{"id":4869,"date":"2024-01-15T06:14:20","date_gmt":"2024-01-15T06:14:20","guid":{"rendered":"https:\/\/corp.farlong.com\/phytochemical-screening-and-biological-evaluation-of-greek-sage-salvia-fruticosa-mill-extracts\/"},"modified":"2024-11-14T17:08:47","modified_gmt":"2024-11-14T17:08:47","slug":"phytochemical-screening-and-biological-evaluation-of-greek-sage-salvia-fruticosa-mill-extracts","status":"publish","type":"post","link":"https:\/\/directcm.com\/ja\/phytochemical-screening-and-biological-evaluation-of-greek-sage-salvia-fruticosa-mill-extracts\/","title":{"rendered":"\u30ae\u30ea\u30b7\u30e3\u30bb\u30fc\u30b8 (Salvia fruticosa Mill.) \u62bd\u51fa\u7269\u306e\u690d\u7269\u5316\u5b66\u7684\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3068\u751f\u7269\u5b66\u7684\u8a55\u4fa1"},"content":{"rendered":"

LC-Q-Orbitrap HRMS \u3092\u4f7f\u7528\u3057\u305f\u30e1\u30bf\u30dc\u30ed\u30fc\u30e0 \u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0<\/span><\/p>\n

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\u56f31<\/b><\/figcaption>
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\"figure<\/picture><\/a><\/div>\n
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\u30cd\u30ac\u30c6\u30a3\u30d6 \u30e2\u30fc\u30c9\u306e LC-Q-Orbitrap \u306b\u3088\u3063\u3066\u53d6\u5f97\u3055\u308c\u305f\u30c8\u30fc\u30bf\u30eb \u30a4\u30aa\u30f3 \u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30e0 (\u9ed2) \u3068\u3001270 nm \u3067 UV-Vis \u691c\u51fa\u5668\u306b\u3088\u3063\u3066\u8a18\u9332\u3055\u308c\u305f\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30e0 (\u30aa\u30ec\u30f3\u30b8) \u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u3082\u306e\u3042\u308b<\/b>\uff09\u30014\u3064\u306e\u7570\u306a\u308b\u30b9\u30da\u30af\u30c8\u30eb\u306b\u304a\u3051\u308b\u540c\u5b9a\u3055\u308c\u305f\u5316\u5408\u7269\u306e\u5e73\u5747MS\u30d4\u30fc\u30af\u9762\u7a4d\u5024\u3092\u8868\u3059\u30d2\u30fc\u30c8\u30de\u30c3\u30d7\u304c\u8a2d\u5b9a\u3055\u308c\u3066\u3044\u308b\u3002 S.\u30d5\u30eb\u30c6\u30a3\u30b3\u30b5<\/i> \u629c\u7c8b: SFH2<\/sub>O \u2013 \u6c34\u62bd\u51fa\u7269\u3002 SF30-30% \u30a8\u30bf\u30ce\u30fc\u30eb\u62bd\u51fa\u7269; SF70-70% \u30a8\u30bf\u30ce\u30fc\u30eb\u62bd\u51fa\u7269; SF100 \u2013 \u30a8\u30bf\u30ce\u30fc\u30eb\u62bd\u51fa\u7269 (b<\/b>\uff09\u3002\u30d4\u30fc\u30af\u306e\u6b63\u4f53\u306b\u3064\u3044\u3066\u306f\u3001\u88dc\u8db3\u8868\u3092\u53c2\u7167\u3057\u3066\u304f\u3060\u3055\u3044\u3002 S1<\/a>.<\/p>\n<\/div>\n<\/div>\n<\/figure>\n<\/div>\n

2 \u3064\u306e\u6700\u3082\u6975\u6027\u306e\u9ad8\u3044\u62bd\u51fa\u7269 (SFH) \u306e\u5834\u54082<\/sub>O\u304a\u3088\u3073SF30\uff09\u3067\u306f\u3001\u30d5\u30a7\u30ce\u30fc\u30eb\u9178\u304c\u30d4\u30fc\u30af\u9762\u7a4d\u5168\u4f53\u3067\u6700\u3082\u8c4a\u5bcc\u306a\u30af\u30e9\u30b9\u3067\u3042\u3063\u305f\u3002\u3053\u306e\u30af\u30e9\u30b9\u306f\u4e3b\u306b\u30ab\u30d5\u30a7\u9178\u8a98\u5c0e\u4f53\u306b\u3088\u3063\u3066\u4ee3\u8868\u3055\u308c\u305f\u3002\u5316\u5408\u7269\u306e\u4fdd\u6301\u6642\u9593\uff08RT\uff09\u306f 16<\/b> \u524d\u99c6\u4f53\u30a4\u30aa\u30f3 [MH]\uffe3 \u3092\u4f7f\u7528 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 179.03419 \u306f\u30b3\u30fc\u30d2\u30fc\u9178\u6a19\u6e96\u306e RT \u3068\u4e00\u81f4\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u7279\u5fb4\u7684\u306a\u4e3b\u8981\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u3082\u751f\u6210\u3055\u308c\u307e\u3057\u305f\u3002 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 135.04414\u3001\u4e8c\u9178\u5316\u70ad\u7d20\u306e\u640d\u5931\u306b\u3088\u308b\u3002\u5316\u5408\u7269\u4e2d\u306b\u8131\u30d7\u30ed\u30c8\u30f3\u5316\u3055\u308c\u305f\u5f62\u306e\u30b3\u30fc\u30d2\u30fc\u9178\u304c\u691c\u51fa\u3055\u308c\u307e\u3057\u305f 40<\/b> \u305d\u3057\u3066 41<\/b>\u3001\u30b5\u30b2\u30ea\u30f3\u9178\uff08[MH]\u00af\uff09\u3067\u3042\u308b\u3068\u540c\u5b9a\u3055\u308c\u305f\u3002 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 719.16210) \u304a\u3088\u3073\u30ed\u30ba\u30de\u30ea\u30f3\u9178 ([MH]\uffe3 at) \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 359.0773\uff09\u3002\u30ed\u30ba\u30de\u30ea\u30f3\u9178\u306e\u540c\u5b9a\u306f\u3001\u6a19\u6e96\u7269\u8cea\u3068\u306e\u6bd4\u8f03\u306b\u3088\u3063\u3066\u3055\u3089\u306b\u78ba\u8a8d\u3055\u308c\u305f\u3002\u540c\u3058\u30a4\u30aa\u30f3\u307e\u305f\u306f\u305d\u306e\u640d\u5931\u304c\u3001\u5316\u5408\u7269\u3067\u89b3\u5bdf\u3055\u308c\u305f\u3002 20<\/b>, 37<\/b>, 39<\/b>, 44<\/b>, 53<\/b>, 57<\/b> \u305d\u3057\u3066 58<\/b>\u3001\u6587\u732e\u304a\u3088\u3073 MS \u3068\u306e\u6bd4\u8f03\u306b\u3088\u3063\u3066\u88cf\u4ed8\u3051\u3089\u308c\u307e\u3057\u305f\u30022<\/sup> \u65ad\u7247\u5316\u306f\u30b5\u30eb\u30d3\u30a2\u30d5\u30e9\u30b7\u30c9\uff08[MH]\u00af\uff09\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u305f\u3002 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 521.13012\uff09\u3001\u30b5\u30eb\u30d3\u30a2\u30ce\u30fc\u30eb\u9178B\uff08[MH]\u00af at \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 717.14661\uff09\u3001\u30a4\u30bd\u30b5\u30eb\u30d3\u30a2\u30ce\u30fc\u30eb\u9178B\uff08[MH]\u00af at \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 717.14667)\u3001\u30b5\u30eb\u30d3\u30a2\u30ce\u30fc\u30eb\u9178 K ([MH]\uffe3 at \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 555.11469)\u30012 \u3064\u306e\u30b5\u30eb\u30d3\u30a2\u30ce\u30fc\u30eb\u9178 F \u7570\u6027\u4f53 ([MH]\uffe3 at \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 313.07205\uff09\u304a\u3088\u3073\u30b5\u30eb\u30d3\u30a2\u30ce\u30fc\u30eb\u9178C\uff08[MH]\u00af at \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 491.09863).<\/p>\n

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\u3092\u5360\u3081\u305f\u3002\u3053\u306e\u30af\u30e9\u30b9\u306f\u4e3b\u306b\u30b8\u30c6\u30eb\u30da\u30ce\u30a4\u30c9\u306b\u3088\u3063\u3066\u8868\u3055\u308c\u3001\u7814\u7a76\u3055\u308c\u305f\u62bd\u51fa\u7269\u3067\u7279\u5b9a\u3055\u308c\u305f\u6700\u3082\u591a\u69d8\u306a\u975e\u6975\u6027\u30af\u30e9\u30b9\u306e\u5316\u5408\u7269\u3067\u3042\u3063\u305f\u3002\u305d\u308c\u3089\u306f\u4e3b\u306b\u30a2\u30d3\u30a8\u30bf\u30f3\u578b\u30b8\u30c6\u30eb\u30da\u30ce\u30a4\u30c9\u3067\u3042\u308a\u3001\u8ca0\u30a4\u30aa\u30f3\u5316\u306b\u3088\u308b\u65ad\u7247\u5316\u306b\u306f\u3001\u591a\u304f\u306e\u5834\u5408 CO \u306e\u9664\u53bb\u304c\u542b\u307e\u308c\u308b\u30022<\/sub> (-44 Da)\u3001CO (-28 Da)\u3001H2<\/sub>O (-18 Da)\u3001\u00b7CH3<\/sub> (15Da)\u3002\u5316\u5408\u7269 59<\/b> ([MH]\uffe3 \u3067 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 345.17075\uff09\u304a\u3088\u3073 64<\/b> ([MH]\uffe3 \u3067 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 345.17100\uff09\u306f\u4e21\u65b9\u3068\u3082\u4e8c\u9178\u5316\u70ad\u7d20\u5206\u5b50\u306e\u640d\u5931\u306b\u8d77\u56e0\u3059\u308b\u30a4\u30aa\u30f3\u3092\u793a\u3057\u305f\uff08\u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 301.18097) \u3068\u6c34\u5206\u5b50 (\u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 283.17038 \u304a\u3088\u3073 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 283.17041)\u3001\u30ed\u30b9\u30de\u30ce\u30fc\u30eb\u304a\u3088\u3073\u30a8\u30d4\u30a4\u30bd\u30ed\u30b9\u30de\u30ce\u30fc\u30eb\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u30b3\u30f3\u30d1\u30a6\u30f3\u30c9 69<\/b> ([MH]\uffe3 \u3067 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 329.17580)\u306f\u3001\u4e8c\u9178\u5316\u70ad\u7d20\u306e\u640d\u5931\u304b\u3089\u59cb\u307e\u308b\u5178\u578b\u7684\u306a\u65ad\u7247\u5316\u30d1\u30bf\u30fc\u30f3\u306b\u57fa\u3065\u3044\u3066\u30ab\u30eb\u30ce\u30bd\u30eb\u3067\u3042\u308b\u3068\u7279\u5b9a\u3055\u308c\u307e\u3057\u305f\uff08\u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 285.16604)12<\/a>,15<\/a><\/sup> \u7d9a\u3044\u3066\u30e1\u30c1\u30eb\u30e9\u30b8\u30ab\u30eb\uff08\u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 270.16211\uff09\u3002\u540c\u3058\u65ad\u7247\u5316\u30d1\u30bf\u30fc\u30f3\u304c\u5316\u5408\u7269 80,<\/b> 12-\u30e1\u30c8\u30ad\u30b7\u30ab\u30eb\u30ce\u30b7\u30f3\u9178 ([MH]\uffe3 \u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u308b) \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 345.20721\uff09\u3068301.21689\u304a\u3088\u3073286.19385\u306e\u65ad\u7247\u304b\u3089\u306a\u308b\u5316\u5408\u7269\u3002 78<\/b>\u3001\u64ec\u4f3c\u5206\u5b50\u30a4\u30aa\u30f3\u3092\u542b\u3080 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 331.19153 [MH]\u00af\u306f\u3001\u4e8c\u9178\u5316\u70ad\u7d20\u306e\u55aa\u5931\u3068\u305d\u308c\u306b\u7d9a\u304f\u30a4\u30bd\u30d7\u30ed\u30d4\u30eb\u30e9\u30b8\u30ab\u30eb\u306e\u55aa\u5931\u306b\u5bfe\u5fdc\u3059\u308b\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u306e\u5b58\u5728\u306b\u3088\u308a\u3001\u30ab\u30eb\u30ce\u30b7\u30f3\u9178\u3067\u3042\u308b\u3068\u540c\u5b9a\u3055\u308c\u305f\uff08\u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 287.20175 \u304a\u3088\u3073 244.14687\uff09\u3002\u30b3\u30f3\u30d1\u30a6\u30f3\u30c9 70<\/b> [MH]\u00af\u3067\u524d\u99c6\u30a4\u30aa\u30f3\u3092\u793a\u3057\u305f \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 343.15524\u3001\u7279\u5fb4\u7684\u306a\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u3092\u751f\u6210 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 315.16028 \u304a\u3088\u3073 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> \u305d\u308c\u305e\u308c\u30a8\u30c1\u30ec\u30f3\u3068\u4e8c\u9178\u5316\u70ad\u7d20\u306e\u640d\u5931\u306b\u3088\u308a299.160504\u3002\u305d\u308c\u306b\u3088\u308a\u5316\u5408\u7269\u3092\u7279\u5b9a\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059 70<\/b> \u30ed\u30b9\u30de\u30b8\u30a2\u30eb\u3068\u3057\u3066\u3002\u8a66\u9a13\u3057\u305f\u62bd\u51fa\u7269\u306b\u306f\u30012\u3064\u306e\u4e94\u74b0\u5f0f\u30c8\u30ea\u30c6\u30eb\u30da\u30ce\u30a4\u30c9\u3082\u691c\u51fa\u3055\u308c\u305f\uff1a\u5316\u5408\u7269 96<\/b> \u305d\u3057\u3066 97<\/b>\u3001\u3053\u308c\u3089\u306f\u66ab\u5b9a\u7684\u306b\u305d\u308c\u305e\u308c\u30d9\u30c4\u30ea\u30f3\u9178\u3068\u30a6\u30eb\u30bd\u30fc\u30eb\u9178\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u3001([MH]\uffe3 \u3067\u6e96\u5206\u5b50\u30a4\u30aa\u30f3\u3092\u6301\u3064) \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 455.35340\uff09\u3002\u3053\u308c\u3089\u306e\u30c8\u30ea\u30c6\u30eb\u30da\u30ce\u30a4\u30c9\u306e\u5b58\u5728\u306f\u3001\u6b21\u306e\u6587\u732e\u3067\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 S.\u30d5\u30eb\u30c6\u30a3\u30b3\u30b5<\/i> Jash \u3089\u306b\u3088\u308b16<\/a><\/sup>.<\/p>\n

\u7814\u7a76\u3055\u308c\u305f\u62bd\u51fa\u7269\u3001\u7279\u306b\u6c34\u5206\u542b\u6709\u91cf\u306e\u9ad8\u3044\u62bd\u51fa\u7269 (SFH)2<\/sub>O\u3001SF30\uff09\u3001\u540c\u5b9a\u3055\u308c\u305f\u5316\u5408\u7269\u306e\u7dcf\u30d4\u30fc\u30af\u9762\u7a4d\u306b\u304a\u3051\u308b\u30aa\u30ea\u30b4\u7cd6\u3068\u7cd6\u9178\u306e\u5927\u304d\u306a\u5272\u5408\u3082\u78ba\u8a8d\u3055\u308c\u305f\u3002\u5316\u5408\u7269 1<\/b>, 2<\/b> \u305d\u3057\u3066 3<\/b> \u30b9\u30bf\u30ad\u30aa\u30fc\u30b9\u3001\u30e9\u30d5\u30a3\u30ce\u30fc\u30b9\u3001\u30b9\u30af\u30ed\u30fc\u30b9\u3068\u66ab\u5b9a\u7684\u306b\u540c\u5b9a\u3055\u308c\u305f\u304c\u3001\u3053\u308c\u3089\u306f\u3057\u3070\u3057\u3070\u4e3b\u8981\u306a\u8f38\u9001\u7cd6\u3067\u3042\u308b\u3002 \u30b5\u30eb\u30d3\u30a2<\/i> \u7a2e31<\/a><\/sup>. \u5316\u5408\u7269 4\uff5e8\u6b73<\/b> \u7cd6\u9178\u3068\u3057\u3066\u5206\u985e\u3055\u308c\u305f\u3002\u5316\u5408\u7269\u306e\u65ad\u7247\u5316\u30d1\u30bf\u30fc\u30f3 6<\/b> ([MH]\uffe3 \u3067 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 135.02875\uff09\u306f\u3001 l<\/span>-\u30c8\u30ec\u30aa\u30f3\u9178\u3002\u5316\u5408\u7269 8<\/b> ([MH]\uffe3 \u3067 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 149.0081) \u751f\u6210\u3055\u308c\u305f\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 72.99171\u300159.01249\u3001\u304a\u3088\u3073 87.00734 \u306f\u3001\u30de\u30a4\u30ca\u30b9\u30a4\u30aa\u30f3\u5316\u30e2\u30fc\u30c9\u3067\u89b3\u5bdf\u3067\u304d\u307e\u3059\u3002 l<\/span>-(+)-\u9152\u77f3\u9178\u3002<\/p>\n

\u691c\u51fa\u3055\u308c\u305f\u690d\u7269\u5316\u5b66\u7269\u8cea\u306e\u3082\u3046\u4e00\u3064\u306e\u4e3b\u8981\u306a\u30af\u30e9\u30b9\u306f S.\u30d5\u30eb\u30c6\u30a3\u30b3\u30b5<\/i> \u62bd\u51fa\u7269\u306f\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u3067\u3057\u305f\u3002\u3053\u306e\u30af\u30e9\u30b9\u306b\u5c5e\u3059\u308b\u5316\u5408\u7269\u306e\u307b\u3068\u3093\u3069\u306f\u30d5\u30e9\u30dc\u30f3\u306b\u5272\u308a\u5f53\u3066\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u5316\u5408\u7269 24<\/b> \u4fdd\u6301\u6642\u9593\u3001UV\u30b9\u30da\u30af\u30c8\u30eb\u3001MS\/MS\u30d5\u30e9\u30b0\u30e1\u30f3\u30c6\u30fc\u30b7\u30e7\u30f3\u30d1\u30bf\u30fc\u30f3\u3092\u5e02\u8ca9\u306e\u6a19\u6e96\u7269\u8cea\u3068\u6bd4\u8f03\u3059\u308b\u3053\u3068\u3067\u3001\u30b9\u30af\u30c6\u30e9\u30ea\u30f3\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u78ba\u306b\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u5316\u5408\u7269 46<\/b> \u305d\u3057\u3066 55<\/b> \u3067\u307b\u307c\u540c\u3058\u524d\u99c6\u4f53\u30a4\u30aa\u30f3 [MH]\uffe3 \u3092\u793a\u3057\u307e\u3057\u305f\u3002 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 299.0563 \u3068 299.0562\u3002\u30b3\u30f3\u30d1\u30a6\u30f3\u30c9 46<\/b> \u3067\u6700\u3082\u8c4a\u5bcc\u306a\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u304c\u751f\u6210\u3055\u308c\u307e\u3057\u305f \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 284.03253\u3068136.98682\u3001\u540c\u69d8\u306b\u8907\u5408 55<\/b>\u3002\u3053\u308c\u3089\u306e\u30c7\u30fc\u30bf\u306f\u3001\u30d2\u30b9\u30d4\u30c9\u30a5\u30ea\u30f3\u307e\u305f\u306f\u30b8\u30aa\u30b9\u30e1\u30c1\u30f3\u306e\u65ad\u7247\u5316\u30d1\u30bf\u30fc\u30f3\u3068\u4e00\u81f4\u3057\u307e\u3059\u3002\u4fdd\u6301\u6642\u9593\u306b\u9055\u3044\u304c\u3042\u308b\u305f\u3081\u3001\u4e21\u65b9\u306e\u5316\u5408\u7269\u304c\u5b58\u5728\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 S.\u30d5\u30eb\u30c6\u30a3\u30b3\u30b5<\/i> \u629c\u7c8b\u3057\u307e\u3059\u3002\u30b3\u30f3\u30d1\u30a6\u30f3\u30c9 49<\/b> [MH]\u00af\u3067\u524d\u99c6\u30a4\u30aa\u30f3\u3092\u793a\u3057\u305f \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 285.04065\u306f\u3001\u7279\u5b9a\u306e\u751f\u6210\u7269\u30a4\u30aa\u30f3\u3092\u5f62\u6210\u3057\u305f\u3002 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 133.02834\u3001151.00261\u3001175.03903\u3001Velamuri\u3089\u306b\u3088\u3063\u3066\u30eb\u30c6\u30aa\u30ea\u30f3\u306b\u3064\u3044\u3066\u5831\u544a\u3055\u308c\u305f\u3082\u306e\u3068\u4e00\u81f4\u3057\u3066\u3044\u307e\u3059\u300217<\/a><\/sup>. \u8907\u5408\u8a9e 52<\/b> ([MH]\uffe3 \u3067 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 327.21786\uff09\u306f\u3001\u3053\u306e\u30d5\u30e9\u30dc\u30f3\u304c\u4ee5\u524d\u306b\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u30b5\u30eb\u30d3\u30b2\u30cb\u30f3\uff08\u30da\u30af\u30c8\u30ea\u30ca\u30ea\u30b2\u30cb\u30f3-7-\u30e1\u30c1\u30eb\u30a8\u30fc\u30c6\u30eb\uff09\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002 S.\u30d5\u30eb\u30c6\u30a3\u30b3\u30b5<\/i>. \u8907\u5408\u8a9e 54<\/b> \u30d9\u30fc\u30b9\u30d4\u30fc\u30af[MH]\u00af\u306f \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 269.04578. \u524d\u99c6\u4f53\u30a4\u30aa\u30f3\u3068\u751f\u6210\u7269\u30a4\u30aa\u30f3 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 117.03332 \u304a\u3088\u3073 151.00264 \u306b\u3088\u308a\u3001\u3053\u306e\u5316\u5408\u7269\u304c\u30a2\u30d4\u30b2\u30cb\u30f3\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u30b3\u30f3\u30d1\u30a6\u30f3\u30c9 56<\/b> \u524d\u99c6\u4f53\u30a4\u30aa\u30f3[MH]\u00af\u3092 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 329.0668\u3001\u305d\u306e\u5206\u5b50\u5f0f\u306f C \u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u305917<\/sub>H14<\/sub>\u25cb7<\/sub>\u3002\u305d\u308c\u306f\u9855\u8457\u306a\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u30a4\u30aa\u30f3\u3092\u751f\u6210\u3057\u307e\u3057\u305f \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 299.01981\u306f2\u3064\u306e\u30e1\u30c1\u30eb\u57fa\u306e\u55aa\u5931\u306b\u8d77\u56e0\u3057\u3001271.02472\u306f\u4e00\u9178\u5316\u70ad\u7d20\u306e\u3055\u3089\u306a\u308b\u9664\u53bb\u306b\u8d77\u56e0\u3057\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u3053\u306e\u30d4\u30fc\u30af\u306f\u30b8\u30e3\u30bb\u30aa\u30b7\u30b8\u30f3\u3067\u3042\u308b\u3068\u7279\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u5316\u5408\u7269 60<\/b> \u524d\u99c6\u30a4\u30aa\u30f3[MH]\u00af\u306b\u57fa\u3065\u3044\u3066\u30b7\u30b9\u30de\u30ea\u30c1\u30f3\u3068\u540c\u5b9a\u3055\u308c\u305f\u3002 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 313.07190 \u304a\u3088\u3073\u8a3a\u65ad\u88fd\u54c1\u30a4\u30aa\u30f3\u306f\u6b21\u306e\u3068\u304a\u308a\u3067\u3059\u3002 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 298.04694 \u3068 283.02478 \u306f\u3001\u4e00\u9178\u5316\u70ad\u7d20\u306e\u9664\u53bb\u306b\u3088\u308b 2 \u3064\u306e\u30e1\u30c1\u30eb\u30e9\u30b8\u30ab\u30eb\u3068 255.02974 \u306e\u640d\u5931\u3092\u793a\u3057\u307e\u3059\u3002\u30b3\u30f3\u30d1\u30a6\u30f3\u30c9 62<\/b> ([MH]\uffe3 \u3067 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 283.06137\uff09\u306f\u3001\u30a2\u30d4\u30b2\u30cb\u30f3\u8a98\u5c0e\u4f53\u306b\u76f8\u5f53\u3059\u308b\u3002 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 268.03772 \u304a\u3088\u3073 117.03318\u3002\u7279\u5fb4\u7684\u306a\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u30a4\u30aa\u30f3 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 240.04193\u306f\u4e00\u9178\u5316\u70ad\u7d20\u306e\u640d\u5931\u306b\u3088\u308a\u5f62\u6210\u3055\u308c\u3001\u5316\u5408\u7269\u304c\u751f\u6210\u3055\u308c\u308b 62<\/b> \u30b2\u30f3\u30af\u30ef\u30cb\u30f3\u3068\u540c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u30a2\u30d4\u30b2\u30cb\u30f3\u3001\u30d2\u30b9\u30d4\u30c9\u30ea\u30f3\u3001\u30b7\u30eb\u30b7\u30de\u30ea\u30c1\u30f3\u3001\u30b2\u30f3\u30af\u30ef\u30cb\u30f3\u306e\u65ad\u7247\u5316\u30d1\u30bf\u30fc\u30f3\u306f\u3001Koutsoulas \u3089\u306b\u3088\u3063\u3066\u5831\u544a\u3055\u308c\u305f\u3082\u306e\u3068\u4e00\u81f4\u3057\u307e\u3057\u305f\u300212<\/a><\/sup>. \u8907\u5408\u8a9e 50<\/b> \u7814\u7a76\u3055\u308c\u305f\u62bd\u51fa\u7269\u3067\u691c\u51fa\u3055\u308c\u305f\u552f\u4e00\u306e\u7a2e\u985e\u306e\u30d5\u30e9\u30dc\u30ce\u30fc\u30eb \u30a2\u30b0\u30ea\u30b3\u30f3\u3067\u3057\u305f\u3002\u30d7\u30ea\u30ab\u30fc\u30b5\u30fc\u30a4\u30aa\u30f3 [MH]\uffe3 \u3092\u4f7f\u7528\u3059\u308b\u3068\u3001 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 315.0513 \u304a\u3088\u3073\u4e3b\u8981\u306a MS\/MS \u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u306f\u6b21\u306e\u3068\u304a\u308a\u3067\u3059\u3002 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> \u30e1\u30c1\u30eb\u57fa\u306e\u55aa\u5931\u304b\u3089\u751f\u3058\u308b 300.02756 \u304b\u3089\u3001\u3053\u306e\u5316\u5408\u7269\u306f\u30a4\u30bd\u30e9\u30e0\u30cd\u30c1\u30f3\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u30b3\u30f3\u30d1\u30a6\u30f3\u30c9 30<\/b> \u64ec\u4f3c\u5206\u5b50\u30a4\u30aa\u30f3 [MH]\uffe3 \u3092\u4f7f\u7528\u3057\u3066 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 609.18329 \u3067\u306f\u65ad\u7247\u5316\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u4ee5\u524d\u306b\u5831\u544a\u3055\u308c\u3066\u3044\u305f\u305f\u3081\u3001 S.\u30d5\u30eb\u30c6\u30a3\u30b3\u30b5<\/i>18<\/a>,19<\/a><\/sup>\u3001\u305d\u308c\u306f\u66ab\u5b9a\u7684\u306b\u30d5\u30e9\u30d0\u30ce\u30f3\u30d8\u30b9\u30da\u30ea\u30b8\u30f3\u3067\u3042\u308b\u3068\u540c\u5b9a\u3055\u308c\u305f\u3002\u3053\u306e\u7814\u7a76\u3067\u767a\u898b\u3055\u308c\u305f\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u914d\u7cd6\u4f53\u306f\u3001\u4e3b\u306b162 Da\u306e\u7279\u5fb4\u7684\u306a\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u3092\u6301\u3064\u914d\u7cd6\u4f53\u3001\u30b0\u30eb\u30af\u30ed\u30cb\u30c9\uff08176 Da\uff09\u3001\u304a\u3088\u3073\u30eb\u30c1\u30ce\u30b7\u30c9\uff08308 Da\uff09\u3067\u3042\u3063\u305f\u3002\u30eb\u30c6\u30aa\u30ea\u30f3\u914d\u7cd6\u4f53\uff08\u5316\u5408\u7269 22<\/b> [MH]\u00af\u3067 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 447.09344) \u306e\u5316\u5b66\u7d44\u6210\u306b\u95a2\u3059\u308b\u307b\u3068\u3093\u3069\u306e\u51fa\u7248\u7269\u306b\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002 S.\u30d5\u30eb\u30c6\u30a3\u30b3\u30b5<\/i> \u629c\u7c8b12<\/a>,18<\/a>,19<\/a>,20<\/a>,21<\/a><\/sup>. \u8907\u5408\u8a9e 26<\/b> \u3067\u524d\u99c6\u4f53\u30a4\u30aa\u30f3 [MH]\uffe3 \u3092\u793a\u3057\u307e\u3057\u305f\u3002 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 491.0836\u3067\u3042\u308a\u3001\u30a4\u30bd\u30e9\u30e0\u30cd\u30c1\u30f3\u30b0\u30eb\u30af\u30ed\u30cb\u30c9\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u3001\u4ee5\u524d\u306b\u5831\u544a\u3055\u308c\u305f\u3002 S.\u30d5\u30eb\u30c6\u30a3\u30b3\u30b5<\/i> G\u00fcrb\u00fcz\u3089\u306b\u3088\u308b\u3082\u306e\u306e\u307f\u300222<\/a><\/sup>. \u8907\u5408\u8a9e 27 (<\/b>[MH]\uffe3\u3067 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 577.15668\uff09\u3001\u30a2\u30d4\u30b2\u30cb\u30f3-\u30eb\u30c1\u30ce\u30b7\u30c9\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u305f\u3082\u306e\u306f\u3001Cvetkovik\u3089\u306b\u3088\u3063\u3066\u30ae\u30ea\u30b7\u30e3\u306e\u30bb\u30fc\u30b8\u304b\u3089\u3082\u767a\u898b\u3055\u308c\u307e\u3057\u305f\u300221<\/a><\/sup>.<\/p>\n

\u8102\u80aa\u9178\u306e\u5b58\u5728\u3082\u89b3\u5bdf\u3055\u308c\u305f\u3002 S.\u30d5\u30eb\u30c6\u30a3\u30b3\u30b5<\/i> \u62bd\u51fa\u7269\u3002\u5316\u5408\u7269 63<\/b> \u305d\u3057\u3066 73<\/b> \u66ab\u5b9a\u7684\u306b 2 \u3064\u306e\u591a\u4fa1\u4e0d\u98fd\u548c\u8102\u80aa\u9178\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u30b3\u30f3\u30d1\u30a6\u30f3\u30c9 63<\/b> \u30b8\u30d2\u30c9\u30ed\u30ad\u30b7\u30aa\u30af\u30bf\u30c7\u30ab\u30b8\u30a8\u30f3\u9178\uff08C18<\/sub>H31<\/sub>\u25cb4<\/sub>\uffe3)\u3002\u30b3\u30f3\u30d1\u30a6\u30f3\u30c9 73<\/b> \u524d\u99c6\u4f53\u30a4\u30aa\u30f3 [MH]\uffe3 \u304c\u751f\u6210\u3055\u308c\u307e\u3057\u305f\u3002 \u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 295.22803 \u3068\u7279\u5fb4\u7684\u306a\u65ad\u7247 \u30e1\u30fc\u30c8\u30eb<\/i>\/z<\/i>\u00a0277.21738 ([MHH2<\/sub>O]\u2212<\/sup> \u304a\u3088\u3073 195.13837 [M-(CHO-(CH2<\/sub>)4<\/sub>-CH3<\/sub>)-H]\uffe3\u3001\u70ad\u7d20\u539f\u5b50 13 \u756a\u76ee\u306e\u30d2\u30c9\u30ed\u30ad\u30b7\u30eb\u57fa\u306e\u4f4d\u7f6e\u3092\u793a\u3057\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u305d\u308c\u306f 13-\u30d2\u30c9\u30ed\u30ad\u30b7-9,11-\u30aa\u30af\u30bf\u30c7\u30ab\u30b8\u30a8\u30f3\u9178\u3067\u3042\u308b\u3068\u540c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001 S.\u30d5\u30eb\u30c6\u30a3\u30b3\u30b5<\/i> \u30c4\u30d9\u30ed\u30f3\u9178\u306e\u30b0\u30eb\u30b3\u30b7\u30c9\u306e\u5b58\u5728\u3092\u62bd\u51fa\u3057\u307e\u3059 (\u30e1\u30fc\u30c8\u30eb\/\u79d2<\/i> 387.16644) (\u8907\u5408 14<\/b>\uff09\u6210\u9577\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308b\u3053\u3068\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u4e3b\u8981\u306a\u690d\u7269\u5316\u5b66\u7269\u8cea\u306e\u5b9a\u91cf\u5206\u6790<\/h3>\n

\u3055\u307e\u3056\u307e\u306a\u62bd\u51fa\u7269\u4e2d\u306e\u4e3b\u306a\u30d5\u30a7\u30ce\u30fc\u30eb\u5316\u5408\u7269\u306e\u5b9a\u91cf\u5316 S.\u30d5\u30eb\u30c6\u30a3\u30b3\u30b5<\/i> \u690d\u7269\u6750\u6599\u306e\u4e7e\u71e5\u91cd\u91cf\uff08mg\/g DW\uff09\u3092\u8868\u306b\u793a\u3057\u307e\u3059\u3002 1<\/a>\u3002\u30b3\u30fc\u30d2\u30fc\u9178\u3001\u30b9\u30af\u30c6\u30e9\u30ea\u30f3\u3001\u30b5\u30eb\u30d3\u30a2\u30ce\u30fc\u30eb\u9178 B\u3001\u30ed\u30b9\u30de\u30ea\u30f3\u9178\u3001\u30ab\u30eb\u30ce\u30b7\u30f3\u9178\u3001\u304a\u3088\u3073\u30ab\u30eb\u30ce\u30bd\u30fc\u30eb\u306e\u542b\u6709\u91cf\u306f\u3001\u672c\u7269\u306e\u6a19\u6e96\u306e\u691c\u91cf\u7dda\u306b\u57fa\u3065\u3044\u3066\u8a08\u7b97\u3055\u308c\u3001\u4ed6\u306e\u5316\u5408\u7269\u306e\u542b\u6709\u91cf\u306f\u3001\u6700\u3082\u985e\u4f3c\u3057\u305f\u5165\u624b\u53ef\u80fd\u306a\u6a19\u6e96\u3068\u306e\u95a2\u4fc2\u3067\u63a8\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\n
\u8868 1 4 \u3064\u306e\u7570\u306a\u308b\u65b9\u6cd5\u3067\u6e2c\u5b9a\u3055\u308c\u305f\u4e3b\u8981\u306a\u30d5\u30a7\u30ce\u30fc\u30eb\u5316\u5408\u7269\u306e\u542b\u6709\u91cf (mg\/g DW) S.\u30d5\u30eb\u30c6\u30a3\u30b3\u30b5<\/i> \u62bd\u51fa\u7269\uff08SFH2<\/sub>O \u2013 \u6c34\u62bd\u51fa\u7269\u3002 SF30-30% \u30a8\u30bf\u30ce\u30fc\u30eb\u62bd\u51fa\u7269; SF70-70% \u30a8\u30bf\u30ce\u30fc\u30eb\u62bd\u51fa\u7269; SF100-\u30a8\u30bf\u30ce\u30fc\u30eb) HPLC-PDA \u306b\u3088\u308b\u3002<\/b><\/figcaption><\/figure>\n<\/div>\n

\u5168\u4f53\u3068\u3057\u3066\u3001\u30bb\u30fc\u30b8\u62bd\u51fa\u7269\u306b\u6700\u3082\u8c4a\u5bcc\u306b\u542b\u307e\u308c\u308b\u5316\u5408\u7269\u306f\u30ed\u30ba\u30de\u30ea\u30f3\u9178\u3067\u3001\u3053\u308c\u306f\u30d5\u30a7\u30ce\u30fc\u30eb\u9178\u3067\u3042\u308a\u3001\u30ab\u30d5\u30a7\u9178\u306e\u4e8c\u91cf\u4f53\u3067\u3059\u3002\u8a66\u9a13\u3057\u305f\u3059\u3079\u3066\u306e\u30b5\u30f3\u30d7\u30eb\u306e\u4e2d\u3067\u6700\u9ad8\u306e\u30ed\u30ba\u30de\u30ea\u30f3\u9178\u6fc3\u5ea6\u306f SF70 (31.56 \u00b1 1.88 mg\/g DW) \u3067\u898b\u3064\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001SF70 \u306e\u30ed\u30ba\u30de\u30ea\u30f3\u9178\u6fc3\u5ea6\u3068\u540c\u69d8\u3067\u3059\u3002 S.\u30d5\u30eb\u30c6\u30a3\u30b3\u30b5<\/i> \u30af\u30ed\u30a2\u30c1\u30a2\u304b\u3089\u63a1\u53d6\u3055\u308c\u305f\uff0829.10 \u00b1 0.21 mg\/g DW\uff09\u3001Mervi\u0107 et al. \u306b\u3088\u3063\u3066\u5831\u544a\u3055\u308c\u305f\u300223<\/a><\/sup>Sarrou \u3089\u304c\u7814\u7a76\u3057\u305f\u30ae\u30ea\u30b7\u30e3\u7523\u30bb\u30fc\u30b8\u306e\u30e1\u30bf\u30ce\u30fc\u30eb\u62bd\u51fa\u7269\u3067\u306f\u3001\u3055\u3089\u306b\u9ad8\u3044\u542b\u6709\u91cf (60.73 mg\/g DW) \u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u300219<\/a><\/sup>\u3057\u304b\u3057\u3001\u3053\u306e\u7814\u7a76\u3067\u306f\u6eb6\u5a92\u3068\u3057\u3066\u7d14\u7c8b\u306a\u30a2\u30eb\u30b3\u30fc\u30eb\u3092\u4f7f\u7528\u3057\u3066\u3082\u3001\u6700\u9ad8\u306e\u30ed\u30b9\u30de\u30ea\u30f3\u9178\u53ce\u7387\u306f\u5f97\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u8f38\u6db2\u4e2d\u306e\u30ed\u30ba\u30de\u30ea\u30f3\u9178\u6fc3\u5ea6\uff08SFH\uff092<\/sub>O)\u306f\u4ed6\u306e\u62bd\u51fa\u7269\u3088\u308a\u3082\u306f\u308b\u304b\u306b\u4f4e\u3044\uff084.96\u00b10.65mg\/g DW\uff09\u304c\u3001\u3053\u308c\u306f\u30c8\u30eb\u30b3\u7523\u306e\u54c1\u7a2e\u3067\u884c\u308f\u308c\u305f\u540c\u69d8\u306e\u6bd4\u8f03\u306e\u7d50\u679c\u3068\u4e00\u81f4\u3057\u306a\u3044\u3002 S.\u30d5\u30eb\u30c6\u30a3\u30b3\u30b5<\/i> \u30c6\u30ad\u30f3\u845718<\/a><\/sup>\u3002\u30b3\u30fc\u30d2\u30fc\u9178\u306f\u3001\u7814\u7a76\u3057\u305f\u3059\u3079\u3066\u306e\u62bd\u51fa\u7269\u304b\u3089\u3082\u540c\u69d8\u306e\u6fc3\u5ea6\uff080.13\uff5e0.15 mg\/g DW\uff09\u3067\u691c\u51fa\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u3053\u308c\u306f Mervi\u0107 \u3089\u306e\u5831\u544a\u3088\u308a\u3082 10 \u5206\u306e 1 \u4f4e\u304b\u3063\u305f\u3067\u3059\u300223<\/a><\/sup>\u3002\u3057\u304b\u3057\u3001\u30bb\u30fc\u30b8\u690d\u7269\u306e\u4e3b\u8981\u306a\u30ab\u30d5\u30a7\u9178\u7531\u6765\u4e09\u91cf\u4f53\u306b\u5c5e\u3059\u308b\u30b5\u30eb\u30d3\u30a2\u30ce\u30fc\u30eb\u9178\u306f\u3001\u3088\u308a\u591a\u91cf\u306b\u5b58\u5728\u3059\u308b\u3082\u306e\u306f\u307b\u3068\u3093\u3069\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u6700\u9ad8\u6fc3\u5ea6\u306e\u30b5\u30eb\u30d3\u30a2\u30ce\u30fc\u30eb\u9178 B \u306f\u3001SF70 \u304a\u3088\u3073 SF30 \u62bd\u51fa\u7269\u3067\u5f97\u3089\u308c\u307e\u3057\u305f (6.86 \u00b1 0.93 mg\/g DW \u304a\u3088\u3073 6.52 \u00b1 0.48 mg\/g DW)\u3002\u30b5\u30eb\u30d3\u30a2\u30ce\u30fc\u30eb\u9178 K \u306f ST30 \u62bd\u51fa\u7269\u4e2d\u306b\u6700\u3082\u8c4a\u5bcc\u3067\u3001\u6fc3\u5ea6\u306f 6.25 \u00b1 1.0 mg\/g DW \u3067\u3057\u305f\u3002 Cvetkovik\u3089\u306b\u3088\u3063\u3066\u63d0\u793a\u3055\u308c\u305f\u30c7\u30fc\u30bf\u306b\u3088\u308b\u3068\u300121<\/a><\/sup>\u3001\u7814\u7a76\u3055\u308c\u305f\u30ae\u30ea\u30b7\u30e3\u306e\u3044\u304f\u3064\u304b\u306e\u96c6\u56e3\u306b\u304a\u3051\u308b\u30b5\u30eb\u30d3\u30a2\u30ce\u30fc\u30eb\u9178K\u306e\u6700\u9ad8\u6fc3\u5ea6\u306f\u3001 S.\u30d5\u30eb\u30c6\u30a3\u30b3\u30b5<\/i> \uff17\uff0e\uff12\uff10\uff4d\uff47\uff0f\uff47\uff24\uff37\u3067\u3042\u3063\u305f\u3002<\/p>\n

\u6700\u3082\u8c4a\u5bcc\u306a\u30c6\u30eb\u30da\u30ce\u30a4\u30c9\u5316\u5408\u7269 S.\u30d5\u30eb\u30c6\u30a3\u30b3\u30b5<\/i> \u30ab\u30eb\u30ce\u30b7\u30f3\u9178\u3068\u30ab\u30eb\u30ce\u30bd\u30fc\u30eb\u306f\u3001\u3069\u3061\u3089\u3082\u30a2\u30d3\u30a8\u30bf\u30f3\u30b8\u30c6\u30eb\u30da\u30ce\u30a4\u30c9\u306e\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3057\u307e\u3059\u300212<\/a><\/sup>\u30ab\u30eb\u30ce\u30b7\u30f3\u9178\u306e\u542b\u6709\u91cf\u304c\u6700\u3082\u9ad8\u304b\u3063\u305f\u306e\u306f SF100 (14.82 \u00b1 1.66 mg\/g DW) \u3067\u3001\u6b21\u3044\u3067 SF70 (13.88 \u00b1 2.52 mg\/g DW) \u3067\u3001\u7d71\u8a08\u7684\u306b\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001Kallimanis \u3089\u306b\u3088\u308b\u30e1\u30bf\u30ce\u30fc\u30eb\u62bd\u51fa\u7269\u4e2d\u306e\u542b\u6709\u91cf\u306e\u6e2c\u5b9a\u7d50\u679c\u3068\u4e00\u81f4\u3057\u3066\u3044\u307e\u3059\u300224<\/a><\/sup> \u3053\u308c\u306f 12.5 \u00b1 1.6 mg\/g DW \u3067\u3057\u305f\u3002SF70 \u62bd\u51fa\u7269\u4e2d\u306e\u30ab\u30eb\u30ce\u30bd\u30fc\u30eb\u306e\u91cf\u306f 7.88 \u00b1 1.33 mg\/g DW \u3067\u3042\u308a\u3001Sarrou \u3089\u306b\u3088\u3063\u3066\u5831\u544a\u3055\u308c\u305f\u91cf\u3068\u4e00\u81f4\u3057\u307e\u3057\u305f\u300219<\/a><\/sup>\u7814\u7a76\u3055\u308c\u305f\u62bd\u51fa\u7269\u306e\u4e2d\u30673\u756a\u76ee\u306b\u8c4a\u5bcc\u306a\u30c6\u30eb\u30da\u30ce\u30a4\u30c9\u3067\u3042\u308b\u30b5\u30eb\u30d3\u30aa\u30fc\u30eb\u306f\u3001\u30a2\u30d3\u30a8\u30bf\u30f3\u30b8\u30c6\u30eb\u30da\u30ce\u30a4\u30c9\u3067\u3042\u308b\u30d5\u30a7\u30eb\u30ae\u30ce\u30fc\u30eb\u304b\u3089\u8a98\u5c0e\u3055\u308c\u305f\u30e1\u30ed\u30c6\u30eb\u30da\u30ce\u30a4\u30c9\u3067\u3042\u308a\u3001\u4f8b\u3048\u3070\u4ed6\u306e\u30ae\u30ea\u30b7\u30e3\u306e\u30bb\u30fc\u30b8\u7a2e\u306b\u3088\u304f\u898b\u3089\u308c\u307e\u3059\u3002 S.\u30dd\u30df\u30d5\u30a7\u30e9<\/i>25<\/a><\/sup>\u3053\u306e\u5316\u5408\u7269\u306f\u3001 S.\u30d5\u30eb\u30c6\u30a3\u30b3\u30b5<\/i>;\u3057\u304b\u3057\u3001\u305d\u308c\u306f\u7814\u7a76\u3055\u308c\u305f\u62bd\u51fa\u7269\u306e\u307b\u3068\u3093\u3069\u306b\u5b58\u5728\u3057\u3001\u6700\u9ad8\u542b\u91cf\uff1aSF70 \u3067 7.37 \u00b1 0.71 mg\/g DW \u3067\u3057\u305f\u3002<\/p>\n

\u3067\u691c\u51fa\u3055\u308c\u305f\u751f\u7269\u6d3b\u6027\u7269\u8cea\u306e 3 \u756a\u76ee\u306e\u30b0\u30eb\u30fc\u30d7 S.\u30d5\u30eb\u30c6\u30a3\u30b3\u30b5<\/i> \u62bd\u51fa\u7269\u306f\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u3067\u3057\u305f\u3002\u30b9\u30af\u30c6\u30e9\u30ea\u30f3\u306f\u30bb\u30fc\u30b8\u306b\u542b\u307e\u308c\u308b\u4e00\u822c\u7684\u306a\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306e 1 \u3064\u3067\u305926<\/a><\/sup>\u7814\u7a76\u5bfe\u8c61\u62bd\u51fa\u7269\u4e2d\u3067\u6700\u3082\u8c4a\u5bcc\u306a\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u3067\u3042\u308a\u3001SFH\u3067\u306f7.77 \u00b1 0.48 mg\/g DW\u30018.92 \u00b1 1.56 mg\/g DW\u30017.35 \u00b1 0.9 mg\/g DW\u3068\u3001\u540c\u69d8\u306e\u53ce\u91cf\u3067\u3042\u3063\u305f\u30022<\/sub>\u305d\u308c\u305e\u308cO\u3001SF30\u3001SF70\u62bd\u51fa\u7269\u3002\u30eb\u30c6\u30aa\u30ea\u30f3 \u30eb\u30c1\u30ce\u30b7\u30c9\u3068\u30eb\u30c6\u30aa\u30ea\u30f3\u30b0\u30eb\u30b3\u30b7\u30c9\u306e\u6fc3\u5ea6\u306f\u3001\u7814\u7a76\u3057\u305f\u3059\u3079\u3066\u306e\u62bd\u51fa\u7269\u3067\u540c\u69d8\u3067\u30011.03 \uff5e 1.98 mg\/g DW \u306e\u7bc4\u56f2\u3067\u3057\u305f\u304c\u3001\u3053\u308c\u306f Tekin \u3089\u306b\u3088\u3063\u3066\u5831\u544a\u3055\u308c\u305f\u30c7\u30fc\u30bf\u3068\u306f\u4e00\u81f4\u3057\u307e\u305b\u3093\u300218<\/a><\/sup>\u3053\u3053\u3067\u3001\u30bb\u30fc\u30b8\u6ce8\u5165\u4e2d\u306e\u3053\u308c\u3089\u306e\u5316\u5408\u7269\u306e\u6fc3\u5ea6\u306f\u3001\u30a8\u30bf\u30ce\u30fc\u30eb\u62bd\u51fa\u7269\u4e2d\u306e\u6fc3\u5ea6\u3088\u308a\u3082 2 \uff5e 3 \u500d\u9ad8\u304b\u3063\u305f\u3002<\/p>\n

\u30d5\u30a7\u30ce\u30fc\u30eb\u9178\u3001\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u3001\u30c6\u30eb\u30da\u30ce\u30a4\u30c9\u306f\u3001\u4ee3\u8868\u7684\u306a\u751f\u7406\u6d3b\u6027\u5316\u5408\u7269\u3067\u3059\u3002 S.\u30d5\u30eb\u30c6\u30a3\u30b3\u30b5<\/i>\u8868\u306b\u793a\u3059\u3088\u3046\u306b 1<\/a>\u3001\u62bd\u51fa\u53ce\u7387\u306f\u6eb6\u5a92\u4e2d\u306e\u30a8\u30bf\u30ce\u30fc\u30eb\u542b\u6709\u91cf\u306b\u5927\u304d\u304f\u5f71\u97ff\u3055\u308c\u307e\u3057\u305f\u3002\u6c34\u306e\u307f\u306b\u3088\u308b\u62bd\u51fa\u3068\u306f\u5bfe\u7167\u7684\u306b\u300170% \u30a8\u30bf\u30ce\u30fc\u30eb\u306b\u3088\u308b\u62bd\u51fa\u3067\u306f\u3001\u751f\u7269\u6d3b\u6027\u7269\u8cea\u306e\u7dcf\u53ce\u91cf\u304c\u6700\u3082\u9ad8\u304f\u306a\u308a\u307e\u3057\u305f\u3002\u9055\u3044\u306f\u30d5\u30a7\u30ce\u30fc\u30eb\u9178\u3068\u30c6\u30eb\u30da\u30ce\u30a4\u30c9\u306e\u53ce\u7387\u306b\u306f\u3063\u304d\u308a\u3068\u73fe\u308c\u3066\u304a\u308a\u3001SF70 \u3067\u306f\u305d\u308c\u305e\u308c 3 \u500d\u30017 \u500d\u9ad8\u304b\u3063\u305f\u3002\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306e\u6700\u5927\u62bd\u51fa\u53ce\u91cf\u306f 30% \u30a8\u30bf\u30ce\u30fc\u30eb\u3067\u5f97\u3089\u308c\u307e\u3057\u305f\u304c\u300170% \u30a8\u30bf\u30ce\u30fc\u30eb\u3067\u5f97\u3089\u308c\u305f\u53ce\u91cf\u3088\u308a\u3082\u308f\u305a\u304b\u306b\u9ad8\u3044\u3060\u3051\u3067\u3057\u305f\u3002\u7814\u7a76\u3055\u308c\u305f\u751f\u7269\u6d3b\u6027\u7269\u8cea\u306e\u3059\u3079\u3066\u306e\u30b0\u30eb\u30fc\u30d7\u3092\u8003\u616e\u3059\u308b\u3068\u300170% \u30a8\u30bf\u30ce\u30fc\u30eb\u304c\u3001\u751f\u7269\u6d3b\u6027\u5316\u5408\u7269\u306e\u62bd\u51fa\u306b\u3064\u3044\u3066\u8a66\u9a13\u3055\u308c\u305f\u6eb6\u5a92\u306e\u4e2d\u3067\u6700\u826f\u306e\u6eb6\u5a92\u3067\u3042\u308b\u3068\u7d50\u8ad6\u4ed8\u3051\u3089\u308c\u307e\u3059\u3002 S.\u30d5\u30eb\u30c6\u30a3\u30b3\u30b5<\/i>.<\/p>\n

\u6297\u9178\u5316\u4f5c\u7528<\/h3>\n

\u690d\u7269\u6750\u6599\u4e2d\u306b\u6297\u9178\u5316\u6d3b\u6027\u3092\u793a\u3059\u5316\u5408\u7269\u306e\u5b58\u5728\u306f\u3001\u305d\u306e\u5065\u5eb7\u5897\u9032\u7279\u6027\u3092\u5b9a\u7fa9\u3059\u308b\u91cd\u8981\u306a\u5074\u9762\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3055\u307e\u3056\u307e\u306a\u7a2e\u985e\u306e\u30bb\u30fc\u30b8\u306e\u5834\u5408\u3001\u305d\u306e\u9ad8\u3044\u6297\u9178\u5316\u6d3b\u6027\u306f\u4e3b\u306b\u30d5\u30a7\u30ce\u30fc\u30eb\u5316\u5408\u7269\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002\u63d0\u793a\u3055\u308c\u305f\u7814\u7a76\u3067\u306f\u3001\u7dcf\u6297\u9178\u5316\u6d3b\u6027\u306f\u6b21\u306e\u3088\u3046\u306b\u6c7a\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002 S.\u30d5\u30eb\u30c6\u30a3\u30b3\u30b5<\/i> \u7570\u306a\u308b\u6975\u6027\u306e\u62bd\u51fa\u5264\u3067\u8abf\u88fd\u3057\u305f\u62bd\u51fa\u7269\u3002\u3055\u3089\u306b\u3001\u30bb\u30fc\u30b8\u306b\u5178\u578b\u7684\u3067\u3001\u30d5\u30a7\u30ce\u30fc\u30eb\u9178\u3001\u30d5\u30e9\u30dc\u30f3\u3001\u30b8\u30c6\u30eb\u30da\u30ce\u30a4\u30c9\u306a\u3069\u306e\u3055\u307e\u3056\u307e\u306a\u30af\u30e9\u30b9\u306e\u4e8c\u6b21\u4ee3\u8b1d\u7523\u7269\u306b\u5c5e\u3059\u308b\u7279\u5b9a\u306e\u30d5\u30a7\u30ce\u30fc\u30eb\u5316\u5408\u7269\u306e\u6297\u9178\u5316\u6d3b\u6027\u3092\u6e2c\u5b9a\u3057\u307e\u3057\u305f\u3002<\/p>\n

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\n
\u56f32<\/b><\/figcaption>
\n
\"figure<\/picture><\/a><\/div>\n
\n

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\u6c34\u6027\u62bd\u51fa\u7269 (SFH)2<\/sub>O) \u6297\u9178\u5316\u6d3b\u6027\u306f\u4e3b\u306b 2 \u3064\u306e\u5316\u5408\u7269\u3001\u3059\u306a\u308f\u3061\u30d7\u30ec\u30ef\u30eb\u30b9\u30ad\u30cb\u30f3\u9178 A \u3068\u30b9\u30af\u30c6\u30e9\u30ea\u30f3\u306b\u7531\u6765\u3057\u3066\u304a\u308a\u3001\u6c34\u306e\u307f\u306b\u3088\u308b\u30ed\u30b9\u30de\u30ea\u30f3\u9178\u306e\u62bd\u51fa\u3067\u306f\u52b9\u679c\u304c\u4f4e\u304b\u3063\u305f\u3002<\/p>\n

\u30ad\u30b5\u30f3\u30c1\u30f3\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc\u963b\u5bb3\u6d3b\u6027<\/h3>\n

\u30ad\u30b5\u30f3\u30c1\u30f3\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc (XO) \u9175\u7d20\u306f\u3001\u30d2\u30dd\u30ad\u30b5\u30f3\u30c1\u30f3\u3068\u30ad\u30b5\u30f3\u30c1\u30f3\u3092\u5c3f\u9178\u306b\u9178\u5316\u3059\u308b\u89e6\u5a92\u4f5c\u7528\u3092\u3057\u307e\u3059\u3002\u5c3f\u9178\u304c\u8840\u6db2\u4e2d\u306b\u904e\u5270\u306b\u306a\u308b\u3068\u75db\u98a8\u3092\u767a\u75c7\u3057\u307e\u3059\u3002XO \u306e\u518d\u9178\u5316\u4e2d\u3001\u5206\u5b50\u9178\u7d20\u306f\u96fb\u5b50\u53d7\u5bb9\u4f53\u3068\u3057\u3066\u50cd\u304d\u3001\u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b7\u30c9\u30e9\u30b8\u30ab\u30eb\u3068\u904e\u9178\u5316\u6c34\u7d20\u3092\u751f\u6210\u3057\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001XO \u306f\u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b7\u30c9\u30e9\u30b8\u30ab\u30eb\u306e\u91cd\u8981\u306a\u751f\u7269\u5b66\u7684\u767a\u751f\u6e90\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304a\u308a\u3001\u4ed6\u306e\u6d3b\u6027\u9178\u7d20\u7a2e\u3068\u3068\u3082\u306b\u4f53\u5185\u306e\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u5bc4\u4e0e\u3057\u3001\u708e\u75c7\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u3001\u764c\u3001\u8001\u5316\u306a\u3069\u591a\u304f\u306e\u75c5\u7406\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u300232<\/a><\/sup>\u6700\u8fd1\u306e\u9ad8\u5c3f\u9178\u8840\u75c7\u6cbb\u7642\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001XO\u9175\u7d20\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u3059\u3002XO\u963b\u5bb3\u5264\uff08\u30a2\u30ed\u30d7\u30ea\u30ce\u30fc\u30eb\u3001\u30d5\u30a7\u30d6\u30ad\u30bd\u30b9\u30bf\u30c3\u30c8\uff09\u3092\u542b\u3080\u3055\u307e\u3056\u307e\u306a\u85ac\u5264\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u6b8b\u5ff5\u306a\u304c\u3089\u305d\u306e\u4f7f\u7528\u306b\u306f\u7279\u5b9a\u306e\u526f\u4f5c\u7528\u304c\u4f34\u3044\u307e\u3059\u3002\u3053\u306e\u305f\u3081\u3001\u3053\u308c\u3089\u306e\u5408\u6210\u5316\u5408\u7269\u306e\u4ee3\u66ff\u3068\u306a\u308b\u5929\u7136\u306eXO\u963b\u5bb3\u5264\u304c\u7d76\u3048\u305a\u63a2\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6587\u732e\u306b\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u7a2e\u306eXO\u963b\u5bb3\u5264\u306e\u80fd\u529b\u306b\u95a2\u3059\u308b\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u3002 \u30b5\u30eb\u30d3\u30a2<\/i> (S. plebeia\u3001S. miltiorrhiza\u3001S. verbenaca<\/i>\uff09XO\u3092\u963b\u5bb3\u3059\u308b33<\/a>,34<\/a>,35<\/a><\/sup>\u3057\u305f\u304c\u3063\u3066\u3001\u3053\u306e\u6d3b\u52d5\u306e\u767a\u751f\u306e\u53ef\u80fd\u6027\u3082\u7814\u7a76\u5bfe\u8c61\u3067\u30c6\u30b9\u30c8\u3055\u308c\u307e\u3057\u305f\u3002 S.\u30d5\u30eb\u30c6\u30a3\u30b3\u30b5<\/i> \u629c\u7c8b\u3057\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u30ab\u30d5\u30a7\u9178\u3001\u30ab\u30eb\u30ce\u30b7\u30f3\u9178\u3001\u30ab\u30eb\u30ce\u30bd\u30fc\u30eb\u3001\u30b5\u30eb\u30d3\u30a2\u30ce\u30fc\u30eb\u9178 B\u3001\u30b9\u30af\u30c6\u30e9\u30ea\u30f3\u3001\u30ed\u30ba\u30de\u30ea\u30f3\u9178\u3001\u3055\u3089\u306b\u53c2\u8003\u307e\u3067\u306b\u3001XO \u963b\u5bb3\u5264\u30a2\u30ed\u30d7\u30ea\u30ce\u30fc\u30eb\u306a\u3069\u3001\u30bb\u30fc\u30b8\u306b\u5178\u578b\u7684\u306a\u9078\u629e\u3055\u308c\u305f\u30d5\u30a7\u30ce\u30fc\u30eb\u5316\u5408\u7269\u3067\u3082 XO \u963b\u5bb3\u6d3b\u6027\u304c\u6e2c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u8a66\u9a13\u30b5\u30f3\u30d7\u30eb\u306e\u5b58\u5728\u306e\u6709\u7121\u306b\u304b\u304b\u308f\u3089\u305a\u3001XO \u306b\u3088\u308b\u30ad\u30b5\u30f3\u30c1\u30f3 (\u57fa\u8cea) \u304b\u3089\u5c3f\u9178 (\u751f\u6210\u7269) \u3078\u306e\u5909\u63db\u3092\u3001285 nm \u3067 HPLC-PAD \u3092\u4f7f\u7528\u3057\u3066\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3057\u307e\u3057\u305f (\u56f3 1)\u3002\u00a03<\/a>a\uff09\u3002\u9175\u7d20\u6d3b\u6027\u306f\u3001\u30b5\u30f3\u30d7\u30eb\u3092\u6dfb\u52a0\u3057\u306a\u3044\u5bfe\u7167\u3068\u6bd4\u8f03\u3057\u305f\u3001\u8a66\u9a13\u30b5\u30f3\u30d7\u30eb\u306e\u5b58\u5728\u4e0b\u3067\u5f62\u6210\u3055\u308c\u305f\u5c3f\u9178\u30d4\u30fc\u30af\u9762\u7a4d\u306e\u30d1\u30fc\u30bb\u30f3\u30c6\u30fc\u30b8\u3068\u3057\u3066\u8a08\u7b97\u3055\u308c\u307e\u3057\u305f\uff08\u56f31\uff09\u3002\u00a03<\/a>b) XO\u9175\u7d20\u306e\u963b\u5bb3\u306fIC50<\/sub> \u5024\u306f\u3001\u9175\u7d20\u6d3b\u6027\u3092 50% \u307e\u3067\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u30b5\u30f3\u30d7\u30eb\u306e\u6a19\u6e96\u91cd\u91cf\u307e\u305f\u306f\u4e7e\u71e5\u91cd\u91cf (\u03bcg) \u306e\u8cea\u91cf\u3092\u610f\u5473\u3057\u307e\u3059 (\u56f3\u00a03<\/a>\u7d00\u5143\u524d\uff09\u3002<\/p>\n

\n
\u56f33<\/b><\/figcaption>
\n
\"figure<\/picture><\/a><\/div>\n
\n

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\u65e2\u77e5\u306e XO \u963b\u5bb3\u5264\u30a2\u30ed\u30d7\u30ea\u30ce\u30fc\u30eb\u3092\u57fa\u6e96\u3068\u3057\u3066\u4f7f\u7528\u3057\u3001IC \u3092\u4f7f\u7528\u3057\u307e\u3057\u305f\u300250<\/sub> 0.15\u03bcg\uff085.5\u03bcM\uff09\u306e\u5024\u3067\u3042\u3063\u305f\u3002\u8a66\u9a13\u3057\u305f\u3059\u3079\u3066\u306e\u6a19\u6e96\u7269\u8cea\u306f\u3001IC50<\/sub> 0.1 \uff5e 3.15 \u03bcg (2.8 \uff5e 43.8 \u03bcM) \u306e\u7bc4\u56f2\u3067\u3059\u3002 XO\u963b\u5bb3\u6d3b\u6027\u306f\u3001\u30ed\u30b9\u30de\u30ea\u30f3\u9178 < \u30ab\u30eb\u30ce\u30b7\u30f3\u9178 < \u30b9\u30af\u30c6\u30e9\u30ea\u30f3 < \u30b5\u30eb\u30d3\u30a2\u30ce\u30fc\u30eb\u9178 B < \u30ab\u30eb\u30ce\u30bd\u30fc\u30eb < \u30ab\u30d5\u30a7\u9178\u306e\u9806\u306b\u5897\u52a0\u3057\u307e\u3057\u305f\u3002\u30b3\u30fc\u30d2\u30fc\u9178\u306f\u6700\u3082\u4f4e\u3044IC\u3092\u793a\u3057\u307e\u3057\u305f50<\/sub> \u5024 (0.1 \u03bcg; 2.8 \u03bcM) \u306f\u3001\u8a66\u9a13\u3057\u305f\u5316\u5408\u7269\u306e\u4e2d\u3067\u6700\u3082\u5f37\u3044 XO \u963b\u5bb3\u6d3b\u6027\u3092\u793a\u3057\u307e\u3059\u3002\u305d\u308c\u306f\u30a2\u30ed\u30d7\u30ea\u30ce\u30fc\u30eb\u3088\u308a\u3082\u3055\u3089\u306b\u5f37\u529b\u3067\u3057\u305f\u304c\u3001\u3053\u308c\u306fWan\u3089\u306b\u3088\u3063\u3066\u63d0\u793a\u3055\u308c\u305f\u30c7\u30fc\u30bf\u3068\u4e00\u81f4\u3057\u307e\u305b\u3093\u300236<\/a><\/sup> \u304a\u3088\u3073Flemmig\u3089\u300237<\/a><\/sup>\u3001IC50<\/sub> \u30ab\u30d5\u30a7\u9178\u306e\u6fc3\u5ea6\u306f\u3001\u305d\u308c\u305e\u308c\u30a2\u30ed\u30d7\u30ea\u30ce\u30fc\u30eb\u306e\u307b\u307c 8 \u5206\u306e 1 \u307e\u305f\u306f 2 \u5206\u306e 1 \u3067\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u9055\u3044\u306f\u3001\u30c6\u30b9\u30c8\u7528\u306b\u9078\u629e\u3055\u308c\u305f XO \u306e\u8d77\u6e90\u306b\u8d77\u56e0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u5f15\u7528\u3055\u308c\u305f\u7814\u7a76\u3067\u306f\u725b\u4e73\u7531\u6765\u306e\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc\u304c\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u3053\u306e\u7814\u7a76\u3067\u306f\u5fae\u751f\u7269\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc\u304c\u9078\u629e\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u30ed\u30ba\u30de\u30ea\u30f3\u9178\u306e XO \u963b\u5bb3\u529b\u304c\u6700\u3082\u4f4e\u304b\u3063\u305f (3.2 \u03bcg; 43.8 \u03bcM) \u304c\u3001Ghallab et al.38<\/a><\/sup> \u30a2\u30ed\u30d7\u30ea\u30ce\u30fc\u30eb\u3068\u30ed\u30b9\u30de\u30ea\u30f3\u9178\u306e\u76f8\u4e57\u7684\u306a\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u308a\u3001\u5fc5\u8981\u306a\u5408\u6210\u85ac\u7269\u306e\u6295\u4e0e\u91cf\u3092\u6e1b\u3089\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u5831\u544a\u3057\u307e\u3057\u305f\u3002 XO\u306f\u7814\u7a76\u3055\u308c\u305f\u3059\u3079\u3066\u306e\u7269\u8cea\u3067\u963b\u5bb3\u3055\u308c\u305f S.\u30d5\u30eb\u30c6\u30a3\u30b3\u30b5<\/i> \u62bd\u51fa\u7269\u306f\u3001\u30a2\u30ed\u30d7\u30ea\u30ce\u30fc\u30eb\u3088\u308a\u30821000\u500d\u4ee5\u4e0a\u52b9\u679c\u304c\u4f4e\u3044\u304c\u3001\u4ed6\u306e\u7814\u7a76\u3067\u5831\u544a\u3055\u308c\u305f\u30c7\u30fc\u30bf\u3068\u4e00\u81f4\u3057\u3066\u3044\u308b\u3002 \u30b5\u30eb\u30d3\u30a2<\/i> \u30b9\u30af\u30c6\u30e9\u30ea\u30f3\u3068\u4ed6\u306e\u30d5\u30e9\u30dc\u30f3\u306f\u3001XO\u306e\u5f37\u529b\u306a\u963b\u5bb3\u5264\u3068\u3057\u3066\u4ee5\u524d\u306b\u8aac\u660e\u3055\u308c\u3066\u3044\u308b\u300239<\/a><\/sup>\u3002 SF30 \u62bd\u51fa\u7269\u3068 SF70 \u62bd\u51fa\u7269\u306e\u7dcf\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u542b\u6709\u91cf\u306b\u306f\u308f\u305a\u304b\u306a\u9055\u3044\u304c\u3042\u308a\u3001\u4ed6\u306e\u6297\u708e\u75c7\u5316\u5408\u7269\u306e\u542b\u6709\u91cf\u306f SF70 \u62bd\u51fa\u7269\u306e\u65b9\u304c\u6709\u5229\u3067\u3042\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001SF30 \u306f XO \u6d3b\u6027\u3092\u963b\u5bb3\u3059\u308b\u6700\u3082\u5f37\u529b\u306a\u80fd\u529b\u3092\u6301\u3063\u3066\u3044\u307e\u3057\u305f\u3002 IC50<\/sub> SF30 \u306e\u5024\u306f 50 \u03bcg \u3067\u3042\u308a\u3001\u3053\u306e\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u306b\u57fa\u3065\u3044\u3066\u3001SF70\u3001SF100\u3001\u304a\u3088\u3073 SFH \u306e\u6f5c\u5728\u7684\u306a\u6297\u708e\u75c7\u6d3b\u6027\u304c\u6c7a\u307e\u308a\u307e\u3057\u305f\u30022<\/sub>O \u62bd\u51fa\u7269\u306f\u305d\u308c\u305e\u308c 3\u30014\u30015 \u500d\u5f31\u3044\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n

[ad_2]<\/p>\n

\u30bd\u30fc\u30b9\u30ea\u30f3\u30af <\/a><\/p>","protected":false},"excerpt":{"rendered":"

This study explores the influence of extraction solvents on the composition and bioactivity of Salvia fruticosa extracts. Ultrasound-assisted extraction with water, ethanol and their mixtures in variable proportions was used to produce four different extracts.<\/p>","protected":false},"author":1,"featured_media":5372,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9],"tags":[],"class_list":["post-4869","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-supplements"],"_links":{"self":[{"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/posts\/4869","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/comments?post=4869"}],"version-history":[{"count":2,"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/posts\/4869\/revisions"}],"predecessor-version":[{"id":8265,"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/posts\/4869\/revisions\/8265"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/media\/5372"}],"wp:attachment":[{"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/media?parent=4869"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/categories?post=4869"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/tags?post=4869"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}