{"id":5171,"date":"2024-01-16T11:01:40","date_gmt":"2024-01-16T11:01:40","guid":{"rendered":"https:\/\/farlong.com\/?p=5171"},"modified":"2024-01-27T10:30:11","modified_gmt":"2024-01-27T10:30:11","slug":"research-progress-on-pyroptosis-mediated-immune-inflammatory-response-in-ischemic-stroke-and-the-role-of-natural-plant-components-as-regulator-of-pyroptosis-a-review","status":"publish","type":"post","link":"https:\/\/directcm.com\/ja\/research-progress-on-pyroptosis-mediated-immune-inflammatory-response-in-ischemic-stroke-and-the-role-of-natural-plant-components-as-regulator-of-pyroptosis-a-review\/","title":{"rendered":"\u865a\u8840\u6027\u8133\u5352\u4e2d\u306b\u304a\u3051\u308b\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u4ecb\u3057\u305f\u514d\u75ab\u708e\u75c7\u53cd\u5fdc\u3068\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u8abf\u7bc0\u56e0\u5b50\u3068\u3057\u3066\u306e\u5929\u7136\u690d\u7269\u6210\u5206\u306e\u5f79\u5272\u306b\u95a2\u3059\u308b\u7814\u7a76\u306e\u9032\u6b69\uff1a\u7dcf\u8aac"},"content":{"rendered":"<div id=\"ab0015\" class=\"abstract author-highlights\">\n<h2 class=\"section-title u-h4 u-margin-l-top u-margin-xs-bottom\">\u30cf\u30a4\u30e9\u30a4\u30c8<\/h2>\n<div id=\"abs0015\">\n<ul>\n<li id=\"p0005\">\u3053\u306e\u7dcf\u8aac\u306f\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u306b\u304a\u3051\u308b\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u6700\u65b0\u306e\u5206\u5b50\u6a5f\u69cb\u3092\u8981\u7d04\u3057\u305f\u3082\u306e\u3067\u3042\u308b\u3002<\/li>\n<li id=\"p0010\">\u3053\u306e\u30ec\u30d3\u30e5\u30fc\u3067\u306f\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u306b\u304a\u3051\u308b\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306e\u8abf\u7bc0\u56e0\u5b50\u3068\u3057\u3066\u306e\u5929\u7136\u690d\u7269\u6210\u5206\u306e\u5f79\u5272\u3092\u307e\u3068\u3081\u3066\u3044\u307e\u3059\u3002<\/li>\n<li id=\"p0015\">\u865a\u8840\u6027\u8133\u5352\u4e2d\u306b\u304a\u3051\u308b\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u5236\u5fa1\u306f\u3001\u6f5c\u5728\u7684\u306a\u6cbb\u7642\u6226\u7565\u3068\u3057\u3066\u63d0\u6848\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div id=\"ab0010\" class=\"abstract author\"><\/p>\n<h2><\/h2>\n<h2 class=\"section-title u-h4 u-margin-l-top u-margin-xs-bottom\">\u62bd\u8c61\u7684\u306a<\/h2>\n<div id=\"abs0010\">\n<p id=\"sp0030\"><a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u865a\u8840\u6027\u8133\u5352\u4e2d\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/brain-ischemia\">\u865a\u8840\u6027\u8133\u5352\u4e2d<\/a>\u00a0(IS) \u306f\u3001\u6b7b\u4ea1\u304a\u3088\u3073\u969c\u5bb3\u306e\u4e3b\u306a\u539f\u56e0\u306e 1 \u3064\u3067\u3059\u3002\u305d\u306e\u75c5\u56e0\u306f\u5b8c\u5168\u306b\u306f\u660e\u3089\u304b\u3067\u306f\u306a\u304f\u3001\u708e\u75c7\u30ab\u30b9\u30b1\u30fc\u30c9\u306f\u305d\u306e\u4e3b\u306a\u539f\u56e0\u306e 1 \u3064\u3067\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u75c5\u7406\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathological-process\">\u75c5\u7406\u5b66\u7684\u30d7\u30ed\u30bb\u30b9<\/a>IS\u306e\u73fe\u5728\u306e\u81e8\u5e8a\u5b9f\u8df5\u306f\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u8840\u6db2\u4f9b\u7d66\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascularity\">\u8840\u6db2\u4f9b\u7d66<\/a>\u00a0IS\u5f8c\u3067\u304d\u308b\u3060\u3051\u65e9\u304f\u865a\u8840\u90e8\u4f4d\u306b\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u8840\u6813\u6eb6\u89e3\u7642\u6cd5\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/fibrinolytic-therapy\">\u8840\u6813\u6eb6\u89e3\u7642\u6cd5<\/a>\u00a0\u8133\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u306f\u3001\u8133\u306e\u795e\u7d4c\u7d30\u80de\u306e\u6d3b\u529b\u3068\u6a5f\u80fd\u3092\u4fdd\u8b77\u3059\u308b\u305f\u3081\u306b\u884c\u308f\u308c\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u8840\u6db2\u306e\u518d\u704c\u6d41\u306b\u3088\u308a\u865a\u8840\u969c\u5bb3\u304c\u3055\u3089\u306b\u4fc3\u9032\u3055\u308c\u3001\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u8133\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u306e\u75c5\u7406\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u306b\u306f\u8907\u6570\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u6b63\u78ba\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u5b8c\u5168\u306b\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyroptosis\">\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9<\/a>\u3001\u65b0\u305f\u306b\u767a\u898b\u3055\u308c\u305f\u708e\u75c7\u6027\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30d7\u30ed\u30b0\u30e9\u30e0\u7d30\u80de\u6b7b\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/programmed-cell-death\">\u30d7\u30ed\u30b0\u30e9\u30e0\u3055\u308c\u305f\u7d30\u80de\u6b7b<\/a>\u306f\u708e\u75c7\u306e\u958b\u59cb\u3068\u9032\u884c\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u708e\u75c7\u8a98\u767a\u6027\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u7d30\u80de\u6b7b\u3067\u3042\u308a\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30ab\u30b9\u30d1\u30fc\u30bc\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/caspase\">\u30ab\u30b9\u30d1\u30fc\u30bc<\/a>\u00a0\u7d30\u80de\u306e\u81a8\u5f35\u3084\u7834\u88c2\u306b\u3064\u306a\u304c\u308b\u30ab\u30b9\u30d1\u30fc\u30bc1\/4\/5\/11\u306f\u3001\u708e\u75c7\u56e0\u5b50IL-1\u03b2\u3068IL-18\u3092\u653e\u51fa\u3057\u3001\u708e\u75c7\u30ab\u30b9\u30b1\u30fc\u30c9\u3092\u8a98\u767a\u3057\u307e\u3059\u3002\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3068\u305d\u308c\u304c\u5a92\u4ecb\u3059\u308b\u708e\u75c7\u53cd\u5fdc\u306f\u865a\u8840\u6027\u8133\u640d\u50b7\u306e\u60aa\u5316\u306e\u91cd\u8981\u306a\u8981\u56e0\u3067\u3042\u308a\u3001\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306e\u963b\u5bb3\u306f\u865a\u8840\u6027\u8133\u640d\u50b7\u3092\u8efd\u6e1b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u7814\u7a76\u3067\u306f\u3001\u5929\u7136\u690d\u7269\u6210\u5206\u304c\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306b\u8abf\u7bc0\u52b9\u679c\u3092\u6301\u3064\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u3053\u306e\u30ec\u30d3\u30e5\u30fc\u3067\u306f\u3001\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u865a\u8840\u6027\u8133\u5352\u4e2d\u306b\u304a\u3051\u308b\u305d\u306e\u5f79\u5272\u3060\u3051\u3067\u306a\u304f\u3001\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306e\u8abf\u7bc0\u56e0\u5b50\u3068\u3057\u3066\u306e\u5929\u7136\u690d\u7269\u6210\u5206\u306e\u5f79\u5272\u3082\u307e\u3068\u3081\u3001\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306b\u95a2\u3059\u308b\u53c2\u8003\u60c5\u5831\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u6cbb\u7642\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/therapeutic-procedure\">\u51e6\u7406<\/a>\u00a0\u5c06\u6765\u306eIS\u306b\u3064\u3044\u3066\u3002<\/p>\n<div class=\"Keywords u-font-serif text-s\">\n<div id=\"keys0005\" class=\"keywords-section\">\n<h2 class=\"section-title u-h4 u-margin-l-top u-margin-xs-bottom\">\u30ad\u30fc\u30ef\u30fc\u30c9<\/h2>\n<div id=\"key0005\" class=\"keyword\">\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3002\u865a\u8840\u6027\u8133\u5352\u4e2d\u3002\u30ab\u30b9\u30d1\u30fc\u30bc;\u5929\u7136\u690d\u7269\u6210\u5206;\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0<\/div>\n<\/div>\n<\/div>\n<div id=\"body\" class=\"Body u-font-serif text-s\">\n<div>\n<section id=\"sec0005\">\n<h2 id=\"sect0025\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">1. \u306f\u3058\u3081\u306b<\/h2>\n<p id=\"p0025\">\u4e16\u754c\u4eba\u53e3\u306e\u9ad8\u9f62\u5316\u306b\u4f34\u3044\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u8133\u8840\u7ba1\u75be\u60a3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebrovascular-disease\">\u8133\u8840\u7ba1\u75be\u60a3<\/a>\u00a0\u8133\u5352\u4e2d\u306a\u3069\u306e\u611f\u67d3\u8005\u6570\u306f\u4e16\u754c\u7b2c2\u4f4d\u3068\u306a\u308a\u3001\u4eba\u985e\u3078\u306e\u8105\u5a01\u306f\u5897\u5927\u3057\u3066\u3044\u308b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib1\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib1\"><span class=\"anchor-text\">[1]<\/span><\/a>\u8133\u5352\u4e2d\u306f\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u865a\u8840\u6027\u8133\u5352\u4e2d\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/brain-ischemia\">\u865a\u8840\u6027\u8133\u5352\u4e2d<\/a>\u00a0\uff08IS\uff09\u3068\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u51fa\u8840\u6027\u8133\u5352\u4e2d\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebral-hemorrhage\">\u51fa\u8840\u6027\u8133\u5352\u4e2d<\/a>\u3001\u8133\u5352\u4e2d\u306e87%\u306f\u865a\u8840\u6027\u3067\u3042\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib2\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib2\"><span class=\"anchor-text\">[2]<\/span><\/a>IS\u306f\u4e00\u822c\u7684\u306a\u81e8\u5e8a\u7684\u7dca\u6025\u4e8b\u614b\u3067\u3042\u308a\u3001\u305d\u306e\u767a\u751f\u7387\u306f\u5e74\u3005\u5897\u52a0\u3057\u3066\u3044\u307e\u3059\u3002IS\u306e\u73fe\u5728\u306e\u81e8\u5e8a\u5b9f\u8df5\u306f\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u8840\u6db2\u4f9b\u7d66\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascularity\">\u8840\u6db2\u4f9b\u7d66<\/a>\u00a0IS\u5f8c\u3067\u304d\u308b\u3060\u3051\u65e9\u304f\u865a\u8840\u90e8\u4f4d\u306b\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u8840\u6813\u6eb6\u89e3\u7642\u6cd5\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/fibrinolytic-therapy\">\u8840\u6813\u6eb6\u89e3\u7642\u6cd5<\/a>\u00a0\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u6d3b\u529b\u3068\u6a5f\u80fd\u3092\u4fdd\u8b77\u3059\u308b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib3\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib3\"><span class=\"anchor-text\">[3]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib4\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib4\"><span class=\"anchor-text\">[4]<\/span><\/a>\u3057\u304b\u3057\u3001\u8840\u6d41\u56de\u5fa9\u5f8c\u306e\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\uff08IRI\uff09\u306f\u3001\u3088\u308a\u6df1\u523b\u306a\u640d\u50b7\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u591a\u3044\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u8133\u7d44\u7e54\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-tissue\">\u8133\u7d44\u7e54<\/a>\u00a0\u3055\u3089\u306b\u3001\u60a3\u8005\u306e\u4e88\u5f8c\u4e0d\u826f\u3084\u6a5f\u80fd\u4e0d\u5168\u3092\u5f15\u304d\u8d77\u3053\u3059\u91cd\u8981\u306a\u8981\u56e0\u3068\u306a\u308a\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib5\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib5\"><span class=\"anchor-text\">[5]<\/span><\/a>\u4e16\u754c\u7684\u306a\u75ab\u5b66\u8abf\u67fb\u3067\u306f\u30011990\u5e74\u304b\u30892019\u5e74\u307e\u3067\u306e\u4e16\u754c\u306e204\u306e\u56fd\u3068\u5730\u57df\u306e\u30c7\u30fc\u30bf\u3092\u5206\u6790\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u5831\u544a\u66f8\u306b\u3088\u308b\u3068\u3001\u8133\u5352\u4e2d\u306f\u4f9d\u7136\u3068\u3057\u3066\u6b7b\u4ea1\u539f\u56e0\u306e\u7b2c2\u4f4d\uff08\u7dcf\u6b7b\u4ea1\u6570\u306e11.6%\uff09\u3001\u6b7b\u4ea1\u3068\u969c\u5bb3\u306e\u7b2c3\u4f4d\uff08\u7dcf\u6b7b\u4ea1\u6570\u306e5.7%\uff09\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u969c\u5bb3\u8abf\u6574\u751f\u5b58\u5e74\u6570\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/disability-adjusted-life-years\">\u969c\u5bb3\u8abf\u6574\u751f\u5b58\u5e74\u6570<\/a>\u00a0(DALYs)]\u306b\u6b21\u30502\u4f4d\u3067\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u65b0\u751f\u5150\u75be\u60a3\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/newborn-disease\">\u65b0\u751f\u5150\u75be\u60a3<\/a>\u00a0(7.3% DALY) \u304a\u3088\u3073\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u865a\u8840\u6027\u5fc3\u75be\u60a3\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemic-heart-disease\">\u865a\u8840\u6027\u5fc3\u75be\u60a3<\/a>\u00a0\uff087.2% DALY\uff09\u3001\u8133\u5352\u4e2d\u60a3\u8005\u6570\u306f\u4f9d\u7136\u3068\u3057\u3066\u5897\u52a0\u3057\u3066\u3044\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib6\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib6\"><span class=\"anchor-text\">[6]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib7\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib7\"><span class=\"anchor-text\">[7]<\/span><\/a>\u7279\u306b\u4e2d\u56fd\u3067\u306f\u3001\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u304c\u4e16\u754c\u3067\u6700\u3082\u9ad8\u3044\u56fd\u3068\u306a\u3063\u3066\u304a\u308a\u3001\u4f4f\u6c11\u306e\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u306f39.3%\u306b\u9054\u3057\u3001\u4e2d\u56fd\u7537\u6027\u306e\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u3082\u4e16\u754c\u3067\u6700\u3082\u9ad8\u304f\u300141%\u3092\u8d85\u3048\u3066\u3044\u307e\u3059\u3002\u4e2d\u56fd\u4f4f\u6c11\u306e\u9593\u3067\u306f\u3001\u8133\u5352\u4e2d\u306f\u7b2c3\u4f4d\uff081990\u5e74\u6642\u70b9\uff09\u304b\u3089\u7b2c1\u4f4d\uff082017\u5e74\u6642\u70b9\uff09\u306b\u4e0a\u6607\u3057\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib8\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib8\"><span class=\"anchor-text\">[8]<\/span><\/a>\u3002\u73fe\u5728\u306e\u7814\u7a76\u3067\u306f\u3001\u8133 IRI (CIRI) \u306e\u75c5\u7406\u5b66\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u4e3b\u306b\u6b21\u306e\u3068\u304a\u308a\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/oxidative-stress\">\u9178\u5316\u30b9\u30c8\u30ec\u30b9<\/a>\u00a0\u3051\u304c\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u708e\u75c7\u6027\u640d\u50b7\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammatory-injury\">\u708e\u75c7\u6027\u640d\u50b7<\/a>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u640d\u50b7\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3001\u305d\u3057\u3066\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/programmed-cell-death\">\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib9\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib9\"><span class=\"anchor-text\">[9]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib10\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib10\"><span class=\"anchor-text\">[10]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib11\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib11\"><span class=\"anchor-text\">[11]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib12\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib12\"><span class=\"anchor-text\">[12]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib13\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib13\"><span class=\"anchor-text\">[13]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib14\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib14\"><span class=\"anchor-text\">[14]<\/span><\/a>\u3002\u3057\u304b\u3057\u3001\u3053\u308c\u3089\u306f\u75c5\u7406\u5b66\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u8aac\u660e\u3059\u308b\u306b\u306f\u307e\u3060\u4e0d\u5341\u5206\u3067\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089 CIRI \u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunoreactive-insulin\">\u30b7\u30ea<\/a>\u4f8b\u3048\u3070\u3001CIRI\u5f8c\u306e\u795e\u7d4c\u7d30\u80de\u6b7b\u306f\u4e3b\u306b\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304a\u308a\u3001\u795e\u7d4c\u7d30\u80de\u4fdd\u8b77\u306e\u65b9\u5411\u306f\u4e3b\u306b\u6297\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306f\u708e\u75c7\u3068\u76f4\u63a5\u95a2\u4fc2\u3057\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib15\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib15\"><span class=\"anchor-text\">[15]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib16\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib16\"><span class=\"anchor-text\">[16]<\/span><\/a>\u3057\u304b\u3057\u3001CIRI\u3067\u306f\u708e\u75c7\u53cd\u5fdc\u304c\u9855\u8457\u3067\u3042\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib16\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib16\"><span class=\"anchor-text\">[16]<\/span><\/a>\u3057\u305f\u304c\u3063\u3066\u3001IS\u306e\u75c5\u614b\u751f\u7406\u5b66\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u3055\u3089\u306b\u660e\u3089\u304b\u306b\u3057\u3001CIRI\u306e\u75c5\u56e0\u3092\u3055\u3089\u306b\u63a2\u7a76\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/p>\n<p id=\"p0030\"><a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyroptosis\">\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9<\/a>\u3001 \u3068\u3057\u3066\u3082\u77e5\u3089\u308c\u3066\u3044\u308b\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u7d30\u80de\u306e\u708e\u75c7\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammatory-cell\">\u7d30\u80de\u708e\u75c7<\/a>\u00a0\u58ca\u6b7b\u306f\u3001\u8fd1\u5e74\u65b0\u305f\u306b\u767a\u898b\u3055\u308c\u78ba\u8a8d\u3055\u308c\u305f\u30d7\u30ed\u30b0\u30e9\u30e0\u7d30\u80de\u6b7b\u3067\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib17\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib17\"><span class=\"anchor-text\">[17]<\/span><\/a>\u3002\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306f\u708e\u75c7\u306b\u4f9d\u5b58\u3057\u3066\u3044\u307e\u3059\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30ab\u30b9\u30d1\u30fc\u30bc\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/caspase\">\u30ab\u30b9\u30d1\u30fc\u30bc<\/a>\u00a0\uff08\u4e3b\u306b\u30ab\u30b9\u30d1\u30fc\u30bc-1\u30014\u30015\u300111\uff09\u305d\u3057\u3066\u591a\u6570\u306e\u708e\u75c7\u4fc3\u9032\u56e0\u5b50\u306e\u653e\u51fa\u3092\u4f34\u3044\u307e\u3059\u3002\u305d\u308c\u306f\u3001\u7d30\u80de\u304c\u6210\u9577\u3059\u308b\u307e\u3067\u7d30\u80de\u304c\u7d99\u7d9a\u7684\u306b\u5897\u6b96\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u73fe\u308c\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u819c\u7834\u88c2\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/membrane-rupture\">\u819c\u7834\u88c2<\/a>\u3001\u7d30\u80de\u5185\u5bb9\u7269\u306e\u653e\u51fa\u3068\u5f37\u3044\u708e\u75c7\u53cd\u5fdc\u306e\u6d3b\u6027\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib17\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib17\"><span class=\"anchor-text\">[17]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib18\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib18\"><span class=\"anchor-text\">[18]<\/span><\/a>\u3002\u306e\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u5f62\u614b\u5b66\u7684\u7279\u5fb4\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/morphological-trait\">\u5f62\u614b\u5b66\u7684\u7279\u5fb4<\/a>\u3001\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u767a\u751f\u3068\u5236\u5fa1\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3084\u30cd\u30af\u30ed\u30fc\u30b7\u30b9\u306a\u3069\u306e\u4ed6\u306e\u7d30\u80de\u6b7b\u65b9\u6cd5\u3068\u306f\u7570\u306a\u308a\u307e\u3059\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib18\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib18\"><span class=\"anchor-text\">[18]<\/span><\/a>\u3002\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306f\u3001\u611f\u67d3\u75c7\u3001\u795e\u7d4c\u7cfb\u95a2\u9023\u75be\u60a3\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u3001\u60aa\u6027\u816b\u760d\u306a\u3069\u306e\u3055\u307e\u3056\u307e\u306a\u75be\u60a3\u306e\u767a\u751f\u3068\u767a\u75c7\u306b\u5e83\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib19\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib19\"><span class=\"anchor-text\">[19]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib20\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib20\"><span class=\"anchor-text\">[20]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib21\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib21\"><span class=\"anchor-text\">[21]<\/span><\/a>\u6700\u65b0\u306e\u7814\u7a76\u3067\u306f\u3001\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3068\u305d\u308c\u304c\u5a92\u4ecb\u3059\u308b\u708e\u75c7\u53cd\u5fdc\u304c\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u75c5\u7406\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathological-process\">\u75c5\u7406\u5b66\u7684\u904e\u7a0b<\/a>\u00a0IS\u306e\u6d3b\u6027\u5316\u3092\u4e88\u9632\u3059\u308b\u3053\u3068\u306f\u708e\u75c7\u30ab\u30b9\u30b1\u30fc\u30c9\u3092\u6291\u5236\u3057\u3001\u865a\u8840\u6027\u8133\u969c\u5bb3\u3092\u8efd\u6e1b\u3059\u308b\u306e\u306b\u6709\u76ca\u3067\u3042\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib22\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib22\"><span class=\"anchor-text\">[22]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib23\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib23\"><span class=\"anchor-text\">[23]<\/span><\/a>\u3002\u3053\u308c\u306b\u57fa\u3065\u3044\u3066\u3001\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u7814\u7a76\u306f\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u6cbb\u7642\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/therapeutic-procedure\">\u51e6\u7406<\/a>\u00a0IS\u306e\u3002\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u5236\u5fa1\u3059\u308b\u3068\u3001IS\u306e\u81f4\u6b7b\u7387\u304c\u4f4e\u4e0b\u3057\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u751f\u5b58\u7387\u304c\u5411\u4e0a\u3057\u3001IS\u60a3\u8005\u306e\u75c7\u72b6\u304c\u6539\u5584\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u73fe\u5728\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u85ac\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chemotherapeutic-agent\">\u85ac\u7269<\/a>\u00a0\u529b\u3092\u767a\u63ee\u3059\u308b\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u795e\u7d4c\u4fdd\u8b77\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroprotective-agent\">\u795e\u7d4c\u4fdd\u8b77<\/a>\u00a0\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u306b\u3088\u308b\u52b9\u679c\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001IS \u306b\u304a\u3051\u308b\u8840\u7ba1\u30cb\u30e5\u30fc\u30ed\u30f3\u5358\u4f4d\u306e\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u5236\u5fa1\u3059\u308b\u5929\u7136\u690d\u7269\u6210\u5206\u306b\u95a2\u3059\u308b\u7814\u7a76\u304c\u6570\u591a\u304f\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u306e\u4ee5\u524d\u306e\u7814\u7a76\u3067\u3082\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30b5\u30dd\u30cb\u30f3\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/saponin\">\u30b5\u30dd\u30cb\u30f3<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib24\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib24\"><span class=\"anchor-text\">[24]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib25\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib25\"><span class=\"anchor-text\">[25]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib26\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib26\"><span class=\"anchor-text\">[26]<\/span><\/a>\u00a0\u304a\u3088\u3073\u591a\u6210\u5206\u5316\u5408\u7269\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib27\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib27\"><span class=\"anchor-text\">[27]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib28\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib28\"><span class=\"anchor-text\">[28]<\/span><\/a>\u00a0\u898f\u5236\u3067\u304d\u308b\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u751f\u7269\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/biological-phenomena-and-functions-concerning-the-entire-organism\">\u751f\u7269\u5b66\u7684\u30d7\u30ed\u30bb\u30b9<\/a>\u00a0IS \u306b\u304a\u3051\u308b\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306e\u767a\u73fe\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u3053\u306e\u30ec\u30d3\u30e5\u30fc\u3067\u306f\u3001\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u865a\u8840\u6027\u8133\u5352\u4e2d\u306b\u304a\u3051\u308b\u305d\u306e\u5f79\u5272\u3092\u307e\u3068\u3081\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u5c06\u6765\u306e\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u95a2\u9023\u85ac\u5264\u958b\u767a\u306e\u305f\u3081\u306e\u30ea\u30fc\u30c9\u5316\u5408\u7269\u307e\u305f\u306f\u5929\u7136\u690d\u7269\u6210\u5206\u3092\u63d0\u4f9b\u3059\u308b\u305f\u3081\u306b\u3001\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306e\u8abf\u7bc0\u56e0\u5b50\u3068\u3057\u3066\u306e\u5929\u7136\u690d\u7269\u6210\u5206\u306e\u5f79\u5272\u306b\u3064\u3044\u3066\u3082\u307e\u3068\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/section>\n<section id=\"sec0010\">\n<h2 id=\"sect0030\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">2. \u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9<\/h2>\n<section id=\"sec0015\">\n<h3 id=\"sect0035\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.1. \u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306e\u7279\u5fb4<\/h3>\n<div>\n<p id=\"p0035\"><a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyroptosis\">\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9<\/a>\u00a0\u306f\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30d7\u30ed\u30b0\u30e9\u30e0\u7d30\u80de\u6b7b\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/programmed-cell-death\">\u30d7\u30ed\u30b0\u30e9\u30e0\u3055\u308c\u305f\u7d30\u80de\u6b7b<\/a>\u00a0\u708e\u75c7\u8a98\u767a\u6027\u7269\u8cea\u306b\u4f9d\u5b58\u3059\u308b\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30ab\u30b9\u30d1\u30fc\u30bc\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/caspase\">\u30ab\u30b9\u30d1\u30fc\u30bc<\/a>\u819c\u8cab\u901a\u5b54\u306e\u5f62\u6210\u3001\u7d30\u80de\u819c\u306e\u81a8\u5f35\u3068\u7834\u88c2\u3001\u708e\u75c7\u8a98\u767a\u6027\u5185\u5bb9\u7269\u306e\u653e\u51fa\u3092\u7279\u5fb4\u3068\u3059\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib29\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib29\"><span class=\"anchor-text\">[29]<\/span><\/a>\u3002\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u904e\u7a0b\u3067\u306f\u3001\u7d30\u80de\u306f\u6838\u306e\u65ad\u7247\u5316\u3068\u7d30\u80de\u819c\u306e\u5b8c\u5168\u6027\u3092\u6301\u3061\u3001\u5468\u56f2\u306e\u7d44\u7e54\u306b\u708e\u75c7\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u305b\u3093\u304c\u3001\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u904e\u7a0b\u3067\u306f\u7d30\u80de\u306f\u5b8c\u5168\u306a\u6838\u306e\u5f62\u614b\u3068\u7d30\u80de\u3092\u6301\u3061\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u819c\u7834\u88c2\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/membrane-rupture\">\u819c\u7834\u88c2<\/a>\u3001\u672b\u68a2\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib30\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib30\"><span class=\"anchor-text\">[30]<\/span><\/a>\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u304c\u8d77\u3053\u308b\u3068\u3001\u7d30\u80de\u819c\u304c\u5f90\u3005\u306b\u7834\u308c\u30661\uff5e2nm\u306e\u7d30\u80de\u819c\u5b54\u304c\u5f62\u6210\u3055\u308c\u3001\u7d30\u80de\u5185\u306e\u708e\u75c7\u56e0\u5b50\u306a\u3069\u306e\u7d30\u80de\u5185\u5bb9\u7269\u304c\u7d30\u80de\u819c\u5916\u306b\u653e\u51fa\u3055\u308c\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30a8\u30c1\u30b8\u30a6\u30e0\u30d6\u30ed\u30de\u30a4\u30c9\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ethidium-bromide\">\u81ed\u5316\u30a8\u30c1\u30b8\u30a6\u30e0<\/a>\u00a0\u7d30\u80de\u304c\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3092\u8d77\u3053\u3059\u304b\u3069\u3046\u304b\u3092\u89b3\u5bdf\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3067\u304d\u308b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib31\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib31\"><span class=\"anchor-text\">[31]<\/span><\/a>\u3002\u3055\u3089\u306b\u3001\u58ca\u6b7b\u306e\u767a\u751f\u306f\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\u69d8\u306e\u6df7\u5408\u7cfb\u5217\u306b\u4f9d\u5b58\u3057\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30c9\u30e1\u30a4\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/protein-domain\">\u30c9\u30e1\u30a4\u30f3\u30bf\u30f3\u30d1\u30af\u8cea<\/a>\u00a0(MLKL)\u3001\u7d30\u80de\u306b\u5165\u308b\u30a4\u30aa\u30f3\u306b\u5bfe\u3057\u3066\u9078\u629e\u7684\u3067\u3042\u308a\u3001\u6838\u30af\u30ed\u30de\u30c1\u30f3\u306f\u51dd\u96c6\u6027\u307e\u305f\u306f\u7aef\u306b\u51dd\u96c6\u3057\u3066\u3044\u307e\u3059\u3002\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306f\u3001\u6838\u5206\u88c2\u3092\u5f15\u304d\u8d77\u3053\u3059\u975e\u9078\u629e\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u5b54\u5f62\u6210\u30bf\u30f3\u30d1\u30af\u8cea GSDMD \u306b\u4f9d\u5b58\u3057\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u3001\u30d4\u30af\u30ce\u30fc\u30b7\u30b9\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyknosis\">\u30d4\u30af\u30ce\u30b7\u30b9<\/a>\u00a0\u305d\u3057\u3066\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089DNA\u65ad\u7247\u5316\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/dna-fragmentation\">DNA\u306e\u65ad\u7247\u5316<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib32\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib32\"><span class=\"anchor-text\">[32]<\/span><\/a>\u3002\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3001\u30cd\u30af\u30ed\u30c8\u30fc\u30b7\u30b9\u3001\u304a\u3088\u3073\u30cd\u30af\u30ed\u30c8\u30fc\u30b7\u30b9\u306b\u306f\u985e\u4f3c\u70b9\u3068\u76f8\u9055\u70b9\u304c\u3042\u308a\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30d5\u30a7\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ferroptosis\">\u30d5\u30a7\u30ed\u30c8\u30fc\u30b7\u30b9<\/a>\u539f\u56e0\u3084\u7d30\u80de\u306e\u5909\u5316\u306a\u3069\u3002\u8a73\u7d30\u306f\u3001\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#tbl0005\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"tbl0005\"><span class=\"anchor-text\">\u88681<\/span><\/a>.<\/p>\n<div id=\"tbl0005\" class=\"tables colsep-0 rowsep-0 frame-topbot\">\n<p id=\"sp0020\"><span class=\"label\">\u88681<\/span>\u3002\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3001\u30cd\u30af\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u985e\u4f3c\u70b9\u3068\u76f8\u9055\u70b9\u3002<\/p>\n<div class=\"groups\">\n<table>\n<thead>\n<tr class=\"rowsep-1\">\n<th scope=\"col\">\u7279\u5fb4<\/th>\n<th scope=\"col\">\u7279\u5fb4\u7684\u306a\u30b3\u30f3\u30dd\u30fc\u30cd\u30f3\u30c8<\/th>\n<th scope=\"col\">\u7d30\u80de\u306e\u5909\u5316<\/th>\n<th scope=\"col\">\u4e00\u822c\u7684\u306a\u539f\u56e0<\/th>\n<th scope=\"col\">\u963b\u5bb3\u5264<\/th>\n<th scope=\"col\">\u53c2\u7167<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<th scope=\"row\">\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9<\/th>\n<td>\u30d4\u30ed\u30d7\u30c8\u30bd\u30fc\u30e0\u3001\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0<\/td>\n<td>\u5b54\u5f62\u6210\u3001\u7d30\u80de\u81a8\u5f35\u3001\u7d30\u80de\u819c\u7834\u88c2\u3001\u30af\u30ed\u30de\u30c1\u30f3\u51dd\u7e2e\u3001DNA\u65ad\u7247\u5316\u3001\u6838\u306e\u5b8c\u5168\u6027\u306a\u3069\u3002<\/td>\n<td>DAMP\u3001PAMP\u3001\u611f\u67d3\u75c7<\/td>\n<td>GSDMD\u963b\u5bb3\u5264<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib19\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib19\"><span class=\"anchor-text\">[19]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib33\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib33\"><span class=\"anchor-text\">[33]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib34\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib34\"><span class=\"anchor-text\">[34]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib35\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib35\"><span class=\"anchor-text\">[35]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib36\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib36\"><span class=\"anchor-text\">[36]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9<\/th>\n<td>\u30a2\u30dd\u30c8\u30bd\u30fc\u30e0<\/td>\n<td>\u7d30\u80de\u306f\u7121\u50b7\u306e\u819c\u3001\u7d30\u80de\u819c\u306e\u6c34\u75b1\u5f62\u6210\u3001\u30af\u30ed\u30de\u30c1\u30f3\u51dd\u7e2e\u3001DNA \u65ad\u7247\u5316\u306a\u3069\u3092\u4f34\u3063\u3066\u7e2e\u5c0f\u3057\u307e\u3059\u3002<\/td>\n<td>\u751f\u7406\u5b66\u7684\u72b6\u614b\u306e\u907a\u4f1d\u5b50\u5236\u5fa1<\/td>\n<td>\u30ab\u30b9\u30d1\u30fc\u30bc\u30d5\u30a1\u30df\u30ea\u30fc\u3001Bcl-2\u30d5\u30a1\u30df\u30ea\u30fc\u3001p53\u306a\u3069\u306e\u8abf\u7bc0\u3002<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib37\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib37\"><span class=\"anchor-text\">[37]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib38\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib38\"><span class=\"anchor-text\">[38]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib39\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib39\"><span class=\"anchor-text\">[39]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u30cd\u30af\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9<\/th>\n<td>\u30cd\u30af\u30ed\u30bd\u30fc\u30e0<\/td>\n<td>\u7d30\u80de\u306e\u81a8\u5f35\u3001\u7d30\u80de\u819c\u306e\u7834\u88c2\u3001\u7d30\u80de\u5c0f\u5668\u5b98\u306e\u81a8\u5f35\u3001\u30af\u30ed\u30de\u30c1\u30f3\u306e\u51dd\u7e2e\u306a\u3069\u3002<\/td>\n<td>\u91cd\u50b7<\/td>\n<td>Nec-1\u3001NSA\u306a\u3069<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib33\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib33\"><span class=\"anchor-text\">[33]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib40\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib40\"><span class=\"anchor-text\">[40]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib41\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib41\"><span class=\"anchor-text\">[41]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib42\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib42\"><span class=\"anchor-text\">[42]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib43\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib43\"><span class=\"anchor-text\">[43]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u30d5\u30a7\u30ed\u30c8\u30fc\u30b7\u30b9<\/th>\n<td>NRF2\u3001GPX4\u3001ACSL4\u306a\u3069<\/td>\n<td>\u4e3b\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u767a\u751f\u3057\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30af\u30ea\u30b9\u30c6\u304c\u6e1b\u5c11\u3057\u3001\u819c\u304c\u51dd\u7e2e\u3057\u3001\u5916\u819c\u304c\u7834\u88c2\u3057\u307e\u3059\u3002<\/td>\n<td>Fe2 + \u904e\u8ca0\u8377\u3068 ROS<\/td>\n<td>GSH\u3001\u30c7\u30d5\u30a7\u30ed\u30ad\u30b5\u30df\u30f3\u3001\u30ea\u30d7\u30ed\u30b9\u30bf\u30c1\u30f3-1\u3001\u30d5\u30a7\u30ed\u30b9\u30bf\u30c1\u30f3-1\u306a\u3069<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib44\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib44\"><span class=\"anchor-text\">[44]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib45\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib45\"><span class=\"anchor-text\">[45]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib46\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib46\"><span class=\"anchor-text\">[46]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib47\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib47\"><span class=\"anchor-text\">[47]<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section id=\"sec0020\">\n<h3 id=\"sect0040\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.2.\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u5206\u5b50\u6a5f\u69cb<\/h3>\n<p id=\"p0040\">\u306e\u5f62\u6210\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammasome\">\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0<\/a>\u00a0\u306f\u3001\u640d\u50b7\u5f8c\u306e\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306e\u91cd\u8981\u306a\u7269\u8cea\u3067\u3059\u3002\u640d\u50b7\u3092\u53d7\u3051\u305f\u5834\u5408\u3001\u4f53\u306f\u75c5\u539f\u4f53\u95a2\u9023\u5206\u5b50\u30d1\u30bf\u30fc\u30f3\uff08PAMP\uff09\u3068\u640d\u50b7\u95a2\u9023\u5206\u5b50\u30d1\u30bf\u30fc\u30f3\uff08DAMP\uff09\u306b\u95a2\u9023\u3059\u308b\u30d1\u30bf\u30fc\u30f3\u4fe1\u53f7\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib48\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib48\"><span class=\"anchor-text\">[48]<\/span><\/a>\u3002\u4fe1\u53f7\u523a\u6fc0\u304c\u8d77\u3053\u308b\u3068\u3001\u7d30\u80de\u5185\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc \u30bf\u30f3\u30d1\u30af\u8cea\u306e\u8a73\u7d30\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/promoter-protein\">\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u30bf\u30f3\u30d1\u30af\u8cea<\/a>\u00a0\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u7d50\u5408\u30aa\u30ea\u30b4\u30de\u30fc\u5316\u30c9\u30e1\u30a4\u30f3\u69d8\u53d7\u5bb9\u4f53\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089 pyrin \u30c9\u30e1\u30a4\u30f3\u306e\u8a73\u7d30\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyrin-domain\">\u30d4\u30ea\u30f3\u30c9\u30e1\u30a4\u30f3<\/a>\u00a03 (NLRP3) \u3092\u542b\u3080\u3082\u306e\u306f\u3001\u30aa\u30ea\u30b4\u30de\u30fc\u5316\u3092\u901a\u3058\u3066\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u30a2\u30c0\u30d7\u30bf\u30fc\u5206\u5b50 ASC \u3092\u4f7f\u7528\u3057\u3066\u5927\u91cf\u306e\u30d7\u30ed\u30ab\u30b9\u30d1\u30fc\u30bc 1 \u3092\u52d5\u54e1\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib49\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib49\"><span class=\"anchor-text\">[49]<\/span><\/a>\u3001\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u51dd\u96c6\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5f62\u6210\u3002\u30d7\u30ed\u30ab\u30b9\u30d1\u30fc\u30bc-1 \u306f\u30ab\u30b9\u30d1\u30fc\u30bc-1 \u306e\u524d\u99c6\u4f53\u3067\u3042\u308a\u3001\u901a\u5e38\u3001\u30d7\u30ed\u30ab\u30b9\u30d1\u30fc\u30bc-1 \u306f\u6b21\u306e\u3088\u3046\u306a\u5f62\u3067\u4f53\u5185\u306b\u5b58\u5728\u3057\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30c1\u30e2\u30fc\u30b2\u30f3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/enzyme-precursor\">\u30c1\u30e2\u30fc\u30b2\u30f3<\/a>\u3002\u523a\u6fc0\u30b7\u30b0\u30ca\u30eb\u304c\u30d7\u30ed\u30ab\u30b9\u30d1\u30fc\u30bc 1 \u306b\u4f1d\u9054\u3055\u308c\u308b\u3068\u3001\u81ea\u5df1\u52a0\u6c34\u5206\u89e3\u306b\u3088\u3063\u3066 P20 \u304a\u3088\u3073 P10 \u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u304c\u751f\u6210\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306f\u6700\u521d\u306b\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30d8\u30c6\u30ed\u4e8c\u91cf\u4f53\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/heterodimer\">\u30d8\u30c6\u30ed\u4e8c\u91cf\u4f53<\/a>\u00a0\u305d\u308c\u306f\u6a5f\u80fd\u3067\u304d\u305a\u3001\u96c6\u5408\u3057\u3066\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u56db\u91cf\u4f53\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tetramer\">\u56db\u91cf\u4f53<\/a>\u00a0\u30ab\u30b9\u30d1\u30fc\u30bc1\u306e\u6d3b\u6027\u3092\u4fc3\u9032\u3057\u3001\u30ab\u30b9\u30d1\u30fc\u30bc1\u306e\u6d3b\u6027\u5316\u306b\u3064\u306a\u304c\u308b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib50\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib50\"><span class=\"anchor-text\">[50]<\/span><\/a>\u30ab\u30b9\u30d1\u30fc\u30bc1\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b\u3068\u3001\u6d3b\u6027\u30ab\u30b9\u30d1\u30fc\u30bc1\u306f\u7d30\u80de\u819c\u306e\u5b54\u306e\u5f62\u6210\u3068\u7d30\u80de\u819c\u306e\u6025\u901f\u306a\u6eb6\u89e3\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u708e\u75c7\u53cd\u5fdc\u3092\u5f62\u6210\u3057\u307e\u3059\u3002\u4e00\u65b9\u3001\u30ab\u30b9\u30d1\u30fc\u30bc1\u306fIL-1\u03b2\u3068IL-18\u306e\u524d\u99c6\u4f53\u3067\u3042\u308b\u30d7\u30edIL-1\u03b2\u3068\u30d7\u30edIL-18\u3092\u8a98\u5c0e\u3057\u3066\u6210\u719f\u30d7\u30ed\u30bb\u30b9\u3092\u52a0\u901f\u3055\u305b\u308b\u3053\u3068\u3082\u3067\u304d\u307e\u3059\u3002\u6210\u719f\u3057\u305fIL-1\u03b2\u3068IL-18\u306f\u7d30\u80de\u5916\u306b\u653e\u51fa\u3055\u308c\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u3088\u308a\u591a\u304f\u306e\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u3092\u30ea\u30af\u30eb\u30fc\u30c8\u3057\u307e\u3059\u3002\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u304c\u51dd\u96c6\u3059\u308b\u3068\u3001\u708e\u75c7\u53cd\u5fdc\u304c\u3055\u3089\u306b\u60aa\u5316\u3057\u3001\u7d44\u7e54\u640d\u50b7\u304c\u60aa\u5316\u3057\u307e\u3059\u3002IL-1\u03b2\u304c\u7d30\u80de\u304b\u3089\u653e\u51fa\u3055\u308c\u308b\u3068\u3001\u708e\u75c7\u56e0\u5b50\u306f\u30ea\u30f3\u30d1\u306e\u6d41\u308c\u306b\u6cbf\u3063\u3066\u96a3\u63a5\u7d44\u7e54\u306b\u5e83\u304c\u308a\u3001\u708e\u75c7\u53cd\u5fdc\u3092\u3055\u3089\u306b\u60aa\u5316\u3055\u305b\u307e\u3059\u3002\u5927\u91cf\u306eIL-18\u306e\u5206\u6ccc\u306fTh1\u3068Th2\u306e\u514d\u75ab\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u514d\u75ab\u53cd\u5fdc\u3092\u523a\u6fc0\u3057\u3066\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib51\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib51\"><span class=\"anchor-text\">[51]<\/span><\/a>.<\/p>\n<section id=\"sec0025\">\n<h4 id=\"sect0045\" class=\"u-margin-m-top u-margin-xs-bottom\">2.2.1.\u6b63\u898f\u306e\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def<\/h4>\n<p id=\"p0045\">\u30ab\u30b9\u30d1\u30fc\u30bc-1 \u306f\u6a19\u6e96\u7684\u306a\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306f\u30ab\u30b9\u30d1\u30fc\u30bc-1 \u306e\u6d3b\u6027\u5316\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib52\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib52\"><span class=\"anchor-text\">[52]<\/span><\/a>\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306f\u81ea\u7136\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u91cd\u8981\u306a\u90e8\u5206\u3067\u3042\u308a\u3001\u30bb\u30f3\u30b5\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3001ASC\u3001\u30d7\u30ed\u30ab\u30b9\u30d1\u30fc\u30bc1\u304b\u3089\u306a\u308b\u591a\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u3067\u3059\u3002\u523a\u6fc0\u3092\u53d7\u3051\u305f\u7d30\u80de\u306e\u7d30\u80de\u8cea\u306b\u5b58\u5728\u3057\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u514d\u75ab\u7d30\u80de\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunocompetent-cell\">\u514d\u75ab\u7d30\u80de<\/a>\u00a0\u7d30\u80de\u5916\u523a\u6fc0\u4fe1\u53f7\u3092\u611f\u77e5\u3067\u304d\u308b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib53\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib53\"><span class=\"anchor-text\">[53]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib54\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib54\"><span class=\"anchor-text\">[54]<\/span><\/a>\u3002\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306f\u3001\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u7d50\u5408\u30aa\u30ea\u30b4\u30de\u30fc\u5316\u30c9\u30e1\u30a4\u30f3\u69d8\u53d7\u5bb9\u4f53 (NLR) \u3092\u542b\u3080\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306b\u5206\u985e\u3055\u308c\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u9ed2\u8272\u816b\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nodular-melanoma\">\u9ed2\u8272\u816b<\/a>\u00a02 (AIM2) \u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u304a\u3088\u3073 NLRC4 \u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib55\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib55\"><span class=\"anchor-text\">[55]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib56\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib56\"><span class=\"anchor-text\">[56]<\/span><\/a>\u3002\u30d7\u30ea\u30f3\u4f5c\u52d5\u6027 2 \u00d7 7 (P2X7) \u53d7\u5bb9\u4f53\u306f\u3001ATP \u4f9d\u5b58\u6027\u819c\u8cab\u901a\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u53d7\u5bb9\u4f53\u3067\u3042\u308a\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microglia\">\u30df\u30af\u30ed\u30b0\u30ea\u30a2<\/a>\u00a0\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u6d3b\u6027\u5316\u306e\u91cd\u8981\u306a\u8981\u7d20\u3067\u3059\u3002\u7814\u7a76\u3067\u306f\u3001\u7d30\u80de\u5916ATP\u304cK+\u306e\u6392\u51fa\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u8abf\u7bc0\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089 P2X7 \u53d7\u5bb9\u4f53\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/purinergic-p2x7-receptor\">P2X7\u53d7\u5bb9\u4f53<\/a>\u3001NLR \u30d5\u30a1\u30df\u30ea\u30fc\u3001\u30d4\u30ea\u30f3\u30c9\u30e1\u30a4\u30f3\u542b\u6709 3 (NLRP3) \u306e\u6d3b\u6027\u5316\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib57\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib57\"><span class=\"anchor-text\">[57]<\/span><\/a>NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306f\u73fe\u5728\u6700\u3082\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u3002NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u6d3b\u6027\u5316\u306b\u306f2\u6bb5\u968e\u306e\u53cd\u5fdc\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002\u53cd\u5fdc\u306e\u958b\u59cb\u3001\u5fae\u751f\u7269\u307e\u305f\u306f\u5185\u56e0\u6027\u56e0\u5b50\u3067\u3042\u308b\u6838\u56e0\u5b50\u03baB\uff08NF-\u03baB\uff09\u306e\u6838\u5185\u3078\u306e\u4fb5\u5165\u3001\u304a\u3088\u3073NLRP3\u304a\u3088\u3073\u30d7\u30edIL-1\u03b2\u767a\u73fe\u306e\u4e0a\u6607\u3067\u3042\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib58\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib58\"><span class=\"anchor-text\">[58]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib59\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib59\"><span class=\"anchor-text\">[59]<\/span><\/a>\u3002\u514d\u75ab\u7d30\u80de\u304c DAMP \u306b\u3088\u3063\u3066\u523a\u6fc0\u3055\u308c\u308b\u3068\u3001\u30bb\u30f3\u30b5\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u304c ASC \u3092\u4ecb\u3057\u3066\u30d7\u30ed\u30ab\u30b9\u30d1\u30fc\u30bc 1 \u3092\u88dc\u5145\u3057\u3001\u305d\u306e\u5f8c\u3001\u81ea\u5df1\u52a0\u6c34\u5206\u89e3\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3055\u308c\u307e\u3059\u3002\u6210\u719f\u30ab\u30b9\u30d1\u30fc\u30bc-1 \u306f\u3001\u4e0b\u6d41\u3067\u4e0d\u6d3b\u6027\u306a\u30d7\u30ed IL-1\u03b2 \u304a\u3088\u3073\u30d7\u30ed IL-18 \u3092\u6d3b\u6027\u578b IL-1\u03b2 \u304a\u3088\u3073 IL-18 \u306b\u30d7\u30ed\u30bb\u30b9\u3057\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib60\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib60\"><span class=\"anchor-text\">[60]<\/span><\/a>\u3002\u4e00\u65b9\u3001Caspase-1 \u306f\u3001\u7d30\u5b54\u5f62\u6210\u6d3b\u6027\u306b\u3088\u308a\u4e0b\u6d41\u306e GSDMD \u30bf\u30f3\u30d1\u30af\u8cea\u3092 GSDMD-N \u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u3068 GSDMD-C \u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u306b\u5207\u65ad\u3057\u307e\u3059\u3002 GSDMD-N \u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u306f\u3001\u7279\u7570\u7684\u306b\u8a8d\u8b58\u3057\u3066\u7d50\u5408\u3057\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u819c\u8102\u8cea\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/membrane-lipid\">\u819c\u8102\u8cea<\/a>\u00a0\u7d30\u80de\u819c\u306e\u5185\u5074\u3067\u3001\u7d30\u80de\u5185\u5916\u306e\u6d78\u900f\u5727\u306e\u5909\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u7d30\u80de\u306e\u81a8\u5f35\u3068\u7834\u88c2\u3001\u708e\u75c7\u56e0\u5b50IL-1\u03b2\u3068IL-18\u306e\u653e\u51fa\u306b\u3064\u306a\u304c\u308a\u3001\u708e\u75c7\u53cd\u5fdc\u3068\u7d30\u80de\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u767a\u3057\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib61\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib61\"><span class=\"anchor-text\">[61]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0030\">\n<h4 id=\"sect0050\" class=\"u-margin-m-top u-margin-xs-bottom\">2.2.2. \u975e\u6a19\u6e96\u7684\u306a\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def<\/h4>\n<p id=\"p0050\">\u30ab\u30b9\u30d1\u30fc\u30bc\u30d5\u30a1\u30df\u30ea\u30fc\u306f\u3001\u7570\u306a\u308b\u6a5f\u80fd\u306b\u5fdc\u3058\u3066\u4e3b\u306b\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u95a2\u9023\u3068\u708e\u75c7\u95a2\u9023\u306e 2 \u3064\u306e\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u5206\u985e\u3055\u308c\u307e\u3059\u3002\u30ab\u30b9\u30d1\u30fc\u30bc-3\/2\/10 \u306f\u4e3b\u306b\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u5a92\u4ecb\u3057\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-1\/4\/5\/11 \u306f\u708e\u75c7\u3068\u81ea\u7136\u514d\u75ab\u5fdc\u7b54\u306e\u91cd\u8981\u306a\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u3067\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib62\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib62\"><span class=\"anchor-text\">[62]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib63\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib63\"><span class=\"anchor-text\">[63]<\/span><\/a>\u975e\u6a19\u6e96\u7684\u306a\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u306f\u30ab\u30b9\u30d1\u30fc\u30bc4\/5\/11\u306e\u6d3b\u6027\u5316\u306b\u4f9d\u5b58\u3057\u3066\u3044\u308b\u304c\u3001\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306fIL-1\u03b2\u3068IL-18\u306e\u6210\u719f\u306b\u306f\u5fc5\u9808\u3067\u306f\u306a\u3044\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib64\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib64\"><span class=\"anchor-text\">[64]<\/span><\/a>\u3002\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u975e\u53e4\u5178\u7684\u7d4c\u8def\u306f\u4ee5\u4e0b\u306b\u3088\u3063\u3066\u8a98\u767a\u3055\u308c\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30ea\u30dd\u591a\u7cd6\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/lipopolysaccharide\">\u30ea\u30dd\u591a\u7cd6\u985e<\/a>\u00a0\u30b0\u30e9\u30e0\u9670\u6027\u7d30\u83cc\u306e\u7d30\u80de\u58c1\u6210\u5206\u3067\u3042\u308bLPS\u3002LPS\u306f\u30d2\u30c8\u30ab\u30b9\u30d1\u30fc\u30bc4\/5\u3068\u30de\u30a6\u30b9\u30ab\u30b9\u30d1\u30fc\u30bc11\u306b\u76f4\u63a5\u7d50\u5408\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u3053\u308c\u3089\u306e\u30ab\u30b9\u30d1\u30fc\u30bc\u306fLPS\u306e\u30bb\u30f3\u30b5\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u5206\u5b50\u306e\u4e21\u65b9\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3002\u6d3b\u6027\u5316\u3055\u308c\u305f\u30ab\u30b9\u30d1\u30fc\u30bc4\/5\/11\u306fGSDMD\u3092\u76f4\u63a5\u5207\u65ad\u3057\u3001\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u5c0e\u3059\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib65\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib65\"><span class=\"anchor-text\">[65]<\/span><\/a>\u3002\u3055\u3089\u306b\u3001\u30ab\u30b9\u30d1\u30fc\u30bc 11 \u304c\u4e0b\u6d41\u306e\u7d30\u80de\u3092\u6d3b\u6027\u5316\u3067\u304d\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30ae\u30e3\u30c3\u30d7\u30b8\u30e3\u30f3\u30af\u30b7\u30e7\u30f3\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/gap-junction\">\u30ae\u30e3\u30c3\u30d7\u30b8\u30e3\u30f3\u30af\u30b7\u30e7\u30f3<\/a>\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30c1\u30e3\u30cd\u30eb \u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/channel-protein\">\u30c1\u30e3\u30cd\u30eb\u30bf\u30f3\u30d1\u30af\u8cea<\/a>\u00a0Pannexin-1\u306fK+\u6392\u51fa\u3092\u4fc3\u9032\u3057\u3001K+\u6392\u51fa\u306fNLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u3092\u6d3b\u6027\u5316\u3057\u3001\u305d\u308c\u304c\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3092\u6d3b\u6027\u5316\u3057\u3001IL-1\u03b2\u3068IL-18\u306e\u6210\u719f\u3092\u4fc3\u9032\u3059\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib66\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib66\"><span class=\"anchor-text\">[66]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0035\">\n<h4 id=\"sect0055\" class=\"u-margin-m-top u-margin-xs-bottom\">2.2.3. GSDMD\u3068\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306e\u95a2\u4fc2<\/h4>\n<p id=\"p0055\">GSDMD (Gsdermin D) \u306f\u3001484 \u500b\u306e\u30a2\u30df\u30ce\u9178\u6b8b\u57fa\u65ad\u7247\u304b\u3089\u306a\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3001Gasdermin \u30bf\u30f3\u30d1\u30af\u8cea\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u30e1\u30f3\u30d0\u30fc\u3067\u3059\u3002\u3053\u306e\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u306f\u4e3b\u306b 5 \u3064\u306e\u30e1\u30f3\u30d0\u30fc\u304c\u3042\u308a\u3001DFNA5\u3001DFNB59\u3001GSDMA\u3001GSDMB\u3001GSDMCD \u3067\u3059\u3002\u3053\u308c\u3089 5 \u3064\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30a2\u30df\u30ce\u9178\u69cb\u9020\u306f\u975e\u5e38\u306b\u985e\u4f3c\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u306f N \u672b\u7aef\u3068 C \u672b\u7aef\u306e 2 \u3064\u306e\u7a7a\u9593\u30c9\u30e1\u30a4\u30f3\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib67\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib67\"><span class=\"anchor-text\">[67]<\/span><\/a>GSDMD\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u9577\u9396\u30a2\u30df\u30ce\u9178\u3067\u3042\u308b\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u9178\u6027\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/acid-protein\">\u9178\u6027\u30bf\u30f3\u30d1\u30af\u8cea<\/a>\u3001N \u672b\u7aef\u30c9\u30e1\u30a4\u30f3\u3068 C \u672b\u7aef\u30c9\u30e1\u30a4\u30f3\u306e\u9593\u306e\u69cb\u9020\u306f\u6bd4\u8f03\u7684\u7de9\u3084\u304b\u3067\u3059\u3002 GSDMD \u306f\u901a\u5e38\u3001\u6b21\u306e\u4f4d\u7f6e\u3067\u5207\u65ad\u3055\u308c\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30a2\u30df\u30ce\u9178\u914d\u5217\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/peptide-sequence\">\u30a2\u30df\u30ce\u9178\u914d\u5217<\/a>\u00a0275\u3001N\u672b\u7aef\u30c9\u30e1\u30a4\u30f3\u3068C\u672b\u7aef\u30c9\u30e1\u30a4\u30f3\u3092\u9732\u51fa\u3055\u305b\u308b\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u54fa\u4e73\u985e\u7d30\u80de\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mammalian-cell\">\u54fa\u4e73\u985e\u7d30\u80de<\/a>GSDMD\u306e\u5358\u7d14\u306aN\u672b\u7aef\u69cb\u9020\u306f\u7d30\u80de\u306e\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u305d\u306e\u305f\u3081\u3001GSDMD\u306fN\u672b\u7aef\u30c9\u30e1\u30a4\u30f3\u3092\u767a\u73fe\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u304c\u3001\u3059\u3079\u3066\u306eGSDMD\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u767a\u73fe\u3059\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib68\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib68\"><span class=\"anchor-text\">[68]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib69\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib69\"><span class=\"anchor-text\">[69]<\/span><\/a>\u3002\u3057\u304b\u3057\u3001\u7814\u7a76\u306b\u3088\u308a\u3001GSDMD\u306eN\u672b\u7aef\u30c9\u30e1\u30a4\u30f3\u304c\u57f9\u990a\u306e\u305f\u3081\u306b\u5927\u8178\u83cc\u306b\u5c0e\u5165\u3055\u308c\u308b\u3068\u3001\u5f37\u3044\u6bd2\u6027\u52b9\u679c\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5bfe\u7167\u7684\u306b\u3001\u7121\u50b7\u306e GSDMD \u304a\u3088\u3073 GSDMD \u306e C \u672b\u7aef\u30c9\u30e1\u30a4\u30f3\u306f\u6bd4\u8f03\u7684\u4f4e\u3044\u6bd2\u6027\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib70\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib70\"><span class=\"anchor-text\">[70]<\/span><\/a>\u7d30\u80de\u5185GSDMD\u306eN\u672b\u7aef\u69cb\u9020\u306f\u3001\u640d\u50b7\u56e0\u5b50\u306e\u4fb5\u5165\u306b\u3088\u308a\u5f90\u3005\u306b\u7d30\u80de\u819c\u306b\u79fb\u884c\u3057\u3001\u7d30\u80de\u819c\u4e0a\u3067\u30db\u30b9\u30db\u30b5\u30eb\u30b3\u30b7\u30ca\u30fc\u30bc\u3068\u7279\u7570\u7684\u306b\u7d50\u5408\u3057\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30db\u30b9\u30d5\u30a1\u30c1\u30b8\u30eb\u30bb\u30ea\u30f3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/phosphatidylserine\">\u30db\u30b9\u30d5\u30a1\u30c1\u30b8\u30eb\u30bb\u30ea\u30f3<\/a>\u00a0\u7d30\u80de\u819c\u4e0a\u3067\u751f\u7269\u5b66\u7684\u52b9\u679c\u3092\u751f\u307f\u51fa\u3059\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib71\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib71\"><span class=\"anchor-text\">[71]<\/span><\/a>\u539f\u5b50\u529b\u306a\u3069\u306e\u6a5f\u5668\u3092\u4f7f\u7528\u3057\u3066\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u96fb\u5b50\u9855\u5fae\u93e1\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/electron-microscopy\">\u96fb\u5b50\u9855\u5fae\u93e1\u6cd5<\/a>\u00a0L. Sborgi \u306f\u3001\u4f4e\u6e29\u96fb\u5b50\u9855\u5fae\u93e1\u6cd5\u306b\u3088\u308a\u3001GSMDD \u306e N \u672b\u7aef\u69cb\u9020\u304c\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u3068\u7d50\u5408\u3057\u3066\u3001\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u4e0a\u306b\u4e2d\u7a7a\u306e\u74b0\u72b6\u30dd\u30ea\u30de\u30fc\u3092\u5f62\u6210\u3067\u304d\u308b\u3053\u3068\u3092\u89b3\u5bdf\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u30dd\u30ea\u30de\u30fc\u306f\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u7d30\u5b54\u306e\u5f62\u6210\u3092\u8a98\u5c0e\u3057\u3001\u3053\u308c\u306b\u3088\u308a\u3001\u5185\u56e0\u6027\u640d\u50b7\u304c\u767a\u751f\u3057\u305f\u3068\u304d\u306b GSDMD \u304c\u7d30\u80de\u306e\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002\u5916\u90e8\u306e\u5834\u5408\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u75c5\u539f\u4f53\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathogen\">\u75c5\u539f\u4f53<\/a>\u00a0\u4fb5\u5165\u3059\u308b\u3068\u3001\u75c5\u539f\u4f53\u306e\u7d30\u80de\u8868\u9762\u306b\u5438\u7740\u3057\u3001\u7d30\u80de\u3092\u6eb6\u89e3\u3059\u308b\u3053\u3068\u3067\u5916\u90e8\u306e\u6709\u5bb3\u7269\u8cea\u304b\u3089\u4f53\u3092\u5b88\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib72\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib72\"><span class=\"anchor-text\">[72]<\/span><\/a>\u3002 GSDMD \u306f\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-1\/4\/5\/11 \u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e0b\u6d41\u306b\u7279\u7570\u7684\u306b\u7d50\u5408\u3059\u308b\u7269\u8cea\u3067\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/signal-transduction\">\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib73\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib73\"><span class=\"anchor-text\">[73]<\/span><\/a>\u30ab\u30b9\u30d1\u30fc\u30bc-1\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u306e\u8907\u5408\u4f53\u306b\u3088\u3063\u3066\u751f\u6210\u3055\u308c\u308b\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u53cd\u5fdc\u3092\u901a\u3058\u3066\u3001\u4e0b\u6d41\u306eIL-1\u03b2\u3068IL-18\u306e\u7d30\u80de\u819c\u304b\u3089\u306e\u653e\u51fa\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u6d3b\u6027\u5316\u3055\u308c\u305f\u30ab\u30b9\u30d1\u30fc\u30bc-1\u306fGSDMD\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5207\u65ad\u3057\u3001GSDMD\u3092\u6d3b\u6027\u30da\u30d7\u30c1\u30c9\u306b\u5909\u63db\u3057\u307e\u3059\u3002GSDMD\u306e\u5206\u89e3\u7523\u7269\u306f\u7d30\u80de\u819c\u306b\u7279\u7570\u7684\u306b\u7d50\u5408\u3057\u3001\u7d30\u80de\u5916\u6c34\u5206\u5b50\u306a\u3069\u306e\u6210\u5206\u304c\u7d30\u5b54\u304b\u3089\u7d30\u80de\u819c\u306b\u5165\u308a\u8fbc\u307f\u3001\u7d30\u80de\u3092\u81a8\u5f35\u3055\u305b\u3001\u6700\u7d42\u7684\u306b\u7834\u88c2\u3055\u305b\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib74\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib74\"><span class=\"anchor-text\">[74]<\/span><\/a>.<\/p>\n<\/section>\n<\/section>\n<section id=\"sec0040\">\n<h3 id=\"sect0060\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.3.\u975e\u30b3\u30fc\u30c9RNA\u306fIS\u306b\u304a\u3051\u308b\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u306b\u95a2\u4e0e\u3059\u308b<\/h3>\n<p id=\"p0060\">\u8fd1\u5e74\u3001\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306e\u767a\u751f\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u306e\u5236\u5fa1\u30e1\u30ab\u30cb\u30ba\u30e0\u3082\u5b8c\u5168\u306b\u958b\u767a\u3055\u308c\u307e\u3057\u305f\u3002\u73fe\u4ee3\u306e\u5206\u5b50\u751f\u7269\u5b66\u7814\u7a76\u3067\u306f\u3001\u30b2\u30ce\u30e0\u306e98%\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u306a\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u9577\u9396\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\uff08lncRNA\uff09\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0\u6a5f\u80fd\u3092\u6301\u305f\u306a\u3044RNA\u3067\u3042\u308a\u3001\u9577\u3055\u304c200\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u3092\u8d85\u3048\u308b\u305f\u3081\u305d\u306e\u3088\u3046\u306b\u540d\u4ed8\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib75\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib75\"><span class=\"anchor-text\">[75]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib76\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib76\"><span class=\"anchor-text\">[76]<\/span><\/a>\u3057\u304b\u3057\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089 lncRNA \u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/long-untranslated-rna\">lncRNA<\/a>\u00a0\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3059\u308b\u6a5f\u80fd\u306f\u306a\u3044\u304c\u3001\u4f53\u5185\u3067\u6700\u3082\u767a\u73fe\u3057\u3066\u3044\u308b\u907a\u4f1d\u5b50\u3067\u3042\u308a\u3001\u8ee2\u5199\u306b\u304a\u3044\u3066\u6700\u3082\u4fdd\u5b58\u3055\u308c\u3066\u3044\u308b\u907a\u4f1d\u5b50\u3067\u3042\u308b\u3002\u4f53\u5185\u306e\u91cd\u8981\u306a\u75c5\u7406\u5b66\u7684\u304a\u3088\u3073\u751f\u7406\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u3001\u7279\u306b\u518d\u704c\u6d41\u969c\u5bb3\u95a2\u9023\u75be\u60a3\u306b\u95a2\u4e0e\u3057\u3001\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib77\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib77\"><span class=\"anchor-text\">[77]<\/span><\/a>\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u7d30\u80de\u306b\u304a\u3051\u308blncRNA-H19\u306e\u767a\u73fe\u30ec\u30d9\u30eb\u306f\u518d\u704c\u6d41\u306e\u6301\u7d9a\u6642\u9593\u3068\u6b63\u306e\u76f8\u95a2\u95a2\u4fc2\u306b\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib78\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib78\"><span class=\"anchor-text\">[78]<\/span><\/a>LncRNA-H19\u306e\u904e\u5270\u767a\u73fe\u306f\u3001\u4e0b\u6d41\u30b7\u30b0\u30ca\u30eb\u5206\u5b50NLRP3\/6\u306e\u767a\u73fe\u3092\u4fc3\u9032\u3057GSDMD\u3092\u958b\u59cb\u3059\u308b\u969b\u306b\u708e\u75c7\u6027\u5f79\u5272\u3092\u679c\u305f\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib79\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib79\"><span class=\"anchor-text\">[79]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib80\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib80\"><span class=\"anchor-text\">[80]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib81\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib81\"><span class=\"anchor-text\">[81]<\/span><\/a>\u3002 lncRNA-H19 \u306f\u30ab\u30b9\u30d1\u30fc\u30bc\u30bf\u30f3\u30d1\u30af\u8cea\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u30e1\u30f3\u30d0\u30fc\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib82\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib82\"><span class=\"anchor-text\">[82]<\/span><\/a>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u4e0d\u5168\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u6d3b\u6027\u5316\u306b\u95a2\u4e0e\u3057\u3001\u795e\u7d4c\u7d30\u80de\u306e\u640d\u50b7\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib83\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib83\"><span class=\"anchor-text\">[83]<\/span><\/a>\u3002\u5206\u5b50\u69cb\u9020\u306e\u5236\u5fa1\u306b\u52a0\u3048\u3066\u3001lncRNA-H19 \u306f\u3055\u3089\u306b\u591a\u304f\u306e\u8ee2\u5199\u56e0\u5b50\u3092\u52d5\u54e1\u3057\u3066 mRNA \u8ee2\u5199\u30d7\u30ed\u30bb\u30b9\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u3082\u3067\u304d\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib84\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib84\"><span class=\"anchor-text\">[84]<\/span><\/a>\u3002\u3055\u3089\u306b\u3001lncRNA-H19 \u306f\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u6838\u8f38\u9001\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nucleocytoplasmic-transport\">\u6838\u8f38\u9001<\/a>\u00a0\u8ee2\u5199\u56e0\u5b50\u306e\u30d7\u30ed\u30bb\u30b9\u3092\u5236\u5fa1\u3057\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u3088\u308a\u591a\u304f\u306e\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u7279\u7570\u7684\u767a\u73fe\u3092\u5897\u52a0\u3055\u305b\u3001\u708e\u75c7\u30ab\u30b9\u30b1\u30fc\u30c9\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3092\u751f\u6210\u3057\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u865a\u8840\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemia\">\u865a\u8840<\/a>\u00a0\u767a\u751f\u3059\u308b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib84\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib84\"><span class=\"anchor-text\">[84]<\/span><\/a>\u3002\u3057\u305f\u304c\u3063\u3066\u3001lncRNA-H19 \u306f\u3001\u6b21\u306e\u3088\u3046\u306a\u5834\u5408\u306b\u5f37\u3044\u5371\u967a\u4fe1\u53f7\u3068\u306a\u308a\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089 CIRI \u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunoreactive-insulin\">\u30b7\u30ea<\/a>\u00a0H19 \u306e\u963b\u5bb3\u304c\u8d77\u3053\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u6cbb\u7642\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/therapeutic-procedure\">\u51e6\u7406<\/a>\u00a0\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u306e\u5834\u5408\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib84\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib84\"><span class=\"anchor-text\">[84]<\/span><\/a>\u3002\u865a\u8840\u518d\u704c\u6d41\u50b7\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u306e\u3042\u308b AIM2 \u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u5a92\u4ecb\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3067\u306f\u3001lincRNA MEG3\/miR-485\/AIM2 \u8ef8\u304c CIRI \u4e2d\u306b\u30ab\u30b9\u30d1\u30fc\u30bc 1 \u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u4fc3\u9032\u3059\u308b\u305f\u3081\u3001\u3053\u306e\u8ef8\u306f\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u306e\u52b9\u679c\u7684\u306a\u6cbb\u7642\u6a19\u7684\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089IS\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/brain-ischemia\">\u306f<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib84\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib84\"><span class=\"anchor-text\">[84]<\/span><\/a>\u3002 \u306e\u305f\u3081\u306b\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u514d\u75ab\u5236\u5fa1\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunoregulation\">\u514d\u75ab\u8abf\u7bc0<\/a>\u00a0\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306eLncRNA-Fendrr\u304c\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ubiquitination\">\u30e6\u30d3\u30ad\u30c1\u30f3\u5316<\/a>\u00a0HERC2 \u3092\u4ecb\u3057\u305f NLRC4 \u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5206\u89e3\u3068\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u5236\u5fa1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib85\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib85\"><span class=\"anchor-text\">[85]<\/span><\/a>\u3002\u5f35\u3089\u3002 lncRNA NEAT1\/miR-22\u20133p \u8ef8\u304c\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u6291\u5236\u3057\u3001CIRI \u640d\u50b7\u3092\u8efd\u6e1b\u3059\u308b\u3053\u3068\u3092\u767a\u898b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib86\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib86\"><span class=\"anchor-text\">[86]<\/span><\/a>\u3002 IS\u5f8c\u306ein vitro\u9178\u7d20\u30b0\u30eb\u30b3\u30fc\u30b9\u6b20\u4e4f\uff08OGD\uff09\u640d\u50b7\u5b9f\u9a13\u3067\u306f\u3001OGD\u304cNOD\u69d8\u53d7\u5bb9\u4f53\u30bf\u30f3\u30d1\u30af\u8cea3\uff08NLRP3\uff09\u306e\u767a\u73fe\u3092\u5897\u52a0\u3055\u305b\u3001NSC\u306e\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u6b7b\u3092\u8a98\u5c0e\u3057\u3001NSC\u306f\u56de\u5fa9\u3057\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u9ad8\u5727\u9178\u7d20\u7642\u6cd5\u306e\u8a73\u7d30\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hyperbaric-medicine\">\u9ad8\u5727\u9178\u7d20\u7642\u6cd5<\/a>\u3002\u4e0a\u65b9\u5236\u5fa1\u3055\u308c\u305f lncRNA-H19 \u306f miR-423-5p \u306e\u5206\u5b50\u30b9\u30dd\u30f3\u30b8\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3001OGD \u5f8c\u306b NLRP3 \u3092\u6a19\u7684\u306b\u3057\u3066\u795e\u7d4c\u5e79\u7d30\u80de (NSC) \u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u9ad8\u5727\u9178\u7d20\u7642\u6cd5\u306f\u3001lncRNA-H19\/miR-423\u20135p\/NLRP3 \u8ef8\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001NSC \u3092\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u304b\u3089\u4fdd\u8b77\u3059\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib87\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib87\"><span class=\"anchor-text\">[87]<\/span><\/a>miR-21\u306f\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089 microRNA \u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microrna\">\u30de\u30a4\u30af\u30edRNA<\/a>\u00a0(miRNA) \u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u767a\u751f\u3068\u5bc6\u63a5\u306b\u95a2\u4fc2\u3057\u3066\u3044\u307e\u3059\u3002\u7814\u7a76\u306b\u3088\u308a\u3001miR-21 \u306f\u3001\u708e\u75c7\u6027\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u7d4c\u8def\u3092\u4ecb\u3057\u305f NF-\u03baB \u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u4ecb\u3057\u3066\u3001NLRP3 \u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7279\u7570\u7684\u306b\u5236\u5fa1\u3057\u3001NLRP3 \u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6d3b\u6027\u5316\u3057\u3001NLRP3 \u5206\u6ccc\u3092\u523a\u6fc0\u3057\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u5185\u3067\u767a\u73fe\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib88\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib88\"><span class=\"anchor-text\">[88]<\/span><\/a>miR-21\u306fNLRP3\u3092\u6d3b\u6027\u5316\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u4e0b\u6d41\u306e\u30ab\u30b9\u30d1\u30fc\u30bc1\u306e\u6d3b\u6027\u5316\u3092\u8abf\u7bc0\u3057\u3001IL-1\u03b2\u306e\u5206\u6ccc\u3092\u4fc3\u9032\u3057\u3001\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306e\u767a\u751f\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3082\u3067\u304d\u308b\u3002miR-21\u304c\u6b20\u640d\u3059\u308b\u3068\u3001NLRP3\u306b\u3088\u3063\u3066\u8abf\u7bc0\u3055\u308c\u308b\u30ab\u30b9\u30d1\u30fc\u30bc1\u7d4c\u8def\u306e\u767a\u73fe\u304c\u5927\u5e45\u306b\u6e1b\u5c11\u3059\u308b\u3002\u3057\u305f\u304c\u3063\u3066\u3001miR-21\u306e\u767a\u73fe\u30ec\u30d9\u30eb\u3082\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306e\u767a\u751f\u3092\u8abf\u7bc0\u3059\u308b\u4e0a\u3067\u91cd\u8981\u306a\u30ea\u30f3\u30af\u3067\u3042\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib89\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib89\"><span class=\"anchor-text\">[89]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib90\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib90\"><span class=\"anchor-text\">[90]<\/span><\/a>\u3002\u6700\u65b0\u306e\u5206\u5b50\u751f\u7269\u5b66\u306e\u7814\u7a76\u3067\u306f\u3001miR-214\u20133p \u306b\u306f\u30ab\u30b9\u30d1\u30fc\u30bc 1 \u306e\u7d50\u5408\u90e8\u4f4d\u304c\u3042\u308a\u3001\u30ab\u30b9\u30d1\u30fc\u30bc 1 \u306e\u767a\u751f\u306b\u7279\u7570\u7684\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u708e\u75c7\u53cd\u5fdc\u3092\u5236\u5fa1\u3057\u3001\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u767a\u751f\u7387\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib91\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib91\"><span class=\"anchor-text\">[91]<\/span><\/a>.<\/p>\n<div>\n<p id=\"p0065\">\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u6b21\u306e\u3088\u3046\u306b\u307e\u3068\u3081\u3089\u308c\u3066\u3044\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#fig0005\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"fig0005\"><span class=\"anchor-text\">\u56f31<\/span><\/a>.<\/p>\n<figure id=\"fig0005\" class=\"figure text-xs\"><img decoding=\"async\" src=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr1.jpg\" alt=\"Fig. 1\" height=\"414\" aria-describedby=\"cap0005\" \/><\/p>\n<ol class=\"u-margin-s-bottom\">\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"\u9ad8\u89e3\u50cf\u5ea6\u753b\u50cf\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9 (294KB)\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr1_lrg.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9:\u00a0<span class=\"download-link-title\">\u9ad8\u89e3\u50cf\u5ea6\u753b\u50cf\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9 (294KB)<\/span><\/span><\/a><\/li>\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"\u30d5\u30eb\u30b5\u30a4\u30ba\u306e\u753b\u50cf\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr1.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9:\u00a0<span class=\"download-link-title\">\u30d5\u30eb\u30b5\u30a4\u30ba\u306e\u753b\u50cf\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9<\/span><\/span><\/a><\/li>\n<\/ol>\n<p id=\"sp0005\"><span class=\"label\">\u56f31<\/span>\u3002\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u5206\u5b50\u6a5f\u69cb (\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u6a5f\u69cb\u306b\u306f\u3001\u6a19\u6e96\u7684\u306a\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u7d4c\u8def\u3068\u975e\u6a19\u6e96\u7684\u306a\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u7d4c\u8def\u304c\u542b\u307e\u308c\u307e\u3059\u3002\u6a19\u6e96\u7684\u306a\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u7d4c\u8def\u306f\u3001DAMP \u307e\u305f\u306f PAMP \u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002\u975e\u6a19\u6e96\u7684\u306a\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u7d4c\u8def\u306f\u3001\u7d30\u80de\u5916\u30b0\u30e9\u30e0\u9670\u6027\u83cc\u306e LPS \u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059)\u30c8\u30ea\u30ac\u30fc\u5f8c\u3001\u4e00\u9023\u306e\u5206\u5b50\u9593\u76f8\u4e92\u4f5c\u7528\u3092\u901a\u3058\u3066\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u304c\u30c8\u30ea\u30ac\u30fc\u3055\u308c\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089 TLR \u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/toll-like-receptor\">TLR<\/a>: Toll\u69d8\u53d7\u5bb9\u4f53; GSDM: Gsdermin; NLRP3: \u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u7d50\u5408\u30aa\u30ea\u30b4\u30de\u30fc\u5316\u30c9\u30e1\u30a4\u30f3\u69d8\u53d7\u5bb9\u4f53\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089 pyrin \u30c9\u30e1\u30a4\u30f3\u306e\u8a73\u7d30\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyrin-domain\">\u30d4\u30ea\u30f3\u30c9\u30e1\u30a4\u30f3<\/a>\u00a03 \u3092\u542b\u3080; DAMP: \u640d\u50b7\u95a2\u9023\u5206\u5b50\u30d1\u30bf\u30fc\u30f3; PAMP: \u75c5\u539f\u4f53\u95a2\u9023\u5206\u5b50\u30d1\u30bf\u30fc\u30f3)\u3002<\/p>\n<\/figure>\n<\/div>\n<\/section>\n<section id=\"sec0045\">\n<h3 id=\"sect0065\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.4. \u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3068\u4ed6\u306e\u7d30\u80de\u969c\u5bb3\u3068\u306e\u95a2\u4fc2<\/h3>\n<p id=\"p0070\">\u8133\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u306e\u767a\u751f\u306b\u306f\u591a\u304f\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u65e2\u77e5\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001\u708e\u75c7\u53cd\u5fdc\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u969c\u5bb3\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u969c\u5bb3\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306a\u3069\u306e\u3055\u307e\u3056\u307e\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306f\u8133\u865a\u8840\u518d\u704c\u6d41\u640d\u50b7\u306e\u3042\u3089\u3086\u308b\u5074\u9762\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u4ed6\u306e\u640d\u50b7\u3068\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p id=\"p0075\">\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3068\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u767a\u751f\u306f\u3069\u3061\u3089\u3082\u7d30\u80de\u6b7b\u306e\u4e00\u7a2e\u3067\u3059\u304c\u3001\u6839\u672c\u7684\u306b\u7570\u306a\u308a\u307e\u3059\u3002\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306f\u751f\u7406\u7684\u306a\u7d30\u80de\u6b7b\u3067\u3059\u304c\u3001\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306f\u8eab\u4f53\u306e\u640d\u50b7\u5f8c\u306e\u75c5\u7406\u7684\u306a\u7d30\u80de\u6b7b\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib92\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib92\"><span class=\"anchor-text\">[92]<\/span><\/a>\u3002\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3068\u306f\u3001\u4e16\u754c\u306b\u5e83\u304f\u5b58\u5728\u3059\u308b\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u73fe\u8c61\u306e\u4e00\u7a2e\u3067\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u771f\u6838\u7d30\u80de\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/eukaryotic-cell\">\u771f\u6838\u7d30\u80de<\/a>\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306f\u3001\u4e00\u822c\u7684\u306b\u30b7\u30e3\u30da\u30ed\u30f3\u4ecb\u5728\u578b\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3001\u30df\u30af\u30ed\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3001\u30de\u30af\u30ed\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e3\u7a2e\u985e\u306b\u5206\u3051\u3089\u308c\u3001\u73fe\u5728\u3001\u30de\u30af\u30ed\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306b\u95a2\u3059\u308b\u7814\u7a76\u306f\u6570\u591a\u304f\u884c\u308f\u308c\u3066\u3044\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib93\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib93\"><span class=\"anchor-text\">[93]<\/span><\/a>\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306f\u7d30\u80de\u306e\u6b63\u5e38\u306a\u4ee3\u8b1d\u904e\u7a0b\u306b\u6b20\u304b\u305b\u306a\u3044\u90e8\u5206\u3067\u3059\u3002\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u304c\u963b\u5bb3\u3055\u308c\u308b\u3068\u3001\u7d44\u7e54\u3001\u81d3\u5668\u3001\u7d30\u80de\u306b\u6709\u5bb3\u7269\u8cea\u304c\u84c4\u7a4d\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u304c\u904e\u5270\u306b\u6d3b\u6027\u5316\u3055\u308c\u308b\u3068\u3001\u91cd\u8981\u306a\u7d30\u80de\u5185\u5c0f\u5668\u5b98\u3084\u5fc5\u9808\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u7834\u58ca\u3055\u308c\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306b\u3088\u308b\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib94\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib94\"><span class=\"anchor-text\">[94]<\/span><\/a>.<\/p>\n<p id=\"p0080\">\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3068\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306f\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002\u901a\u5e38\u306e\u72b6\u6cc1\u4e0b\u3067\u306f\u3001\u751f\u4f53\u5185\u3067\u306e\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3068\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u767a\u751f\u306f\u52d5\u7684\u5e73\u8861\u72b6\u614b\u306b\u3042\u308a\u307e\u3059\u3002\u4f53\u304c\u5916\u90e8\u523a\u6fc0\u306b\u5bfe\u3057\u3066\u708e\u75c7\u53cd\u5fdc\u3092\u8d77\u3053\u3059\u3068\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3068\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib95\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib95\"><span class=\"anchor-text\">[95]<\/span><\/a>\u4f8b\u3048\u3070\u3001NF-\u03baB\u306f\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/signal-transduction-pathway\">\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def<\/a>\u00a0\u591a\u304f\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u95a2\u4e0e\u3057\u307e\u3059\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-signaling-pathway\">\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def<\/a>\u00a0\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u9054\u6210\u3059\u308b\u305f\u3081\u306b\u3001\u3053\u306e\u7814\u7a76\u306fNF-\u03baB\u907a\u4f1d\u5b50\u3092\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u3057\u305fIS\u30de\u30a6\u30b9\u306b\u304a\u3044\u3066\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089 mTOR \u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mammalian-target-of-rapamycin\">mTOR<\/a>\u00a0\u6d3b\u6027\u304c\u963b\u5bb3\u3055\u308c\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u30ec\u30d9\u30eb\u304c\u5f37\u5316\u3055\u308c\u307e\u3057\u305f\u3002 NF-\u03baB \u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u6d3b\u6027\u5316\u7d4c\u8def\u306f\u3001NF-\u03baB \u8a98\u5c0e\u30ad\u30ca\u30fc\u30bc\u3092\u6d3b\u6027\u5316\u3059\u308b\u591a\u6570\u306e\u523a\u6fc0\u3067\u3042\u308a\u3001I\u03baK\u03b1\u3001I\u03baKB\u3001\u304a\u3088\u3073 I\u03baK\u03b3 \u4e09\u91cf\u4f53\u3092\u6d3b\u6027\u5316\u3057\u3001\u305d\u306e\u7d50\u679c I\u03baB \u306e\u30ea\u30f3\u9178\u5316\u3068\u5206\u89e3\u304c\u8d77\u3053\u308a\u3001\u6700\u7d42\u7684\u306b NF-\u03baB \u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u304c\u6d3b\u6027\u5316\u3055\u308c\u307e\u3059\u3002 \u3002\u6d3b\u6027\u5316\u5f8c\u3001NF-\u03baB \u306f\u7d30\u80de\u306b\u5165\u308a\u3001\u5bfe\u5fdc\u3059\u308b DNA \u53d7\u5bb9\u4f53\u306b\u7279\u7570\u7684\u306b\u7d50\u5408\u3057\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u708e\u75c7\u56e0\u5b50\u306e\u8ee2\u5199\u3092\u523a\u6fc0\u3057\u3001\u708e\u75c7\u56e0\u5b50 TNF-\u03b1\u3001IL-1\u03b2\u3001IL-6 \u306e\u5927\u91cf\u767a\u73fe\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u7814\u7a76\u306b\u3088\u308a\u3001NF-\u03baB \u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u304c\u3001\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u5c0e\u3059\u308b\u305f\u3081\u306e\u91cd\u8981\u306a\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u30bf\u30f3\u30d1\u30af\u8cea NLRP3 \u306e\u8ee2\u5199\u524d\u304a\u3088\u3073\u8ee2\u5199\u5f8c\u30ec\u30d9\u30eb\u306e\u6d3b\u6027\u5316\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8c4a\u5bcc\u306b\u767a\u73fe\u3059\u308b\u708e\u75c7\u56e0\u5b50\u306f\u3001\u4f53\u5185\u3067\u708e\u75c7\u30ab\u30b9\u30b1\u30fc\u30c9\u3092\u8a98\u767a\u3057\u3001\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u767a\u3057\u3001\u3055\u3089\u306b\u708e\u75c7\u53cd\u5fdc\u3092\u62e1\u5927\u3055\u305b\u3066\u3001\u8133\u640d\u50b7\u3092\u60aa\u5316\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib96\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib96\"><span class=\"anchor-text\">[96]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib97\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib97\"><span class=\"anchor-text\">[97]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib98\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib98\"><span class=\"anchor-text\">[98]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0050\">\n<h3 id=\"sect0070\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.5. IS\u306b\u95a2\u4e0e\u3059\u308b\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3068\u708e\u75c7\u306e\u30e1\u30ab\u30cb\u30ba\u30e0<\/h3>\n<p id=\"p0085\">\u708e\u75c7\u30ab\u30b9\u30b1\u30fc\u30c9\u306fIS\u306e\u3055\u307e\u3056\u307e\u306a\u6bb5\u968e\u306b\u5b58\u5728\u3059\u308b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib99\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib99\"><span class=\"anchor-text\">[99]<\/span><\/a>IS\u306e\u521d\u671f\u6bb5\u968e\u3067\u306f\u3001\u8133\u5185\u306e\u8840\u6d41\u304c\u9045\u304f\u306a\u308a\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u597d\u4e2d\u7403\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neutrophil\">\u597d\u4e2d\u7403<\/a>\u00a0\u306b\u5f93\u3046\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u5185\u76ae\u7d30\u80de\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/endothelial-cell\">\u5185\u76ae\u7d30\u80de<\/a>\u00a0\u865a\u8840\u6027\u8840\u7ba1\u306e\u708e\u75c7\u304c\u8d77\u3053\u308a\u3001\u521d\u671f\u306e\u6025\u6027\u708e\u75c7\u53cd\u5fdc\u304c\u59cb\u307e\u308a\u307e\u3059\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib100\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib100\"><span class=\"anchor-text\">[100]<\/span><\/a>\u3002\u8133\u865a\u8840\u5f8c\u306b\u518d\u6f45\u6d41\u304c\u8d77\u3053\u308b\u3068\u3001\u5916\u56e0\u6027\u708e\u75c7\u56e0\u5b50\u3001\u708e\u75c7\u7d30\u80de\u3001\u708e\u75c7\u56e0\u5b50\u304c\u8840\u6db2\u8133\u95a2\u9580\u3092\u901a\u904e\u3057\u3001\u518d\u6f45\u6d41\u5f8c\u306e\u865a\u8840\u306b\u3088\u308b\u526f\u6b21\u7684\u306a\u5f71\u97ff\u304c\u751f\u3058\u3001\u591a\u6570\u306e\u9178\u5316\u56e0\u5b50\u3084\u708e\u75c7\u56e0\u5b50\u304c\u653e\u51fa\u3055\u308c\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/radical-chemistry\">\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb<\/a>\u3053\u306e\u3068\u304d\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u8133\u7d44\u7e54\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-tissue\">\u8133\u7d44\u7e54<\/a>\u00a0\u5f90\u3005\u306b\u5927\u91cf\u306b\u6d3b\u6027\u5316\u3055\u308c\u3001\u3088\u308a\u591a\u304f\u306e\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u708e\u75c7\u6027\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammatory-mediator\">\u708e\u75c7\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc<\/a>\u3002\u3053\u306e\u30bf\u30a4\u30d7\u306e\u708e\u75c7\u6027\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u306f\u3001\u8133\u7d44\u7e54\u306e\u5185\u76ae\u7d30\u80de\u3092\u904e\u5270\u306b\u6d3b\u6027\u5316\u3057\u3001\u5927\u91cf\u306e\u708e\u75c7\u6027\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u3092\u751f\u6210\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u7d44\u7e54\u56e0\u5b50\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/thromboplastin\">\u7d44\u7e54\u56e0\u5b50<\/a>\u00a0\u30a2\u30df\u30ce\u9178\u306e\u6bd2\u6027\u3092\u84c4\u7a4d\u3057\u3001\u9178\u5316\u56e0\u5b50\u3001\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u306e\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u4e00\u9178\u5316\u70ad\u7d20\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/carbon-monoxide\">\u4e00\u9178\u5316\u70ad\u7d20<\/a>NF-\u03baB\u3001Toll\u69d8\u53d7\u5bb9\u4f53\u3001Nod\u69d8\u53d7\u5bb9\u4f53\uff08NLR\uff09\u306a\u3069\u306e\u708e\u75c7\u53cd\u5fdc\u95a2\u9023\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3057\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib101\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib101\"><span class=\"anchor-text\">[101]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib102\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib102\"><span class=\"anchor-text\">[102]<\/span><\/a>\u4f8b\u3048\u3070\u3001NLR\u306f\u3001\u7814\u7a76\u306b\u3088\u308a23\u306eNLR\u30d5\u30a1\u30df\u30ea\u30fc\u30e1\u30f3\u30d0\u30fc\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306f\u4e3b\u306b\u7d30\u80de\u8cea\u3067\u767a\u73fe\u3057\u3001\u4f53\u306e\u81ea\u7136\u514d\u75ab\u5fdc\u7b54\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002NLR\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u30e1\u30f3\u30d0\u30fc\u3067\u3042\u308bNalp1\u3001Nalp3\u3001Nalp5\u3001\u304a\u3088\u3073Ipaf\u306f\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30a2\u30c0\u30d7\u30bf\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/adaptor-protein\">\u30a2\u30c0\u30d7\u30bf\u30fc\u30bf\u30f3\u30d1\u30af\u8cea<\/a>\u00a0ASC\u306f\u708e\u75c7\u53cd\u5fdc\u306e\u9023\u9396\u3092\u958b\u59cb\u3057\u3001\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u5a92\u4ecb\u3059\u308b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib103\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib103\"><span class=\"anchor-text\">[103]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib104\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib104\"><span class=\"anchor-text\">[104]<\/span><\/a>NLRP3\u306f\u708e\u75c7\u56e0\u5b50\u306e\u91cd\u8981\u306a\u69cb\u6210\u8981\u7d20\u3067\u3042\u308b\u3002NLRP3\u306b\u306fPYD\u3001NACHT\u3001LRR\u306e3\u3064\u306e\u30c9\u30e1\u30a4\u30f3\u304c\u542b\u307e\u308c\u3066\u304a\u308a\u3001LRR-NACHT-PYD\uff1aPYD-CARD\uff1aCARD-CARDC\u306e\u30b9\u30da\u30fc\u30bc\u30c9\u30e1\u30a4\u30f3\u3067\u8868\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u3053\u308c\u306f\u5185\u56e0\u6027\u640d\u50b7\u306e\u3055\u307e\u3056\u307e\u306a\u30b7\u30b0\u30ca\u30eb\u306b\u53cd\u5fdc\u3059\u308b\u305f\u3081\u3001NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u6d3b\u6027\u5316\u304c\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306e\u4e3b\u306a\u30bf\u30a4\u30d7\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib105\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib105\"><span class=\"anchor-text\">[105]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib106\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib106\"><span class=\"anchor-text\">[106]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib107\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib107\"><span class=\"anchor-text\">[107]<\/span><\/a>.<\/p>\n<p id=\"p0090\">\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306f\u3001\u4f53\u304c\u611f\u67d3\u3084\u7d30\u80de\u640d\u50b7\u306e\u4fe1\u53f7\u3092\u53d7\u3051\u53d6\u3063\u305f\u5f8c\u306b\u7d44\u307f\u7acb\u3066\u3089\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u3067\u3042\u308a\u3001\u30d7\u30ed\u30ab\u30b9\u30d1\u30fc\u30bc1\u306e\u30ea\u30af\u30eb\u30fc\u30c8\u3068\u6d3b\u6027\u5316\u306e\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u3002\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u30bf\u30f3\u30d1\u30af\u8ceaNLRP3\u306f\u3001\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u30a2\u30c0\u30d7\u30bf\u30fc\u5206\u5b50ASC\u3092\u4f7f\u7528\u3057\u305f\u30aa\u30ea\u30b4\u30de\u30fc\u5316\u3092\u901a\u3058\u3066\u3001\u5927\u91cf\u306e\u30d7\u30ed\u30ab\u30b9\u30d1\u30fc\u30bc1\u3092\u30ea\u30af\u30eb\u30fc\u30c8\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib108\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib108\"><span class=\"anchor-text\">[108]<\/span><\/a>\u3002\u30d7\u30ed\u30ab\u30b9\u30d1\u30fc\u30bc-1 \u306f\u30ab\u30b9\u30d1\u30fc\u30bc-1 \u306e\u524d\u99c6\u4f53\u3067\u3042\u308a\u3001\u6d3b\u6027\u578b\u30ab\u30b9\u30d1\u30fc\u30bc-1 \u306f\u7d30\u80de\u3092\u6025\u901f\u306b\u6eb6\u89e3\u3057\u3066\u7d30\u80de\u5916 IL-1\u03b2 \u304a\u3088\u3073 IL-18 \u3092\u6d3b\u6027\u5316\u3057\u3066\u653e\u51fa\u3059\u308b\u5f79\u5272\u3092\u62c5\u3063\u3066\u304a\u308a\u3001\u3053\u308c\u306b\u3088\u308a\u708e\u75c7\u53cd\u5fdc\u304c\u3055\u3089\u306b\u60aa\u5316\u3057\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u767a\u751f\u306f\u3001\u708e\u75c7\u53cd\u5fdc\u306e\u51fa\u73fe\u304a\u3088\u3073\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u5f62\u6210\u3068\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002\u8133\u865a\u8840\u518d\u704c\u6d41\u640d\u50b7\u306e\u767a\u751f\u306f\u3001\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3068\u708e\u75c7\u53cd\u5fdc\u306e\u9593\u306e\u76f8\u4e92\u4f5c\u7528\u3068\u3088\u308a\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib109\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib109\"><span class=\"anchor-text\">[109]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib110\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib110\"><span class=\"anchor-text\">[110]<\/span><\/a>\u7279\u306b\u4e2d\u67a2\u795e\u7d4c\u7cfb\u3067\u306f\u3001\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306f\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u6d3b\u6027\u5316\u3068\u5897\u6b96\u3092\u8a98\u5c0e\u3057\u3001\u591a\u6570\u306e\u708e\u75c7\u6027\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u3092\u7523\u751f\u3059\u308b\u3002\u3053\u308c\u3089\u306e\u708e\u75c7\u6027\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u306f\u5185\u76ae\u7d30\u80de\u3092\u6d3b\u6027\u5316\u3057\u3066\u69d8\u3005\u306a\u7d44\u7e54\u56e0\u5b50\u3092\u7523\u751f\u3057\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u8208\u596e\u6027\u30a2\u30df\u30ce\u9178\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/excitatory-amino-acid\">\u8208\u596e\u6027\u30a2\u30df\u30ce\u9178<\/a>\u3001\u304a\u3088\u3073\u306e\u30ea\u30ea\u30fc\u30b9\u3092\u4fc3\u9032\u3059\u308b\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u4e00\u9178\u5316\u7a92\u7d20\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nitric-oxide\">\u4e00\u9178\u5316\u7a92\u7d20<\/a>\u00a0\u305d\u3057\u3066\u9178\u7d20\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u3002\u4e0a\u8a18\u306e\u7269\u8cea\u306f\u3055\u3089\u306b\u3001NF-\u03baB \u3084 JNK2\/STAT3 \u306a\u3069\u306e\u8907\u6570\u306e\u708e\u75c7\u6027\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u3092\u3082\u305f\u3089\u3057\u3001NLRP1 \u3084 NLRP3 \u306a\u3069\u306e\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u69cb\u7bc9\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u6d3b\u6027\u5316\u3055\u308c\u305f\u30ab\u30b9\u30d1\u30fc\u30bc-1\u306f\u7d30\u80de\u306e\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u767a\u3057\u3001\u708e\u75c7\u53cd\u5fdc\u3092\u62e1\u5927\u3057\u3001\u8133\u865a\u8840\u518d\u704c\u6d41\u50b7\u5bb3\u3092\u60aa\u5316\u3055\u305b\u307e\u3059\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib111\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib111\"><span class=\"anchor-text\">[111]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib112\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib112\"><span class=\"anchor-text\">[112]<\/span><\/a>\u3002\u3044\u304f\u3064\u304b\u306e\u7814\u7a76\u3067\u306f\u3001\u91ce\u751f\u578b\u30de\u30a6\u30b9\u3068\u6bd4\u8f03\u3057\u3066\u3001AIM2\u306e\u8133\u5185\u306eAIM2\u304a\u3088\u3073IL-1\u03b2\u306e\u30ec\u30d9\u30eb\u304c\u4f4e\u3044\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3057\u305f\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30ce\u30c3\u30af\u30a2\u30a6\u30c8 \u30de\u30a6\u30b9\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/knockout-mouse\">\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9<\/a>\u00a0\u8133\u865a\u8840\u518d\u704c\u6d41\u5f8c\u306e\u5fc3\u7b4b\u6897\u585e\u5bb9\u7a4d\u306f\u6709\u610f\u306b\u6e1b\u5c11\u3057\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u795e\u7d4c\u6a5f\u80fd\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nervous-system-physiology\">\u795e\u7d4c\u6a5f\u80fd<\/a>\u00a0\u30b9\u30b3\u30a2\u3082\u5927\u5e45\u306b\u6539\u5584\u3057\u305f\u3002AIM2\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u6d3b\u6027\u5316\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u3001\u3042\u308b\u7a0b\u5ea6\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306e\u767a\u751f\u3092\u6291\u5236\u3057\u3001\u865a\u8840\u6027\u8133\u969c\u5bb3\u3092\u8efd\u6e1b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib113\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib113\"><span class=\"anchor-text\">[113]<\/span><\/a>\u305d\u306e\u305f\u3081\u3001\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u306f\u8133\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306f\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u306e\u91cd\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001\u305d\u306e\u767a\u73fe\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u3001\u4e0b\u6d41\u306e\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u3092\u540c\u6642\u306b\u963b\u5bb3\u3057\u3001\u708e\u75c7\u53cd\u5fdc\u3092\u5236\u9650\u3057\u3001\u8133\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u3092\u8efd\u6e1b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n<\/section>\n<section id=\"sec0055\">\n<h3 id=\"sect0075\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.6.\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u640d\u50b7\u306fIS\u5f8c\u306e\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u640d\u50b7\u3092\u5a92\u4ecb\u3059\u308b<\/h3>\n<p id=\"p0095\">\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u4e3b\u306b\u7d30\u80de\u306e\u597d\u6c17\u547c\u5438\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u597d\u6c17\u547c\u5438\u304c\u884c\u308f\u308c\u308b\u5834\u6240\u3067\u3059\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u3001\u7d30\u80de\u9593\u306e\u6b63\u5e38\u306a\u4fe1\u53f7\u4f1d\u9054\u3068\u795e\u7d4c\u7d30\u80de\u306e\u4fe1\u53f7\u4f1d\u9054\u306e\u305f\u3081\u306e\u30a4\u30aa\u30f3\u5316\u57fa\u76e4\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib114\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib114\"><span class=\"anchor-text\">[114]<\/span><\/a>\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u640d\u50b7\u306f\u4e3b\u306b\u7570\u5e38\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u4ee3\u8b1d\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitochondrial-respiration\">\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u4ee3\u8b1d<\/a>\u00a0\u305d\u3057\u3066\u9178\u5316\u30c0\u30e1\u30fc\u30b8\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib115\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib115\"><span class=\"anchor-text\">[115]<\/span><\/a>\u3002\u7814\u7a76\u306b\u3088\u308a\u3001\u8133\u865a\u8840\u518d\u704c\u6d41\u640d\u50b7\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u4e0d\u5168\u3068\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib116\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib116\"><span class=\"anchor-text\">[116]<\/span><\/a>\u3002\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u9178\u5316\u640d\u50b7\u767a\u751f\u306e\u9375\u3067\u3042\u308a\u3001\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3068\u5bc6\u63a5\u306b\u95a2\u4fc2\u3057\u3066\u3044\u307e\u3059\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib117\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib117\"><span class=\"anchor-text\">[117]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib118\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib118\"><span class=\"anchor-text\">[118]<\/span><\/a>\u3002\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u8133\u7d44\u7e54\u640d\u50b7\u3001\u7279\u306b\u8133\u865a\u8840\u3084\u8133\u865a\u8840\u3067\u767a\u73fe\u3059\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u518d\u704c\u6d41\u969c\u5bb3\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/reperfusion-injury\">\u518d\u704c\u6d41\u50b7\u5bb3<\/a>\u00a0\u8133\u865a\u8840\u5f8c\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib119\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib119\"><span class=\"anchor-text\">[119]<\/span><\/a>\u3002\u4f53\u304c\u5916\u90e8\u304b\u3089\u306e\u6709\u5bb3\u7269\u8cea\u306e\u653b\u6483\u3092\u53d7\u3051\u308b\u3068\u3001\u7d30\u80de\u306f\u5927\u91cf\u306e\u6709\u5bb3\u7269\u8cea\u3092\u5206\u6ccc\u3057\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089 ROS \u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/reactive-oxygen-species\">ROS<\/a>\u00a0\u305d\u3057\u3066\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u6d3b\u6027\u70ad\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/activated-charcoal\">\u6d3b\u6027\u70ad<\/a>\u9178\u5316\u3068\u6297\u9178\u5316\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u5d29\u3057\u3001\u4e00\u9023\u306e\u9178\u5316\u640d\u50b7\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib120\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib120\"><span class=\"anchor-text\">[120]<\/span><\/a>ROS\u306e\u307b\u3068\u3093\u3069\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib121\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib121\"><span class=\"anchor-text\">[121]<\/span><\/a>\u3002\u5916\u90e8\u523a\u6fc0\u307e\u305f\u306f\u5185\u56e0\u6027\u640d\u50b7\u306b\u3088\u3063\u3066\u523a\u6fc0\u3055\u308c\u308b\u3068\u3001\u4f53\u306f\u9ad8\u30ec\u30d9\u30eb\u306e ROS \u3092\u8a98\u5c0e\u3057\u3001\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001NLRP3 \u3078\u306e\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306e\u7d50\u5408\u3092\u523a\u6fc0\u3057\u307e\u3059\u3002 ROS \u304c\u904e\u5270\u306b\u6d3b\u6027\u5316\u3059\u308b\u3068\u3001\u4f53\u5185\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u6b63\u5e38\u306a\u9806\u5e8f\u304c\u7834\u58ca\u3055\u308c\u3001\u305d\u306e\u7d50\u679c\u3001\u7d30\u80de\u5185\u306e\u907a\u4f1d\u7269\u8cea\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u304a\u3088\u3073\u3055\u307e\u3056\u307e\u306a\u7d30\u80de\u5c0f\u5668\u5b98 (\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u542b\u3080) \u304c\u7834\u58ca\u3055\u308c\u307e\u3059\u3002\u7d30\u80de\u5185\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306a\u3069\u306e\u3055\u307e\u3056\u307e\u306a\u7d30\u80de\u5c0f\u5668\u5b98\u304c\u640d\u50b7\u3059\u308b\u3068\u3001\u7d30\u80de\u306e\u6804\u990a\u3084\u4ee3\u8b1d\u306b\u7570\u5e38\u304c\u751f\u3058\u3001\u6d3b\u6027\u9178\u7d20\u304c\u7d30\u80de\u306e\u640d\u50b7\u3092\u3055\u3089\u306b\u60aa\u5316\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u8840\u7ba1\u5185\u76ae\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascular-endothelium\">\u8840\u7ba1\u5185\u76ae<\/a>\u00a0\u305d\u3057\u3066\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u5fae\u5c0f\u5faa\u74b0\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microcirculation\">\u5fae\u5c0f\u5faa\u74b0<\/a>\u00a0\u8133\u5185\u306e\u8840\u6db2\u8133\u95a2\u9580\u306e\u900f\u904e\u6027\u969c\u5bb3\u306f\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u7d30\u80de\u63a5\u7740\u5206\u5b50\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-adhesion-molecule\">\u7d30\u80de\u63a5\u7740\u5206\u5b50<\/a>\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u8133\u640d\u50b7\u3092\u60aa\u5316\u3055\u305b\u308b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib122\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib122\"><span class=\"anchor-text\">[122]<\/span><\/a>\u3002 \u305d\u306e\u9593\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/oxidative-stress\">\u9178\u5316\u30b9\u30c8\u30ec\u30b9<\/a>\u00a0\u7d30\u80de\u304c\u5f90\u3005\u306b\u5897\u52a0\u3059\u308b\u3053\u3068\u3092\u7279\u5fb4\u3068\u3059\u308b\u7d30\u80de\u6b7b\u30e2\u30fc\u30c9\u3092\u793a\u3059\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u7d30\u80de\u819c\u900f\u904e\u6027\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-membrane-permeability\">\u7d30\u80de\u819c\u900f\u904e\u6027<\/a>\u00a0\u7d30\u80de\u5185\u5bb9\u7269\u306e\u653e\u51fa - \u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib120\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib120\"><span class=\"anchor-text\">[120]<\/span><\/a>\u3057\u305f\u304c\u3063\u3066\u3001\u8133\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u306e\u75c5\u7406\u5b66\u7684\u904e\u7a0b\u306b\u306f\u3001\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u640d\u50b7\u306e\u4e21\u65b9\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u904b\u52d5\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8ceaDrp1\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u6b63\u5e38\u306a\u751f\u7406\u6a5f\u80fd\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u5fc5\u8981\u306a\u91cd\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib123\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib123\"><span class=\"anchor-text\">[123]<\/span><\/a>Drp1\u306e\u767a\u73fe\u304c\u5897\u52a0\u3059\u308b\u3068\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5206\u88c2\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitochondrial-fission\">\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5206\u88c2<\/a>\u00a0\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u30ec\u30d9\u30eb\u3092\u51e6\u7406\u3057\u3066\u4f4e\u4e0b\u3055\u305b\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u640d\u50b7\u306e\u767a\u751f\u3092\u9045\u3089\u305b\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib124\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib124\"><span class=\"anchor-text\">[124]<\/span><\/a>\u3002\u8eab\u4f53\u304c\u3055\u307e\u3056\u307e\u306a\u5185\u56e0\u6027\u304a\u3088\u3073\u5916\u56e0\u6027\u306e\u640d\u50b7\u523a\u6fc0\u3092\u53d7\u3051\u308b\u3068\u3001\u4f53\u5185\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u5236\u5fa1\u30d7\u30ed\u30bb\u30b9\u304c\u5909\u5316\u3057\u307e\u3059\u3002 Drp1\u306e\u5206\u6ccc\u4f4e\u4e0b\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u640d\u50b7\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u4e0d\u5168\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3084\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u5897\u52a0\u3068\u3057\u3066\u73fe\u308c\u3001\u4f53\u5185\u306e\u3055\u307e\u3056\u307e\u306a\u75be\u60a3\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib125\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib125\"><span class=\"anchor-text\">[125]<\/span><\/a>\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u4e0d\u5168\u304c\u8133\u865a\u8840\/\u518d\u704c\u6d41\u969c\u5bb3\u6642\u306bNLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u6d3b\u6027\u5316\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib126\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib126\"><span class=\"anchor-text\">[126]<\/span><\/a>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30bf\u30f3\u30d1\u30af\u8cea 2 \u306e\u8131\u5171\u5f79\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/uncoupling-protein-2\">\u8131\u5171\u5f79\u30bf\u30f3\u30d1\u30af\u8cea2<\/a>\u00a0UCP2 \u6b20\u640d\u306f CIRI \u5f8c\u306e\u8133\u640d\u50b7\u3092\u60aa\u5316\u3055\u305b\u3001\u65b0\u305f\u306a\u7814\u7a76\u3067\u306f\u3001UCP2 \u6b20\u640d\u304c\u3001in vitro \u304a\u3088\u3073 in vivo \u3067\u306e\u9ad8\u8840\u7cd6\u8a98\u767a\u6027 CIRI \u60aa\u5316\u5f8c\u306e NLRP3 \u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u6d3b\u6027\u5316\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002UCP2 \u306f\u3001\u9ad8\u8840\u7cd6\u8a98\u767a\u6027 CIRI \u60aa\u5316\u306e\u6f5c\u5728\u7684\u306a\u6cbb\u7642\u30bf\u30fc\u30b2\u30c3\u30c8\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002UCP2 \u6b20\u640d\u306f\u3001in vitro \u304a\u3088\u3073 in vivo \u3067\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\u306b\u304a\u3051\u308b NLRP3 \u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u6d3b\u6027\u5316\u3068 ROS \u751f\u6210\u3082\u4fc3\u9032\u3057\u307e\u3057\u305f\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib127\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib127\"><span class=\"anchor-text\">[127]<\/span><\/a>.\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30a2\u30c7\u30a3\u30dd\u30cd\u30af\u30c1\u30f3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/adiponectin\">\u30a2\u30c7\u30a3\u30dd\u30cd\u30af\u30c1\u30f3<\/a>\u00a0\u30a2\u30c7\u30a3\u30dd\u30cd\u30af\u30c1\u30f3\u306f\u3001\u5e45\u5e83\u3044\u6297\u9178\u5316\u4f5c\u7528\u3068\u6297\u708e\u75c7\u4f5c\u7528\u3092\u6301\u3064\u8102\u80aa\u7531\u6765\u30db\u30eb\u30e2\u30f3\u3067\u3059\u3002\u30a2\u30c7\u30a3\u30dd\u30cd\u30af\u30c1\u30f3\u30da\u30d7\u30c1\u30c9\u306f\u3001AMPK\/GSK-3\u03b2\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3067\u3001\u8133\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u5f8c\u306e\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u6d3b\u6027\u5316\u3092\u7de9\u548c\u3057\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib128\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib128\"><span class=\"anchor-text\">[128]<\/span><\/a>\u3002\u3057\u305f\u304c\u3063\u3066\u3001IS\u3067\u306f\u3001\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u767a\u751f\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u640d\u50b7\u306e\u9593\u306b\u5bc6\u63a5\u306a\u95a2\u4fc2\u304c\u3042\u308a\u3001\u4e21\u8005\u306e\u9593\u306b\u306f\u5bc6\u63a5\u306a\u76f8\u4e92\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<\/section>\n<section id=\"sec0060\">\n<h3 id=\"sect0080\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.7. \u9178\u5316\u30b9\u30c8\u30ec\u30b9\/\u30cb\u30c8\u30ed\u30bd\u5316\u30b9\u30c8\u30ec\u30b9\u306fIS\u5f8c\u306e\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u5a92\u4ecb\u3059\u308b<\/h3>\n<p id=\"p0100\">\u9178\u5316\/\u30cb\u30c8\u30ed\u30bd\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u795e\u7d4c\u708e\u75c7\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroinflammation\">\u795e\u7d4c\u708e\u75c7<\/a>\u00a0\u9375\u3067\u3059\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u75c5\u7406\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathological-process\">\u75c5\u7406\u5b66\u7684\u30d7\u30ed\u30bb\u30b9<\/a>\u00a0\u865a\u8840\u6027\u8133\u5352\u4e2d\u306b\u304a\u3051\u308b\u8133\u865a\u8840\u518d\u704c\u6d41\u640d\u50b7\u3001\u5a92\u4ecb\u30cb\u30e5\u30fc\u30ed\u30f3\u640d\u50b7\u3001\u8840\u6db2\u8133\u95a2\u9580\u640d\u50b7\u304a\u3088\u3073\u51fa\u8840\u6027\u5909\u5316\u306e\u7814\u7a76\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib129\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib129\"><span class=\"anchor-text\">[129]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib130\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib130\"><span class=\"anchor-text\">[130]<\/span><\/a>\u3002\u4e00\u9178\u5316\u7a92\u7d20\uff08NO\uff09\u3068\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30da\u30eb\u30aa\u30ad\u30b7\u4e9c\u785d\u9178\u5869\u306e\u8a73\u7d30\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/peroxynitrite\">\u30da\u30eb\u30aa\u30ad\u30b7\u4e9c\u785d\u9178\u5869<\/a>\u00a0(ONOO-) \u306f CIRI \u306e\u5178\u578b\u7684\u306a RNS \u3067\u3059\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib130\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib130\"><span class=\"anchor-text\">[130]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib131\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib131\"><span class=\"anchor-text\">[131]<\/span><\/a>3\u3064\u306e\u7570\u6027\u4f53\u304c\u3042\u308b\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u4e00\u9178\u5316\u7a92\u7d20\u30b7\u30f3\u30bf\u30fc\u30bc\u306e\u8a73\u7d30\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nitric-oxide-synthase\">\u4e00\u9178\u5316\u7a92\u7d20\u5408\u6210\u9175\u7d20<\/a>:\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u5185\u76ae\u4e00\u9178\u5316\u7a92\u7d20\u30b7\u30f3\u30bf\u30fc\u30bc\u306e\u8a73\u7d30\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/endothelial-nitric-oxide-synthase\">\u5185\u76ae\u4e00\u9178\u5316\u7a92\u7d20\u5408\u6210\u9175\u7d20<\/a>\u00a0\uff08eNOS\uff09\u306f\u4f4e\u6fc3\u5ea6\u306eNO\u3092\u751f\u6210\u3057\u3001\u751f\u7406\u5b66\u7684\u6a5f\u80fd\u3092\u6709\u3059\u308b\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u304c\u751f\u6210\u3057\u305f\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u3001\u795e\u7d4c\u7d30\u80de\u306e\u4e00\u9178\u5316\u7a92\u7d20\u30b7\u30f3\u30bf\u30fc\u30bc\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuronal-nitric-oxide-synthase\">\u795e\u7d4c\u578b\u4e00\u9178\u5316\u7a92\u7d20\u5408\u6210\u9175\u7d20<\/a>\u00a0(nNOS) \u304a\u3088\u3073\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u8a98\u5c0e\u6027\u4e00\u9178\u5316\u7a92\u7d20\u30b7\u30f3\u30bf\u30fc\u30bc\u306e\u8a73\u7d30\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inducible-nitric-oxide-synthase\">\u8a98\u5c0e\u6027\u4e00\u9178\u5316\u7a92\u7d20\u5408\u6210\u9175\u7d20<\/a>\u00a0(iNOS) \u9ad8\u6fc3\u5ea6\u306e NO \u3092\u751f\u6210\u3057\u3001\u708e\u75c7\u3092\u8a98\u767a\u3057\u3001\u8840\u6db2\u8133\u95a2\u9580\u306e\u900f\u904e\u6027\u3092\u9ad8\u3081\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib132\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib132\"><span class=\"anchor-text\">[132]<\/span><\/a>ROS\/RNS\u306e\u904e\u5270\u751f\u7523\u306f\u30b9\u30c8\u30ec\u30b9\u306e\u591a\u3044\u5fae\u5c0f\u74b0\u5883\u3092\u4f5c\u308a\u51fa\u3057\u3001\u4e00\u9023\u306e\u7d30\u80de\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30ab\u30b9\u30b1\u30fc\u30c9\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u708e\u75c7\u3001\u8840\u6db2\u8133\u95a2\u9580\u306e\u900f\u904e\u6027\u4ea2\u9032\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u8133\u6d6e\u816b\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-edema\">\u8133\u6d6e\u816b<\/a>\u00a0\u305d\u3057\u3066\u795e\u7d4c\u7d30\u80de\u6b7b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib133\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib133\"><span class=\"anchor-text\">[133]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib134\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib134\"><span class=\"anchor-text\">[134]<\/span><\/a>\u30da\u30eb\u30aa\u30ad\u30b7\u30ca\u30a4\u30c8\u30e9\u30a4\u30c8\u306f\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089 DNA \u9396\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/dna-strand\">DNA\u9396<\/a>\u00a0\u7834\u58ca\u3057\u6d3b\u6027\u5316\u3059\u308b\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30ea\u30dc\u30b6\u30a4\u30e0\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ribozyme\">\u30ea\u30dc\u30b6\u30a4\u30e0<\/a>\u00a0\u30dd\u30ea(ADP-\u30ea\u30dc\u30fc\u30b9)\u30b7\u30f3\u30bf\u30fc\u30bc(PARS)\u3001\u30dd\u30ea(ADP-\u30ea\u30dc\u30fc\u30b9)\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc(PARP)\u307e\u305f\u306f\u30dd\u30ea(ADP\u30ea\u30dc\u30fc\u30b9)\u3068\u3057\u3066\u3082\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/transferase\">\u8ee2\u79fb\u9175\u7d20<\/a>\u00a0(pADPRT)\u3002 ONOO - PARP \u3092\u76f4\u63a5\u30a2\u30af\u30c6\u30a3\u30d6\u5316\u3067\u304d\u307e\u3059\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib135\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib135\"><span class=\"anchor-text\">[135]<\/span><\/a>\u3001\u305d\u3057\u3066in vivo\u304a\u3088\u3073in vitro\u5b9f\u9a13\u306f\u3001\u865a\u8840\u6027\u8133\u640d\u50b7\u306b\u304a\u3051\u308bONOO-\/PARP\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u5f79\u5272\u3092\u5b9f\u8a3c\u3057\u305f\u3002in vivo\u5b9f\u9a13\u3067\u306f\u3001NOS\u6b20\u640d\u30de\u30a6\u30b9\u306f\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066PARP\u6d3b\u6027\u5316\u304c\u5c11\u306a\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002in vitro\u5b9f\u9a13\u3067\u306f\u3001\u57f9\u990aC6\u306b\u304a\u3044\u3066\u3001ONOO\u4f9b\u4e0e\u4f53\u306fPARP\u6d3b\u6027\u5316\u3092\u6709\u610f\u306b\u8a98\u5c0e\u3057\u305f\u304c\u3001NO\u4f9b\u4e0e\u4f53\u306f\u8a98\u5c0e\u3057\u306a\u304b\u3063\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u795e\u7d4c\u81a0\u816b\u7d30\u80de\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glioma-cell\">\u795e\u7d4c\u81a0\u816b\u7d30\u80de<\/a>.\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u907a\u4f1d\u5b50\u7834\u58ca\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/gene-disruption\">\u907a\u4f1d\u5b50\u7834\u58ca<\/a>\u00a0\u307e\u305f\u306fPARP\u306e\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u306f\u5927\u5e45\u306b\u6e1b\u5c11\u3057\u307e\u3059\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u8133\u6897\u585e\u306e\u30b5\u30a4\u30ba\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-infarction-size\">\u8133\u6897\u585e\u306e\u5927\u304d\u3055<\/a>\u3001\u7de9\u548c\u3059\u308b\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u795e\u7d4c\u6bd2\u6027\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neurotoxicity\">\u795e\u7d4c\u6bd2\u6027<\/a>\u795e\u7d4c\u8840\u7ba1\u30e6\u30cb\u30c3\u30c8\u3092\u4fdd\u8b77\u3057\u3001\u795e\u7d4c\u5b66\u7684\u8ee2\u5e30\u3092\u6539\u5584\u3057\u307e\u3059\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib136\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib136\"><span class=\"anchor-text\">[136]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib137\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib137\"><span class=\"anchor-text\">[137]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib138\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib138\"><span class=\"anchor-text\">[138]<\/span><\/a>\u7814\u7a76\u306b\u3088\u308a\u3001ROS\/RNS\u306fCIRI\u4e2d\u306e\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u6d3b\u6027\u5316\u56e0\u5b50\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u305f\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib139\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib139\"><span class=\"anchor-text\">[139]<\/span><\/a>\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306f\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u7d30\u80de\u8cea\u306b\u5b58\u5728\u3059\u308b\u591a\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u3067\u3001\u305d\u306e\u4e2d\u3067\u6700\u3082\u5e83\u304f\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u306e\u306fNOD\u69d8\u53d7\u5bb9\u4f533\uff08NLRP3\uff09\u3067\u3042\u308b\u3002NLRP3\u306f\u30ab\u30b9\u30d1\u30fc\u30bc1\u3092\u8a98\u767a\u3057\u3066\u6d3b\u6027\u5316\u3057\u3001IL-1\u03b2\u3068IL-18\u3092\u6d3b\u6027\u5316\u3057\u3066\u305d\u308c\u3089\u3092\u7d30\u80de\u5185\u306b\u653e\u51fa\u3059\u308b\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u7d30\u80de\u5916\u7a7a\u9593\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/extracellular-space\">\u7d30\u80de\u5916\u7a7a\u9593<\/a>\u3001\u708e\u75c7\u306e\u9032\u884c\u3092\u4fc3\u9032\u3059\u308b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib140\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib140\"><span class=\"anchor-text\">[140]<\/span><\/a>\u751f\u4f53\u5185\u5b9f\u9a13\u3067\u306f\u3001NLPR3\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u306e\u8133\u6897\u585e\u306e\u5927\u304d\u3055\u3068BBB\u306e\u640d\u50b7\u306f\u91ce\u751f\u578b\u30de\u30a6\u30b9\u3088\u308a\u3082\u4f4e\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u3055\u3089\u306b\u5b9f\u9a13\u3067\u306f\u3001NLRP3\u304cIL-1\u03b2\u306e\u653e\u51fa\u3092\u5a92\u4ecb\u3057\u3001\u8133\u5fae\u5c0f\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u900f\u904e\u6027\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib141\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib141\"><span class=\"anchor-text\">[141]<\/span><\/a>\u6838\u56e0\u5b50E2\u95a2\u9023\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u56e0\u5b50 2 \u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/prothrombin\">\u8981\u56e02<\/a>\u00a0(Nrf2) \u306f\u7d30\u80de\u306e\u6297\u9178\u5316\u53cd\u5fdc\u3092\u8abf\u7bc0\u3057\u3001Nrf2 \u306f\u9178\u7d20\u304a\u3088\u3073\u30b0\u30eb\u30b3\u30fc\u30b9\u6b20\u4e4f\u6761\u4ef6\u4e0b\u3067 BV2 \u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306b\u304a\u3051\u308b ROS \u5a92\u4ecb NLRP3 \u7523\u751f\u3092\u963b\u5bb3\u3057\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib142\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib142\"><span class=\"anchor-text\">[142]<\/span><\/a>\u3002\u9178\u5316\/\u30cb\u30c8\u30ed\u30bd\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u30da\u30eb\u30aa\u30ad\u30b7\u4e9c\u785d\u9178\u5869\u306e\u5f62\u6210\u3092\u8a98\u5c0e\u3057\u3001\u3053\u308c\u304c\u30ab\u30b9\u30d1\u30fc\u30bc1\/\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u6d3b\u6027\u5316\u306e\u91cd\u8981\u306a\u30c8\u30ea\u30ac\u30fc\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3057\u305f\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib143\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib143\"><span class=\"anchor-text\">[143]<\/span><\/a>\u3057\u305f\u304c\u3063\u3066\u3001ROS\/RNS\u5a92\u4ecb\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306f\u865a\u8840\u6027\u8133\u969c\u5bb3\u306e\u6f5c\u5728\u7684\u306a\u6cbb\u7642\u6a19\u7684\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/p>\n<p id=\"p0105\">\u3055\u3089\u306b\u3001ROS\/RNS \u306f\u3001Toll \u69d8\u53d7\u5bb9\u4f53\u306e\u6d3b\u6027\u5316\u3092\u4ef2\u4ecb\u3057\u307e\u3059\u3002\u73fe\u5728\u306e\u7814\u7a76\u3067\u306f\u3001Toll \u69d8\u53d7\u5bb9\u4f53 (TLR) \u304c\u5148\u5929\u6027\u53d7\u5bb9\u4f53\u3068\u3057\u3066\u5e83\u304f\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u514d\u75ab\u53d7\u5bb9\u4f53\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immune-system-receptors\">\u514d\u75ab\u53d7\u5bb9\u4f53<\/a>\u3001TLR4\/2\u306f\u8133\u3067\u3088\u308a\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u865a\u8840\u6027\u969c\u5bb3\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemic-injury\">\u865a\u8840\u6027\u640d\u50b7<\/a>.\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089 TLR4 \u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/toll-like-receptor-4\">TLR4<\/a>\u00a0IL-1\u03b2\u3001MMP-9\u3001iNOS\u3001COX-2\u306e\u767a\u73fe\u3092\u5a92\u4ecb\u3057\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u8133\u969c\u5bb3\u3092\u60aa\u5316\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib144\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib144\"><span class=\"anchor-text\">[144]<\/span><\/a>\u3002 TLR4\u963b\u5bb3\u5264\u306e\u9069\u7528\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089E5564\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/eritoran\">E5564<\/a>\u00a0\u305d\u308c\u306f\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u795e\u7d4c\u4fdd\u8b77\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroprotective-agent\">\u795e\u7d4c\u4fdd\u8b77<\/a>\u00a0\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u6d3b\u6027\u5316\u3068ROS\u306e\u751f\u6210\u3092\u963b\u5bb3\u3059\u308b\u5f79\u5272\u3092\u679c\u305f\u3059\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib145\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib145\"><span class=\"anchor-text\">[145]<\/span><\/a>\u3002 IS\u5f8c\u3001TLR4\u6b20\u640d\u30de\u30a6\u30b9\u306e\u6897\u585e\u30b5\u30a4\u30ba\u306f\u91ce\u751f\u578b\u30de\u30a6\u30b9\u306e\u6897\u585e\u30b5\u30a4\u30ba\u3088\u308a\u3082\u6709\u610f\u306b\u5c0f\u3055\u304b\u3063\u305f\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib146\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib146\"><span class=\"anchor-text\">[146]<\/span><\/a>\u3002 TLR4\u306f\u30dd\u30b9\u30c8IS\u306b\u3082\u95a2\u4e0e\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u795e\u7d4c\u65b0\u751f\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neurogenesis\">\u795e\u7d4c\u65b0\u751f<\/a>.\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u967d\u96fb\u5b50\u653e\u51fa\u65ad\u5c64\u64ae\u5f71\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/positron-emission-tomography\">\u967d\u96fb\u5b50\u653e\u51fa\u65ad\u5c64\u64ae\u5f71<\/a>\u00a0\u7814\u7a76\u3067\u306f\u3001TLR4\u6b20\u640d\u30de\u30a6\u30b9\u304cIS\u306b\u304a\u3051\u308b\u795e\u7d4c\u65b0\u751f\u3092\u4fc3\u9032\u3057\u3001\u708e\u75c7\u53cd\u5fdc\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib147\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib147\"><span class=\"anchor-text\">[147]<\/span><\/a>\u3002\u3055\u3089\u306b\u3001in vivo \u5b9f\u9a13\u7814\u7a76\u3067\u306f\u3001TLR2\/4\/NF-\u03baB \u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u963b\u5bb3\u304c\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3001\u708e\u75c7\u53cd\u5fdc\u306e\u8abf\u7bc0\u3001\u865a\u8840\u6027\u8133\u7d44\u7e54\u306e\u4fdd\u8b77\u306b\u4e00\u5b9a\u306e\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib148\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib148\"><span class=\"anchor-text\">[148]<\/span><\/a>\u3057\u305f\u304c\u3063\u3066\u3001TLR4\/2\u306f\u865a\u8840\u6027\u8133\u969c\u5bb3\u306e\u6cbb\u7642\u6a19\u7684\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/p>\n<\/section>\n<\/section>\n<section id=\"sec0065\">\n<h2 id=\"sect0085\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">3. \u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3068IS\u306e\u95a2\u4fc2<\/h2>\n<p id=\"p0110\">\u8133\u306e\u75c5\u7406\u5b66\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u865a\u8840\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemia\">\u865a\u8840<\/a>\u00a0\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u306f\u8907\u96d1\u3067\u3042\u308b\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u95a2\u4e0e\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u306f\u3001\u708e\u75c7\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u4e0d\u5168\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u904e\u8ca0\u8377\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u7d30\u80de\u6b7b\u306a\u3069\u304c\u3042\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib149\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib149\"><span class=\"anchor-text\">[149]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib150\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib150\"><span class=\"anchor-text\">[150]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib151\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib151\"><span class=\"anchor-text\">[151]<\/span><\/a>\u3002\u30d7\u30ed\u30b0\u30e9\u30e0\u3055\u308c\u305f\u7d30\u80de\u6b7b\u304c\u8133\u865a\u8840\u304a\u3088\u3073\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u306e\u75c5\u7406\u5b66\u7684\u904e\u7a0b\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u304a\u308a\u3001\u4e0a\u8a18\u306e\u6a5f\u69cb\u3001\u7279\u306b\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3068\u7d61\u307f\u5408\u3063\u3066\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u3001\u591a\u304f\u306e\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib152\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib152\"><span class=\"anchor-text\">[152]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib153\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib153\"><span class=\"anchor-text\">[153]<\/span><\/a>\u30d7\u30ed\u30b0\u30e9\u30e0\u7d30\u80de\u6b7b\u306f\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u4e3b\u306a\u4e8b\u8c61\u3067\u3042\u308a\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microglia\">\u30df\u30af\u30ed\u30b0\u30ea\u30a2<\/a>\u3001\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascular-endothelial-cell\">\u8840\u7ba1\u5185\u76ae\u7d30\u80de<\/a>\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306a\u3069\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib154\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib154\"><span class=\"anchor-text\">[154]<\/span><\/a>\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib155\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib155\"><span class=\"anchor-text\">[155]<\/span><\/a>\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u3055\u308c\u305f\u58ca\u6b7b\u307e\u305f\u306f\u58ca\u6b7b\u75c7\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib156\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib156\"><span class=\"anchor-text\">[156]<\/span><\/a>,\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30d5\u30a7\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ferroptosis\">\u30d5\u30a7\u30ed\u30c8\u30fc\u30b7\u30b9<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib157\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib157\"><span class=\"anchor-text\">[157]<\/span><\/a>\u3001\u304a\u3088\u3073\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib158\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib158\"><span class=\"anchor-text\">[158]<\/span><\/a>\u7279\u306b\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3067\u306f\u3001\u30e9\u30c3\u30c8\u306e\u8133\u865a\u8840\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066NLRP1\u3001ASC\u3001\u30ab\u30b9\u30d1\u30fc\u30bc1\u3001GSDMD\u306a\u3069\u306e\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u304c\u5897\u52a0\u3057\u3066\u304a\u308a\u3001NLRP1\u306e\u963b\u5bb3\u306f\u708e\u75c7\u3084\u8133\u969c\u5bb3\u3092\u8efd\u6e1b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u865a\u8840\u6027\u969c\u5bb3\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemic-injury\">\u865a\u8840\u6027\u640d\u50b7<\/a>\u3002\u3055\u3089\u306b\u3001\u6162\u6027\u8133\u865a\u8840\u306e\u5834\u5408\u3001\u7d30\u80de\u306f DAMP \u3084\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089 PAMP \u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathogen-associated-molecular-pattern\">PAMPs<\/a>\u3001\u305d\u3057\u3066\u4e00\u9023\u306e\u8907\u96d1\u306a\u5206\u5b50\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u3053\u306e\u3068\u304d\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3084\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306a\u3069\u306e\u982d\u84cb\u5185\u795e\u7d4c\u514d\u75ab\u708e\u75c7\u7d30\u80de\u304c\u5897\u6b96\u3057\u3066\u6d3b\u6027\u5316\u3057\u3001\u795e\u7d4c\u8840\u7ba1\u5358\u4f4d\u306b\u3055\u3089\u306b\u640d\u50b7\u3092\u4e0e\u3048\u308b\u3088\u3046\u3067\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib159\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib159\"><span class=\"anchor-text\">[159]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib160\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib160\"><span class=\"anchor-text\">[160]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib161\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib161\"><span class=\"anchor-text\">[161]<\/span><\/a>.<\/p>\n<section id=\"sec0070\">\n<h3 id=\"sect0090\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">3.1. \u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3068\u30cb\u30e5\u30fc\u30ed\u30f3<\/h3>\n<p id=\"p0115\">IS\u5f8c\u306f\u77ed\u6642\u9593\u3067\u865a\u8840\u4e2d\u5fc3\u90e8\u306b\u58ca\u6b7b\u304c\u8d77\u3053\u308a\u3001\u6b7b\u3093\u3060\u7d30\u80de\u304c\u6b21\u306e\u3088\u3046\u306a\u5371\u967a\u4fe1\u53f7\u3092\u767a\u3057\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089 HMGB1 \u30bf\u30f3\u30d1\u30af\u8cea\u306e\u8a73\u7d30\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/high-mobility-group-b1-protein\">HMGB1\u30bf\u30f3\u30d1\u30af\u8cea<\/a>,\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/heat-shock-protein\">\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3<\/a>,\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30da\u30eb\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/peroxidase\">\u30da\u30eb\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc<\/a>\u00a0\u30d5\u30a1\u30df\u30ea\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u306a\u3069\u3002\u3053\u308c\u3089\u306e\u5371\u967a\u4fe1\u53f7\u5206\u5b50\u306f\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30d1\u30bf\u30fc\u30f3\u8a8d\u8b58\u53d7\u5bb9\u4f53\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pattern-recognition-receptor\">\u30d1\u30bf\u30fc\u30f3\u8a8d\u8b58\u53d7\u5bb9\u4f53<\/a>\u3001 \u5f62\u72b6\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammasome\">\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0<\/a>\u3001\u81ea\u7136\u514d\u75ab\u53cd\u5fdc\u3092\u958b\u59cb\u3057\u3001\u795e\u7d4c\u7d30\u80de\u6b7b\u3092\u5f15\u304d\u8d77\u3053\u3059\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib162\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib162\"><span class=\"anchor-text\">[162]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib163\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib163\"><span class=\"anchor-text\">[163]<\/span><\/a>\u7814\u7a76\u306b\u3088\u308a\u3001\u8133\u865a\u8840\u306fNLRP1\u306e\u9ad8\u767a\u73fe\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308a\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089 NLRP3 \u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nucleotide-binding-oligomerization-domain-like-receptor\">NLRP3<\/a>\u00a0\u865a\u8840\u6027\u8133\u7d44\u7e54\u304a\u3088\u3073\u30cb\u30e5\u30fc\u30ed\u30f3\u306b\u304a\u3044\u3066\u3001NLRP1\u306e\u6d3b\u6027\u5316\u306f\u4e3b\u306b\u30cb\u30e5\u30fc\u30ed\u30f3\u306b\u5b58\u5728\u3059\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib164\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib164\"><span class=\"anchor-text\">[164]<\/span><\/a>\u3002\u30ab\u30b9\u30d1\u30fc\u30bc-1 \u963b\u5bb3\u5264\u307e\u305f\u306f\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\u88fd\u5264\u3092\u4f7f\u7528\u3059\u308b\u3068\u3001\u4e00\u6b21\u76ae\u8cea\u30cb\u30e5\u30fc\u30ed\u30f3\u306b\u304a\u3051\u308b NLRP1 \u304a\u3088\u3073 NLRP3 \u306e\u767a\u73fe\u304c\u6e1b\u5f31\u3057\u3001\u795e\u7d4c\u7d30\u80de\u306e\u30b5\u30a4\u30ba\u304c\u7e2e\u5c0f\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u8133\u6897\u585e\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-infarction\">\u8133\u6897\u585e<\/a>\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306fNF-\u03baB\u3068MAPK\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u306e\u963b\u5bb3\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib164\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib164\"><span class=\"anchor-text\">[164]<\/span><\/a>IS\u30de\u30a6\u30b9\u3067\u306fLi et al.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib165\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib165\"><span class=\"anchor-text\">[165]<\/span><\/a>\u00a0\u8133\u865a\u8840\u5f8c3\u65e5\u76ee\u306b\u3001\u795e\u7d4c\u7d30\u80de\u8cea\u3001\u6838\u3001\u304a\u3088\u3073\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u819c\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitochondrial-membrane\">\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u819c<\/a>\u00a0\u304c\u8d77\u3053\u308a\u3001Caspase-1\u3001GSDMD\u3001IL-1\u03b2\u306e\u767a\u73fe\u304c\u6709\u610f\u306b\u5897\u52a0\u3057\u307e\u3057\u305f\u3002\u30ab\u30b9\u30d1\u30fc\u30bc-1\u963b\u5bb3\u5264\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089 Vx765 \u306e\u8a73\u7d30\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/belnacasan\">\uff36\uff38\uff17\uff16\uff15<\/a>\u00a0\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3092\u6291\u5236\u3057\u3001\u865a\u8840\u90e8\u4f4d\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u751f\u5b58\u3092\u4fc3\u9032\u3057\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u8133\u6a5f\u80fd\u969c\u5bb3\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-dysfunction\">\u8133\u6a5f\u80fd\u969c\u5bb3<\/a>\u00a0\u30de\u30a6\u30b9\u306b\u304a\u3044\u3066\u3002Liang et al.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib166\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib166\"><span class=\"anchor-text\">[166]<\/span><\/a>\u00a0\u306f\u3001\u9577\u3044\u975e\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0 RNA \u6bcd\u6027\u767a\u73fe\u907a\u4f1d\u5b50 3 (MEG3) \u304c\u3001AIM2\/\u30ab\u30b9\u30d1\u30fc\u30bc-1 \u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3068\u708e\u75c7\u53cd\u5fdc\u3092\u4fc3\u9032\u3057\u3001\u8133\u865a\u8840\u518d\u704c\u6d41\u50b7\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002 MEG3 \u907a\u4f1d\u5b50\u3092\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u3059\u308b\u3068\u3001\u6b21\u306e\u3088\u3046\u306a\u767a\u73fe\u304c\u963b\u5bb3\u3055\u308c\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089 AIM2 \u306e\u8a73\u7d30\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nodular-melanoma\">\u30a8\u30a4\u30e02<\/a>\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3001GSMDD \u304a\u3088\u3073\u305d\u306e\u4ed6\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u865a\u8840\u6027\u8133\u640d\u50b7\u3092\u8efd\u6e1b\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u3001MEG3 \u304c\u865a\u8840\u6027\u8133\u5352\u4e2d\u306b\u5bfe\u3059\u308b\u52b9\u679c\u7684\u306a\u6cbb\u7642\u6a19\u7684\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/section>\n<section id=\"sec0075\">\n<h3 id=\"sect0095\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">3.2. \u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3068\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8<\/h3>\n<p id=\"p0120\">\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u304c\u6700\u3082\u8c4a\u5bcc\u3067\u3059\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30b0\u30ea\u30a2\u7d30\u80de\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glial-cells\">\u30b0\u30ea\u30a2\u7d30\u80de<\/a>\u00a0\u306e\u4e2d\u306b\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/central-nervous-system\">\u4e2d\u67a2\u795e\u7d4c\u7cfb<\/a>\u00a0\u8840\u6db2\u8133\u95a2\u9580\u306e\u5f62\u6210\u306b\u95a2\u4e0e\u3057\u3001\u795e\u7d4c\u7d30\u80de\u306e\u4ee3\u8b1d\u3092\u8abf\u7bc0\u3057\u3001\u7d30\u80de\u9593\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u3092\u5b89\u5b9a\u5316\u3055\u305b\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib167\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib167\"><span class=\"anchor-text\">[167]<\/span><\/a>IS\u5f8c\u3001\u9855\u8457\u306a\u75c5\u7406\u5b66\u7684\u5909\u5316\u306f\u53cd\u5fdc\u6027\u3067\u3042\u308b\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30a2\u30b9\u30c8\u30ed\u30b0\u30ea\u30aa\u30fc\u30b7\u30b9\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/astrocytosis\">\u30a2\u30b9\u30c8\u30ed\u30b0\u30ea\u30a2\u75c7<\/a>\u00a0\u30b0\u30ea\u30a2\u7d30\u80de\u306e\u7622\u75d5\u5316\u306f\u865a\u8840\u6027\u969c\u5bb3\u306e\u65e9\u671f\u306b\u795e\u7d4c\u53ef\u5851\u6027\u3092\u4fc3\u9032\u3059\u308b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib168\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib168\"><span class=\"anchor-text\">[168]<\/span><\/a>\u4e00\u822c\u7684\u306b\u306f\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u6d77\u99ac\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hippocampus\">\u6d77\u99ac<\/a>\u00a0\u865a\u8840\u3067\u3042\u308a\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u4f4e\u9178\u7d20\u75c7\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hypoxia\">\u4f4e\u9178\u7d20\u75c7<\/a>\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u6297\u9178\u5316\u80fd\u529b\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antioxidant-capacity\">\u6297\u9178\u5316\u529b<\/a>\u00a0\u6d77\u99ac\u306e\u6a5f\u80fd\u304c\u5f31\u307e\u308a\u3001\u708e\u75c7\u56e0\u5b50\u304c\u5927\u91cf\u306b\u653e\u51fa\u3055\u308c\u3001\u6d77\u99ac\u306e\u640d\u50b7\u304c\u60aa\u5316\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib169\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib169\"><span class=\"anchor-text\">[169]<\/span><\/a>\u3002\u5c40\u6240\u8133\u865a\u8840\u304b\u3089 3 \u6642\u9593\u5f8c\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089 SD \u30e9\u30c3\u30c8\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/sprague-dawley-rat\">SD\u30e9\u30c3\u30c8<\/a>\u865a\u8840\u90e8\u4f4d\u306b\u306fIL-1\u03b2\u69d8\u514d\u75ab\u53cd\u5fdc\u967d\u6027\u7d30\u80de\u304c\u51fa\u73fe\u3057\u3001\u4e3b\u306b\u4e0d\u6d3b\u6027\u5316\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3067\u3042\u3063\u305f\u3002\u865a\u8840\u5f8c2\u30f6\u6708\u307e\u3067\u3001\u967d\u6027\u7d30\u80de\u306f\u865a\u8840\u534a\u7403\u3001\u7279\u306b\u58ca\u6b7b\u5de3\u306e\u5468\u56f2\u3067\u691c\u51fa\u3055\u308c\u3001\u6d3b\u6027\u5316\u306e\u7a0b\u5ea6\u304c\u9ad8\u3044\u307b\u3069\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib170\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib170\"><span class=\"anchor-text\">[170]<\/span><\/a>\u6d3b\u6027\u5316\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306f\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u816b\u760d\u58ca\u6b7b\u56e0\u5b50\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tumor-necrosis-factor\">\u816b\u760d\u58ca\u6b7b\u56e0\u5b50<\/a>\u3001\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3\u3001\u6210\u9577\u56e0\u5b50\u3001\u305d\u306e\u4ed6\u306e\u708e\u75c7\u56e0\u5b50\u307e\u305f\u306f\u795e\u7d4c\u6bd2\u6027\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u306b\u3088\u308a\u3001\u795e\u7d4c\u640d\u50b7\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib171\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib171\"><span class=\"anchor-text\">[171]<\/span><\/a>NLRP2\u306f\u4e3b\u306b\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3067\u767a\u73fe\u3057\u3066\u3044\u308b\u304c\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u3084\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3067\u306f\u307b\u3068\u3093\u3069\u767a\u73fe\u3057\u3066\u3044\u306a\u3044\u3002\u3055\u3089\u306b\u3001\u30de\u30a6\u30b9\u8133\u865a\u8840\u30e2\u30c7\u30eb\u3084\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3067\u306e\u9178\u7d20\u304a\u3088\u3073\u30b0\u30eb\u30b3\u30fc\u30b9\u6b20\u4e4f\u5f8c\u306bNLRP2\u306e\u767a\u73fe\u304c\u8457\u3057\u304f\u4e0a\u6607\u3057\u3001NLRP2\u3092\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u3059\u308b\u3068\u9178\u7d20\u304a\u3088\u3073\u30b0\u30eb\u30b3\u30fc\u30b9\u6b20\u4e4f\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3092\u8efd\u6e1b\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib172\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib172\"><span class=\"anchor-text\">[172]<\/span><\/a>\u3002\u5225\u306e\u7814\u7a76\u3067\u306f\u3001\u8133\u865a\u8840\u306e in vitro \u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001\u9178\u7d20\u30b0\u30eb\u30b3\u30fc\u30b9\u6b20\u4e4f\u306b\u3088\u308a NLRP3\u3001ASC\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3001IL-1\u03b2\u3001\u304a\u3088\u3073 IL-18 \u304c\u5897\u52a0\u3057\u3001\u661f\u72b6\u7d30\u80de\u306e\u751f\u5b58\u304c\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30d2\u30b9\u30d4\u30c9\u30a5\u30ea\u30f3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hispidulin\">\u30d2\u30b9\u30d4\u30c9\u30ea\u30f3<\/a>\u00a0\u304b\u3089\u5358\u96e2\u3055\u308c\u305f\u30b1\u30c8\u30f3\u5316\u5408\u7269\u3067\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u6f22\u65b9\u85ac\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chinese-herbal-medicine\">\u6f22\u65b9\u85ac<\/a>\u3002 in vitro \u304a\u3088\u3073 in vivo \u5b9f\u9a13\u3067\u306f\u3001\u30d2\u30b9\u30d4\u30b8\u30e5\u30ea\u30f3\u304c NLRP3 \u5a92\u4ecb\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u963b\u5bb3\u3057\u3001\u8133\u306b\u4fdd\u8b77\u52b9\u679c\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u3067\u304d\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f AMPK\/GSK-3\u03b2 \u306e\u6d3b\u6027\u5316\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/signal-transduction\">\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib173\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib173\"><span class=\"anchor-text\">[173]<\/span><\/a>\u3002 Meng\u3089\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib174\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib174\"><span class=\"anchor-text\">[174]<\/span><\/a>\u00a0NLRP6 \u306e\u767a\u73fe\u306f\u3001\u30e9\u30c3\u30c8\u306e\u8133\u865a\u8840\u518d\u704c\u6d41\u5f8c 48 \u6642\u9593\u3067\u30d4\u30fc\u30af\u306b\u9054\u3059\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3067\u9178\u7d20\u3068\u30b0\u30eb\u30b3\u30fc\u30b9\u304c\u6b20\u4e4f\u3059\u308b\u3068\u3001NLRP6 \u3068\u305d\u306e\u6d3b\u6027\u5316\u7523\u7269\u306e\u7523\u751f\u304c\u5897\u52a0\u3057\u3001NLRP6 \u3092\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u3059\u308b\u3068 ASC \u3068\u30ab\u30b9\u30d1\u30fc\u30bc 1 \u304c\u6e1b\u5c11\u3057\u3001\u708e\u75c7\u56e0\u5b50\u306e\u653e\u51fa\u304c\u6e1b\u5c11\u3057\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u6d3b\u52d5\u304c\u5897\u52a0\u3057\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib175\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib175\"><span class=\"anchor-text\">[175]<\/span><\/a>\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u661f\u72b6\u7d30\u80de\u306b\u304a\u3051\u308b\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u6d3b\u6027\u5316\u3092\u6a19\u7684\u3068\u3057\u305f\u4ecb\u5165\u306f\u3001IS \u306e\u6cbb\u7642\u306b\u65b0\u3057\u3044\u30a2\u30a4\u30c7\u30a2\u3092\u63d0\u4f9b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<\/section>\n<section id=\"sec0080\">\n<h3 id=\"sect0100\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">3.3. \u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3068\u30df\u30af\u30ed\u30b0\u30ea\u30a2<\/h3>\n<p id=\"p0125\">\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306f\u5148\u5929\u7684\u306b\u5b58\u5728\u3059\u308b\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u514d\u75ab\u7d30\u80de\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunocompetent-cell\">\u514d\u75ab\u7d30\u80de<\/a>\u00a0\u4e2d\u67a2\u795e\u7d4c\u7cfb\u3068\u865a\u8840\u6027\u8133\u5352\u4e2d\u5f8c\u306b\u6700\u3082\u65e9\u304f\u6d3b\u6027\u5316\u3059\u308b\u7d30\u80de\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib176\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib176\"><span class=\"anchor-text\">[176]<\/span><\/a>\u3002\u8133\u865a\u8840\u640d\u50b7\u306e\u6025\u6027\u671f\u3067\u306f\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u304c\u6025\u901f\u306b\u75c5\u5909\u90e8\u4f4d\u306b\u79fb\u52d5\u3057\u3001\u708e\u75c7\u56e0\u5b50\u3084\u7d30\u80de\u50b7\u5bb3\u6027\u7269\u8cea\u3092\u5206\u6ccc\u3057\u3001\u7d44\u7e54\u640d\u50b7\u3092\u60aa\u5316\u3055\u305b\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib177\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib177\"><span class=\"anchor-text\">[177]<\/span><\/a>\u3002\u6162\u6027\u671f\u3067\u306f\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306f\u6297\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u6210\u9577\u56e0\u5b50\u3092\u751f\u6210\u3057\u3066\u708e\u75c7\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u7d44\u7e54\u4fee\u5fa9\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tissue-repair\">\u7d44\u7e54\u4fee\u5fa9<\/a>\u00a0\u304a\u3088\u3073\u30ea\u30d5\u30a9\u30fc\u30e0\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib178\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib178\"><span class=\"anchor-text\">[178]<\/span><\/a>\u3002\u7814\u7a76\u306b\u3088\u308a\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u304c\u865a\u8840\u6027\u8133\u640d\u50b7\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002 NLRC4\u306f\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u304c\u9178\u7d20\u3068\u30b0\u30eb\u30b3\u30fc\u30b9\u30923\u6642\u9593\u6b20\u4e4f\u3055\u305b\u305f\u3068\u304d\u306b\u6709\u610f\u306b\u5897\u52a0\u3057\u305f\u6700\u521d\u306e\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u3067\u3042\u3063\u305f\u304c\u3001NLRP1\u3001NLRP3\u3001\u304a\u3088\u3073AIM2\u306f\u3001\u9178\u7d20\u30b0\u30eb\u30b3\u30fc\u30b9\u6b20\u4e4f\u306e6\u6642\u9593\u5f8c\u307e\u3067\u6709\u610f\u306b\u5897\u52a0\u3057\u306a\u304b\u3063\u305f\u3002 NLRC4 \u3092\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u3059\u308b\u3068\u3001GSDMD\u3001IL-1\u03b2\u3001IL-18 \u306e\u7523\u751f\u304c\u6e1b\u5c11\u3057\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u304c\u6291\u5236\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib179\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib179\"><span class=\"anchor-text\">[179]<\/span><\/a>\u3002 Xu \u3089\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib180\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib180\"><span class=\"anchor-text\">[180]<\/span><\/a>\u00a0\u30c9\u30e9\u30a4\u30d0\u30fc\u53d7\u5bb9\u4f531\uff08TREM-1\uff09\u306f\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u9aa8\u9ac4\u7d30\u80de\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/myeloid-cell\">\u9aa8\u9ac4\u7d30\u80de<\/a>\u00a0\u8133\u865a\u8840\u518d\u704c\u6d41\u5f8c\u306e\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306b\u304a\u3051\u308bTREM-1\u306e\u767a\u73fe\u306f\u3001NLRP3\/\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3092\u4ecb\u3057\u305f\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3057\u3001\u795e\u7d4c\u708e\u75c7\u53cd\u5fdc\u3092\u8a98\u767a\u3059\u308b\u3002TREM-1\u306e\u963b\u5bb3\u306f\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3068\u795e\u7d4c\u640d\u50b7\u3092\u8efd\u6e1b\u3059\u308b\u3002Li et al.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib181\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib181\"><span class=\"anchor-text\">[181]<\/span><\/a>\u00a0\u74b0\u72b6\u30b0\u30a2\u30ce\u30b7\u30f3\u4e00\u30ea\u30f3\u9178\u30a2\u30c7\u30ce\u30b7\u30f3\u5408\u6210\u9175\u7d20 (cGAS) \u306e\u767a\u73fe\u304c\u8133\u865a\u8840\u5f8c\u306b\u4e0a\u65b9\u5236\u5fa1\u3055\u308c\u3001AIM2 \u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u3092\u6d3b\u6027\u5316\u3057\u3066\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002 cGAS \u30a2\u30f3\u30bf\u30b4\u30cb\u30b9\u30c8 A151 \u306f\u3001AIM2 \u6d3b\u6027\u5316\u3068\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u963b\u5bb3\u3057\u3001\u8133\u6897\u585e\u4f53\u7a4d\u3092\u5927\u5e45\u306b\u6e1b\u5c11\u3055\u305b\u3001\u795e\u7d4c\u640d\u50b7\u3092\u8efd\u6e1b\u3057\u307e\u3059\u3002\u4e0a\u8a18\u306e\u7814\u7a76\u306f\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3068\u305d\u306e\u5a92\u4ecb\u6027\u795e\u7d4c\u708e\u75c7\u53cd\u5fdc\u304c\u865a\u8840\u6027\u8133\u640d\u50b7\u3092\u5f15\u304d\u8d77\u3053\u3059\u91cd\u8981\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u795e\u7d4c\u6bd2\u6027\u4f5c\u7528\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u306f\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u6cbb\u7642\u306e\u65b0\u3057\u3044\u6226\u7565\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<\/section>\n<section id=\"sec0085\">\n<h3 id=\"sect0105\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">3.4.\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3068\u5185\u76ae\u7d30\u80de<\/h3>\n<p id=\"p0130\">\u5185\u76ae\u7d30\u80de\u306f\u8840\u6db2\u8133\u95a2\u9580\u306e\u6700\u521d\u306e\u95a2\u9580\u3092\u69cb\u6210\u3057\u3001\u8840\u6db2\u8133\u95a2\u9580\u306e\u8db3\u5834\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30af\u30ed\u30fc\u30c7\u30a3\u30f3\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/claudin\">\u30af\u30ed\u30fc\u30c7\u30a3\u30f3<\/a>,\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u63a5\u7740\u5206\u5b50\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-adhesion-molecule\">\u63a5\u7740\u5206\u5b50<\/a>\u00a0\u305d\u3057\u3066\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/extracellular-matrix\">\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib182\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib182\"><span class=\"anchor-text\">[182]<\/span><\/a>\u3002\u8133\u865a\u8840\u4e2d\u3001\u514d\u75ab\u708e\u75c7\u53cd\u5fdc\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308a\u640d\u50b7\u304c\u751f\u3058\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u5185\u76ae\u7d30\u80de\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/endothelial-cell\">\u5185\u76ae\u7d30\u80de<\/a>\u00a0\u8840\u6db2\u8133\u95a2\u9580\u306e\u5b8c\u5168\u6027\u3092\u7834\u58ca\u3057\u3001\u8840\u7ba1\u6027\u6d6e\u816b\u3001\u51fa\u8840\u6027\u5909\u5316\u3001\u6b7b\u4ea1\u7387\u306e\u4e0a\u6607\u306b\u3064\u306a\u304c\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib183\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib183\"><span class=\"anchor-text\">[183]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib184\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib184\"><span class=\"anchor-text\">[184]<\/span><\/a>\u8133\u865a\u8840\u5f8c\u3001NLRP3\u306f\u30cb\u30e5\u30fc\u30ed\u30f3\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3001\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u3067\u30a2\u30c3\u30d7\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3055\u308c\u3001NLRP3\u907a\u4f1d\u5b50\u3092\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u3059\u308b\u3068\u3001\u8133\u6897\u585e\u306e\u4f53\u7a4d\u3092\u6e1b\u3089\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u4e2d\u5927\u8133\u52d5\u8108\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/middle-cerebral-artery\">\u4e2d\u5927\u8133\u52d5\u8108<\/a>\u00a0\u865a\u8840\u3068\u8840\u6db2\u8133\u95a2\u9580\u306e\u900f\u904e\u6027\u306e\u4f4e\u4e0b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib185\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib185\"><span class=\"anchor-text\">[185]<\/span><\/a>\u3002\u738b\u3089\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib186\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib186\"><span class=\"anchor-text\">[186]<\/span><\/a>\u00a0\u8133\u865a\u8840\u306f\u5fae\u5c0f\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u3092\u60aa\u5316\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u305f\u3002\u307e\u305f\u3001\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u30ac\u30f3\u30de\u30b3\u30a2\u30af\u30c1\u30d9\u30fc\u30bf\u30fc1\u03b1\uff08PGC-1\u03b1\uff09\u306e\u6d3b\u6027\u5316\u306b\u3088\u308a\u3001\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u304c\u5927\u5e45\u306b\u6e1b\u5c11\u3057\u3001ZO-1\u304a\u3088\u3073\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089 Occludin \u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/occludin\">\u30aa\u30af\u30eb\u30c7\u30a3\u30f3<\/a>\u00a0\u8840\u6db2\u8133\u95a2\u9580\u306e\u5b8c\u5168\u6027\u3092\u4fdd\u8b77\u3059\u308b\u305f\u3081\u306b\u3001\u8133\u5fae\u5c0f\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u5185\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3002\u3055\u3089\u306b\u3001\u8133\u5fae\u5c0f\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u306b\u3088\u308a\u3001IS\u5f8c\u306e\u51fa\u8840\u306e\u53ef\u80fd\u6027\u304c\u9ad8\u307e\u308a\u3001\u6b21\u306e\u3088\u3046\u306a\u91cd\u7be4\u306a\u5408\u4f75\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u5224\u660e\u3057\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u8133\u51fa\u8840\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebral-hemorrhage\">\u8133\u51fa\u8840<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib187\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib187\"><span class=\"anchor-text\">[187]<\/span><\/a>.<\/p>\n<div>\n<p id=\"p0135\">\u8133\u865a\u8840\u3068\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u95a2\u9023\u6027\u306f\u6b21\u306e\u3088\u3046\u306b\u8981\u7d04\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#fig0010\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"fig0010\"><span class=\"anchor-text\">\u56f32<\/span><\/a>.<\/p>\n<figure id=\"fig0010\" class=\"figure text-xs\"><img decoding=\"async\" src=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr2.jpg\" alt=\"Fig. 2\" height=\"362\" aria-describedby=\"cap0010\" \/><\/p>\n<ol class=\"u-margin-s-bottom\">\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"\u9ad8\u89e3\u50cf\u5ea6\u753b\u50cf\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9 (274KB)\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr2_lrg.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9:\u00a0<span class=\"download-link-title\">\u9ad8\u89e3\u50cf\u5ea6\u753b\u50cf\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9 (274KB)<\/span><\/span><\/a><\/li>\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"\u30d5\u30eb\u30b5\u30a4\u30ba\u306e\u753b\u50cf\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr2.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9:\u00a0<span class=\"download-link-title\">\u30d5\u30eb\u30b5\u30a4\u30ba\u306e\u753b\u50cf\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9<\/span><\/span><\/a><\/li>\n<\/ol>\n<p id=\"sp0010\"><span class=\"label\">\u56f32<\/span>\u3002 IS\u5f8c\u306e\u8840\u7ba1\u795e\u7d4c\u7d30\u80de\u306b\u304a\u3051\u308b\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u6982\u8981 [\u8840\u7ba1\u795e\u7d4c\u7d30\u80de\uff08\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3001\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u3001\u795e\u7d4c\u7d30\u80de\u304b\u3089\u306a\u308b\uff09\u306b\u304a\u3051\u308b\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u5206\u5b50\u6a5f\u69cb\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascular-endothelial-cell\">\u8840\u7ba1\u5185\u76ae\u7d30\u80de<\/a>\u3001\u5468\u76ae\u7d30\u80de\uff09IS\u5f8c\u3002 IRF:\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u8abf\u7bc0\u56e0\u5b50\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/interferon-regulatory-factor\">\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u8abf\u7bc0\u56e0\u5b50<\/a>; IFN:\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/interferon\">\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3<\/a>; CASP: \u30ab\u30b9\u30d1\u30fc\u30bc\u3002 GPX4: \u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u30da\u30eb\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc 4]\u3002<\/p>\n<\/figure>\n<\/div>\n<\/section>\n<\/section>\n<section id=\"sec0090\">\n<h2 id=\"sect0110\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">4. \u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u963b\u5bb3\u5264\u306b\u3088\u308bIS\u6cbb\u7642\u306e\u53ef\u80fd\u6027<\/h2>\n<p id=\"p0140\">\u8fd1\u5e74\u3001IS\u306b\u304a\u3051\u308b\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u963b\u5bb3\u5264\u306e\u7814\u7a76\u304c\u5927\u304d\u306a\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u307e\u3059\u3002\u30ea\u30e3\u30f3\u3089\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib188\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib188\"><span class=\"anchor-text\">[188]<\/span><\/a>\u00a0\u30ab\u30b9\u30d1\u30fc\u30bc1\u963b\u5bb3\u5264VX-765\u306f\u3001\u30ab\u30b9\u30d1\u30fc\u30bc1\u3001ASC\u3001GSDMD\u3001IL-1\u03b2\u3092\u6e1b\u5c11\u3055\u305b\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30bf\u30a4\u30c8\u30b8\u30e3\u30f3\u30af\u30b7\u30e7\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tight-junction-protein\">\u5bc6\u7740\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea<\/a>\u00a0\u305d\u3057\u3066\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a4\u30ca\u30fc\u30bc\u306e\u7d44\u7e54\u963b\u5bb3\u5264\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/metalloprotease-inhibitor\">\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a4\u30ca\u30fc\u30bc\u306e\u7d44\u7e54\u963b\u5bb3\u5264<\/a>\u3001\u8840\u6db2\u8133\u95a2\u9580\u306e\u5b8c\u5168\u6027\u3092\u4fdd\u8b77\u3059\u308b\u3002\u3055\u3089\u306b\u3001VX-765\u306f\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306eM1\u578b\u304b\u3089M2\u578b\u3078\u306e\u5909\u63db\u3092\u4fc3\u9032\u3057\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u304c\u5a92\u4ecb\u3059\u308b\u708e\u75c7\u53cd\u5fdc\u3092\u8efd\u6e1b\u3057\u3001\u795e\u7d4c\u4fdd\u8b77\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib189\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib189\"><span class=\"anchor-text\">[189]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib190\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib190\"><span class=\"anchor-text\">[190]<\/span><\/a>\u3002 MCC950 \u306f\u9078\u629e\u7684 NLRP3 \u963b\u5bb3\u5264\u3067\u3059\u3002\u7814\u7a76\u3067\u306f\u3001MCC950 \u304c\u865a\u8840\u5468\u7e01\u90e8\u306b\u304a\u3051\u308b NLRP3\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3001\u304a\u3088\u3073 IL-1\u03b2 \u306e\u767a\u73fe\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u30de\u30a6\u30b9\u306e\u5c40\u6240\u8133\u865a\u8840\u306b\u5bfe\u3057\u3066\u4fdd\u8b77\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3057\u305f\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib191\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib191\"><span class=\"anchor-text\">[191]<\/span><\/a>\u3002\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u3044\u304f\u3064\u304b\u306e\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30de\u30a4\u30af\u30ed RNA \u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microrna\">\u30de\u30a4\u30af\u30edRNA<\/a>\u00a0\u8133\u865a\u8840\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3092\u963b\u5bb3\u3057\u3001\u795e\u7d4c\u4fdd\u8b77\u306e\u5f79\u5272\u3092\u679c\u305f\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib192\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib192\"><span class=\"anchor-text\">[192]<\/span><\/a>LP17\u306f\u963b\u5bb3\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u9aa8\u9ac4\u7d30\u80de\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/myeloid-cell\">\u9aa8\u9ac4\u7d30\u80de<\/a>\u00a0\u53d7\u5bb9\u4f53-1\u3092\u30c8\u30ea\u30ac\u30fc\u3057\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u6291\u5236\u3057\u3001\u8133\u865a\u8840\u8a98\u767a\u6027\u306e\u795e\u7d4c\u640d\u50b7\u3092\u8efd\u6e1b\u3057\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib192\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib192\"><span class=\"anchor-text\">[192]<\/span><\/a>.\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30d2\u30b9\u30c1\u30b8\u30f3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/histidine\">\u30d2\u30b9\u30c1\u30b8\u30f3<\/a>\u00a0\u30a2\u30c7\u30cb\u30eb\u9178\u6d3b\u6027\u5316\u30bf\u30f3\u30d1\u30af\u8cea\u30ad\u30ca\u30fc\u30bc\/\u30b0\u30ea\u30b3\u30fc\u30b2\u30f3\u5408\u6210\u9175\u7d20\u30ad\u30ca\u30fc\u30bc-3\u03b2\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001NLRP3\u5a92\u4ecb\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3092\u963b\u5bb3\u3057\u3001\u6297CIRI\u795e\u7d4c\u4fdd\u8b77\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib193\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib193\"><span class=\"anchor-text\">[193]<\/span><\/a>\u3002\u4f4e\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u53d7\u5bb9\u4f53\u306f\u3001CIRI\u5f8c\u306eNLRP3\u5a92\u4ecb\u795e\u7d4c\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u963b\u5bb3\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib194\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib194\"><span class=\"anchor-text\">[194]<\/span><\/a>\u8102\u8cea\u30a2\u30eb\u30b3\u30fc\u30eb\u5a92\u4ecb\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u03b1-\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u30aa\u30ad\u30b5\u30ed\u9162\u9178\u30c8\u30e9\u30f3\u30b9\u30a2\u30df\u30ca\u30fc\u30bc1\u8ef8\u306f\u3001IS\u5f8c\u306e\u5185\u76ae\u7d30\u80de\u306e\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3092\u963b\u5bb3\u3057\u3001\u865a\u8840\u6027\u8133\u969c\u5bb3\u3092\u6539\u5584\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib195\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib195\"><span class=\"anchor-text\">[195]<\/span><\/a>CHRFAM7A\u306e\u904e\u5270\u767a\u73fe\u306fNLRP3\/\u30ab\u30b9\u30d1\u30fc\u30bc-1\u7d4c\u8def\u4f9d\u5b58\u6027\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3092\u963b\u5bb3\u3057\u3001CIRI\u3092\u6e1b\u5f31\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib196\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib196\"><span class=\"anchor-text\">[196]<\/span><\/a>TP53\u8a98\u5c0e\u89e3\u7cd6\u304a\u3088\u3073\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u8abf\u7bc0\u56e0\u5b50\u306f\u8133\u865a\u8840\u8a98\u767a\u6027\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u304a\u3088\u3073\u865a\u8840\u6027\u8133\u969c\u5bb3\u3092\u8efd\u6e1b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib197\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib197\"><span class=\"anchor-text\">[197]<\/span><\/a>\u3002 \u52a0\u3048\u3066\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/exosome\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0<\/a>\u00a0\u4f4e\u9178\u7d20\u9aa8\u9ac4\u7531\u6765\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u9593\u8449\u7cfb\u5e79\u7d30\u80de\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mesenchymal-stem-cell\">\u9593\u8449\u7cfb\u5e79\u7d30\u80de<\/a>\u00a0\u30df\u30af\u30ed\u30b0\u30ea\u30a2M1\/M2\u8868\u73fe\u578b\u3092\u8abf\u7bc0\u3057\u3066CIRI\u8a98\u767a\u6027\u795e\u7d4c\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3092\u8efd\u6e1b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib198\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib198\"><span class=\"anchor-text\">[198]<\/span><\/a>\u4f4e\u9178\u7d20\u524d\u51e6\u7406\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u55c5\u7c98\u819c\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/olfactory-mucosa\">\u55c5\u7c98\u819c<\/a>\u00a0\u9593\u8449\u7cfb\u5e79\u7d30\u80de\u306f\u3001\u4f4e\u9178\u7d20\u8a98\u5c0e\u56e0\u5b50-1\u03b1\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u8133\u865a\u8840\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3068\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u963b\u5bb3\u3057\u3001\u305d\u308c\u306b\u3088\u3063\u3066CIRI\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib199\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib199\"><span class=\"anchor-text\">[199]<\/span><\/a>.<\/p>\n<p id=\"p0145\">GSDMD \u306f\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306e\u5b9f\u884c\u8005\u3068\u3057\u3066\u3001IS \u306e\u6cbb\u7642\u306b\u7406\u60f3\u7684\u306a\u5206\u5b50\u30bf\u30fc\u30b2\u30c3\u30c8\u3067\u3059\u3002\u3057\u304b\u3057\u3001GSDMD \u963b\u5bb3\u5264\u306b\u95a2\u3059\u308b\u73fe\u5728\u306e\u7814\u7a76\u306f\u307e\u3060\u521d\u671f\u6bb5\u968e\u306b\u3042\u308a\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u6cbb\u7642\u306b\u304a\u3051\u308b GSDMD \u963b\u5bb3\u5264\u306e\u6709\u52b9\u6027\u3092\u793a\u3059\u8a3c\u62e0\u306f\u4e0d\u8db3\u3057\u3066\u3044\u307e\u3059\u3002\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u4e00\u90e8\u306e\u5929\u7136\u690d\u7269\u6210\u5206\u304c\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3067 IS \u3092\u6cbb\u7642\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<\/section>\n<section id=\"sec0095\">\n<h2 id=\"sect0115\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">5. \u5929\u7136\u7269\u306f\u65b0\u898f\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u963b\u5bb3\u5264\u3068\u3057\u3066\u3001IS\u306e\u6cbb\u7642\u85ac\u5019\u88dc\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/h2>\n<p id=\"p0150\">\u5929\u7136\u7269\u306f\u3001\u591a\u6210\u5206\u3001\u591a\u6a19\u7684\u3001\u591a\u7d4c\u8def\u3001\u4f4e\u6bd2\u6027\u306a\u3069\u306e\u5229\u70b9\u306b\u3088\u308a\u3001\u8133\u6897\u585e\/\u8133\u865a\u8840\u518d\u704c\u6d41\u306e\u4e88\u9632\u3068\u6cbb\u7642\u306b\u5927\u304d\u306a\u5229\u70b9\u304c\u3042\u308a\u3001\u5fdc\u7528\u306e\u898b\u901a\u3057\u3082\u826f\u597d\u3067\u3059\u3002\u73fe\u5728\u3001\u8133\u6897\u585e\/\u8133\u865a\u8840\u518d\u704c\u6d41\u306e\u4e88\u9632\u3068\u6cbb\u7642\u306b\u304a\u3051\u308b\u5929\u7136\u7269\u306e\u7814\u7a76\u306f\u5f90\u3005\u306b\u5897\u52a0\u3057\u3066\u304a\u308a\u3001\u3055\u307e\u3056\u307e\u306a\u4fdd\u8b77\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u3067\u306f\u3001\u5929\u7136\u7269\u3001\u52d5\u7269\u307e\u305f\u306f\u7d30\u80de\u30e2\u30c7\u30eb\u3001\u6295\u4e0e\u65b9\u6cd5\u3001\u6295\u4e0e\u91cf\u3001\u6cbb\u7642\u6642\u9593\u3001\u52b9\u679c\u3001\u6cbb\u7642\u30e1\u30ab\u30cb\u30ba\u30e0\uff08\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\uff09\u3092\u307e\u3068\u3081\u3001IS\/CIRI\u306e\u4e88\u9632\u3068\u6cbb\u7642\u306e\u305f\u3081\u306e\u5b89\u5168\u3067\u52b9\u679c\u7684\u3067\u3001\u6bd2\u6027\u304c\u4f4e\u304f\u3001\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3092\u5236\u5fa1\u3059\u308b\u5929\u7136\u690d\u7269\u6210\u5206\u306e\u8fc5\u901f\u306a\u63a2\u7d22\u306b\u5bfe\u3059\u308b\u7406\u8ad6\u7684\u30b5\u30dd\u30fc\u30c8\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002<\/p>\n<section id=\"sec0100\">\n<h3 id=\"sect0120\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">5.1.\u5929\u7136\u690d\u7269\u6210\u5206<\/h3>\n<div>\n<p id=\"p0155\">\u5929\u7136\u690d\u7269\u6210\u5206\u306e\u4e3b\u306a\u69cb\u9020\u306f\u6b21\u306e\u3068\u304a\u308a\u3067\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#fig0015\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"fig0015\"><span class=\"anchor-text\">\u56f33<\/span><\/a>.<\/p>\n<figure id=\"fig0015\" class=\"figure text-xs\"><img decoding=\"async\" src=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr3.jpg\" alt=\"Fig. 3\" height=\"397\" aria-describedby=\"cap0015\" \/><\/p>\n<ol class=\"u-margin-s-bottom\">\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"\u9ad8\u89e3\u50cf\u5ea6\u753b\u50cf\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9 (208KB)\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr3_lrg.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9:\u00a0<span class=\"download-link-title\">\u9ad8\u89e3\u50cf\u5ea6\u753b\u50cf\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9 (208KB)<\/span><\/span><\/a><\/li>\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"\u30d5\u30eb\u30b5\u30a4\u30ba\u306e\u753b\u50cf\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr3.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9:\u00a0<span class=\"download-link-title\">\u30d5\u30eb\u30b5\u30a4\u30ba\u306e\u753b\u50cf\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9<\/span><\/span><\/a><\/li>\n<\/ol>\n<p id=\"sp0015\"><span class=\"label\">\u56f33<\/span>\u5929\u7136\u690d\u7269\u6210\u5206\u306e\u4e3b\u306a\u69cb\u9020\u3002<\/p>\n<\/figure>\n<\/div>\n<section id=\"sec0105\">\n<h4 id=\"sect0125\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.1. \u30ac\u30b9\u30c8\u30ed\u30b8\u30f3\uff08GAS\uff09<\/h4>\n<p id=\"p0160\">GAS\u306f\u30cf\u30fc\u30d6\u304b\u3089\u62bd\u51fa\u3055\u308c\u305f\u591a\u6a5f\u80fd\u5316\u5408\u7269\u3067\u3059\u3002\u00a0<em><a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089 Gastrodia elata \u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/gastrodia-elata\">\u30ac\u30b9\u30c8\u30ed\u30c7\u30a3\u30a2\u30fb\u30a8\u30e9\u30bf<\/a><\/em>\u3001\u69d8\u3005\u306a\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u85ac\u7406\u5b66\u7684\u6d3b\u52d5\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/pharmacological-activity\">\u85ac\u7406\u6d3b\u6027<\/a>\u3001\u6297\u9178\u5316\u4f5c\u7528\u3084\u6297\u708e\u75c7\u4f5c\u7528\u306a\u3069\u3002\u3055\u3089\u306b\u3001GAS \u306f\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-3 \u5207\u65ad\u3001IL-18\u3001IL-1\u03b2 \u306a\u3069\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u4fc3\u9032\u56e0\u5b50\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u8133\u865a\u8840\u518d\u704c\u6d41\u306e\u75c7\u72b6\u3092\u5927\u5e45\u306b\u8efd\u6e1b\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3044\u304f\u3064\u304b\u306e\u7814\u7a76\u3067\u306f\u3001GAS \u304c\u8133\u865a\u8840\u640d\u50b7\u3092\u6539\u5584\u3057\u3001\u8133\u865a\u8840\u30ec\u30d9\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u6d3b\u6027\u9178\u7d20\u7a2e\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/reactive-oxygen-species\">\u6d3b\u6027\u9178\u7d20\u7a2e<\/a>\u00a0\u305d\u3057\u3066\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammatory-cytokine\">\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3<\/a>\u00a0\u30de\u30a6\u30b9\u3067\u306f\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib200\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib200\"><span class=\"anchor-text\">[200]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib201\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib201\"><span class=\"anchor-text\">[201]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib202\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib202\"><span class=\"anchor-text\">[202]<\/span><\/a>\u3002\u30eb\u30fc\u3089\u3002 GAS\u306f\u3001NLRP3\/\u30ab\u30b9\u30d1\u30fc\u30bc-1\u8ef8\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u5fc3\u81d3\u5fae\u5c0f\u8840\u7ba1\u865a\u8840\u518d\u704c\u6d41\u50b7\u5bb3\u306b\u95a2\u9023\u3059\u308b\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u6539\u5584\u3067\u304d\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u305f\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib203\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib203\"><span class=\"anchor-text\">[203]<\/span><\/a>\u3002 GAS \u306f\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u795e\u7d4c\u6a5f\u80fd\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nervous-system-physiology\">\u795e\u7d4c\u6a5f\u80fd<\/a>\u00a0\u30b9\u30b3\u30a2\u3092\u4ed8\u3051\u3066\u30b5\u30a4\u30ba\u3092\u7e2e\u5c0f\u3059\u308b\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u8133\u6897\u585e\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-infarction\">\u8133\u6897\u585e<\/a>\u4e00\u65b9\u3001GAS\u306fNLRP3\u3001\u708e\u75c7\u6027\u56e0\u5b50\uff08IL-1\u03b2\u3001IL-18\uff09\u304a\u3088\u3073\u5207\u65ad\u3055\u308c\u305f\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3092\u30c0\u30a6\u30f3\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3059\u308b\u3053\u3068\u3067\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3092\u963b\u5bb3\u3057\u305f\u3002\u3055\u3089\u306b\u3001GAS\u306flncRNA NEAT1\/miR-22\u20133p\u8ef8\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3067\u865a\u8840\u518d\u704c\u6d41\u8a98\u767a\u6027\u795e\u7d4c\u7d30\u80de\u708e\u75c7\u3092\u8efd\u6e1b\u3057\u305f\u3002GAS\u306flncRNA NEAT1\/miR-22\u20133p\u8ef8\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3067\u8133\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u3092\u5927\u5e45\u306b\u8efd\u6e1b\u3057\u305f\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib204\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib204\"><span class=\"anchor-text\">[204]<\/span><\/a>\u3057\u305f\u304c\u3063\u3066\u3001GAS\u306f\u6f5c\u5728\u7684\u306a\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u85ac\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chemotherapeutic-agent\">\u85ac<\/a>\u00a0CIRI\u306e\u6cbb\u7642\u306b\u3002<\/p>\n<\/section>\n<section id=\"sec0110\">\n<h4 id=\"sect0130\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.2. \u30bf\u30f3\u30b7\u30ce\u30f3IIA<\/h4>\n<p id=\"p0165\"><a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30bf\u30f3\u30b7\u30ce\u30f3IIA\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tanshinone-iia\">\u30bf\u30f3\u30b7\u30ce\u30f3IIA<\/a>\u00a0\u306e\u4e3b\u306a\u6709\u52b9\u6210\u5206\u3067\u3042\u308b\u00a0<em><a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089 Salvia miltiorrhiza \u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/salvia-miltiorrhiza\">\u30b5\u30eb\u30d3\u30a2\u30fb\u30df\u30eb\u30c6\u30a3\u30aa\u30ea\u30b6<\/a><\/em>\u5fc3\u81d3\u8840\u7ba1\u75be\u60a3\u3084\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u8133\u8840\u7ba1\u75be\u60a3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebrovascular-disease\">\u8133\u8840\u7ba1\u75be\u60a3<\/a>\u00a0\u6297\u9178\u5316\u4f5c\u7528\u3068\u8840\u884c\u6539\u5584\u4f5c\u7528\u304c\u3042\u308b\u305f\u3081\u3002Cai et al.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib205\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib205\"><span class=\"anchor-text\">[205]<\/span><\/a>\u00a0\u30bf\u30f3\u30b7\u30ce\u30f3IIA\u306fNLRP3\u708e\u75c7\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306b\u304a\u3051\u308bIL-1\u03b2\u304a\u3088\u3073IL-18\u306e\u767a\u73fe\u3092\u52b9\u679c\u7684\u306b\u6e1b\u5c11\u3055\u305b\u3001\u305d\u306e\u52b9\u679c\u306f\u7528\u91cf\u4f9d\u5b58\u7684\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u30bf\u30f3\u30b7\u30ce\u30f3IIA\u304cNLRP3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u3092\u963b\u5bb3\u3057\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u8133\u5352\u4e2d\u5f8c\u306eBV-2\u7d30\u80de\u306b\u5bfe\u3059\u308b\u9178\u7d20-\u30b0\u30eb\u30b3\u30fc\u30b9\u6b20\u4e4f\/\u518d\u704c\u6d41\u306e\u640d\u50b7\u3092\u8efd\u6e1b\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/section>\n<section id=\"sec0115\">\n<h4 id=\"sect0135\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.3.\u30ec\u30aa\u30cc\u30ea\u30f3<\/h4>\n<p id=\"p0170\"><a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30ec\u30aa\u30cc\u30ea\u30f3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/leonurine\">\u30ec\u30aa\u30cc\u30ea\u30f3<\/a>\u00a0\u3067\u00a0<em><a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30ec\u30aa\u30cc\u30ea\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/leonurus\">\u30ec\u30aa\u30cc\u30ea<\/a><\/em><em>\u00a0\u30cf\u30fc\u30d6<\/em>\u00a0\u6162\u6027\u8133\u865a\u8840\u30e9\u30c3\u30c8\u306e\u5b66\u7fd2\u80fd\u529b\u3068\u8a18\u61b6\u80fd\u529b\u3092\u6539\u5584\u3057\u3001NLRP3\u306e\u767a\u73fe\u3092\u6e1b\u5c11\u3055\u305b\u307e\u3057\u305f\u3002\u795e\u7d4c\u3092\u4fdd\u8b77\u3059\u308b\u3068\u3044\u3046\u76ee\u7684\u306f\u3001\u6297\u708e\u75c7\u4f5c\u7528\u306b\u3088\u3063\u3066\u9054\u6210\u3055\u308c\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u63a8\u6e2c\u3055\u308c\u3066\u3044\u307e\u3059\u3002 NLRP3 \u306e\u6d3b\u6027\u5316\u306b\u3088\u308a\u3001\u30ab\u30b9\u30d1\u30fc\u30bc 1 \u524d\u99c6\u4f53\u306e\u30ab\u30b9\u30d1\u30fc\u30bc 1 \u3078\u306e\u5909\u63db\u304c\u4fc3\u9032\u3055\u308c\u3001IL-1\u03b2 \u304a\u3088\u3073 IL-18 \u306e\u7523\u751f\u304c\u4fc3\u9032\u3055\u308c\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u4e00\u9023\u306e\u708e\u75c7\u53cd\u5fdc\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3057\u305f\u3002\u30ec\u30aa\u30cc\u30ea\u30f3\u306f\u8133\u7d44\u7e54\u306e\u708e\u75c7\u53cd\u5fdc\u3092\u8efd\u6e1b\u3057\u3001\u7d30\u80de\u306e\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u795e\u7d4c\u5b66\u7684\u6b20\u640d\u30b9\u30b3\u30a2\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u826f\u597d\u306a\u795e\u7d4c\u4fdd\u8b77\u52b9\u679c\u3092\u6709\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib206\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib206\"><span class=\"anchor-text\">[206]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0120\">\n<h4 id=\"sect0140\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.4.\u30da\u30aa\u30cb\u30d5\u30ed\u30ea\u30f3<\/h4>\n<p id=\"p0175\"><a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30da\u30aa\u30cb\u30d5\u30ed\u30ea\u30f3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/paeoniflorin\">\u30da\u30aa\u30cb\u30d5\u30ed\u30ea\u30f3<\/a>\u00a0\uff5e\u306e\u4e3b\u6210\u5206\u306b\u7531\u6765\u3059\u308b\u00a0<em><a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30b7\u30e3\u30af\u30e4\u30af\u306e\u8a73\u7d30\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/radix-paeoniae-rubra\">\u30b7\u30e3\u30af\u30e4\u30af radix redx<\/a><\/em>\u30da\u30aa\u30cb\u30d5\u30ed\u30ea\u30f3\u306f\u3001\u7dcf\u30b0\u30eb\u30b3\u30b7\u30c9\u306e\u4e3b\u306a\u6709\u52b9\u6210\u5206\u3067\u3042\u308b\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u7261\u4e39\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/paeonia\">\u7261\u4e39<\/a>\u00a0\uff08TGP\uff09\u306f\u6297\u708e\u75c7\u4f5c\u7528\u3068\u514d\u75ab\u8abf\u7bc0\u4f5c\u7528\u306b\u3082\u512a\u308c\u3066\u3044\u307e\u3059\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib207\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib207\"><span class=\"anchor-text\">[207]<\/span><\/a>TGP\u3068\u30da\u30aa\u30cb\u30d5\u30ed\u30ea\u30f3\u306b\u306f\u3001\u6b21\u306e\u3088\u3046\u306a\u69d8\u3005\u306a\u85ac\u7406\u4f5c\u7528\u3082\u3042\u308a\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u93ae\u75d9\u85ac\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antispasmodic\">\u93ae\u75d9\u85ac<\/a>,\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u93ae\u75db\u5264\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/anodyne\">\u93ae\u75db\u5264<\/a>\u3001 \u305d\u3057\u3066\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u8840\u7ba1\u62e1\u5f35\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vasodilatation\">\u8840\u7ba1\u62e1\u5f35<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib208\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib208\"><span class=\"anchor-text\">[208]<\/span><\/a>\u30ba\u30ea\u30d5\u30a3\u30e4\u30fb\u30a8\u30b1\u30e0\u3089\u306f\u3001\u6025\u6027\u8133\u865a\u8840\u518d\u704c\u6d41\u5f8c\u3001\u8133\u5185\u306e\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3068\u795e\u7d4c\u7d30\u80de\u306e\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306e\u6d3b\u6027\u5316\u304c\u660e\u3089\u304b\u3067\u3042\u308a\u3001NLRP3\u306e\u6d3b\u6027\u5316\u304c\u5897\u52a0\u3057\u3001\u30ab\u30b9\u30d1\u30fc\u30bc1\u3068IL-1\u03b2\u304c\u30a2\u30c3\u30d7\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u305f\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib209\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib209\"><span class=\"anchor-text\">[209]<\/span><\/a>\u3002\u30da\u30aa\u30cb\u30d5\u30ed\u30ea\u30f3\u306f\u795e\u7d4c\u6a5f\u80fd\u30b9\u30b3\u30a2\u3092\u5927\u5e45\u306b\u4f4e\u4e0b\u3055\u305b\u3001\u5927\u5e45\u306b\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u8133\u6897\u585e\u306e\u30b5\u30a4\u30ba\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-infarction-size\">\u8133\u6897\u585e\u306e\u5927\u304d\u3055<\/a>\u3001Iba1\u767a\u73fe\u304c\u5927\u5e45\u306b\u4e0b\u65b9\u5236\u5fa1\u3055\u308c\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u72b6\u614b\u304c\u5927\u5e45\u306b\u6539\u5584\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001NLRP3\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3001\u304a\u3088\u3073IL-1\u03b2\u306e\u767a\u73fe\u306f\u3001\u30da\u30aa\u30cb\u30d5\u30ed\u30ea\u30f3\u4ecb\u5165\u5f8c\u306b\u6709\u610f\u306b\u6e1b\u5c11\u3057\u305f\u3002\u30da\u30aa\u30cb\u30d5\u30ed\u30ea\u30f3\u306f\u3001NLRP3 \u3068 Caspase-1 \u306e\u6d3b\u6027\u5316\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u6d3b\u6027\u5316\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u963b\u5bb3\u3057\u3001ACI \u3092\u4ecb\u3057\u305f\u795e\u7d4c\u640d\u50b7\u3092\u6539\u5584\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib209\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib209\"><span class=\"anchor-text\">[209]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0125\">\n<h4 id=\"sect0145\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.5.\u30d6\u30c1\u30eb\u30d5\u30bf\u30ea\u30c9<\/h4>\n<p id=\"p0180\"><span class=\"small-caps\">\u3089<\/span>\u30d6\u30c1\u30eb\u30d5\u30bf\u30ea\u30c9\u306f\u6700\u521d\u306b\u30af\u30ec\u30bd\u30f3\u306e\u7a2e\u5b50\u304b\u3089\u5358\u96e2\u3055\u308c\u3001\u5f8c\u306b\u4eba\u5de5\u7684\u306b\u5408\u6210\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30d6\u30c1\u30eb\u30d5\u30bf\u30ea\u30c9\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/butylphthalide\">\u30d6\u30c1\u30eb\u30d5\u30bf\u30ea\u30c9<\/a>\u00a0\u30e6\u30cb\u30fc\u30af\u306a\u4e8c\u91cd\u306e\u5f79\u5272\u3092\u6301\u3061\u3001\u518d\u69cb\u7bc9\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u5fae\u5c0f\u5faa\u74b0\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microcirculation\">\u5fae\u5c0f\u5faa\u74b0<\/a>\u00a0\u865a\u8840\u518d\u704c\u6d41\u3092\u5897\u52a0\u3055\u305b\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u8840\u7ba1\u69cb\u9020\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/blood-vessel\">\u8840\u7ba1\u69cb\u9020<\/a>\u3001\u8840\u7ba1\u306e\u76f4\u5f84\u3092\u56de\u5fa9\u3057\u3001\u865a\u8840\u9818\u57df\u3068\u5468\u56f2\u306e\u8840\u6d41\u6570\u3092\u5897\u52a0\u3055\u305b\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u5fae\u5c0f\u8840\u7ba1\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microvessel\">\u5fae\u5c0f\u8840\u7ba1<\/a>\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u4fdd\u8b77\u3057\u3001\u7d30\u80de\u6b7b\u3092\u6e1b\u3089\u3059\u3053\u3068\u3067\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u69cb\u9020\u306e\u5b8c\u5168\u6027\u3092\u4fdd\u8b77\u3057\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u8907\u5408\u9175\u7d20IV\u306e\u6d3b\u6027\u3092\u6539\u5584\u3057\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2ATP\u9175\u7d20\u306e\u6d3b\u6027\u3092\u6539\u5584\u3057\u3001\u5b89\u5b9a\u6027\u3092\u7dad\u6301\u3057\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u819c\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitochondrial-membrane\">\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u819c<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib210\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib210\"><span class=\"anchor-text\">[210]<\/span><\/a>\u6700\u65b0\u306e\u7814\u7a76\u3067\u306f\u3001\u30d6\u30c1\u30eb\u30d5\u30bf\u30ea\u30c9\u304cNLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u4ecb\u3057\u3066\u7528\u91cf\u4f9d\u5b58\u7684\u306bCIRI\u30e9\u30c3\u30c8\u306e\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/section>\n<section id=\"sec0130\">\n<h4 id=\"sect0150\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.6. \u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/h4>\n<p id=\"p0185\"><a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/breviscapine\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/a>\u00a0\u304b\u3089\u62bd\u51fa\u3055\u308c\u308b\u00a0<em><a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089 Erigeron breviscapus \u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/erigeron-breviscapus\">\u30a8\u30ea\u30b2\u30ed\u30f3\u30fb\u30d6\u30ec\u30d3\u30b9\u30ab\u30d7\u30b9<\/a><\/em>\u00a0\uff08\u30f4\u30a1\u30f3\u30c8\uff09\u30cf\u30f3\u30c9\u3002 -\u30de\u30c3\u30c4\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30b9\u30af\u30c6\u30e9\u30ea\u30f3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/scutellarin\">\u30b9\u30af\u30c6\u30e9\u30ea\u30f3<\/a>\u00a0\u30b9\u30af\u30c6\u30e9\u30ea\u30f3\u3092\u4e3b\u6210\u5206\u3068\u3057\u3001\u5c11\u91cf\u306e\u30b9\u30af\u30c6\u30e9\u30ea\u30f3\u3092\u914d\u5408\u3002\u8133\u8840\u7ba1\u3092\u62e1\u5f35\u3057\u3001\u8133\u8840\u7ba1\u62b5\u6297\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u8133\u8840\u6d41\u3092\u5897\u52a0\u3055\u305b\u3001\u5fae\u5c0f\u5faa\u74b0\u3092\u6539\u5584\u3057\u3001\u6297\u9178\u5316\u4f5c\u7528\u3092\u6709\u3059\u308b\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u8840\u5c0f\u677f\u51dd\u96c6\u306e\u8a73\u7d30\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/thrombocyte-aggregation\">\u8840\u5c0f\u677f\u51dd\u96c6<\/a>\u3002\u6700\u65b0\u306e\u7814\u7a76\u3067\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304cNLRP3\u708e\u75c7\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u6709\u610f\u306b\u963b\u5bb3\u3057\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u6d77\u99ac\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hippocampus\">\u6d77\u99ac<\/a>\u00a0CCI\u30e9\u30c3\u30c8\u306e\u30ab\u30b9\u30d1\u30fc\u30bc1\u3001IL-6\u3001IL-1\u03b2\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u3092\u6291\u5236\u3057\u3001\u30ab\u30b9\u30d1\u30fc\u30bc3\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6d3b\u6027\u5316\u3092\u963b\u5bb3\u3057\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroapoptosis\">\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9<\/a>\u3002\u3053\u308c\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c CCI \u30e9\u30c3\u30c8\u306e\u8a8d\u77e5\u6a5f\u80fd\u3092\u5927\u5e45\u306b\u6539\u5584\u3057\u3001\u865a\u8840\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u75c5\u7406\u5b66\u7684\u640d\u50b7\u3092\u8efd\u6e1b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u8133\u7d44\u7e54\u306b\u304a\u3051\u308b NLRP3 \u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u6d3b\u6027\u5316\u3068\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u306e\u963b\u5bb3\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib211\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib211\"><span class=\"anchor-text\">[211]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0135\">\n<h4 id=\"sect0155\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.7. \u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb<\/h4>\n<p id=\"p0190\"><a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/resveratrol\">\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb<\/a>\u00a0\u975e\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u3067\u3042\u308b\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u5316\u5408\u7269\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/polyphenol-derivative\">\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u5316\u5408\u7269<\/a>\u3002\u305d\u308c\u306f\u6700\u521d\u306b\u6839\u304b\u3089\u5206\u96e2\u3055\u308c\u307e\u3057\u305f\u3002\u00a0<em><a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089Veratrum\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/veratrum\">\u30d9\u30e9\u30c8\u30eb\u30e0<\/a><\/em><em>\u00a0\u30b0\u30e9\u30f3\u30c7\u30a3\u30d5\u30ed\u30e9\u30e0<\/em>\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u306f700\u7a2e\u985e\u4ee5\u4e0a\u306e\u690d\u7269\u306b\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u306f\u8133\u6897\u585e\u306b\u304a\u3051\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u8abf\u7bc0\u3001\u708e\u75c7\u306e\u6291\u5236\u3001\u8133\u6a5f\u80fd\u306e\u6539\u5584\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u795e\u7d4c\u4fdd\u8b77\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroprotection\">\u795e\u7d4c\u4fdd\u8b77<\/a>\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u306f\u3001\u4e3b\u306b\u30df\u30af\u30ed\u30b0\u30ea\u30a2NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3001ZO-1\u306e\u8abf\u7bc0\u3092\u4ecb\u3057\u3066\u865a\u8840\u518d\u704c\u6d41\u8133\u7d44\u7e54\u306e\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3092\u5236\u5fa1\u3057\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib212\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib212\"><span class=\"anchor-text\">[212]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0140\">\n<h4 id=\"sect0160\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.8. \u30b5\u30eb\u30d3\u30a2\u30ce\u30fc\u30eb\u9178\uff08SAFI\uff09<\/h4>\n<p id=\"p0195\">\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001SAFI \u304c\u795e\u7d4c\u5b66\u7684\u6b20\u640d\u30b9\u30b3\u30a2\u3092\u5927\u5e45\u306b\u5897\u52a0\u3055\u305b\u3001\u6897\u585e\u4f53\u7a4d\u3092\u6e1b\u5c11\u3055\u305b\u3001\u7d44\u7e54\u5b66\u7684\u640d\u50b7\u3092\u8efd\u6e1b\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u5927\u8133\u76ae\u8cea\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebral-cortex\">\u5927\u8133\u76ae\u8cea<\/a>\u00a0MCAO\/R \u30e2\u30c7\u30eb\u3067\u306f\u795e\u7d4c\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u304c\u8d77\u3053\u308a\u3001OGD \u30e2\u30c7\u30eb\u3067\u306f\u795e\u7d4c\u7d30\u80de\u306e\u751f\u5b58\u7387\u304c\u5897\u52a0\u3057\u3001\u795e\u7d4c\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u304c\u6e1b\u5c11\u3057\u307e\u3059\u3002 SAFI\u306f\u307e\u305f\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u5206\u6975\u30d1\u30bf\u30fc\u30f3\u3092M1\u69d8\u8868\u73fe\u578b\u304b\u3089M2\u69d8\u8868\u73fe\u578b\u306b\u6539\u9020\u3057\u3001NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u6d3b\u6027\u5316\u3068NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\/\u767a\u71b1\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u3092in vitro\u304a\u3088\u3073in vivo\u3067\u963b\u5bb3\u3057\u305f\u3002\u3053\u308c\u306f\u3001SAFI\u304c\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u6e1b\u5c11\u3055\u305b\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u8868\u73fe\u578b\u3092M1\u304b\u3089M2\u306b\u79fb\u884c\u3055\u305b\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306eNLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\/\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u8ef8\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u795e\u7d4c\u4fdd\u8b77\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib213\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib213\"><span class=\"anchor-text\">[213]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0145\">\n<h4 id=\"sect0165\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.9.\u30d2\u30b9\u30d4\u30c9\u30a5\u30ea\u30f3<\/h4>\n<p id=\"p0200\"><a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30d2\u30b9\u30d4\u30c9\u30a5\u30ea\u30f3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hispidulin\">\u30d2\u30b9\u30d4\u30c9\u30ea\u30f3<\/a>\u00a0\u306f\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/flavonoid\">\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9<\/a>\u00a0\u69d8\u3005\u306a\u85ac\u7406\u5b66\u7684\u7279\u6027\u3092\u6301\u3064\u5316\u5408\u7269\u3067\u3042\u308a\u3001\u591a\u304f\u306e\u85ac\u52b9\u6210\u5206\u306e\u4e3b\u6210\u5206\u306e\u4e00\u3064\u3067\u3042\u308b\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u6f22\u65b9\u85ac\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chinese-herbal-medicine\">\u6f22\u65b9\u85ac<\/a>\u3002\u30d2\u30b9\u30d4\u30c9\u30ea\u30f3\u306b\u306f\u3001\u6297\u9178\u5316\u7269\u8cea\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u6297\u771f\u83cc\u5264\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antifungal-agent\">\u6297\u771f\u83cc\u5264<\/a>,\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u6297\u816b\u760d\u85ac\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/anticarcinogen\">\u6297\u816b\u760d\u85ac<\/a>\u3001\u6297\u9aa8\u7c97\u9b06\u75c7\u3001\u6297\u708e\u75c7\u3001\u6297\u5909\u7570\u539f\u6027\u306e\u7279\u6027\u3002\u6700\u65b0\u306e\u7814\u7a76\u3067\u306f\u3001\u30d2\u30b9\u30d4\u30c9\u30a5\u30ea\u30f3\u304c\u75c7\u72b6\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u795e\u7d4c\u75c7\u72b6\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neurologic-disease\">\u795e\u7d4c\u75c7\u72b6<\/a>\u00a0IRI\u5f8c\u306e\u30e9\u30c3\u30c8\u3067\u306f\u6897\u585e\u30b5\u30a4\u30ba\u304c\u6e1b\u5c11\u3057\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u8133\u6d6e\u816b\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-edema\">\u8133\u6d6e\u816b<\/a>\u30d2\u30b9\u30d4\u30c9\u30ea\u30f3\u306f\u3001AMPK\/GSK3\u03b2\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001NLRP3\u3092\u4ecb\u3057\u305f\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u3001\u751f\u4f53\u5185\u304a\u3088\u3073\u8a66\u9a13\u7ba1\u5185\u3067\u795e\u7d4c\u4fdd\u8b77\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib214\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib214\"><span class=\"anchor-text\">[214]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0150\">\n<h4 id=\"sect0170\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.10.\u30a2\u30b9\u30c8\u30e9\u30ac\u30ed\u30b7\u30c9 IV<\/h4>\n<p id=\"p0205\"><em><a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u9ec4\u8006\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/astragalus-root\">\u9ec4\u8006<\/a><\/em>\u00a0\u6b20\u4e4f\u3092\u88dc\u3044\u3001\u813e\u81d3\u3068\u80c3\u3092\u5f37\u5316\u3057\u3001\u8840\u6db2\u5faa\u74b0\u3092\u4fc3\u9032\u3057\u3001\u8840\u6db2\u5faa\u74b0\u3092\u4fc3\u9032\u3057\u3001\u75c7\u72b6\u3092\u6cbb\u7642\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u6c17\u865a\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/qi-deficiency\">\u6c17\u306e\u6b20\u4e4f<\/a>\u00a0\u8840\u6db2\u4e0d\u8db3\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib215\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib215\"><span class=\"anchor-text\">[215]<\/span><\/a>.\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30a2\u30b9\u30c8\u30e9\u30ac\u30ed\u30b7\u30c9IV\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/astragaloside-iv\">\u30a2\u30b9\u30c8\u30e9\u30ac\u30ed\u30b7\u30c9IV<\/a>\u00a0\u306e\u4e3b\u306a\u6709\u52b9\u6210\u5206\u306e\u4e00\u3064\u3067\u3042\u308b\u00a0<em>\u9ec4\u8006<\/em>\u00a0\u305d\u3057\u3066\u305d\u306e\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30e2\u30ce\u30de\u30fc\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/monomer\">\u30e2\u30ce\u30de\u30fc<\/a>\u00a0\u306e\u6210\u5206\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089 Astragalus \u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/astragalus\">\u30a2\u30b9\u30c8\u30e9\u30ac\u30eb\u30b9<\/a>\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30b5\u30dd\u30cb\u30f3\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/saponin\">\u30b5\u30dd\u30cb\u30f3<\/a>\u3002\u30ec\u30f3\u30b2\u306e\u54c1\u8cea\u3092\u691c\u67fb\u3059\u308b\u305f\u3081\u306e\u57fa\u6e96\u3068\u3057\u3066\u3088\u304f\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib216\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib216\"><span class=\"anchor-text\">[216]<\/span><\/a>\u3002\u30a2\u30b9\u30c8\u30e9\u30ac\u30ed\u30b7\u30c9 IV \u306b\u306f\u3055\u307e\u3056\u307e\u306a\u7a2e\u985e\u304c\u3042\u308a\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u751f\u7269\u6d3b\u52d5\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/biological-activity\">\u751f\u7269\u5b66\u7684\u6d3b\u52d5<\/a>\u3001\u7814\u7a76\u7bc4\u56f2\u306b\u306f\u8133\u3001\u809d\u81d3\u3001\u5fc3\u81d3\u3001\u80ba\u3001\u814e\u81d3\u3001\u80c3\u3001\u8178\u3001\u8840\u7ba1\u306a\u3069\u306e\u8907\u6570\u306e\u81d3\u5668\u3084\u7d44\u7e54\u304c\u542b\u307e\u308c\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib217\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib217\"><span class=\"anchor-text\">[217]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib218\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib218\"><span class=\"anchor-text\">[218]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib219\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib219\"><span class=\"anchor-text\">[219]<\/span><\/a>\u00a0\u6297\u708e\u75c7\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u3001\u6297\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3001\u4fc3\u9032\u306a\u3069\u306e\u751f\u7269\u5b66\u7684\u6d3b\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u7d30\u80de\u5897\u6b96\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-proliferation\">\u7d30\u80de\u5897\u6b96<\/a>\u3001\u898f\u5236\u3059\u308b\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30a6\u30b5\u30ae\u306e\u75c5\u6c17\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/rabbit-disease\">\u30a6\u30b5\u30ae\u306e\u75c5\u6c17<\/a>\u8840\u7cd6\u5024\u3092\u8abf\u7bc0\u3057\u3001\u8001\u5316\u3092\u9045\u3089\u305b\u3001\u304c\u3093\u3092\u6291\u5236\u3059\u308b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib217\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib217\"><span class=\"anchor-text\">[217]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib218\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib218\"><span class=\"anchor-text\">[218]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib219\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib219\"><span class=\"anchor-text\">[219]<\/span><\/a>\u3002\u79c1\u305f\u3061\u306e\u4ee5\u524d\u306e\u7814\u7a76\u3067\u306f\u3001IS\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u6f5c\u5728\u7684\u306a\u795e\u7d4c\u4fdd\u8b77\u5264\u3068\u3057\u3066\u30a2\u30b9\u30c8\u30e9\u30ac\u30ed\u30b7\u30c9IV\u304c\u7279\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u4f8b\u3048\u3070\u3001\u8840\u6db2\u8133\u95a2\u9580\u3092\u4fdd\u8b77\u3057\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3092\u6539\u5584\u3057\u3001\u795e\u7d4c\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u6291\u5236\u3057\u3001\u708e\u75c7\u53cd\u5fdc\u3084\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u6291\u5236\u3057\u3001\u795e\u7d4c\u4fdd\u8b77\u52b9\u679c\u3092\u767a\u63ee\u3057\u3066\u8133\u865a\u8840\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib220\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib220\"><span class=\"anchor-text\">[220]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib221\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib221\"><span class=\"anchor-text\">[221]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib222\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib222\"><span class=\"anchor-text\">[222]<\/span><\/a>\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306b\u95a2\u3057\u3066\u306f\u3001Tang\u3089\u306f\u3001\u30e9\u30c3\u30c8\u306e\u8133\u865a\u8840\u518d\u704c\u6d41\u4e2d\u306bNLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u304c\u6d3b\u6027\u5316\u3055\u308c\u3001NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u3092\u963b\u5bb3\u3059\u308b\u304b\u3001\u305d\u306e\u4e0b\u6d41\u306e\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3092\u963b\u5bb3\u3059\u308b\u3068\u3001\u30e9\u30c3\u30c8\u306e\u8133\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u3092\u8efd\u6e1b\u3067\u304d\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u305f\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib223\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib223\"><span class=\"anchor-text\">[223]<\/span><\/a>\u3002\u30a2\u30b9\u30c8\u30e9\u30ac\u30ed\u30b7\u30c9 IV \u306f\u3001\u795e\u7d4c\u969c\u5bb3\u30b9\u30b3\u30a2\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u8133\u6897\u585e\u306e\u5bb9\u7a4d\u3092\u6e1b\u5c11\u3055\u305b\u3001\u8133\u7d44\u7e54\u306b\u304a\u3051\u308b NLRP3\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3001\u30d7\u30ed IL-1\u03b2\u3001IL-1\u03b2\u3001\u30d7\u30ed IL-18\u3001\u304a\u3088\u3073 IL-18 \u306e\u30bf\u30f3\u30d1\u30af\u8cea\u30ec\u30d9\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 \u3001\u30ea\u30f3\u9178\u5316\u3055\u308c\u305fNF-\u03baB\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u3092\u963b\u5bb3\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u30a2\u30b9\u30c8\u30e9\u30ac\u30ed\u30b7\u30c9 IV \u306b\u306f\u6297 CIRI \u52b9\u679c\u304c\u3042\u308a\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f NF-\u03baB \u306e\u963b\u5bb3\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30bf\u30f3\u30d1\u30af\u8cea\u30ea\u30f3\u9178\u5316\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/protein-phosphorylation\">\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ea\u30f3\u9178\u5316<\/a>\u00a0NLRP3 \u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u6d3b\u6027\u5316\u306e\u963b\u5bb3\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib223\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib223\"><span class=\"anchor-text\">[223]<\/span><\/a>\u3002\u30ea\u30fc\u3089\u3002\u307e\u305f\u3001\u30a2\u30b9\u30c8\u30e9\u30ac\u30ed\u30b7\u30c9 IV \u304c\u65b0\u751f\u4ed4\u30e9\u30c3\u30c8\u306e\u4f4e\u9178\u7d20\u865a\u8840\u8a98\u767a\u6027\u8133\u640d\u50b7\u3092\u8efd\u6e1b\u3057\u3001MMP-9 \u5a92\u4ecb NLRP3\/\u30ab\u30b9\u30d1\u30fc\u30bc-1 \u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib224\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib224\"><span class=\"anchor-text\">[224]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0155\">\n<h4 id=\"sect0175\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.11.\u30aa\u30bf\u30cd\u30cb\u30f3\u30b8\u30f3\u30b5\u30dd\u30cb\u30f3 (PNS)<\/h4>\n<p id=\"p0210\"><em>\u4e09\u4e03\u4eba\u53c2\u6839\u830e<\/em>\u00a0\u4e7e\u71e5\u3057\u305f\u6839\u3067\u3042\u308a\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u6839\u830e\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/rhizome\">\u6839\u830e<\/a>\u00a0\u306e\u00a0<em><a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089 Panax \u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/panax\">\u30aa\u30bf\u30cd\u30cb\u30f3\u30b8\u30f3<\/a><\/em><em>\u00a0\u80fd\u767b\u9280\u6cc9\uff08\u30d0\u30fc\u30af\uff09<\/em>\u00a0FH Chen\u3001\u8840\u6db2\u3001\u5fc3\u8840\u7ba1\u3001\u795e\u7d4c\u3001\u514d\u75ab\u7cfb\u306b\u85ac\u7406\u6d3b\u6027\u3092\u6709\u3059\u308b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib225\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib225\"><span class=\"anchor-text\">[225]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib226\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib226\"><span class=\"anchor-text\">[226]<\/span><\/a>PNS\u306f\u4e3b\u306a\u6709\u52b9\u6210\u5206\u3067\u3042\u308a\u3001\u3055\u307e\u3056\u307e\u306a\u30e2\u30ce\u30de\u30fc\u30b5\u30dd\u30cb\u30f3\u3092\u542b\u307f\u3001\u305d\u306e\u88fd\u5264\u3001\u4f8b\u3048\u3070\u859b\u658e\u901a\u6ce8\u5c04\u6db2\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3084\u8133\u8840\u7ba1\u75be\u60a3\u306e\u4e88\u9632\u3068\u6cbb\u7642\u306b\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib227\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib227\"><span class=\"anchor-text\">[227]<\/span><\/a>\u3002\u79c1\u305f\u3061\u306e\u4ee5\u524d\u306e\u7814\u7a76\u3068\u65e2\u5b58\u306e\u7814\u7a76\u306f\u3001PNS\u304c\u865a\u8840\u6027\u8133\u640d\u50b7\u306b\u5bfe\u3057\u3066\u3055\u307e\u3056\u307e\u306a\u85ac\u7406\u5b66\u7684\u52b9\u679c\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u6297\u8840\u6813\u85ac\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antithrombotic\">\u6297\u8840\u6813\u85ac<\/a>\u6297\u708e\u75c7\u3001\u6297\u9178\u5316\u4f5c\u7528\u3001\u8133\u795e\u7d4c\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u6291\u5236\u3001\u8840\u6db2\u8133\u95a2\u9580\u306e\u640d\u50b7\u6539\u5584\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib228\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib228\"><span class=\"anchor-text\">[228]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib229\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib229\"><span class=\"anchor-text\">[229]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib230\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib230\"><span class=\"anchor-text\">[230]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib231\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib231\"><span class=\"anchor-text\">[231]<\/span><\/a>\u3053\u308c\u306f\u3001PNS\u304c\u8907\u6570\u306e\u6a19\u7684\u3092\u4ecb\u3057\u3066\u8133\u865a\u8840\u306e\u4fdd\u8b77\u7684\u5f79\u5272\u3092\u679c\u305f\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001PNS\u304cNLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u6d3b\u6027\u5316\u3092\u963b\u5bb3\u3057\u3001\u9078\u629e\u7684\u306b\u4fc3\u9032\u3067\u304d\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u308b\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitophagy\">\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc<\/a>\u00a0\u30e9\u30c3\u30c8\u306e\u8133\u865a\u8840\u518d\u704c\u6d41\u4e2d\u3002\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u963b\u5bb3\u3059\u308b\u3068\u3001NLRP3 \u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306b\u5bfe\u3059\u308b PNS \u306e\u963b\u5bb3\u52b9\u679c\u304c\u9006\u8ee2\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u304c\u8133\u865a\u8840\u518d\u704c\u6d41\u306b\u304a\u3051\u308b NLRP3 \u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u6d3b\u6027\u5316\u306b\u5bfe\u3059\u308b PNS \u306e\u963b\u5bb3\u52b9\u679c\u3092\u5a92\u4ecb\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u30e9\u30c3\u30c8\u306e\u8133\u865a\u8840\u518d\u704c\u6d41\u4e2d\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5185\u306ePINK1\u304a\u3088\u3073Parkin\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ec\u30d9\u30eb\u304c\u5897\u52a0\u3057\u3001PNS\u306f\u8133\u7d44\u7e54\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5185\u306ePINK1\u304a\u3088\u3073Parkin\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ec\u30d9\u30eb\u3092\u3055\u3089\u306b\u5897\u52a0\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u3053\u308c\u306f\u3001PNS \u304c PINK1\/Parkin \u7d4c\u8def\u3092\u4ecb\u3057\u3066\u8133\u865a\u8840\u518d\u704c\u6d41\u306b\u304a\u3051\u308b\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u4fc3\u9032\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib232\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib232\"><span class=\"anchor-text\">[232]<\/span><\/a>\u8981\u7d04\u3059\u308b\u3068\u3001PNS \u306f PINK1\/Parkin \u7d4c\u8def\u3092\u4ecb\u3057\u3066\u30df\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u9078\u629e\u7684\u306b\u4fc3\u9032\u3057\u3001\u8133\u865a\u8840\u518d\u704c\u6d41\u306b\u304a\u3051\u308b NLRP3 \u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u6d3b\u6027\u5316\u3092\u963b\u5bb3\u3057\u3001\u8133\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u3092\u8efd\u6e1b\u3057\u307e\u3059\u3002<\/p>\n<\/section>\n<\/section>\n<section id=\"sec0160\">\n<h3 id=\"sect0180\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">5.2. \u5929\u7136\u690d\u7269\u30a8\u30ad\u30b9<\/h3>\n<section id=\"sec0165\">\n<h4 id=\"sect0185\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.1.\u30bf\u30aa\u30db\u30f3\u30b7\u30a6\u714e\u3058\u85ac (THSWD)<\/h4>\n<p id=\"p0215\">THSWD \u306f\u3001\u8840\u6db2\u5faa\u74b0\u3092\u4fc3\u9032\u3057\u3001\u8840\u6db2\u306e\u5faa\u74b0\u3092\u4fc3\u9032\u3057\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u8840\u6db2\u3046\u3063\u6ede\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/blood-stasis\">\u8840\u6db2\u3046\u3063\u6ede<\/a>\u6e05\u671d\u306e\u5449\u8b19\u306e\u300c\u533b\u85ac\u91d1\u93e1\u300d\u306b\u3088\u3063\u3066\u4f5c\u3089\u308c\u305f\u3001\u8840\u6db2\u306e\u505c\u6ede\u3092\u53d6\u308a\u9664\u304d\u3001\u65b0\u3057\u3044\u8840\u6db2\u3092\u518d\u751f\u3059\u308b\u3002\u73fe\u5728\u306e\u85ac\u7406\u5b66\u7684\u7814\u7a76\u3067\u306f\u3001THSWD\u306e\u4e3b\u306a\u6709\u52b9\u6210\u5206\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30d5\u30a7\u30eb\u30e9\u9178\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ferulic-acid\">\u30d5\u30a7\u30eb\u30e9\u9178<\/a>,\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30d9\u30cb\u30d0\u30ca\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/safflower\">\u30d9\u30cb\u30d0\u30ca<\/a>\u00a0\u9ec4\u8272\u3068\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u591a\u7cd6\u985e\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glycan\">\u591a\u7cd6\u985e<\/a>\u305d\u306e\u4e2d\u3067\u3001\u30d5\u30a7\u30eb\u30e9\u9178\u306f\u3001\u8840\u5c0f\u677f\u51dd\u96c6\u6291\u5236\u3001\u6297\u8840\u6813\u3001\u6297\u708e\u75c7\u3001\u6297\u9178\u5316\u306a\u3069\u306e\u85ac\u7406\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002\u7d05\u82b1\u9ec4\u306b\u306f\u3001\u6297\u8133\u865a\u8840\u3001\u6297\u5fc3\u7b4b\u865a\u8840\u3001\u6297\u8840\u6813\u3001\u6297\u9178\u5316\u3001\u6297\u816b\u760d\u306a\u3069\u306e\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002\u5468\u3089\u306f\u3001THSWD\u304c\u8133\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u5f8c\u306e\u795e\u7d4c\u6b20\u640d\u6a5f\u80fd\u3001\u8133\u6897\u585e\u5bb9\u7a4d\u3001\u8133\u7d44\u7e54\u5f62\u614b\u3092\u6539\u5584\u3057\u3001DRP1\u3001NLRP3\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3001IL-1\u03b2\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ec\u30d9\u30eb\u3092\u5927\u5e45\u306b\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib233\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib233\"><span class=\"anchor-text\">[233]<\/span><\/a>\u3002\u3053\u308c\u306f\u3001\u8133\u6897\u585e\u306b\u5bfe\u3059\u308bTHSWD\u306e\u6cbb\u7642\u52b9\u679c\u304c\u3001\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306b\u95a2\u9023\u3059\u308bDRP1\/NLRP3\u7d4c\u8def\u306e\u963b\u5bb3\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u3055\u3089\u306a\u308b\u7814\u7a76\u306b\u3088\u308a\u3001THSWD \u30b0\u30eb\u30fc\u30d7\u306e IL-1\u03b2 \u304a\u3088\u3073 IL-18 \u306e\u542b\u6709\u91cf\u304c\u5927\u5e45\u306b\u6e1b\u5c11\u3057\u3001NLRP3\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-1 p10\u3001ASC\u3001TXNIP\u3001\u304a\u3088\u3073 GSDMD \u306e\u30ec\u30d9\u30eb\u304c\u6e1b\u5c11\u3057\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u691c\u51fa\u306b\u3088\u308a\u3001THSWD \u304c HMGB1\/RAGE\u3001TLR4\/NF-\u03baB\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089 p38 MAPK \u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/p38-mitogen-activated-protein-kinase\">p38 MAPK<\/a>\u00a0\u305d\u3057\u3066\u534a\u5f71\u306b\u3042\u308bJNK\u3002\u8981\u7d04\u3059\u308b\u3068\u3001THSWD \u306f MCAO\/R \u30e9\u30c3\u30c8\u306e\u708e\u75c7\u53cd\u5fdc\u30ec\u30d9\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\u3001MCAO\/R \u30e9\u30c3\u30c8\u306e NLRP3 \u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u6d3b\u6027\u5316\u3092\u963b\u5bb3\u3057\u3001GSMDD \u3092\u4e0b\u65b9\u5236\u5fa1\u3057\u307e\u3057\u305f\u3002 THSWD \u306b\u306f\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u963b\u5bb3\u3059\u308b\u52b9\u679c\u304c\u3042\u308a\u3001\u3053\u308c\u306f HMGB1\/TLR4\/NF-kB \u304a\u3088\u3073 MAPK \u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u963b\u5bb3\u306b\u3088\u3063\u3066\u5f71\u97ff\u3092\u53d7\u3051\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib234\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib234\"><span class=\"anchor-text\">[234]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0170\">\n<h4 id=\"sect0190\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.2. \u30ca\u30aa\u30b7\u30f3\u30c1\u30f3\u30ab\u30d7\u30bb\u30eb\uff08NXQC\uff09<\/h4>\n<p id=\"p0220\">NXQC\u306e\u4e3b\u6210\u5206\u306f\u3001\u00a0<em><a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089 Diospyros kaki \u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/persimmon\">\u30c7\u30a3\u30aa\u30b9\u30d4\u30ed\u30b9\u30ab\u30ad<\/a><\/em>\u00a0\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u67ff\u306e\u8449\u30a8\u30ad\u30b9\u306b\u306f\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u3001\u6709\u6a5f\u9178\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30af\u30de\u30ea\u30f3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/coumarin\">\u30af\u30de\u30ea\u30f3<\/a>\u00a0\u6297\u708e\u75c7\u4f5c\u7528\u3001\u6297\u9178\u5316\u4f5c\u7528\u3001\u305d\u306e\u4ed6\u306e\u5316\u5b66\u7269\u8cea\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u964d\u5727\u5264\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antihypertensive-agent\">\u964d\u5727\u5264<\/a>\u3001\u8840\u4e2d\u8102\u8cea\u306e\u4f4e\u4e0b\u3001\u6539\u5584\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u8840\u7ba1\u5e73\u6ed1\u7b4b\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascular-smooth-muscle\">\u8840\u7ba1\u5e73\u6ed1\u7b4b<\/a>\u00a0\u6a5f\u80fd\u3068\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u8840\u884c\u52d5\u614b\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hemodynamic\">\u8840\u884c\u52d5\u614b<\/a>\u00a0\u95a2\u6570\u3002\u3053\u306e\u85ac\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u3084\u8133\u8840\u7ba1\u75be\u60a3\u306e\u6cbb\u7642\u306b\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib235\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib235\"><span class=\"anchor-text\">[235]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib236\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib236\"><span class=\"anchor-text\">[236]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib237\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib237\"><span class=\"anchor-text\">[237]<\/span><\/a>\u65e2\u5b58\u306e\u7814\u7a76\u3067\u306f\u3001NXQC\u304c\u52b9\u679c\u7684\u306b\u6539\u5584\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u8133\u52d5\u8108\u786c\u5316\u75c7\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebral-atherosclerosis\">\u8133\u52d5\u8108\u786c\u5316\u75c7<\/a>\u00a0\u8133\u865a\u8840\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u795e\u7d4c\u640d\u50b7\u3092\u4fdd\u8b77\u3057\u307e\u3059\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib238\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib238\"><span class=\"anchor-text\">[238]<\/span><\/a>\u3002\u30df\u30f3\u3089\u3002 NXQC\u306f\u8133\u865a\u8840\u5f8c\u306e\u5b66\u7fd2\u80fd\u529b\u306e\u4f4e\u4e0b\u3092\u52b9\u679c\u7684\u306b\u6539\u5584\u3057\u3001\u8133\u306e\u6d3b\u52d5\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b7\u30c9\u30c7\u30a3\u30b9\u30e0\u30bf\u30fc\u30bc\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/superoxide-dismutase\">\u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b7\u30c9\u30b8\u30b9\u30e0\u30bf\u30fc\u30bc<\/a>\u00a0\u305d\u3057\u3066\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u4e73\u9178\u30c7\u30d2\u30c9\u30ed\u30b2\u30ca\u30fc\u30bc\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/lactate-dehydrogenase\">\u4e73\u9178\u8131\u6c34\u7d20\u9175\u7d20<\/a>\u3001GSH\u306e\u542b\u6709\u91cf\u3092\u5897\u3084\u3057\u3001\u306e\u542b\u6709\u91cf\u3092\u6e1b\u3089\u3057\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30de\u30ed\u30f3\u30b8\u30a2\u30eb\u30c7\u30d2\u30c9\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/malonaldehyde\">\u30de\u30ed\u30f3\u30b8\u30a2\u30eb\u30c7\u30d2\u30c9<\/a>NXQC\u306f\u6d77\u99ac\u306eASC\u3001NLRP3\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-1\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u3092\u4f4e\u4e0b\u3055\u305b\u3001IL-18\u3068IL-1\u03b2\u306e\u542b\u6709\u91cf\u3092\u5927\u5e45\u306b\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u3082\u3067\u304d\u308b\u3002\u307e\u305f\u3001NXQC\u306e\u4ecb\u5165\u5f8c\u306b\u30b9\u30ca\u30cd\u30ba\u30df\u306e\u8840\u5c0f\u677f\u5185\u76ae\u7d30\u80de\u63a5\u7740\u5206\u5b50-1\u967d\u6027\u7d30\u80de\u304c\u6709\u610f\u306b\u5897\u52a0\u3057\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u7d30\u80de\u9593\u7d50\u5408\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-junction\">\u7d30\u80de\u9593\u7d50\u5408<\/a>\u00a0NXQC\u306f\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u6d77\u99ac CA1 \u9818\u57df\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/sommers-sector\">\u6d77\u99acCA1\u9818\u57df<\/a>\u00a0\u30b9\u30ca\u30cd\u30ba\u30df\u306e\u8133\u8840\u7ba1\u6a5f\u80fd\u3092\u4fdd\u8b77\u3057\u3001\u8133\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u3092\u6291\u5236\u3059\u308b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib239\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib239\"><span class=\"anchor-text\">[239]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0175\">\n<h4 id=\"sect0195\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.3.\u8299\u84c9\u9ec4\u6e6f\u714e\u3058\u85ac\uff08BYHWD\uff09\u3068\u305d\u306e\u6539\u826f\u54c1<\/h4>\n<p id=\"p0225\">BYHWD\u306f\u6709\u540d\u3067\u3059\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u4f1d\u7d71\u7684\u306a\u4e2d\u56fd\u533b\u5b66\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/traditional-chinese-medicine\">\u4f1d\u7d71\u7684\u306a\u4e2d\u56fd\u533b\u5b66<\/a>\u00a0\u8133\u5352\u4e2d\u306e\u6cbb\u7642\u306b\u4f7f\u7528\u3055\u308c\u308b\u51e6\u65b9\u3002\u305d\u306e\u51e6\u65b9\u306f\u6e05\u671d\u306e\u738b\u6e05\u4ec1\u306e\u300e\u533b\u7d4c\u6b63\u6b63\u300f\u306b\u521d\u3081\u3066\u8a18\u9332\u3055\u308c\u305f\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib240\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib240\"><span class=\"anchor-text\">[240]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib241\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib241\"><span class=\"anchor-text\">[241]<\/span><\/a>\u3002\u6c17\u3092\u990a\u3044\u3001\u8840\u6db2\u3092\u6d3b\u6027\u5316\u3059\u308b\u51e6\u65b9\u306e\u4ee3\u8868\u7684\u306a\u3082\u306e\u3067\u3059\u3002\u6c17\u3092\u5f37\u5316\u3057\u3001\u8840\u6db2\u5faa\u74b0\u3092\u4fc3\u9032\u3057\u3001\u5074\u526f\u3092\u6d5a\u6e2b\u3059\u308b\u6a5f\u80fd\u304c\u3042\u308a\u307e\u3059\u3002\u79d1\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u3044\u305f\u533b\u5b66\u7814\u7a76\u3067\u826f\u597d\u306a\u81e8\u5e8a\u52b9\u679c\u304c\u8a3c\u660e\u3055\u308c\u3066\u3044\u307e\u3059\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib242\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib242\"><span class=\"anchor-text\">[242]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib243\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib243\"><span class=\"anchor-text\">[243]<\/span><\/a>\u524d\u56de\u306e\u7814\u7a76\u3067\u306f\u3001BYHWD\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u914d\u7cd6\u4f53\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glycoside\">\u914d\u7cd6\u4f53<\/a>\u00a0\u795e\u7d4c\u6a5f\u80fd\u4e0d\u5168\u3092\u6539\u5584\u3057\u3001\u795e\u7d4c\u7d30\u80de\u306e\u640d\u50b7\u3092\u8efd\u6e1b\u3057\u3001\u795e\u7d4c\u7d30\u80de\u306e\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u6291\u5236\u3057\u307e\u3059\u3002 BYHWD \u914d\u7cd6\u4f53\u306f\u3001BYHWD \u304b\u3089\u62bd\u51fa\u3055\u308c\u305f\u6709\u52b9\u6210\u5206\u3067\u3001\u4e3b\u306b\u30a2\u30b9\u30c8\u30e9\u30ac\u30ed\u30b7\u30c9 IV\u3001\u30da\u30aa\u30cb\u30d5\u30ed\u30ea\u30f3\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30a2\u30df\u30b0\u30c0\u30ea\u30f3\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/amygdalin\">\u30a2\u30df\u30b0\u30c0\u30ea\u30f3<\/a>\u3002\u814e\u81d3\u3092\u5f37\u5316\u3057\u3001\u8840\u6db2\u3092\u6d3b\u6027\u5316\u3059\u308b\u4e3b\u306a\u85ac\u7406\u6d3b\u6027\u6210\u5206\u3067\u3042\u308a\u3001\u8133\u865a\u8840\u6027\u795e\u7d4c\u640d\u50b7\u3092\u6cbb\u7642\u3067\u304d\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib244\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib244\"><span class=\"anchor-text\">[244]<\/span><\/a>\u3002\u3055\u3089\u306b\u3001BYHWD \u30b0\u30ea\u30b3\u30b7\u30c9\u304c\u3001NLRP3 \u5a92\u4ecb\u6a19\u6e96\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u306e NLRP3\u3001ASC\u3001\u30d7\u30ed\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3001\u304a\u3088\u3073 IL-1\u03b2 \u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u3092\u6709\u610f\u306b\u963b\u5bb3\u3059\u308b\u3053\u3068\u3092\u89b3\u5bdf\u3057\u307e\u3057\u305f\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib209\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib209\"><span class=\"anchor-text\">[209]<\/span><\/a>\u8981\u7d04\u3059\u308b\u3068\u3001BYHWD\u30b0\u30ea\u30b3\u30b7\u30c9\u306fCIRI\u5f8c\u306e\u795e\u7d4c\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u795e\u7d4c\u4fdd\u8b77\u52b9\u679c\u3092\u767a\u63ee\u3057\u3001\u3053\u308c\u306fNLRP3\u306b\u3088\u308b\u53e4\u5178\u7684\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u306e\u8abf\u7bc0\u3068\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3002\u3055\u3089\u306b\u3001Longzhi\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089Decoction\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/decoction\">\u714e\u3058\u85ac<\/a>\u00a0\u306f\u3001BYHWD \u304c\u30d2\u30eb\u3068\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30a2\u30ad\u30e9\u30f3\u30c6\u30b9\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/achyranthes\">\u30a2\u30ad\u30e9\u30f3\u30c6\u30b9<\/a>\u00a0\u30b7\u30c1\u30e5\u30cd\u30f3\u30b7\u30b9\u3002\u6025\u6027\u8133\u5352\u4e2d\u306e\u81e8\u5e8a\u6cbb\u7642\u306b\u9577\u5e74\u4f7f\u7528\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u52b9\u679c\u306f\u975e\u5e38\u306b\u826f\u597d\u3067\u3059\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib245\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib245\"><span class=\"anchor-text\">[245]<\/span><\/a>\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u9f8d\u829d\u714e\u3058\u6db2\u306f\u30e9\u30c3\u30c8\u306eCIRI\u5f8c\u306e\u795e\u7d4c\u75c7\u72b6\u306e\u6539\u5584\u3001\u8133\u7d44\u7e54\u306e\u795e\u7d4c\u7d30\u80de\u306e\u72b6\u614b\u306e\u7dad\u6301\u3001\u8133\u6897\u585e\u306e\u5bb9\u7a4d\u306e\u6e1b\u5c11\u306b\u660e\u3089\u304b\u306a\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4ecb\u5165\u7d30\u80de\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306e\u89b3\u70b9\u304b\u3089\u3001\u9f8d\u829d\u714e\u3058\u6db2\u306f\u30e9\u30c3\u30c8\u306eCIRI\u5f8c\u306e\u75c7\u72b6\u3092\u6539\u5584\u3057\u3001\u8133\u3092\u4fdd\u8b77\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u795e\u7d4c\u7d30\u80de\u306e\u640d\u50b7\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nerve-cell-lesion\">\u795e\u7d4c\u7d30\u80de\u306e\u640d\u50b7<\/a>\u00a0\u50b7\u5bb3\u5f8c\u306b\u30ab\u30b9\u30d1\u30fc\u30bc1\u3068IL-18\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib245\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib245\"><span class=\"anchor-text\">[245]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0180\">\n<h4 id=\"sect0200\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.4.\u6613\u6c17\u706b\u6bd2\u51e6\u65b9\uff08YQHXP\uff09<\/h4>\n<p id=\"p0230\">YQHXP\u306f\u00a0<em>\u5f53\u5e30\u3001\u9ec4\u8006\u3001\u00a0<\/em><em><a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089 Chuanxiong Rhizoma \u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ligusticum-chuanxiong-extract\">\u5ddd\u8292<\/a><\/em><em>\u3001\u880d\u5ea7\u3001\u30ec\u30aa\u30cc\u30ea\u30fb\u30cf\u30fc\u30d6\u3001\u30a2\u30b3\u30ea\u30fb\u30bf\u30bf\u30ea\u30ce\u30a6\u30a3\u30fb\u30ea\u30be\u30de\u3001\u30dc\u30eb\u30cd\u30aa\u30e9\u30e0\u30fb\u30b7\u30f3\u30bb\u30c6\u30a3\u30a6\u30e0<\/em>\u3001\u826f\u597d\u306a\u81e8\u5e8a\u7d50\u679c\u3092\u9054\u6210\u3057\u3066\u3044\u308b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib246\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib246\"><span class=\"anchor-text\">[246]<\/span><\/a>\u3002\u52d5\u7269\u5b9f\u9a13\u3067\u306f\u3001YQHXP\u304c\u30e9\u30c3\u30c8\u306e\u795e\u7d4c\u6a5f\u80fd\u30b9\u30b3\u30a2\u3068\u8133\u6897\u585e\u7387\u3092\u6539\u5584\u3057\u3001\u8133\u7d44\u7e54\u306eIL-1\u03b2\u3001TNF-\u03b1\u3001IL-18\u306e\u30ec\u30d9\u30eb\u3068IL-18\u306e\u76f8\u5bfe\u767a\u73fe\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089P2RX7\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/p2rx7\">P2RX7<\/a>\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-11\u3001\u304a\u3088\u3073GSDMD\u304c\u8133\u865a\u8840\u6027\u5468\u7e01\u7d44\u7e54\u3067\u5897\u52a0\u3057\u305f\u3002YQHXP\u4ecb\u5165\u5f8c\u3001\u8133\u7d44\u7e54\u306e\u708e\u75c7\u6027\u6ef2\u51fa\u6db2\u3068\u6d6e\u816b\u304c\u5927\u5e45\u306b\u6e1b\u5c11\u3057\u3001\u7d30\u80de\u5f62\u614b\u3068\u795e\u7d4c\u7a7a\u80de\u5909\u6027\u304c\u6539\u5584\u3057\u305f\u3002\u8981\u7d04\u3059\u308b\u3068\u3001YQHXP\u306f\u3001\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u3001\u6025\u6027\u865a\u8840\u6027\u8133\u5352\u4e2d\u30e9\u30c3\u30c8\u306e\u8133\u7d44\u7e54\u306e\u708e\u75c7\u3092\u8efd\u6e1b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib247\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib247\"><span class=\"anchor-text\">[247]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0185\">\n<h4 id=\"sect0205\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.5.\u6c88\u5c1a\u798f\u6e90\u714e\u3058\u85ac (SNFYD)<\/h4>\n<p id=\"p0235\">SNFYD \u306f\u3001\u814e\u81d3\u3068\u8133\u306e\u540c\u6642\u6cbb\u7642\u7406\u8ad6\u306b\u57fa\u3065\u3044\u305f\u865a\u8840\u6027\u8133\u5352\u4e2d\u306b\u52b9\u679c\u7684\u306a\u51e6\u65b9\u85ac\u3067\u3059\u3002\u305d\u306e\u6210\u5206\u306f\u6b21\u306e\u3068\u304a\u308a\u3067\u3059\u3002\u00a0<em>\u9ec4\u8006<\/em>\u00a030\u30b0\u30e9\u30e0<em>,\u00a0<\/em><em><a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089 Rehmanniae \u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/rehmannia\">\u30b8\u30aa\u30a6<\/a><\/em><em>\u00a0\u57fa\u6570\u30d7\u30e9\u30a8\u30d1\u30e9\u30bf<\/em>\u00a010g<em>\u3001\u30b3\u30eb\u30cb\u30d5\u30eb\u30af\u30c8\u30a5\u30b9<\/em>\u00a010g<em>\u3001\u30e4\u30de\u30ce\u30a4\u30e2\u79d1\u306e\u6839\u830e<\/em>\u00a015\u30b0\u30e9\u30e0<em>\u3001\u30a4\u30ef\u30d9\u30f3\u30b1\u30a4\u3001\u30a4\u30ef\u30d9\u30f3\u30b1\u30a4\u3001\u6839\u830e\u304a\u3088\u3073\u6839\u830e<\/em>\u00a020\u30b0\u30e9\u30e0<em>,\u00a0<\/em><em><a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089 Moutan Cortex \u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/moutan-cortex\">\u7261\u4e39\u76ae<\/a><\/em>\u00a010g<em>\u3001\u5f53\u5e30<\/em>\u00a010g<em>\u3001\u30dc\u30bf\u30f3\u3001Radix Rubra<\/em>\u00a010g<em>,\u00a0<\/em><em><a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u30d5\u30a7\u30ec\u30c6\u30a3\u30de\u306e\u8a73\u7d30\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/pheretima\">\u30d5\u30a7\u30ec\u30c6\u30a3\u30de<\/a><\/em>\u00a010g\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib248\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib248\"><span class=\"anchor-text\">[248]<\/span><\/a>\u6c17\u3092\u5f37\u3081\u3001\u7cbe\u3092\u88dc\u3044\u3001\u814e\u3092\u5f37\u3081\u308b\u85ac\u3092\u591a\u6570\u914d\u5408\u3057\u3001\u8840\u6db2\u3092\u6d3b\u6027\u5316\u3057\u3001\u5074\u526f\u8840\u884c\u8def\u3092\u6d5a\u6e2b\u3059\u308b\u3002\u7814\u7a76\u306b\u3088\u308b\u3068\u3001OGD\u30e2\u30c7\u30ea\u30f3\u30b0\u5f8c\u3001PC12\u306f\u8457\u3057\u304f\u640d\u50b7\u3057\u3001\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u306e\u3055\u307e\u3056\u307e\u306a\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304c\u5927\u5e45\u306b\u5897\u52a0\u3057\u305f\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib249\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib249\"><span class=\"anchor-text\">[249]<\/span><\/a>\u3002 SNFYD\u542b\u6709\u8840\u6e05\u3068INF39\u304c\u640d\u50b7\u90e8\u4f4d\u306b\u4ecb\u5165\u3057\u305f\u5f8c\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089 PC12 \u7d30\u80de\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pc12-cell-line\">PC12\u7d30\u80de<\/a>\u3001PC12\u7d30\u80de\u306e\u5f62\u614b\u3068\u6d3b\u6027\u304c\u6539\u5584\u3055\u308c\u3001\u305d\u308c\u306b\u5fdc\u3058\u3066NLRP3\/\u30ab\u30b9\u30d1\u30fc\u30bc-1\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u304c\u5f31\u307e\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u3053\u306e\u7d4c\u8def\u306e\u963b\u5bb3\u304c\u7d30\u80de\u72b6\u614b\u306e\u6539\u5584\u306b\u95a2\u9023\u3057\u3066\u304a\u308a\u3001SNFYD \u3068 INF39 \u306e\u4e21\u65b9\u304c\u3053\u306e\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u3092\u963b\u5bb3\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002 SNFYD\u306f\u3001NLRP3\/\u30ab\u30b9\u30d1\u30fc\u30bc-1\u304a\u3088\u3073\u4e0b\u6d41\u306e\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u795e\u7d4c\u7d30\u80de\u306e\u708e\u75c7\u6027\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u8efd\u6e1b\u3057\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u795e\u7d4c\u7d44\u7e54\u3092\u4fdd\u8b77\u3057\u3001\u8133\u6897\u585e\u306e\u6cbb\u7642\u3068\u3044\u3046\u76ee\u7684\u3092\u9054\u6210\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib250\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib250\"><span class=\"anchor-text\">[250]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0190\">\n<h4 id=\"sect0210\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.6. \u305d\u306e\u4ed6\u306e\u629c\u7c8b<\/h4>\n<p id=\"p0240\">\u3055\u3089\u306b\u3001\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u30d8\u30d1\u30ea\u30f3\u306a\u3069\u306e\u6297\u8840\u6813\u85ac\u304c\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u80ba\u640d\u50b7\u3092\u6539\u5584\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u30e4\u30f3\u3089\u3002\u30d8\u30d1\u30ea\u30f3\u306f\u3001hMGB1 LPS \u8a98\u5c0e\u6027\u306e\u30ab\u30b9\u30d1\u30fc\u30bc 11 \u6d3b\u6027\u5316\u3092\u30d6\u30ed\u30c3\u30af\u3059\u308b\u3053\u3068\u3067\u80ba\u5185\u76ae\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u6557\u8840\u75c7\u8a98\u5c0e\u6027\u306e\u80ba\u640d\u50b7\u3092\u6cbb\u7642\u3059\u308b\u6f5c\u5728\u7684\u306a\u65b9\u6cd5\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib251\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib251\"><span class=\"anchor-text\">[251]<\/span><\/a>Prathapan\u3089\u306f\u3001\u30b3\u30b3\u30ca\u30c3\u30c4\u30a6\u30a9\u30fc\u30bf\u30fc\u304c\u6297\u9178\u5316\u4f5c\u7528\u3068\u6297\u8840\u6813\u4f5c\u7528\u3092\u6301\u3064\u3053\u3068\u3092\u767a\u898b\u3057\u305f\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u5b9f\u9a13\u7684\u5fc3\u7b4b\u6897\u585e\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/experimental-myocardial-infarction\">\u5b9f\u9a13\u7684\u5fc3\u7b4b\u6897\u585e<\/a>\u00a0\u30e2\u30c7\u30eb\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib252\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib252\"><span class=\"anchor-text\">[252]<\/span><\/a>\u82e5\u3044\u30b3\u30b3\u30ca\u30c3\u30c4\u30b8\u30e5\u30fc\u30b9\u306f\u3001\u95a2\u9023\u3059\u308b\u75c5\u72b6\u306e\u3044\u304f\u3064\u304b\u3092\u5927\u5e45\u306b\u8efd\u6e1b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/alzheimer-disease\">\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib253\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib253\"><span class=\"anchor-text\">[253]<\/span><\/a>\u30b3\u30b3\u30ca\u30c3\u30c4\u6c34\u306f\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306e\u6f5c\u5728\u7684\u306a\u963b\u5bb3\u5264\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001IS \u306b\u304a\u3051\u308b\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306e\u8abf\u7bc0\u306b\u304a\u3051\u308b\u305d\u306e\u5f79\u5272\u304c\u5c06\u6765\u7814\u7a76\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/p>\n<p id=\"p0245\"><span class=\"small-caps\">\u3089<\/span>-\u30a2\u30eb\u30ae\u30cb\u30f3\u306f\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u30d7\u30ed\u30bf\u30df\u30f3\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/protamine\">\u30d7\u30ed\u30bf\u30df\u30f3<\/a>\u00a0\u5927\u91cf\u306b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib254\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib254\"><span class=\"anchor-text\">[254]<\/span><\/a>\u3053\u308c\u306f\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u4e00\u9178\u5316\u7a92\u7d20\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nitric-oxide\">\u4e00\u9178\u5316\u7a92\u7d20<\/a>\u00a0\uff08NO\uff09\u306f\u8840\u7ba1\u306e\u7121\u50b7\u306e\u5185\u76ae\u3092\u4fdd\u8b77\u3057\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u8840\u7ba1\u62e1\u5f35\u85ac\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vasodilator-agent\">\u8840\u7ba1\u62e1\u5f35\u5264<\/a>\u00a0\u5185\u56e0\u6027\u6297\u52d5\u8108\u786c\u5316\u5206\u5b50\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib254\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib254\"><span class=\"anchor-text\">[254]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib255\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib255\"><span class=\"anchor-text\">[255]<\/span><\/a>\u3002\u52d5\u7269\u5b9f\u9a13\u306b\u3088\u308b\u3068\u3001\u00a0<span class=\"small-caps\">\u3089<\/span>-\u30a2\u30eb\u30ae\u30cb\u30f3\u306f\u8907\u5408\u4f53\u3092\u6301\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u6297\u51dd\u56fa\u7642\u6cd5\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/anticoagulation\">\u6297\u51dd\u56fa\u4f5c\u7528<\/a>\u3001\u6297\u51dd\u56fa\u7642\u6cd5\u304a\u3088\u3073\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u7dda\u6eb6\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/fibrinolysis\">\u7dda\u7dad\u7d20\u6eb6\u89e3<\/a>\u00a0\u52b9\u679c\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib255\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib255\"><span class=\"anchor-text\">[255]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib256\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib256\"><span class=\"anchor-text\">[256]<\/span><\/a>\u3002\u9ad8\u8840\u5727\u30e9\u30c3\u30c8\u3067\u306f\u3001Cylwik et al.\u3042\u308c\u3092\u898b\u3064\u3051\u305f\u00a0<span class=\"small-caps\">\u3089<\/span>-\u30a2\u30eb\u30ae\u30cb\u30f3\u306f\u30e9\u30c3\u30c8\u306e\u8840\u5727\u3092\u4e0b\u3052\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u9577\u671f\u6cbb\u7642\u306b\u3088\u308a\u30e6\u30fc\u30b0\u30ed\u30d6\u30ea\u30f3\u8840\u6813\u6eb6\u89e3\u6642\u9593\u3068\u51fa\u8840\u6642\u9593\u304c\u77ed\u7e2e\u3055\u308c\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u8a98\u767a\u6027\u306e\u8840\u5c0f\u677f\u51dd\u96c6\u304c\u6291\u5236\u3055\u308c\u307e\u3057\u305f\u3002\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u306e\u306f\u3001\u00a0<span class=\"small-caps\">\u3089<\/span>-\u30a2\u30eb\u30ae\u30cb\u30f3\u306f\u9ad8\u8840\u5727\u30e9\u30c3\u30c8\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u6297\u8840\u6813\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u9759\u8108\u8840\u6813\u75c7\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/phlebothrombosis\">\u9759\u8108\u8840\u6813\u75c7<\/a>\u00a0\u8907\u96d1\u306a\u65b9\u6cd5\u3067\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib256\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib256\"><span class=\"anchor-text\">[256]<\/span><\/a>\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u00a0<span class=\"small-caps\">\u3089<\/span>-\u30a2\u30eb\u30ae\u30cb\u30f3\u306f\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u6f5c\u5728\u7684\u306a\u963b\u5bb3\u5264\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b: Tanuseputero et al.\u3068\u63d0\u6848\u3057\u305f\u00a0<span class=\"small-caps\">\u3089<\/span>-\u30a2\u30eb\u30ae\u30cb\u30f3\u306fNLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u3092\u90e8\u5206\u7684\u306b\u963b\u5bb3\u3057\u3066\u6557\u8840\u75c7\u8a98\u767a\u6027\u3092\u8efd\u6e1b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u6025\u6027\u814e\u969c\u5bb3\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/acute-kidney-injury\">\u6025\u6027\u814e\u969c\u5bb3<\/a>\u00a0\u30de\u30a6\u30b9\u3067\u306f\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib257\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib257\"><span class=\"anchor-text\">[257]<\/span><\/a>\u8840\u7ba1\u62e1\u5f35\u3001\u6297\u8840\u6813\u3001NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u963b\u5bb3\u6d3b\u6027\u3092\u8003\u616e\u3059\u308b\u3068\u3001\u00a0<span class=\"small-caps\">\u3089<\/span>-\u30a2\u30eb\u30ae\u30cb\u30f3\u306f\u3001\u00a0<span class=\"small-caps\">\u3089<\/span>-\u30a2\u30eb\u30ae\u30cb\u30f3\u306f\u3001\u865a\u8840\u9818\u57df\u306e\u8840\u6d41\u3092\u5897\u52a0\u3055\u305b\u3001IS\u306e\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u6291\u5236\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<div>\n<p id=\"p0250\">\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u5236\u5fa1\u3059\u308b\u5929\u7136\u7269\u306e\u6982\u8981\u3092\u4ee5\u4e0b\u306b\u793a\u3057\u307e\u3059\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#tbl0010\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"tbl0010\"><span class=\"anchor-text\">\u88682<\/span><\/a>.<\/p>\n<div id=\"tbl0010\" class=\"tables colsep-0 rowsep-0 frame-topbot\">\n<p id=\"sp0025\"><span class=\"label\">\u88682<\/span>\u3002\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u5236\u5fa1\u3059\u308b\u5929\u7136\u5316\u5408\u7269\u306e\u6982\u8981\u3002<\/p>\n<div class=\"groups\">\n<table>\n<thead>\n<tr class=\"rowsep-1\">\n<th scope=\"col\">\u5929\u7136\u7269<\/th>\n<th scope=\"col\">\u30e2\u30c7\u30eb\/\u75be\u60a3<\/th>\n<th scope=\"col\">\u7a2e<\/th>\n<th scope=\"col\">\u52b9\u679c<\/th>\n<th scope=\"col\">\u53c2\u7167<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<th scope=\"row\">\u30ac\u30b9\u30c8\u30ed\u30c7\u30a3\u30f3<\/th>\n<td>\u4e2d\u5927\u8133\u52d5\u8108\u9589\u585e\/\u518d\u704c\u6d41\uff08MCAO\/R\uff09\u3001\u9178\u7d20-\u30b0\u30eb\u30b3\u30fc\u30b9\u6b20\u4e4f\/\u518d\u9178\u7d20\u5316\uff08OGD\/R\uff09<\/td>\n<td>\u30c9\u30d6\u30cd\u30ba\u30df\u3068\u30c9\u30d6\u30cd\u30ba\u30df\u306e\u7e01\u76ae\u8cea\u30cb\u30e5\u30fc\u30ed\u30f3<\/td>\n<td>NLRP3\u3001\u708e\u75c7\u56e0\u5b50 (IL-1\u03b2\u3001IL-18) \u304a\u3088\u3073\u5207\u65ad\u578b\u30ab\u30b9\u30d1\u30fc\u30bc 1 \u3092\u4e0b\u65b9\u5236\u5fa1\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u6291\u5236\u3057\u307e\u3059\u3002 lncRNA NEAT1\/miR-22\u20133p \u8ef8\u304a\u3088\u3073 lncRNA NEAT1\/miR-22\u20133p \u8ef8\u3092\u5236\u5fa1\u3057\u307e\u3059<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib204\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib204\"><span class=\"anchor-text\">[204]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u30bf\u30f3\u30b7\u30ce\u30f3IIA<\/th>\n<td>OGD\/R<\/td>\n<td>BV2\u7d30\u80de\uff08\u30cf\u30c4\u30ab\u30cd\u30ba\u30df\u7531\u6765\u306e\u30df\u30af\u30ed\u30b0\u30ea\u30a2\uff09<\/td>\n<td>NLRP3 \u708e\u75c7\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306b\u304a\u3051\u308b IL-1\u03b2 \u304a\u3088\u3073 IL-18 \u306e\u767a\u73fe\u3092\u4f4e\u6e1b\u3057\u307e\u3059\u3002<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib205\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib205\"><span class=\"anchor-text\">[205]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u30ec\u30aa\u30cc\u30ea\u30f3<\/th>\n<td>MCAO<\/td>\n<td>\u30c9\u30d6\u30cd\u30ba\u30df<\/td>\n<td>NLRP3\u306e\u767a\u73fe\u3092\u4f4e\u4e0b\u3055\u305b\u308b<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib206\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib206\"><span class=\"anchor-text\">[206]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u30da\u30aa\u30cb\u30d5\u30ed\u30ea\u30f3<\/th>\n<td>MCAO<\/td>\n<td>\u30c9\u30d6\u30cd\u30ba\u30df<\/td>\n<td>NLRP3\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3001IL-1\u03b2\u30ec\u30d9\u30eb\u3092\u963b\u5bb3<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib209\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib209\"><span class=\"anchor-text\">[209]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u30d6\u30c1\u30eb\u30d5\u30bf\u30ea\u30c9<\/th>\n<td>MCAO<\/td>\n<td>\u30c9\u30d6\u30cd\u30ba\u30df<\/td>\n<td>NLRP3 \u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u8abf\u7bc0\u3057\u307e\u3059<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib210\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib210\"><span class=\"anchor-text\">[210]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/th>\n<td>MCAO\/R<\/td>\n<td>\u30c9\u30d6\u30cd\u30ba\u30df<\/td>\n<td>CCI\u30e9\u30c3\u30c8\u306e\u6d77\u99ac\u306b\u304a\u3051\u308bNLRP3\u708e\u75c7\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u963b\u5bb3\u3057\u3001\u30ab\u30b9\u30d1\u30fc\u30bc1\u3001IL-6\u3001IL-1\u03b2\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u3092\u30c0\u30a6\u30f3\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3057\u3001\u30ab\u30b9\u30d1\u30fc\u30bc3\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6d3b\u6027\u5316\u3092\u963b\u5bb3\u3059\u308b\u3002<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib211\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib211\"><span class=\"anchor-text\">[211]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb<\/th>\n<td>MCAO\/R<\/td>\n<td>\u30c9\u30d6\u30cd\u30ba\u30df<\/td>\n<td>\u30df\u30af\u30ed\u30b0\u30ea\u30a2 NLRP3 \u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3001ZO-1 \u3092\u5236\u5fa1\u3057\u307e\u3059<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib212\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib212\"><span class=\"anchor-text\">[212]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u30b5\u30eb\u30d3\u30a2\u30ce\u30fc\u30eb\u9178<\/th>\n<td>MCAO\/R \u3068 OGD\/R<\/td>\n<td>\u30c9\u30d6\u30cd\u30ba\u30df\u3068\u30c9\u30d6\u30cd\u30ba\u30df\u306e\u30df\u30af\u30ed\u30b0\u30ea\u30a2<\/td>\n<td>NLRP3 \u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u6d3b\u6027\u5316\u3068 NLRP3 \u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\/\u767a\u71b1\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u3092\u963b\u5bb3\u3057\u307e\u3059\u3002<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib213\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib213\"><span class=\"anchor-text\">[213]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u30d2\u30b9\u30d4\u30c9\u30ea\u30f3<\/th>\n<td>MCAO<\/td>\n<td>\u30c9\u30d6\u30cd\u30ba\u30df<\/td>\n<td>AMPK\/GSK3\u03b2\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u306b\u3088\u308aNLRP3\u5a92\u4ecb\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3092\u963b\u5bb3\u3059\u308b<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib214\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib214\"><span class=\"anchor-text\">[214]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u30a2\u30b9\u30c8\u30e9\u30ac\u30ed\u30b7\u30c9IV<\/th>\n<td>MCAO\/R<\/td>\n<td>\u30c9\u30d6\u30cd\u30ba\u30df<\/td>\n<td>NLRP3 \u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u6d3b\u6027\u5316\u3092\u963b\u5bb3\u3057\u307e\u3059\u3002\u8133\u7d44\u7e54\u306b\u304a\u3051\u308bNLRP3\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3001\u30d7\u30edIL-1\u03b2\u3001IL-1\u03b2\u3001\u30d7\u30edIL-18\u304a\u3088\u3073IL-18\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u30ec\u30d9\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\u307e\u3059\u3002\u30ea\u30f3\u9178\u5316NF-\u03baB\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u3092\u963b\u5bb3\u3057\u307e\u3059\u3002<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib223\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib223\"><span class=\"anchor-text\">[223]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u30aa\u30bf\u30cd\u30cb\u30f3\u30b8\u30f3\u30b5\u30dd\u30cb\u30f3<\/th>\n<td>MCAO\/R<\/td>\n<td>\u30c9\u30d6\u30cd\u30ba\u30df<\/td>\n<td>PINK1\/\u30d1\u30fc\u30ad\u30f3\u7d4c\u8def\u3092\u5236\u5fa1\u3057\u3001NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u6d3b\u6027\u5316\u3092\u963b\u5bb3\u3059\u308b<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib232\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib232\"><span class=\"anchor-text\">[232]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u6843\u7d05\u56db\u70cf\u714e\u3058\u85ac<\/th>\n<td>MCAO<\/td>\n<td>\u30c9\u30d6\u30cd\u30ba\u30df<\/td>\n<td>DRP1\u3001NLRP3\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3001IL-1\u03b2\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ec\u30d9\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\u308b<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib233\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib233\"><span class=\"anchor-text\">[233]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u6843\u7d05\u56db\u70cf\u714e\u3058\u85ac<\/th>\n<td>MCAO\/R<\/td>\n<td>\u30c9\u30d6\u30cd\u30ba\u30df<\/td>\n<td>HMGB1\/TLR4\/NF-kB\u304a\u3088\u3073MAPK\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u963b\u5bb3\u3057\u307e\u3059<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib234\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib234\"><span class=\"anchor-text\">[234]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u30ca\u30aa\u30b7\u30f3\u30c1\u30f3\u30ab\u30d7\u30bb\u30eb<\/th>\n<td>MCAO\/R<\/td>\n<td>\u30e1\u30ea\u30aa\u30cd\u30b9\u30fb\u30a6\u30f3\u30b0\u30ad\u30e5\u30e9\u30c8\u30a5\u30b9<\/td>\n<td>ASC\u3001NLRP3\u3001\u304a\u3088\u3073\u30ab\u30b9\u30d1\u30fc\u30bc-1 \u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4e0b\u65b9\u5236\u5fa1\u3057\u307e\u3059\u3002 IL-18\u304a\u3088\u3073IL-1\u03b2\u306e\u542b\u6709\u91cf\u3092\u6e1b\u5c11\u3055\u305b\u307e\u3059\u3002<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib239\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib239\"><span class=\"anchor-text\">[239]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u6b66\u967d\u74b0\u6b66\u714e\u3058\u85ac<\/th>\n<td>MCAO\/R<\/td>\n<td>\u30c9\u30d6\u30cd\u30ba\u30df<\/td>\n<td>NLRP3 \u5a92\u4ecb\u6a19\u6e96\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u306e NLRP3\u3001ASC\u3001\u30d7\u30ed\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3001\u304a\u3088\u3073 IL-1\u03b2 \u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u3092\u963b\u5bb3\u3057\u307e\u3059\u3002<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib244\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib244\"><span class=\"anchor-text\">[244]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u9f8d\u829d\u714e\u3058<\/th>\n<td>MCAO\/R<\/td>\n<td>\u30c9\u30d6\u30cd\u30ba\u30df<\/td>\n<td>\u30ab\u30b9\u30d1\u30fc\u30bc-1 \u304a\u3088\u3073 IL-18 \u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u3092\u4e0b\u65b9\u5236\u5fa1\u3057\u307e\u3059<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib245\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib245\"><span class=\"anchor-text\">[245]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u6613\u5947\u706b\u96ea\u51e6\u65b9<\/th>\n<td>MCAO<\/td>\n<td>\u30c9\u30d6\u30cd\u30ba\u30df<\/td>\n<td>IL-1\u03b2\u3001TNF-\u03b1\u3001IL-18\u306e\u30ec\u30d9\u30eb\u3068\u3001P2RX7\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3001\u30ab\u30b9\u30d1\u30fc\u30bc-11\u3001GSMDD\u306e\u76f8\u5bfe\u767a\u73fe\u3092\u4f4e\u4e0b\u3055\u305b\u307e\u3059\u3002<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib247\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib247\"><span class=\"anchor-text\">[247]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u795e\u83dc\u798f\u5143\u714e\u3058\u85ac<\/th>\n<td>OGD<\/td>\n<td>\u30c9\u30d6\u30cd\u30ba\u30df\u7531\u6765\u306ePC12\u7d30\u80de<\/td>\n<td>NLRP3\/\u30ab\u30b9\u30d1\u30fc\u30bc-1\u3092\u963b\u5bb3\u3059\u308b<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib250\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib250\"><span class=\"anchor-text\">[250]<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/section>\n<\/section>\n<section id=\"sec0195\">\n<h2 id=\"sect0215\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">6. \u5c55\u671b<\/h2>\n<p id=\"p0255\">\u79c1\u305f\u3061\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u9577\u5e74\u306b\u308f\u305f\u308a\u3001IS\u5f8c\u306e\u8840\u7ba1\u795e\u7d4c\u5358\u4f4d\u306b\u304a\u3051\u308b\u3055\u307e\u3056\u307e\u306a\u7d30\u80de\u7fa4\uff08\u30cb\u30e5\u30fc\u30ed\u30f3\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3001\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306a\u3069\uff09\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u7d30\u80de\u6b7b\u30e2\u30fc\u30c9\u3092\u7814\u7a76\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u4ed6\u306e\u7814\u7a76\u5831\u544a\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u3068\u3001IS\u5f8c\u306b\u306f\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3001\u30d5\u30a7\u30ed\u30c8\u30fc\u30b7\u30b9\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306a\u3069\u306e\u3055\u307e\u3056\u307e\u306a\u7d30\u80de\u6b7b\u30e2\u30fc\u30c9\u304c\u767a\u751f\u3057\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3068\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u5f62\u614b\u306b\u306f\u4e00\u5b9a\u306e\u985e\u4f3c\u70b9\u304c\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u795e\u7d4c\u708e\u75c7\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroinflammation\">\u795e\u7d4c\u708e\u75c7<\/a>\u00a0IS \u5f8c\u306e\u795e\u7d4c\u708e\u75c7\u306f\u8133\u640d\u50b7\u306b\u3064\u306a\u304c\u308b\u6700\u3082\u91cd\u8981\u306a\u75c5\u7406\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u3067\u3042\u308a\u3001\u305d\u306e\u4e2d\u3067\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306f\u795e\u7d4c\u708e\u75c7\u306e\u91cd\u8981\u306a\u90e8\u5206\u3067\u3059\u3002\u3053\u308c\u306f\u3001\u8133\u865a\u8840\u5f8c\u306e\u795e\u7d4c\u708e\u75c7\u95a2\u9023\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u7d30\u80de\u6b7b\u306b\u304a\u3044\u3066\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u304c\u7570\u5e38\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u95a2\u9023\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306f\u3001\u4ed6\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u7d30\u80de\u6b7b\u7d4c\u8def\u3068\u3082\u4ea4\u5dee\u3057\u3066\u304a\u308a\u3001\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u3092\u6a19\u7684\u3068\u3057\u305f\u85ac\u5264\u958b\u767a\u304c IS \u306e\u6cbb\u7642\u306b\u91cd\u8981\u306a\u65b9\u6cd5\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p id=\"p0260\">\u672c\u7814\u7a76\u3067\u306f\u3001\u307e\u3060\u6539\u5584\u306e\u4f59\u5730\u304c\u3042\u308b\u3002(1)\u672c\u7814\u7a76\u306e\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u6a19\u6e96\u5316\u3068\u7d71\u4e00\u306e\u554f\u984c\u306b\u3088\u308a\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u795e\u7d4c\u7cfb\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nervous-system\">\u795e\u7d4c\u7cfb<\/a>\u00a0\u77db\u76fe\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u5c06\u6765\u306e\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u7814\u7a76\u306b\u306f\u3001\u6297\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u85ac\u306e\u5b9f\u969b\u306e\u52b9\u679c\u3092\u6c7a\u5b9a\u3059\u308b\u3053\u3068\u3082\u3067\u304d\u308b\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u3088\u308a\u6a19\u6e96\u5316\u3055\u308c\u7d71\u4e00\u3055\u308c\u305f\u5b89\u5b9a\u3057\u305f\u30e2\u30c7\u30eb\u304c\u5fc5\u8981\u3067\u3059\u3002 (2) \u4eca\u5f8c\u306e\u7814\u7a76\u3067\u306f\u3001\u5929\u7136\u5316\u5408\u7269\u306e\u9577\u671f\u7684\u306a\u8133\u4fdd\u8b77\u52b9\u679c\u3068\u3001\u3055\u307e\u3056\u307e\u306a\u3052\u3063\u6b6f\u985e\u304a\u3088\u3073\u5927\u578b\u54fa\u4e73\u985e\u306e\u8133\u5352\u4e2d\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u5236\u5fa1\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u691c\u8a3c\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4eca\u5f8c\u306f\u3055\u3089\u306b\u6ce8\u610f\u3092\u6255\u3046\u5fc5\u8981\u304c\u3042\u308b\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u85ac\u7269\u52d5\u614b\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pharmacokinetics\">\u85ac\u7269\u52d5\u614b<\/a>,\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u85ac\u529b\u5b66\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pharmacodynamics\">\u85ac\u529b\u5b66<\/a>\u3001\u304a\u3088\u3073\u73fe\u5728\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u8abf\u7bc0\u3057\u3066\u3044\u308b\u5929\u7136\u5316\u5408\u7269\u306e\u6bd2\u6027\u5b66\u7684\u7279\u6027\u3002 (3) \u3055\u3089\u306b\u3001\u8133\u865a\u8840\u6027\u8133\u5352\u4e2d\u306b\u304a\u3051\u308b\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u5236\u5fa1\u306b\u304a\u3051\u308b\u5929\u7136\u5316\u5408\u7269\u306e\u7d44\u307f\u5408\u308f\u305b\u306e\u76f8\u4e57\u52b9\u679c\u3068\u3001\u795e\u7d4c\u708e\u75c7\u3092\u6291\u5236\u3059\u308b\u795e\u7d4c\u4fdd\u8b77\u52b9\u679c\u306b\u3064\u3044\u3066\u3082\u3001\u5c06\u6765\u7684\u306b\u8abf\u67fb\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002 (4) \u3059\u3079\u3066\u306e\u7d50\u679c\u304c\u826f\u597d\u3067\u3042\u308c\u3070\u3001\u6b21\u306e\u30b9\u30c6\u30c3\u30d7\u306f\u6b21\u306e\u30b9\u30c6\u30c3\u30d7\u3067\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect\u306eAI\u751f\u6210\u30c8\u30d4\u30c3\u30af\u30da\u30fc\u30b8\u304b\u3089\u81e8\u5e8a\u8a66\u9a13\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u8a73\u3057\u304f\u77e5\u308b\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/clinical-trial\">\u81e8\u5e8a\u8a66\u9a13<\/a>\u00a0\u6f5c\u5728\u80fd\u529b\u306e\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u690d\u7269\u5316\u5b66\u7269\u8cea\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/phytochemical\">\u690d\u7269\u5316\u5b66\u7269\u8cea<\/a>\u00a0\u8133\u865a\u8840\/\u8133\u5352\u4e2d\u306b\u5bfe\u3059\u308b\u795e\u7d4c\u4fdd\u8b77\u52b9\u679c\u3092\u8abf\u67fb\u3059\u308b\u305f\u3081\u3067\u3059\uff08\u305f\u3068\u3048\u3070\u3001\u30c1\u30fc\u30e0\u306f\u73fe\u5728\u3001\u8133\u5c0f\u8840\u7ba1\u75be\u60a3\u306e\u6cbb\u7642\u306b\u304a\u3051\u308bNaotai Fang\u306e\u81e8\u5e8a\u8a66\u9a13\u3092\u5b9f\u65bd\u4e2d\u3067\u3059: ChiCTR1900024524\uff09\u3002<\/p>\n<\/section>\n<section id=\"sec0200\">\n<h2 id=\"sect0220\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">7. \u307e\u3068\u3081<\/h2>\n<p id=\"p0265\">\u708e\u75c7\u8a98\u767a\u6027\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u7d30\u80de\u6b7b\u3067\u3042\u308b\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306f\u3001\u4e3b\u306b\u30ab\u30b9\u30d1\u30fc\u30bc1\u3092\u4ecb\u3057\u305f\u53e4\u5178\u7684\u306a\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u3092\u4ecb\u3057\u3066\u7d30\u80de\u6b7b\u3068\u795e\u7d4c\u708e\u75c7\u3092\u8a98\u767a\u3057\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u75c5\u7406\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3002\u975e\u6a19\u6e96\u7684\u306a\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u3068IS\u306e\u95a2\u4fc2\u306f\u307e\u3060\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u3002\u30d4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9\u306e\u4ed6\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u306f\u3001\u4eca\u5f8c\u3055\u3089\u306b\u7814\u7a76\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u73fe\u5728\u3001\u7814\u7a76\u3067\u306f\u3001\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u85ac\u7269\u30bf\u30fc\u30b2\u30c6\u30a3\u30f3\u30b0\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3076\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/drug-delivery-system\">\u85ac\u7269\u6a19\u7684<\/a>\u00a0\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u7d4c\u8def\u306e\u4e3b\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u865a\u8840\u6027\u8133\u640d\u50b7\u3092\u3042\u308b\u7a0b\u5ea6\u7de9\u548c\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u304c\u3001\u305d\u306e\u7814\u7a76\u306f\u4e3b\u306b\u7d30\u80de\u5b9f\u9a13\u3068\u52d5\u7269\u5b9f\u9a13\u306b\u9650\u5b9a\u3055\u308c\u3066\u304a\u308a\u3001\u7814\u7a76\u306f\u4e0d\u8db3\u3057\u3066\u3044\u307e\u3059\u3002\u00a0<a class=\"topic-link\" title=\"ScienceDirect \u306e AI \u751f\u6210\u30c8\u30d4\u30c3\u30af \u30da\u30fc\u30b8\u304b\u3089\u81e8\u5e8a\u7814\u7a76\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u5b66\u3073\u307e\u3057\u3087\u3046\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/clinical-research\">\u81e8\u5e8a\u7814\u7a76<\/a>\u00a0\u8a3c\u62e0\u3002\u3057\u305f\u304c\u3063\u3066\u3001IS\u306b\u304a\u3051\u308b\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u5236\u5fa1\u6a5f\u69cb\u3092\u63a2\u6c42\u3059\u308b\u3055\u3089\u306a\u308b\u81e8\u5e8a\u7814\u7a76\u306b\u3088\u308a\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u3092\u4e88\u9632\u304a\u3088\u3073\u6cbb\u7642\u3059\u308b\u305f\u3081\u306e\u65b0\u3057\u3044\u6cbb\u7642\u6226\u7565\u3068\u7406\u8ad6\u7684\u57fa\u790e\u304c\u63d0\u4f9b\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u308b\u3002\u5929\u7136\u5316\u5408\u7269\u306b\u3088\u308b\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u5236\u5fa1\u306b\u95a2\u3057\u3066\u3001\u6211\u3005\u306e\u4e00\u822c\u5316\u3092\u901a\u3058\u3066\u3001\u5929\u7136\u690d\u7269\u5316\u5408\u7269\u306f\u5358\u4e00\u6210\u5206\u3060\u3051\u3067\u306a\u304f\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u8133\u865a\u8840\u3092\u5236\u5fa1\u3067\u304d\u308b\u3053\u3068\u304c\u5206\u304b\u308b\u3002\u591a\u6210\u5206\u306e\u5929\u7136\u690d\u7269\u5316\u5408\u7269\u306f\u3001\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u708e\u75c7\u30ab\u30b9\u30b1\u30fc\u30c9\u306e\u8abf\u7bc0\u306b\u304a\u3044\u3066\u6f5c\u5728\u7684\u306a\u76f8\u4e57\u52b9\u679c\u3092\u793a\u3059\u3053\u3068\u3082\u308f\u304b\u308a\u307e\u3059\u3002\u3053\u306e\u3053\u3068\u306f\u3001\u5c06\u6765\u3001\u3055\u307e\u3056\u307e\u306a\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u5a92\u4ecb\u795e\u7d4c\u708e\u75c7\u306b\u5bfe\u3059\u308b\u3055\u307e\u3056\u307e\u306a\u5929\u7136\u5316\u5408\u7269\u306e\u5236\u5fa1\u52b9\u679c\u3092\u7814\u7a76\u3059\u308b\u3053\u3068\u3078\u306e\u52d5\u6a5f\u4ed8\u3051\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n<\/section>\n<section id=\"sec0205\">\n<h2 id=\"sect0225\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">CRediT \u8457\u4f5c\u8005\u8ca2\u732e\u58f0\u660e<\/h2>\n<p id=\"p0270\"><strong>\u30e4\u30f3\u30fb\u30ab\u30a4\u30ea\u30f3\uff1a<\/strong>\u00a0\u6982\u5ff5\u5316\u3001\u65b9\u6cd5\u8ad6\u3001\u5f62\u5f0f\u7684\u5206\u6790\u3001\u8abf\u67fb\u3001\u57f7\u7b46 - \u539f\u6848\u3002\u00a0<strong>\u66fe\u6d41\u4ead\uff1a<\/strong>\u00a0\u6982\u5ff5\u5316\u3001\u65b9\u6cd5\u8ad6\u3001\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3001\u5f62\u5f0f\u5206\u6790\u3001\u8abf\u67fb\u3001\u539f\u7a3f\u57f7\u7b46\u3002\u00a0<strong>\u30b8\u30f3\u30bd\u30f3\u30fb\u30bc\u30f3\uff1a<\/strong>\u00a0\u65b9\u6cd5\u8ad6\u3001\u5f62\u5f0f\u5206\u6790\u3001\u8abf\u67fb;\u00a0<strong>\u30c6\u30a3\u30f3\u30c6\u30a3\u30f3\u30fb\u30d0\u30aa\uff1a<\/strong>\u00a0\u65b9\u6cd5\u8ad6\u3001\u5f62\u5f0f\u7684\u5206\u6790\u3001\u8abf\u67fb\u3001\u57f7\u7b46 - \u539f\u6848\u3002\u00a0<strong>\u30b7\u30e3\u30aa\u30e6\u30a2\u30f3\uff1a<\/strong>\u00a0\u65b9\u6cd5\u8ad6\u3001\u5f62\u5f0f\u5206\u6790\u3001\u8abf\u67fb;\u00a0<strong>\u30b7\u30e3\u30f3\u30b7\u30e3\u30f3\u30fb\u30ef\u30f3\uff1a<\/strong>\u00a0\u65b9\u6cd5\u8ad6\u3001\u5f62\u5f0f\u5206\u6790\u3001\u8abf\u67fb;\u00a0<strong>\u738b\u7fd4\uff1a<\/strong>\u00a0\u65b9\u6cd5\u8ad6\u3001\u5f62\u5f0f\u5206\u6790\u3001\u8abf\u67fb;\u00a0<strong>\u5f90\u660a\uff1a<\/strong>\u00a0\u65b9\u6cd5\u8ad6\u3001\u5f62\u5f0f\u5206\u6790\u3001\u8abf\u67fb;\u00a0<strong>\u30b8\u30f3\u30a6\u30a7\u30f3\u30fb\u30b2\u30fc:<\/strong>\u00a0\u6982\u5ff5\u5316\u3001\u65b9\u6cd5\u8ad6\u3001\u5f62\u5f0f\u5206\u6790\u3001\u8abf\u67fb\u3001\u57f7\u7b46 - \u30ec\u30d3\u30e5\u30fc\u3068\u7de8\u96c6\u3002<\/p>\n<\/section>\n<\/div>\n<section id=\"coi0005\">\n<h2 id=\"sect0230\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">\u5229\u76ca\u76f8\u53cd\u306b\u95a2\u3059\u308b\u58f0\u660e<\/h2>\n<p id=\"p0275\">\u8457\u8005\u3089\u306f\u3001\u672c\u8ad6\u6587\u3067\u5831\u544a\u3055\u308c\u305f\u7814\u7a76\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u306e\u3042\u308b\u3001\u7af6\u5408\u3059\u308b\u91d1\u92ad\u7684\u5229\u76ca\u3084\u500b\u4eba\u7684\u306a\u95a2\u4fc2\u306f\u5b58\u5728\u3057\u306a\u3044\u3053\u3068\u3092\u5ba3\u8a00\u3057\u307e\u3059\u3002<\/p>\n<\/section>\n<section id=\"ack0005\">\n<h2 id=\"sect0235\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">\u8b1d\u8f9e<\/h2>\n<p id=\"p0280\">\u3053\u306e\u4f5c\u54c1\u306f\u3001\u00a0<span id=\"gs1\">\u4e2d\u56fd\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u8ca1\u56e3<\/span>\u00a0(<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs1\"><span class=\"anchor-text\">81774174<\/span><\/a>)\u3001\u00a0<span id=\"gs2\">\u4e2d\u56fd\u306e\u56fd\u5bb6\u91cd\u70b9\u7814\u7a76\u958b\u767a\u30d7\u30ed\u30b8\u30a7\u30af\u30c8<\/span>\u00a0\uff08\u3044\u3044\u3048\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs2\"><span class=\"anchor-text\">2018YFC1704904<\/span><\/a>),\u00a0<span id=\"gs3\">\u6e56\u5357\u7701\u56fd\u7acb\u81ea\u7136\u79d1\u5b66\u57fa\u91d1<\/span>\u3001 \u4e2d\u56fd \uff08<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs3\"><span class=\"anchor-text\">2020JJ5424<\/span><\/a>\u00a0\u305d\u3057\u3066\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs3\"><span class=\"anchor-text\">2020JJ5442<\/span><\/a>),\u00a0<span id=\"gs4\">\u6e56\u5357\u4e2d\u533b\u85ac\u5927\u5b66\u300c\u30c0\u30d6\u30eb\u4e00\u6d41\u300d\u4e2d\u897f\u533b\u5b66\u878d\u5408\u5c02\u653b\u30aa\u30fc\u30d7\u30f3\u57fa\u91d1\u30d7\u30ed\u30b8\u30a7\u30af\u30c8<\/span>\u00a0(<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs4\"><span class=\"anchor-text\">2020ZXYJH08<\/span><\/a>\u00a0\u305d\u3057\u3066\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs4\"><span class=\"anchor-text\">2020ZXYJH09<\/span><\/a>),\u00a0<span id=\"gs5\">\u6e56\u5357\u7701\u6559\u80b2\u5c40\u9752\u5c11\u5e74\u57fa\u91d1\u30d7\u30ed\u30b8\u30a7\u30af\u30c8<\/span>\u00a0(<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs5\"><span class=\"anchor-text\">21B0386<\/span><\/a>).<\/p>\n<\/section>\n<\/div>\n<div class=\"text-content u-font-serif\">\n<section id=\"da0005\">\n<h2 id=\"sect0020\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">\u30c7\u30fc\u30bf\u3068\u8cc7\u6599\u306e\u5165\u624b\u53ef\u80fd\u6027<\/h2>\n<p id=\"p0020\">\u3053\u306e\u7814\u7a76\u306e\u7d50\u679c\u3092\u88cf\u4ed8\u3051\u308b\u305f\u3081\u306b\u4f7f\u7528\u3055\u308c\u305f\u30c7\u30fc\u30bf\u306f\u8a18\u4e8b\u5185\u306b\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/section>\n<\/div>\n<div class=\"Tail text-s\"><\/div>\n<section id=\"bibliog0005\" class=\"bibliography u-font-serif text-s\">\n<h2 class=\"section-title u-h4 u-margin-l-top u-margin-xs-bottom\">\u53c2\u8003\u6587\u732e<\/h2>\n<section id=\"bb0005\" class=\"bibliography-sec\">\n<ol id=\"reference-links-bb0005\" class=\"references\">\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib1\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib1\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[1]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">LE \u30a8\u30f4\u30a1\u30f3\u30b9\u3001JL \u30c6\u30a4\u30e9\u30fc\u3001CJ \u30b9\u30df\u30b9\u3001HAT \u30d7\u30ea\u30c1\u30e3\u30fc\u30c9\u3001AS \u30b0\u30ea\u30fc\u30f3\u30b9\u30bf\u30a4\u30f3\u3001SM \u30a2\u30e9\u30f3<\/div>\n<div id=\"ref-id-sbref1\" class=\"title text-m\">\u5fc3\u8840\u7ba1\u5408\u4f75\u75c7\u3001\u708e\u75c7\u3001\u8133\u5c0f\u8840\u7ba1\u75be\u60a3<\/div>\n<\/div>\n<div class=\"host u-font-sans\">\u5fc3\u81d3\u8840\u7ba1\u7814\u7a76\u3001117 (13) (2021)\u3001pp. 2575-2588\u3001\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1093\/cvr\/cvab284\" target=\"_blank\" rel=\"noreferrer noopener\"><span 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class=\"text\">\u8a18\u4e8b\u3092\u898b\u308b<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85032976954&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref2\"><span class=\"anchor-text\">Scopus\u3067\u898b\u308b<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Clinical%20Evidence%20of%20Exercise%20Benefits%20for%20Stroke&amp;publication_year=2017&amp;author=P.%20Han&amp;author=W.%20Zhang&amp;author=L.%20Kang&amp;author=Y.%20Ma&amp;author=L.%20Fu&amp;author=L.%20Jia&amp;author=H.%20Yu&amp;author=X.%20Chen&amp;author=L.%20Hou&amp;author=L.%20Wang&amp;author=X.%20Yu&amp;author=M.%20Kohzuki&amp;author=Q.%20Guo\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref2\"><span class=\"anchor-text\">Google 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Prim.\u30018 (1) (2022)\u3001p. 12\u3001\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1038\/s41572-022-00337-x\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1038\/s41572-022-00337-x<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">\u8a18\u4e8b\u3092\u898b\u308b<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85125345650&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref4\"><span class=\"anchor-text\">Scopus\u3067\u898b\u308b<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Childhood%20stroke&amp;publication_year=2022&amp;author=P.B.%20Sporns&amp;author=H.J.%20Fullerton&amp;author=S.%20Lee&amp;author=H.%20Kim&amp;author=W.D.%20Lo&amp;author=M.T.%20Mackay&amp;author=M.%20Wildgruber\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref4\"><span class=\"anchor-text\">Google \u30b9\u30ab\u30e9\u30fc<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib5\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib5\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[5]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">MY Wu\u3001GT Yiang\u3001WT Liao\u3001AP Tsai\u3001YL Cheng\u3001PW Cheng\u3001CY Li\u3001CJ Li<\/div>\n<div id=\"ref-id-sbref5\" class=\"title text-m\">\u865a\u8840\u304a\u3088\u3073\u518d\u704c\u6d41\u50b7\u5bb3\u306b\u304a\u3051\u308b\u73fe\u5728\u306e\u6a5f\u69cb\u6982\u5ff5<\/div>\n<\/div>\n<div class=\"host u-font-sans\">\u7d30\u80de\u751f\u7406\u751f\u5316\u5b66\u300146 (4) (2018)\u3001pp. 1650-1667\u3001\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1159\/000489241\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1159\/000489241<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">PDF\u3092\u898b\u308b<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">\u3053\u306e\u8a18\u4e8b\u306f\u7121\u6599\u3067\u3054\u89a7\u3044\u305f\u3060\u3051\u307e\u3059\u3002<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" 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href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Targeting%20Ferroptosis%3A%20Pathological%20Mechanism%20and%20Treatment%20of%20Ischemia-Reperfusion%20Injury&amp;publication_year=2021&amp;author=X.%20Li&amp;author=N.%20Ma&amp;author=J.%20Xu&amp;author=Y.%20Zhang&amp;author=P.%20Yang&amp;author=X.%20Su&amp;author=Y.%20Xing&amp;author=N.%20An&amp;author=F.%20Yang&amp;author=G.%20Zhang&amp;author=L.%20Zhang&amp;author=Y.%20Xing\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref11\"><span class=\"anchor-text\">Google \u30b9\u30ab\u30e9\u30fc<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib12\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib12\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[12]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div 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Bernassola\u3001MJM Bertrand\u3001K. Bianchi\u3001MV Blagosklonny\u3001K. Blomgren\u3001C. Borner\u3001P. Boya\u3001C. Brenner\u3001M. Campanella\u3001E. Candi\u3001D. Carmona-\u30b0\u30c6\u30a3\u30a8\u30ec\u30b9\u3001F. \u30c1\u30a7\u30c3\u30b3\u30fc\u30cb\u3001FK \u30c1\u30e3\u30f3\u3001NS \u30b7\u30e3\u30f3\u30c7\u30eb\u3001EH \u30c1\u30a7\u30f3\u3001JE \u30c1\u30d7\u30af\u3001JA \u30b7\u30c9\u30ed\u30d5\u30b9\u30ad\u30fc\u3001A. \u30c1\u30a7\u30c1\u30e3\u30ce\u30fc\u30d5\u30a1\u30fc\u3001GM \u30b3\u30fc\u30a8\u30f3\u3001M. \u30b3\u30f3\u30e9\u30c3\u30c9\u3001JR \u30af\u30d3\u30b8\u30e7\u30b9 \u30eb\u30a4\u30b9\u3001PE \u30c1\u30e3\u30dc\u30bf\u30eb\u3001V. \u30c0\u30f3\u30b8\u30e7\u30ec\u30e9\u3001TM \u30c9\u30fc\u30bd\u30f3\u3001VL\u30c9\u30fc\u30bd\u30f3\u3001V. \u30c7\u30fb\u30ed\u30fc\u30ec\u30f3\u30c4\u30a3\u3001R. \u30c7\u30fb\u30de\u30ea\u30a2\u3001KM \u30c7\u30d0\u30c6\u30a3\u30f3\u3001RJ \u30c7\u30d9\u30e9\u30eb\u30c7\u30a3\u30cb\u30b9\u3001M. \u30c7\u30b7\u30e5\u30e0\u30af\u3001N. \u30c7\u30a3\u30fb\u30c0\u30cb\u30a8\u30ec\u3001F. \u30c7\u30a3\u30fb\u30f4\u30a3\u30eb\u30b8\u30ea\u30aa\u3001VM \u30c7\u30a3\u30af\u30b7\u30c3\u30c8\u3001SJ \u30c7\u30a3\u30af\u30bd\u30f3\u3001CS \u30c0\u30b1\u30c3\u30c8\u3001BD \u30c7\u30a3\u30f3\u30e9\u30cf\u30c8\u3001WS \u30a8\u30eb\u30fb\u30c7\u30a4\u30ea\u30fc\u3001JW\u30a8\u30eb\u30ed\u30c3\u30c9\u3001GM \u30d5\u30a3\u30df\u30a2\u3001S. \u30d5\u30eb\u30c0\u3001AJ \u30ac\u30eb\u30b7\u30a2\uff1d\u30b5\u30a8\u30b9\u3001AD \u30ac\u30fc\u30b0\u3001C. \u30ac\u30ea\u30c9\u3001E. \u30ac\u30d0\u30c1\u30aa\u30c6\u30a3\u30b9\u3001P. \u30b4\u30eb\u30b9\u30bf\u30a4\u30f3\u3001E. \u30b4\u30c3\u30c8\u30ea\u30fc\u30d6\u3001DR \u30b0\u30ea\u30fc\u30f3\u3001LA \u30b0\u30ea\u30fc\u30f3\u3001H. \u30b0\u30ed\u30fc\u30cd\u30de\u30a4\u30e4\u30fc\u3001A. \u30b0\u30ed\u30b9\u3001G. \u30cf\u30a4\u30ce\u30c4\u30ad\u30fc\u3001JM \u30cf\u30fc\u30c9\u30a6\u30a3\u30c3\u30af\u3001IS \u30cf\u30ea\u30b9\u3001MO \u30d8\u30f3\u30ac\u30eb\u30c8\u30ca\u30fc\u3001C. \u30d8\u30c3\u30c4\u3001H. \u4e00\u6761\u3001M. \u30e4\u30c3\u30c6\u30e9\u3001B. \u30b8\u30e7\u30bc\u30d5\u3001PJ \u30b8\u30e7\u30b9\u30c8\u3001PP \u30b8\u30e5\u30a4\u30f3\u3001WJ \u30ab\u30a4\u30b6\u30fc\u3001M. \u30ab\u30ea\u30f3\u3001T. \u30ab\u30a6\u30d5\u30de\u30f3\u3001O. \u30b1\u30c3\u30d7\u3001A. \u30ad\u30e0\u30c1\u3001RN \u30ad\u30c3\u30c4\u30a3\u30b9\u3001DJ \u30af\u30ea\u30aa\u30f3\u30b9\u30ad\u30fc\u3001RA \u30ca\u30a4\u30c8\u3001S. \u30af\u30de\u30fc\u30eb\u3001SW \u30ea\u30fc\u3001JJ \u30eb\u30de\u30b9\u30bf\u30fc\u30ba\u3001B. \u30ec\u30d0\u30a4\u30f3\u3001A. \u30ea\u30f3\u30ab\u30fc\u30de\u30f3\u3001SA \u30ea\u30d7\u30c8\u30f3\u3001RA \u30ed\u30c3\u30af\u30b7\u30f3\u3001C. \u30ed\u30da\u30b9\uff1d\u30aa\u30fc\u30c6\u30a3\u30f3\u3001SW \u30ed\u30a6\u3001T. \u30ea\u30e5\u30fc\u30c7\u3001E. \u30eb\u30b0\u30ea\u3001M. \u30de\u30af\u30d5\u30a1\u30fc\u30ec\u30f3\u3001F. \u30de\u30c7\u30aa\u3001M. \u30de\u30ec\u30f4\u30a3\u30c3\u30c4\u3001W. \u30de\u30ed\u30eb\u30cb\u3001G. \u30de\u30cb\u30c3\u30af\u3001JC \u30de\u30ea\u30f3\u3001SJ \u30de\u30fc\u30c6\u30a3\u30f3\u3001JC \u30de\u30eb\u30c6\u30a3\u30cc\u30fc\u3001JP \u30e1\u30c7\u30de\u3001P. \u30e1\u30fc\u30ec\u30f3\u3001P. \u30de\u30a4\u30e4\u30fc\u3001S. \u30e1\u30ea\u30ce\u3001EA \u30df\u30e3\u30aa\u3001JD \u30e2\u30eb\u30b1\u30f3\u30c6\u30a3\u30f3\u3001UM \u30e2\u30fc\u30eb\u3001C. \u30e0\u30cb\u30e7\u30b9 \u30d4\u30cd\u30c9\u3001S. \u6c38\u7530\u3001G. \u30cc\u30cb\u30a7\u30b9\u3001A. \u30aa\u30d9\u30eb\u30b9\u30c8\u3001M. \u30aa\u30fc\u30ec\u30f3\u3001M. \u30aa\u30fc\u30d0\u30fc\u30db\u30eb\u30c4\u30a1\u30fc\u3001M. \u30d1\u30ac\u30fc\u30ce\u3001T. \u30d1\u30ca\u30ec\u30bf\u30ad\u30b9\u3001M. \u30d1\u30b9\u30d1\u30e9\u30ad\u30b9\u3001JM \u30da\u30cb\u30f3\u30b8\u30e3\u30fc\u3001DM \u30da\u30ec\u30a4\u30e9\u3001S. Pervaiz\u3001ME Peter\u3001M. Piacentini\u3001P. Pinton\u3001JHM Prehn\u3001H. Puthalakath\u3001GA Rabinovich\u3001M. Rehm\u3001R. Rizzuto\u3001CMP Rodrigues\u3001DC Rubinsztein\u3001T. Rudel\u3001KM Ryan\u3001E. Sayan\u3001L. Scorrano\u3001F. Shao\u3001Y. Shi\u3001J. Silke\u3001HU Simon\u3001A. Sistigu\u3001BR Stockwell\u3001A. Strasser\u3001G. Szabadkai\u3001SWG Tait\u3001D. Tang\u3001N. Tavernarakis\u3001A. Thorburn\u3001Y. \u8fbb\u672c\u3001B. \u30bf\u30fc\u30af\u3001T. \u30f4\u30a1\u30f3\u30c7\u30f3 \u30d9\u30eb\u30b2\u3001P. \u30f4\u30a1\u30f3\u30c7\u30ca\u30d9\u30fc\u30ec\u3001MG \u30f4\u30a1\u30f3\u30c0\u30fc \u30cf\u30a4\u30c7\u30f3\u3001A. \u30f4\u30a3\u30eb\u30f3\u30ac\u30fc\u3001HW \u30f4\u30a1\u30fc\u30b8\u30f3\u3001KH \u30f4\u30fc\u30c7\u30f3\u3001D. \u30f4\u30c1\u30c3\u30c1\u3001EF \u30ef\u30fc\u30b0\u30ca\u30fc\u3001H. \u30f4\u30a1\u30eb\u30c1\u30e3\u30c3\u30af\u3001D. \u30a6\u30a9\u30e9\u30c3\u30af\u3001Y. \u30ef\u30f3\u3001JA \u30a6\u30a7\u30eb\u30ba\u3001 W. \u30a6\u30c3\u30c9\u3001J. \u30e6\u30a2\u30f3\u3001Z. \u30b6\u30b1\u30ea\u3001B. \u30b8\u30f4\u30a9\u30c8\u30d5\u30b9\u30ad\u30fc\u3001L. \u30b8\u30c3\u30c8\u30d5\u30a9\u30fc\u30b2\u30eb\u3001G. \u30e1\u30ea\u30ce\u3001G. \u30af\u30ec\u30fc\u30de\u30fc<\/div>\n<div id=\"ref-id-sbref92\" class=\"title text-m\">\u7d30\u80de\u6b7b\u306e\u5206\u5b50\u6a5f\u69cb: 2018 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href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85036533976&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref92\"><span class=\"anchor-text\">Scopus\u3067\u898b\u308b<\/span><\/a><a class=\"anchor link anchor-default\" 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link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-84954236024&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref137\"><span class=\"anchor-text\">Scopus\u3067\u898b\u308b<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Protection%20of%20the%20brain%20following%20cerebral%20ischemia%20through%20the%20attenuation%20of%20PARP-1-induced%20neurovascular%20unit%20damage%20in%20rats&amp;publication_year=2015&amp;author=R.%20Zhang&amp;author=S.%20Tang&amp;author=W.%20Huang\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref137\"><span class=\"anchor-text\">Google \u30b9\u30ab\u30e9\u30fc<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib139\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib139\" 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class=\"message\">\u3053\u306e\u8a18\u4e8b\u306f\u7121\u6599\u3067\u3054\u89a7\u3044\u305f\u3060\u3051\u307e\u3059\u3002<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85067036552&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref139\"><span class=\"anchor-text\">Scopus\u3067\u898b\u308b<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=NLRP3%20inflammasome%20as%20a%20potential%20treatment%20in%20ischemic%20stroke%20concomitant%20with%20diabetes&amp;publication_year=2019&amp;author=P.%20Hong&amp;author=R.N.%20Gu&amp;author=F.X.%20Li\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref139\"><span class=\"anchor-text\">Google \u30b9\u30ab\u30e9\u30fc<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib141\" class=\"anchor 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href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85092632738&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref158\"><span class=\"anchor-text\">Scopus\u3067\u898b\u308b<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=CD137%20Ligand-CD137%20interaction%20is%20required%20for%20inflammasome-associated%20brain%20injury%20following%20ischemic%20stroke&amp;publication_year=2020&amp;author=D.Y.%20Fann&amp;author=E.P.%20Nickles&amp;author=L.%20Poh&amp;author=V.%20Rajeev&amp;author=S.%20Selvaraji&amp;author=H.%20Schwarz&amp;author=T.V.%20Arumugam\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref158\"><span class=\"anchor-text\">Google \u30b9\u30ab\u30e9\u30fc<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib160\" class=\"anchor anchor-default\" 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Yu<\/div>\n<div id=\"ref-id-sbref165\" class=\"title text-m\">\u9577\u3044\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA MEG3\u306fmiR-485\/AIM2\u8ef8\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3067\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u5897\u52a0\u3055\u305b\u3001\u8133\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u3092\u4fc3\u9032\u3059\u308b<\/div>\n<\/div>\n<div class=\"host u-font-sans\">\u7d4c\u9a13\u5024Neurol.\u3001325 (2020)\u3001\u8a18\u4e8b 113139\u3001\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.expneurol.2019.113139\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.expneurol.2019.113139<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014488619302869\/pdfft?md5=c32009110f4a234e536f16bbd938c229&amp;pid=1-s2.0-S0014488619302869-main.pdf\" target=\"_blank\" 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text-m\">\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306e\u751f\u7406\u75c5\u7406\u5b66\uff1a\u7d30\u80de\u9593\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3001\u708e\u75c7\u3001\u7d30\u80de\u6b7b\u306e\u4ea4\u5dee\u70b9<\/div>\n<\/div>\n<div class=\"comment\">2015<\/div>\n<div class=\"host u-font-sans\">\u30d7\u30ed\u30b0\u30ec\u3002 Neurobiol.\u3001130 (2015)\u3001pp. 86-120<\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0301008215000374\/pdfft?md5=1559dfe9f57d972ab95684120a559165&amp;pid=1-s2.0-S0301008215000374-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref166\"><span class=\"anchor-text\">PDF\u3092\u898b\u308b<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0301008215000374\" aria-describedby=\"ref-id-sbref166\"><span 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text-m\">\u8133\u865a\u8840\u306b\u5bfe\u3059\u308b\u67ff\u306e\u8449\u6709\u52b9\u6210\u5206\u3068\u76f4\u5fc3\u6e05\u9320\u306e\u795e\u7d4c\u4fdd\u8b77\u52b9\u679c\u306b\u95a2\u3059\u308b\u7814\u7a76[D]<\/div>\n<\/div>\n<div class=\"host u-font-sans\">\u4e2d\u5c71\u5927\u5b66\u3001\u5e83\u5dde (2004)<\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Study%20on%20the%20neuroprotective%20effect%20of%20persimmon%20leaf%20active%20ingredients%20and%20Naoxinqing%20tablet%20on%20cerebral%20ischemia%20D&amp;publication_year=2004&amp;author=Bei%20Weijian\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref237\"><span class=\"anchor-text\">Google \u30b9\u30ab\u30e9\u30fc<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib239\" class=\"anchor anchor-default\" 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class=\"anchor-text\">Google \u30b9\u30ab\u30e9\u30fc<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib257\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib257\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[257]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">SA \u30bf\u30cc\u30bb\u30d7\u30c6\u30ed\u3001MT \u30ea\u30f3\u3001SL \u30a4\u30a7\u3001CL \u30a4\u30a7<\/div>\n<div id=\"ref-id-sbref256\" class=\"title text-m\">\u9759\u8108\u5185\u30a2\u30eb\u30ae\u30cb\u30f3\u6295\u4e0e\u306fNLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u6d3b\u6027\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u591a\u83cc\u6027\u6557\u8840\u75c7\u306e\u30de\u30a6\u30b9\u306b\u304a\u3051\u308b\u6025\u6027\u814e\u969c\u5bb3\u3092\u8efd\u6e1b\u3059\u308b<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Mediat. Inflamm., 2020 (2020), \u8a18\u4e8b3201635,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1155\/2020\/3201635\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1155\/2020\/3201635<\/span><\/a><\/div>\n<div class=\"comment\">PMID: 32454788; PMCID: PMC7238342\u3002<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">\u8a18\u4e8b\u3092\u898b\u308b<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85085510204&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref256\"><span class=\"anchor-text\">Scopus\u3067\u898b\u308b<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Intravenous%20Arginine%20Administration%20Downregulates%20NLRP3%20inflammasome%20activity%20and%20attenuates%20acute%20kidney%20injury%20in%20mice%20with%20polymicrobial%20sepsis&amp;publication_year=2020&amp;author=S.A.%20Tanuseputero&amp;author=M.T.%20Lin&amp;author=S.L.%20Yeh&amp;author=C.L.%20Yeh\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref256\"><span class=\"anchor-text\">Google \u30b9\u30ab\u30e9\u30fc<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<\/ol>\n<\/section>\n<\/section>\n<div id=\"section-cited-by\">\n<section class=\"ListArticles preview\" aria-label=\"\u306b\u3088\u3063\u3066\u5f15\u7528\">\n<div class=\"PageDivider\"><\/div>\n<header id=\"citing-articles-header\">\n<h2 class=\"u-h4 u-margin-l-ver u-font-serif\">\u5f15\u7528\u5143 (7)<\/h2>\n<\/header>\n<div aria-describedby=\"citing-articles-header\">\n<div class=\"citing-articles u-margin-l-bottom\">\n<ul>\n<li class=\"ListArticleItem u-margin-l-bottom\">\n<div class=\"sub-heading u-margin-xs-bottom\">\n<p id=\"citing-articles-article-0-title\" class=\"u-font-serif\"><a class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874123009492\"><span class=\"anchor-text\">\u30ab\u30a4\u30b3\u30d0\u30c8\u30ea\u30c1\u30ab\u30c8\u30a5\u30b9\u62bd\u51fa\u7269\u306f\u51dd\u56fa\u56e0\u5b50\u216b\u3092\u6d3b\u6027\u5316\u3057\u3001\u8133\u865a\u8840\/\u518d\u704c\u6d41\u640d\u50b7\u3092\u60a3\u3063\u305f\u30e9\u30c3\u30c8\u306e\u8840\u7ba1\u65b0\u751f\u3092\u4fc3\u9032\u3057\u307e\u3059<\/span><\/a><\/p>\n<div class=\"text-s\">2024\u5e74\u3001\u6c11\u65cf\u85ac\u7406\u5b66\u30b8\u30e3\u30fc\u30ca\u30eb<\/div>\n<\/div>\n<div class=\"buttons text-s\">\n<p>&nbsp;<\/p>\n<\/div>\n<\/li>\n<li class=\"ListArticleItem u-margin-l-bottom\">\n<div class=\"sub-heading u-margin-xs-bottom\">\n<p id=\"citing-articles-article-1-title\" class=\"u-font-serif\"><a class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874123008589\"><span class=\"anchor-text\">\u8133\u865a\u8840\u30fb\u518d\u6f45\u6d41\u5f8c\u306e\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u306b\u5bfe\u3059\u308b\u30b8\u30a8\u30c9\u30a5\u30d5\u30aa\u30b7\u30e5\u30a8\u714e\u3058\u85ac\u306e\u795e\u7d4c\u4fdd\u8b77\u52b9\u679c\u2014\u30b0\u30ea\u30a2\u8840\u7ba1\u5358\u4f4d\u306e\u89b3\u70b9\u304b\u3089<\/span><\/a><\/p>\n<div class=\"text-s\">2024\u5e74\u3001\u6c11\u65cf\u85ac\u7406\u5b66\u30b8\u30e3\u30fc\u30ca\u30eb<\/div>\n<\/div>\n<div class=\"buttons text-s\">\n<p>&nbsp;<\/p>\n<\/div>\n<\/li>\n<li class=\"ListArticleItem u-margin-l-bottom\">\n<div class=\"sub-heading u-margin-xs-bottom\">\n<p id=\"citing-articles-article-2-title\" class=\"u-font-serif\"><a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.21203\/rs.3.rs-3691555\/v1\" target=\"_blank\" rel=\"noopener\"><span class=\"anchor-text\">\u865a\u8840\u6027\u8133\u5352\u4e2d\u306b\u304a\u3051\u308b\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u95a2\u9023\u306e\u5dee\u6b21\u7684\u306b\u767a\u73fe\u3055\u308c\u305f\u907a\u4f1d\u5b50\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306e\u6a5f\u68b0\u5b66\u7fd2\u5206\u6790\u306b\u3088\u308a\u3001\u85ac\u7269\u518d\u5229\u7528\u306e\u6f5c\u5728\u7684\u306a\u6a19\u7684\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f<\/span><\/a><\/p>\n<div class=\"text-s\">2023\u5e74\u3001\u30ea\u30b5\u30fc\u30c1\u30b9\u30af\u30a8\u30a2<\/div>\n<\/div>\n<div class=\"buttons text-s\"><\/div>\n<\/li>\n<li class=\"ListArticleItem u-margin-l-bottom\">\n<div class=\"sub-heading u-margin-xs-bottom\">\n<p id=\"citing-articles-article-3-title\" class=\"u-font-serif\"><a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1002\/ptr.7994\" target=\"_blank\" rel=\"noopener\"><span class=\"anchor-text\">PI3K\/Akt\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u6a19\u7684\u3068\u3057\u305f\u865a\u8840\u6027\u8133\u5352\u4e2d\u306b\u304a\u3051\u308b\u690d\u7269\u7642\u6cd5\u306e\u9032\u6b69<\/span><\/a><\/p>\n<div class=\"text-s\">2023\u5e74\u3001\u690d\u7269\u7642\u6cd5\u7814\u7a76<\/div>\n<\/div>\n<div class=\"buttons text-s\"><\/div>\n<\/li>\n<\/ul>\n<\/div>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889\">\u30bd\u30fc\u30b9<\/a><\/p>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>This suggests that breviscapine may significantly improve the cognitive function of CCI rats and reduce the pathological damage of ischemic neurons, and its mechanism may be related to the inhibition of NLRP3 inflammasome activation and pyroptosis pathway in brain tissue [211].<\/p>","protected":false},"author":1,"featured_media":5371,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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