e8re significative les l\u00e9sions d&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale en r\u00e9gulant l&#039;axe lncRNA NEAT1\/miR-22-3p\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib204\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib204\"><span class=\"anchor-text\">[204]<\/span><\/a>. Par cons\u00e9quent, le GAZ peut \u00eatre utilis\u00e9 comme potentiel\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les m\u00e9dicaments gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chemotherapeutic-agent\">m\u00e9dicament<\/a>\u00a0pour le traitement du CIRI.<\/p>\n<\/section>\n<section id=\"sec0110\">\n<h4 id=\"sect0130\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.2. Tanshinone IIA<\/h4>\n<p id=\"p0165\"><a class=\"topic-link\" title=\"Apprenez-en davantage sur Tanshinone IIA gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tanshinone-iia\">Tanshinone IIA<\/a>\u00a0est le principal composant actif de\u00a0<em><a class=\"topic-link\" title=\"Apprenez-en davantage sur Salvia miltiorrhiza gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/salvia-miltiorrhiza\">Salvia miltiorrhiza<\/a><\/em>. Il est largement utilis\u00e9 dans le traitement des maladies cardiovasculaires et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les maladies c\u00e9r\u00e9brovasculaires gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebrovascular-disease\">maladies c\u00e9r\u00e9brovasculaires<\/a>\u00a0en raison de ses effets antioxydants et am\u00e9liorant la circulation. Cai et coll.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib205\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib205\"><span class=\"anchor-text\">[205]<\/span><\/a>\u00a0ont d\u00e9couvert que la tanshinone IIA r\u00e9duisait efficacement l&#039;expression de l&#039;IL-1\u03b2 et de l&#039;IL-18 dans la voie de signalisation inflammatoire NLRP3 et que son effet \u00e9tait dose-d\u00e9pendant. Ceci sugg\u00e8re que la tanshinone IIA inhibe l&#039;activation de la voie de signalisation NLRP3, r\u00e9duisant ainsi les dommages caus\u00e9s par la privation\/reperfusion d&#039;oxyg\u00e8ne-glucose sur les cellules BV-2 apr\u00e8s un accident vasculaire c\u00e9r\u00e9bral.<\/p>\n<\/section>\n<section id=\"sec0115\">\n<h4 id=\"sect0135\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.3. L\u00e9onurine<\/h4>\n<p id=\"p0170\"><a class=\"topic-link\" title=\"Apprenez-en davantage sur L\u00e9onurine gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/leonurine\">L\u00e9onurine<\/a>\u00a0dans\u00a0<em><a class=\"topic-link\" title=\"Apprenez-en davantage sur Leonuri gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/leonurus\">L\u00e9onuri<\/a><\/em><em>\u00a0herbe<\/em>\u00a0am\u00e9lior\u00e9 la capacit\u00e9 d&#039;apprentissage et la capacit\u00e9 de m\u00e9moire des rats atteints d&#039;isch\u00e9mie c\u00e9r\u00e9brale chronique et r\u00e9duit l&#039;expression de NLRP3. On suppose que l\u2019objectif de protection des nerfs pourrait \u00eatre atteint gr\u00e2ce \u00e0 un effet anti-inflammatoire. L&#039;activation de NLRP3 a favoris\u00e9 la conversion du pr\u00e9curseur de la Caspase-1 en Caspase-1 et a favoris\u00e9 la production d&#039;IL-1\u03b2 et d&#039;IL-18, provoquant ainsi une s\u00e9rie de r\u00e9ponses inflammatoires. La l\u00e9onurine peut r\u00e9duire la r\u00e9ponse inflammatoire dans les tissus c\u00e9r\u00e9braux, r\u00e9duire le score de d\u00e9ficit neurologique en inhibant la pyroptose des cellules et avoir un bon effet neuroprotecteur.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib206\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib206\"><span class=\"anchor-text\">[206]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0120\">\n<h4 id=\"sect0140\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.4. Pa\u00e9oniflorine<\/h4>\n<p id=\"p0175\"><a class=\"topic-link\" title=\"Apprenez-en davantage sur la pa\u00e9oniflorine sur les pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/paeoniflorin\">Pa\u00e9oniflorine<\/a>\u00a0provient du composant principal de\u00a0<em><a class=\"topic-link\" title=\"Apprenez-en davantage sur Paeoniae radix rubra gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/radix-paeoniae-rubra\">Paeoniae radix rubra<\/a><\/em>. La pa\u00e9oniflorine est le principal composant actif des glucosides totaux de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la pivoine gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/paeonia\">pivoine<\/a>\u00a0(TGP), qui poss\u00e8de \u00e9galement de bonnes activit\u00e9s anti-inflammatoires et immunomodulatrices\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib207\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib207\"><span class=\"anchor-text\">[207]<\/span><\/a>. Le TGP et la pa\u00e9oniflorine ont \u00e9galement diverses activit\u00e9s pharmacologiques telles que\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les antispasmodiques gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antispasmodic\">antispasmodique<\/a>,\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les analg\u00e9siques gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/anodyne\">analg\u00e9sique<\/a>, et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la vasodilatation gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vasodilatation\">vasodilatation<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib208\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib208\"><span class=\"anchor-text\">[208]<\/span><\/a>. Zulifiya Ekemu et coll. ont d\u00e9couvert qu&#039;apr\u00e8s une isch\u00e9mie-reperfusion c\u00e9r\u00e9brale aigu\u00eb, l&#039;activation des microglies et de la pyroptose neuronale dans le cerveau \u00e9tait \u00e9vidente, l&#039;activation de NLRP3 \u00e9tait augment\u00e9e et la caspase-1 et l&#039;IL-1\u03b2 \u00e9taient r\u00e9gul\u00e9es positivement.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib209\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib209\"><span class=\"anchor-text\">[209]<\/span><\/a>. La pa\u00e9oniflorine a r\u00e9duit significativement les scores de la fonction neurologique, significativement r\u00e9duits\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la taille de l\u2019infarctus c\u00e9r\u00e9bral gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-infarction-size\">taille de l&#039;infarctus c\u00e9r\u00e9bral<\/a>, une expression de Iba1 consid\u00e9rablement r\u00e9gul\u00e9e \u00e0 la baisse et un \u00e9tat neuronal consid\u00e9rablement am\u00e9lior\u00e9. De plus, les expressions de NLRP3, Caspase-1 et IL-1\u03b2 ont \u00e9t\u00e9 significativement diminu\u00e9es apr\u00e8s l&#039;intervention de la pa\u00e9oniflorine. Il est sugg\u00e9r\u00e9 que la pa\u00e9oniflorine pourrait r\u00e9duire l&#039;activation des microglies, inhiber la pyroptose des neurones et am\u00e9liorer les dommages neurologiques m\u00e9di\u00e9s par l&#039;ACI en inhibant l&#039;activation de NLRP3 et de la Caspase-1.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib209\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib209\"><span class=\"anchor-text\">[209]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0125\">\n<h4 id=\"sect0145\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.5. Butylphtalide<\/h4>\n<p id=\"p0180\"><span class=\"small-caps\">L<\/span>Le -butylphtalide a \u00e9t\u00e9 isol\u00e9 pour la premi\u00e8re fois \u00e0 partir de graines de cresson, puis a pu \u00eatre synth\u00e9tis\u00e9 artificiellement.\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le butylphtalide gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/butylphthalide\">Butylphtalide<\/a>\u00a0a un double r\u00f4le unique, qui peut non seulement reconstruire\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la microcirculation gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microcirculation\">microcirculation<\/a>\u00a0et augmenter la reperfusion de l&#039;isch\u00e9mie, prot\u00e9geant ainsi l&#039;int\u00e9grit\u00e9 de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la structure vasculaire gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/blood-vessel\">structure vasculaire<\/a>, r\u00e9tablissant le diam\u00e8tre vasculaire, augmentant le flux sanguin dans la zone isch\u00e9mique et le nombre de cellules environnantes\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les microvaisseaux gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microvessel\">microvaisseaux<\/a>, mais \u00e9galement en prot\u00e9geant les mitochondries et en r\u00e9duisant la mort cellulaire, prot\u00e9geant ainsi l&#039;int\u00e9grit\u00e9 de la structure mitochondriale, am\u00e9liorant l&#039;activit\u00e9 de l&#039;enzyme complexe mitochondriale IV, am\u00e9liorant l&#039;activit\u00e9 de l&#039;enzyme ATP mitochondriale et maintenant la stabilit\u00e9 de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la membrane mitochondriale gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitochondrial-membrane\">membrane mitochondriale<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib210\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib210\"><span class=\"anchor-text\">[210]<\/span><\/a>. La derni\u00e8re \u00e9tude montre que le butylphtalide peut affecter la pyroptose chez les rats CIRI de mani\u00e8re dose-d\u00e9pendante via la voie de signalisation de l&#039;inflammasome NLRP3.<\/p>\n<\/section>\n<section id=\"sec0130\">\n<h4 id=\"sect0150\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.6. Br\u00e9viscapine<\/h4>\n<p id=\"p0185\"><a class=\"topic-link\" title=\"Apprenez-en davantage sur la Breviscapine gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/breviscapine\">Br\u00e9viscapine<\/a>\u00a0est extrait de\u00a0<em><a class=\"topic-link\" title=\"Apprenez-en davantage sur Erigeron breviscapus gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/erigeron-breviscapus\">Erigeron breviscapus<\/a><\/em>\u00a0(Vant.) Main. -Mazz. La br\u00e9viscapine est un m\u00e9lange de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la scutellarine gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/scutellarin\">scutellarine<\/a>\u00a0contenant principalement de la scutellarine avec une petite quantit\u00e9 de scutellarine, qui a pour fonction de dilater les vaisseaux sanguins c\u00e9r\u00e9braux, de r\u00e9duire la r\u00e9sistance c\u00e9r\u00e9brovasculaire, d&#039;augmenter le flux sanguin c\u00e9r\u00e9bral, d&#039;am\u00e9liorer la microcirculation et de r\u00e9sister\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019agr\u00e9gation plaquettaire gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/thrombocyte-aggregation\">agr\u00e9gation plaquettaire<\/a>. Les derni\u00e8res recherches montrent que la breviscapine a inhib\u00e9 de mani\u00e8re significative l&#039;activation des cellules inflammatoires NLRP3 dans le\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019hippocampe gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hippocampus\">hippocampe<\/a>\u00a0des rats CCI, r\u00e9gulent n\u00e9gativement l&#039;expression des prot\u00e9ines Caspase 1, IL-6 et IL-1\u03b2, inhibent l&#039;activation de la prot\u00e9ine Caspase-3 et inhibent\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019apoptose neuronale gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroapoptosis\">apoptose neuronale<\/a>. Ceci sugg\u00e8re que la breviscapine pourrait am\u00e9liorer consid\u00e9rablement la fonction cognitive des rats CCI et r\u00e9duire les dommages pathologiques des neurones isch\u00e9miques, et que son m\u00e9canisme pourrait \u00eatre li\u00e9 \u00e0 l&#039;inhibition de l&#039;activation de l&#039;inflammasome NLRP3 et de la voie de la pyroptose dans le tissu c\u00e9r\u00e9bral.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib211\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib211\"><span class=\"anchor-text\">[211]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0135\">\n<h4 id=\"sect0155\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.7. Resv\u00e9ratrol<\/h4>\n<p id=\"p0190\"><a class=\"topic-link\" title=\"Apprenez-en davantage sur le resv\u00e9ratrol gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/resveratrol\">Resv\u00e9ratrol<\/a>\u00a0est un non-flavono\u00efde\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les compos\u00e9s polyph\u00e9noliques gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/polyphenol-derivative\">compos\u00e9 polyph\u00e9nolique<\/a>. Il a d&#039;abord \u00e9t\u00e9 isol\u00e9 des racines de\u00a0<em><a class=\"topic-link\" title=\"Apprenez-en davantage sur Veratrum gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/veratrum\">V\u00e9ratrum<\/a><\/em><em>\u00a0grandiflorum<\/em>, et le resv\u00e9ratrol a \u00e9t\u00e9 trouv\u00e9 dans plus de 700 plantes. Des \u00e9tudes ont montr\u00e9 que le resv\u00e9ratrol joue un r\u00f4le important dans la r\u00e9gulation du stress oxydatif en cas d&#039;infarctus c\u00e9r\u00e9bral, en inhibant l&#039;inflammation et en am\u00e9liorant le cerveau.\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la neuroprotection gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroprotection\">neuroprotection<\/a>. Le resv\u00e9ratrol r\u00e9gule la pyroptose du tissu c\u00e9r\u00e9bral d&#039;isch\u00e9mie-reperfusion principalement par la r\u00e9gulation de l&#039;inflammasome des microglies NLRP3, de la Caspase-1 et de ZO-1.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib212\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib212\"><span class=\"anchor-text\">[212]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0140\">\n<h4 id=\"sect0160\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.8. Acide salvianolique (SAFI)<\/h4>\n<p id=\"p0195\">Des \u00e9tudes r\u00e9centes ont montr\u00e9 que le SAFI augmentait significativement les scores de d\u00e9ficit neurologique, r\u00e9duisait le volume de l&#039;infarctus, att\u00e9nuait les dommages histologiques\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le cortex c\u00e9r\u00e9bral gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebral-cortex\">cortex c\u00e9r\u00e9bral<\/a>\u00a0et l&#039;apoptose neuronale dans le mod\u00e8le MCAO\/R, augmentent la viabilit\u00e9 neuronale et r\u00e9duisent l&#039;apoptose neuronale dans le mod\u00e8le OGD. SAFI a \u00e9galement remodel\u00e9 le mod\u00e8le de polarisation microgliale d&#039;un ph\u00e9notype de type M1 \u00e0 un ph\u00e9notype de type M2 et a inhib\u00e9 l&#039;activation de l&#039;inflammasome NLRP3 et l&#039;expression des prot\u00e9ines li\u00e9es \u00e0 l&#039;inflammasome\/pyroxie NLRP3 in vitro et in vivo. Ceci sugg\u00e8re que SAFI pourrait exercer des effets neuroprotecteurs en r\u00e9duisant l&#039;apoptose neuronale, en d\u00e9pla\u00e7ant le ph\u00e9notype microglial de M1 \u00e0 M2 et en inhibant l&#039;axe inflammatoire\/pyroptotique NLRP3 dans la microglie.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib213\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib213\"><span class=\"anchor-text\">[213]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0145\">\n<h4 id=\"sect0165\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.9. Hispiduline<\/h4>\n<p id=\"p0200\"><a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019hispiduline gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hispidulin\">Hispiduline<\/a>\u00a0est un\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les flavono\u00efdes gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/flavonoid\">flavono\u00efde<\/a>\u00a0compos\u00e9 dot\u00e9 de diverses propri\u00e9t\u00e9s pharmacologiques et constitue l\u2019un des principaux composants actifs de nombreux\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les plantes m\u00e9dicinales chinoises gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect.\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chinese-herbal-medicine\">Plantes m\u00e9dicinales chinoises<\/a>. L&#039;hispiduline poss\u00e8de un large \u00e9ventail de propri\u00e9t\u00e9s pharmacologiques, notamment antioxydantes,\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les antifongiques gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antifungal-agent\">antifongique<\/a>,\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les antin\u00e9oplasiques gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/anticarcinogen\">antin\u00e9oplasique<\/a>, propri\u00e9t\u00e9s antiost\u00e9oporotiques, antiinflammatoires et antimutag\u00e8nes. La derni\u00e8re \u00e9tude a montr\u00e9 que l&#039;Hispidulin a am\u00e9lior\u00e9\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les sympt\u00f4mes neurologiques gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neurologic-disease\">sympt\u00f4mes neurologiques<\/a>\u00a0chez les rats apr\u00e8s IRI, tout en r\u00e9duisant la taille de l&#039;infarctus et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019\u0153d\u00e8me c\u00e9r\u00e9bral gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-edema\">\u0153d\u00e8me c\u00e9r\u00e9bral<\/a>. M\u00e9caniquement, l&#039;hispiduline exerce ses effets neuroprotecteurs in vivo et in vitro en inhibant la pyroptose m\u00e9di\u00e9e par NLRP3 en r\u00e9gulant la voie de signalisation AMPK\/GSK3\u03b2\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib214\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib214\"><span class=\"anchor-text\">[214]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0150\">\n<h4 id=\"sect0170\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.10. Astragaloside IV<\/h4>\n<p id=\"p0205\"><em><a class=\"topic-link\" title=\"Apprenez-en davantage sur Astragali Radix gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/astragalus-root\">Base d&#039;astragale<\/a><\/em>\u00a0peut compl\u00e9ter la carence, renforcer la rate et l&#039;estomac, favoriser la circulation sanguine et favoriser la circulation sanguine, et peut traiter les sympt\u00f4mes de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le d\u00e9ficit en Qi gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/qi-deficiency\">Carence en Qi<\/a>\u00a0et carence en sang\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib215\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib215\"><span class=\"anchor-text\">[215]<\/span><\/a>.\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019astragaloside IV gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/astragaloside-iv\">Astragaloside IV<\/a>\u00a0est l\u2019un des principaux composants actifs de\u00a0<em>Base d&#039;astragale<\/em>\u00a0et le\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le monom\u00e8re gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/monomer\">monom\u00e8re<\/a>\u00a0composant de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019astragale gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/astragalus\">Astragale<\/a>\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les saponines gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/saponin\">saponines<\/a>. Il est souvent utilis\u00e9 comme norme pour tester la qualit\u00e9 de l\u2019astragale.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib216\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib216\"><span class=\"anchor-text\">[216]<\/span><\/a>. L&#039;astragaloside IV poss\u00e8de une vari\u00e9t\u00e9 de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les activit\u00e9s biologiques gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/biological-activity\">activit\u00e9s biologiques<\/a>, et la port\u00e9e de la recherche implique plusieurs organes et tissus tels que le cerveau, le foie, le c\u0153ur, les poumons, les reins, l&#039;estomac, l&#039;intestin, les vaisseaux sanguins, etc.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib217\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib217\"><span class=\"anchor-text\">[217]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib218\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib218\"><span class=\"anchor-text\">[218]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib219\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib219\"><span class=\"anchor-text\">[219]<\/span><\/a>\u00a0Il a des activit\u00e9s biologiques telles que anti-inflammatoires, anti-virus, anti-apoptose, favorisant\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la prolif\u00e9ration cellulaire gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-proliferation\">proliferation cellulaire<\/a>, r\u00e9gulant\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la maladie du lapin gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/rabbit-disease\">maladie du lapin<\/a>, r\u00e9gulant la glyc\u00e9mie, ralentissant le vieillissement et inhibant le cancer\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib217\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib217\"><span class=\"anchor-text\">[217]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib218\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib218\"><span class=\"anchor-text\">[218]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib219\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib219\"><span class=\"anchor-text\">[219]<\/span><\/a>. Notre \u00e9tude pr\u00e9c\u00e9dente a identifi\u00e9 l&#039;astragaloside IV comme un agent neuroprotecteur potentiel jouant un r\u00f4le important dans le traitement de l&#039;IS. Par exemple, il peut prot\u00e9ger la barri\u00e8re h\u00e9mato-enc\u00e9phalique, am\u00e9liorer le m\u00e9tabolisme \u00e9nerg\u00e9tique, inhiber l&#039;apoptose des cellules nerveuses, inhiber la r\u00e9ponse inflammatoire, le stress oxydatif et exercer des effets neuroprotecteurs, am\u00e9liorant ainsi l&#039;isch\u00e9mie c\u00e9r\u00e9brale.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib220\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib220\"><span class=\"anchor-text\">[220]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib221\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib221\"><span class=\"anchor-text\">[221]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib222\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib222\"><span class=\"anchor-text\">[222]<\/span><\/a>. En termes de pyroptose, Tang et al. ont d\u00e9couvert que l&#039;inflammasome NLRP3 \u00e9tait activ\u00e9 pendant l&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale chez le rat, et que l&#039;inhibition de l&#039;inflammasome NLRP3 ou l&#039;inhibition de sa caspase-1 en aval pourrait att\u00e9nuer les dommages caus\u00e9s par l&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale chez le rat.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib223\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib223\"><span class=\"anchor-text\">[223]<\/span><\/a>. L&#039;astragaloside IV peut r\u00e9duire le score de d\u00e9ficit neurologique, r\u00e9duire le volume de l&#039;infarctus c\u00e9r\u00e9bral et r\u00e9duire les niveaux de prot\u00e9ines NLRP3, Caspase-1, pro-IL-1\u03b2, IL-1\u03b2, pro-IL-18 et IL-18 dans le tissu c\u00e9r\u00e9bral. , et inhibent l&#039;expression de la prot\u00e9ine NF-\u03baB phosphoryl\u00e9e. Ceci sugg\u00e8re que l&#039;astragaloside IV a un effet anti-CIRI et que son m\u00e9canisme pourrait \u00eatre li\u00e9 \u00e0 l&#039;inhibition du NF-\u03baB.\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la phosphorylation des prot\u00e9ines gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/protein-phosphorylation\">phosphorylation des prot\u00e9ines<\/a>\u00a0et l&#039;inhibition de l&#039;activation de l&#039;inflammasome NLRP3\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib223\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib223\"><span class=\"anchor-text\">[223]<\/span><\/a>. Li et coll. a \u00e9galement d\u00e9couvert que l&#039;astragaloside IV peut r\u00e9duire les l\u00e9sions c\u00e9r\u00e9brales induites par l&#039;hypoxie-isch\u00e9mie chez les rats nouveau-n\u00e9s et inhiber la r\u00e9ponse inflammatoire du tissu c\u00e9r\u00e9bral hypoxique-isch\u00e9mique et des neurones hippocampiques HT22 chez les rats nouveau-n\u00e9s, qui peut \u00eatre exerc\u00e9e en r\u00e9gulant NLRP3\/ m\u00e9di\u00e9e par MMP-9. Voie de signalisation de la caspase-1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib224\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib224\"><span class=\"anchor-text\">[224]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0155\">\n<h4 id=\"sect0175\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.11. Saponines de Panax notoginseng (PNS)<\/h4>\n<p id=\"p0210\"><em>Notoginseng Radix Et Rhizome<\/em>\u00a0est la racine s\u00e9ch\u00e9e et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le rhizome gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/rhizome\">rhizome<\/a>\u00a0de\u00a0<em><a class=\"topic-link\" title=\"Apprenez-en davantage sur Panax gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/panax\">Panax<\/a><\/em><em>\u00a0notoginsen (Burk.)<\/em>\u00a0FH Chen, qui a une activit\u00e9 pharmacologique sur les syst\u00e8mes sanguin, cardiovasculaire, nerveux et immunitaire\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib225\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib225\"><span class=\"anchor-text\">[225]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib226\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib226\"><span class=\"anchor-text\">[226]<\/span><\/a>. Le PNS est son principal ingr\u00e9dient actif, contenant une vari\u00e9t\u00e9 de saponines monom\u00e8res, et ses pr\u00e9parations telles que l&#039;injection de Xuesaitong sont largement utilis\u00e9es dans la pr\u00e9vention et le traitement des maladies cardiovasculaires et c\u00e9r\u00e9brovasculaires.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib227\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib227\"><span class=\"anchor-text\">[227]<\/span><\/a>. Nos \u00e9tudes pr\u00e9c\u00e9dentes et les \u00e9tudes existantes ont montr\u00e9 que le SNP a divers effets pharmacologiques dans les l\u00e9sions c\u00e9r\u00e9brales isch\u00e9miques, telles que\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les antithrombotiques gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antithrombotic\">antithrombotique<\/a>, anti-inflammatoire, antioxydant, inhibant l&#039;apoptose des cellules nerveuses c\u00e9r\u00e9brales et am\u00e9liorant les dommages \u00e0 la barri\u00e8re h\u00e9mato-enc\u00e9phalique\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib228\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib228\"><span class=\"anchor-text\">[228]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib229\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib229\"><span class=\"anchor-text\">[229]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib230\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib230\"><span class=\"anchor-text\">[230]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib231\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib231\"><span class=\"anchor-text\">[231]<\/span><\/a>. Ceci sugg\u00e8re que le PNS pourrait jouer un r\u00f4le protecteur dans l&#039;isch\u00e9mie c\u00e9r\u00e9brale \u00e0 travers de multiples cibles. Des \u00e9tudes r\u00e9centes ont montr\u00e9 que le SNP peut inhiber l&#039;activation de l&#039;inflammasome NLRP3 et favoriser s\u00e9lectivement\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la mitophagie gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitophagy\">mitophagie<\/a>\u00a0lors d&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale chez le rat. L&#039;inhibition de la mitophagie pourrait inverser l&#039;effet inhibiteur du PNS sur l&#039;inflammasome NLRP3, indiquant que la mitophagie m\u00e9die l&#039;effet inhibiteur du PNS sur l&#039;activation de l&#039;inflammasome NLRP3 dans l&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale. De plus, les niveaux de prot\u00e9ines PINK1 et Parkin dans les mitochondries ont augment\u00e9 au cours de l&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale chez le rat, et le SNP pourrait encore augmenter les niveaux de prot\u00e9ines PINK1 et Parkin dans les mitochondries du tissu c\u00e9r\u00e9bral. Ceci sugg\u00e8re que le SNP pourrait favoriser la mitophagie dans l&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale via la voie PINK1\/Parkin.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib232\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib232\"><span class=\"anchor-text\">[232]<\/span><\/a>. En r\u00e9sum\u00e9, le PNS favorise s\u00e9lectivement la mitophagie via la voie PINK1\/Parkin, inhibe l&#039;activation de l&#039;inflammasome NLRP3 dans l&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale et att\u00e9nue les l\u00e9sions d&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale.<\/p>\n<\/section>\n<\/section>\n<section id=\"sec0160\">\n<h3 id=\"sect0180\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">5.2. Extrait naturel de plante<\/h3>\n<section id=\"sec0165\">\n<h4 id=\"sect0185\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.1. D\u00e9coction Taohong Siwu (THSWD)<\/h4>\n<p id=\"p0215\">Le THSWD est l&#039;une des prescriptions classiques pour favoriser la circulation sanguine et \u00e9liminer\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la stase sanguine gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/blood-stasis\">stase du sang<\/a>, \u00e9liminant la stase du sang et r\u00e9g\u00e9n\u00e9rant le nouveau sang cr\u00e9\u00e9 par le \u00ab Miroir dor\u00e9 de la m\u00e9decine \u00bb de Wu Qian sous la dynastie Qing. Les \u00e9tudes pharmacologiques actuelles ont confirm\u00e9 que les principaux ingr\u00e9dients actifs du THSWD comprennent\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019acide f\u00e9rulique gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ferulic-acid\">acide f\u00e9rulique<\/a>,\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le carthame gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/safflower\">carthame<\/a>\u00a0jaune, et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les polysaccharides gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glycan\">polysaccharides<\/a>. Parmi eux, l&#039;acide f\u00e9rulique a des effets pharmacologiques tels que l&#039;inhibition de l&#039;agr\u00e9gation plaquettaire, antithrombotique, anti-inflammatoire et anti-oxydant. Le jaune de carthame a des effets anti-c\u00e9r\u00e9braux, anti-myocardiques, anti-thrombose, antioxydants, anti-tumoraux et autres. Zhou et coll. ont d\u00e9couvert que le THSWD am\u00e9liorait la fonction de d\u00e9ficit neurologique, le volume de l&#039;infarctus c\u00e9r\u00e9bral et la morphologie du tissu c\u00e9r\u00e9bral apr\u00e8s une l\u00e9sion d&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale, et r\u00e9duisait de mani\u00e8re significative les niveaux de prot\u00e9ines DRP1, NLRP3, Caspase-1 et IL-1 \u03b2\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib233\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib233\"><span class=\"anchor-text\">[233]<\/span><\/a>. Il a indiqu\u00e9 que l&#039;effet th\u00e9rapeutique du THSWD sur l&#039;infarctus c\u00e9r\u00e9bral \u00e9tait li\u00e9 \u00e0 l&#039;inhibition de la voie DRP1\/NLRP3 li\u00e9e \u00e0 la pyroptose. Des recherches plus approfondies ont montr\u00e9 que les contenus en IL-1\u03b2 et IL-18 dans le groupe THSWD \u00e9taient significativement diminu\u00e9s et que les niveaux de NLRP3, Caspase-1, Caspase-1 p10, ASC, TXNIP et GSDMD \u00e9taient diminu\u00e9s. La d\u00e9tection des voies de signalisation a montr\u00e9 que THSWD r\u00e9duisait significativement les niveaux d&#039;expression de HMGB1\/RAGE, TLR4\/NF-\u03baB,\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le MAPK p38 \u00e0 partir des pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/p38-mitogen-activated-protein-kinase\">p38 MAPK<\/a>\u00a0et JNK dans la p\u00e9nombre. En r\u00e9sum\u00e9, le THSWD a r\u00e9duit le niveau de r\u00e9ponse inflammatoire chez les rats MCAO\/R, inhibe l&#039;activation de l&#039;inflammasome NLRP3 chez les rats MCAO\/R et r\u00e9gule \u00e0 la baisse le GSDMD. THSWD a pour effet d&#039;inhiber la pyroptose, qui peut \u00eatre affect\u00e9e par l&#039;inhibition des voies de signalisation HMGB1\/TLR4\/NF-kB et MAPK\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib234\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib234\"><span class=\"anchor-text\">[234]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0170\">\n<h4 id=\"sect0190\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.2. G\u00e9lules Naoxinqing (NXQC)<\/h4>\n<p id=\"p0220\">Le principal ingr\u00e9dient de NXQC est la feuille de\u00a0<em><a class=\"topic-link\" title=\"Apprenez-en davantage sur Diospyros kaki gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/persimmon\">Diospyros kaki<\/a><\/em>\u00a0Thunb (feuille de kaki). Des \u00e9tudes ont montr\u00e9 que l&#039;extrait de feuille de kaki contient des flavono\u00efdes, des acides organiques et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la coumarine gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/coumarin\">coumarine<\/a>\u00a0et d&#039;autres produits chimiques, qui ont des effets anti-inflammatoires, antioxydants,\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les antihypertenseurs gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antihypertensive-agent\">antihypertenseur<\/a>, diminution des lipides sanguins, am\u00e9lioration\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les muscles lisses vasculaires gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascular-smooth-muscle\">muscle lisse vasculaire<\/a>\u00a0fonction et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019h\u00e9modynamique gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hemodynamic\">h\u00e9modynamique<\/a>\u00a0fonction. Le m\u00e9dicament a \u00e9t\u00e9 largement utilis\u00e9 dans le traitement des maladies cardiovasculaires et c\u00e9r\u00e9brovasculaires.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib235\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib235\"><span class=\"anchor-text\">[235]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib236\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib236\"><span class=\"anchor-text\">[236]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib237\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib237\"><span class=\"anchor-text\">[237]<\/span><\/a>. Les \u00e9tudes existantes ont montr\u00e9 que NXQC peut am\u00e9liorer efficacement\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019art\u00e9rioscl\u00e9rose c\u00e9r\u00e9brale gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebral-atherosclerosis\">art\u00e9rioscl\u00e9rose c\u00e9r\u00e9brale<\/a>\u00a0et prot\u00e9ger les l\u00e9sions nerveuses caus\u00e9es par l&#039;isch\u00e9mie c\u00e9r\u00e9brale\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib238\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib238\"><span class=\"anchor-text\">[238]<\/span><\/a>. Min et coll. a d\u00e9couvert que NXQC peut am\u00e9liorer efficacement le d\u00e9clin de la capacit\u00e9 d&#039;apprentissage apr\u00e8s une isch\u00e9mie c\u00e9r\u00e9brale et augmenter les activit\u00e9s de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la superoxyde dismutase gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/superoxide-dismutase\">superoxyde dismutase<\/a>\u00a0et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la lactate d\u00e9shydrog\u00e9nase gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/lactate-dehydrogenase\">lactate d\u00e9shydrog\u00e9nase<\/a>, augmenter la teneur en GSH et r\u00e9duire la teneur en\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le malondiald\u00e9hyde gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/malonaldehyde\">malondiald\u00e9hyde<\/a>. NXQC peut \u00e9galement r\u00e9guler n\u00e9gativement les prot\u00e9ines ASC, NLRP3 et Caspase-1 dans l&#039;hippocampe et r\u00e9duire consid\u00e9rablement les teneurs en IL-18 et IL-1\u03b2. Ils ont \u00e9galement constat\u00e9 que les cellules positives de la mol\u00e9cule d&#039;adh\u00e9sion des cellules endoth\u00e9liales plaquettaires-1 chez les gerbilles \u00e9taient significativement augment\u00e9es apr\u00e8s l&#039;intervention avec NXQC, et que\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les jonctions intercellulaires gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-junction\">jonctions intercellulaires<\/a>\u00a0\u00e9taient serr\u00e9s. Il est sugg\u00e9r\u00e9 que NXQC puisse prot\u00e9ger efficacement la morphologie des\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la r\u00e9gion CA1 de l\u2019hippocampe gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/sommers-sector\">r\u00e9gion hippocampique CA1<\/a>\u00a0des gerbilles, prot\u00e8gent la fonction c\u00e9r\u00e9brovasculaire, puis inhibent les l\u00e9sions d&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib239\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib239\"><span class=\"anchor-text\">[239]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0175\">\n<h4 id=\"sect0195\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.3. D\u00e9coction Buyang Huanwu (BYHWD) et ses modifications<\/h4>\n<p id=\"p0225\">BYHWD est un c\u00e9l\u00e8bre\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la m\u00e9decine traditionnelle chinoise gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/traditional-chinese-medicine\">M\u00e9decine Chinoise Traditionnelle<\/a>\u00a0formule utilis\u00e9e pour traiter les accidents vasculaires c\u00e9r\u00e9braux. Sa prescription a \u00e9t\u00e9 enregistr\u00e9e pour la premi\u00e8re fois dans la \u00ab Correction des classiques m\u00e9dicaux \u00bb de Wang Qingren sous la dynastie Qing.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib240\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib240\"><span class=\"anchor-text\">[240]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib241\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib241\"><span class=\"anchor-text\">[241]<\/span><\/a>. C&#039;est un repr\u00e9sentant exceptionnel de la prescription pour nourrir le qi et activer le sang. Il a pour fonctions de tonifier le qi, de favoriser la circulation sanguine et de drainer les collat\u00e9raux. Ses \u00e9tudes de m\u00e9decine fond\u00e9es sur des preuves ont montr\u00e9 de bons effets cliniques\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib242\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib242\"><span class=\"anchor-text\">[242]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib243\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib243\"><span class=\"anchor-text\">[243]<\/span><\/a>. Notre \u00e9tude pr\u00e9c\u00e9dente a montr\u00e9 que BYHWD\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les glycosides gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glycoside\">glycosides<\/a>\u00a0peut am\u00e9liorer le dysfonctionnement neurologique, r\u00e9duire les dommages neuronaux et inhiber la pyroptose neuronale. Les glycosides BYHWD sont les ingr\u00e9dients actifs extraits du BYHWD, comprenant principalement l&#039;astragaloside IV, la pa\u00e9oniflorine et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019amygdaline gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/amygdalin\">amygdaline<\/a>. C&#039;est le principal ingr\u00e9dient actif pharmacologique qui tonifie les reins et active le sang, et peut traiter les l\u00e9sions nerveuses isch\u00e9miques c\u00e9r\u00e9brales.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib244\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib244\"><span class=\"anchor-text\">[244]<\/span><\/a>. De plus, nous avons observ\u00e9 que les glycosides BYHWD inhibaient de mani\u00e8re significative l&#039;expression des prot\u00e9ines NLRP3, ASC, pro-caspase-1, caspase-1 et IL-1\u03b2 de la voie canonique de la pyroptose m\u00e9di\u00e9e par NLRP3.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib209\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib209\"><span class=\"anchor-text\">[209]<\/span><\/a>. En r\u00e9sum\u00e9, les glycosides BYHWD exercent des effets neuroprotecteurs en inhibant la pyroptose neuronale apr\u00e8s CIRI, ce qui est \u00e9troitement li\u00e9 \u00e0 la r\u00e9gulation de la voie pyroptotique classique par NLRP3. De plus, Longzhi\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la d\u00e9coction \u00e0 partir des pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/decoction\">D\u00e9coction<\/a>\u00a0est une formule empirique form\u00e9e par BYHWD avec des sangsues et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur Achyranthes gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/achyranthes\">Achyranthe<\/a>\u00a0sichuanensis. Il est utilis\u00e9 dans le traitement clinique des accidents vasculaires c\u00e9r\u00e9braux aigus depuis de nombreuses ann\u00e9es et son effet est tr\u00e8s bon.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib245\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib245\"><span class=\"anchor-text\">[245]<\/span><\/a>. Des \u00e9tudes r\u00e9centes ont montr\u00e9 que la d\u00e9coction de Longzhi a des effets \u00e9vidents sur l&#039;am\u00e9lioration des sympt\u00f4mes neurologiques chez les rats apr\u00e8s CIRI, le maintien de l&#039;\u00e9tat des cellules nerveuses dans le tissu c\u00e9r\u00e9bral et la r\u00e9duction du volume de l&#039;infarctus c\u00e9r\u00e9bral. En termes de pyroptose cellulaire interm\u00e9diaire, la d\u00e9coction de Longzhi peut am\u00e9liorer les sympt\u00f4mes des rats apr\u00e8s CIRI et prot\u00e9ger\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les l\u00e9sions des cellules nerveuses gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nerve-cell-lesion\">dommages aux cellules nerveuses<\/a>\u00a0apr\u00e8s une blessure en r\u00e9gulant \u00e0 la baisse l&#039;expression des prot\u00e9ines Caspase-1 et IL-18\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib245\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib245\"><span class=\"anchor-text\">[245]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0180\">\n<h4 id=\"sect0200\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.4. Ordonnance de Yiqi Huoxue (YQHXP)<\/h4>\n<p id=\"p0230\">YQHXP se compose de\u00a0<em>Base d&#039;Angelicae Sinensis, base d&#039;Astragali,\u00a0<\/em><em><a class=\"topic-link\" title=\"Apprenez-en davantage sur le rhizome de Chuanxiong gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ligusticum-chuanxiong-extract\">Rhizome de Chuanxiong<\/a><\/em><em>, Scorpion, Leonuri Herba, Acori Tatarinowii Rhizoma, Borneolum Syntheticum<\/em>, et a obtenu de bons r\u00e9sultats cliniques\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib246\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib246\"><span class=\"anchor-text\">[246]<\/span><\/a>. Des \u00e9tudes animales ont montr\u00e9 que YQHXP am\u00e9liorait les scores de fonction neurologique et les taux d&#039;infarctus c\u00e9r\u00e9bral chez le rat, et r\u00e9duisait les niveaux d&#039;IL-1\u03b2, de TNF-\u03b1 et d&#039;IL-18 dans les tissus c\u00e9r\u00e9braux, ainsi que l&#039;expression relative de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur P2RX7 gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/p2rx7\">P2RX7<\/a>, Caspase-1, Caspase-11 et GSDMD dans le tissu de p\u00e9nombre isch\u00e9mique c\u00e9r\u00e9bral. Apr\u00e8s l&#039;intervention YQHXP, l&#039;exsudation inflammatoire et l&#039;\u0153d\u00e8me du tissu c\u00e9r\u00e9bral ont \u00e9t\u00e9 consid\u00e9rablement r\u00e9duits, et la morphologie cellulaire et la d\u00e9g\u00e9n\u00e9rescence vacuolaire neuronale ont \u00e9t\u00e9 am\u00e9lior\u00e9es. En r\u00e9sum\u00e9, le YQHXP peut r\u00e9duire l&#039;inflammation des tissus c\u00e9r\u00e9braux chez les rats victimes d&#039;un accident vasculaire c\u00e9r\u00e9bral isch\u00e9mique aigu en inhibant la pyroptose.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib247\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib247\"><span class=\"anchor-text\">[247]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0185\">\n<h4 id=\"sect0205\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.5. D\u00e9coction de Shen Nao Fu Yuan (SNFYD)<\/h4>\n<p id=\"p0235\">SNFYD est une prescription efficace pour les accidents vasculaires c\u00e9r\u00e9braux isch\u00e9miques bas\u00e9e sur la th\u00e9orie du traitement simultan\u00e9 des reins et du cerveau. Sa composition est :\u00a0<em>Base d&#039;astragale<\/em>\u00a030g<em>,\u00a0<\/em><em><a class=\"topic-link\" title=\"Apprenez-en davantage sur Rehmanniae gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/rehmannia\">Rehmanniae<\/a><\/em><em>\u00a0Radix Praeparata<\/em>\u00a010g<em>, Corni Fructus<\/em>\u00a010g<em>, Rhizome de Dioscoreae<\/em>\u00a015g<em>, Rhodiolae Crenulatae Radix Et Rhizoma<\/em>\u00a020g<em>,\u00a0<\/em><em><a class=\"topic-link\" title=\"Apprenez-en davantage sur Moutan Cortex gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/moutan-cortex\">Cortex Moutan<\/a><\/em>\u00a010g<em>, Angelicae Sinensis Radix<\/em>\u00a010g<em>, Paeoniae Radix Rubra<\/em>\u00a010g<em>,\u00a0<\/em><em><a class=\"topic-link\" title=\"Apprenez-en davantage sur Pheretima gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/pheretima\">Ph\u00e9r\u00e9tima<\/a><\/em>\u00a010g\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib248\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib248\"><span class=\"anchor-text\">[248]<\/span><\/a>. Il est associ\u00e9 \u00e0 un grand nombre de m\u00e9dicaments revigorant le qi, reconstituant l&#039;essence et revigorant les reins, qui sont associ\u00e9s \u00e0 des garanties activatrices du sang et de dragage. Des \u00e9tudes ont montr\u00e9 qu&#039;apr\u00e8s la mod\u00e9lisation d&#039;autres minist\u00e8res, PC12 \u00e9tait consid\u00e9rablement endommag\u00e9 et que diverses cytokines dans la voie de la pyroptose \u00e9taient significativement augment\u00e9es.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib249\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib249\"><span class=\"anchor-text\">[249]<\/span><\/a>. Apr\u00e8s l&#039;intervention du s\u00e9rum contenant du SNFYD et de l&#039;INF39 dans les zones endommag\u00e9es\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les cellules PC12 gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pc12-cell-line\">Cellules PC12<\/a>, la morphologie et l&#039;activit\u00e9 des cellules PC12 ont \u00e9t\u00e9 am\u00e9lior\u00e9es et l&#039;activation de la voie de pyroptose NLRP3\/Caspase-1 a \u00e9t\u00e9 affaiblie en cons\u00e9quence. Il a indiqu\u00e9 que l\u2019inhibition de cette voie \u00e9tait li\u00e9e \u00e0 l\u2019am\u00e9lioration de l\u2019\u00e9tat cellulaire, et que SNFYD et INF39 pourraient inhiber l\u2019activation de cette voie. Il est sugg\u00e9r\u00e9 que le SNFYD puisse r\u00e9duire l&#039;apoptose inflammatoire des cellules nerveuses en inhibant NLRP3\/Caspase-1 et la voie de pyroptose en aval, prot\u00e9geant ainsi le tissu nerveux et atteignant l&#039;objectif de traiter l&#039;infarctus c\u00e9r\u00e9bral.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib250\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib250\"><span class=\"anchor-text\">[250]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0190\">\n<h4 id=\"sect0210\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.6. Autres extraits<\/h4>\n<p id=\"p0240\">De plus, des \u00e9tudes r\u00e9centes ont montr\u00e9 que les m\u00e9dicaments antithrombotiques tels que l&#039;h\u00e9parine peuvent am\u00e9liorer les l\u00e9sions pulmonaires en inhibant la pyroptose. Par exemple, Yang et al. ont d\u00e9couvert que l&#039;h\u00e9parine inhibe l&#039;apoptose des cellules endoth\u00e9liales pulmonaires en bloquant l&#039;activation de la caspase-11 induite par le LPS hMGB1, ce qui pourrait constituer un moyen potentiel de traiter les l\u00e9sions pulmonaires induites par la septic\u00e9mie.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib251\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib251\"><span class=\"anchor-text\">[251]<\/span><\/a>. Prathapan et coll. a d\u00e9couvert que l&#039;eau de coco tendre a des effets antioxydants et antithrombotiques de mani\u00e8re\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019infarctus du myocarde exp\u00e9rimental gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/experimental-myocardial-infarction\">infarctus du myocarde exp\u00e9rimental<\/a>\u00a0mod\u00e8le\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib252\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib252\"><span class=\"anchor-text\">[252]<\/span><\/a>, tandis que le jus de noix de coco jeune peut r\u00e9duire consid\u00e9rablement certaines des pathologies associ\u00e9es \u00e0\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la maladie d\u2019Alzheimer gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/alzheimer-disease\">La maladie d&#039;Alzheimer<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib253\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib253\"><span class=\"anchor-text\">[253]<\/span><\/a>. Il est indiqu\u00e9 que l&#039;eau de coco pourrait \u00eatre un inhibiteur potentiel de la pyroptose et que son r\u00f4le dans la r\u00e9gulation de la pyroptose dans l&#039;IS pourrait \u00eatre \u00e9tudi\u00e9 \u00e0 l&#039;avenir.<\/p>\n<p id=\"p0245\"><span class=\"small-caps\">L<\/span>-l&#039;arginine est un compos\u00e9 organique pr\u00e9sent dans\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la protamine gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/protamine\">protamine<\/a>\u00a0en grande quantit\u00e9\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib254\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib254\"><span class=\"anchor-text\">[254]<\/span><\/a>. C&#039;est un pr\u00e9curseur pour la synth\u00e8se de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019oxyde nitrique gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nitric-oxide\">l&#039;oxyde nitrique<\/a>\u00a0(NO), qui prot\u00e8ge l\u2019endoth\u00e9lium intact des vaisseaux sanguins, agit comme un\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les vasodilatateurs gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vasodilator-agent\">vasodilatateur<\/a>\u00a0et une mol\u00e9cule anti-ath\u00e9roscl\u00e9reuse endog\u00e8ne\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib254\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib254\"><span class=\"anchor-text\">[254]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib255\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib255\"><span class=\"anchor-text\">[255]<\/span><\/a>. Les exp\u00e9riences sur les animaux montrent que\u00a0<span class=\"small-caps\">L<\/span>-l&#039;arginine peut avoir un complexe\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019anticoagulation gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/anticoagulation\">anticoagulation<\/a>, anticoagulation et\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la fibrinolyse gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/fibrinolysis\">fibrinolyse<\/a>\u00a0effets\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib255\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib255\"><span class=\"anchor-text\">[255]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib256\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib256\"><span class=\"anchor-text\">[256]<\/span><\/a>. Chez les rats hypertendus, Cylwik et al. trouv\u00e9 ceci\u00a0<span class=\"small-caps\">L<\/span>-l&#039;arginine pourrait r\u00e9duire la tension art\u00e9rielle chez les rats, et un traitement \u00e0 long terme raccourcirait le temps de dissolution du caillot d&#039;euglobuline et le temps de saignement, et inhiberait l&#039;agr\u00e9gation plaquettaire induite par le collag\u00e8ne. Il est sugg\u00e9r\u00e9 que\u00a0<span class=\"small-caps\">L<\/span>-l&#039;arginine joue un effet antithrombotique dans un mod\u00e8le de rat hypertendu de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la thrombose veineuse gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/phlebothrombosis\">la thrombose veineuse<\/a>\u00a0d&#039;une mani\u00e8re complexe\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib256\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib256\"><span class=\"anchor-text\">[256]<\/span><\/a>. Une \u00e9tude r\u00e9cente a montr\u00e9 que\u00a0<span class=\"small-caps\">L<\/span>-l&#039;arginine peut \u00eatre un inhibiteur potentiel de la pyroptose : Tanuseputero et al. sugg\u00e9r\u00e9 que\u00a0<span class=\"small-caps\">L<\/span>-l&#039;arginine peut inhiber partiellement l&#039;inflammasome NLRP3 pour att\u00e9nuer les effets du sepsis.\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur l\u2019insuffisance r\u00e9nale aigu\u00eb gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/acute-kidney-injury\">l\u00e9sion r\u00e9nale aigu\u00eb<\/a>\u00a0Chez la souris\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib257\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib257\"><span class=\"anchor-text\">[257]<\/span><\/a>. Compte tenu des activit\u00e9s inflammatoires vasodilatatrices, antithrombotiques et inhibantes de NLRP3 de\u00a0<span class=\"small-caps\">L<\/span>-arginine, il est sugg\u00e9r\u00e9 que\u00a0<span class=\"small-caps\">L<\/span>-l&#039;arginine peut potentiellement augmenter le flux sanguin dans la zone isch\u00e9mique et inhiber la pyroptose dans l&#039;IS.<\/p>\n<div>\n<p id=\"p0250\">Le r\u00e9sum\u00e9 des produits naturels r\u00e9gulant la pyroptose est pr\u00e9sent\u00e9 dans\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#tbl0010\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"tbl0010\"><span class=\"anchor-text\">Tableau 2<\/span><\/a>.<\/p>\n<div id=\"tbl0010\" class=\"tables colsep-0 rowsep-0 frame-topbot\">\n<p id=\"sp0025\"><span class=\"label\">Tableau 2<\/span>. Le r\u00e9sum\u00e9 des compos\u00e9s naturels r\u00e9gulant la pyroptose.<\/p>\n<div class=\"groups\">\n<table>\n<thead>\n<tr class=\"rowsep-1\">\n<th scope=\"col\">Produits naturels<\/th>\n<th scope=\"col\">Mod\u00e8le\/Maladie<\/th>\n<th scope=\"col\">Esp\u00e8ces<\/th>\n<th scope=\"col\">Effets<\/th>\n<th scope=\"col\">R\u00e9f\u00e9rence<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<th scope=\"row\">Gastrodine<\/th>\n<td>Occlusion\/Reperfusion de l&#039;art\u00e8re c\u00e9r\u00e9brale moyenne (MCAO\/R), privation\/r\u00e9oxyg\u00e9nation en oxyg\u00e8ne-glucose (OGD\/R)<\/td>\n<td>Rattus norvegicus et neurones corticaux rimaires de Rattus norvegicus<\/td>\n<td>Inhibe la pyroptose en r\u00e9gulant n\u00e9gativement le NLRP3, les facteurs inflammatoires (IL-1\u03b2, IL-18) et la caspase-1 cliv\u00e9e\u00a0; r\u00e9gule l&#039;axe lncRNA NEAT1\/miR-22-3p et l&#039;axe lncRNA NEAT1\/miR-22-3p<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib204\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib204\"><span class=\"anchor-text\">[204]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Tanshinone IIA<\/th>\n<td>Autres minist\u00e8res\/R<\/td>\n<td>Cellules BV2 (microglies de Mus musculus)<\/td>\n<td>R\u00e9duit l&#039;expression de l&#039;IL-1\u03b2 et de l&#039;IL-18 dans la voie de signalisation inflammatoire NLRP3<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib205\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib205\"><span class=\"anchor-text\">[205]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">L\u00e9onurine<\/th>\n<td>MCAO<\/td>\n<td>Rattus norvegicus<\/td>\n<td>R\u00e9duit l&#039;expression de NLRP3<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib206\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib206\"><span class=\"anchor-text\">[206]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Pa\u00e9oniflorine<\/th>\n<td>MCAO<\/td>\n<td>Rattus norvegicus<\/td>\n<td>Inhibe les niveaux de NLRP3, Caspase-1 et IL-1\u03b2<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib209\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib209\"><span class=\"anchor-text\">[209]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Butylphtalide<\/th>\n<td>MCAO<\/td>\n<td>Rattus norvegicus<\/td>\n<td>R\u00e9gule la voie de signalisation de l&#039;inflammasome NLRP3<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib210\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib210\"><span class=\"anchor-text\">[210]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Br\u00e9viscapine<\/th>\n<td>MCAO\/R<\/td>\n<td>Rattus norvegicus<\/td>\n<td>Inhibe l&#039;activation des cellules inflammatoires NLRP3 dans l&#039;hippocampe des rats CCI, r\u00e9gule \u00e0 la baisse l&#039;expression des prot\u00e9ines Caspase 1, IL-6 et IL-1\u03b2, inhibe l&#039;activation de la prot\u00e9ine Caspase-3<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib211\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib211\"><span class=\"anchor-text\">[211]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Resv\u00e9ratrol<\/th>\n<td>MCAO\/R<\/td>\n<td>Rattus norvegicus<\/td>\n<td>R\u00e9gule l&#039;inflammasome NLRP3 des microglies, la Caspase-1 et ZO-1<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib212\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib212\"><span class=\"anchor-text\">[212]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Acide salvianolique<\/th>\n<td>MCAO\/R et OGD\/R<\/td>\n<td>Rattus norvegicus et microglies de Rattus norvegicus<\/td>\n<td>Inhibe l&#039;activation de l&#039;inflammasome NLRP3 et l&#039;expression des prot\u00e9ines li\u00e9es \u00e0 l&#039;inflammasome\/pyroxie NLRP3<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib213\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib213\"><span class=\"anchor-text\">[213]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Hispiduline<\/th>\n<td>MCAO<\/td>\n<td>Rattus norvegicus<\/td>\n<td>Inhibe la pyroptose m\u00e9di\u00e9e par NLRP3 en r\u00e9gulant la voie de signalisation AMPK\/GSK3\u03b2<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib214\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib214\"><span class=\"anchor-text\">[214]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Astragaloside IV<\/th>\n<td>MCAO\/R<\/td>\n<td>Rattus norvegicus<\/td>\n<td>Inhibe l&#039;activation de l&#039;inflammasome NLRP3\u00a0; r\u00e9duit les niveaux de prot\u00e9ines NLRP3, Caspase-1, pro-IL-1\u03b2, IL-1\u03b2, pro-IL-18 et IL-18 dans le tissu c\u00e9r\u00e9bral\u00a0; inhibe l&#039;expression de la prot\u00e9ine NF-\u03baB phosphoryl\u00e9e<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib223\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib223\"><span class=\"anchor-text\">[223]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Saponines de Panax notoginseng<\/th>\n<td>MCAO\/R<\/td>\n<td>Rattus norvegicus<\/td>\n<td>R\u00e9gule la voie PINK1\/Parkin\u00a0; inhibe l&#039;activation de l&#039;inflammasome NLRP3<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib232\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib232\"><span class=\"anchor-text\">[232]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">D\u00e9coction Taohong Siwu<\/th>\n<td>MCAO<\/td>\n<td>Rattus norvegicus<\/td>\n<td>R\u00e9duit les niveaux de prot\u00e9ines DRP1, NLRP3, Caspase-1 et IL-1 \u03b2<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib233\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib233\"><span class=\"anchor-text\">[233]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">D\u00e9coction Taohong Siwu<\/th>\n<td>MCAO\/R<\/td>\n<td>Rattus norvegicus<\/td>\n<td>Inhibe les voies de signalisation HMGB1\/TLR4\/NF-kB et MAPK<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib234\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib234\"><span class=\"anchor-text\">[234]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">G\u00e9lules Naoxinqing<\/th>\n<td>MCAO\/R<\/td>\n<td>Meriones unguiculatus<\/td>\n<td>R\u00e9gule \u00e0 la baisse les prot\u00e9ines ASC, NLRP3 et Caspase-1\u00a0; R\u00e9duit les teneurs en IL-18 et IL-1\u03b2.<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib239\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib239\"><span class=\"anchor-text\">[239]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">D\u00e9coction Buyang Huanwu<\/th>\n<td>MCAO\/R<\/td>\n<td>Rattus norvegicus<\/td>\n<td>Inhibe l&#039;expression des prot\u00e9ines NLRP3, ASC, pro-caspase-1, caspase-1 et IL-1\u03b2 de la voie canonique de la pyroptose m\u00e9di\u00e9e par NLRP3<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib244\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib244\"><span class=\"anchor-text\">[244]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">D\u00e9coction de Longzhi<\/th>\n<td>MCAO\/R<\/td>\n<td>Rattus norvegicus<\/td>\n<td>R\u00e9gule \u00e0 la baisse l&#039;expression des prot\u00e9ines Caspase-1 et IL-18<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib245\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib245\"><span class=\"anchor-text\">[245]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Yiqi Huoxue Ordonnance<\/th>\n<td>MCAO<\/td>\n<td>Rattus norvegicus<\/td>\n<td>R\u00e9duit les niveaux d&#039;IL-1\u03b2, de TNF-\u03b1 et d&#039;IL-18 ainsi que l&#039;expression relative de P2RX7, Caspase-1, Caspase-11 et GSDMD<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib247\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib247\"><span class=\"anchor-text\">[247]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">D\u00e9coction de Shen Nao Fu Yuan<\/th>\n<td>Autres minist\u00e8res<\/td>\n<td>Cellules PC12 de Rattus norvegicus<\/td>\n<td>Inhibe NLRP3\/Caspase-1<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib250\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib250\"><span class=\"anchor-text\">[250]<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/section>\n<\/section>\n<section id=\"sec0195\">\n<h2 id=\"sect0215\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">6. Perspectives<\/h2>\n<p id=\"p0255\">Notre \u00e9quipe de recherche \u00e9tudie depuis longtemps le mode de mort cellulaire programm\u00e9e de divers groupes de cellules (tels que les neurones, les microglies et les astrocytes) dans l\u2019unit\u00e9 neuronale vasculaire apr\u00e8s une IS. En combinaison avec d&#039;autres rapports de recherche, nous avons constat\u00e9 que divers modes de mort cellulaire tels que l&#039;apoptose, la ferroptose et l&#039;autophagie se produisaient apr\u00e8s l&#039;EI, et que la morphologie de l&#039;apoptose et de la pyroptose pr\u00e9sentait certaines similitudes.\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la neuroinflammation gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroinflammation\">Neuroinflammation<\/a>\u00a0apr\u00e8s l&#039;EI est le processus pathologique le plus important conduisant \u00e0 une l\u00e9sion c\u00e9r\u00e9brale, dans laquelle la pyroptose est une partie importante de la neuroinflammation. Ceci sugg\u00e8re que la pyroptose est anormalement importante dans la mort cellulaire programm\u00e9e li\u00e9e \u00e0 la neuroinflammation apr\u00e8s une isch\u00e9mie c\u00e9r\u00e9brale. Les voies de signalisation associ\u00e9es d\u00e9clench\u00e9es par la pyroptose recoupent \u00e9galement d&#039;autres voies de mort cellulaire programm\u00e9e, ce qui sugg\u00e8re que le d\u00e9veloppement de m\u00e9dicaments ciblant la pyroptose est un moyen important de traiter l&#039;EI.<\/p>\n<p id=\"p0260\">Pour l&#039;\u00e9tude actuelle, il reste encore des domaines \u00e0 am\u00e9liorer\u00a0: (1) En raison des probl\u00e8mes de normalisation et d&#039;unification dans le mod\u00e8le animal de l&#039;\u00e9tude actuelle, les conclusions sur la pyroptose dans diff\u00e9rentes cellules du\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le syst\u00e8me nerveux gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nervous-system\">syst\u00e8me nerveux<\/a>\u00a0sont incoh\u00e9rents. Par cons\u00e9quent, \u00e0 l\u2019avenir, les recherches sur la pyroptose n\u00e9cessiteront un mod\u00e8le stable plus standardis\u00e9 et unifi\u00e9 dans les mod\u00e8les animaux d\u2019accident vasculaire c\u00e9r\u00e9bral isch\u00e9mique, qui pourra \u00e9galement d\u00e9terminer l\u2019effet r\u00e9el des m\u00e9dicaments anti-pyroptose. (2) Des \u00e9tudes futures pourront v\u00e9rifier les effets protecteurs \u00e0 long terme du cerveau des compos\u00e9s naturels et les m\u00e9canismes r\u00e9gulant la pyroptose dans divers mod\u00e8les d&#039;accidents vasculaires c\u00e9r\u00e9braux de rongeurs et de grands mammif\u00e8res. \u00c0 l&#039;avenir, il faudra accorder davantage d&#039;attention \u00e0\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la pharmacocin\u00e9tique gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pharmacokinetics\">pharmacocin\u00e9tique<\/a>,\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la pharmacodynamie gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pharmacodynamics\">pharmacodynamique<\/a>, et les propri\u00e9t\u00e9s toxicologiques des compos\u00e9s naturels qui modulent actuellement la pyroptose. (3) De plus, l&#039;effet synergique de la combinaison de compos\u00e9s naturels dans la r\u00e9gulation de la pyroptose dans les accidents vasculaires c\u00e9r\u00e9braux isch\u00e9miques c\u00e9r\u00e9braux et l&#039;effet neuroprotecteur de l&#039;inhibition de la neuroinflammation doivent \u00eatre explor\u00e9s \u00e0 l&#039;avenir. (4) Si tous les r\u00e9sultats sont favorables, l&#039;\u00e9tape suivante consiste \u00e0 mener\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les essais cliniques gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/clinical-trial\">essais cliniques<\/a>\u00a0de potentiel\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur les compos\u00e9s phytochimiques gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l&#039;IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/phytochemical\">produits phytochimiques<\/a>\u00a0pour \u00e9tudier leurs effets neuroprotecteurs sur l&#039;isch\u00e9mie\/accident vasculaire c\u00e9r\u00e9bral (par exemple, l&#039;\u00e9quipe m\u00e8ne actuellement un essai clinique sur Naotai Fang dans le traitement de la maladie des petits vaisseaux c\u00e9r\u00e9braux\u00a0: ChiCTR1900024524).<\/p>\n<\/section>\n<section id=\"sec0200\">\n<h2 id=\"sect0220\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">7. R\u00e9sum\u00e9<\/h2>\n<p id=\"p0265\">La pyroptose, en tant que mort cellulaire programm\u00e9e pro-inflammatoire, joue un r\u00f4le important dans le processus pathologique de l&#039;accident vasculaire c\u00e9r\u00e9bral isch\u00e9mique en induisant la mort cellulaire et la neuroinflammation principalement par la voie pyroptotique classique m\u00e9di\u00e9e par la Caspase-1. La relation entre les voies pyroptotiques non canoniques et l&#039;IS reste \u00e0 \u00e9lucider. D&#039;autres m\u00e9canismes de la pyroptose n\u00e9cessiteront des \u00e9tudes plus approfondies \u00e0 l&#039;avenir. \u00c0 l&#039;heure actuelle, des \u00e9tudes ont confirm\u00e9 que\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur le ciblage des m\u00e9dicaments gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/drug-delivery-system\">m\u00e9dicaments ciblant<\/a>\u00a0Les prot\u00e9ines cl\u00e9s de la voie de la pyroptose peuvent att\u00e9nuer dans une certaine mesure les l\u00e9sions c\u00e9r\u00e9brales isch\u00e9miques, mais leurs recherches se limitent principalement aux exp\u00e9rimentations cellulaires et animales, et il y a un manque de\u00a0<a class=\"topic-link\" title=\"Apprenez-en davantage sur la recherche clinique gr\u00e2ce aux pages th\u00e9matiques g\u00e9n\u00e9r\u00e9es par l\u2019IA de ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/clinical-research\">recherche clinique<\/a>\u00a0preuve. Par cons\u00e9quent, d\u2019autres recherches cliniques visant \u00e0 explorer le m\u00e9canisme de r\u00e9gulation de la pyroptose dans l\u2019IS devraient fournir de nouvelles strat\u00e9gies th\u00e9rapeutiques et une base th\u00e9orique pour la pr\u00e9vention et le traitement de l\u2019AVC isch\u00e9mique. Concernant la r\u00e9gulation de la pyroptose par des compos\u00e9s naturels, gr\u00e2ce \u00e0 notre g\u00e9n\u00e9ralisation, on peut constater que les compos\u00e9s naturels v\u00e9g\u00e9taux peuvent r\u00e9guler l&#039;isch\u00e9mie c\u00e9r\u00e9brale en r\u00e9gulant la pyroptose non seulement sur un seul composant. Les compos\u00e9s v\u00e9g\u00e9taux naturels \u00e0 plusieurs composants peuvent \u00e9galement pr\u00e9senter des effets synergiques potentiels dans la modulation de la cascade inflammatoire d\u00e9clench\u00e9e par la pyroptose. Cela nous incite \u00e0 \u00e9tudier \u00e0 l\u2019avenir les effets r\u00e9gulateurs de divers compos\u00e9s naturels sur la neuroinflammation m\u00e9di\u00e9e par la pyroptose et provoqu\u00e9e par diff\u00e9rentes voies de signalisation.<\/p>\n<\/section>\n<section id=\"sec0205\">\n<h2 id=\"sect0225\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">D\u00e9claration de contribution \u00e0 la paternit\u00e9 du CRediT<\/h2>\n<p id=\"p0270\"><strong>Kailin Yang\u00a0:<\/strong>\u00a0Conceptualisation, m\u00e9thodologie, analyse formelle, enqu\u00eate, r\u00e9daction \u2013 \u00e9bauche originale\u00a0;\u00a0<strong>Liuting Zeng\u00a0:<\/strong>\u00a0Conceptualisation, m\u00e9thodologie, logiciels, analyse formelle, enqu\u00eate, r\u00e9daction \u2013 \u00e9bauche originale\u00a0;\u00a0<strong>Jinsong Zeng\u00a0:<\/strong>\u00a0M\u00e9thodologie, Analyse formelle, Enqu\u00eate\u00a0;\u00a0<strong>Tingting Bao\u00a0:<\/strong>\u00a0M\u00e9thodologie, analyse formelle, enqu\u00eate, r\u00e9daction \u2013 version originale\u00a0;\u00a0<strong>Xiao Yuan\u00a0:<\/strong>\u00a0M\u00e9thodologie, Analyse formelle, Enqu\u00eate\u00a0;\u00a0<strong>Shanshan Wang\u00a0:<\/strong>\u00a0M\u00e9thodologie, Analyse formelle, Enqu\u00eate\u00a0;\u00a0<strong>Wang Xiang :<\/strong>\u00a0M\u00e9thodologie, Analyse formelle, Enqu\u00eate\u00a0;\u00a0<strong>Hao Xu\u00a0:<\/strong>\u00a0M\u00e9thodologie, Analyse formelle, Enqu\u00eate\u00a0;\u00a0<strong>Jinwen Ge\u00a0:<\/strong>\u00a0Conceptualisation, m\u00e9thodologie, analyse formelle, enqu\u00eate, r\u00e9daction \u2013 r\u00e9vision et \u00e9dition.<\/p>\n<\/section>\n<\/div>\n<section id=\"coi0005\">\n<h2 id=\"sect0230\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">D\u00e9claration de conflit d&#039;int\u00e9r\u00eats<\/h2>\n<p id=\"p0275\">Les auteurs d\u00e9clarent qu\u2019ils n\u2019ont aucun int\u00e9r\u00eat financier concurrent connu ni aucune relation personnelle qui aurait pu sembler influencer le travail rapport\u00e9 dans cet article.<\/p>\n<\/section>\n<section id=\"ack0005\">\n<h2 id=\"sect0235\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">Remerciements<\/h2>\n<p id=\"p0280\">Ce travail est soutenu par le\u00a0<span id=\"gs1\">Fondation nationale des sciences naturelles de Chine<\/span>\u00a0(<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs1\"><span class=\"anchor-text\">81774174<\/span><\/a>), le\u00a0<span id=\"gs2\">Projet cl\u00e9 national de recherche et de d\u00e9veloppement de la Chine<\/span>\u00a0(Non.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs2\"><span class=\"anchor-text\">2018YFC1704904<\/span><\/a>),\u00a0<span id=\"gs3\">Fondation nationale des sciences naturelles de la province du Hunan<\/span>, Chine (<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs3\"><span class=\"anchor-text\">2020JJ5424<\/span><\/a>\u00a0et\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs3\"><span class=\"anchor-text\">2020JJ5442<\/span><\/a>),\u00a0<span id=\"gs4\">Projet de fonds ouvert de discipline \u00ab Double premi\u00e8re classe \u00bb de l&#039;Universit\u00e9 de m\u00e9decine chinoise du Hunan pour la m\u00e9decine traditionnelle chinoise et occidentale int\u00e9gr\u00e9e<\/span>\u00a0(<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs4\"><span class=\"anchor-text\">2020ZXYJH08<\/span><\/a>\u00a0et\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs4\"><span class=\"anchor-text\">2020ZXYJH09<\/span><\/a>),\u00a0<span id=\"gs5\">Projet de fonds pour la jeunesse du minist\u00e8re provincial de l&#039;\u00c9ducation du Hunan<\/span>\u00a0(<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs5\"><span class=\"anchor-text\">21B0386<\/span><\/a>).<\/p>\n<\/section>\n<\/div>\n<div class=\"text-content u-font-serif\">\n<section id=\"da0005\">\n<h2 id=\"sect0020\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">Disponibilit\u00e9 des donn\u00e9es et du mat\u00e9riel<\/h2>\n<p id=\"p0020\">Les donn\u00e9es utilis\u00e9es pour \u00e9tayer les conclusions de cette \u00e9tude sont incluses dans l\u2019article.<\/p>\n<\/section>\n<\/div>\n<div class=\"Tail text-s\"><\/div>\n<section id=\"bibliog0005\" class=\"bibliography u-font-serif text-s\">\n<h2 class=\"section-title u-h4 u-margin-l-top u-margin-xs-bottom\">Les r\u00e9f\u00e9rences<\/h2>\n<section id=\"bb0005\" class=\"bibliography-sec\">\n<ol id=\"reference-links-bb0005\" class=\"references\">\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib1\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib1\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[1]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">LE Evans, JL Taylor, CJ Smith, HAT Pritchard, AS Greenstein, SM Allan<\/div>\n<div id=\"ref-id-sbref1\" class=\"title text-m\">Comorbidit\u00e9s cardiovasculaires, inflammation et maladie des petits vaisseaux c\u00e9r\u00e9braux<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Cardiovasc Res., 117 (13) (2021), pages 2575-2588,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1093\/cvr\/cvab284\" target=\"_blank\" rel=\"noreferrer noopener\"><span 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Biol., 1000 (2017), pages 131-151,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1007\/978-981-10-4304-8_9\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1007\/978-981-10-4304-8_9<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85032976954&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref2\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Clinical%20Evidence%20of%20Exercise%20Benefits%20for%20Stroke&amp;publication_year=2017&amp;author=P.%20Han&amp;author=W.%20Zhang&amp;author=L.%20Kang&amp;author=Y.%20Ma&amp;author=L.%20Fu&amp;author=L.%20Jia&amp;author=H.%20Yu&amp;author=X.%20Chen&amp;author=L.%20Hou&amp;author=L.%20Wang&amp;author=X.%20Yu&amp;author=M.%20Kohzuki&amp;author=Q.%20Guo\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref2\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib3\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib3\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[3]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">VL Feigin, M. 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Stroke, 17 (1) (2022), p. 18-29,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1177\/17474930211065917\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1177\/17474930211065917<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Afficher le PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">Cet article est en acc\u00e8s libre.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85122375323&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref3\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=World%20Stroke%20Organization%20%3A%20Global%20Stroke%20Fact%20Sheet%202022&amp;publication_year=2022&amp;author=V.L.%20Feigin&amp;author=M.%20Brainin&amp;author=B.%20Norrving&amp;author=S.%20Martins&amp;author=R.L.%20Sacco&amp;author=W.%20Hacke&amp;author=M.%20Fisher&amp;author=J.%20Pandian&amp;author=P.%20Lindsay\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref3\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib4\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib4\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[4]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">PB Sporns, HJ Fullerton, S. Lee, H. Kim, WD Lo, MT Mackay, M. Wildgruber<\/div>\n<div id=\"ref-id-sbref4\" class=\"title text-m\">AVC de l&#039;enfance<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Nat. Le r\u00e9v\u00e9rend Dis. 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(Minne), 26 (2) (2020), p. 260-267,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1212\/CON.0000000000000831\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1212\/CON.0000000000000831<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span><\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85082634848&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref6\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Epidemiology%20and%20primary%20prevention%20of%20stroke&amp;publication_year=2020&amp;author=K.%20Furie\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref6\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib7\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib7\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[7]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">MS Ekker, EM Boot, AB Singhal, KS Tan, S. Debette, AM Tuladhar, FE de Leeuw<\/div>\n<div id=\"ref-id-sbref7\" class=\"title text-m\">\u00c9pid\u00e9miologie, \u00e9tiologie et prise en charge de l&#039;AVC isch\u00e9mique chez les jeunes adultes<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Lancet Neurol., 17 (9) (2018), pages 790 \u00e0 801,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/S1474-4422(18)30233-3\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/S1474-4422(18)30233-3<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1474442218302333\/pdfft?md5=477909fe66f856d9a85dc0241c093220&amp;pid=1-s2.0-S1474442218302333-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref7\"><span class=\"anchor-text\">Afficher le PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1474442218302333\" aria-describedby=\"ref-id-sbref7\"><span class=\"anchor-text\">Voir l&#039;article<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85051392583&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref7\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Epidemiology%2C%20aetiology%2C%20and%20management%20of%20ischaemic%20stroke%20in%20young%20adults&amp;publication_year=2018&amp;author=M.S.%20Ekker&amp;author=E.M.%20Boot&amp;author=A.B.%20Singhal&amp;author=K.S.%20Tan&amp;author=S.%20Debette&amp;author=A.M.%20Tuladhar&amp;author=F.E.%20de%20Leeuw\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref7\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib8\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib8\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[8]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">S. Wu, B. Wu, M. Liu, Z. Chen, W. Wang, CS Anderson, P. Sandercock, Y. Wang, Y. Huang, L. Cui, C. Pu, J. Jia, T. Zhang , X. Liu, S. Zhang, P. Xie, D. Fan, X. Ji, KL Wong, L. Wang<\/div>\n<div id=\"ref-id-sbref8\" class=\"title text-m\">Collaboration en Chine pour une \u00e9tude sur l\u2019AVC. AVC en Chine\u00a0: avanc\u00e9es et d\u00e9fis en \u00e9pid\u00e9miologie, pr\u00e9vention et gestion<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Lancet Neurol., 18 (4) (2019), pages 394-405,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/S1474-4422(18)30500-3\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/S1474-4422(18)30500-3<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1474442218305003\/pdfft?md5=ddbfdb704b02c545afc4c110452fd724&amp;pid=1-s2.0-S1474442218305003-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref8\"><span class=\"anchor-text\">Afficher le PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1474442218305003\" aria-describedby=\"ref-id-sbref8\"><span class=\"anchor-text\">Voir l&#039;article<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85062907971&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref8\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=China%20Stroke%20Study%20Collaboration.%20Stroke%20in%20China%3A%20advances%20and%20challenges%20in%20epidemiology%2C%20prevention%2C%20and%20management&amp;publication_year=2019&amp;author=S.%20Wu&amp;author=B.%20Wu&amp;author=M.%20Liu&amp;author=Z.%20Chen&amp;author=W.%20Wang&amp;author=C.S.%20Anderson&amp;author=P.%20Sandercock&amp;author=Y.%20Wang&amp;author=Y.%20Huang&amp;author=L.%20Cui&amp;author=C.%20Pu&amp;author=J.%20Jia&amp;author=T.%20Zhang&amp;author=X.%20Liu&amp;author=S.%20Zhang&amp;author=P.%20Xie&amp;author=D.%20Fan&amp;author=X.%20Ji&amp;author=K.L.%20Wong&amp;author=L.%20Wang\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref8\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib9\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib9\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[9]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">HF Yan, QZ Tuo, QZ Yin, P. 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R\u00e9s, 41 (3) (2020), pp. 220-230,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.24272\/j.issn.2095-8137.2020.042\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.24272\/j.issn.2095-8137.2020.042<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85084692954&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref9\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=The%20pathological%20role%20of%20ferroptosis%20in%20ischemiareperfusion-related%20injury&amp;publication_year=2020&amp;author=H.F.%20Yan&amp;author=Q.Z.%20Tuo&amp;author=Q.Z.%20Yin&amp;author=P.%20Lei\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref9\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib10\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib10\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[10]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">MY Wu, GT Yiang, WT Liao, AP Tsai, YL Cheng, PW Cheng, CY Li, CJ Li<\/div>\n<div id=\"ref-id-sbref10\" class=\"title text-m\">Concepts m\u00e9canistiques actuels dans les l\u00e9sions d&#039;isch\u00e9mie et de reperfusion<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Cell PhysiolBiochem, 46 (4) (2018), pages 1650-1667,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1159\/000489241\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1159\/000489241<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Afficher le PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">Cet article est en acc\u00e8s libre.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85046014150&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref10\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Current%20Mechanistic%20Concepts%20in%20Ischemia%20and%20Reperfusion%20Injury&amp;publication_year=2018&amp;author=M.Y.%20Wu&amp;author=G.T.%20Yiang&amp;author=W.T.%20Liao&amp;author=A.P.%20Tsai&amp;author=Y.L.%20Cheng&amp;author=P.W.%20Cheng&amp;author=C.Y.%20Li&amp;author=C.J.%20Li\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref10\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib11\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib11\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[11]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">X. 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Med Cell Longev., 2021 (2021), article 1587922,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1155\/2021\/1587922\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1155\/2021\/1587922<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85118990959&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref11\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Targeting%20Ferroptosis%3A%20Pathological%20Mechanism%20and%20Treatment%20of%20Ischemia-Reperfusion%20Injury&amp;publication_year=2021&amp;author=X.%20Li&amp;author=N.%20Ma&amp;author=J.%20Xu&amp;author=Y.%20Zhang&amp;author=P.%20Yang&amp;author=X.%20Su&amp;author=Y.%20Xing&amp;author=N.%20An&amp;author=F.%20Yang&amp;author=G.%20Zhang&amp;author=L.%20Zhang&amp;author=Y.%20Xing\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref11\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib12\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib12\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[12]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">M. Mahjoubin-T\u00e9h\u00e9ran, S. Rezaei, A. Jesmani, N. Birang, K. Morshedi, H. Khanbabaei, H. Khan, A. Piranviseh, M. Nejati, M. Aschner, H. Mirzaei<\/div>\n<div id=\"ref-id-sbref12\" class=\"title text-m\">Nouveaux acteurs \u00e9pig\u00e9n\u00e9tiques dans la pathogen\u00e8se des accidents vasculaires c\u00e9r\u00e9braux\u00a0: des ARN non codants aux ARN exosomiques non codants<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Biom\u00e9de. Pharm., 140 (2021), article 111753,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.biopha.2021.111753\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.biopha.2021.111753<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332221005357\/pdfft?md5=13a6710773ddbd431c3757f9058711d2&amp;pid=1-s2.0-S0753332221005357-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref12\"><span class=\"anchor-text\">Afficher le PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332221005357\" aria-describedby=\"ref-id-sbref12\"><span class=\"anchor-text\">Voir l&#039;article<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85108373807&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref12\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=New%20epigenetic%20players%20in%20stroke%20pathogenesis%3A%20From%20non-coding%20RNAs%20to%20exosomal%20non-coding%20RNAs&amp;publication_year=2021&amp;author=M.%20Mahjoubin-Tehran&amp;author=S.%20Rezaei&amp;author=A.%20Jesmani&amp;author=N.%20Birang&amp;author=K.%20Morshedi&amp;author=H.%20Khanbabaei&amp;author=H.%20Khan&amp;author=A.%20Piranviseh&amp;author=M.%20Nejati&amp;author=M.%20Aschner&amp;author=H.%20Mirzaei\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref12\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib13\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib13\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[13]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">K. Yang, L. Zeng, A. Ge, S. Wang, J. Zeng, X. Yuan, Z. Mei, G. Wang, J. Ge<\/div>\n<div id=\"ref-id-sbref13\" class=\"title text-m\">Une revue syst\u00e9matique des progr\u00e8s de la recherche sur la neuroinflammation et l&#039;immunor\u00e9gulation \u00e0 ARN non codant dans l&#039;infarctus c\u00e9r\u00e9bral\/les l\u00e9sions d&#039;isch\u00e9mie-reperfusion<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Devant. Immunol., 13 (2022), article 930171,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.3389\/fimmu.2022.930171\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.3389\/fimmu.2022.930171<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85140346409&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref13\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=A%20systematic%20review%20of%20theresearch%20progress%20of%20non-coding%20RNAin%20neuroinflammation%20and%20immuneregulation%20in%20cerebral%20infarctionischemia-reperfusion%20injury&amp;publication_year=2022&amp;author=K.%20Yang&amp;author=L.%20Zeng&amp;author=A.%20Ge&amp;author=S.%20Wang&amp;author=J.%20Zeng&amp;author=X.%20Yuan&amp;author=Z.%20Mei&amp;author=G.%20Wang&amp;author=J.%20Ge\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref13\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib14\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib14\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[14]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">K. Yang, L. Zeng, X. Yuan, S. Wang, A. Ge, H. Xu, J. Zeng, J. Ge<\/div>\n<div id=\"ref-id-sbref14\" class=\"title text-m\">Le m\u00e9canisme de la ferroptose r\u00e9gulant le stress oxydatif dans les accidents vasculaires c\u00e9r\u00e9braux isch\u00e9miques et le m\u00e9canisme de r\u00e9gulation des composants actifs pharmacologiques naturels<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Biom\u00e9de. Pharm., 154 (2022), article 113611,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.biopha.2022.113611\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.biopha.2022.113611<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222010009\/pdfft?md5=c10c64d3830cfc66d624f7112443f8c0&amp;pid=1-s2.0-S0753332222010009-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref14\"><span class=\"anchor-text\">Afficher le PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222010009\" aria-describedby=\"ref-id-sbref14\"><span class=\"anchor-text\">Voir l&#039;article<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85137285700&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref14\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=The%20mechanism%20of%20ferroptosis%20regulating%20oxidative%20stress%20in%20ischemic%20stroke%20and%20the%20regulation%20mechanism%20of%20natural%20pharmacological%20active%20components&amp;publication_year=2022&amp;author=K.%20Yang&amp;author=L.%20Zeng&amp;author=X.%20Yuan&amp;author=S.%20Wang&amp;author=A.%20Ge&amp;author=H.%20Xu&amp;author=J.%20Zeng&amp;author=J.%20Ge\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref14\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib15\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib15\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[15]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">PJ Kelly, R. Lemmens, G. 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Immun., 91 (2021), pages 649 \u00e0 667,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.bbi.2020.09.025\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.bbi.2020.09.025<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0889159120314835\/pdfft?md5=7f20c8efadebc4ba2e72b6ff156a4240&amp;pid=1-s2.0-S0889159120314835-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref16\"><span class=\"anchor-text\">Afficher le PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0889159120314835\" aria-describedby=\"ref-id-sbref16\"><span class=\"anchor-text\">Voir l&#039;article<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85092252055&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref16\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Filling%20the%20gaps%20on%20stroke%20research%3A%20Focus%20on%20inflammation%20and%20immunity&amp;publication_year=2021&amp;author=D.%20Levard&amp;author=I.%20Buendia&amp;author=A.%20Lanquetin&amp;author=M.%20Glavan&amp;author=D.%20Vivien&amp;author=M.%20Rubio\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref16\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib17\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib17\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[17]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">J. 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Pharm., 150 (2022), article 112929,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.biopha.2022.112929\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.biopha.2022.112929<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222003183\/pdfft?md5=056cbffef01439e4b2fd4ed8e4300fd4&amp;pid=1-s2.0-S0753332222003183-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref20\"><span class=\"anchor-text\">Afficher le PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222003183\" aria-describedby=\"ref-id-sbref20\"><span class=\"anchor-text\">Voir l&#039;article<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85129378630&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref20\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Non-apoptotic%20cell%20death%20in%20ovarian%20cancer%3A%20Treatment%2C%20resistance%20and%20prognosis&amp;publication_year=2022&amp;author=J.%20Chen&amp;author=Z.%20Wei&amp;author=K.%20Fu&amp;author=Y.%20Duan&amp;author=M.%20Zhang&amp;author=K.%20Li&amp;author=T.%20Guo&amp;author=R.%20Yin\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref20\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib21\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib21\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[21]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">K. 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Pharm., 149 (2022), article 112875,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.biopha.2022.112875\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.biopha.2022.112875<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222002645\/pdfft?md5=8afe782b3281b7d53f8a3fd3ca1cf095&amp;pid=1-s2.0-S0753332222002645-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref21\"><span class=\"anchor-text\">Afficher le PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222002645\" aria-describedby=\"ref-id-sbref21\"><span class=\"anchor-text\">Voir l&#039;article<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85127230234&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref21\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Mechanism%20of%20cell%20death%20pathways%20in%20status%20epilepticus%20and%20related%20therapeutic%20agents&amp;publication_year=2022&amp;author=K.%20Du&amp;author=M.%20He&amp;author=D.%20Zhao&amp;author=Y.%20Wang&amp;author=C.%20Ma&amp;author=H.%20Liang&amp;author=W.%20Wang&amp;author=D.%20Min&amp;author=L.%20Xue&amp;author=F.%20Guo\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref21\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib22\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib22\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[22]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">X. Gou, D. Xu, F. Li, K. Hou, W. Fang, Y. Li<\/div>\n<div id=\"ref-id-sbref22\" class=\"title text-m\">Pyroptose dans l\u2019AVC \u2013 nouvelles connaissances sur les m\u00e9canismes de la maladie et les strat\u00e9gies th\u00e9rapeutiques<\/div>\n<\/div>\n<div class=\"host u-font-sans\">J. PhysiolBiochem, 77 (4) (2021), pages 511-529,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1007\/s13105-021-00817-w\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1007\/s13105-021-00817-w<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85105383446&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref22\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Pyroptosis%20in%20stroke-new%20insights%20into%20disease%20mechanisms%20and%20therapeutic%20strategies&amp;publication_year=2021&amp;author=X.%20Gou&amp;author=D.%20Xu&amp;author=F.%20Li&amp;author=K.%20Hou&amp;author=W.%20Fang&amp;author=Y.%20Li\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref22\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib23\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib23\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[23]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">A. 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Med, 22 (4) (2021), p. 1123,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.3892\/etm.2021.10557\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.3892\/etm.2021.10557<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Effect%20of%20the%20combination%20of%20astragaloside%20IV%20and%20Panax%20notoginseng%20saponins%20on%20pyroptosis%20and%20necroptosis%20in%20rat%20models%20of%20cerebral%20ischemia-reperfusion&amp;publication_year=2021&amp;author=B.%20Tang&amp;author=X.%20She&amp;author=C.Q.%20Deng\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref24\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib25\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib25\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[25]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">Y. 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Microbiol Immunol., 397 (2016), pages 23 \u00e0 42<\/div>\n<div class=\"comment\">10<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/doi.org\/10.1007\/978-3-319-41171-2_2\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref48\"><span class=\"anchor-text\">R\u00e9fCross<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-84982688438&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref48\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Structural%20mechanisms%20in%20NLR%20inflammasome%20assembly%20and%20signaling&amp;publication_year=2016&amp;author=Z.%20Hu&amp;author=J.%20Chai\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref48\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<p><span class=\"reference\"><span class=\"label\">(b)<\/span><\/span><\/p>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">A. 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Wu<\/div>\n<div id=\"ref-id-sbref49\" class=\"title text-m\">M\u00e9canismes structurels de l&#039;assemblage des inflammasomes<\/div>\n<\/div>\n<div class=\"host u-font-sans\">FEBS J., 282 (3) (2015), p. 435-444<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/doi.org\/10.1111\/febs.13133\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref49\"><span class=\"anchor-text\">R\u00e9fCross<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-84921730204&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref49\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Structural%20mechanisms%20of%20inflammasomeassembly&amp;publication_year=2015&amp;author=A.%20Lu&amp;author=H.%20Wu\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref49\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib51\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib51\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[51]<\/span><\/a><\/span><span class=\"reference\"><span class=\"label\">(un)<\/span><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">VA Rathinam, KA Fitzgerald<\/div>\n<div id=\"ref-id-sbref50\" class=\"title text-m\">Complexes inflammatoires : m\u00e9canismes \u00e9mergents et fonctions effectrices<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Cellule, 165 (4) (2016), pages 792 \u00e0 800<\/div>\n<div class=\"comment\">7<\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867416303440\/pdfft?md5=029f647d7c5612e240820101cd1062c1&amp;pid=1-s2.0-S0092867416303440-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref50\"><span class=\"anchor-text\">Afficher le PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867416303440\" aria-describedby=\"ref-id-sbref50\"><span class=\"anchor-text\">Voir l&#039;article<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-84965107840&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref50\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Inflammasome%20complexes%3A%20emerging%20mechanisms%20and%20effector%20functions&amp;publication_year=2016&amp;author=V.A.%20Rathinam&amp;author=K.A.%20Fitzgerald\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref50\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/div>\n<p><span class=\"reference\"><span class=\"label\">(b)<\/span><\/span><\/p>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">Q. 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R\u00e9v., 265 (1) (2015), p. 6-21,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1111\/imr.12296\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1111\/imr.12296<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-84927732725&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref53\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Regulation%20of%20inflammasome%20activation&amp;publication_year=2015&amp;author=S.M.%20Man&amp;author=T.D.%20Kanneganti\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref53\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib54\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib54\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[54]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">G. 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Immunol., 186 (11) (2011), pages 6553-6561,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.4049\/jimmunol.1100478\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.4049\/jimmunol.1100478<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-79958034097&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref57\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Pannexin-1%20is%20required%20for%20ATP%20release%20during%20apoptosis%20but%20not%20for%20inflammasome%20activation&amp;publication_year=2011&amp;author=Y.%20Qu&amp;author=S.%20Misaghi&amp;author=K.%20Newton&amp;author=L.L.%20Gilmour&amp;author=S.%20Louie&amp;author=J.E.%20Cupp&amp;author=G.R.%20Dubyak&amp;author=D.%20Hackos&amp;author=V.M.%20Dixit\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref57\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib58\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib58\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[58]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">N. 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Sci. \u00c9tats-Unis, 118 (12) (2021), article e2018024118,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1073\/pnas.2018024118\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1073\/pnas.2018024118<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85102705479&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref62\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Discovery%20of%20a%20caspase%20cleavage%20motif%20antibody%20reveals%20insights%20into%20noncanonical%20inflammasome%20function&amp;publication_year=2021&amp;author=C.W.%20Davies&amp;author=I.%20Stowe&amp;author=Q.T.%20Phung&amp;author=H.%20Ho&amp;author=C.E.%20Bakalarski&amp;author=A.%20Gupta&amp;author=Y.%20Zhang&amp;author=J.R.%20Lill&amp;author=J.%20Payandeh&amp;author=N.%20Kayagaki&amp;author=J.T.%20Koerber\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref62\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib63\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib63\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[63]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">S. 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Sci. \u00c9tats-Unis, 118 (12) (2021), article e2018024118,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1073\/pnas.2018024118\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1073\/pnas.2018024118<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85102705479&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref64\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Discovery%20of%20a%20caspase%20cleavage%20motif%20antibody%20reveals%20insights%20into%20noncanonical%20inflammasome%20function&amp;publication_year=2021&amp;author=C.W.%20Davies&amp;author=I.%20Stowe&amp;author=Q.T.%20Phung&amp;author=H.%20Ho&amp;author=C.E.%20Bakalarski&amp;author=A.%20Gupta&amp;author=Y.%20Zhang&amp;author=J.R.%20Lill&amp;author=J.%20Payandeh&amp;author=N.%20Kayagaki&amp;author=J.T.%20Koerber\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref64\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib65\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib65\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[65]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">SS Wright, SO Vasudevan, VA Rathinam<\/div>\n<div id=\"ref-id-sbref65\" class=\"title text-m\">M\u00e9canismes et cons\u00e9quences de la pyroptose non canonique m\u00e9di\u00e9e par l&#039;inflammasome<\/div>\n<\/div>\n<div class=\"host u-font-sans\">J. 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Zhuo<\/div>\n<div id=\"ref-id-sbref78\" class=\"title text-m\">LncRNA H19 initie la pyroptose microgliale et la mort neuronale en cas de l\u00e9sion d&#039;isch\u00e9mie\/reperfusion r\u00e9tinienne<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Cell Death Different., 27 (1) (2020), pp. 176-191,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1038\/s41418-019-0351-4\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1038\/s41418-019-0351-4<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Afficher le PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">Cet article est en acc\u00e8s libre.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85066260765&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref78\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=LncRNA%20H19%20initiates%20microglial%20pyroptosis%20and%20neuronal%20death%20in%20retinal%20ischemiareperfusion%20injury&amp;publication_year=2020&amp;author=P.%20Wan&amp;author=W.%20Su&amp;author=Y.%20Zhang&amp;author=Z.%20Li&amp;author=C.%20Deng&amp;author=J.%20Li&amp;author=N.%20Jiang&amp;author=S.%20Huang&amp;author=E.%20Long&amp;author=Y.%20Zhuo\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref78\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib79\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib79\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[79]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">W. 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Sci. \u00c9tats-Unis, 111 (30) (2014), pages 11181-11186,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1073\/pnas.1402819111\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1073\/pnas.1402819111<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-84904990668&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref79\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Caspase-8%20promotes%20NLRP1NLRP3%20inflammasome%20activation%20and%20IL-1%20production%20in%20acute%20glaucoma&amp;publication_year=2014&amp;author=W.%20Chi&amp;author=F.%20Li&amp;author=H.%20Chen&amp;author=Y.%20Wang&amp;author=Y.%20Zhu&amp;author=X.%20Yang&amp;author=J.%20Zhu&amp;author=F.%20Wu&amp;author=H.%20Ouyang&amp;author=J.%20Ge&amp;author=R.N.%20Weinreb&amp;author=K.%20Zhang&amp;author=Y.%20Zhuo\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref79\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib80\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib80\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[80]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">A. 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Sci. \u00c9tats-Unis, 100 (26) (2003), pages 16012-16017,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1073\/pnas.2534856100\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1073\/pnas.2534856100<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-0346103651&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref82\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Fundamental%20role%20of%20the%20Rip2caspase-1%20pathway%20in%20hypoxia%20and%20ischemia-induced%20neuronal%20cell%20death&amp;publication_year=2003&amp;author=W.H.%20Zhang&amp;author=X.%20Wang&amp;author=M.%20Narayanan&amp;author=Y.%20Zhang&amp;author=C.%20Huo&amp;author=J.C.%20Reed&amp;author=R.M.%20Friedlander\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref82\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib83\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib83\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[83]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">QZ Tuo, ST Zhang, P. 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Liang, Q. Wang, JQ Li, T. Guo, D. Yu<\/div>\n<div id=\"ref-id-sbref84\" class=\"title text-m\">L&#039;ARN long non codant MEG3 favorise les l\u00e9sions d&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale en augmentant la pyroptose en ciblant l&#039;axe miR-485\/AIM2<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Exp. 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href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85036533976&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref92\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" 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Neuroinflammation., 15 (1) (2018), p. 242,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1186\/s12974-018-1282-6\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1186\/s12974-018-1282-6<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Afficher le PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">Cet article est en acc\u00e8s libre.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85052498101&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref114\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Mitochondrial%20dysfunction%20induces%20NLRP3%20inflammasome%20activation%20during%20cerebral%20ischemiareperfusion%20injury&amp;publication_year=2018&amp;author=Z.%20Gong&amp;author=J.%20Pan&amp;author=Q.%20Shen&amp;author=M.%20Li&amp;author=Y.%20Peng\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref114\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib116\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib116\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[116]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">V. 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Cell Neurosci., 100 (2019), article 103408,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.mcn.2019.103408\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.mcn.2019.103408<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1044743119301022\/pdfft?md5=e8a7f15cbf04494465eb254154ef01e8&amp;pid=1-s2.0-S1044743119301022-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref115\"><span class=\"anchor-text\">Afficher le PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1044743119301022\" aria-describedby=\"ref-id-sbref115\"><span class=\"anchor-text\">Voir l&#039;article<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85072219892&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref115\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Mechanism%20of%20mitochondrial%20complex%20I%20damage%20in%20brain%20ischemiareperfusion%20injury.%20A%20hypothesis&amp;publication_year=2019&amp;author=V.%20Ten&amp;author=A.%20Galkin\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref115\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib117\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib117\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[117]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">S. 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Sci., 14 (12) (2013), pages 24742 \u00e0 24754,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.3390\/ijms141224742\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.3390\/ijms141224742<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-84890943680&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref123\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Necrostatin-1%20attenuates%20ischemia%20injury%20induced%20cell%20death%20in%20rat%20tubular%20cell%20line%20NRK-52E%20through%20decreased%20Drp1%20expression&amp;publication_year=2013&amp;author=L.%20Zhang&amp;author=F.%20Jiang&amp;author=Y.%20Chen&amp;author=J.%20Luo&amp;author=S.%20Liu&amp;author=B.%20Zhang&amp;author=Z.%20Ye&amp;author=W.%20Wang&amp;author=X.%20Liang&amp;author=W.%20Shi\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref123\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib125\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib125\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[125]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">Yu Chen<\/div>\n<div id=\"ref-id-sbref124\" class=\"title text-m\">Le r\u00f4le de la dynamine-1 dans le m\u00e9canisme de l&#039;hypoxie et de la pyroptose induite par la r\u00e9oxyg\u00e9nation des cellules \u00e9pith\u00e9liales des tubes r\u00e9naux humains [D]<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Troisi\u00e8me Universit\u00e9 de m\u00e9decine militaire (2016)<\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=The%20role%20of%20dynamin-1%20in%20the%20mechanism%20of%20hypoxia%20and%20reoxygenation-induced%20pyroptosis%20of%20human%20renal%20tubular%20epithelial%20cells%20D&amp;publication_year=2016&amp;author=Yu%20Chen\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref124\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib126\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib126\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[126]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">Z. Gong, J. Pan, Q. Shen, M. Li, Y. Peng<\/div>\n<div id=\"ref-id-sbref125\" class=\"title text-m\">Un dysfonctionnement mitochondrial induit l&#039;activation de l&#039;inflammasome NLRP3 lors d&#039;une l\u00e9sion d&#039;isch\u00e9mie\/reperfusion c\u00e9r\u00e9brale<\/div>\n<\/div>\n<div class=\"host u-font-sans\">J. Neuroinflammation., 15 (1) (2018), p. 242,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1186\/s12974-018-1282-6\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1186\/s12974-018-1282-6<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Afficher le PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">Cet article est en acc\u00e8s libre.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85052498101&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref125\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Mitochondrial%20dysfunction%20induces%20NLRP3%20inflammasome%20activation%20during%20cerebral%20ischemiareperfusion%20injury&amp;publication_year=2018&amp;author=Z.%20Gong&amp;author=J.%20Pan&amp;author=Q.%20Shen&amp;author=M.%20Li&amp;author=Y.%20Peng\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref125\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib127\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib127\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[127]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">T. Zhang, MT He, XP Zhang, L. Jing, JZ Zhang<\/div>\n<div id=\"ref-id-sbref126\" class=\"title text-m\">Le d\u00e9couplage du d\u00e9ficit en prot\u00e9ine 2 am\u00e9liore l&#039;activation de l&#039;inflammasome NLRP3 suite \u00e0 une exacerbation induite par l&#039;hyperglyc\u00e9mie de l&#039;isch\u00e9mie c\u00e9r\u00e9brale et des dommages de reperfusion in vitro et in vivo<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Neurochem Res, 46 (6) (2021), pages 1359-1371,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1007\/s11064-021-03270-9\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1007\/s11064-021-03270-9<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Afficher le PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">Cet article est en acc\u00e8s libre.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85102650404&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref126\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Uncoupling%20Protein%202%20Deficiency%20Enhances%20NLRP3%20Inflammasome%20Activation%20Following%20Hyperglycemia-Induced%20Exacerbation%20of%20Cerebral%20Ischemia%20and%20Reperfusion%20Damage%20In%20Vitro%20and%20In%20Vivo&amp;publication_year=2021&amp;author=T.%20Zhang&amp;author=M.T.%20He&amp;author=X.P.%20Zhang&amp;author=L.%20Jing&amp;author=J.Z.%20Zhang\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref126\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib128\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib128\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[128]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">H. Liu, X. Wu, J. Luo, L. Zhao, X. Li, H. Guo, H. Bai, W. Cui, W. Guo, D. Feng, Y. Qu<\/div>\n<div id=\"ref-id-sbref127\" class=\"title text-m\">Le peptide d&#039;adiponectine att\u00e9nue le stress oxydatif et l&#039;activation de l&#039;inflammasome NLRP3 apr\u00e8s une l\u00e9sion d&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale en r\u00e9gulant l&#039;AMPK\/GSK-3\u03b2<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Exp. Neurol., 329 (2020), article 113302,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.expneurol.2020.113302\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.expneurol.2020.113302<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014488620301333\/pdfft?md5=210c46d314c2ca971bdc8cfa5da92f97&amp;pid=1-s2.0-S0014488620301333-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref127\"><span class=\"anchor-text\">Afficher le PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014488620301333\" aria-describedby=\"ref-id-sbref127\"><span class=\"anchor-text\">Voir l&#039;article<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85083003575&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref127\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Adiponectin%20peptide%20alleviates%20oxidative%20stress%20and%20NLRP3%20inflammasome%20activation%20after%20cerebral%20ischemia-reperfusion%20injury%20by%20regulating%20AMPKGSK-3&amp;publication_year=2020&amp;author=H.%20Liu&amp;author=X.%20Wu&amp;author=J.%20Luo&amp;author=L.%20Zhao&amp;author=X.%20Li&amp;author=H.%20Guo&amp;author=H.%20Bai&amp;author=W.%20Cui&amp;author=W.%20Guo&amp;author=D.%20Feng&amp;author=Y.%20Qu\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref127\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib129\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib129\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[129]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">W. Zhu, KA Romano, L. Li, JA Buffa, N. Sangwan, P. Prakash, AN Tittle, XS Li, X. Fu, C. Androjna, AJ DiDonato, K. Brinson, BD Trapp, MA Fischbach, FE Rey, AM Hajjar, JA DiDonato, SL Hazen<\/div>\n<div id=\"ref-id-sbref128\" class=\"title text-m\">Les microbes intestinaux ont un impact sur la gravit\u00e9 des accidents vasculaires c\u00e9r\u00e9braux via la voie du N-oxyde de trim\u00e9thylamine<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Microbe h\u00f4te cellulaire, 29 (7) (2021), pages 1199-1208,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.chom.2021.05.002\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.chom.2021.05.002<\/span><\/a><\/div>\n<div class=\"comment\">Publication en ligne le 16 juin 2021. PMID\u00a0: 34139173\u00a0; PMCID\u00a0: PMC8288076<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Afficher le PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">Cet article est en acc\u00e8s libre.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85110457206&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref128\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Gut%20microbes%20impact%20stroke%20severity%20via%20the%20trimethylamine%20N-oxide%20pathway&amp;publication_year=2021&amp;author=W.%20Zhu&amp;author=K.A.%20Romano&amp;author=L.%20Li&amp;author=J.A.%20Buffa&amp;author=N.%20Sangwan&amp;author=P.%20Prakash&amp;author=A.N.%20Tittle&amp;author=X.S.%20Li&amp;author=X.%20Fu&amp;author=C.%20Androjna&amp;author=A.J.%20DiDonato&amp;author=K.%20Brinson&amp;author=B.D.%20Trapp&amp;author=M.A.%20Fischbach&amp;author=F.E.%20Rey&amp;author=A.M.%20Hajjar&amp;author=J.A.%20DiDonato&amp;author=S.L.%20Hazen\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref128\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib130\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib130\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[130]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">PM Bath, K. 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R\u00e9v., 4 (4) (2017), article CD000398,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1002\/14651858.CD000398.pub2\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1002\/14651858.CD000398.pub2<\/span><\/a><\/div>\n<div class=\"comment\">PMID\u00a0: 28429459\u00a0; PMCID\u00a0: PMC6478181.<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85018495205&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref129\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Nitric%20oxide%20donors%20%2C%20L-arginine%2C%20or%20nitric%20oxide%20synthase%20inhibitors%20for%20acute%20stroke&amp;publication_year=2017&amp;author=P.M.%20Bath&amp;author=K.%20Krishnan&amp;author=J.P.%20Appleton\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref129\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib131\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib131\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[131]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">C. Li, Z. Zhao, Y. Luo, T. Ning, P. Liu, Q. Chen, Y. Chu, Q. Guo, Y. Zhang, W. Zhou, H. Chen, Z. Zhou, Y. Wang, B. Su, H. You, T. Zhang, X. Li, H. Song, C. Li, T. Sun, C. Jiang<\/div>\n<div id=\"ref-id-sbref130\" class=\"title text-m\">Nanoparticules de dioxyde de mangan\u00e8se masqu\u00e9es par des macrophages pour la neuroprotection en r\u00e9duisant le stress oxydatif et en modulant le microenvironnement inflammatoire lors d&#039;un accident vasculaire c\u00e9r\u00e9bral isch\u00e9mique aigu<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Av. Sci. (Weinh. ), 8 (20) (2021), article e2101526,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1002\/advs.202101526\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1002\/advs.202101526<\/span><\/a><\/div>\n<div class=\"comment\">Publication en ligne le 26 ao\u00fbt 2021. PMID\u00a0: 34436822\u00a0; PMCID\u00a0: PMC8529435<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Afficher le PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">Cet article est en acc\u00e8s libre.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Macrophage-disguised%20manganese%20dioxide%20nanoparticles%20for%20neuroprotection%20by%20reducing%20oxidative%20stress%20and%20modulating%20inflammatory%20microenvironment%20in%20acute%20ischemic%20stroke&amp;publication_year=2021&amp;author=C.%20Li&amp;author=Z.%20Zhao&amp;author=Y.%20Luo&amp;author=T.%20Ning&amp;author=P.%20Liu&amp;author=Q.%20Chen&amp;author=Y.%20Chu&amp;author=Q.%20Guo&amp;author=Y.%20Zhang&amp;author=W.%20Zhou&amp;author=H.%20Chen&amp;author=Z.%20Zhou&amp;author=Y.%20Wang&amp;author=B.%20Su&amp;author=H.%20You&amp;author=T.%20Zhang&amp;author=X.%20Li&amp;author=H.%20Song&amp;author=C.%20Li&amp;author=T.%20Sun&amp;author=C.%20Jiang\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref130\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib132\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib132\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[132]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">M. Bladowski, J. Gawrys, D. Gajecki, E. Szahidewicz-Krupska, A. Sawicz-Bladowska, A. Doroszko<\/div>\n<div id=\"ref-id-sbref131\" class=\"title text-m\">R\u00f4le des plaquettes et de la biotransformation de l&#039;oxyde nitrique dans l&#039;AVC isch\u00e9mique\u00a0: une revue transversale du banc au chevet<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Oxyde. Med Cell Longev., 2020 (2020), article 2979260,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1155\/2020\/2979260\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1155\/2020\/2979260<\/span><\/a><\/div>\n<div class=\"comment\">PMID\u00a0: 32908630\u00a0; PMCID\u00a0: PMC7474795.<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85090819433&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref131\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Role%20of%20the%20platelets%20and%20nitric%20oxide%20biotransformation%20in%20ischemic%20stroke%3A%20a%20translative%20review%20from%20bench%20to%20bedside&amp;publication_year=2020&amp;author=M.%20Bladowski&amp;author=J.%20Gawrys&amp;author=D.%20Gajecki&amp;author=E.%20Szahidewicz-Krupska&amp;author=A.%20Sawicz-Bladowska&amp;author=A.%20Doroszko\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref131\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib133\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib133\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[133]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">H. 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Neuroinflammation., 16 (1) (2019), p. 121<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Afficher le PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">Cet article est en acc\u00e8s libre.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85067036552&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref139\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=NLRP3%20inflammasome%20as%20a%20potential%20treatment%20in%20ischemic%20stroke%20concomitant%20with%20diabetes&amp;publication_year=2019&amp;author=P.%20Hong&amp;author=R.N.%20Gu&amp;author=F.X.%20Li\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref139\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib141\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib141\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[141]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">F. 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Des., 26 (34) (2020), pp. 4246-4260,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.2174\/1381612826666200708133912\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.2174\/1381612826666200708133912<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85090233206&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref148\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Pathophysiology%20of%20Ischemic%20Stroke%3A%20Role%20of%20Oxidative%20Stress&amp;publication_year=2020&amp;author=S.%20Orellana-Urz%C3%BAa&amp;author=I.%20Rojas&amp;author=L.%20L%C3%ADbano&amp;author=R.%20Rodrigo\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref148\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib150\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib150\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[150]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">CD Maida, RL Norrito, M. Daidone, A. Tuttolomondo, A. Pinto<\/div>\n<div id=\"ref-id-sbref149\" class=\"title text-m\">M\u00e9canismes neuroinflammatoires dans l&#039;AVC isch\u00e9mique\u00a0: focus sur l&#039;AVC cardioembolique, son contexte et les approches th\u00e9rapeutiques<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Int J. Mol. Sci., 21 (18) (2020), p. 6454,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.3390\/ijms21186454\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.3390\/ijms21186454<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Neuroinflammatory%20Mechanisms%20in%20Ischemic%20Stroke%3A%20Focus%20on%20Cardioembolic%20Stroke%2C%20Background%2C%20and%20Therapeutic%20Approaches&amp;publication_year=2020&amp;author=C.D.%20Maida&amp;author=R.L.%20Norrito&amp;author=M.%20Daidone&amp;author=A.%20Tuttolomondo&amp;author=A.%20Pinto\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref149\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib151\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib151\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[151]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">Z. 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Okada, T. Numata, K. Sato-Numata, RZ Sabirov, H. Liu, SI Mori, S. Morishima<\/div>\n<div id=\"ref-id-sbref151\" class=\"title text-m\">R\u00f4les des canaux anioniques r\u00e9gulateurs de volume, VSOR et Maxi-Cl, dans l&#039;apoptose, la r\u00e9sistance au cisplatine, la n\u00e9crose, la mort cellulaire isch\u00e9mique, les accidents vasculaires c\u00e9r\u00e9braux et l&#039;infarctus du myocarde<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Curr. Haut. Membre, 83 (2019), pp. 205-283,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/bs.ctm.2019.03.001\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/bs.ctm.2019.03.001<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1063582319300110\/pdfft?md5=1d1791f0b9c14fcc751e4204e0df8fc4&amp;pid=1-s2.0-S1063582319300110-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref151\"><span class=\"anchor-text\">Afficher le PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1063582319300110\" aria-describedby=\"ref-id-sbref151\"><span class=\"anchor-text\">Voir l&#039;article<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85064429476&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref151\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Roles%20of%20volume-regulatory%20anion%20channels%2C%20VSOR%20and%20Maxi-Cl%2C%20in%20apoptosis%2C%20cisplatin%20resistance%2C%20necrosis%2C%20ischemic%20cell%20death%2C%20stroke%20and%20myocardial%20infarction&amp;publication_year=2019&amp;author=Y.%20Okada&amp;author=T.%20Numata&amp;author=K.%20Sato-Numata&amp;author=R.Z.%20Sabirov&amp;author=H.%20Liu&amp;author=S.I.%20Mori&amp;author=S.%20Morishima\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref151\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib153\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib153\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[153]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">Y. 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Med Cell Longev., 2017 (2017), article 8424326,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1155\/2017\/8424326\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1155\/2017\/8424326<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85016128656&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref155\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Astragaloside%20IV%20for%20experimental%20focal%20cerebral%20ischemia%3A%20preclinical%20evidence%20and%20possible%20mechanisms&amp;publication_year=2017&amp;author=H.L.%20Wang&amp;author=Q.H.%20Zhou&amp;author=M.B.%20Xu&amp;author=X.L.%20Zhou&amp;author=G.Q.%20Zheng\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref155\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib157\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib157\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[157]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">H. 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Feng<\/div>\n<div id=\"ref-id-sbref156\" class=\"title text-m\">Mort cellulaire programm\u00e9e associ\u00e9e au r\u00e9cepteur P2X7 dans la physiopathologie de l&#039;AVC h\u00e9morragique<\/div>\n<\/div>\n<div class=\"host u-font-sans\">CurrNeuropharmacol, 16 (9) (2018), pages 1282-1295,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.2174\/1570159X16666180516094500\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.2174\/1570159X16666180516094500<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span><\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85055080474&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref156\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=P2X7%20Receptor-Associated%20Programmed%20Cell%20Death%20in%20the%20Pathophysiology%20of%20Hemorrhagic%20Stroke&amp;publication_year=2018&amp;author=H.%20Zhao&amp;author=Y.%20Chen&amp;author=H.%20Feng\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref156\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib158\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib158\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[158]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">K. 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Jurajda<\/div>\n<div id=\"ref-id-sbref157\" class=\"title text-m\">Le r\u00f4le de la r\u00e9ponse inflammatoire dans la mort cellulaire programm\u00e9e associ\u00e9e \u00e0 un AVC<\/div>\n<\/div>\n<div class=\"host u-font-sans\">CurrNeuropharmacol, 16 (9) (2018), pages 1365-1374,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.2174\/1570159X16666180222155833\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.2174\/1570159X16666180222155833<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span><\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85055080999&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref157\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=The%20Role%20of%20Inflammatory%20Response%20in%20Stroke%20Associated%20Programmed%20Cell%20Death&amp;publication_year=2018&amp;author=K.%20Duris&amp;author=Z.%20Splichal&amp;author=M.%20Jurajda\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref157\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib159\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib159\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[159]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">DY Fann, EP Nickles, L. 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Schwarz, TV Arumugam<\/div>\n<div id=\"ref-id-sbref158\" class=\"title text-m\">Une interaction CD137 Ligand-CD137 est n\u00e9cessaire en cas de l\u00e9sion c\u00e9r\u00e9brale associ\u00e9e \u00e0 un inflammasome suite \u00e0 un accident vasculaire c\u00e9r\u00e9bral isch\u00e9mique<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Neuromolecular Med, 22 (4) (2020), pages 474-483,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1007\/s12017-020-08623-1\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1007\/s12017-020-08623-1<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85092632738&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref158\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=CD137%20Ligand-CD137%20interaction%20is%20required%20for%20inflammasome-associated%20brain%20injury%20following%20ischemic%20stroke&amp;publication_year=2020&amp;author=D.Y.%20Fann&amp;author=E.P.%20Nickles&amp;author=L.%20Poh&amp;author=V.%20Rajeev&amp;author=S.%20Selvaraji&amp;author=H.%20Schwarz&amp;author=T.V.%20Arumugam\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref158\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib160\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib160\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[160]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">V. 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Ther., 26 (9) (2020), pp. 925-939,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1111\/cns.13384\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1111\/cns.13384<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Afficher le PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">Cet article est en acc\u00e8s libre.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85084010416&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref164\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Caspase-1%20inhibition%20prevents%20neuronal%20death%20by%20targeting%20the%20canonical%20inflammasome%20pathway%20of%20pyroptosis%20in%20a%20murine%20model%20of%20cerebral%20ischemia&amp;publication_year=2020&amp;author=J.%20Li&amp;author=J.H.%20Hao&amp;author=D.%20Yao&amp;author=R.%20Li&amp;author=X.F.%20Li&amp;author=Z.Y.%20Yu&amp;author=X.%20Luo&amp;author=X.H.%20Liu&amp;author=M.H.%20Wang&amp;author=W.%20Wang\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref164\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib166\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib166\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[166]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">J. 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Neurol., 325 (2020), article 113139,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.expneurol.2019.113139\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.expneurol.2019.113139<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014488619302869\/pdfft?md5=c32009110f4a234e536f16bbd938c229&amp;pid=1-s2.0-S0014488619302869-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref165\"><span class=\"anchor-text\">Afficher le PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014488619302869\" aria-describedby=\"ref-id-sbref165\"><span class=\"anchor-text\">Voir l&#039;article<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85076270980&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref165\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Long%20non-coding%20RNA%20MEG3%20promotes%20cerebral%20ischemia-reperfusion%20injury%20through%20increasing%20pyroptosis%20by%20targeting%20miR-485AIM2%20axis&amp;publication_year=2020&amp;author=J.%20Liang&amp;author=Q.%20Wang&amp;author=J.Q.%20Li&amp;author=T.%20Guo&amp;author=D.%20Yu\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref165\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib167\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib167\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[167]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">D. 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Avis. Immunol., 23 (5) (2011), pages 591 \u00e0 597,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.coi.2011.07.005\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.coi.2011.07.005<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0952791511000781\/pdfft?md5=0e6bc7b6ed20c8b4763c2aaeedbf4301&amp;pid=1-s2.0-S0952791511000781-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref169\"><span class=\"anchor-text\">Afficher le PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0952791511000781\" aria-describedby=\"ref-id-sbref169\"><span class=\"anchor-text\">Voir l&#039;article<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-80053589126&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref169\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Cross-regulation%20between%20the%20IL-1IL-18%20processing%20inflammasome%20and%20other%20inflammatory%20cytokines&amp;publication_year=2011&amp;author=B.R.%20Barker&amp;author=D.J.%20Taxman&amp;author=J.P.%20Ting\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref169\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib171\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib171\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[171]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">JY Kim, J. 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Tang<\/div>\n<div id=\"ref-id-sbref172\" class=\"title text-m\">L&#039;hispiduline pr\u00e9sente des activit\u00e9s neuroprotectrices contre les l\u00e9sions de reperfusion d&#039;isch\u00e9mie c\u00e9r\u00e9brale en supprimant la pyroptose m\u00e9di\u00e9e par NLRP3<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Life Sci., 232 (2019), article 116599,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.lfs.2019.116599\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.lfs.2019.116599<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0024320519305259\/pdfft?md5=0ff6d213b67a0633229dcc5c0c9f4326&amp;pid=1-s2.0-S0024320519305259-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref172\"><span class=\"anchor-text\">Afficher le PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0024320519305259\" aria-describedby=\"ref-id-sbref172\"><span class=\"anchor-text\">Voir l&#039;article<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85068738352&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref172\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Hispidulin%20exhibits%20neuroprotective%20activities%20against%20cerebral%20ischemia%20reperfusion%20injury%20through%20suppressing%20NLRP3-mediated%20pyroptosis&amp;publication_year=2019&amp;author=P.%20An&amp;author=J.%20Xie&amp;author=S.%20Qiu&amp;author=Y.%20Liu&amp;author=J.%20Wang&amp;author=X.%20Xiu&amp;author=L.%20Li&amp;author=M.%20Tang\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref172\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib174\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib174\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[174]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">C. 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Neurosci., 69 (3) (2019), pages 411-418,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1007\/s12031-019-01370-4\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1007\/s12031-019-01370-4<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85069709852&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref173\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Effects%20of%20NLRP6%20in%20Cerebral%20IschemiaReperfusion%20%20Injury%20in%20Rats&amp;publication_year=2019&amp;author=C.%20Meng&amp;author=J.%20Zhang&amp;author=L.%20Zhang&amp;author=Y.%20Wang&amp;author=Z.%20Li&amp;author=J.%20Zhao\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref173\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib175\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib175\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[175]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">J. 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Rep., 8 (1) (2018), p. 5971,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1038\/s41598-018-24350-x\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1038\/s41598-018-24350-x<\/span><\/a><\/div>\n<div class=\"comment\">PMID\u00a0: 29654318\u00a0; PMCID\u00a0: PMC5899150.<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Afficher le PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">Cet article est en acc\u00e8s libre.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85045520722&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref189\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Inhibition%20of%20the%20NLRP3-inflammasome%20as%20a%20potential%20approach%20for%20neuroprotection%20after%20stroke&amp;publication_year=2018&amp;author=S.%20Ismael&amp;author=L.%20Zhao&amp;author=S.%20Nasoohi&amp;author=T.%20Ishrat\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref189\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib191\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib191\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[191]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">X. 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Res Commun., 529 (3) (2020), pp. 554-561,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.bbrc.2020.05.056\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.bbrc.2020.05.056<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006291X20309645\/pdfft?md5=8c05cfaed5cd8eebadcbfbb39e440900&amp;pid=1-s2.0-S0006291X20309645-mainext.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref191\"><span class=\"anchor-text\">Afficher le PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006291X20309645\" aria-describedby=\"ref-id-sbref191\"><span class=\"anchor-text\">Voir l&#039;article<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85087844924&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref191\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=TREM-1-targeting%20LP17%20attenuates%20cerebral%20ischemia-induced%20neuronal%20injury%20by%20inhibiting%20oxidative%20stress%20and%20pyroptosis&amp;publication_year=2020&amp;author=Y.B.%20Liang&amp;author=P.P.%20Song&amp;author=Y.H.%20Zhu&amp;author=J.M.%20Xu&amp;author=P.Z.%20Zhu&amp;author=R.R.%20Liu&amp;author=Y.S.%20Zhang\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref191\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib193\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib193\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[193]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">P. 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Tang<\/div>\n<div id=\"ref-id-sbref192\" class=\"title text-m\">L&#039;hispiduline pr\u00e9sente des activit\u00e9s neuroprotectrices contre les l\u00e9sions de reperfusion d&#039;isch\u00e9mie c\u00e9r\u00e9brale en supprimant la pyroptose m\u00e9di\u00e9e par NLRP3<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Life Sci., 232 (2019), article 116599,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.lfs.2019.116599\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.lfs.2019.116599<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0024320519305259\/pdfft?md5=0ff6d213b67a0633229dcc5c0c9f4326&amp;pid=1-s2.0-S0024320519305259-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref192\"><span class=\"anchor-text\">Afficher le PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0024320519305259\" aria-describedby=\"ref-id-sbref192\"><span class=\"anchor-text\">Voir l&#039;article<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85068738352&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref192\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Hispidulin%20exhibits%20neuroprotective%20activities%20against%20cerebral%20ischemia%20reperfusion%20injury%20through%20suppressing%20NLRP3-mediated%20pyroptosis&amp;publication_year=2019&amp;author=P.%20An&amp;author=J.%20Xie&amp;author=S.%20Qiu&amp;author=Y.%20Liu&amp;author=J.%20Wang&amp;author=X.%20Xiu&amp;author=L.%20Li&amp;author=M.%20Tang\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref192\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib194\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib194\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[194]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">R. 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Neuroinflammation., 17 (1) (2020), p. 330,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1186\/s12974-020-01988-x\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1186\/s12974-020-01988-x<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Afficher le PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">Cet article est en acc\u00e8s libre.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85095116758&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref193\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Low-density%20lipoprotein%20receptor%20%20regulates%20NLRP3-mediated%20neuronal%20pyroptosis%20following%20cerebral%20ischemiareperfusion%20injury&amp;publication_year=2020&amp;author=R.%20Sun&amp;author=M.%20Peng&amp;author=P.%20Xu&amp;author=F.%20Huang&amp;author=Y.%20Xie&amp;author=J.%20Li&amp;author=Y.%20Hong&amp;author=H.%20Guo&amp;author=Q.%20Liu&amp;author=W.%20Zhu\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref193\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib195\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib195\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[195]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">Y. 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R\u00e9s, 16 (6) (2021), pp. 1037-1043,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.4103\/1673-5374.300453\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.4103\/1673-5374.300453<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85097393831&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref196\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=TP53-induced%20glycolysis%20and%20apoptosis%20regulator%20alleviates%20hypoxiaischemia-induced%20microglial%20pyroptosis%20and%20ischemic%20brain%20damage&amp;publication_year=2021&amp;author=L.L.%20Tan&amp;author=X.L.%20Jiang&amp;author=L.X.%20Xu&amp;author=G.%20Li&amp;author=C.X.%20Feng&amp;author=X.%20Ding&amp;author=B.%20Sun&amp;author=Z.H.%20Qin&amp;author=Z.B.%20Zhang&amp;author=X.%20Feng&amp;author=M.%20Li\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref196\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib198\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib198\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[198]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">X. 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Neurol., 341 (2021), article 113700,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.expneurol.2021.113700\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.expneurol.2021.113700<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014488621001059\/pdfft?md5=9f920b818b5043349105718ac846350b&amp;pid=1-s2.0-S0014488621001059-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref197\"><span class=\"anchor-text\">Afficher le PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014488621001059\" aria-describedby=\"ref-id-sbref197\"><span class=\"anchor-text\">Voir l&#039;article<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85104107847&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref197\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Bone%20marrow%20mesenchymal%20stem%20cell-derived%20exosomes%20attenuate%20cerebral%20ischemia-reperfusion%20injury-induced%20neuroinflammation%20and%20pyroptosis%20by%20modulating%20microglia%20M1M2%20phenotypes&amp;publication_year=2021&amp;author=X.%20Liu&amp;author=M.%20Zhang&amp;author=H.%20Liu&amp;author=R.%20Zhu&amp;author=H.%20He&amp;author=Y.%20Zhou&amp;author=Y.%20Zhang&amp;author=C.%20Li&amp;author=D.%20Liang&amp;author=Q.%20Zeng&amp;author=G.%20Huang\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref197\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib199\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib199\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[199]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">Y. 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Sun, H. Lu, L. Lyu, P. Yang, Z. Lin, L. Li, L. Sun, D. Lu<\/div>\n<div id=\"ref-id-sbref202\" class=\"title text-m\">La gastrodine am\u00e9liore la pyroptose induite par une l\u00e9sion de reperfusion microvasculaire en r\u00e9gulant la voie NLRP3\/caspase-1<\/div>\n<\/div>\n<div class=\"host u-font-sans\">J. Physiol. Biochem, 75 (4) (2019), pages 531 \u00e0 547,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1007\/s13105-019-00702-7\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1007\/s13105-019-00702-7<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85071480099&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref202\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Gastrodin%20ameliorates%20microvascular%20reperfusion%20injury-induced%20pyroptosis%20by%20regulating%20the%20NLRP3caspase-1%20pathway&amp;publication_year=2019&amp;author=W.%20Sun&amp;author=H.%20Lu&amp;author=L.%20Lyu&amp;author=P.%20Yang&amp;author=Z.%20Lin&amp;author=L.%20Li&amp;author=L.%20Sun&amp;author=D.%20Lu\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref202\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib204\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib204\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[204]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">HS Zhang, B. Ouyang, XY Ji, MF Liu<\/div>\n<div id=\"ref-id-sbref203\" class=\"title text-m\">La gastrodine att\u00e9nue les l\u00e9sions d&#039;isch\u00e9mie\/reperfusion c\u00e9r\u00e9brale en inhibant la pyroptose en r\u00e9gulant l&#039;axe lncRNA NEAT1\/miR-22-3p<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Neurochem Res, 46 (7) (2021), pages 1747-1758,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1007\/s11064-021-03285-2\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1007\/s11064-021-03285-2<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85104117182&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref203\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Gastrodin%20Alleviates%20Cerebral%20IschaemiaReperfusion%20Injury%20by%20Inhibiting%20Pyroptosis%20by%20Regulating%20the%20lncRNA%20NEAT1miR-22-3p%20Axis&amp;publication_year=2021&amp;author=H.S.%20Zhang&amp;author=B.%20Ouyang&amp;author=X.Y.%20Ji&amp;author=M.F.%20Liu\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref203\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib205\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib205\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[205]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">Cai Lin<\/div>\n<div id=\"ref-id-sbref204\" class=\"title text-m\">Yi Xiaobo. 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R\u00e9s, 161 (2020), article 105263,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.phrs.2020.105263\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.phrs.2020.105263<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1043661820315711\/pdfft?md5=f06179b256e8e23dd685c57247f67d5e&amp;pid=1-s2.0-S1043661820315711-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref226\"><span class=\"anchor-text\">Afficher le PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1043661820315711\" aria-describedby=\"ref-id-sbref226\"><span class=\"anchor-text\">Voir l&#039;article<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85095773224&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref226\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Chemical%20constituents%20of%20Panax%20ginseng%20and%20Panax%20notoginseng%20explain%20why%20they%20differ%20in%20therapeutic%20efficacy&amp;publication_year=2020&amp;author=H.%20Liu&amp;author=X.%20Lu&amp;author=Y.%20Hu&amp;author=X.%20Fan\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref226\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib228\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib228\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[228]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">He Xu, Ge Jinwen, Deng Changqing, Guo Taiping, Pan Aihua, Li. 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Tradition. Menton. M\u00e9d. 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Tradition. Menton. M\u00e9d. 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Ethnopharmacol., 242 (2019), article 112051,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.jep.2019.112051\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.jep.2019.112051<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874119306816\/pdfft?md5=20e0d49e6cd3b78abd9bc6de80190401&amp;pid=1-s2.0-S0378874119306816-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref243\"><span class=\"anchor-text\">Afficher le PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874119306816\" aria-describedby=\"ref-id-sbref243\"><span class=\"anchor-text\">Voir l&#039;article<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85068926621&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref243\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Neuroprotective%20effect%20of%20glycosides%20in%20BuyangHuanwu%20Decoction%20on%20pyroptosis%20following%20cerebral%20ischemia-reperfusion%20injury%20in%20rats&amp;publication_year=2019&amp;author=Y.%20She&amp;author=L.%20Shao&amp;author=Y.%20Zhang&amp;author=Y.%20Hao&amp;author=Y.%20Cai&amp;author=Z.%20Cheng&amp;author=C.%20Deng&amp;author=X.%20Liu\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref243\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib245\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib245\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[245]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">Fan Junyi, Chen Yongbin, Liu Qihua, Luo Yanping, Li Nanfang, Huang Xianwen<\/div>\n<div id=\"ref-id-sbref244\" class=\"title text-m\">Effets de la d\u00e9coction de Longzhi sur l&#039;expression des prot\u00e9ines Caspase-1 et IL-18 apr\u00e8s une l\u00e9sion d&#039;isch\u00e9mie-reperfusion c\u00e9r\u00e9brale chez le rat<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Universit\u00e9 J.Hunan. 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Food Biochem., 35 (5) (2011), pages 1501-1507<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/doi.org\/10.1111\/j.1745-4514.2010.00471.x\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref251\"><span class=\"anchor-text\">R\u00e9fCross<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-80053532261&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref251\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Antioxidant%20and%20antithrombotic%20activity%20of%20tender%20coconut%20water%20in%20experimental%20myocardial%20infarction&amp;publication_year=2011&amp;author=A.%20Prathapan&amp;author=T.%20Rajamohan\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref251\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib253\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib253\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[253]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">N. 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PMID\u00a0: 21114897<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-79953137074&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref252\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Young%20coconut%20juice%2C%20a%20potential%20therapeutic%20agent%20that%20could%20significantly%20reduce%20some%20pathologies%20associated%20with%20Alzheimers%20disease%3A%20novel%20findings&amp;publication_year=2011&amp;author=N.%20Radenahmad&amp;author=F.%20Saleh&amp;author=K.%20Sawangjaroen&amp;author=U.%20Vongvatcharanon&amp;author=P.%20Subhadhirasakul&amp;author=W.%20Rundorn&amp;author=B.%20Withyachumnarnkul&amp;author=J.R.%20Connor\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref252\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib254\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib254\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[254]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">RH B\u00f6ger<\/div>\n<div id=\"ref-id-sbref253\" class=\"title text-m\">La pharmacodynamique de\u00a0<span class=\"small-caps\">L<\/span>-arginine<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Modifier. L\u00e0. Sant\u00e9 Med, 20 (3) (2014), pp. 48-54<\/div>\n<div class=\"comment\">PMID\u00a0: 24755570<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-84904062805&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref253\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=The%20pharmacodynamics%20of%20L-arginine&amp;publication_year=2014&amp;author=R.H.%20B%C3%B6ger\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref253\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib255\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib255\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[255]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">D. Cylwik, A. Mogielnicki, W. Buczko<\/div>\n<div id=\"ref-id-sbref254\" class=\"title text-m\"><span class=\"small-caps\">L<\/span>-arginine et syst\u00e8me cardiovasculaire<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Pharma. Rep., 57 (1) (2005), p. 14-22<\/div>\n<div class=\"comment\">PMID\u00a0: 15849373<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-18044377751&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref254\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=L-arginine%20and%20cardiovascular%20system&amp;publication_year=2005&amp;author=D.%20Cylwik&amp;author=A.%20Mogielnicki&amp;author=W.%20Buczko\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref254\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib256\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib256\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[256]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">D. Cylwik, A. Mogielnicki, K. Kramkowski, J. Stokowski, W. Buczko<\/div>\n<div id=\"ref-id-sbref255\" class=\"title text-m\">Effet antithrombotique de\u00a0<span class=\"small-caps\">L<\/span>-arginine chez les rats hypertendus<\/div>\n<\/div>\n<div class=\"host u-font-sans\">J. Physiol. Pharm., 55 (3) (2004), pages 563-574<\/div>\n<div class=\"comment\">PMID\u00a0: 15381827<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-4844228829&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref255\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Antithrombotic%20effect%20of%20L-arginine%20in%20hypertensive%20rats&amp;publication_year=2004&amp;author=D.%20Cylwik&amp;author=A.%20Mogielnicki&amp;author=K.%20Kramkowski&amp;author=J.%20Stokowski&amp;author=W.%20Buczko\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref255\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib257\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib257\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[257]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">SA Tanuseputero, MT Lin, SL Ouais, CL Ouais<\/div>\n<div id=\"ref-id-sbref256\" class=\"title text-m\">L&#039;administration intraveineuse d&#039;arginine r\u00e9gule \u00e0 la baisse l&#039;activit\u00e9 inflammatoire du NLRP3 et att\u00e9nue les l\u00e9sions r\u00e9nales aigu\u00ebs chez les souris atteintes de sepsis polymicrobien<\/div>\n<\/div>\n<div class=\"host u-font-sans\">M\u00e9diat. Inflamm., 2020 (2020), article 3201635,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1155\/2020\/3201635\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1155\/2020\/3201635<\/span><\/a><\/div>\n<div class=\"comment\">PMID\u00a0: 32454788\u00a0; PMCID\u00a0: PMC7238342.<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Voir l&#039;article<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85085510204&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref256\"><span class=\"anchor-text\">Afficher dans Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Intravenous%20Arginine%20Administration%20Downregulates%20NLRP3%20inflammasome%20activity%20and%20attenuates%20acute%20kidney%20injury%20in%20mice%20with%20polymicrobial%20sepsis&amp;publication_year=2020&amp;author=S.A.%20Tanuseputero&amp;author=M.T.%20Lin&amp;author=S.L.%20Yeh&amp;author=C.L.%20Yeh\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref256\"><span class=\"anchor-text\">Google Scholar<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<\/ol>\n<\/section>\n<\/section>\n<div id=\"section-cited-by\">\n<section class=\"ListArticles preview\" aria-label=\"Cit\u00e9 par\">\n<div class=\"PageDivider\"><\/div>\n<header id=\"citing-articles-header\">\n<h2 class=\"u-h4 u-margin-l-ver u-font-serif\">Cit\u00e9 par (7)<\/h2>\n<\/header>\n<div aria-describedby=\"citing-articles-header\">\n<div class=\"citing-articles u-margin-l-bottom\">\n<ul>\n<li class=\"ListArticleItem u-margin-l-bottom\">\n<div 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Place de la Recherche<\/div>\n<\/div>\n<div class=\"buttons text-s\"><\/div>\n<\/li>\n<li class=\"ListArticleItem u-margin-l-bottom\">\n<div class=\"sub-heading u-margin-xs-bottom\">\n<p id=\"citing-articles-article-3-title\" class=\"u-font-serif\"><a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1002\/ptr.7994\" target=\"_blank\" rel=\"noopener\"><span class=\"anchor-text\">Avanc\u00e9es de la phytoth\u00e9rapie dans l\u2019AVC isch\u00e9mique ciblant la signalisation PI3K\/Akt<\/span><\/a><\/p>\n<div class=\"text-s\">2023, Recherche en Phytoth\u00e9rapie<\/div>\n<\/div>\n<div class=\"buttons text-s\"><\/div>\n<\/li>\n<\/ul>\n<\/div>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889\">Source<\/a><\/p>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>This suggests that breviscapine may significantly improve the cognitive function of CCI rats and reduce the pathological damage of ischemic neurons, and its mechanism may be related to the inhibition of NLRP3 inflammasome activation and pyroptosis pathway in brain tissue [211].<\/p>","protected":false},"author":1,"featured_media":5371,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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