{"id":5081,"date":"2024-01-15T12:21:35","date_gmt":"2024-01-15T12:21:35","guid":{"rendered":"https:\/\/www.farlong.com\/?p=5081"},"modified":"2024-01-27T10:42:32","modified_gmt":"2024-01-27T10:42:32","slug":"therapeutic-effects-of-breviscapine-in-cardiovascular-diseases-a-review","status":"publish","type":"post","link":"https:\/\/directcm.com\/ja\/therapeutic-effects-of-breviscapine-in-cardiovascular-diseases-a-review\/","title":{"rendered":"\u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u304a\u3051\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u6cbb\u7642\u52b9\u679c\uff1a\u7dcf\u8aac"},"content":{"rendered":"<div id=\"abstract-a.k.b.n\" class=\"tsec sec\" lang=\"en\">\n<div id=\"abstract-a.k.b.n\" class=\"tsec sec\" lang=\"en\">\n<div>\n<div class=\"fm-sec half_rhythm no_top_margin\">\n<div class=\"half_rhythm\"><\/div>\n<\/div>\n<div class=\"sec\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" style=\"font-size: 16px; background-color: #ffffff;\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"menuitem\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<div id=\"abstract-a.k.b.n\" class=\"tsec sec\" lang=\"en\">\n<h2 id=\"abstract-a.k.b.ntitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u62bd\u8c61\u7684\u306a<\/h2>\n<div>\n<p class=\"p p-first-last\"><span style=\"font-size: 16px;\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306e\u7c97\u62bd\u51fa\u7269\u3067\u3059\u3002 <\/span><em style=\"font-size: 16px;\">Erigeron breviscapus (Vant.) Hand.-Mazz.<\/em><span style=\"font-size: 16px;\">\u3001\u8133\u306e\u8840\u6db2\u4f9b\u7d66\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u8840\u6db2\u5faa\u74b0\u3092\u6d3b\u6027\u5316\u3059\u308b\u85ac\u3068\u3057\u3066\u4e2d\u56fd\u3067\u4f1d\u7d71\u7684\u306b\u4f7f\u7528\u3055\u308c\u3066\u304d\u305f\u30b9\u30af\u30c6\u30e9\u30ea\u30f3\u309285%\u4ee5\u4e0a\u542b\u3093\u3067\u3044\u307e\u3059\u3002\u3055\u307e\u3056\u307e\u306a\u8a3c\u62e0\u3092\u84c4\u7a4d\u3057\u3066\u3044\u304f\u00a0<\/span><em style=\"font-size: 16px;\">\u751f\u4f53\u5185<\/em><span style=\"font-size: 16px;\">\u00a0\u305d\u3057\u3066\u00a0<\/span><em style=\"font-size: 16px;\">\u8a66\u9a13\u7ba1\u5185\u3067<\/em><span style=\"font-size: 16px;\">\u00a0\u7814\u7a76\u3067\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u8840\u7ba1\u62e1\u5f35\u3001\u865a\u8840\/\u518d\u704c\u6d41\uff08I\/R\uff09\u306b\u5bfe\u3059\u308b\u4fdd\u8b77\u3001\u6297\u708e\u75c7\u3001\u6297\u51dd\u56fa\u3001\u6297\u8840\u6813\u3001\u5185\u76ae\u4fdd\u8b77\u3001\u5fc3\u7b4b\u4fdd\u8b77\u3001\u5e73\u6ed1\u7b4b\u7d30\u80de\u306e\u904a\u8d70\u3068\u5897\u6b96\u306e\u6e1b\u5c11\u306a\u3069\u3001\u5e83\u7bc4\u56f2\u306e\u5fc3\u8840\u7ba1\u85ac\u7406\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u3001\u6297\u5fc3\u81d3\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3001\u6297\u4e0d\u6574\u8108\u3001\u8840\u4e2d\u8102\u8cea\u306e\u6e1b\u5c11\u3001\u52c3\u8d77\u4e0d\u5168\u306e\u6539\u5584\u3002\u3055\u3089\u306b\u3001\u3044\u304f\u3064\u304b\u306e\u81e8\u5e8a\u7814\u7a76\u3067\u306f\u3001\u51a0\u72b6\u52d5\u8108\u6027\u5fc3\u75be\u60a3\u3001\u5fc3\u7b4b\u6897\u585e\u3001\u9ad8\u8840\u5727\u3001\u5fc3\u623f\u7d30\u52d5\u3001\u9ad8\u8102\u8840\u75c7\u3001\u30a6\u30a4\u30eb\u30b9\u6027\u5fc3\u7b4b\u708e\u3001\u6162\u6027\u5fc3\u4e0d\u5168\u3001\u80ba\u5fc3\u75be\u60a3\u306a\u3069\u306e\u5fc3\u8840\u7ba1\u75be\u60a3\uff08CVD\uff09\u306b\u5bfe\u3057\u3066\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u897f\u6d0b\u533b\u5b66\u3068\u4f75\u7528\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u3002\u3057\u304b\u3057\u3001\u5b9f\u9a13\u7814\u7a76\u306b\u57fa\u3065\u304f CVD \u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u4fdd\u8b77\u52b9\u679c\u3068\u305d\u306e\u57fa\u790e\u3068\u306a\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u4f53\u7cfb\u7684\u306b\u691c\u8a0e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u3053\u306e\u8ad6\u6587\u3067\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u5fc3\u81d3\u4fdd\u8b77\u52b9\u679c\u306e\u6839\u5e95\u306b\u3042\u308b\u85ac\u7406\u5b66\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u30ec\u30d3\u30e5\u30fc\u3057\u3001\u305d\u306e\u81e8\u5e8a\u5fdc\u7528\u3092\u89e3\u660e\u3057\u307e\u3057\u305f\u3002<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"sec\"><strong class=\"kwd-title\">\u30ad\u30fc\u30ef\u30fc\u30c9:\u00a0<\/strong><span class=\"kwd-text\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u3001\u4e2d\u56fd\u533b\u5b66\u3001\u6c11\u65cf\u85ac\u7406\u5b66\u3001\u6f22\u65b9\u85ac\u3001\u30cf\u30fc\u30d6\u6d3b\u6027\u5316\u5408\u7269<\/span><\/div>\n<div><\/div>\n<\/div>\n<div id=\"sec-a.l.a\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"sec-a.l.atitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u5c0e\u5165<\/h2>\n<p>&nbsp;<\/p>\n<p class=\"p p-first\"><em>\u30a8\u30ea\u30b2\u30ed\u30f3\u30fb\u30d6\u30ec\u30d3\u30b9\u30ab\u30d7\u30b9<\/em>\u00a0(<em>Erigeron breviscapus (Vant.) Hand.-Mazz.<\/em>\uff09\u3001 \u3068\u3057\u3066\u3082\u77e5\u3089\u308c\u3066\u3044\u308b\u00a0<em>\u30cf\u30fc\u30d0\u30fb\u30a8\u30ea\u30b2\u30ed\u30f3\u30c6\u30a3\u30b9<\/em>\u00a0\u307e\u305f\u306f\u00a0<em>\u30e9\u30f3\u30d7\u83ca<\/em>\u3001\u96f2\u5357\u7701\u3001\u56db\u5ddd\u7701\u3001\u8cb4\u5dde\u7701\u3001\u305d\u306e\u4ed6\u306e\u4e2d\u56fd\u5357\u897f\u90e8\u306e\u7701\u3067\u767a\u898b\u3055\u308c\u3001600\u5e74\u4ee5\u4e0a\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u4f1d\u7d71\u7684\u306a\u4e2d\u56fd\u306e\u30cf\u30fc\u30d6\u3067\u3059\u3002\u3053\u308c\u306f\u30c7\u30a4\u30b8\u30fc\u79d1\u306b\u5c5e\u3057\u3001\u584a\u3092\u5f62\u6210\u3059\u308b\u591a\u5e74\u751f\u306e\u8349\u672c\u3067\u3001\u9ad8\u3055\u306f\u6700\u5927 50 cm (20 \u30a4\u30f3\u30c1) \u307e\u3067\u6210\u9577\u3057\u307e\u3059\u304c\u3001\u5834\u5408\u306b\u3088\u3063\u3066\u306f\u9ad8\u3055\u304c 1 cm (0.4 \u30a4\u30f3\u30c1) \u672a\u6e80\u306b\u306a\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u305d\u306e\u982d\u82b1\u306b\u306f\u3001\u9ec4\u8272\u306e\u5186\u76e4\u72b6\u5c0f\u82b1\u3092\u56f2\u3080\u9752\u3001\u7d2b\u3001\u307e\u305f\u306f\u767d\u306e\u820c\u72b6\u82b1\u304c\u3042\u308a\u307e\u3059\uff08\u56f3\u306b\u793a\u3059\u3088\u3046\u306b\uff09\u3002\u00a0<strong>\u5f62\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/figure\/F1\/\" target=\"figure\" rel=\"noopener\">\u200b<span class=\"figpopup-sensitive-area\">\u56f31<\/span>1<\/a><\/strong>\uff09\u3002\u5168\u8349\u3092\u4e7e\u71e5\u3055\u305b\u305f\u3082\u306e\u00a0<em>\u30a8\u30ea\u30b2\u30ed\u30f3\u30fb\u30d6\u30ec\u30d3\u30b9\u30ab\u30d7\u30b9<\/em>\u00a0\u6c11\u9593\u7642\u6cd5\u3067\u306f\u9ebb\u75fa\u3001\u30ea\u30a6\u30de\u30c1\u3001\u80c3\u708e\u3001\u6b6f\u75db\u3001\u767a\u71b1\u306e\u6cbb\u7642\u306b\u4f7f\u7528\u3055\u308c\u3066\u304d\u307e\u3057\u305f\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B92\" aria-expanded=\"false\" aria-haspopup=\"true\">\u96f2\u5357\u7701\u30de\u30c6\u30ea\u30a2\u30e1\u30c7\u30a3\u30ab\u7814\u7a76\u6240\u30011976 \u5e74<\/a>).<\/p>\n<div id=\"F1\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm140218700826464\"><img decoding=\"async\" class=\"fig-image\" title=\"\u5199\u771f\u3001\u30a4\u30e9\u30b9\u30c8\u306a\u3069\u3092\u4fdd\u6301\u3059\u308b\u5916\u90e8\u30d5\u30a1\u30a4\u30eb\u3002\u30aa\u30d6\u30b8\u30a7\u30af\u30c8\u540d\u306f fphar-08-00289-g001.jpg\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/bin\/fphar-08-00289-g001.jpg\" alt=\"An external file that holds a picture, illustration, etc. Object name is fphar-08-00289-g001.jpg\" \/><\/div>\n<div id=\"lgnd_F1\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/figure\/F1\/\" target=\"figure\" rel=\"noopener\">\u56f31<\/a><\/div>\n<div class=\"caption\">\n<p><strong>\u30a8\u30ea\u30b2\u30ed\u30f3 \u30d6\u30ec\u30d3\u30b9\u30ab\u30d7\u30b9 (A)<\/strong>\u00a0\u82b1;\u00a0<strong>(B)<\/strong>\u00a0\u690d\u7269\u5168\u4f53\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p>\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306e\u7c97\u62bd\u51fa\u7269\u3067\u3059\u3002\u00a0<em>Erigeron breviscapus (Vant.) Hand.-Mazz.<\/em>\u00a0(<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B96\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f35\u3089\u30011988<\/a>\uff09 \u6ce8\u5c04\u5264\u3001\u9846\u7c92\u5264\u3001\u666e\u901a\u9320\u5264\u3001\u5206\u6563\u9320\u3001\u30ab\u30d7\u30bb\u30eb\u5264\u3001\u6df7\u5408\u5264\u3001\u70b9\u6ef4\u4e38\u5264\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B67\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30c6\u30a3\u30a2\u30f3\u3089\u30012014<\/a>\uff09\u3002\u79c1\u305f\u3061\u306e\u77e5\u308b\u9650\u308a\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u4e3b\u306a\u6709\u52b9\u6210\u5206\u306f\u30b9\u30af\u30c6\u30e9\u30ea\u30f3 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B96\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f35\u3089\u30011988<\/a>\uff09\u3002\u9ad8\u8840\u5727\u3001\u8133\u585e\u6813\u75c7\u3001\u8133\u8840\u7ba1\u969c\u5bb3\u306b\u3088\u308b\u9ebb\u75fa\u306e\u6cbb\u7642\u306e\u305f\u3081\u306e\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u4f7f\u7528\u306f 1970 \u5e74\u4ee3\u306b\u9061\u308a\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B92\" aria-expanded=\"false\" aria-haspopup=\"true\">\u96f2\u5357\u7701\u30de\u30c6\u30ea\u30a2\u30e1\u30c7\u30a3\u30ab\u7814\u7a76\u6240\u30011976 \u5e74<\/a>\uff09\u3002\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u8133\u6897\u585e\u3084\u7cd6\u5c3f\u75c5\u6027\u814e\u75c7\u306e\u6cbb\u7642\u306b\u4f7f\u7528\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30e9\u30f3\u30c0\u30e0\u5316\u304a\u3088\u3073\u6e96\u30e9\u30f3\u30c0\u30e0\u5316\u5bfe\u7167\u8a66\u9a13\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u3068\u65e5\u5e38\u7642\u6cd5\u3092\u4f75\u7528\u3057\u305f\u7642\u6cd5\u3068\u65e5\u5e38\u7642\u6cd5\u306e\u307f\u3092\u6bd4\u8f03\u3057\u3001\u60a3\u8005\u306e\u8ee2\u5e30\u306b\u5bfe\u3057\u3066\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u306e\u7d71\u8a08\u7684\u306b\u6709\u610f\u306a\u5229\u70b9\u304c\u793a\u3055\u308c\u3001\u9855\u8457\u306a\u795e\u7d4c\u5b66\u7684\u6539\u5584\u304c\u793a\u3055\u308c\u307e\u3057\u305f\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B88\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30e4\u30f3\u4ed6\u30012012<\/a>\uff09\u3002\u4e00\u65b9\u3001\u7cd6\u5c3f\u75c5\u6027\u672b\u68a2\u795e\u7d4c\u969c\u5bb3\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u3068\u30e1\u30b3\u30d0\u30e9\u30df\u30f3\u306e\u4f75\u7528\u7642\u6cd5\u306b\u95a2\u3059\u308b\u5225\u306e\u30e1\u30bf\u5206\u6790\u3067\u306f\u3001\u4f75\u7528\u7642\u6cd5\u306e\u6cbb\u7642\u52b9\u679c\u304c\u30e1\u30b3\u30d0\u30e9\u30df\u30f3\u5358\u72ec\u3088\u308a\u3082\u512a\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B33\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ea\u30e5\u30fc\u307b\u304b\u30012016<\/a>\uff09\u3002\u7cd6\u5c3f\u75c5\u6027\u814e\u75c7\u306e\u81e8\u5e8a\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u6ce8\u5c04\u306e\u52b9\u679c\u306b\u95a2\u3059\u308b\u5225\u306e\u30e1\u30bf\u5206\u6790 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B101\" aria-expanded=\"false\" aria-haspopup=\"true\">\u912d\u4ed6\u30012015<\/a>) \u306f\u3001\u9855\u8457\u306a\u814e\u4fdd\u8b77\u52b9\u679c (\u5c3f\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u8840\u6e05\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u3001\u8840\u4e2d\u5c3f\u7d20\u7a92\u7d20\u306e\u6e1b\u5c11) \u3068\u8102\u8cea\u7570\u5e38\u75c7\u306e\u8abf\u6574 (\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9 (TG)\u3001\u304a\u3088\u3073\u9ad8\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ec\u30d9\u30eb\u306b\u5bfe\u3059\u308b\u52b9\u679c) \u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002<\/p>\n<p class=\"p\">\u73fe\u5728\u3001\u305d\u306e\u5fc3\u8840\u7ba1\u85ac\u7406\u52b9\u679c\u306e\u305f\u3081 (<strong>\u30c6\u30fc\u30d6\u30eb\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/table\/T1\/\" target=\"table\" rel=\"noopener\">\u200b<span class=\"figpopup-sensitive-area\">\u88681\u3001<\/span>1<\/a>,\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/table\/T2\/\" target=\"table\" rel=\"noopener\">\u200b<span class=\"figpopup-sensitive-area\">,2<\/span>2<\/a><\/strong>) \u304a\u3088\u3073\u81e8\u5e8a\u4e0a\u306e\u5229\u70b9 (<strong>\u30c6\u30fc\u30d6\u30eb\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/table\/T3\/\" target=\"table\" rel=\"noopener\">\u200b<span class=\"figpopup-sensitive-area\">\u88683<\/span>3<\/a><\/strong>\uff09\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001\u4e2d\u56fd\u3067\u306f\u72ed\u5fc3\u75c7\u3084\u5fc3\u7b4b\u6897\u585e\uff08MI\uff09\u306a\u3069\u306e\u865a\u8840\u6027\u5fc3\u8840\u7ba1\u969c\u5bb3\u306e\u6cbb\u7642\u306b\u897f\u6d0b\u533b\u5b66\u3068\u4f75\u7528\u3057\u3066\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B4\" aria-expanded=\"false\" aria-haspopup=\"true\">\u66f9\u4ed6\u30012008<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B21\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f7c\u3089\u30012012<\/a>\uff09\u3002\u72ed\u5fc3\u75c7\u60a3\u8005\u306e\u88dc\u52a9\u7642\u6cd5\u3068\u3057\u3066\u306e\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306e\u30e1\u30bf\u5206\u6790\u3067\u306f\u3001\u5bfe\u7167\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u3001\u6cbb\u7642\u7fa4\u304c\u72ed\u5fc3\u75c7\u60a3\u8005\u3078\u306e\u5229\u76ca\u306b\u304a\u3044\u3066\u512a\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B47\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30cb\u30fc\u3089\u30012012<\/a>\uff09\u3002\u3055\u3089\u306b\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u4f5c\u7528\u306b\u3088\u308a\u3001\u8840\u7ba1\u62e1\u5f35\u3001\u6297\u8840\u6813\u4f5c\u7528\u3001\u8840\u5c0f\u677f\u51dd\u96c6\u3001\u6297\u51dd\u56fa\u3001\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u306e\u9664\u53bb\u3001\u5fae\u5c0f\u5faa\u74b0\u306e\u6539\u5584\u306a\u3069\u3001\u5e45\u5e83\u3044\u5fc3\u8840\u7ba1\u85ac\u7406\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<em>\u751f\u4f53\u5185<\/em>\u00a0\u305d\u3057\u3066\u00a0<em>\u8a66\u9a13\u7ba1\u5185\u3067<\/em>\u00a0\u5b9f\u9a13\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u4e00\u9023\u306e\u85ac\u7406\u5b66\u7684\u7279\u6027\u3092\u6301\u3061\u3001\u81e8\u5e8a\u73fe\u5834\u3067\u4f7f\u7528\u3067\u304d\u308b\u3044\u304f\u3064\u304b\u306e\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306e\u4e00\u7a2e\u306e\u6df7\u5408\u7269\u3067\u3059\u304c\u3001\u305d\u306e\u6839\u672c\u7684\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u307e\u3060\u4e0d\u660e\u3067\u3059\u3002<\/p>\n<div id=\"T1\" class=\"table-wrap anchored whole_rhythm\">\n<h3>\u88681<\/h3>\n<div class=\"caption\">\n<p><em>\u751f\u4f53\u5185<\/em>\u00a0\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u3068\u30b9\u30af\u30c6\u30e9\u30ea\u30f3\u306e\u5fc3\u8840\u7ba1\u3078\u306e\u5f71\u97ff\u3002<\/p>\n<\/div>\n<div class=\"xtable\">\n<table class=\"rendered small default_table\" frame=\"hsides\" rules=\"groups\" cellspacing=\"5\" cellpadding=\"5\">\n<thead>\n<tr>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u52b9\u679c<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5316\u5408\u7269<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u52d5\u7269\u30fb\u81d3\u5668<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u76ee\u6a19<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u53c2\u7167<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">I\/R\u306b\u5bfe\u3059\u308b\u4fdd\u8b77\u52b9\u679c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30b9\u30af\u30c6\u30e9\u30ea\u30f3\/\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u96c4\u306e\u30b9\u30d7\u30e9\u30fc\u30b0\u30c9\u30fc\u30ea\u30fc (SD) \u30e9\u30c3\u30c8<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u7b4b\u6897\u585e\uff08MI\uff09\u30b5\u30a4\u30ba\u306e\u5fc3\u7b4b\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3002<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B32\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ea\u30f3\u4ed6\u30012007<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">I\/R\u306b\u5bfe\u3059\u308b\u4fdd\u8b77\u52b9\u679c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">I\/R\u640d\u50b7\u30e9\u30c3\u30c8<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">PI3K\/Akt\/eNOS \u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3002<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B73\" aria-expanded=\"false\" aria-haspopup=\"true\">Wang J. \u4ed6\u30012015<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">I\/R\u306b\u5bfe\u3059\u308b\u4fdd\u8b77\u52b9\u679c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5de6\u5fc3I\/R\u30e9\u30c3\u30c8<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">IL-18 \u3068 ICAM-1<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B79\" aria-expanded=\"false\" aria-haspopup=\"true\">Wang Y. \u4ed6\u30012013<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6297\u708e\u75c7\u52b9\u679c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30cb\u30e5\u30fc\u30b8\u30fc\u30e9\u30f3\u30c9\u30a6\u30b5\u30ae\u306e\u5fc3\u7b4b I\/R<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30bf\u30f3\u30d1\u30af\u8cea TNF-\u03b1 \u304a\u3088\u3073 NF-\u03baB<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B99\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8d99\u30012010<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6297\u708e\u75c7\u52b9\u679c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">I\/R\u30e9\u30c3\u30c8<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30bf\u30f3\u30d1\u30af\u8cea TNF-\u03b1 \u304a\u3088\u3073 IL-6<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B15\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30b4\u30f3\u30b0\u3089\u30012013<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6297\u51dd\u56fa\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30de\u30a6\u30b9<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u51dd\u56fa\u6642\u9593 (CT);\u30d7\u30ed\u30c8\u30ed\u30f3\u30d3\u30f3\u6642\u9593 (PT);\u8840\u5c0f\u677f\u7b2c III \u56e0\u5b50 (PF3);\u30e6\u30fc\u30b0\u30ed\u30d6\u30ea\u30f3\u6eb6\u89e3\u6642\u9593 (ELT)<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B80\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ef\u30f3\u4ed6\u30012003<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6297\u8840\u6813\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><em>\u30a8\u30ea\u30b2\u30ed\u30f3\u30fb\u30d6\u30ec\u30d3\u30b9\u30ab\u30d7\u30b9<\/em>\u00a0\u30d5\u30e9\u30dc\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30cd\u30ba\u30df\u30fb\u30a6\u30b5\u30ae<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">ADP\u3001AA\u3001\u8840\u5c0f\u677f\u6d3b\u6027\u5316\u56e0\u5b50 (PAF)<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B61\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30b7\u30a7\u30f3\u3089\u30012000<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6297\u8840\u6813\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30b9\u30af\u30c6\u30e9\u30e9\u30a4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30cd\u30ba\u30df<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">ADP \u8a98\u767a\u8840\u5c0f\u677f<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B64\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30bd\u30f3\u30b0\u4ed6\u30012011<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5185\u76ae\u4fdd\u8b77\u52b9\u679c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30c7\u30f3\u30b8\u30e3\u30f3\u30fb\u30b7\u30b7\u30f3\u6ce8\u5c04<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30a6\u30a3\u30b9\u30bf\u30fc\u30cd\u30ba\u30df<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">TNF-\u03b1;\u708e\u75c7\u53cd\u5fdc<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B94\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f35\u4ed6\u30012009<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u7b4b\u4fdd\u8b77\u52b9\u679c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30de\u30a6\u30b9\u306b\u304a\u3051\u308b\u5727\u529b\u904e\u8ca0\u8377\u8a98\u767a\u6027\u5fc3\u80a5\u5927<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">PKC \u30a2\u30eb\u30d5\u30a1\u4f9d\u5b58\u6027 ERK1\/2 PI3K\/AKT \u30b7\u30b0\u30ca\u30eb\u4f1d\u9054<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B86\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30e4\u30f3\u307b\u304b\u30012010<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u7b4b\u4fdd\u8b77\u52b9\u679c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30b9\u30af\u30c6\u30e9\u30ea\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30cd\u30ba\u30df<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u81d3\u5185\u76ae\u9593\u8449\u79fb\u884c Notch \u7d4c\u8def<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B104\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5468\u307b\u304b\u30012014<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u7b4b\u4fdd\u8b77\u52b9\u679c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30b9\u30c8\u30ec\u30d7\u30c8\u30be\u30c8\u30b7\u30f3\u8a98\u767a\u7cd6\u5c3f\u75c5\u30e9\u30c3\u30c8<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bcC (PKC);\u30db\u30b9\u30db\u30e9\u30f3\u30d0\u30f3 (PLB);\u30d7\u30ed\u30c6\u30a4\u30f3\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc\u963b\u5bb3\u5264-1 (PPI-1); Ca(2+)-ATP\u30a2\u30fc\u30bc (SERCA-2);\u30ea\u30a2\u30ce\u30b8\u30f3\u53d7\u5bb9\u4f53 (RyR)<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B77\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ef\u30f3\u4ed6\u30012010<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6297\u5fc3\u81d3\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u52b9\u679c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u4e0d\u5168\u30e9\u30c3\u30c8<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u7b4b\u306e\u53ce\u7e2e\u6a5f\u80fd\u3068\u62e1\u5f35\u6a5f\u80fd<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B30\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ea\u30fc\u30012011<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u8102\u8cea\u4f4e\u4e0b\u52b9\u679c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u7cd6\u5c3f\u75c5\u30e9\u30c3\u30c8<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u8840\u4e2d\u8102\u8cea<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B81\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30a6\u30a7\u30a4\u3089\u30012010<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u8102\u8cea\u4f4e\u4e0b\u52b9\u679c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30a6\u30b5\u30ae<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5185\u819c\u904e\u5f62\u6210\u3068\u52d5\u8108\u786c\u5316\u306e\u9032\u884c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B37\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30eb\u30fc\u3068\u30ea\u30e5\u30fc\u30012009<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u52c3\u8d77\u6a5f\u80fd\u306e\u6539\u5584<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u81ea\u7136\u767a\u75c7\u9ad8\u8840\u5727\u30e9\u30c3\u30c8 (SHR)<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">RhoA\/Rho\u30ad\u30ca\u30fc\u30bc\u7d4c\u8def<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B29\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ea\u30fc\u3089\u30012014<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div id=\"largeobj_idm140218659817184\" class=\"largeobj-link align_right\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/table\/T1\/?report=objectonly\" target=\"object\" rel=\"noopener\">\u5225\u30a6\u30a3\u30f3\u30c9\u30a6\u3067\u958b\u304d\u307e\u3059<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<div><\/div>\n<div><\/div>\n<div id=\"abstract-a.k.b.n\" class=\"tsec sec\" lang=\"en\">\n<div id=\"sec-a.l.a\" class=\"tsec sec\">\n<div id=\"T2\" class=\"table-wrap anchored whole_rhythm\">\n<h3>\u88682<\/h3>\n<div class=\"caption\">\n<p><em>\u8a66\u9a13\u7ba1\u5185\u3067<\/em>\u00a0\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u3068\u30b9\u30af\u30c6\u30e9\u30ea\u30f3\u306e\u5fc3\u8840\u7ba1\u3078\u306e\u5f71\u97ff\u3002<\/p>\n<\/div>\n<div class=\"xtable\">\n<table class=\"rendered small default_table\" frame=\"hsides\" rules=\"groups\" cellspacing=\"5\" cellpadding=\"5\">\n<thead>\n<tr>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u52b9\u679c<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5316\u5408\u7269<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u7d30\u80de\/\u7d44\u7e54<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u76ee\u6a19<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u53c2\u7167<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u8840\u7ba1\u62e1\u5f35\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30e9\u30c3\u30c8\u5927\u52d5\u8108\u5e73\u6ed1\u7b4b\u7d30\u80de (ASMC)<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">Ca2+ \u4f9d\u5b58\u6027 K+ \u30c1\u30e3\u30cd\u30eb \u30c1\u30e3\u30cd\u30eb\u958b\u653e\u78ba\u7387 (Po) \u30c1\u30e3\u30cd\u30eb \u30b3\u30f3\u30c0\u30af\u30bf\u30f3\u30b9<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B84\" aria-expanded=\"false\" aria-haspopup=\"true\">\u79c0\u7434\u30012006<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">I\/R\u306b\u5bfe\u3059\u308b\u4fdd\u8b77\u52b9\u679c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u8840\u6e05\u304a\u3088\u3073\u5fc3\u7b4b\u7d44\u7e54<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u7b4b\u306e ICAM-1 \u30bf\u30f3\u30d1\u30af\u8cea Na(+)-K(+)-ATPase\u3001Mg(2+)-ATPase\u3001\u5fc3\u7b4b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e Ca(2+)-ATPase<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B23\" aria-expanded=\"false\" aria-haspopup=\"true\">Jia \u4ed6\u30012008<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6297\u51dd\u56fa\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5185\u76ae\u7d30\u80de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30c8\u30ed\u30f3\u30dc\u30e2\u30b8\u30e5\u30ea\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B105\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5468\u3089\u30011992<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5185\u76ae\u4fdd\u8b77\u52b9\u679c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d2\u30c8\u81cd\u5e2f\u9759\u8108\u5185\u76ae\u7d30\u80de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6297\u9178\u5316\u4f5c\u7528; NF-\u03baB\u306e\u6d3b\u6027\u5316<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B5\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30c1\u30a7\u30f3\u4ed6\u30012015<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5185\u76ae\u4fdd\u8b77\u52b9\u679c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30b9\u30af\u30c6\u30e9\u30ea\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d2\u30c8\u81cd\u5e2f\u9759\u8108\u5185\u76ae\u7d30\u80de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">VEGF\u306e\u5897\u52a0<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B31\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ea\u30f3\u4ed6\u30012011<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u7b4b\u4fdd\u8b77\u52b9\u679c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u4f4e\u9178\u7d20\u72b6\u614b\u306b\u3055\u3089\u3055\u308c\u305f\u5fc3\u7b4b\u7d30\u80de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">LDH \u6f0f\u51fa \u7d30\u80de\u5185\u904a\u96e2 Ca2+ \u30ec\u30d9\u30eb \u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u58ca\u6b7b<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B28\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ea\u30fc\u3089\u30012004<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u7b4b\u4fdd\u8b77\u52b9\u679c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u57f9\u990a\u65b0\u751f\u30e9\u30c3\u30c8\u5fc3\u7b4b\u7d30\u80de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">PKC-\u03b1\u4f9d\u5b58\u6027ERK1\/2; PI3K\/AKT\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B86\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30e4\u30f3\u307b\u304b\u30012010<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5e73\u6ed1\u7b4b\u7d30\u80de\u306e\u79fb\u52d5\u3068\u5897\u6b96\u306e\u6e1b\u5c11<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30e9\u30c3\u30c8\u5927\u52d5\u8108\u5e73\u6ed1\u7b4b\u7d30\u80de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30c8\u30ed\u30f3\u30d3\u30f3\/\u30c8\u30ed\u30f3\u30d3\u30f3\u53d7\u5bb9\u4f53\u907a\u4f1d\u5b50<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B22\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30db\u30a6\u4ed6\u30012009<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5e73\u6ed1\u7b4b\u7d30\u80de\u306e\u79fb\u52d5\u3068\u5897\u6b96\u306e\u6e1b\u5c11<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30a6\u30b5\u30ae\u8840\u7ba1\u5e73\u6ed1\u7b4b\u7d30\u80de\uff08VSMC\uff09<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">VSMC\u306eNF-\u03baB\u6d3b\u6027<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B49\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30d1\u30f3\u4ed6\u30012004<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5e73\u6ed1\u7b4b\u7d30\u80de\u306e\u79fb\u52d5\u3068\u5897\u6b96\u306e\u6e1b\u5c11<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">VSMC<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">ERK1\/2 MAPK \u30b7\u30b0\u30ca\u30ea\u30f3\u30b0<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B21\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f7c\u3089\u30012012<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6297\u4e0d\u6574\u8108\u52b9\u679c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30e9\u30c3\u30c8\u5fc3\u5ba4\u7b4b\u7d30\u80de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30ab\u30ea\u30a6\u30e0\u96fb\u6d41\uff08\u4f0a\u85e4\uff09<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B6\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30c7\u30f3\u4ed6\u30012008<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6297\u4e0d\u6574\u8108\u52b9\u679c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30e9\u30c3\u30c8\u5fc3\u5ba4\u7b4b\u7d30\u80de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">INa\u30c1\u30e3\u30cd\u30eb\u96fb\u6d41<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B65\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30bf\u30f3\u4ed6\u30012009<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u8840\u7ba1\u62e1\u5f35\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30e9\u30c3\u30c8\u306e\u5206\u96e2\u3055\u308c\u305f\u80f8\u90e8\u5927\u52d5\u8108\u8f2a<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u53d7\u5bb9\u4f53\u4f5c\u52d5\u6027\u30ab\u30eb\u30b7\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B102\" aria-expanded=\"false\" aria-haspopup=\"true\">\u912d\u4ed6\u30011998<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6297\u4e0d\u6574\u8108\u52b9\u679c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u80a5\u5927\u5316\u3057\u305f\u30a6\u30b5\u30ae\u306e\u5fc3\u81d3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u7d4c\u58c1\u518d\u5206\u6975\u5206\u6563\u3002 (TDR) \u8131\u5206\u6975\u5f8c\u306e\u65e9\u671f\u3002 (EAD) \u30c8\u30eb\u30b5\u30fc\u30c9\u30fb\u30c9\u30fb\u30dd\u30ef\u30f3\u30c8\u3002 (TDP)<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B1\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30dc\u30fc\u4ed6\u30012011<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div id=\"largeobj_idm140218663351120\" class=\"largeobj-link align_right\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/table\/T2\/?report=objectonly\" target=\"object\" rel=\"noopener\">\u5225\u30a6\u30a3\u30f3\u30c9\u30a6\u3067\u958b\u304d\u307e\u3059<\/a><\/div>\n<div><\/div>\n<\/div>\n<div id=\"T3\" class=\"table-wrap anchored whole_rhythm\">\n<h3>\u88683<\/h3>\n<div class=\"caption\">\n<p>\u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u8a66\u9a13\u3082\u542b\u307e\u308c\u307e\u3059\u3002<\/p>\n<\/div>\n<div class=\"xtable\">\n<table class=\"rendered small default_table\" frame=\"hsides\" rules=\"groups\" cellspacing=\"5\" cellpadding=\"5\">\n<thead>\n<tr>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u76ee\u6a19<sup>\u3042\u308b<\/sup><\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u30c7\u30b6\u30a4\u30f3<sup>b<\/sup><\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u9593\u9694<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u7528\u91cf<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u30b1\u30fc\u30b9\/\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u4e3b\u306a\u7d50\u679c\u306e\u5c3a\u5ea6<sup>c<\/sup><\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u53c2\u7167<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">SAP<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">RCT<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">14\u65e5\u9593<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">40mg\u30011\u65e53\u56de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">25\/25<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5178\u578b\u7684\u306a\u75c7\u72b6\u3001ECG \u306b\u304a\u3051\u308b ST-T \u306e\u6539\u5584\u3068\u52d5\u7684\u5fc3\u96fb\u56f3\u306b\u304a\u3051\u308b ST-T \u306e\u6642\u9593<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B95\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f35\u3068\u5f35\u30012012<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">UAP<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">RCT<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">2\u9031\u9593<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">20ml\u3001qd<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">53\/51<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u785d\u9178\u30a4\u30bd\u30bd\u30eb\u30d3\u30c9\u306e\u6295\u4e0e\u91cf\u3001\u5fc3\u96fb\u56f3\u6cbb\u7642\u52b9\u679c\u3001WBHV\u3001PV\u3001FIB\u3001hs-CRP\u3001\u8d64\u8840\u7403\u51dd\u96c6\u6307\u6570<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B60\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30b7\u30a7\u30f3\u3089\u30012014<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30a2\u30df<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">CCT<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">10\u65e5\u9593<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">60mg\u30011\u65e53\u56de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">25\/20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">LVEF\u3001\u672b\u68a2\u8840\u7ba1\u62b5\u6297\u304a\u3088\u3073\u72ed\u5fc3\u75c7\u5f8c\u767a\u75c7\u7387<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B18\" aria-expanded=\"false\" aria-haspopup=\"true\">Gu TB \u4ed6\u30012002<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30a2\u30df<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">RCT<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">14\u65e5\u9593<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">100mg\u3001qd<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">60\/60<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u6a5f\u80fd\u306e\u6539\u5584\u3001\u5fc3\u81d3\u6709\u5bb3\u4e8b\u8c61\u306e\u767a\u751f\u7387<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B87\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30e4\u30f3\u3068\u30c1\u30a7\u30f3\u30012013<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30a2\u30df<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">RCT<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">14\u65e5\u9593<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">50mg\u30011\u65e53\u56de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">54\/54<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u904b\u52d5\u8a98\u767a\u6027\u5fc3\u96fb\u56f3ST\u4f4e\u4e0b\u6642\u9593\u3001ST\u4f4e\u4e0b\u671f\u9593\u306e\u77ed\u7e2e<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B76\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ef\u30f3\u4ed6\u30012009<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u3048\u30fc<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">RCT<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">4\uff5e6\u9031\u9593<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">40ml\u3001qd<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">25\/25<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5c3f\u4e2dNAG\u91cf\u3068\u03b2\u5024<sub>2<\/sub>-MG\u3001\u8840\u5727<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B72\" aria-expanded=\"false\" aria-haspopup=\"true\">\u738b\u30012000<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u3042\u30fc\u3061<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">RCT<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">14\u65e5\u9593<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">10ml\u3001qd<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">39\/39<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u8840\u816b\u91cf\u3001\u6d6e\u816b\u9762\u7a4d\u3001\u30b9\u30ab\u30f3\u30b8\u30ca\u30d3\u30a2\u8133\u5352\u4e2d\u30b9\u30b1\u30fc\u30eb (SSS)<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B63\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30b7\u30fc\u3068\u30c7\u30a3\u30f3\u30012009<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">AF<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u30b1\u30fc\u30b9\u30b7\u30ea\u30fc\u30ba<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">2\u9031\u9593<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">36mg\u30011\u65e53\u56de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">20\/-<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u62cd\u6570<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B19\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30cf\u30f3\u30011999<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u9ad8\u8102\u8840\u75c7<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u30b1\u30fc\u30b9\u30b7\u30ea\u30fc\u30ba<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">2\u9031\u9593<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">25 mg\u3001\u4e00\u65e5\u3054\u3068<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">25\/-<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">TC\u3001LDL-c\u3001HDL-c\u3001TG<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B91\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30e6\u30a6\u30012011<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u9ad8\u8102\u8840\u75c7<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u30b1\u30fc\u30b9\u30b7\u30ea\u30fc\u30ba<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">4\u9031\u9593<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">30ml\u3001qd<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">36\/-<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">TC\u3001LDL-c\u3001HDL-c\u3001TG<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B82\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30a6\u30a7\u30f3\u3068\u30eb\u30a2\u30f3\u30012004<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">UPA\u3068\u9ad8\u8102\u8840\u75c7<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">RCT<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">2\u9031\u9593<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">50mg\u30011\u65e53\u56de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">30\/32<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u8840\u6e05\u8102\u8cea\u3001WBV\u3001PV\u3001\u72ed\u5fc3\u75c7\u306e\u6642\u671f<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B51\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30da\u30f3\u3068\u30a4\u30a7\u30012011<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30a6\u30a4\u30eb\u30b9\u6027\u5fc3\u7b4b\u708e<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">CCT<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">2\u9031\u9593<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">10mg\u3001qd<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">40\/30<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">DC\u3001CK-MB<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B17\" aria-expanded=\"false\" aria-haspopup=\"true\">Gu \u4ed6\u30012014<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u30a6\u30a4\u30eb\u30b9\u6027\u5fc3\u7b4b\u708e<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">RCT<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">2\u9031\u9593<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">10mg\u3001qd<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">30\/30<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">TNF-\u03b1<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B78\" aria-expanded=\"false\" aria-haspopup=\"true\">\u738b\u3068\u738b\u30012009<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">HF-NEF<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">RCT<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">10\u65e5\u9593<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">40mg\u30011\u65e53\u56de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">50\/50<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">BNP\u3001LVEF\u3001LVEDV\u3001\u4ee3\u8868\u7684\u306a\u75c7\u72b6<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B93\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f35 F.\u30012014<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">HF<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">RCT<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">14\u65e5\u9593<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">50mg\u30011\u65e53\u56de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">64\/62<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">LVEF\u30016-MWT<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B68\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30c6\u30a3\u30a2\u30f3\u30012010<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u91cd\u5ea6\u306e\u5fc3\u4e0d\u5168<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">CCT<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">14\u65e5\u9593<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">50mg\u30011\u65e53\u56de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">46\/23<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">LVEF\u3001LVEDV\u30016-MWT<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B27\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ea\u30fc\u30012007<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u535a\u58eb<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">RCT<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">28\u65e5<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">40mg\u30011\u65e53\u56de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">42\/41<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">bFGF\u3001PaO<sub>2<\/sub>\u3001mPAP<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B13\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ac\u30aa\u3068\u30ea\u30e3\u30f3\u30012009<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u975e\u4ee3\u511f\u6027\u6162\u6027PHD<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">CCT<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">20\u65e5\u9593<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">50mg\u30011\u65e53\u56de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">38\/46<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u8d64\u8840\u7403\u306e\u5909\u5f62\u80fd\u3068\u767d\u8840\u7403\u6d3b\u6027\u5316\u80fd<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B25\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30b3\u30f3\u30b0\u4ed6\u30012006<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">PHD\u306e\u6025\u6027\u5897\u60aa<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">CCT<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">2\u9031\u9593<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">20mg\u3001\u4e00\u65e5\u3054\u3068<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">104\/104<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">WBV\u3001FIB\u3001\u4ee3\u8868\u7684\u306a\u75c7\u72b6<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B3\" aria-expanded=\"false\" aria-haspopup=\"true\">\u66f9\u4ed6\u30012006<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div id=\"largeobj_idm140218699722016\" class=\"largeobj-link align_right\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/table\/T3\/?report=objectonly\" target=\"object\" rel=\"noopener\">\u5225\u30a6\u30a3\u30f3\u30c9\u30a6\u3067\u958b\u304d\u307e\u3059<\/a><\/div>\n<div class=\"tblwrap-foot\">\n<div class=\"half_rhythm align_right attrib\">\n<p>&nbsp;<\/p>\n<p><sup>\u3042\u308b<\/sup>SAP\u3001\u5b89\u5b9a\u72ed\u5fc3\u75c7\u3002 UAP\u3001\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u3002 AMI\u3001\u6025\u6027\u5fc3\u7b4b\u6897\u585e\u3002 EH\u3001\u672c\u614b\u6027\u9ad8\u8840\u5727\u3002 AHCH\u3001\u6025\u6027\u9ad8\u8840\u5727\u6027\u8133\u51fa\u8840\u3002 AF\u3001\u5fc3\u623f\u7d30\u52d5\u3002 HF\u3001\u5fc3\u4e0d\u5168\u3002 HF-NEF\u3001\u6b63\u5e38\u99c6\u51fa\u7387\u3092\u4f34\u3046\u5fc3\u4e0d\u5168\u3002 PHD\u3001\u80ba\u5fc3\u75be\u60a3\u3002\u00a0<sup>b<\/sup>RCT\u3001\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3002 CCT\u3001\u81e8\u5e8a\u5bfe\u7167\u8a66\u9a13\u3002\u00a0<sup>c<\/sup>WBV\u3001\u5168\u8840\u7c98\u5ea6\u3002 PV\u3001\u8840\u6f3f\u7c98\u5ea6\u3002 FIB\u3001\u30d5\u30a3\u30d6\u30ea\u30ce\u30fc\u30b2\u30f3\u3002 WBHV\u3001\u5168\u8840\u9ad8\u7c98\u5ea6\u3002 LVEF\u3001\u5de6\u5fc3\u5ba4\u99c6\u51fa\u7387\u3002 TC\u3001\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3002 TG\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3002 DC\u3001\u6e1b\u901f\u80fd\u529b\u3002 LVEDV\u3001\u5de6\u5fc3\u5ba4\u62e1\u5f35\u7d42\u671f\u5bb9\u7a4d\u3002 6-MWT\u30016\u5206\u9593\u306e\u6b69\u884c\u30c6\u30b9\u30c8\u3002 bFGF\u3001\u5869\u57fa\u6027\u7dda\u7dad\u82bd\u7d30\u80de\u5897\u6b96\u56e0\u5b50\u3002\u30d1\u30aa<sub>2<\/sub>\u3001\u9178\u7d20\u5206\u5727\u3002 mPAP\u3001\u5e73\u5747\u80ba\u52d5\u8108\u5727\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div><\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"sec-a.l.b\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"sec-a.l.btitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u65b9\u6cd5\u8ad6<\/h2>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">PubMed \u304a\u3088\u3073 SinoMed \u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306f\u3001\u300cBreviscapine\u300d\u307e\u305f\u306f\u300c<em>\u30a8\u30ea\u30b2\u30ed\u30f3\u30fb\u30d6\u30ec\u30d3\u30b9\u30ab\u30d7\u30b9<\/em>&quot; \u307e\u305f\u306f &quot;<em>\u30cf\u30fc\u30d0\u30fb\u30a8\u30ea\u30b2\u30ed\u30f3\u30c6\u30a3\u30b9<\/em>&quot; \u307e\u305f\u306f &quot;<em>\u30e9\u30f3\u30d7\u83ca<\/em>\u300d\u307e\u305f\u306f\u300c\u30b9\u30af\u30c6\u30e9\u30ea\u30f3\u300d\u307e\u305f\u306f\u300c\u30a2\u30d4\u30b2\u30cb\u30f3-7-\u300d<em>\u25cb<\/em>\u300c\u30bf\u30a4\u30c8\u30eb\/\u8981\u7d04\u300d\u3068\u3057\u3066\u300c-glucuronide\u300d\u307e\u305f\u306f\u300cdengzhanxixin\u300d\u3001\u307e\u305f\u306f MeSH \u7528\u8a9e\u300cBreviscapine\u300d\u307e\u305f\u306f\u300cscutellarin-7-\u300d<em>\u25cb<\/em>-\u30b0\u30eb\u30af\u30ed\u30cb\u30c9\u300d\u3002\u5fc3\u8840\u7ba1\u75be\u60a3\uff08CVD\uff09\u306e\u6cbb\u7642\u52b9\u679c\u306b\u95a2\u9023\u3059\u308b\u8a18\u4e8b\u3092\u624b\u52d5\u3067\u9078\u629e\u3057\u307e\u3057\u305f\u3002\u8981\u7d04\u4ed8\u304d\u306e\u3059\u3079\u3066\u306e\u8a18\u4e8b\u304c\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u8a00\u8a9e\u5236\u9650\u306f\u9069\u7528\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.c\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"sec-a.l.ctitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u5316\u5b66\u6210\u5206<\/h2>\n<p>&nbsp;<\/p>\n<p class=\"p p-first\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306b\u306f\u4e3b\u306b\u30b9\u30af\u30c6\u30e9\u30ea\u30f3 (4&#039;,5,6,7-\u30c6\u30c8\u30e9\u30d2\u30c9\u30ed\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3-7-) \u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002<em>\u25cb<\/em>-\u30b0\u30eb\u30af\u30ed\u30cb\u30c9) \u304a\u3088\u3073\u30a2\u30d4\u30b2\u30cb\u30f3-7-<em>\u25cb<\/em>-\u30b0\u30eb\u30af\u30ed\u30cb\u30c9\u3002\u30b9\u30af\u30c6\u30e9\u30ea\u30f3\u304c\u4e3b\u306a\u6709\u52b9\u6210\u5206\u3067\u3059\u3002\u305d\u306e\u5206\u5b50\u5f0f\u306fC\u3067\u3059<sub>21<\/sub>H<sub>18<\/sub>\u25cb<sub>12<\/sub>\u3001\u305d\u306e\u76f8\u5bfe\u5206\u5b50\u91cf\u306f 462.35 \u3067\u3059\u3002\u305d\u306e\u5316\u5b66\u69cb\u9020\u306f\u6b21\u306e\u3068\u304a\u308a\u3067\u3059\u3002\u00a0<strong>\u5f62\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\u200b<span class=\"figpopup-sensitive-area\">\u56f32<\/span>2<\/a><\/strong>\u3002\u3057\u304b\u3057\u3001\u30b9\u30af\u30c6\u30e9\u30ea\u30f3\u306f\u6c34\u6eb6\u89e3\u5ea6\u304c\u4f4e\u304f\u3001\u5316\u5b66\u7684\u5b89\u5b9a\u6027\u304c\u4f4e\u304f\u3001\u751f\u7269\u5b66\u7684\u534a\u6e1b\u671f\u304c\u77ed\u304f\u3001\u8840\u6f3f\u304b\u3089\u306e\u6392\u51fa\u901f\u5ea6\u304c\u901f\u3044\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B20\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30cf\u30aa\u3089\u30012005<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B38\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30eb\u30fc\u4ed6\u30012010<\/a>\uff09\u3002\u30a2\u30d4\u30b2\u30cb\u30f3-7-\u306e\u5316\u5b66\u69cb\u9020<em>\u25cb<\/em>-\u30b0\u30eb\u30af\u30ed\u30cb\u30c9\u306f\u4ee5\u4e0b\u306b\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u00a0<strong>\u5f62\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/figure\/F3\/\" target=\"figure\" rel=\"noopener\">\u200b<span class=\"figpopup-sensitive-area\">\u56f33<\/span>3<\/a><\/strong>;\u305d\u306e\u5206\u5b50\u5f0f\u306fC\u3067\u3059<sub>21<\/sub>H<sub>18<\/sub>\u25cb<sub>11<\/sub>\u00a0\u76f8\u5bfe\u5206\u5b50\u91cf\u306f 446 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B83\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30a6\u30fc\u30012011<\/a>).<\/p>\n<div id=\"F2\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm140218698629024\"><img decoding=\"async\" class=\"fig-image\" title=\"\u5199\u771f\u3001\u30a4\u30e9\u30b9\u30c8\u306a\u3069\u3092\u4fdd\u6301\u3059\u308b\u5916\u90e8\u30d5\u30a1\u30a4\u30eb\u3002\u30aa\u30d6\u30b8\u30a7\u30af\u30c8\u540d\u306f fphar-08-00289-g002.jpg\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/bin\/fphar-08-00289-g002.jpg\" alt=\"An external file that holds a picture, illustration, etc. Object name is fphar-08-00289-g002.jpg\" \/><\/div>\n<div id=\"lgnd_F2\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\u56f32<\/a><\/div>\n<div class=\"caption\">\n<p><strong>\u30b9\u30af\u30c6\u30e9\u30ea\u30f3\u306e\u69cb\u9020<\/strong>.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"F3\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm140218698625760\"><img decoding=\"async\" class=\"fig-image\" title=\"\u5199\u771f\u3001\u30a4\u30e9\u30b9\u30c8\u306a\u3069\u3092\u4fdd\u6301\u3059\u308b\u5916\u90e8\u30d5\u30a1\u30a4\u30eb\u3002\u30aa\u30d6\u30b8\u30a7\u30af\u30c8\u540d\u306f fphar-08-00289-g003.jpg\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/bin\/fphar-08-00289-g003.jpg\" alt=\"An external file that holds a picture, illustration, etc. Object name is fphar-08-00289-g003.jpg\" \/><\/div>\n<div id=\"lgnd_F3\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/figure\/F3\/\" target=\"figure\" rel=\"noopener\">\u56f33<\/a><\/div>\n<div class=\"caption\">\n<p><strong>\u30a2\u30d4\u30b2\u30cb\u30f3\u306e\u69cb\u9020-7-<em>\u25cb<\/em>-\u30b0\u30eb\u30af\u30ed\u30cb\u30c9<\/strong>.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"sec-a.l.d\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"sec-a.l.dtitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u5fc3\u81d3\u8840\u7ba1\u3078\u306e\u5f71\u97ff<\/h2>\n<div id=\"sec-a.l.d.b\" class=\"sec sec-first\">\n<h3 id=\"sec-a.l.d.btitle\">\u8840\u7ba1\u62e1\u5f35\u52b9\u679c<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u8840\u7ba1\u6052\u5e38\u6027\u3092\u7dad\u6301\u3059\u308b\u6a5f\u80fd\u3092\u5b9f\u884c\u3059\u308b\u8840\u7ba1\u69cb\u9020\u306f\u3001\u8840\u5727\u306e\u7dad\u6301\u3068\u3001\u52d5\u7684\u306a\u8eab\u4f53\u72b6\u614b\u306b\u5fdc\u3058\u305f\u9069\u5207\u306a\u8840\u6db2\u704c\u6d41\u306e\u63d0\u4f9b\u306e\u4e21\u65b9\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u305d\u306e\u8abf\u7bc0\u6a5f\u69cb\u306e 1 \u3064\u3068\u3057\u3066\u3001\u8840\u7ba1\u5e73\u6ed1\u7b4b (VSM) \u306e\u5f1b\u7de9\u306f\u3001\u4e00\u9023\u306e\u5185\u76ae\u4f9d\u5b58\u6027\u304a\u3088\u3073\u5185\u76ae\u975e\u4f9d\u5b58\u6027\u56e0\u5b50\u306e\u653e\u51fa\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u3001\u03b1 \u53d7\u5bb9\u4f53\u3001\u03b2 \u53d7\u5bb9\u4f53\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u8a3c\u660e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u53d7\u5bb9\u4f53\u3001Ca<sup>2+<\/sup>\u00a0\u30c1\u30e3\u30cd\u30eb\u3068Ca<sup>2+<\/sup>-\u4f9d\u5b58K<sup>+<\/sup>\u00a0\u7d30\u80de\u819c\u4e0a\u306e\u30c1\u30e3\u30cd\u30eb\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B12\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30d5\u30eb\u30c1\u30b4\u30c3\u30c8\u30011983\u5e74<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B54\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30e9\u30dd\u30dd\u30fc\u30c8\u3089\u30011983<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B66\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30bf\u30ec\u3089\u30011990<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B2\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30dc\u30ed\u30c6\u30a3\u30ca\u3089\u30011994<\/a>\uff09\u3002\u306b\u57fa\u3065\u304f\u00a0<em>\u8a66\u9a13\u7ba1\u5185\u3067<\/em>\u00a0\u7814\u7a76\u306b\u3088\u308c\u3070\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001\u8840\u7ba1\u62e1\u5f35\u52b9\u679c\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u5185\u76ae\u306e\u6a5f\u80fd\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u306a\u304f\u3001\u03b1\u53d7\u5bb9\u4f53\u3068\u03b2\u53d7\u5bb9\u4f53\u3092\u8abf\u6574\u3059\u308b\u3053\u3068\u306a\u304f\u3001\u6fc3\u5ea6\u4f9d\u5b58\u7684\u306b\u30ce\u30eb\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u8a98\u767a\u6027\u8840\u7ba1\u53ce\u7e2e\u3092\u7de9\u548c\u3067\u304d\u308b\u3068\u7d50\u8ad6\u3065\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u53d7\u5bb9\u4f53\u4f5c\u52d5\u6027\u30ab\u30eb\u30b7\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u306e\u963b\u5bb3\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B102\" aria-expanded=\"false\" aria-haspopup=\"true\">\u912d\u4ed6\u30011998<\/a>\uff09\u3002\u3082\u3046\u4e00\u3064\u306e...\u304c\u3042\u308b\u00a0<em>\u751f\u4f53\u5185<\/em>\u00a0\u30ab\u30eb\u30b7\u30a6\u30e0\u304c\u30ab\u30ea\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3092\u793a\u3059\u7814\u7a76 (K<sub>Ca<\/sub>\uff09\u30e9\u30c3\u30c8\u5927\u52d5\u8108\u5e73\u6ed1\u7b4b\u7d30\u80de\uff08ASMC\uff09\u306b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u3092\u9069\u7528\u3059\u308b\u3068\u3001\u30c1\u30e3\u30cd\u30eb\u306e\u958b\u653e\u78ba\u7387\uff08Po\uff09\u3092\u4fc3\u9032\u3057\u3001\u30c1\u30e3\u30cd\u30eb\u30b3\u30f3\u30c0\u30af\u30bf\u30f3\u30b9\u3092\u5f37\u5316\u3059\u308b\u3053\u3068\u3067\u6d3b\u6027\u5316\u3067\u304d\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B84\" aria-expanded=\"false\" aria-haspopup=\"true\">\u79c0\u7434\u30012006<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.d.c\" class=\"sec\">\n<h3 id=\"sec-a.l.d.ctitle\">\u865a\u8840\/\u518d\u704c\u6d41\uff08I\/R\uff09\u306b\u5bfe\u3059\u308b\u4fdd\u8b77\u52b9\u679c<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">I\/R \u50b7\u5bb3\u306f\u591a\u304f\u306e\u5834\u5408\u3001\u5185\u76ae\u969c\u5bb3\u306e\u60aa\u5316\u3068\u3057\u3066\u73fe\u308c\u3001\u5fc3\u7b4b\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u307e\u305f\u306f\u6b7b\u306e\u52a0\u901f\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002\u3053\u308c\u306f MI \u306e\u30b5\u30a4\u30ba\u306b\u3088\u3063\u3066\u6e2c\u5b9a\u3067\u304d\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B24\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30b3\u30f3\u30b0\u4ed6\u30012016<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B90\" aria-expanded=\"false\" aria-haspopup=\"true\">Yu \u4ed6\u30012016<\/a>\uff09\u3002\u7814\u7a76\u3067\u306f\u3001\u5fc3\u8840\u7ba1\u865a\u8840\u306b\u5bfe\u3059\u308b\u30b9\u30af\u30c6\u30e9\u30ea\u30f3\u5358\u72ec\u306e\u4fdd\u8b77\u52b9\u679c\u306f\u3001MI\u30e9\u30c3\u30c8\u306eMI\u30b5\u30a4\u30ba\u304a\u3088\u3073\u5fc3\u7b4b\u7d30\u80de\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306b\u95a2\u3057\u3066\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u3088\u308a\u3082\u512a\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u52b9\u679c\u306f\u7528\u91cf\u306b\u4f9d\u5b58\u3059\u308b\u3053\u3068\u304c\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B32\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ea\u30f3\u4ed6\u30012007<\/a>\uff09\u3002\u5fc3\u7b4bI\/R\u640d\u50b7\u306e\u767a\u75c7\u306b\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u7279\u5b9a\u306e\u7d4c\u8def\u306e\u5e72\u6e09\u3084\u95a2\u9023\u3059\u308bATP\u30a2\u30fc\u30bc\u306e\u6d3b\u6027\u5316\u306a\u3069\u3001\u8907\u6570\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3042\u308b\u7814\u7a76\u3067\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304cMI I\/R\u640d\u50b7\u306b\u5bfe\u3057\u3066\u9855\u8457\u306a\u4fdd\u8b77\u52b9\u679c\u3092\u63d0\u4f9b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u306fPI3K\/Akt\/eNOS\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u306b\u3088\u308b\u5fc3\u7b4b\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u6291\u5236\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B73\" aria-expanded=\"false\" aria-haspopup=\"true\">Wang J. \u4ed6\u30012015<\/a>\uff09\u3002\u3055\u3089\u306b\u3001\u5225\u306e\u7814\u7a76\u3067\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3088\u3046\u306b\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u708e\u75c7\u30ab\u30b9\u30b1\u30fc\u30c9\u304b\u3089\u80ba\u3092\u4fdd\u8b77\u3059\u308b\u969b\u306e IL-18 \u304a\u3088\u3073 ICAM-1 \u306e\u767a\u73fe\u3092\u963b\u5bb3\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B79\" aria-expanded=\"false\" aria-haspopup=\"true\">Wang Y. \u4ed6\u30012013<\/a>\uff09\u3002\u3055\u3089\u306b\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u4fdd\u8b77\u52b9\u679c\u306f\u3001\u9178\u7d20\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u306e\u6d88\u53bb\u3068\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u5fc3\u7b4b\u306b\u304a\u3051\u308b ICAM-1 \u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u3092\u6e1b\u5c11\u3055\u305b\u3001Na(+)-K(+)-ATPase\u3001Mg(\u5fc3\u7b4b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e 2+)-ATPase\u3001Ca(2+)-ATPase (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B23\" aria-expanded=\"false\" aria-haspopup=\"true\">Jia \u4ed6\u30012008<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.d.d\" class=\"sec\">\n<h3 id=\"sec-a.l.d.dtitle\">\u6297\u708e\u75c7\u52b9\u679c<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u708e\u75c7\u30d7\u30ed\u30bb\u30b9\u306f\u3001CVD \u304a\u3088\u3073\u305d\u308c\u306b\u95a2\u9023\u3059\u308b\u5408\u4f75\u75c7\u306e\u767a\u75c7\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B58\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30eb\u30d1\u30ec\u30ea\u30a2\u307b\u304b\u30012017<\/a>\uff09\u3002\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306f\u708e\u75c7\u6027\u75be\u60a3\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B57\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ed\u30b9\u30011999 \u5e74<\/a>\uff09\u3002\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3001\u9175\u7d20\u3001\u305d\u306e\u4ed6\u306e\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u306a\u3069\u306e\u591a\u304f\u306e\u751f\u7269\u5b66\u7684\u56e0\u5b50\u304c\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u306e\u5f71\u97ff\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B70\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30a6\u30a9\u30eb\u30b7\u30e5\u30012003 \u5e74<\/a>\uff09\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u51a0\u72b6\u52d5\u8108\u75be\u60a3\u3092\u6cbb\u7642\u3057\u3001\u95a2\u9023\u3059\u308b\u708e\u75c7\u53cd\u5fdc\u3092\u8efd\u6e1b\u3067\u304d\u308b\u3053\u3068\u304c\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u89b3\u5bdf\u3055\u308c\u305f\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u6297\u708e\u75c7\u52b9\u679c\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306b\u3088\u308b\u865a\u8840\u30d7\u30ec\u30b3\u30f3\u30c7\u30a3\u30b7\u30e7\u30cb\u30f3\u30b0\u3068\u865a\u8840\u30d7\u30ec\u30b3\u30f3\u30c7\u30a3\u30b7\u30e7\u30cb\u30f3\u30b0\u5358\u72ec\u3092\u6bd4\u8f03\u3057\u305f\u7814\u7a76\u306b\u3088\u3063\u3066\u5b9f\u8a3c\u3055\u308c\u307e\u3057\u305f\u3002\u4f75\u7528\u7642\u6cd5\u306f\u3001\u30cb\u30e5\u30fc\u30b8\u30fc\u30e9\u30f3\u30c9\u30a6\u30b5\u30ae\u306e\u5fc3\u7b4b I\/R \u4e2d\u306e\u5fc3\u7b4b\u4fdd\u8b77\u3092\u9054\u6210\u3059\u308b\u305f\u3081\u306b\u3001TNF-\u03b1 \u3068 NF-\u03baB \u306e\u767a\u73fe\u3092\u6e1b\u5c11\u3055\u305b\u3001\u708e\u75c7\u306b\u3088\u308b\u50b7\u5bb3\u3092\u8efd\u6e1b\u3059\u308b\u52b9\u679c\u304c\u3088\u308a\u512a\u308c\u3066\u3044\u307e\u3057\u305f (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B99\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8d99\u30012010<\/a>\uff09\u3002\u540c\u69d8\u306b\u3001TNF-\u03b1 \u3068 IL-6 \u306e\u767a\u73fe\u3092\u6e1b\u5c11\u3055\u305b\u3066\u3001\u30e9\u30c3\u30c8\u306e I\/R \u640d\u50b7\u3092\u8efd\u6e1b\u3059\u308b\u53ef\u80fd\u6027\u3082\u3042\u308a\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B15\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30b4\u30f3\u30b0\u3089\u30012013<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.d.e\" class=\"sec\">\n<h3 id=\"sec-a.l.d.etitle\">\u6297\u51dd\u56fa\u4f5c\u7528<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u51dd\u56fa\u7cfb\u3068\u6297\u51dd\u56fa\u7cfb\u304a\u3088\u3073\u7dda\u6eb6\u7cfb\u306f\u52d5\u7684\u306b\u76f8\u4e92\u4f5c\u7528\u3057\u3001\u751f\u7406\u5b66\u7684\u6b62\u8840\u306b\u304a\u3044\u3066\u4e3b\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\u3053\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u5e45\u5e83\u3044\u75be\u60a3\u306b\u5171\u901a\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u53ef\u80fd\u6027\u3082\u3042\u308a\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u3055\u307e\u3056\u307e\u306a\u75be\u60a3\u3001\u7279\u306b\u5fc3\u81d3\u75c5\u3001\u304c\u3093\u3001\u708e\u75c7\u306e\u75c5\u7406\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059(<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B40\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30de\u30eb\u30af\u30b9\u30011982\u5e74<\/a>\uff09\u3002\u30c8\u30ed\u30f3\u30dc\u30e2\u30b8\u30e5\u30ea\u30f3 (TM) \u7523\u751f\u306e\u8a98\u5c0e\u3068\u7d30\u80de\u8868\u9762\u3067\u306e TM \u767a\u73fe\u306e\u4e0b\u65b9\u5236\u5fa1\u3001\u304a\u3088\u3073\u7d30\u80de\u304b\u3089\u306e TM \u653e\u51fa\u306e\u963b\u5bb3\u306b\u3088\u3063\u3066\u793a\u3055\u308c\u308b\u3088\u3046\u306b\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u5185\u76ae\u7d30\u80de\u306e\u7dda\u7dad\u7d20\u6eb6\u89e3\u3068\u6297\u51dd\u56fa\u3092\u30b7\u30df\u30e5\u30ec\u30fc\u30c8\u3067\u304d\u308b\u3068\u3044\u3046\u8a3c\u62e0\u304c\u3042\u308a\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B105\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5468\u3089\u30011992<\/a>\uff09\u3002\u3055\u3089\u306b\u3001\u5225\u306e\u7814\u7a76\u3067\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u62bd\u51fa\u7269\u304c\u51dd\u56fa\u6642\u9593 (CT) \u3068\u30d7\u30ed\u30c8\u30ed\u30f3\u30d3\u30f3\u6642\u9593 (PT) \u3092\u5927\u5e45\u306b\u9045\u3089\u305b\u3001\u8840\u5c0f\u677f\u7b2c III \u56e0\u5b50 (PF3) \u306e\u6d3b\u6027\u3092\u963b\u5bb3\u3057\u3001\u30e6\u30fc\u30b0\u30ed\u30d6\u30ea\u30f3\u6eb6\u89e3\u6642\u9593 (ELT) \u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u6297\u51dd\u56fa\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u7dda\u7dad\u7d20\u6eb6\u89e3\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B80\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ef\u30f3\u4ed6\u30012003<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.d.f\" class=\"sec\">\n<h3 id=\"sec-a.l.d.ftitle\">\u6297\u8840\u6813\u4f5c\u7528<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u75c5\u539f\u6027\u8840\u6813\u306f\u3001\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u3084\u865a\u8840\u6027\u8133\u5352\u4e2d\u306a\u3069\u306e\u6025\u6027\u306e\u81e8\u5e8a\u7684\u30a2\u30c6\u30ed\u30fc\u30e0\u8840\u6813\u6027\u75be\u60a3\u306e\u539f\u56e0\u3068\u306a\u308a\u307e\u3059\u3002\u6d3b\u6027\u5316\u3055\u308c\u305f\u8840\u5c0f\u677f\u306f\u3001\u75c5\u539f\u6027\u8840\u6813\u306e\u5f62\u6210\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u8840\u5c0f\u677f\u6d3b\u6027\u5316\u306e\u30d7\u30ed\u30bb\u30b9\u4e2d\u3001\u30c8\u30ed\u30f3\u30dc\u30ad\u30b5\u30f3 A2 (TxA2)\u3001\u30a2\u30c7\u30ce\u30b7\u30f3\u4e8c\u30ea\u30f3\u9178 (ADP)\u3001\u30c8\u30ed\u30f3\u30d3\u30f3\u306a\u3069\u306e\u7279\u5b9a\u306e\u30a2\u30b4\u30cb\u30b9\u30c8\u306f\u3001\u8840\u5c0f\u677f\u8868\u9762\u306e\u5bfe\u5fdc\u3059\u308b\u53d7\u5bb9\u4f53\u3068\u4f1a\u5408\u3057\u307e\u3059\u3002\u30a2\u30c6\u30ed\u30fc\u30e0\u8840\u6813\u75c7\u306b\u82e6\u3057\u3080\u60a3\u8005\u306f\u3001TxA2\uff08\u30a2\u30b9\u30d4\u30ea\u30f3\uff09\u304a\u3088\u3073ADP\uff08\u30af\u30ed\u30d4\u30c9\u30b0\u30ec\u30eb\u3001\u30c1\u30af\u30ed\u30d4\u30b8\u30f3\u306a\u3069\u306eP2Y12\u963b\u5bb3\u5264\uff09\u8840\u5c0f\u677f\u6d3b\u6027\u5316\u7d4c\u8def\u3092\u6a19\u7684\u3068\u3059\u308b\u7d4c\u53e3\u6297\u8840\u5c0f\u677f\u85ac\u306e\u4f7f\u7528\u304b\u3089\u6069\u6075\u3092\u53d7\u3051\u307e\u3057\u305f\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B11\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30d5\u30a3\u30f3\u30c6\u30eb\u30012012<\/a>\uff09\u3002\u3042\u308b\u8abf\u67fb\u306b\u3088\u308b\u3068\u3001\u00a0<em>\u30a8\u30ea\u30b2\u30ed\u30f3\u30fb\u30d6\u30ec\u30d3\u30b9\u30ab\u30d7\u30b9<\/em>\u00a0\u30d5\u30e9\u30dc\u30f3\u306f\u3001ADP\u3001\u30a2\u30e9\u30ad\u30c9\u30f3\u9178 (AA)\u3001\u8840\u5c0f\u677f\u6d3b\u6027\u5316\u56e0\u5b50 (PAF) \u304c\u8840\u6813\u3092\u5f62\u6210\u3059\u308b\u306e\u3092\u5927\u5e45\u306b\u963b\u5bb3\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B61\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30b7\u30a7\u30f3\u3089\u30012000<\/a>\uff09\u3002\u4e00\u65b9\u3001\u5225\u306e\u7814\u7a76\u3067\u306f\u3001\u30b9\u30af\u30c6\u30e9\u30ea\u30f3\u304c\u30e9\u30c3\u30c8\u306eADP\u8a98\u767a\u6027\u8840\u5c0f\u677f\u51dd\u96c6\u901f\u5ea6\u3092\u7528\u91cf\u4f9d\u5b58\u7684\u306b\u5236\u9650\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u8840\u6813\u75c7\u3068\u8840\u5c0f\u677f\u51dd\u96c6\u3092\u4e88\u9632\u3057\u3001\u8840\u6db2\u30ec\u30aa\u30ed\u30b8\u30fc\u306e\u7279\u6027\u3092\u6539\u5584\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B64\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30bd\u30f3\u30b0\u4ed6\u30012011<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.d.g\" class=\"sec\">\n<h3 id=\"sec-a.l.d.gtitle\">\u5185\u76ae\u4fdd\u8b77\u52b9\u679c<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u8840\u7ba1\u5185\u76ae\u7d30\u80de (VEC) \u306f\u3001\u5185\u5206\u6ccc\u7cfb\u304a\u3088\u3073\u6a19\u7684\u81d3\u5668\u306b\u3068\u3063\u3066\u91cd\u8981\u3067\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B59\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30b5\u30ec\u30b9\u307b\u304b\u30012016<\/a>\uff09\u3002 VEC \u3078\u306e\u640d\u50b7\u306f\u3055\u307e\u3056\u307e\u306a\u8840\u7ba1\u6a5f\u80fd\u4e0d\u5168\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u591a\u304f\u306e\u5834\u5408\u3001\u5185\u76ae\u7d30\u80de\u640d\u50b7\u3001\u9178\u7d20\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u306e\u751f\u6210\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u653e\u51fa\u3092\u4f34\u3044\u307e\u3059\u3002\u3042\u308b\u7814\u7a76\u3067\u306f\u3001Dengzhan Xixin \u6ce8\u5c04 (\u4e3b\u6210\u5206\u306f\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3) \u304c\u708e\u75c7\u53cd\u5fdc\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u5fc3\u81d3\u5fae\u5c0f VEC \u306b\u5bfe\u3059\u308b TNF-\u03b1 \u306e\u640d\u50b7\u3092\u8efd\u6e1b\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B94\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f35\u4ed6\u30012009<\/a>\uff09\u3002\u4e00\u65b9\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001ox-LDL \u8a98\u767a\u306e\u5185\u76ae\u7d30\u80de\u50b7\u5bb3\u306b\u304a\u3044\u3066\u4fdd\u8b77\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u306f\u305d\u306e\u6297\u9178\u5316\u4f5c\u7528\u3068 NF-\u03baB \u6d3b\u6027\u5316\u306e\u963b\u5bb3\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B5\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30c1\u30a7\u30f3\u4ed6\u30012015<\/a>\uff09\u3002\u8840\u7ba1\u5185\u76ae\u5897\u6b96\u56e0\u5b50 (VEGF) \u306f\u3001\u751f\u7406\u5b66\u7684\u304a\u3088\u3073\u75c5\u7406\u5b66\u7684\u8840\u7ba1\u65b0\u751f\u306e\u4e21\u65b9\u306b\u304a\u3044\u3066\u6700\u3082\u5f37\u529b\u306a\u8840\u7ba1\u65b0\u751f\u56e0\u5b50\u3067\u3042\u308a\u3001\u640d\u50b7\u5f8c\u306e\u4fee\u5fa9\u30d7\u30ed\u30bb\u30b9\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u30b9\u30c6\u30c3\u30d7\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u540c\u69d8\u306b\u3001\u5225\u306e\u7814\u7a76\u3067\u306f\u3001\u30b9\u30af\u30c6\u30e9\u30ea\u30f3\u304c\u865a\u8840\u518d\u704c\u6d41\u50b7\u5bb3\u5f8c\u306e VEC \u306b\u5bfe\u3057\u3066\u4fdd\u8b77\u52b9\u679c\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f VEGF \u306e\u65e9\u671f\u5897\u52a0\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B31\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ea\u30f3\u4ed6\u30012011<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.d.h\" class=\"sec\">\n<h3 id=\"sec-a.l.d.htitle\">\u5fc3\u7b4b\u4fdd\u8b77\u52b9\u679c<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u5fc3\u81d3\u624b\u8853\u3001\u865a\u8840\u518d\u704c\u6d41\u50b7\u5bb3\u3001\u7cd6\u5c3f\u75c5\u6027\u50b7\u5bb3\u3001\u4f4e\u9178\u7d20\u50b7\u5bb3\u306a\u3069\u306e\u75c5\u7406\u5b66\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u5fc3\u7b4b\u7d30\u80de\u304c\u50b7\u5bb3\u3055\u308c\u308b\u3068\u3001\u75c5\u7406\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u306f\u6700\u521d\u306e\u7d30\u80de\u6d6e\u816b\u3001\u5909\u6027\u3001\u58ca\u6b7b\u304b\u3089\u5fc3\u80a5\u5927\u304a\u3088\u3073\u5fc3\u7b4b\u7dda\u7dad\u75c7\u306b\u9032\u5c55\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u6f5c\u5728\u7684\u306a\u5fc3\u7b4b\u4fdd\u8b77\u52b9\u679c\u3068\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u3059\u308b\u7814\u7a76\u304c\u3044\u304f\u3064\u304b\u3042\u308a\u307e\u3059\u3002\u3042\u308b\u7814\u7a76\u3067\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304cLDH\u6f0f\u51fa\u3001\u7d30\u80de\u5185\u904a\u96e2Ca\u3092\u5927\u5e45\u306b\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u5fc3\u7b4b\u4fdd\u8b77\u306b\u6709\u5229\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<sup>2+<\/sup>\u00a0\u4f4e\u9178\u7d20\u72b6\u614b\u306b\u3055\u3089\u3055\u308c\u305f\u5fc3\u7b4b\u7d30\u80de\u306e\u30ec\u30d9\u30eb\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u304a\u3088\u3073\u58ca\u6b7b (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B28\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ea\u30fc\u3089\u30012004<\/a>\uff09\u3002\u7cd6\u5c3f\u75c5\u6027\u640d\u50b7\u306e\u5834\u5408\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc C (PKC) \u3068\u30db\u30b9\u30db\u30e9\u30f3\u30d0\u30f3 (PLB) \u306e\u767a\u73fe\u3092\u6e1b\u5c11\u3055\u305b\u3001\u30d7\u30ed\u30c6\u30a4\u30f3\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc\u963b\u5bb3\u5264-1 (PPI-1) \u306e\u767a\u73fe\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u7cd6\u5c3f\u75c5\u6027\u5fc3\u7b4b\u75c7\u306b\u5bfe\u3059\u308b\u4fdd\u8b77\u52b9\u679c\u304c\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 Ca(2+)-ATPase (SERCA-2)\u3001\u304a\u3088\u3073\u30ea\u30a2\u30ce\u30b8\u30f3\u53d7\u5bb9\u4f53 (RyR) (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B77\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ef\u30f3\u4ed6\u30012010<\/a>\uff09\u3002\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3 II (Ang II) \u306b\u3088\u3063\u3066\u8a98\u767a\u3055\u308c\u308b\u5fc3\u80a5\u5927\u306e\u72b6\u614b\u306b\u304a\u3044\u3066\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u5fc3\u7b4b\u7d30\u80de\u306e PKC-\u03b1 \u4f9d\u5b58\u6027 ERK1\/2 \u304a\u3088\u3073 PI3K\/AKT \u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u7834\u58ca\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u5fc3\u80a5\u5927\u306b\u5bfe\u3059\u308b\u4fdd\u8b77\u80fd\u529b\u3092\u4f9d\u7136\u3068\u3057\u3066\u6301\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u5b9f\u8a3c\u3055\u308c\u307e\u3057\u305f\u3002\u00a0<em>\u8a66\u9a13\u7ba1\u5185\u3067<\/em>\u00a0\u3068\u30de\u30a6\u30b9\u00a0<em>\u751f\u4f53\u5185<\/em>\u00a0(<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B86\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30e4\u30f3\u307b\u304b\u30012010<\/a>\uff09\u3002\u5225\u306e\u7814\u7a76\u3067\u306f\u3001\u30b9\u30af\u30c6\u30e9\u30ea\u30f3\u304c\u5fc3\u81d3\u5185\u76ae\u9593\u8449\u8ee2\u63db\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30a4\u30bd\u30d7\u30ec\u30ca\u30ea\u30f3\u8a98\u767a\u6027\u5fc3\u7b4b\u7dda\u7dad\u75c7\u3092\u4e88\u9632\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3082\u793a\u5506\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u306fNotch\u7d4c\u8def\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B104\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5468\u307b\u304b\u30012014<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.d.i\" class=\"sec\">\n<h3 id=\"sec-a.l.d.ititle\">\u5e73\u6ed1\u7b4b\u7d30\u80de\u306e\u904a\u8d70\u3068\u5897\u6b96\u306e\u6e1b\u5c11<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u8840\u7ba1\u5e73\u6ed1\u7b4b\u7d30\u80de (VSMC) \u306e\u904a\u8d70\u3068\u5897\u6b96\u306f\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306e\u767a\u75c7\u306b\u304a\u3051\u308b\u4e3b\u8981\u306a\u75c5\u614b\u751f\u7406\u5b66\u7684\u30b9\u30c6\u30c3\u30d7\u3067\u3059\u3002\u3055\u3089\u306b\u3001VSMC \u5897\u6b96\u306e\u8abf\u7bc0\u306b\u306f\u8840\u7ba1\u75be\u60a3\u306e\u6cbb\u7642\u52b9\u679c\u304c\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B56\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ed\u30b9\u30011993\u5e74<\/a>\uff09\u3002\u30c8\u30ed\u30f3\u30d3\u30f3\u306f VSMC \u306e\u5897\u6b96\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30c8\u30ed\u30f3\u30d3\u30f3\u53d7\u5bb9\u4f53\u306f\u3001\u8840\u5c0f\u677f\u3001\u5185\u76ae\u7d30\u80de\u3001VSMC \u306a\u3069\u3001\u30c8\u30ed\u30f3\u30d3\u30f3\u306b\u5fdc\u7b54\u3059\u308b\u3059\u3079\u3066\u306e\u7d30\u80de\u578b\u306b\u5b58\u5728\u3057\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u30c8\u30ed\u30f3\u30d3\u30f3\u53d7\u5bb9\u4f53\u30a2\u30f3\u30bf\u30b4\u30cb\u30b9\u30c8\u306f\u3001\u7d30\u80de\u5897\u6b96\u306e\u7279\u7570\u7684\u963b\u5bb3\u306b\u3088\u3063\u3066\u4fa1\u5024\u304c\u3042\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u6cbb\u7642\u85ac\u3068\u3057\u3066\u4f7f\u7528\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B48\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30d1\u30ab\u30e9\u3089\u30012001<\/a>\uff09\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u30e9\u30c3\u30c8\u5927\u52d5\u8108\u5e73\u6ed1\u7b4b\u7d30\u80de\u306e\u5897\u6b96\u3092\u5927\u5e45\u306b\u963b\u5bb3\u3057\u3066\u30c8\u30ed\u30f3\u30d3\u30f3\u3092\u8a98\u5c0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u7814\u7a76\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u8003\u3048\u3089\u308c\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001\u30c8\u30ed\u30f3\u30d3\u30f3\u53d7\u5bb9\u4f53\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u30d6\u30ed\u30c3\u30af\u3059\u308b\u3053\u3068\u3067\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B22\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30db\u30a6\u4ed6\u30012009<\/a>\uff09\u3002\u3055\u3089\u306b\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u660e\u3089\u304b\u306b VSMC \u306e\u5897\u6b96\u3092\u963b\u5bb3\u3057\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u3092\u4e88\u9632\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u90e8\u306f VSMC \u306e NF-\u03baB \u6d3b\u6027\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u5b9f\u73fe\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B49\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30d1\u30f3\u4ed6\u30012004<\/a>\uff09\u3002\u3055\u3089\u306b\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001ERK1\/2 MAPK \u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u3001\u9ad8\u30b0\u30eb\u30b3\u30fc\u30b9\u8a98\u5c0e\u6027\u306e VSMC \u306e\u5897\u6b96\u3068\u79fb\u52d5\u3092\u6539\u5584\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B21\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f7c\u3089\u30012012<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.d.j\" class=\"sec\">\n<h3 id=\"sec-a.l.d.jtitle\">\u6297\u5fc3\u81d3\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u52b9\u679c<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u5fc3\u5ba4\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u306f\u3001\u75c5\u7406\u5b66\u7684\u4fee\u5fa9\u3001\u5fc3\u5ba4\u4ee3\u511f\u3001\u304a\u3088\u3073\u5fc3\u7b4b\u640d\u50b7\u306b\u95a2\u9023\u3057\u305f\u4e00\u9023\u306e\u30b5\u30a4\u30ba\u3001\u5f62\u72b6\u3001\u58c1\u539a\u3001\u7d44\u7e54\u69cb\u9020\u306a\u3069\u306e\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u306e\u5909\u5316\u3092\u4f34\u3046\u4e8c\u6b21\u7684\u306a\u75c5\u614b\u751f\u7406\u5b66\u7684\u53cd\u5fdc\u306e\u30d7\u30ed\u30bb\u30b9\u3067\u3059\u3002\u3042\u308b\u7814\u7a76\u3067\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u5fc3\u7b4b\u306e\u53ce\u7e2e\u6a5f\u80fd\u3068\u62e1\u5f35\u6a5f\u80fd\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u5fc3\u4e0d\u5168\u52d5\u7269\u306e\u5fc3\u5ba4\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3092\u8abf\u7bc0\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B30\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ea\u30fc\u30012011<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.d.k\" class=\"sec\">\n<h3 id=\"sec-a.l.d.ktitle\">\u6297\u4e0d\u6574\u8108\u52b9\u679c<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001\u30a6\u30b5\u30ae\u306e\u5fc3\u81d3\u304a\u3088\u3073\u30e9\u30c3\u30c8\u306e\u5fc3\u5ba4\u7b4b\u7d30\u80de\u306b\u5bfe\u3059\u308b\u7279\u5b9a\u306e\u7a2e\u985e\u306e\u7279\u7570\u7684\u306a\u6297\u4e0d\u6574\u8108\u52b9\u679c\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u52b9\u679c\u306e\u80cc\u5f8c\u306b\u3042\u308b\u6839\u672c\u7684\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u4f9d\u7136\u3068\u3057\u3066\u4e0d\u660e\u3067\u3042\u308a\u3001\u307e\u3060\u7814\u7a76\u4e2d\u3067\u3059\u3002\u3042\u308b\u7814\u7a76\u3067\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u7d4c\u58c1\u518d\u5206\u6975\u5206\u6563\uff08TDR\uff09\u3092\u6e1b\u5c11\u3055\u305b\u3001\u8131\u5206\u6975\u5f8c\u65e9\u671f\uff08EAD\uff09\u3068\u30c8\u30eb\u30b5\u30fc\u30c9\u30fb\u30c9\u30fb\u30dd\u30ef\u30f3\u30c8\uff08Tdp\uff09\u306e\u767a\u751f\u7387\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u80a5\u5927\u3057\u305f\u30a6\u30b5\u30ae\u306e\u5fc3\u81d3\u306b\u304a\u3051\u308b\u5fc3\u5ba4\u6027\u4e0d\u6574\u8108\u306e\u767a\u751f\u7387\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B1\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30dc\u30fc\u4ed6\u30012011<\/a>\uff09\u3002\u5fc3\u81d3\u306e\u96fb\u6c17\u7684\u6d3b\u52d5\u306f\u3001\u751f\u7406\u5b66\u7684\u6a5f\u80fd\u306b\u95a2\u3057\u3066\u5fc3\u81d3\u7d30\u80de\u306e\u819c\u4e0a\u306e\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u306b\u4f9d\u5b58\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6b21\u306b\u3001\u5fc3\u5ba4\u7b4b\u7d30\u80de\u306e\u30ab\u30ea\u30a6\u30e0\u3068\u30ca\u30c8\u30ea\u30a6\u30e0\u306e\u6d41\u308c\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u3044\u3046\u61f8\u5ff5\u304c\u751f\u3058\u3066\u3044\u307e\u3059\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u30ab\u30ea\u30a6\u30e0\u96fb\u6d41\u3092\u963b\u5bb3\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u89b3\u5bdf\u3055\u308c\u3066\u3044\u307e\u3059\uff08I<sub>\u306b<\/sub>) \u6fc3\u5ea6\u3068\u96fb\u5727\u306b\u4f9d\u5b58\u3057\u3066 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B6\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30c7\u30f3\u4ed6\u30012008<\/a>\uff09 \u305d\u3057\u3066\u79c1<sub>\u30ca<\/sub>\u00a0\u6fc3\u5ea6\u306b\u4f9d\u5b58\u3057\u305f\u30c1\u30e3\u30cd\u30eb\u96fb\u6d41 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B65\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30bf\u30f3\u4ed6\u30012009<\/a>\uff09\u3001\u3053\u308c\u306f\u6297\u4e0d\u6574\u8108\u52b9\u679c\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.d.l\" class=\"sec\">\n<h3 id=\"sec-a.l.d.ltitle\">\u8102\u8cea\u4f4e\u4e0b\u52b9\u679c<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u8102\u8cea\u4f4e\u4e0b\u306fCVD\u306e\u65e5\u5e38\u7684\u306a\u6cbb\u7642\u6cd5\u3067\u3059\u3002\u3044\u304f\u3064\u304b\u306e\u81e8\u5e8a\u7814\u7a76\u3067\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u8840\u4e2d\u8102\u8cea\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u52d5\u7269\u5b9f\u9a13\u3067\u306f\u7570\u306a\u308b\u7d50\u679c\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002\u3042\u308b\u7814\u7a76\u3067\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u7cd6\u5c3f\u75c5\u30e9\u30c3\u30c8\u306e\u8840\u4e2d\u8102\u8cea\u30ec\u30d9\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B81\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30a6\u30a7\u30a4\u3089\u30012010<\/a>\uff09\u3002\u5225\u306e\u7814\u7a76\u3067\u306f\u3001\u5185\u819c\u904e\u5f62\u6210\u3068\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u306e\u9032\u884c\u3092\u963b\u5bb3\u3059\u308b\u53ef\u80fd\u6027\u306f\u3042\u308b\u304c\u3001\u8840\u6e05\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B37\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30eb\u30fc\u3068\u30ea\u30e5\u30fc\u30012009<\/a>\uff09\u3002\u3055\u3089\u306b\u3001\u305d\u306e\u8102\u8cea\u4f4e\u4e0b\u52b9\u679c\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u8aac\u660e\u3057\u305f\u7814\u7a76\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.d.m\" class=\"sec sec-last\">\n<h3 id=\"sec-a.l.d.mtitle\">\u52c3\u8d77\u4e0d\u5168\u306e\u6539\u5584<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u52c3\u8d77\u53cd\u5fdc\u306e\u969c\u5bb3\u306f\u3001\u672c\u614b\u6027\u9ad8\u8840\u5727\u75c7\u306e\u6f5c\u5728\u7684\u306a\u5408\u4f75\u75c7\u306e 1 \u3064\u3067\u3059\u3002\u52d5\u8108\u6027\u9ad8\u8840\u5727\u75c7\u306e\u7ba1\u7406\u306b\u95a2\u3059\u308b 2013 \u5e74\u306e ESH\/ESC \u30ac\u30a4\u30c9\u30e9\u30a4\u30f3 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B9\" aria-expanded=\"false\" aria-haspopup=\"true\">\u52d5\u8108\u6027\u9ad8\u8840\u5727\u75c7\u7ba1\u7406\u306e\u305f\u3081\u306e ESH\/ESC \u30bf\u30b9\u30af\u30d5\u30a9\u30fc\u30b9\u30012013 \u5e74<\/a>\uff09\u3001\u52c3\u8d77\u4e0d\u5168\u306f\u72ec\u7acb\u3057\u305f\u5fc3\u8840\u7ba1\u5371\u967a\u56e0\u5b50\u3067\u3042\u308a\u3001\u81e8\u5e8a\u81d3\u5668\u640d\u50b7\u306e\u65e9\u671f\u8a3a\u65ad\u6307\u6a19\u3067\u3042\u308b\u3068\u8003\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u9ad8\u8840\u5727\u8a98\u767a\u6027\u306e\u52c3\u8d77\u4e0d\u5168\u3092\u9006\u8ee2\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u3092\u8abf\u3079\u308b\u3053\u3068\u306b\u7126\u70b9\u304c\u5f53\u3066\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u81ea\u7136\u9ad8\u8840\u5727\u30e9\u30c3\u30c8 (SHR) \u306e\u52c3\u8d77\u53cd\u5fdc\u969c\u5bb3\u306f\u3001RhoA\/Rho \u30ad\u30ca\u30fc\u30bc\u306b\u3088\u308b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u5897\u52a0\u3068\u4e00\u9178\u5316\u7a92\u7d20 (NO) \u306b\u3088\u308b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u6e1b\u5c11\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u7d50\u8ad6\u4ed8\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3042\u308b\u7814\u7a76\u3067\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c RhoA\/Rho \u30ad\u30ca\u30fc\u30bc\u7d4c\u8def\u3092\u4e0b\u65b9\u5236\u5fa1\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u52c3\u8d77\u6a5f\u80fd\u3092\u6539\u5584\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B29\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ea\u30fc\u3089\u30012014<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<div id=\"sec-a.l.e\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"sec-a.l.etitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u81e8\u5e8aCVD\u6cbb\u7642\u306e\u305f\u3081\u306e\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/h2>\n<p>&nbsp;<\/p>\n<p class=\"p p-first\">\u5fc3\u8840\u7ba1\u75be\u60a3\u306f\u4f9d\u7136\u3068\u3057\u3066\u4e16\u754c\u4e2d\u3067\u4e3b\u306a\u6b7b\u56e0\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002 2008 \u5e74\u306e\u4e16\u754c\u306e\u6b7b\u4ea1\u8005\u6570 5,700 \u4e07\u4eba\u306e\u3046\u3061\u30011,730 \u4e07\u4eba\u4ee5\u4e0a (30%) \u304c CVD \u306b\u3088\u308b\u3082\u306e\u3067\u3057\u305f\u3002\u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u3088\u308b\u6b7b\u4ea1\u7387\u306f\u3001\u904e\u53bb 20 \u5e74\u9593\u306b\u591a\u304f\u306e\u9ad8\u6240\u5f97\u56fd\u3067\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u304c\u3001\u4f4e\u6240\u5f97\u56fd\u304a\u3088\u3073\u4e2d\u6240\u5f97\u56fd\u3067\u306f\u3001\u56fd\u6c11\u5168\u4f53\u306b\u308f\u305f\u308b\u4e00\u6b21\u4e88\u9632\u3068\u500b\u5225\u306e\u533b\u7642\u4ecb\u5165\u304c\u4e0d\u8db3\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u6025\u901f\u306b\u5897\u52a0\u3057\u3066\u3044\u307e\u3059\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B43\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30e1\u30f3\u30c7\u30a3\u30b9\u4ed6\u30012011<\/a>\uff09\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001\u8840\u7ba1\u62e1\u5f35\u3001\u5fc3\u7b4b\u4fdd\u8b77\u3001\u6297\u4e0d\u6574\u8108\u3001\u52d5\u8108\u8840\u5727\u4f4e\u4e0b\u306a\u3069\u306b\u52b9\u679c\u304c\u3042\u308b\u305f\u3081\u3001\u4e2d\u56fd\u3067\u306fCVD\u4e88\u9632\u306b\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u591a\u304f\u306e\u7814\u7a76\u304c\u3053\u308c\u3089\u306e\u597d\u307e\u3057\u3044\u52b9\u679c\u3092\u88cf\u4ed8\u3051\u308b\u8a3c\u62e0\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u3044\u304f\u3064\u304b\u306e\u7814\u7a76\u3067\u306f\u3001CVD \u3067\u767a\u751f\u3059\u308b\u76ae\u819a\u767a\u75b9\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u30b7\u30e7\u30c3\u30af\u3001\u5fc3\u623f\u7d30\u52d5 (AF)\u3001\u4e0b\u75e2\u306a\u3069\u306e\u526f\u4f5c\u7528\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B35\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ea\u30e5\u30fc\u3068\u30d0\u30a4\u30012012<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B97\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f35\u4ed6\u30012016<\/a>\uff09\u3002\u3053\u306e\u8ad6\u6587\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3[\u51a0\u72b6\u52d5\u8108\u6027\u5fc3\u75be\u60a3(CHD)\u3001MI\u3001\u9ad8\u8840\u5727\u3001\u4e0d\u6574\u8108\u306a\u3069]\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u52b9\u679c\u3092\u5831\u544a\u3057\u305f\u79d1\u5b66\u6587\u732e\u3092\u6279\u5224\u7684\u306b\u691c\u8a0e\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30ec\u30d3\u30e5\u30fc\u3092\u5b9f\u65bd\u3059\u308b\u305f\u3081\u306e\u65b9\u6cd5\u8ad6\u306b\u57fa\u3065\u3044\u3066\u3001\u3053\u306e\u30ec\u30d3\u30e5\u30fc\u306b\u306f 19 \u4ef6\u306e\u8a66\u9a13\u304c\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u4e2d\u306b\u306f CHD \u306b\u95a2\u3059\u308b 2 \u4ef6\u306e\u8a66\u9a13\u3001MI \u306b\u95a2\u3059\u308b 3 \u4ef6\u306e\u8a66\u9a13\u3001\u9ad8\u8840\u5727\u306b\u95a2\u3059\u308b 2 \u4ef6\u306e\u8a66\u9a13\u3001\u4e0d\u6574\u8108\u306b\u95a2\u3059\u308b 1 \u4ef6\u306e\u8a66\u9a13\u3001\u9ad8\u8102\u8840\u75c7\u306b\u95a2\u3059\u308b 3 \u4ef6\u306e\u8a66\u9a13\u3001\u30a6\u30a4\u30eb\u30b9\u306b\u95a2\u3059\u308b 2 \u4ef6\u306e\u8a66\u9a13\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u5fc3\u7b4b\u708e\uff08VMC\uff09\u3001\u6162\u6027\u5fc3\u4e0d\u5168\uff08CHF\uff09\u306b\u95a2\u3059\u308b3\u4ef6\u306e\u8a66\u9a13\u3001\u80ba\u5fc3\u75be\u60a3\uff08PHD\uff09\u306b\u95a2\u3059\u308b3\u4ef6\u306e\u8a66\u9a13\uff08\u56f3\u306b\u793a\u3059\uff09\u00a0<strong>\u30c6\u30fc\u30d6\u30eb\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/table\/T2\/\" target=\"table\" rel=\"noopener\">\u200b<span class=\"figpopup-sensitive-area\">\u88682<\/span>2<\/a><\/strong>).<\/p>\n<p>&nbsp;<\/p>\n<div id=\"sec-a.l.e.c\" class=\"sec\">\n<h3 id=\"sec-a.l.e.ctitle\">\u51a0\u72b6\u52d5\u8108\u6027\u5fc3\u81d3\u75c5<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first\">\u51a0\u72b6\u52d5\u8108\u6027\u5fc3\u75be\u60a3\u306f\u6700\u3082\u4e00\u822c\u7684\u306a\u30bf\u30a4\u30d7\u306e CVD \u3067\u3042\u308a\u3001\u81f4\u547d\u7684\u306a\u75c5\u6c17\u306e 1 \u3064\u3067\u3059\u3002\u6700\u65b0\u306e\u30c7\u30fc\u30bf\u306b\u3088\u308b\u3068\u3001CHD \u306b\u3088\u308a 814 \u4e07\u4eba\u304c\u6b7b\u4ea1\u3057\u30012013 \u5e74\u306e\u5168\u4e16\u754c\u306e\u6b7b\u4ea1\u8005\u6570\u306e 16.8% \u3092\u5360\u3081\u307e\u3057\u305f (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B14\" aria-expanded=\"false\" aria-haspopup=\"true\">GBD 2013 \u306e\u6b7b\u4ea1\u7387\u3068\u6b7b\u56e0\u306e\u5354\u529b\u8005\u30012015 \u5e74<\/a>\uff09\u3002\u73fe\u5728\u3001\u904b\u52d5\u3001\u5065\u5eb7\u7684\u306a\u98df\u4e8b\u3001\u9ad8\u8840\u5727\u306e\u6cbb\u7642\u3001\u30a2\u30b9\u30d4\u30ea\u30f3\u3001\u30cb\u30c8\u30ed\u30b0\u30ea\u30bb\u30ea\u30f3\u3001\u30d9\u30fc\u30bf\u906e\u65ad\u85ac\u3001\u30b9\u30bf\u30c1\u30f3\u306a\u3069\u306e\u6297\u8840\u5c0f\u677f\u85ac\u3092\u542b\u3080\u85ac\u7269\u7642\u6cd5\u306a\u3069\u306e\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u5909\u66f4\u306b\u3088\u308a\u3001CHD\u306e\u7f79\u60a3\u7387\u306f\u3042\u308b\u7a0b\u5ea6\u6e1b\u5c11\u3057\u3066\u3044\u307e\u3059\u3002 \u3002\u305f\u3060\u3057\u3001\u3053\u308c\u3089\u306e\u85ac\u306b\u306f\u907f\u3051\u3089\u308c\u306a\u3044\u526f\u4f5c\u7528\u3082\u3042\u308a\u307e\u3059\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001\u4e2d\u56fd\u3067\u6570\u5341\u5e74\u306b\u308f\u305f\u308a\u3001CHD\u306e\u4e88\u9632\u3068\u6cbb\u7642\u306e\u305f\u3081\u306b\u5f93\u6765\u306e\u85ac\u3068\u7d44\u307f\u5408\u308f\u305b\u3066\u4f7f\u7528\u3055\u308c\u3066\u304d\u305f\u88dc\u5b8c\u85ac\u3067\u3059\u3002\u305d\u308c\u306f\u591a\u304f\u306e\u5229\u70b9\u3092\u3082\u305f\u3089\u3057\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u5f93\u6765\u306e\u5358\u72ec\u6cbb\u7642\u3068\u6bd4\u8f03\u3057\u3066\u6cbb\u7642\u52b9\u679c\u304c\u5411\u4e0a\u3057\u3001\u526f\u4f5c\u7528\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u306e\u3042\u308b\u8907\u6570\u306e\u85ac\u5264\u306e\u6295\u4e0e\u91cf\u3092\u6e1b\u3089\u3059\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B71\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ef\u30f3 C. \u4ed6\u30012015<\/a>\uff09\u3002 CHD\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u52b9\u679c\u3092\u8abf\u67fb\u3059\u308b\u305f\u3081\u306b\u3001\u591a\u6570\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u5bfe\u7167\u8a66\u9a13\u304c\u5b9f\u65bd\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n<p class=\"p p-last\">\u3042\u308b\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3067\u306f\u3001\u5b89\u5b9a\u72ed\u5fc3\u75c7\u306e\u60a3\u800550\u4eba\u30922\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\uff0840mg\/250ml\u306e0.9%\u5869\u5316\u30ca\u30c8\u30ea\u30a6\u30e0\u3001\u70b9\u6ef4\u3001\u6bce\u65e5\uff09\u3068\u6a19\u6e96\u85ac\uff08<em>n<\/em>\u00a0= 25) \u307e\u305f\u306f\u6a19\u6e96\u85ac\u5358\u72ec (<em>n<\/em>\u00a0= 25) 14 \u65e5\u9593\u3002\u305d\u306e\u7d50\u679c\u3001\u72ed\u5fc3\u75c7\u306e\u75c7\u72b6\u3001\u5fc3\u96fb\u56f3\u306b\u304a\u3051\u308bST-T\u306e\u5909\u5316\u3001\u52d5\u7684\u5fc3\u96fb\u56f3\u306b\u304a\u3051\u308bST-T\u306e\u5909\u5316\u6642\u9593\u306f\u3001\u5bfe\u7167\u7fa4\u3088\u308a\u3082\u8a66\u9a13\u7fa4\u306e\u65b9\u304c\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u3055\u3089\u306b\u3001\u30c6\u30b9\u30c8\u30b0\u30eb\u30fc\u30d7\u306e\u5168\u8840\u7c98\u5ea6\uff08WBV\uff09\u3001\u8840\u6f3f\u7c98\u5ea6\uff08PV\uff09\u3001\u30d5\u30a3\u30d6\u30ea\u30ce\u30fc\u30b2\u30f3\uff08FIB\uff09\u3001\u8840\u6e05\u8102\u8cea\u306a\u3069\u306e\u8840\u6db2\u30ec\u30aa\u30ed\u30b8\u30fc\u306e\u6539\u5584\u306f\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u30b0\u30eb\u30fc\u30d7\u3088\u308a\u3082\u9855\u8457\u3067\u3057\u305f\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B95\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f35\u3068\u5f35\u30012012<\/a>\uff09\u3002\u540c\u69d8\u306b\u3001\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u60a3\u8005\u306b\u304a\u3051\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u6709\u52b9\u6027\u3092\u30c6\u30b9\u30c8\u3059\u308b\u305f\u3081\u306b\u5225\u306e RCT \u304c\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002\u60a3\u8005\u306f\u3001\u5f93\u6765\u306e\u897f\u6d0b\u85ac\u306b\u52a0\u3048\u3066\u6bce\u65e5 20 ml \u306e\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u3092\u6295\u4e0e\u3055\u308c\u308b\u3088\u3046\u7121\u4f5c\u70ba\u306b\u5272\u308a\u5f53\u3066\u3089\u308c\u307e\u3057\u305f\u3002<em>n<\/em>\u00a0= 53) \u307e\u305f\u306f\u5f93\u6765\u306e\u897f\u6d0b\u533b\u5b66\u5358\u72ec (<em>n<\/em>\u00a0= 51) 2 \u9031\u9593\u3002\u7d50\u679c\u306f\u3001\u8a66\u9a13\u30b0\u30eb\u30fc\u30d7\u306e\u4e8c\u785d\u9178\u30a4\u30bd\u30bd\u30eb\u30d3\u30c9\u306e\u7528\u91cf\u304c\u5bfe\u7167\u30b0\u30eb\u30fc\u30d7\u3088\u308a\u3082\u5c11\u306a\u304f\u3001\u5fc3\u96fb\u56f3\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u52b9\u679c\u304c\u8a66\u9a13\u30b0\u30eb\u30fc\u30d7\u306e\u65b9\u304c\u512a\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u8a66\u9a13\u7fa4\u306e\u5168\u8840\u9ad8\u7c98\u5ea6\uff08WBHV\uff09\u3001PV\u3001\u8d64\u8840\u7403\u51dd\u96c6\u6307\u6570\u3001FIB\u3001\u304a\u3088\u3073hs-CRP\u3082\u5bfe\u7167\u7fa4\u3088\u308a\u3082\u4f4e\u304b\u3063\u305f\u3002\u305d\u308c\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u7814\u7a76\u8005\u3089\u306f 2 \u3064\u306e\u30b0\u30eb\u30fc\u30d7\u9593\u306e\u5168\u8840\u4f4e\u305b\u3093\u65ad\u7c98\u5ea6\u304a\u3088\u3073\u8d64\u8840\u7403\u525b\u6027\u6307\u6570\u306b\u6709\u610f\u306a\u5dee\u3092\u767a\u898b\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u5bfe\u7167\u7fa4\u3067 4 \u4ef6\u306e\u5410\u304d\u6c17\u3068 1 \u4ef6\u306e\u52d5\u60b8\u304c\u5831\u544a\u3055\u308c\u3001\u8a66\u9a13\u7fa4\u3067\u306f 3 \u4ef6\u306e\u5410\u304d\u6c17\u3068 2 \u4ef6\u306e\u8179\u90e8\u81a8\u6e80\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B60\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30b7\u30a7\u30f3\u3089\u30012014<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.e.d\" class=\"sec\">\n<h3 id=\"sec-a.l.e.dtitle\">\u5fc3\u7b4b\u6897\u585e\uff08MI\uff09<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u6025\u6027\u5fc3\u7b4b\u6897\u585e\uff08AMI\uff09\u3068\u3057\u3066\u3082\u77e5\u3089\u308c\u308bMI\u306f\u3001\u7834\u88c2\u3057\u305f\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u306e\u8840\u6813\u306b\u3088\u308b\u5fc3\u81d3\u3078\u306e\u8840\u6d41\u306e\u906e\u65ad\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u5fc3\u81d3\u767a\u4f5c\u3067\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B43\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30e1\u30f3\u30c7\u30a3\u30b9\u4ed6\u30012011<\/a>\uff09\u3002\u3042\u308b\u7814\u7a76\u3067\u306f\u30011990 \u5e74\u304b\u3089 2010 \u5e74\u306e\u9593\u306b\u4e16\u754c\u7684\u306b MI \u306e\u767a\u751f\u7387\u304c\u6e1b\u5c11\u3057\u305f\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B14\" aria-expanded=\"false\" aria-haspopup=\"true\">GBD 2013 \u306e\u6b7b\u4ea1\u7387\u3068\u6b7b\u56e0\u306e\u5354\u529b\u8005\u30012015 \u5e74<\/a>\uff09\u3002\u5fc3\u7b4b\u6897\u585e\u306e\u7f79\u60a3\u7387\u3068\u6b7b\u4ea1\u7387\u306f\u3001\u65e9\u671f\u304b\u3064\u52b9\u679c\u7684\u306a\u4e88\u9632\u63aa\u7f6e\u3068\u4ecb\u5165\u306b\u3088\u3063\u3066\u5927\u5e45\u306b\u5236\u5fa1\u3055\u308c\u3066\u304d\u305f\u304c\u3001\u5fc3\u7b4b\u6897\u585e\u60a3\u8005\u306e\u4e8c\u6b21\u4e88\u9632\u3068\u30ea\u30cf\u30d3\u30ea\u30c6\u30fc\u30b7\u30e7\u30f3\u306b\u306f\u4f9d\u7136\u3068\u3057\u3066\u3044\u304f\u3064\u304b\u306e\u554f\u984c\u304c\u3042\u308b\u3002\u4e2d\u56fd\u533b\u5b66\uff08CM\uff09\u306f\u3001\u751f\u6d3b\u306e\u8cea\uff08QOL\uff09\u306e\u5411\u4e0a\u3084\u6709\u5bb3\u4e8b\u8c61\u306e\u767a\u751f\u7387\u306e\u6e1b\u5c11\u306a\u3069\u3001\u3053\u308c\u3089\u306e\u5074\u9762\u3067\u3044\u304f\u3064\u304b\u306e\u5229\u70b9\u3092\u793a\u3057\u3066\u3044\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B85\" aria-expanded=\"false\" aria-haspopup=\"true\">Xu-Feng \u4ed6\u30012010<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B7\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30c7\u30e5\u30a2\u30f3\u4ed6\u30012012<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B98\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f35 YH\u30012014<\/a>\uff09\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u3092\u7528\u3044\u305f\u3044\u304f\u3064\u304b\u306e\u81e8\u5e8a\u7814\u7a76\u3067\u306f\u3001MI\u306b\u5bfe\u3059\u308b\u305d\u306e\u52b9\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5bfe\u7167\u81e8\u5e8a\u8a66\u9a13\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3 (60 mg\/\u65e5) \u3068\u30eb\u30fc\u30c1\u30f3\u6cbb\u7642 (<em>n<\/em>\u00a0= 25) \u307e\u305f\u306f\u65e5\u5e38\u7684\u306a\u6cbb\u7642\u306e\u307f (<em>n<\/em>\u00a0= 20) 10 \u65e5\u9593\u3002\u5de6\u5ba4\u99c6\u51fa\u7387\uff08LVEF\uff09\u3001\u672b\u68a2\u8840\u7ba1\u62b5\u6297\u3001\u72ed\u5fc3\u75c7\u5f8c\u767a\u75c7\u7387\u306e\u7d50\u679c\u306f\u3001\u5bfe\u7167\u7fa4\u306e\u60a3\u8005\u3068\u6bd4\u8f03\u3057\u3066\u4f75\u7528\u7fa4\u306e\u60a3\u8005\u3067\u6709\u610f\u306b\u7570\u306a\u3063\u3066\u3044\u307e\u3057\u305f\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B18\" aria-expanded=\"false\" aria-haspopup=\"true\">Gu TB \u4ed6\u30012002<\/a>\uff09\u3002\u540c\u69d8\u306b\u3001\u7d4c\u76ae\u7684\u51a0\u52d5\u8108\u30a4\u30f3\u30bf\u30fc\u30d9\u30f3\u30b7\u30e7\u30f3\uff08PCI\uff09\u5f8c\u306b\u5f93\u6765\u306e\u85ac\u3068\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u6ce8\u5c04\u3067\u6cbb\u7642\u3092\u53d7\u3051\u305f\u60a3\u800560\u4eba\u3092\u5bfe\u8c61\u306b\u5225\u306eRCT\u304c\u5b9f\u65bd\u3055\u308c\u305f\u3002\u7d50\u679c\u306f\u3001\u8a66\u9a13\u7fa4(88.3%)\u306b\u304a\u3051\u308b\u5fc3\u6a5f\u80fd\u30af\u30e9\u30b9\u2266NYHA\u6a5f\u80fd\u30af\u30e9\u30b9II\u306e\u5272\u5408\u304c\u5bfe\u7167\u7fa4(61.7%)\u3088\u308a\u3082\u9ad8\u3044\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u5fc3\u81d3\u6709\u5bb3\u4e8b\u8c61\uff08MI\u3001\u4e0d\u6574\u8108\u3001\u6b7b\u4ea1\uff09\u306e\u767a\u751f\u7387\u306f\u3001\u5bfe\u7167\u7fa4\uff0821.7%\uff09\u3068\u6bd4\u8f03\u3057\u3066\u8a66\u9a13\u7fa4\uff086.7%\uff09\u306e\u65b9\u304c\u4f4e\u304b\u3063\u305f\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B87\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30e4\u30f3\u3068\u30c1\u30a7\u30f3\u30012013<\/a>\uff09\u3002\u9759\u8108\u5185\u8840\u6813\u6eb6\u89e3\u7642\u6cd5\u304c\u6210\u529f\u3057\u305fAMI\u60a3\u8005\u306e\u904b\u52d5\u8010\u5bb9\u80fd\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u52b9\u679c\u3092\u89b3\u5bdf\u3059\u308b\u305f\u3081\u306b\u3001\u5225\u306eRCT\u304c\u5b9f\u65bd\u3055\u308c\u305f\u3002 98\u4eba\u306e\u60a3\u8005\u304c\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u3068\u5f93\u6765\u306e\u6cbb\u7642\u3092\u4f75\u7528\u3059\u308b\u7fa4\u3001\u307e\u305f\u306f\u5f93\u6765\u306e\u6cbb\u7642\u306e\u307f\u309214\u65e5\u9593\u53d7\u3051\u308b\u7fa4\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u5f53\u3066\u3089\u308c\u305f\u3002\u30c8\u30ec\u30c3\u30c9\u30df\u30eb\u904b\u52d5\u8a66\u9a13\u306e\u7d50\u679c\u300136\u65e5\u76ee\u306b\u4f75\u7528\u7fa4\u3067\u306f\u5bfe\u7167\u7fa4\u306b\u6bd4\u3079\u3001\u904b\u52d5\u8a98\u767a\u6027\u5fc3\u96fb\u56f3ST\u4f4e\u4e0b\u6642\u9593\uff08\u22670.1mV\uff09\u304c\u6709\u610f\u306b\u5ef6\u9577\u3057\u3001ST\u4f4e\u4e0b\u671f\u9593\u304c\u77ed\u7e2e\u3055\u308c\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002 \u3002\u3057\u304b\u3057\u300114\u65e5\u76ee\u306b\u306f\u5927\u304d\u306a\u5909\u5316\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306b\u306f\u6301\u7d9a\u7684\u306a\u52b9\u679c\u304c\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B76\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ef\u30f3\u4ed6\u30012009<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.e.e\" class=\"sec\">\n<h3 id=\"sec-a.l.e.etitle\">\u9ad8\u8840\u5727<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u9ad8\u8840\u5727\u306b\u3088\u308a\u5e74\u9593780\u4e07\u4eba\u304c\u6b7b\u4ea1\u3057\u3066\u304a\u308a\u3001\u4e16\u754c\u4e2d\u306e\u7dcf\u6b7b\u4ea1\u8005\u6570\u306e12.8%\u3092\u5360\u3081\u3066\u3044\u307e\u3059\u3002\u8840\u5727\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u306a\u3044\u4eba\u53e3\u306e\u898f\u6a21\u306f\u30011980 \u5e74\u304b\u3089 2008 \u5e74\u306e\u9593\u306b 600 \u4e07\u4eba\u304b\u3089 10 \u5104\u4eba\u8fd1\u304f\u306b\u5897\u52a0\u3057\u307e\u3057\u305f (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B43\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30e1\u30f3\u30c7\u30a3\u30b9\u4ed6\u30012011<\/a>\uff09\u3002\u8840\u5727\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u306a\u3044\u3068\u3001CHD\u3084\u8133\u5352\u4e2d\u3060\u3051\u3067\u306a\u304f\u3001\u5fc3\u4e0d\u5168\u3001\u6162\u6027\u814e\u81d3\u75c5\u306a\u3069\u306e\u4e3b\u306a\u539f\u56e0\u3068\u306a\u308a\u307e\u3059(<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B52\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30dd\u30fc\u30eb\u30bf\u30fc\u4ed6\u30012015<\/a>\uff09\u3002\u6f22\u65b9\u85ac\u3068\u964d\u5727\u85ac\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u6cbb\u7642\u306f\u3001\u8840\u5727\u3068\u305d\u308c\u306b\u4f34\u3046\u5408\u4f75\u75c7\u3092\u5236\u5fa1\u3059\u308b\u305f\u3081\u306e\u7d71\u5408\u7642\u6cd5\u3068\u3057\u3066\u3001\u6771\u6d0b\u3068\u897f\u6d0b\u306e\u4e21\u65b9\u3067\u307e\u3059\u307e\u3059\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B8\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30a8\u30eb\u30f3\u30b9\u30c8\u30012005<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B75\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ef\u30f3\u4ed6\u30012012<\/a>\uff09\u3002\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001\u672c\u614b\u6027\u9ad8\u8840\u5727\u75c7\u306e\u9ad8\u9f62\u60a3\u8005\u306e\u814e\u6a5f\u80fd\u306b\u5bfe\u3059\u308b\u30a8\u30ea\u30b2\u30ed\u30f3\u6ce8\u5c04\u306e\u52b9\u679c\u304c\u7814\u7a76\u3055\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u30a8\u30ea\u30b2\u30ed\u30f3\u6ce8\u5c04\u6db2\uff08\u4e3b\u6210\u5206\u306f\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\uff09\uff0840ml\u3001qd\uff09\u304c\u30a8\u30ca\u30e9\u30d7\u30ea\u30eb\uff0820mg\u3001qd\uff09\u3068\u540c\u69d8\u306e\u964d\u5727\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u304c\u5b9f\u8a3c\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u5c3f\u4e2dNAG\u3068\u03b2<sub>2<\/sub>-MG \u306f\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u7fa4\u3067\u6709\u610f\u306b\u6e1b\u5c11\u3057\u3001\u3053\u308c\u306f\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u3053\u308c\u3089\u306e\u60a3\u8005\u306e\u5c3f\u7d30\u7ba1\u6a5f\u80fd\u3092\u6539\u5584\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B72\" aria-expanded=\"false\" aria-haspopup=\"true\">\u738b\u30012000<\/a>\uff09\u3002\u5225\u306eRCT\u306f\u3001\u6025\u6027\u9ad8\u8840\u5727\u6027\u8133\u51fa\u8840\u60a3\u8005\u306b\u304a\u3051\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u6709\u52b9\u6027\u3092\u8abf\u67fb\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u60a3\u8005\u306f\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u3068\u901a\u5e38\u306e\u897f\u6d0b\u533b\u5b66\u306e\u3044\u305a\u308c\u304b\u3067\u6cbb\u7642\u3055\u308c\u307e\u3057\u305f\uff08<em>n<\/em>\u00a0= 39) \u307e\u305f\u306f\u65e5\u5e38\u7684\u306a\u897f\u6d0b\u533b\u5b66\u5358\u72ec (<em>n<\/em>\u00a0= 39) 2 \u9031\u9593\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u7fa4\u306e\u8840\u816b\u91cf\u3001\u6d6e\u816b\u9762\u7a4d\u3001\u304a\u3088\u3073\u30b9\u30ab\u30f3\u30b8\u30ca\u30d3\u30a2\u8133\u5352\u4e2d\u30b9\u30b1\u30fc\u30eb\uff08SSS\uff09\u306e\u7d50\u679c\u306f\u3001\u5bfe\u7167\u7fa4\u3088\u308a\u3082\u7d71\u8a08\u7684\u306b\u826f\u597d\u3067\u3057\u305f\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B63\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30b7\u30fc\u3068\u30c7\u30a3\u30f3\u30012009<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.e.f\" class=\"sec\">\n<h3 id=\"sec-a.l.e.ftitle\">\u4e0d\u6574\u8108<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u81e8\u5e8a\u73fe\u5834\u3067\u306f\u3001\u4e0d\u6574\u8108\u306e\u6cbb\u7642\u6cd5\u306e\u307b\u3068\u3093\u3069\u306f\u533b\u5b66\u7684\u306b\u9069\u5fdc\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u3057\u3001AF \u306f\u91cd\u7be4\u306a\u4e0d\u6574\u8108 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B45\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30de\u30f3\u30ac\u30fc\u4ed6\u30012014<\/a>\uff09\u306b\u5bfe\u51e6\u3059\u308b\u306e\u306f\u307e\u3060\u7c21\u5358\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u5fc3\u623f\u7d30\u52d5\u306f\u5fc3\u81d3\u7a81\u7136\u6b7b\u306e\u4e3b\u306a\u539f\u56e0\u3067\u3042\u308a\u3001\u4e16\u754c\u4e2d\u306e CVD \u306b\u3088\u308b\u6b7b\u4ea1\u306e\u534a\u6570\u3092\u5360\u3081\u3066\u3044\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B42\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30e1\u30fc\u30e9\u30012007<\/a>\uff09\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u6297\u4e0d\u6574\u8108\u52b9\u679c\u306f\u3044\u304f\u3064\u304b\u306e\u52d5\u7269\u5b9f\u9a13\u3067\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u81e8\u5e8a\u8a66\u9a13\u306f\u3044\u304f\u3064\u304b\u3042\u308a\u307e\u3059\u3002\u30a8\u30ea\u30b2\u30ed\u30f3\u6ce8\u5c04\uff0836mg\u3001\u70b9\u6ef4\u3001\u6bce\u65e5\uff09\u30922\u9031\u9593\u53d7\u3051\u305f\u6301\u7d9a\u6027\u5fc3\u623f\u7d30\u52d5\u306e\u9ad8\u9f62\u60a3\u800530\u4eba\u304b\u3089\u306a\u308b\u4e00\u9023\u306e\u75c7\u4f8b\u3067\u306f\u3001\u6cbb\u7642\u5f8c\u306b\u60a3\u8005\u306e\u5fc3\u62cd\u6570\u304c115.4\u00b18.2\u304b\u308983.3\u00b17.6\u306b\u6e1b\u5c11\u3057\u305f\u3068\u5831\u544a\u3057\u305f\u3002\u5831\u544a\u3055\u308c\u305f\u6709\u5bb3\u4e8b\u8c61\u306b\u306f\u3001\u3081\u307e\u3044\u306e 3 \u4f8b\u304c\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306f\u81ea\u7136\u306b\u89e3\u6d88\u3055\u308c\u307e\u3057\u305f (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B19\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30cf\u30f3\u30011999<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.e.g\" class=\"sec\">\n<h3 id=\"sec-a.l.e.gtitle\">\u9ad8\u8102\u8840\u75c7<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u9ad8\u8102\u8840\u75c7\u306f\u8840\u6db2\u4e2d\u306e\u8102\u8cea\u306e\u7570\u5e38\u306a\u5897\u52a0\u3067\u3042\u308a\u3001\u901a\u5e38\u306f\u8840\u6e05\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068TG\u306e\u4e0a\u6607\u3092\u6307\u3057\u307e\u3059\u3002\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068TG\u304c\u591a\u91cf\u306b\u3042\u308b\u3068\u3001CVD\u306e\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3057\u307e\u3059\u3002\u30c7\u30fc\u30bf\u306b\u3088\u308b\u3068\u3001\u8840\u6e05\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c 10% \u6e1b\u5c11\u3059\u308b\u3068\u300140 \u6b73\u7537\u6027\u306e\u5fc3\u81d3\u75c5\u306e\u6709\u75c5\u7387\u306f 5 \u5e74\u4ee5\u5185\u306b 50% \u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B43\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30e1\u30f3\u30c7\u30a3\u30b9\u4ed6\u30012011<\/a>\uff09\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u8840\u6e05\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068TG\u306e\u30ec\u30d9\u30eb\u3092\u5236\u5fa1\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u52d5\u7269\u5b9f\u9a13\u3067\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u8840\u6e05\u8102\u8cea\u306e\u4e0a\u6607\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u306e\u306b\u5f79\u7acb\u3064\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u9ad8\u8102\u8840\u75c7\u60a3\u8005\u306b\u5bfe\u3059\u308b\u305d\u306e\u52b9\u679c\u3092\u89b3\u5bdf\u3059\u308b\u81e8\u5e8a\u7814\u7a76\u3082\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3 25 mg \u3092 2 \u9031\u9593\u6bce\u65e5\u6295\u4e0e\u3057\u305f\u5f8c\u3001\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb (TC)\u3001LDL-c\u3001\u304a\u3088\u3073 TG \u306e\u30ec\u30d9\u30eb\u304c\u4f4e\u4e0b\u3057\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u5bfe\u7167\u7684\u306b\u3001HDL-c \u30ec\u30d9\u30eb\u306f\u5897\u52a0\u3057\u307e\u3057\u305f (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B91\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30e6\u30a6\u30012011<\/a>\uff09\u3002\u5225\u306e\u8a66\u9a13\u3067\u306f\u3001\u30a8\u30ea\u30b2\u30ed\u30f3\u6ce8\u5c04\uff0830 mg\u3001\u6bce\u65e5\uff09\u30922\u9031\u9593\u53d7\u3051\u305f\u9ad8\u8102\u8840\u75c7\u306e\u9ad8\u9f62\u60a3\u800536\u4eba\u3092\u7814\u7a76\u3057\u307e\u3057\u305f\u3002\u540c\u69d8\u306e\u7d50\u679c\u304c\u5f97\u3089\u308c\u307e\u3057\u305f (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B82\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30a6\u30a7\u30f3\u3068\u30eb\u30a2\u30f3\u30012004<\/a>\uff09\u3002\u5225\u306e RCT \u306f\u3001\u9ad8\u8102\u8840\u75c7\u3092\u4f34\u3046\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u60a3\u8005\u306b\u304a\u3051\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u52b9\u679c\u3092\u8abf\u67fb\u3059\u308b\u305f\u3081\u306b\u8a2d\u8a08\u3055\u308c\u307e\u3057\u305f\u3002\u8a66\u9a13\u30b0\u30eb\u30fc\u30d7\u3082\u5bfe\u7167\u30b0\u30eb\u30fc\u30d7\u3082\u30b9\u30bf\u30c1\u30f3\u3092\u6295\u4e0e\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u8840\u6e05\u8102\u8cea\u3001WBV\u3001\u304a\u3088\u3073 PV \u306e\u7d50\u679c\u306f\u3001\u8a66\u9a13\u30b0\u30eb\u30fc\u30d7\u5185\u3067\u7d71\u8a08\u7684\u306b\u6709\u610f\u306a\u5dee\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u72ed\u5fc3\u75c7\u306e\u6301\u7d9a\u671f\u9593\u3082\u30c6\u30b9\u30c8\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u6e1b\u5c11\u3057\u307e\u3057\u305f\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B51\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30da\u30f3\u3068\u30a4\u30a7\u30012011<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.e.h\" class=\"sec\">\n<h3 id=\"sec-a.l.e.htitle\">\u30a6\u30a4\u30eb\u30b9\u6027\u5fc3\u7b4b\u708e<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u30a6\u30a4\u30eb\u30b9\u6027\u5fc3\u7b4b\u708e\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u306b\u3088\u308b\u5fc3\u7b4b\u306e\u708e\u75c7\u3067\u3059\u3002\u5fc3\u4e0d\u5168\u306e\u767a\u75c7\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002\u73fe\u5728\u3001\u5bfe\u75c7\u7642\u6cd5\u304c VMC \u306e\u4e3b\u306a\u6cbb\u7642\u6cd5\u3067\u3042\u308a\u3001\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\u9759\u6ce8 (IVIG) \u3084\u6f22\u65b9\u85ac\u306a\u3069\u306e\u4ed6\u306e\u6cbb\u7642\u6cd5\u306f\u3001\u8a3c\u62e0\u306b\u57fa\u3065\u3044\u305f\u5229\u70b9\u3092\u793a\u3057\u3066\u3044\u307e\u305b\u3093 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B55\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ed\u30d3\u30f3\u30bd\u30f3\u4ed6\u30012005<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B36\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ea\u30e5\u30fc\u4ed6\u30012012<\/a>\uff09\u3002\u3044\u304f\u3064\u304b\u306e\u7814\u7a76\u3067\u3001VMC \u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u52b9\u679c\u304c\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30e9\u30f3\u30c0\u30e0\u5316\u5bfe\u7167\u8a66\u9a13\u306f\u3001VMC \u306e\u5c0f\u5150\u306e\u5fc3\u62cd\u6570\u306e\u6e1b\u901f\u80fd\u529b (DC\u3001\u81ea\u5f8b\u795e\u7d4c\u7dca\u5f35\u3092\u5b9a\u91cf\u7684\u306b\u691c\u51fa\u3059\u308b\u6280\u8853) \u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u6ce8\u5c04\u306e\u52b9\u679c\u3092\u7814\u7a76\u3059\u308b\u305f\u3081\u306b\u8a2d\u8a08\u3055\u308c\u307e\u3057\u305f\u3002\u6bce\u65e5 10 mg \u306e\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u3092\u6295\u4e0e\u3057\u307e\u3057\u305f (<em>n<\/em>\u00a0= 30) \u307e\u305f\u306f 100 U \u30b3\u30a8\u30f3\u30b6\u30a4\u30e0 A (CoA) \u304a\u3088\u3073 40 mg \u30a2\u30c7\u30ce\u30b7\u30f3\u4e09\u30ea\u30f3\u9178 (ATP) (<em>n<\/em>\u00a0= 30) 2 \u9031\u9593\u3002\u7d50\u679c\u306f\u3001\u5bfe\u7167\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u7fa4\u3067 DC \u304c\u6709\u610f\u306b\u4e0a\u6607\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u7814\u7a76\u8005\u3089\u306f\u307e\u305f\u3001\u5bfe\u7167\u7fa4\u3088\u308a\u3082\u8a66\u9a13\u7fa4\u306e\u65b9\u304cCK-MB\u304c\u9855\u8457\u306b\u6e1b\u5c11\u3057\u3066\u3044\u308b\u3053\u3068\u3082\u767a\u898b\u3057\u305f(<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B17\" aria-expanded=\"false\" aria-haspopup=\"true\">Gu \u4ed6\u30012014<\/a>\uff09\u3002\u5225\u306e\u7814\u7a76\u3067\u3082\u540c\u69d8\u306e\u7d50\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7814\u7a76\u8005\u3089\u306f\u3001\u5fc3\u7b4b\u5c64\u306e\u708e\u75c7\u306e\u7a0b\u5ea6\u3092\u53cd\u6620\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3042\u308bTNF-\u03b1\u3092\u5b9f\u8a3c\u3057\u305f(<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B26\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ec\u30f3\u30c4\u30a9\u307b\u304b\u30012001<\/a>\uff09\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u7fa4\u3067\u306f\u9855\u8457\u306b\u6e1b\u5c11\u3057\u307e\u3057\u305f\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B78\" aria-expanded=\"false\" aria-haspopup=\"true\">\u738b\u3068\u738b\u30012009<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.e.i\" class=\"sec\">\n<h3 id=\"sec-a.l.e.ititle\">\u6162\u6027\u5fc3\u4e0d\u5168<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u6162\u6027\u5fc3\u4e0d\u5168\u306f\u3001\u307b\u3068\u3093\u3069\u306e CVD \u306e\u672b\u671f\u6bb5\u968e\u3067\u767a\u751f\u3059\u308b\u3053\u3068\u304c\u3088\u304f\u3042\u308a\u307e\u3059\u3002\u75ab\u5b66\u8abf\u67fb\u306b\u3088\u308b\u3068\u3001\u5148\u9032\u56fd\u306e\u6210\u4eba\u306eCHF\u6709\u75c5\u7387\u306f\u7d042%\u3001\u4e2d\u56fd\u3067\u306f0.9%\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B16\" aria-expanded=\"false\" aria-haspopup=\"true\">Gu \u3089\u30012002<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B41\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30de\u30af\u30de\u30ea\u30fc\u3068\u30d5\u30a7\u30d5\u30a1\u30fc\u30012005<\/a>\uff09\u3002\u60a3\u8005\u306e\u3046\u3061 30 \uff5e 40% \u304c CVD \u8a3a\u65ad\u5f8c 1 \u5e74\u4ee5\u5185\u306b\u6b7b\u4ea1\u3057\u307e\u3059\u304c\u3001\u6b7b\u4ea1\u7387\u306f\u5e74\u9593 10% \u672a\u6e80\u3067\u3059\u3002\u89e3\u6c7a\u3059\u3079\u304d\u91cd\u8981\u306a\u554f\u984c\u306f\u3001\u6c17\u5206\u969c\u5bb3\u306a\u3069\u306eQOL\u3078\u306e\u5f71\u97ff\u3067\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B46\" aria-expanded=\"false\" aria-haspopup=\"true\">\u56fd\u7acb\u81e8\u5e8a\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u30bb\u30f3\u30bf\u30fc\u30012010 \u5e74<\/a>\uff09\u3002\u30e9\u30f3\u30c0\u30e0\u5316\u5bfe\u7167\u8a66\u9a13\u3067\u306f\u3001\u6b63\u5e38\u99c6\u51fa\u7387\uff08HF-NEF\uff09\u3092\u6709\u3059\u308b\u5fc3\u4e0d\u5168\u306eNYHA III\uff5eIV\u671f\u60a3\u8005100\u4eba\u306b\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f340 mg\/\u65e5\u3068\u901a\u5e38\u306e\u85ac\u5264\u3092\u4f75\u7528\u3059\u308b\u304b\u3001\u901a\u5e38\u306e\u85ac\u5264\u306e\u307f\u309210\u65e5\u9593\u670d\u7528\u3059\u308b\u3088\u3046\u6307\u793a\u3057\u305f\u3002\u7d50\u679c\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u306f\u3001B \u578b\u30ca\u30c8\u30ea\u30a6\u30e0\u5229\u5c3f\u30da\u30d7\u30c1\u30c9 (BNP) \u304c\u8a66\u9a13\u30b0\u30eb\u30fc\u30d7\u3067\u3088\u308a\u6e1b\u5c11\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u305f\u3060\u3057\u3001\u30c6\u30b9\u30c8 \u30b0\u30eb\u30fc\u30d7\u3068\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb \u30b0\u30eb\u30fc\u30d7\u306e\u9593\u3067\u3001LVEF \u3068\u5de6\u5fc3\u5ba4\u62e1\u5f35\u672b\u671f\u5bb9\u7a4d (LVEDV) \u306b\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u606f\u5207\u308c\u3001\u80f8\u306e\u5727\u8feb\u611f\u3001\u75b2\u52b4\u611f\u3001\u8131\u529b\u611f\u306a\u3069\u306e\u5178\u578b\u7684\u306a\u75c7\u72b6\u3082\u3001\u30c6\u30b9\u30c8\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u5bfe\u7167\u30b0\u30eb\u30fc\u30d7\u3088\u308a\u3082\u5927\u5e45\u306b\u6539\u5584\u3055\u308c\u307e\u3057\u305f\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B93\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f35 F.\u30012014<\/a>\uff09\u3002 1\u4ef6\u306eRCT\u304c\u3001\u30e9\u30f3\u30c0\u30e0\u306b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\uff0850mg\u3001qd\uff09\u3068\u5f93\u6765\u85ac\u3001\u307e\u305f\u306f\u5f93\u6765\u85ac\u5358\u72ec\u30922\u9031\u9593\u6295\u4e0e\u3055\u308c\u305fNYHA II\uff5eIII\u671f\u60a3\u8005126\u540d\u3092\u5bfe\u8c61\u306b\u5b9f\u65bd\u3055\u308c\u305f\u3002\u7d50\u679c\u306f\u3001\u4f75\u7528\u30b0\u30eb\u30fc\u30d7\u306eLVEF\u304a\u3088\u30736\u5206\u9593\u6b69\u884c\u30c6\u30b9\u30c8(6MWT)\u304c\u5bfe\u7167\u30b0\u30eb\u30fc\u30d7\u3068\u6bd4\u8f03\u3057\u3066\u8457\u3057\u304f\u512a\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f(<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B68\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30c6\u30a3\u30a2\u30f3\u30012010<\/a>\uff09\u3002\u5225\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001NYHA III\uff5eIV\u671f\u306e\u91cd\u5ea6\u5fc3\u4e0d\u5168\u60a3\u800546\u540d\u3092\u5bfe\u8c61\u306b\u7814\u7a76\u304c\u884c\u308f\u308c\u3001\u540c\u69d8\u306e\u7d50\u679c\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B27\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ea\u30fc\u30012007<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.e.j\" class=\"sec sec-last\">\n<h3 id=\"sec-a.l.e.jtitle\">\u80ba\u5fc3\u75be\u60a3<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u80ba\u5fc3\u75be\u60a3\u306f\u5fc3\u4e0d\u5168\u3084\u547c\u5438\u4e0d\u5168\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u5727\u529b\u5f8c\u8ca0\u8377\u306f\u75c5\u6c17\u306e\u521d\u671f\u6bb5\u968e\u3067\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B69\" aria-expanded=\"false\" aria-haspopup=\"true\">Voelkel \u4ed6\u30012013<\/a>\uff09\u3002\u73fe\u5728\u3001\u6297\u751f\u7269\u8cea\u3001\u9178\u7d20\u7642\u6cd5\u3001\u6297\u51dd\u56fa\u85ac\u3001\u8840\u7ba1\u62e1\u5f35\u85ac\u304c PHD \u306e\u4e3b\u306a\u6cbb\u7642\u6cd5\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3044\u304f\u3064\u304b\u306e\u7814\u7a76\u3067\u306f\u3001\u3053\u306e\u75c5\u6c17\u306b\u5bfe\u3059\u308b\u5f93\u6765\u306e\u6cbb\u7642\u6cd5\u3068\u6f22\u65b9\u85ac\uff08\u30b7\u30a7\u30f3\u30de\u30a4\u6ce8\u5c04\uff09\u306e\u4f75\u7528\u306e\u5b89\u5168\u6027\u3068\u6709\u52b9\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B62\" aria-expanded=\"false\" aria-haspopup=\"true\">Shi \u4ed6\u30012015<\/a>\uff09\u3002 PHD\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u52b9\u679c\u3092\u5831\u544a\u3059\u308b\u7814\u7a76\u3082\u3044\u304f\u3064\u304b\u3042\u308a\u307e\u3059\u3002\u30e9\u30f3\u30c0\u30e0\u5316\u5bfe\u7167\u8a66\u9a13\u3067\u306f\u3001\u5f93\u6765\u85ac\u3068 40 mg\/\u65e5\u306e\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u3001\u307e\u305f\u306f\u5f93\u6765\u85ac\u5358\u72ec\u3067 28 \u65e5\u9593\u6cbb\u7642\u3092\u53d7\u3051\u305f PHD \u60a3\u8005 83 \u4eba\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u52b9\u679c\u3092\u8abf\u67fb\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u5869\u57fa\u6027\u7dda\u7dad\u82bd\u7d30\u80de\u5897\u6b96\u56e0\u5b50\uff08bFGF\u3001\u8840\u7ba1\u5185\u76ae\u5897\u6b96\u56e0\u5b50\u3092\u8a98\u5c0e\u3067\u304d\u308b\u30dd\u30ea\u30da\u30d7\u30c1\u30c9\uff09\u3001\u9178\u7d20\u5206\u5727\uff08PaO<sub>2<\/sub>\uff09\u3001\u5e73\u5747\u80ba\u52d5\u8108\u5727\uff08mPAP\uff09\u306f\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u7fa4\u3067\u9855\u8457\u306b\u6539\u5584\u3055\u308c\u307e\u3057\u305f\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B13\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ac\u30aa\u3068\u30ea\u30e3\u30f3\u30012009<\/a>\uff09\u3002\u5225\u306e\u8a66\u9a13\u3067\u306f\u3001PHD\u60a3\u8005\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u52b9\u679c\u3082\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u8d64\u8840\u7403\u306e\u5909\u5f62\u6027\u3068\u767d\u8840\u7403\u306e\u6d3b\u6027\u5316\u306e\u7d50\u679c\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u7fa4\u3068\u5bfe\u7167\u7fa4\u306e\u9593\u3067\u6709\u610f\u306a\u5dee\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001\u8d64\u8840\u7403\u306e\u5909\u5f62\u80fd\u3068\u767d\u8840\u7403\u306e\u6d3b\u6027\u5316\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066 PHD \u306e\u9032\u884c\u3092\u9632\u3050\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u306f\u4ee3\u511f\u4e0d\u5168\u6162\u6027 PHD \u60a3\u8005\u306e\u8840\u6e05\u51dd\u56fa\u4ea2\u9032\u72b6\u614b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B25\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30b3\u30f3\u30b0\u4ed6\u30012006<\/a>\uff09\u3002\u3042\u308b\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001PHD \u306e\u6025\u6027\u5897\u60aa\u60a3\u8005\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u52b9\u679c\u3092\u8abf\u67fb\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u547c\u5438\u56f0\u96e3\u3001\u54b3\u3001\u6d6e\u816b\u3001\u30c1\u30a2\u30ce\u30fc\u30bc\u306a\u3069\u306e\u75c7\u72b6\u304c\u3001\u5bfe\u7167\u7fa4\u3088\u308a\u3082\u8a66\u9a13\u7fa4\u3067\u6539\u5584\u3055\u308c\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u30c6\u30b9\u30c8\u30b0\u30eb\u30fc\u30d7\u3067\u306f WBV \u3084 FIB \u306a\u3069\u306e\u3044\u304f\u3064\u304b\u306e\u6307\u6a19\u304c\u660e\u3089\u304b\u306b\u6e1b\u5c11\u3057\u3001\u8840\u6db2\u7c98\u5ea6\u306e\u6539\u5584\u304c\u5b9f\u8a3c\u3055\u308c\u307e\u3057\u305f (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B3\" aria-expanded=\"false\" aria-haspopup=\"true\">\u66f9\u4ed6\u30012006<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<div id=\"sec-a.l.f\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"sec-a.l.ftitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u6295\u4e0e\u91cf\u3068\u526f\u4f5c\u7528<\/h2>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001\u6ce8\u5c04\u304a\u3088\u3073\u7d4c\u53e3\u6295\u4e0e\u306e\u5f62\u3067\u30af\u30ea\u30cb\u30c3\u30af\u3067\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6ce8\u5c04\u306e\u5834\u5408\u306f1\u56de1\u65e55\uff5e20mg\u3001\u7d4c\u53e3\u6295\u4e0e\u306e\u5834\u5408\u306f1\u65e5120\uff5e240mg\u30923\u56de\u306b\u5206\u3051\u3066\u6295\u4e0e\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6c34\u6eb6\u6027\u304c\u4f4e\u304f\u3001\u751f\u7269\u5b66\u7684\u5229\u7528\u80fd\u304c\u4f4e\u3044\u305f\u3081\u00a0<em>\u751f\u4f53\u5185<\/em>\u3001\u5206\u6563\u9320\u5264\u3001\u30c9\u30ed\u30c3\u30d7\u30d4\u30eb\u3001\u30ea\u30dd\u30bd\u30fc\u30e0\u3001\u30ca\u30ce\u7c92\u5b50\u3001\u30ca\u30ce\u30a8\u30de\u30eb\u30b8\u30e7\u30f3\u3001\u8102\u8cea\u30a8\u30de\u30eb\u30b8\u30e7\u30f3\u306a\u3069\u3001\u591a\u304f\u306e\u65b0\u3057\u3044\u9001\u9054\u65b9\u6cd5\u304c\u8a2d\u8a08\u304a\u3088\u3073\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B103\" aria-expanded=\"false\" aria-haspopup=\"true\">Zhong \u4ed6\u30012005<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B50\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30d1\u30c6\u30eb\u307b\u304b\u30012012<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B39\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30de\u4ed6\u30012015<\/a>\uff09\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u526f\u4f5c\u7528\u306f\u4e3b\u306b\u6ce8\u5c04\u4e2d\u306b\u767a\u751f\u3057\u307e\u3059\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u526f\u4f5c\u7528\u306b\u95a2\u3059\u308b\u3042\u308b\u30e1\u30bf\u5206\u6790\u306b\u306f\u30011,761 \u4eba\u306e\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f 33 \u4ef6\u306e\u81e8\u5e8a\u7814\u7a76\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u5168\u4f53\u3068\u3057\u3066\u300172 \u4ef6\u306e\u526f\u4f5c\u7528\u304c\u5831\u544a\u3055\u308c\u3001\u767a\u751f\u7387\u306f 4.09% \u3067\u3057\u305f\u3002\u526f\u4f5c\u7528\u306b\u306f\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u3001\u76ae\u819a\u306e\u304b\u3086\u307f\u3001\u767a\u75b9\u3001\u9854\u9762\u7d05\u6f6e\u3001\u80f8\u90e8\u5727\u8feb\u611f\u3001\u52d5\u60b8\u3001\u3081\u307e\u3044\/\u3081\u307e\u3044\u3001\u982d\u75db\u3001\u80c3\u8178\u969c\u5bb3\u306a\u3069\u304c\u542b\u307e\u308c\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u7814\u7a76\u8005\u3089\u306f\u3001\u7279\u306b 15 \u65e5\u4ee5\u5185\u306e\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u6ce8\u5c04\u306e\u526f\u4f5c\u7528\u306b\u3064\u3044\u3066\u306f\u3001\u5bfe\u5fdc\u3059\u308b\u85ac\u5264\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306a\u5dee\u304c\u306a\u3044\u3053\u3068\u3082\u767a\u898b\u3057\u307e\u3057\u305f\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B10\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30d5\u30a7\u30f3\u4ed6\u30012016<\/a>\uff09\u3002\u85ac\u7269\u76f8\u4e92\u4f5c\u7528\u306b\u95a2\u3057\u3066\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001CYP1A2\u306b\u3088\u3063\u3066\u5a92\u4ecb\u3055\u308c\u308b\u30d5\u30a7\u30ca\u30bb\u30c1\u30f3\u4ee3\u8b1d\u3092\u77ed\u671f\u7684\u306b\u963b\u5bb3\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u00a0<em>\u8a66\u9a13\u7ba1\u5185\u3067<\/em>\u00a0\u5b9f\u9a13\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B53\" aria-expanded=\"false\" aria-haspopup=\"true\">\u79e6\u3089\u30012012<\/a>) CYP3A4 \u306e\u6d3b\u6027\u3092\u963b\u5bb3\u3057\u307e\u3059\u3002\u00a0<em>\u751f\u4f53\u5185<\/em>\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u307e\u305f\u3001\u30e9\u30c3\u30c8\u306e\u30c0\u30d7\u30bd\u30f3\u306e\u8840\u6f3f\u6fc3\u5ea6\u3092\u5927\u5e45\u306b\u5897\u52a0\u3055\u305b\u307e\u3057\u305f\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B34\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ea\u30e5\u30fc\u4ed6\u30012013<\/a>\uff09\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u6ce8\u5c04\u306e\u81e8\u5e8a\u5b89\u5168\u6027\u3068\u5408\u7406\u7684\u306a\u9069\u7528\u3067\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u6b21\u306e\u85ac\u5264\u3068\u4e92\u63db\u6027\u304c\u306a\u3044\u3053\u3068\u304c\u660e\u78ba\u306b\u8ff0\u3079\u3089\u308c\u3066\u3044\u307e\u3059:\u30a2\u30f3\u30d4\u30b7\u30ea\u30f3\u30ca\u30c8\u30ea\u30a6\u30e0\u3001\u786b\u9178\u30b2\u30f3\u30bf\u30de\u30a4\u30b7\u30f3\u3001\u30af\u30ed\u30e9\u30e0\u30d5\u30a7\u30cb\u30b3\u30fc\u30eb\u3001\u4e73\u9178\u30b7\u30d7\u30ed\u30d5\u30ed\u30ad\u30b5\u30b7\u30f3\u3001\u786b\u9178\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u3001\u5869\u9178\u30d7\u30ed\u30ab\u30a4\u30f3\u3001\u30bb\u30d5\u30e9\u30b8\u30f3\u3001\u4f4e\u5206\u5b50\u91cf\u30c7\u30ad\u30b9\u30c8\u30e9\u30f3\u3001\u30d5\u30ed\u30bb\u30df\u30c9\u3001\u304a\u3088\u3073\u6c34\u7d20\u6dfb\u52a0\u9162\u9178\u30d7\u30ec\u30c9\u30cb\u30f3\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B100\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8d99\u307b\u304b\u30012008<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.g\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"sec-a.l.gtitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u7d50\u8ad6\u3068\u5c55\u671b<\/h2>\n<p>&nbsp;<\/p>\n<p class=\"p p-first\">\u4f1d\u7d71\u7684\u306a\u4e2d\u56fd\u533b\u5b66 (TCM) \u306f\u3001\u4e2d\u56fd\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u4e88\u9632\u3068\u6cbb\u7642\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u7d9a\u3051\u3066\u3044\u307e\u3059\u3002\u897f\u6d0b\u533b\u5b66\u3068\u306f\u7570\u306a\u308a\u3001TCM \u306e\u5168\u4f53\u7684\u304b\u3064\u76f8\u4e57\u7684\u306a\u6027\u8cea\u306f\u3001\u6570\u767e\u306e\u5316\u5408\u7269\u3092\u542b\u3080\u30cf\u30fc\u30d6\u6210\u5206\u304b\u3089\u751f\u3058\u3001\u8907\u6570\u306e\u5316\u5408\u7269\u304c\u8907\u6570\u306e\u7570\u306a\u308b\u6a19\u7684\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u75be\u60a3\u306b\u52b9\u679c\u3092\u767a\u63ee\u3057\u3001\u8907\u96d1\u306a\u75be\u60a3\u306e\u5168\u8eab\u7684\u4ecb\u5165\u306b\u304a\u3051\u308b\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u3092\u5411\u4e0a\u3055\u305b\u307e\u3059\u3002 \u3002\u3057\u304b\u3057\u3001TCM \u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u4f9d\u7136\u3068\u3057\u3066\u4e0d\u660e\u77ad\u306a\u305f\u3081\u3001\u4e16\u754c\u306e\u4ed6\u306e\u56fd\u3005\u304c TCM \u304c\u3069\u306e\u3088\u3046\u306b\u6a5f\u80fd\u3059\u308b\u304b\u3092\u7406\u89e3\u3057\u3001\u305d\u306e\u4e16\u754c\u7684\u306a\u9069\u7528\u3092\u963b\u6b62\u3059\u308b\u3053\u3068\u3092\u56f0\u96e3\u306b\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u6f22\u65b9\u85ac\u306e\u5305\u62ec\u7684\u306a\u7406\u89e3\u3092\u5f97\u308b\u306b\u306f\u3001\u30cf\u30fc\u30d6\u306e\u30ec\u30d9\u30eb\u3067\u306e\u7814\u7a76\u304c\u826f\u3044\u65b9\u6cd5\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u3001TCM \u306b\u304a\u3051\u308b\u8907\u5408\u51e6\u65b9\u3092\u7814\u7a76\u3059\u308b\u4e3b\u306a\u6226\u7565\u306e 1 \u3064\u306f\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u7814\u7a76\u3059\u308b\u3053\u3068\u3067\u3057\u305f\u3002\u8907\u6570\u306e\u5316\u5408\u7269\u304c\u5b58\u5728\u3059\u308b\u305f\u3081\u3001\u3069\u306e\u6210\u5206\u304c\u5b9f\u969b\u306e\u52b9\u679c\u3092\u751f\u307f\u51fa\u3057\u3066\u3044\u308b\u306e\u304b\u306f\u5e38\u306b\u4e0d\u660e\u3067\u3059\u3002\u6f22\u65b9\u85ac\u306e\u30e2\u30ce\u30de\u30fc\u6210\u5206\uff08CHM\uff09\u306f\u3001\u5929\u7136\u306e\u7d14\u7c8b\u8907\u5408\u85ac\u3068\u3057\u3066\u3082\u77e5\u3089\u308c\u3001\u6700\u8fd1\u5927\u304d\u306a\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u307e\u3059\u3002\u5929\u7136\u62bd\u51fa\u7269\u306e\u30a2\u30eb\u30c6\u30df\u30b7\u30cb\u30f3\u3068\u305d\u306e\u8a98\u5c0e\u4f53\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u6d3b\u6027\u3092\u901a\u3058\u3066\u75be\u60a3\u3092\u6cbb\u7642\u3067\u304d\u308b CHM \u306e\u30e2\u30ce\u30de\u30fc\u6210\u5206\u306e\u826f\u3044\u4f8b\u3067\u3042\u308a\u3001TCM \u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u3059\u308b\u305f\u3081\u306e\u826f\u3044\u51fa\u767a\u70b9\u3068\u306a\u308a\u5f97\u307e\u3059\u3002<\/p>\n<p>\u540c\u69d8\u306b\u3001\u5fc3\u8840\u7ba1\u4f5c\u7528\u3092\u6301\u3064 CHM \u306e\u591a\u6570\u306e\u5358\u91cf\u4f53\u6210\u5206\u304c\u904e\u53bb\u6570\u5341\u5e74\u306b\u308f\u305f\u3063\u3066\u7814\u7a76\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u305f\u3068\u3048\u3070\u3001\u30b5\u30eb\u30d3\u30a2\u30ce\u30fc\u30eb\u9178 B \u306b\u95a2\u3057\u3066\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\u304c\u5b9f\u65bd\u3055\u308c\u3066\u3044\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B74\" aria-expanded=\"false\" aria-haspopup=\"true\">Wang J. \u4ed6\u30012013<\/a>)\u3001\u30c6\u30c8\u30e9\u30e1\u30c1\u30eb\u30d4\u30e9\u30b8\u30f3(<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B44\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30df\u30f3\u4ed6\u30012016<\/a>),\u00a0<em>\u30aa\u30bf\u30cd\u30cb\u30f3\u30b8\u30f3<\/em>\u00a0\u30b5\u30dd\u30cb\u30f3\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B89\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30e4\u30f3\u4ed6\u30012014<\/a>\u305d\u306e\u3046\u3061\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u4e3b\u6210\u5206\u3067\u3042\u308b\u30b9\u30af\u30c6\u30e9\u30ea\u30f3\u306fCHM\u306e\u30e2\u30ce\u30de\u30fc\u6210\u5206\u306e\u4e00\u7a2e\u3067\u3042\u308a\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u8840\u7ba1\u62e1\u5f35\uff08\u52c3\u8d77\u6a5f\u80fd\u306e\u6539\u5584\uff09\u306b\u5927\u304d\u306a\u4f5c\u7528\u3092\u53ca\u307c\u3057\u307e\u3059\u3002 I\/R \u304b\u3089\u306e\u4fdd\u8b77\u3002\u6297\u51dd\u56fa\u304a\u3088\u3073\u6297\u8840\u6813\u75c7;\u5e73\u6ed1\u7b4b\u7d30\u80de\u306e\u79fb\u52d5\u3068\u5897\u6b96\u306e\u6e1b\u5c11\u3002\u6297\u5fc3\u81d3\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0;\u6297\u4e0d\u6574\u8108\u3001\u8840\u4e2d\u8102\u8cea\u306e\u6e1b\u5c11\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001\u305d\u306e\u6297\u708e\u75c7\u4f5c\u7528\u306b\u3088\u308a\u3001\u5fc3\u7b4b\u304a\u3088\u3073\u5185\u76ae\u69cb\u9020\u306b\u5bfe\u3059\u308b\u4fdd\u8b77\u52b9\u679c\u3082\u3042\u308a\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u81e8\u5e8a\u7814\u7a76\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3067\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u6700\u3082\u9855\u8457\u306a\u7279\u5fb4\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3001\u8133\u5352\u4e2d\u3001\u7cd6\u5c3f\u75c5\u306b\u95a2\u9023\u3059\u308b\u8840\u7ba1\u306e\u8abf\u7bc0\u306b\u304a\u3044\u3066\u8907\u6570\u306e\u6a5f\u80fd\u3092\u5b9f\u884c\u3067\u304d\u308b\u3053\u3068\u3067\u3042\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<p class=\"p p-last\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f CVD \u306e\u4e88\u9632\u3068\u6cbb\u7642\u306b\u304a\u3044\u3066\u5fc3\u81d3\u8840\u7ba1\u306b\u5e83\u7bc4\u56f2\u306e\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u304c\u3001\u8003\u616e\u3059\u3079\u304d\u554f\u984c\u3082\u3044\u304f\u3064\u304b\u3042\u308a\u307e\u3059\u3002\u307e\u305a\u3001\u6211\u3005\u304c\u30ec\u30d3\u30e5\u30fc\u3057\u305f\u4e0a\u8a18\u306e\u5b9f\u9a13\u7814\u7a76\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u5074\u9762\u306b\u7126\u70b9\u3092\u5f53\u3066\u3066\u304a\u308a\u3001\u65b9\u6cd5\u8ad6\u306e\u8cea\u304c\u4f4e\u3044\u305f\u3081\u306b\u6700\u7d42\u7684\u306a\u7d50\u8ad6\u3092\u5c0e\u304d\u51fa\u3059\u3053\u3068\u304c\u3067\u304d\u305f\u7814\u7a76\u306f\u307b\u3068\u3093\u3069\u306a\u304f\u3001\u4e21\u65b9\u306e\u7d50\u679c\u3092\u691c\u8a3c\u3057\u305f\u7814\u7a76\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u00a0<em>\u8a66\u9a13\u7ba1\u5185\u3067<\/em>\u00a0\u305d\u3057\u3066\u00a0<em>\u751f\u4f53\u5185<\/em>\u3002\u4ed6\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3088\u308a\u3082\u3001\u8840\u7ba1\u62e1\u5f35\u3001I\/R\u3001\u6297\u51dd\u56fa\u4f5c\u7528\u3001\u6297\u8840\u6813\u4f5c\u7528\u306e\u7279\u6027\u3092\u8abf\u67fb\u3059\u308b\u7814\u7a76\u304c\u591a\u6570\u3042\u308a\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u52d5\u7269\u5b9f\u9a13\u306b\u304a\u3051\u308b\u8102\u8cea\u4f4e\u4e0b\u52b9\u679c\u306b\u95a2\u3059\u308b\u7d50\u679c\u306f\u30012 \u3064\u306e\u7814\u7a76\u3067\u7570\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u305d\u306e\u95a2\u9023\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u8abf\u67fb\u3057\u305f\u7814\u7a76\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u7b2c\u4e8c\u306b\u3001\u7814\u7a76\u306f\u4e3b\u306b\u4e2d\u56fd\u3067\u767a\u8868\u3055\u308c\u305f\u305f\u3081\u3001\u5bfe\u7167\u3084\u30d7\u30e9\u30bb\u30dc\u306e\u6b20\u5982\u3001\u975e\u7121\u4f5c\u70ba\u5316\u3001\u975e\u76f2\u691c\u8a2d\u8a08\u3001\u304a\u3088\u3073\/\u307e\u305f\u306f\u5c11\u6570\u306e\u60a3\u8005\u30b5\u30f3\u30d7\u30eb\u306b\u3088\u3063\u3066\u8a3c\u62e0\u306e\u5f37\u5ea6\u304c\u5236\u9650\u3055\u308c\u307e\u3057\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u3001CVD\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3092\u8a55\u4fa1\u3059\u308b\u306b\u306f\u3001\u591a\u65bd\u8a2d\u5171\u540c\u3001\u5927\u898f\u6a21\u30b5\u30f3\u30d7\u30eb\u3001\u304a\u3088\u3073\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3092\u884c\u3046\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u7b2c\u4e09\u306b\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u526f\u4f5c\u7528\u306f\u307b\u3068\u3093\u3069\u304c\u6ce8\u5c04\u6642\u306b\u767a\u751f\u3057\u305f\u305f\u3081\u3001\u9069\u5207\u306a\u6295\u4e0e\u5f62\u614b\u3092\u8003\u616e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u306a\u304a\u3001\u6025\u6027\u8133\u51fa\u8840\u3084\u51fa\u8840\u50be\u5411\u306e\u3042\u308b\u60a3\u8005\u306f\u9664\u5916\u3057\u305f\u3002\u5168\u4f53\u3068\u3057\u3066\u3001CVD \u306e\u6cbb\u7642\u306b\u304a\u3051\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u4f7f\u7528\u3092\u8abf\u67fb\u3059\u308b\u3053\u3068\u306f\u975e\u5e38\u306b\u91cd\u8981\u3067\u3059\u3002\u305d\u308c\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u3053\u308c\u3089\u3059\u3079\u3066\u306e\u5dee\u3057\u8feb\u3063\u305f\u554f\u984c\u306f\u5c06\u6765\u306e\u7814\u7a76\u3067\u5bfe\u51e6\u3055\u308c\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.h\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"sec-a.l.htitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u8457\u8005\u306e\u5bc4\u7a3f<\/h2>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">JG \u3068 GC \u306f\u30ec\u30d3\u30e5\u30fc\u4f5c\u696d\u3092\u8a2d\u8a08\u3057\u307e\u3057\u305f\u3002 JG\u3001GC\u3001HH\u3001\u304a\u3088\u3073 CL \u306f\u3001\u3053\u306e\u30c8\u30d4\u30c3\u30af\u306b\u95a2\u3059\u308b\u5165\u624b\u53ef\u80fd\u306a\u6587\u732e\u3092\u691c\u8a0e\u3057\u3001\u8ad6\u6587\u3092\u57f7\u7b46\u3057\u307e\u3057\u305f\u3002 XX \u3068 JL \u306f\u539f\u7a3f\u306e\u79d1\u5b66\u7684\u57f7\u7b46\u306b\u8ca2\u732e\u3057\u307e\u3057\u305f\u3002 JG\u3001GC\u3001JW \u304c\u539f\u7a3f\u3092\u6539\u8a02\u3057\u307e\u3057\u305f\u3002\u8457\u8005\u5168\u54e1\u304c\u305d\u306e\u8ad6\u6587\u306e\u51fa\u7248\u3092\u627f\u8a8d\u3057\u307e\u3057\u305f\u3002 JG\u3001GC\u3001HH\u3001CL \u3082\u540c\u69d8\u306b\u3053\u306e\u4f5c\u696d\u306b\u8ca2\u732e\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.i\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"sec-a.l.ititle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u5229\u76ca\u76f8\u53cd\u306b\u95a2\u3059\u308b\u58f0\u660e<\/h2>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u8457\u8005\u3089\u306f\u3001\u6f5c\u5728\u7684\u306a\u5229\u76ca\u76f8\u53cd\u3068\u307f\u306a\u3055\u308c\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u5546\u696d\u7684\u307e\u305f\u306f\u91d1\u92ad\u7684\u95a2\u4fc2\u304c\u5b58\u5728\u3057\u306a\u3044\u72b6\u614b\u3067\u7814\u7a76\u304c\u5b9f\u65bd\u3055\u308c\u305f\u3053\u3068\u3092\u5ba3\u8a00\u3057\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"fn-group-a.m.a\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"fn-group-a.m.atitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u811a\u6ce8<\/h2>\n<div class=\"fm-sec half_rhythm small\">\n<p class=\"p p-first-last\"><strong>\u8cc7\u91d1\u8abf\u9054\u3002<\/strong>\u00a0\u3053\u306e\u8ad6\u6587\u306f\u3001The Innovative Funding for Ph.D. \u306e\u652f\u63f4\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u4e2d\u56fd\u4e2d\u533b\u79d1\u5b66\u9662\u306e\u5b66\u751f\u30012016CX003\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<div id=\"ref-list-a.m.b\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"ref-list-a.m.btitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u53c2\u8003\u6587\u732e<\/h2>\n<p>&nbsp;<\/p>\n<div id=\"reference-list\" class=\"ref-list-sec sec\">\n<ol class=\"back-ref-list\">\n<li id=\"B1\"><span class=\"mixed-citation\">\u30dc\u30fc\u30fb\u30ea\u30fc\u3001\u30b8\u30e3\u30aa\u30fb\u30ac\u3001\u30a4\u30f3\u30fbGT\u3001\u30b5\u30f3\u30fbHY\u3001\u30ac\u30aa\u30ea\u30f3\u30fb\u30b0\u3001\u30e4\u30f3\u30fbXL (2011)\u3002\u00a0<span class=\"ref-title\">\u30a6\u30b5\u30ae\u5fc3\u81d3\u306e\u80a5\u5927\u5fc3\u7b4b\u306b\u304a\u3051\u308b\u5fc3\u5ba4\u4e0d\u6574\u8108\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u9320\u5264\u306e\u52b9\u679c\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>J. Xinxiang Med.\u30b3\u30eb\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">2<\/span>\u00a0154-156\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.+Xinxiang+Med.+Coll.&amp;title=Effect+of+breviscapine+tablets+on+ventricular+arrhythmias+in+hypertrophic+myocardium+of+rabbit+heart.&amp;author=L.+I.+Bo&amp;author=G.+A.+Zhao&amp;author=G.+T.+Yin&amp;author=H.+Y.+Sun&amp;author=G.+U.+Gao-Ling&amp;volume=2&amp;publication_year=2011&amp;pages=154-156&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B2\"><span class=\"mixed-citation\">\u30dc\u30ed\u30c6\u30a3\u30fc\u30ca VM\u3001\u30ca\u30b8\u30d3 S.\u3001\u30d1\u30e9\u30c1\u30fc\u30ce JJ\u3001\u30d1\u30ac\u30fc\u30ce PJ\u3001\u30b3\u30fc\u30a8\u30f3 RA (1994)\u3002\u00a0<span class=\"ref-title\">\u4e00\u9178\u5316\u7a92\u7d20\u306f\u3001\u8840\u7ba1\u5e73\u6ed1\u7b4b\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u4f9d\u5b58\u6027\u30ab\u30ea\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u3092\u76f4\u63a5\u6d3b\u6027\u5316\u3057\u307e\u3059\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u81ea\u7136<\/em><\/span>\u00a0<span class=\"ref-vol\">368<\/span>\u00a0850 \uff5e 853 \u5e74\u3002 10.1038\/368850a0 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7512692\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1038%2F368850a0\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Nature&amp;title=Nitric+oxide+directly+activates+calcium-dependent+potassium+channels+in+vascular+smooth+muscle.&amp;author=V.+M.+Bolotina&amp;author=S.+Najibi&amp;author=J.+J.+Palacino&amp;author=P.+J.+Pagano&amp;author=R.+A.+Cohen&amp;volume=368&amp;publication_year=1994&amp;pages=850-853&amp;pmid=7512692&amp;doi=10.1038\/368850a0&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B3\"><span class=\"mixed-citation\">\u66f9\u64cdRB\u3001\u674e\u83efHE\u3001\u79c0\u93aeHE (2006)\u3002\u00a0<span class=\"ref-title\">\u80ba\u6027\u5fc3\u306e\u6025\u6027\u5897\u60aa\u671f\u306b\u5bfe\u3059\u308b\u30a8\u30ea\u30bb\u30ed\u30f3\u30fb\u30d6\u30ec\u30d3\u30b9\u30ab\u30d7\u30b9\u6ce8\u5c04\u306e\u6cbb\u7642\u52b9\u679c\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u4e2d\u56fd J. 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class=\"ref-title\">\u30e9\u30c3\u30c8\u306e\u5358\u96e2\u5fc3\u5ba4\u7b4b\u7d30\u80de\u306b\u304a\u3051\u308bI_(to)\u304a\u3088\u3073I_(k1)\u30c1\u30e3\u30cd\u30eb\u96fb\u6d41\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u5f71\u97ff\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u984e\u3002 \uff2a\uff0e\uff30\uff41\uff54\uff48\uff4f\uff50\uff48\uff59\uff53\uff49\uff4f\uff4c\uff0e<\/em><\/span>\u00a0<span class=\"ref-vol\">24<\/span>\u00a084\u301c88\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Chin.+J.+Pathophysiol.&amp;title=Effect+of+breviscapin+on+I_(to)+and+I_(k1)+channel+current+in+isolated+ventricular+myocytes+of+rats.&amp;author=C.+Y.+Deng&amp;author=C.+J.+Tang&amp;author=S.+J.+Kuang&amp;author=W.+M.+Qian&amp;author=L.+I.+Zi-Cheng&amp;volume=24&amp;publication_year=2008&amp;pages=84-88&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" 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href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Wien.+Med.+Wochenschr.&amp;title=Complementary\/alternative+medicine+for+hypertension:+a+mini-review.&amp;author=E.+Ernst&amp;volume=155&amp;publication_year=2005&amp;pages=386-391&amp;pmid=16392435&amp;doi=10.1007\/s10354-005-0205-1&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B9\"><span class=\"mixed-citation\">\u52d5\u8108\u6027\u9ad8\u8840\u5727\u75c7\u306e\u7ba1\u7406\u306e\u305f\u3081\u306e ESH\/ESC \u30bf\u30b9\u30af\u30d5\u30a9\u30fc\u30b9 (2013)\u3002\u00a0<span class=\"ref-title\">\u6b27\u5dde\u9ad8\u8840\u5727\u5b66\u4f1a (ESH) \u304a\u3088\u3073\u6b27\u5dde\u5fc3\u81d3\u75c5\u5b66\u4f1a (ESC) \u306e\u52d5\u8108\u6027\u9ad8\u8840\u5727\u75c7\u306e\u7ba1\u7406\u306b\u95a2\u3059\u308b 2013 \u5e74\u306e\u5b9f\u8df5\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3: 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rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Acta+Pharmacol.+Sin.&amp;title=Breviscapine+inhibits+high+glucose-induced+proliferation+and+migration+of+cultured+vascular+smooth+muscle+cells+of+rats+via+suppressing+the+erk1\/2+mapk+signaling+pathway.&amp;author=M.+He&amp;author=Z.+Xue&amp;author=J.+Li&amp;author=B.+Zhou&amp;volume=33&amp;publication_year=2012&amp;pages=606-614&amp;pmid=22465949&amp;doi=10.1038\/aps.2012.6&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B22\"><span class=\"mixed-citation\">\u4faf SS\u3001\u5f35 QH\u3001\u5f35 YQ (2009)\u3002\u00a0<span class=\"ref-title\">\u30c8\u30ed\u30f3\u30d3\u30f3\u8a98\u767a\u30e9\u30c3\u30c8\u5927\u52d5\u8108\u5e73\u6ed1\u7b4b\u7d30\u80de\u306e\u5897\u6b96\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304a\u3088\u3073\u30c8\u30ed\u30f3\u30d3\u30f3\u53d7\u5bb9\u4f53\u30aa\u30ea\u30b4\u30c7\u30aa\u30ad\u30b7\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306e\u52b9\u679c\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u5929\u6d25\u85ac\u5c40\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">19<\/span>\u00a06-9\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Tianjin+Pharm.&amp;title=The+effect+of+breviscapine+and+thrombin+receptor+oligo-deoxy-nucleotides+on+thrombin+induced+proliferation+of+rat+aortic+smooth+muscle+cells.&amp;author=S.+S.+Hou&amp;author=Q.+H.+Zhang&amp;author=Y.+Q.+Zhang&amp;volume=19&amp;publication_year=2009&amp;pages=6-9&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B23\"><span class=\"mixed-citation\">Jia JH\u3001Chen KP\u3001Chen SX\u3001Liu KZ\u3001Fan TL\u3001Chen YC (2008)\u3002\u00a0<span class=\"ref-title\">\u4f1d\u7d71\u7684\u306a\u6f22\u65b9\u85ac\u3067\u3042\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001\u7cd6\u5c3f\u75c5\u30e9\u30c3\u30c8\u306e\u5fc3\u7b4b\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u3092\u8efd\u6e1b\u3057\u307e\u3059\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u30a2\u30af\u30bf\u30fb\u30ab\u30eb\u30c7\u30a3\u30aa\u30eb\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">63<\/span>\u00a0757 \uff5e 762 \u5e74\u3002 10.2143\/AC.63.6.2033394 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19157172\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.2143%2FAC.63.6.2033394\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span 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class=\"ref-title\">\u975e\u4ee3\u511f\u6027\u6162\u6027\u80ba\u6027\u5fc3\u60a3\u8005\u306b\u304a\u3051\u308b\u8d64\u8840\u7403\u5909\u5f62\u80fd\u3001\u767d\u8840\u7403\u6d3b\u6027\u5316\u304a\u3088\u3073\u63a5\u7740\u5206\u5b50cd11b\u767a\u73fe\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u6ce8\u5c04\u306e\u52b9\u679c\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u5185\u90e8\u3002 J.\u30c8\u30e9\u30c7\u30a3\u30c3\u30c8\u3002\u984e\u3002\u533b\u5b66\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">28<\/span>\u00a0278\u2013281\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Int.+J.+Tradit.+Chin.+Med.&amp;title=Effect+of+breviscapine+injection+on+the+erythrocyte+deformability,+leukocyte+activation+and+adhesive+molecule+cd11b+expression+in+patients+with+decompensable+chronic+cor+pulmonale.&amp;author=Q.+F.+Kong&amp;author=L.+I.+Wei-Guo&amp;author=F.+Liu&amp;author=Y.+M.+Shen&amp;author=L.+I.+Feng-Lan&amp;volume=28&amp;publication_year=2006&amp;pages=278-281&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B26\"><span class=\"mixed-citation\">\u30ec\u30f3\u30be JC\u3001\u30d5\u30a7\u30a2\u30a6\u30a7\u30b6\u30fc DL\u3001\u30b7\u30a7\u30e9\u30e0 GR\u3001\u30ed\u30fc\u30bd\u30f3 CM (2001)\u3002\u00a0<span class=\"ref-title\">\u30ea\u30dd\u591a\u7cd6\u304a\u3088\u3073\u816b\u760d\u58ca\u6b7b\u56e0\u5b50\u3067\u51e6\u7f6e\u3057\u305f\u30de\u30a6\u30b9\u306b\u304a\u3051\u308b\u30de\u30a6\u30b9\u30b5\u30a4\u30c8\u30e1\u30ac\u30ed\u30a6\u30a4\u30eb\u30b9\u8a98\u767a\u6027\u5fc3\u7b4b\u708e\u306e\u514d\u75ab\u8abf\u7bc0\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u7d30\u80de\u3002\u30a4\u30e0\u30ce\u30fc\u30eb\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">213<\/span>\u00a052\uff5e61\u3002 10.1006\/cimm.2001.1859 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11747356\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1006%2Fcimm.2001.1859\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" 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class=\"ref-title\">\u30a4\u30ab\u30ea\u30a4\u30f3\u3068\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3068\u3001\u81ea\u7136\u767a\u75c7\u9ad8\u8840\u5727\u30e9\u30c3\u30c8\u306e\u52c3\u8d77\u6a5f\u80fd\u304c\u6539\u5584\u3055\u308c\u307e\u3059\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>J.\u30bb\u30c3\u30af\u30b9\u3002\u533b\u5b66\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">11<\/span>\u00a02143 \uff5e 2152 \u5e74\u3002 10.1111\/jsm.12614 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24912989\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1111%2Fjsm.12614\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" 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aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B58\"><span class=\"mixed-citation\">\u30eb\u30d1\u30ec\u30ea\u30a2 N.\u3001\u30c1\u30e3\u30a4 JT\u3001\u30d5\u30a3\u30c3\u30b7\u30e3\u30fc EA\u3001\u30c1\u30e7\u30fc\u30c9\u30ea\u30fc RP (2017)\u3002\u00a0<span class=\"ref-title\">\u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u304a\u3051\u308b\u708e\u75c7\u904e\u7a0b: \u6a19\u7684\u7642\u6cd5\u3078\u306e\u9053\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>Nature Reviews \u5fc3\u81d3\u5b66<\/em><\/span>\u00a0<span class=\"ref-vol\">14<\/span>\u00a0133-144\u3002 10.1038\/nrcardio.2017.33\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5525550\/\">PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27905474\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1038%2Fnrcardio.2017.33\" 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href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=eCAM&amp;title=Cardiovascular+effects+of+salvianolic+acid+B.&amp;author=J.+Wang&amp;author=X.+Xiong&amp;author=B.+Feng&amp;volume=2013&amp;issue=247948&amp;publication_year=2013&amp;doi=10.1155\/2013\/247948&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B75\"><span class=\"mixed-citation\">Wang J.\u3001Yao K.\u3001Yang X.\u3001Liu W.\u3001Feng B.\u3001Ma J. \u4ed6\uff082012\u5e74\uff09\u3002\u00a0<span class=\"ref-title\">\u672c\u614b\u6027\u9ad8\u8840\u5727\u75c7\u306e\u6cbb\u7642\u306e\u305f\u3081\u306e\u3001\u65b0\u3057\u3044\u7d71\u5408\u533b\u7642\u7642\u6cd5\u3067\u3042\u308b\u964d\u5727\u85ac\u3068\u7d44\u307f\u5408\u308f\u305b\u305f\u4e2d\u56fd\u306e\u7279\u8a31\u533b\u5b66\u5289\u5049\u5e1d\u9ec4\u4e38\uff1a\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u306e\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>eCAM<\/em><\/span>\u00a0<span class=\"ref-vol\">2012<\/span>:<span class=\"ref-iss\">714805<\/span>\u00a010.1155\/2012\/714805\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3520441\/\">PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23258998\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1155%2F2012%2F714805\" target=\"_blank\" rel=\"noopener 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href=\"https:\/\/doi.org\/10.1007%2Fs00592-009-0164-x\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Acta+Diabetol.&amp;title=Breviscapine+ameliorates+cardiac+dysfunction+and+regulates+the+myocardial+ca2+-cycling+proteins+in+streptozotocin-induced+diabetic+rats.&amp;author=M.+Wang&amp;author=W.+B.+Zhang&amp;author=J.+H.+Zhu&amp;author=G.+S.+Fu&amp;author=B.+Q.+Zhou&amp;volume=47&amp;publication_year=2010&amp;pages=209-218&amp;doi=10.1007\/s00592-009-0164-x&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B78\"><span class=\"mixed-citation\">\u738b SM\u3001\u738b DB (2009)\u3002\u00a0<span 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class=\"ref-title\">\u30e9\u30c3\u30c8\u5927\u52d5\u8108\u5e73\u6ed1\u7b4b\u306b\u304a\u3051\u308b\u30ab\u30eb\u30b7\u30a6\u30e0\u6d3b\u6027\u5316\u30ab\u30ea\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u6d3b\u6027\u5316\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\uff2a\uff0e\u30af\u30ea\u30f3\uff0e\u30ab\u30fc\u30c7\u30a3\u30aa\u30fc\u30eb\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">22<\/span>\u00a0351\u2013353\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.+Clin.+Cardiol.&amp;title=Activation+of+breviscapine+to+calcium-activated+potassium+channels+in+rat+aortic+smooth+muscle.&amp;author=L.+I.+Xiuqin&amp;volume=22&amp;publication_year=2006&amp;pages=351-353&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B85\"><span class=\"mixed-citation\">Xu-Feng LI\u3001Liu F.\u3001Jiang TL\u3001Wang ZJ\u3001Han YH\u3001Zhi-Hong WU (2010)\u3002\u00a0<span class=\"ref-title\">\u65e9\u671f\u6025\u6027\u5fc3\u7b4b\u6897\u585e\u60a3\u800542\u540d\u306b\u304a\u3051\u308b\u8907\u5408\u30c0\u30f3\u30b7\u30a7\u30f3\u70b9\u773c\u85ac\u306e\u6709\u52b9\u6027\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u984e\u3002 J. \u65b0\u85ac<\/em><\/span>\u00a0<span class=\"ref-vol\">18<\/span>\u00a01699 \uff5e 1702 \u5e74\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Chin.+J.+New+Drugs&amp;title=Efficacy+of+compound+danshen+drop+pill+in+42+patients+with+early+acute+myocardial+infarction.&amp;author=L.+I.+Xu-Feng&amp;author=F.+Liu&amp;author=T.+L.+Jiang&amp;author=Z.+J.+Wang&amp;author=Y.+H.+Han&amp;volume=18&amp;publication_year=2010&amp;pages=1699-1702&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google 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role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.+Cell.+Biochem.&amp;title=Breviscapine+protects+against+cardiac+hypertrophy+through+blocking+PKC-alpha-dependent+signaling.&amp;author=L.+Yan&amp;author=H.+Huang&amp;author=Q.+Z.+Tang&amp;author=L.+H.+Zhu&amp;author=L.+Wang&amp;volume=109&amp;publication_year=2010&amp;pages=1158-1171&amp;pmid=20127712&amp;doi=10.1002\/jcb.22495&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B87\"><span class=\"mixed-citation\">\u30e4\u30f3 NR\u3001\u30c1\u30a7\u30f3 QX (2013)\u3002\u00a0<span class=\"ref-title\">PCI\u6cbb\u7652\u5fc3\u7b4b\u6a5f\u80fd\u6539\u5584\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u52b9\u679c\u89b3\u5bdf\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u984e\u3002 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class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Evid.+Based+Complement.+Alternat.+Med.&amp;title=Protective+effects+of+panax+notoginseng+saponins+on+cardiovascular+diseases:+a+comprehensive+overview+of+experimental+studies.&amp;author=X.+Yang&amp;author=X.+Xiong&amp;author=H.+Wang&amp;author=J.+Wang&amp;volume=2014&amp;issue=204840&amp;publication_year=2014&amp;doi=10.1155\/2014\/204840&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B90\"><span class=\"mixed-citation\">Yu H.\u3001Zhang H.\u3001Zhao W.\u3001Guo L.\u3001Li X.\u3001Li Y. \u4ed6\uff082016\u5e74\uff09\u3002\u00a0<span class=\"ref-title\">\u30b8\u30da\u30ce\u30b7\u30c9\u306f\u3001chop \u7d4c\u8def\u306e\u963b\u5bb3\u3068 pi3k\/akt \u7d4c\u8def\u306e\u6d3b\u6027\u5316\u3092\u4ecb\u3057\u3066\u5fc3\u7b4b\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u5fc3\u7b4b\u865a\u8840\u518d\u704c\u6d41\u50b7\u5bb3\u304b\u3089\u4fdd\u8b77\u3057\u307e\u3059\u00a0<em>\u751f\u4f53\u5185<\/em>\u00a0\u305d\u3057\u3066\u00a0<em>\u8a66\u9a13\u7ba1\u5185\u3067<\/em>.<\/span>\u00a0<span class=\"ref-journal\"><em>\u7d30\u80de\u3002\u751f\u7406\u3002\u751f\u5316\u5b66\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">39<\/span>\u00a0123\uff5e136\u3002 10.1159\/000445611 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27322831\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1159%2F000445611\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Cell.+Physiol.+Biochem.&amp;title=Gypenoside+protects+against+myocardial+ischemia-reperfusion+injury+by+inhibiting+cardiomyocytes+apoptosis+via+inhibition+of+chop+pathway+and+activation+of+pi3k\/akt+pathway+in+vivo+and+in+vitro.&amp;author=H.+Yu&amp;author=H.+Zhang&amp;author=W.+Zhao&amp;author=L.+Guo&amp;author=X.+Li&amp;volume=39&amp;publication_year=2016&amp;pages=123-136&amp;pmid=27322831&amp;doi=10.1159\/000445611&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B91\"><span class=\"mixed-citation\">\u3086\u3046 XP (2011)\u3002\u00a0<span class=\"ref-title\">\u9ad8\u8102\u8840\u75c7\u60a3\u8005\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u6ce8\u5c04\u306e\u52b9\u679c\u3068\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u3059\u308b\u7814\u7a76\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u7df4\u7fd2\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u30af\u30ea\u30f3\u3002 \uff2a\uff0e\uff29\uff4e\uff54\uff45\uff47\uff52\uff41\uff54\uff45\uff0e\u4f1d\u7d71\u3002\u984e\u3002\u897f\u3002\u533b\u5b66\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">11<\/span>\u00a020\u301c21\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Pract.+Clin.+J.+Integr.+Tradit.+Chin.+West.+Med.&amp;title=Study+on+effect+of+breviscapine+injection+in+the+treatment+of+patients+with+hyperlipidemia+and+its+mechanism.&amp;author=X.+P.+Yu&amp;volume=11&amp;publication_year=2011&amp;pages=20-21&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B92\"><span class=\"mixed-citation\">\u96f2\u5357\u7701\u30de\u30c6\u30ea\u30a2\u30e1\u30c7\u30a3\u30ab\u7814\u7a76\u6240 (1976)\u3002\u00a0<span class=\"ref-title\">\u306e\u5316\u5b66\u6210\u5206\u306b\u95a2\u3059\u308b\u7814\u7a76\u00a0<em>\u30a8\u30ea\u30b2\u30ed\u30f3\u30fb\u30d6\u30ec\u30d3\u30b9\u30ab\u30d7\u30b9<\/em>.<\/span>\u00a0<span class=\"ref-journal\"><em>\u984e\u3002\u4f1d\u7d71\u3002\u6f22\u65b9\u85ac<\/em><\/span>\u00a0<span class=\"ref-vol\">11<\/span>\u00a011\u301c14\u3002\u96f2\u5357\u7701\u30de\u30c6\u30ea\u30a2\u30e1\u30c7\u30a3\u30ab\u7814\u7a76\u6240\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Chin.+Tradit.+Herbal+Drugs&amp;title=Study+on+the+chemical+constituents+of+Erigeron+breviscapus.&amp;volume=11&amp;publication_year=1976&amp;pages=11-14&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B93\"><span class=\"mixed-citation\">\u5f35 F. (2014)\u3002\u00a0<span class=\"ref-title\">\u99c6\u51fa\u7387\u304c\u6b63\u5e38\u306a\u5fc3\u4e0d\u5168\u60a3\u8005\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u52b9\u679c\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u5e83\u6771\u7701\u5730\u4e2d\u6d77\u3002 J.<\/em><\/span>\u00a0<span class=\"ref-vol\">35<\/span>\u00a03254\uff5e3256\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Guangdong+Med.+J.&amp;title=The+effect+of+breviscapine+on+heart+failure+patients+with+normal+ejection+fraction.&amp;author=F.+Zhang&amp;volume=35&amp;publication_year=2014&amp;pages=3254-3256&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B94\"><span class=\"mixed-citation\">Zhang H.\u3001Wang XY\u3001Liu Y.\u3001Chai LJ\u3001Wang H.\u3001Zhang BL\u3001\u4ed6\u3002 \uff082009\u5e74\uff09\u3002\u00a0<span class=\"ref-title\">\u816b\u760d\u58ca\u6b7b\u56e0\u5b50\u306b\u3088\u3063\u3066\u8a98\u767a\u3055\u308c\u308b\u30e9\u30c3\u30c8\u5fc3\u81d3\u5fae\u5c0f\u8840\u7ba1\u7d30\u80de\u306b\u304a\u3051\u308b\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u7523\u751f\u306b\u5bfe\u3059\u308bDengzhan xixin\u6ce8\u5c04\u306e\u52b9\u679c\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>J. \u30c1\u30f3\u85ac\u5c40\u3002\u79d1\u5b66\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">44<\/span>\u00a01791 \uff5e 1795 \u5e74\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.+Chin.+Pharm.+Sci.&amp;title=Effects+of+dengzhan+xixin+injection+on+inflammatory+cytokine+production+in+rat+cardiac+microvascular+cells+induced+by+tumor+necrosis+factor.&amp;author=H.+Zhang&amp;author=X.+Y.+Wang&amp;author=Y.+Liu&amp;author=L.+J.+Chai&amp;author=H.+Wang&amp;volume=44&amp;publication_year=2009&amp;pages=1791-1795&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B95\"><span class=\"mixed-citation\">\u5f35 QM\u3001\u5f35 FL (2012)\u3002\u00a0<span class=\"ref-title\">\u51a0\u72b6\u52d5\u8108\u6027\u5fc3\u75be\u60a3\u306e\u5fc3\u7b4b\u6897\u585e\u306e\u6cbb\u7642\u306b\u304a\u3051\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u7c89\u672b\u6ce8\u5c04\u306e\u6cbb\u7642\u52b9\u679c\u306b\u95a2\u3059\u308b\u81e8\u5e8a\u89b3\u5bdf\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u5929\u6d25 J. \u30c8\u30e9\u30c7\u30a3\u30c3\u30c8\u3002\u984e\u3002\u533b\u5b66\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">29<\/span>\u00a0133\uff5e135\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Tianjin+J.+Tradit.+Chin.+Med.&amp;title=Clinical+observation+on+the+curative+effect+of+breviscapine+powder+injection+in+treating+heart+stroke+of+coronary+heart+disease.&amp;author=Q.+M.+Zhang&amp;author=F.+L.+Zhang&amp;volume=29&amp;publication_year=2012&amp;pages=133-135&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B96\"><span class=\"mixed-citation\">Zhang RW\u3001Zhang YL\u3001Wang JS\u3001Lin YY\u3001Shang B. (1988)\u3002\u00a0<span class=\"ref-title\">\u30b7\u30e7\u30fc\u30c8\u30b9\u30b1\u30fc\u30d7\u30d2\u30e1\u30d0\u30cd\u304b\u3089\u306e\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306e\u5358\u96e2\u3068\u540c\u5b9a (<em>\u30a8\u30ea\u30b2\u30ed\u30f3\u30fb\u30d6\u30ec\u30d3\u30b9\u30ab\u30d7\u30b9<\/em>).<\/span>\u00a0<span class=\"ref-journal\"><em>\u984e\u3002\u4f1d\u7d71\u3002\u6f22\u65b9\u85ac<\/em><\/span>\u00a0<span class=\"ref-vol\">19<\/span>:<span class=\"ref-iss\">7<\/span>.\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Chin.+Tradit.+Herb+Drugs&amp;title=Isolation+and+identification+of+flavonoids+from+shortscape+fleabane+(Erigeron+breviscapus).&amp;author=R.+W.+Zhang&amp;author=Y.+L.+Zhang&amp;author=J.+S.+Wang&amp;author=Y.+Y.+Lin&amp;author=B.+Shang&amp;volume=19&amp;issue=7&amp;publication_year=1988&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B97\"><span class=\"mixed-citation\">Zhang S.\u3001Liu JY\u3001Zhao L.\u3001Lei K.\u3001Liu Y. (2016)\u3002\u00a0<span class=\"ref-title\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u6ce8\u5c04\u306b\u3088\u308a\u5f15\u304d\u8d77\u3053\u3055\u308c\u305f\u526f\u4f5c\u7528204\u4f8b\u306e\u5206\u6790\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u984e\u3002 J. \u75c5\u9662\u85ac\u5c40\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">36<\/span>\u00a01585 \uff5e 1588 \u5e74\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Chin.+J.+Hosp.+Pharm.&amp;title=Analysis+of+204+cases+of+adverse+drug+reactions+caused+by+breviscapine+injection.&amp;author=S.+Zhang&amp;author=J.+Y.+Liu&amp;author=L.+Zhao&amp;author=K.+Lei&amp;author=Y.+Liu&amp;volume=36&amp;publication_year=2016&amp;pages=1585-1588&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B98\"><span class=\"mixed-citation\">\u5f35 YH (2014)\u3002\u00a0<span class=\"ref-title\">PCI\u5f8c\u306e\u4e3b\u8981\u306a\u5fc3\u8840\u7ba1\u7cfb\u6025\u6027\u5fc3\u7b4b\u6897\u585e\u306b\u5bfe\u3059\u308b\u30e1\u30c8\u30d7\u30ed\u30ed\u30fc\u30eb\u3068\u7d44\u307f\u5408\u308f\u305b\u305fWenxin\u9846\u7c92\u306e\u52b9\u679c\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u984e\u3002 \uff2a\uff0e\uff29\uff4e\uff54\uff45\uff47\uff52\uff41\uff54\uff45\uff0e\u533b\u5b66\u3002\u30ab\u30fc\u30c7\u30a3\u30aa\u30fc\u30eb\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">12<\/span>\u00a0180\uff5e182\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Chin.+J.+Integr.+Med.+Cardiol.&amp;title=Effect+of+Wenxin+Granule+combined+with+metoprolol+on+major+cardiovascular+acute+myocardial+infarction+after+PCI.&amp;author=Y.+H.+Zhang&amp;volume=12&amp;publication_year=2014&amp;pages=180-182&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B99\"><span class=\"mixed-citation\">\u8d99 G. 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(2015)\u3002\u00a0<span class=\"ref-title\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u3068\u30e1\u30b3\u30d0\u30e9\u30df\u30f3\u306b\u3088\u308b\u7cd6\u5c3f\u75c5\u6027\u672b\u68a2\u795e\u7d4c\u969c\u5bb3\u306e\u4f75\u7528\u7642\u6cd5\uff1a\u4e2d\u56fd\u7814\u7a76\u306e\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\u3068\u30e1\u30bf\u5206\u6790\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u30d0\u30a4\u30aa\u30e1\u30c3\u30c9\u3002\u89e3\u50cf\u5ea6\u5185\u90e8\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">2015<\/span>:<span class=\"ref-iss\">680756<\/span>\u00a010.1155\/2015\/680756\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4383387\/\">PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25866802\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1155%2F2015%2F680756\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Biomed.+Res.+Int.&amp;title=Combined+therapy+of+diabetic+peripheral+neuropathy+with+breviscapine+and+mecobalamin:+a+systematic+review+and+a+meta-analysis+of+Chinese+studies.&amp;author=C.+Zheng&amp;author=W.+Ou&amp;author=H.+Shen&amp;author=Z.+Zhou&amp;author=J.+Wang&amp;volume=2015&amp;issue=680756&amp;publication_year=2015&amp;doi=10.1155\/2015\/680756&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B102\"><span class=\"mixed-citation\">Zheng G.\u3001Dong Y.\u3001Liang Y. (1998)\u3002\u00a0<span class=\"ref-title\">\u6458\u51fa\u30e9\u30c3\u30c8\u80f8\u90e8\u5927\u52d5\u8108\u8f2a\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u52b9\u679c\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u984e\u3002\u4f1d\u7d71\u3002\u6f22\u65b9\u85ac<\/em><\/span>\u00a0<span class=\"ref-vol\">10<\/span>\u00a0680\u2013683\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Chin.+Tradit.+Herbal+Drugs&amp;title=Effects+of+breviscapine+on+isolated+rat+thoracic+aortic+ring.&amp;author=G.+Zheng&amp;author=Y.+Dong&amp;author=Y.+Liang&amp;volume=10&amp;publication_year=1998&amp;pages=680-683&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B103\"><span class=\"mixed-citation\">Zhong H.\u3001Deng Y.\u3001Wang X.\u3001Yang B. (2005)\u3002\u00a0<span class=\"ref-title\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u6301\u7d9a\u9001\u9054\u306e\u305f\u3081\u306e\u591a\u5c0f\u80de\u30ea\u30dd\u30bd\u30fc\u30e0\u88fd\u5264\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u5185\u90e8\u3002 \uff2a\uff0e\uff30\uff48\uff41\uff52\uff4d\uff0e<\/em><\/span>\u00a0<span class=\"ref-vol\">301<\/span>\u00a015\u301c24\u3002 10.1016\/j.ijpharm.2005.04.001 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16023316\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1016%2Fj.ijpharm.2005.04.001\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Int.+J.+Pharm.&amp;title=Multivesicular+liposome+formulation+for+the+sustained+delivery+of+breviscapine.&amp;author=H.+Zhong&amp;author=Y.+Deng&amp;author=X.+Wang&amp;author=B.+Yang&amp;volume=301&amp;publication_year=2005&amp;pages=15-24&amp;pmid=16023316&amp;doi=10.1016\/j.ijpharm.2005.04.001&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B104\"><span class=\"mixed-citation\">Zhou H.\u3001Chen X.\u3001Chen L.\u3001Zhou X.\u3001Zheng G.\u3001Zhang H.\u3001\u4ed6\u3002 \uff082014\u5e74\uff09\u3002\u00a0<span class=\"ref-title\">\u30e9\u30c3\u30c8\u306b\u304a\u3051\u308b\u30a4\u30bd\u30d7\u30ec\u30ca\u30ea\u30f3\u8a98\u767a\u5fc3\u7b4b\u7dda\u7dad\u75c7\u306b\u5bfe\u3059\u308b\u30b9\u30af\u30c6\u30e9\u30ea\u30f3\u306e\u5185\u76ae\u9593\u8449\u79fb\u884c\u963b\u5bb3\u306b\u3088\u308b\u6297\u7dda\u7dad\u75c7\u52b9\u679c\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u5206\u5b50<\/em><\/span>\u00a0<span class=\"ref-vol\">19<\/span>\u00a015611 \uff5e 15623\u3002 10.3390\/\u5206\u5b50191015611\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6271942\/\">PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25268717\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.3390%2Fmolecules191015611\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Molecules&amp;title=Anti-fibrosis+effect+of+scutellarin+via+inhibition+of+endothelial-mesenchymal+transition+on+isoprenaline-induced+myocardial+fibrosis+in+rats.&amp;author=H.+Zhou&amp;author=X.+Chen&amp;author=L.+Chen&amp;author=X.+Zhou&amp;author=G.+Zheng&amp;volume=19&amp;publication_year=2014&amp;pages=15611-15623&amp;pmid=25268717&amp;doi=10.3390\/molecules191015611&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B105\"><span class=\"mixed-citation\">\u5468 QS\u3001\u8d99 YM\u3001\u767d X\u3001\u674e PX\u3001\u962e CG (1992)\u3002\u00a0<span class=\"ref-title\">\u30d2\u30c8\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u7dda\u6eb6\u304a\u3088\u3073\u6297\u51dd\u56fa\u306b\u5bfe\u3059\u308b\u65b0\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u52b9\u679c\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u30a2\u30af\u30bf\u30d5\u30a1\u30fc\u30de\u30b3\u30eb\u3002\u7f6a\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">13<\/span>\u00a0239\u2013242\u3002 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/1332421\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Acta+Pharmacol.+Sin.&amp;title=Effect+of+new-breviscapine+on+fibrinolysis+and+anticoagulation+of+human+vascular+endothelial+cells.&amp;author=Q.+S.+Zhou&amp;author=Y.+M.+Zhao&amp;author=X.+Bai&amp;author=P.+X.+Li&amp;author=C.+G.+Ruan&amp;volume=13&amp;publication_year=1992&amp;pages=239-242&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<\/ol>\n<\/div>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#:~:text=A%20meta,2012\">\u30bd\u30fc\u30b9<\/a><\/p>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Breviscapine is a crude extract of several flavonoids of Erigeron breviscapus (Vant.) Hand.-Mazz., containing more than 85% of scutellarin, which has been traditionally used in China as an activating blood circulation medicine to improve cerebral blood supply.<\/p>","protected":false},"author":1,"featured_media":5374,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9],"tags":[],"class_list":["post-5081","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-supplements"],"_links":{"self":[{"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/posts\/5081","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/comments?post=5081"}],"version-history":[{"count":1,"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/posts\/5081\/revisions"}],"predecessor-version":[{"id":5396,"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/posts\/5081\/revisions\/5396"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/media\/5374"}],"wp:attachment":[{"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/media?parent=5081"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/categories?post=5081"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/tags?post=5081"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}