{"id":5177,"date":"2024-01-16T12:37:46","date_gmt":"2024-01-16T12:37:46","guid":{"rendered":"https:\/\/farlong.com\/?p=5177"},"modified":"2024-01-27T10:26:20","modified_gmt":"2024-01-27T10:26:20","slug":"breviscapine-remodels-myocardial-glucose-and-lipid-metabolism-by-regulating-serotonin-to-alleviate-doxorubicin-induced-cardiotoxicity","status":"publish","type":"post","link":"https:\/\/directcm.com\/ja\/breviscapine-remodels-myocardial-glucose-and-lipid-metabolism-by-regulating-serotonin-to-alleviate-doxorubicin-induced-cardiotoxicity\/","title":{"rendered":"\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3067\u5fc3\u7b4b\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u3068\u8102\u8cea\u306e\u4ee3\u8b1d\u3092\u6539\u9020\u3057\u3001\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u8a98\u767a\u6027\u5fc3\u6bd2\u6027\u3092\u8efd\u6e1b\u3057\u307e\u3059\u3002"},"content":{"rendered":"<p>Meng-Jiao Li, 1 , 2 , \u2020 Wen-She Sun, 1 , \u2020 Yang Yuan, 1 , \u2020 Yu-Kun Zhang, 1 , 2 Qi Lu, 1 , 2 Yuan-Zhen Gao, 1 , 2 Ting Ye, 1 , 2 \u304a\u3088\u3073 Dong-Ming Xing \u5bfe\u5fdc\u8457\u8005 1 , 3 ,*<\/p>\n<div id=\"abstract-a.k.b.p\" class=\"tsec sec\" lang=\"en\">\n<h2 id=\"abstract-a.k.b.ptitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u62bd\u8c61\u7684\u306a<\/h2>\n<div>\n<p class=\"p p-first\"><strong>\u76ee\u7684:<\/strong>\u00a0\u5e83\u57df\u6297\u304c\u3093\u5264\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3 (Dox) \u306f\u5fc3\u6bd2\u6027\u306e\u767a\u751f\u7387\u304c\u9ad8\u304f\u3001\u85ac\u5264\u306e\u81e8\u5e8a\u5fdc\u7528\u3068\u60a3\u8005\u306e\u751f\u6d3b\u306e\u8cea\u306b\u91cd\u5927\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u3053\u3053\u3067\u306f\u3001Dox \u304c\u5fc3\u7b4b\u30a8\u30cd\u30eb\u30ae\u30fc\u3068\u53ce\u7e2e\u6a5f\u80fd\u3092\u3069\u306e\u3088\u3046\u306b\u8abf\u7bc0\u3059\u308b\u304b\u3092\u8a55\u4fa1\u3057\u3001\u3053\u308c\u306f\u95a2\u9023\u3059\u308b\u4fdd\u8b77\u85ac\u306e\u958b\u767a\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p><strong>\u65b9\u6cd5:<\/strong>\u00a0\u30de\u30a6\u30b9\u306b\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u3068\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306b\u3088\u308b\u6cbb\u7642\u3092\u65bd\u3057\u305f\u3002\u5fc3\u6a5f\u80fd\u306f\u5fc3\u30a8\u30b3\u30fc\u691c\u67fb\u306b\u3088\u3063\u3066\u5206\u6790\u3055\u308c\u3001Dox \u3092\u4ecb\u3057\u305f\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306f\u5358\u96e2\u3055\u308c\u305f\u5fc3\u7b4b\u7d30\u80de\u3067\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u5fc3\u81d3\u4fdd\u8b77\u4f5c\u7528\u3068\u6297\u816b\u760d\u4f5c\u7528\u306e\u4e8c\u91cd\u4f5c\u7528\u304c\u3001\u30de\u30a6\u30b9\u4e73\u623f\u816b\u760d\u30e2\u30c7\u30eb\u3067\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><strong>\u7d50\u679c\uff1a<\/strong>\u00a0\u79c1\u305f\u3061\u306f\u3001Dox \u304c\u30b0\u30eb\u30b3\u30fc\u30b9\u6442\u53d6\u91cf\u306e\u6e1b\u5c11\u3068\u8102\u80aa\u9178\u9178\u5316\u306e\u5897\u52a0\u306b\u3088\u308a\u5fc3\u7b4b\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3092\u59a8\u5bb3\u3057\u3001ATP \u751f\u7523\u901f\u5ea6\u306e\u4f4e\u4e0b\u3001\u9178\u7d20\u6d88\u8cbb\u901f\u5ea6\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u5897\u52a0\u3001\u3055\u3089\u306b\u30a8\u30cd\u30eb\u30ae\u30fc\u4e0d\u8db3\u3092\u5f15\u304d\u8d77\u3053\u3057\u3066\u5fc3\u7b4b\u306e\u8102\u80aa\u9178\u6442\u53d6\u91cf\u3092\u9ad8\u3081\u3001DIC \u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u767a\u9054\u3002\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u30bb\u30ed\u30c8\u30cb\u30f3-\u30b0\u30eb\u30b3\u30fc\u30b9-\u5fc3\u7b4bPI3K\/AKT\u30eb\u30fc\u30d7\u3092\u8abf\u7bc0\u3057\u3001\u5fc3\u81d3\u306b\u3088\u308b\u30b0\u30eb\u30b3\u30fc\u30b9\u5229\u7528\u3092\u5897\u52a0\u3055\u305b\u3001\u8102\u8cea\u9178\u5316\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u3001ATP\u751f\u6210\u52b9\u7387\u3092\u9ad8\u3081\u3001\u5fc3\u7b4b\u30a8\u30cd\u30eb\u30ae\u30fc\u6052\u5e38\u6027\u3092\u56de\u5fa9\u3057\u307e\u3059\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u5f37\u5316\u3057\u307e\u3059\u00a0<em>\u7d4c\u7531<\/em>\u00a0PINK1\/\u30d1\u30fc\u30ad\u30f3\u7d4c\u8def\u306f\u3001Dox \u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u640d\u50b7\u3057\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u84c4\u7a4d\u3092\u9664\u53bb\u3057\u3001\u5fc3\u81d3\u306e\u7dda\u7dad\u5316\u3068\u708e\u75c7\u306e\u7a0b\u5ea6\u3092\u8efd\u6e1b\u3057\u3001\u5fc3\u81d3\u306e\u5fae\u5c0f\u74b0\u5883\u306e\u6052\u5e38\u6027\u3092\u56de\u5fa9\u3057\u307e\u3059\u3002\u91cd\u8981\u306a\u306e\u306f\u3001\u305d\u306e\u4f4e\u3044\u708e\u75c7\u30ec\u30d9\u30eb\u304c\u9aa8\u9ac4\u7cfb\u514d\u75ab\u6291\u5236\u7d30\u80de\u306e\u6d78\u6f64\u3092\u8efd\u6e1b\u3057\u3001\u3053\u306e\u52b9\u679c\u304c Dox \u306e\u6297\u816b\u760d\u52b9\u679c\u3068\u76f8\u4e57\u4f5c\u7528\u3059\u308b\u3053\u3068\u3067\u3059\u3002<\/p>\n<p class=\"p p-last\"><strong>\u7d50\u8ad6\uff1a<\/strong>\u00a0\u6211\u3005\u306e\u767a\u898b\u306f\u3001Dox \u306b\u3088\u308b\u5fc3\u81d3\u4ee3\u8b1d\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u7834\u58ca\u304c\u5fc3\u6bd2\u6027\u306e\u91cd\u8981\u306a\u8981\u56e0\u3067\u3042\u308a\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u304c\u5fc3\u7b4b\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u304a\u3088\u3073\u8102\u8cea\u4ee3\u8b1d\u306e\u91cd\u8981\u306a\u8abf\u7bc0\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u5fc3\u7b4b\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u6052\u5e38\u6027\u3068\u640d\u50b7\u3057\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30bf\u30a4\u30e0\u30ea\u30fc\u306a\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u306f\u3001\u30a2\u30f3\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u8a98\u767a\u6027\u5fc3\u6bd2\u6027\u306e\u4e88\u9632\u306b\u76f8\u4e57\u7684\u306b\u8ca2\u732e\u3057\u3001\u816b\u760d\u6cbb\u7642\u306e\u52b9\u7387\u3092\u5411\u4e0a\u3055\u305b\u307e\u3059\u3002<\/p>\n<\/div>\n<div class=\"sec\"><strong class=\"kwd-title\">\u30ad\u30fc\u30ef\u30fc\u30c9:\u00a0<\/strong><span class=\"kwd-text\">\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u3001DIC\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u3001PINK1\/\u30d1\u30fc\u30ad\u30f3<\/span><\/div>\n<\/div>\n<div id=\"s1\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"s1title\" class=\"head no_bottom_margin ui-helper-clearfix\">\u5c0e\u5165<\/h2>\n<p class=\"p p-first\">\u30a2\u30f3\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u7cfb\u6297\u751f\u7269\u8cea\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3 (Dox) \u306f\u3001\u56fa\u5f62\u816b\u760d\u3001\u767d\u8840\u75c5\u3001\u30ea\u30f3\u30d1\u816b\u3001\u4e73\u304c\u3093\u306e\u6cbb\u7642\u306b\u975e\u5e38\u306b\u52b9\u679c\u7684\u306a\u6297\u304c\u3093\u5264\u3067\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B43\" aria-expanded=\"false\" aria-haspopup=\"true\">\u7af9\u6751\u3001\u85e4\u539f\u30012007<\/a>\uff09\u3002 Dox \u306e\u4f7f\u7528\u306f\u3001Dox \u8a98\u767a\u6027\u5fc3\u7b4b\u75c7 (DIC) \u3068\u3057\u3066\u77e5\u3089\u308c\u308b\u9032\u884c\u6027\u3001\u6162\u6027\u3001\u751f\u547d\u3092\u8105\u304b\u3059\u5fc3\u7b4b\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B20\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ea\u30fc\u30d0\u30a4\u30b9\u4ed6\u30012017<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B37\" aria-expanded=\"false\" aria-haspopup=\"true\">Sawicki \u4ed6\u30012021<\/a>\uff09\u3002\u6ce8\u76ee\u3059\u3079\u304d\u3053\u3068\u306b\u3001\u304c\u3093\u60a3\u8005\u3067\u306f\u3001\u85ac\u7269\u95a2\u9023\u306e\u5fc3\u6bd2\u6027\u306b\u3088\u308b\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u304c\u3001\u816b\u760d\u81ea\u4f53\u307e\u305f\u306f\u518d\u767a\u306b\u3088\u308b\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u3092\u4e0a\u56de\u3063\u3066\u3044\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B24\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ea\u30e5\u30fc\u307b\u304b\u30012017<\/a>\uff09\u3002\u5fc3\u6bd2\u6027\u306b\u8d77\u56e0\u3059\u308b DIC \u306f\u3001\u500b\u4eba\u306e\u611f\u53d7\u6027\u306b\u3088\u3063\u3066\u306f\u3001\u4f4e\u7528\u91cf\u306e Dox \u306e\u6295\u4e0e\u5f8c\u306b\u767a\u751f\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B27\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30de\u30af\u30b4\u30fc\u30ef\u30f3\u307b\u304b\u30012017<\/a>\uff09\u3002\u75ab\u5b66\u7814\u7a76\u3067\u306f\u3001\u80a5\u6e80\u3001\u7cd6\u5c3f\u75c5\u3001\u809d\u75be\u60a3\u306a\u3069\u306e\u4ee3\u8b1d\u7570\u5e38\u304c DIC \u306e\u30ea\u30b9\u30af\u5897\u52a0\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u3001\u307e\u305f Dox \u304c\u5fc3\u81d3\u306b\u3088\u308b\u30b0\u30eb\u30b3\u30fc\u30b9\u306e\u5438\u53ce\u3092\u5f37\u529b\u306b\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001Dox \u304c\u5fc3\u81d3\u306e\u6a5f\u80fd\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067 DIC \u306e\u767a\u75c7\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5fc3\u81d3\u306e\u4ee3\u8b1d\u5fae\u5c0f\u74b0\u5883\u3002\u6700\u8fd1\u3001DIC \u306e\u6f5c\u5728\u7684\u306a\u5206\u5b50\u6a5f\u69cb\u306b\u95a2\u3059\u308b\u7814\u7a76\u306f\u3001\u30ec\u30c3\u30c9 OX \u30db\u30e1\u30aa\u30b9\u30bf\u30b7\u30b9\u306e\u4e0d\u5747\u8861\u3001\u30c8\u30dd\u30a4\u30bd\u30e1\u30e9\u30fc\u30bc II\u03b2 (Top2b) \u306b\u3088\u308b\u8ee2\u5199\u963b\u5bb3\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u969c\u5bb3\u3001\u304a\u3088\u3073 Ca \u306b\u7126\u70b9\u3092\u5f53\u3066\u3066\u3044\u307e\u3059\u3002<sup>2+<\/sup>-\u7570\u5e38\u306e\u51e6\u7406 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B45\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30f4\u30a7\u30b8\u30dd\u30f3\u30b5\u3068\u30a4\u30a7\u30fc\u30012014<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B15\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ab\u30ea\u30e4\u30ca\u30e9\u30de\u30f3\u30012020<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B13\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30cf\u30eb\u30b9\u30c8\u3089\u30012021<\/a>\uff09\u3002\u5fc3\u81d3\u306f\u4f53\u5185\u3067\u6700\u3082\u591a\u304f\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u6d88\u8cbb\u3057\u307e\u3059\u304c\u3001Dox \u306f\u5fc3\u81d3\u306e\u4ee3\u8b1d\u3092\u518d\u69cb\u7bc9\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001DIC \u306e\u958b\u767a\u3092\u4fc3\u9032\u3059\u308b\u5909\u5316\u306f\u5b8c\u5168\u306b\u306f\u7406\u89e3\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u5fc3\u81d3\u4ee3\u8b1d\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u8abf\u7bc0\u3092\u901a\u3058\u3066 DIC \u3092\u4e88\u9632\u3059\u308b\u305f\u3081\u306e\u6cbb\u7642\u6226\u7565\u306f\u78ba\u7acb\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<p>\u5fc3\u81d3\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306b\u306f\u3001ATP \u751f\u6210\u307e\u305f\u306f\u751f\u5408\u6210\u306e\u305f\u3081\u306e\u5404\u30af\u30e9\u30b9\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u57fa\u8cea\u306e\u4f7f\u7528\u3092\u3082\u305f\u3089\u3059\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u7d4c\u8def\u306e\u8907\u96d1\u306a\u30bb\u30c3\u30c8\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u6700\u3082\u9855\u8457\u306a\u7279\u5fb4\u306f\u3001\u767a\u9054\u306e\u5909\u5316\u3001\u6804\u990a\u72b6\u614b\u3001\u6162\u6027\u306e\u75c5\u614b\u751f\u7406\u5b66\u7684\u72b6\u614b\u3001\u85ac\u7406\u5b66\u7684\u4ecb\u5165\u306a\u3069\u306e\u3055\u307e\u3056\u307e\u306a\u523a\u6fc0\u306b\u5fdc\u7b54\u3057\u3066\u793a\u3055\u308c\u308b\u4ee3\u8b1d\u306e\u67d4\u8edf\u6027\u3067\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B29\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6751\u91cd\u307b\u304b\u30012020<\/a>\uff09\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u3001\u5fc3\u7b4b\u7d30\u80de\u306e\u4f53\u7a4d\u306e 3 \u5206\u306e 1 \u3092\u5360\u3081\u3001\u5fc3\u81d3\u3067\u5229\u7528\u3055\u308c\u308b ATP \u306e 95% \u4ee5\u4e0a\u3092\u751f\u6210\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u7d30\u80de\u5185\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u6052\u5e38\u6027\u3001\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3001\u304a\u3088\u3073\u7d30\u80de\u6b7b\u3092\u8abf\u7bc0\u3059\u308b\u591a\u76ee\u7684\u7d30\u80de\u5c0f\u5668\u5b98\u3067\u3042\u308a\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u8abf\u548c\u306e\u4e2d\u5fc3\u3067\u3059\u3002\u5909\u63db (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B18\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30b3\u30eb\u30a6\u30a3\u30c3\u30c4\u3089\u30012013<\/a>\uff09\u3002\u5fc3\u81d3\u306f\u3001ATP \u751f\u6210\u306e\u305f\u3081\u306b\u70ad\u6c34\u5316\u7269\u3001\u8102\u8cea\u3001\u30a2\u30df\u30ce\u9178\u3001\u30b1\u30c8\u30f3\u4f53\u306a\u3069\u306e\u3042\u3089\u3086\u308b\u7a2e\u985e\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u57fa\u8cea\u3092\u5229\u7528\u3067\u304d\u307e\u3059\u304c\u3001\u4f7f\u7528\u3055\u308c\u308b\u57fa\u8cea\u306f\u5fc3\u81d3\u306e\u52b9\u7387\u306b\u5f71\u97ff\u3057\u307e\u3059\u3002\u8102\u80aa\u9178\u6fc3\u5ea6\u306e\u4e0a\u6607\u3068\u9178\u5316\u306f\u3001\u80a5\u6e80\u3084\u7cd6\u5c3f\u75c5\u306b\u95a2\u9023\u3057\u3066\u30b0\u30eb\u30b3\u30fc\u30b9\u9178\u5316\u306e\u6e1b\u5c11\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B34\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30e9\u30f3\u30c9\u30eb\u3089\u30011963<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B23\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ea\u30fc\u3068\u30c1\u30e3\u30f3\u30012016<\/a>\uff09\u3002\u5fc3\u6a5f\u80fd\u4e0d\u5168\u306f\u3001\u5fc3\u7b4b\u9178\u7d20\u6d88\u8cbb\u91cf\u306e\u5897\u52a0\u3001\u5fc3\u81d3\u52b9\u7387\u306e\u4f4e\u4e0b\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u8102\u80aa\u9178\u9178\u5316\uff08FAO\uff09\u306e\u5897\u52a0\u304c\u5fc3\u6a5f\u80fd\u306b\u6709\u5bb3\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B25\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ed\u30d1\u30b7\u30e5\u30af\u3089\u30012010<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B26\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ed\u30d1\u30b7\u30e5\u30af\u3089\u30012021<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B54\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5c71\u672c\u3068\u4f50\u91ce\u30012022\u5e74<\/a>\uff09\u3002\u9ad8FAO\u306e\u60aa\u5f71\u97ff\u306e\u6839\u5e95\u306b\u3042\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e1\u3064\u306f\u3001\u9178\u7d20\u52b9\u7387\u306e\u4f4e\u4e0b\u3068\u8102\u80aa\u9178\u8a98\u5c0e\u4f53\u306e\u30ec\u30d9\u30eb\u306e\u5897\u52a0\u3067\u3042\u308a\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u8131\u5171\u5f79\u306b\u3088\u3063\u3066\u3055\u3089\u306b\u52b9\u7387\u304c\u4f4e\u4e0b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u5b9f\u969b\u3001DIC \u3067\u306f\u8102\u8cea\u904e\u9178\u5316 (LP) \u306e\u4e0a\u6607\u304c\u89b3\u5bdf\u3055\u308c\u3066\u304a\u308a\u3001FAO \u306e\u4e0a\u6607\u304c\u5fc3\u81d3\u640d\u50b7\u306e\u91cd\u8981\u306a\u7d4c\u8def\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001Dox\u6cbb\u7642\u4e2d\u306e\u5fc3\u81d3\u306e\u4ee3\u8b1d\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u306b\u3088\u308a\u8102\u80aa\u9178\u306e\u53d6\u308a\u8fbc\u307f\u3068\u9178\u5316\u304c\u5897\u52a0\u3057\u3001\u305d\u306e\u7d50\u679cATP\u751f\u7523\u52b9\u7387\u304c\u4f4e\u4e0b\u3057\u3001\u9ad8\u3044\u9178\u7d20\u6d88\u8cbb\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u4f34\u3044\u3001\u5fc3\u81d3\u52b9\u7387\u306e\u4f4e\u4e0b\u304c\u8102\u80aa\u9178\u5229\u7528\u306e\u5f37\u5316\u306b\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u3055\u308c\u308b\u3068\u3044\u3046\u4eee\u8aac\u3092\u7acb\u3066\u3066\u3044\u307e\u3059\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u640d\u50b7\u306b\u3088\u308a\u3001DIC \u306e\u9032\u884c\u304c\u52a0\u901f\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u75ab\u5b66\u7814\u7a76\u3067\u306f\u3001\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u304c\u8c4a\u5bcc\u306a\u98df\u54c1\u3092\u5b9a\u671f\u7684\u306b\u6442\u53d6\u3059\u308b\u3068\u3001\u591a\u304f\u306e\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u8efd\u6e1b\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u304a\u308a\u3001\u591a\u304f\u306e\u5929\u7136\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u5316\u5408\u7269\u304c\u5fc3\u81d3\u6a5f\u80fd\u3092\u4fdd\u8b77\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B38\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30b7\u30e3\u30d0\u30e9\u30e9\u4ed6\u30012017<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B42\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30b7\u30e3\u30d7\u30c8\u30e9\u3089\u30012022<\/a>).\u00a0<em>\u30a8\u30ea\u30b2\u30ed\u30f3\u30fb\u30d6\u30ec\u30d3\u30b9\u30ab\u30d7\u30b9<\/em>\u3001 \u3068\u3057\u3066\u3082\u77e5\u3089\u308c\u3066\u3044\u308b\u00a0<em>\u30a2\u30b7\u30a7\u30eb\u30d1\u30fb\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3<\/em>\u00a0\u307e\u305f\u306f\u30a2\u30dd\u30b7\u30cc\u30e0\u306f\u3001600 \u5e74\u4ee5\u4e0a\u306b\u308f\u305f\u3063\u3066\u4f7f\u7528\u3055\u308c\u3066\u304d\u305f\u4f1d\u7d71\u7684\u306a\u30cf\u30fc\u30d6\u3067\u3059\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u6210\u5206\u3067\u3059\u3002\u00a0<em>\u30a8\u30ea\u30b2\u30ed\u30f3\u30fb\u30d6\u30ec\u30d3\u30b9\u30ab\u30d7\u30b9<\/em>\u00a0\u6297\u9178\u5316\u4f5c\u7528\u3001\u6297\u708e\u75c7\u4f5c\u7528\u3001\u6297\u816b\u760d\u4f5c\u7528\u306a\u3069\u306e\u5e45\u5e83\u3044\u85ac\u7406\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B10\" aria-expanded=\"false\" aria-haspopup=\"true\">Gao \u4ed6\u30012017<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B48\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30a6\u30a7\u30f3\u3089\u30012021<\/a>\uff09\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u6ce8\u5c04\u306f\u3001\u4e2d\u56fd\u3067\u5fc3\u8840\u7ba1\u75be\u60a3\u304a\u3088\u3073\u8133\u8840\u7ba1\u75be\u60a3\u306e\u6cbb\u7642\u306b\u6700\u3082\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u53e4\u5178\u7684\u306a\u85ac\u5264\u3067\u3042\u308a\u3001\u4e2d\u56fd\u306e\u75c5\u9662\u306e\u6551\u6025\u6cbb\u7642\u3067\u3082\u91cd\u8981\u306a\u85ac\u5264\u3067\u3059\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u300120 \u5e74\u4ee5\u4e0a\u306b\u308f\u305f\u3063\u3066\u9ad8\u8840\u5727\u3001\u8133\u585e\u6813\u75c7\u3001\u8133\u8840\u7ba1\u75be\u60a3\u306e\u6cbb\u7642\u306b\u81e8\u5e8a\u5fdc\u7528\u3055\u308c\u3066\u304d\u307e\u3057\u305f (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B50\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30a6\u30fc\u3089\u30012019<\/a>\uff09\u3002\u3057\u304b\u3057\u3001\u5316\u5b66\u7642\u6cd5\u85ac\u306b\u3088\u308b\u5fc3\u81d3\u640d\u50b7\u306b\u5bfe\u3059\u308b\u4fdd\u8b77\u52b9\u679c\u306b\u3064\u3044\u3066\u306f\u3001\u73fe\u6642\u70b9\u3067\u306f\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<p class=\"p p-last\">\u3053\u306e\u7814\u7a76\u3067\u306f\u3001H9c2 \u30e9\u30c3\u30c8\u5fc3\u7b4b\u7d30\u80de\u3068 C57BL\/6 \u30de\u30a6\u30b9\u3092\u4f7f\u7528\u3057\u3066\u30a2\u30f3\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u8a98\u767a\u5fc3\u7b4b\u640d\u50b7\u30e2\u30c7\u30eb\u3092\u78ba\u7acb\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001DIC \u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u6f5c\u5728\u7684\u306a\u52b9\u679c\u3068\u305d\u306e\u8003\u3048\u3089\u308c\u308b\u5206\u5b50\u6a5f\u69cb\u3092\u8abf\u67fb\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u8abf\u7bc0\u5206\u5c90\u30bb\u30ed\u30c8\u30cb\u30f3\u7d4c\u8def\u3092\u901a\u3058\u3066\u5fc3\u7b4b\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u5229\u7528\u52b9\u7387\u3092\u6539\u5584\u3057\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u6a5f\u80fd\u3092\u767a\u63ee\u3057\u3066\u3001\u9178\u7d20\u6d88\u8cbb\u91cf\u304c\u4f4e\u3044\u3068\u304d\u306b\u9ad8\u3044ATP\u751f\u7523\u52b9\u7387\u3068\u4f4e\u3044\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u30ec\u30d9\u30eb\u3092\u9054\u6210\u3057\u3001\u53e4\u5178\u7684\u306a\u5fc3\u7b4b\u7d30\u80de\u3092\u6d3b\u6027\u5316\u3067\u304d\u308b\u3053\u3068\u3092\u4f53\u7cfb\u7684\u306b\u89e3\u660e\u3057\u307e\u3057\u305f\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2PINK1\/\u30d1\u30fc\u30ad\u30f3\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u7d4c\u8def\u306f\u3001\u640d\u50b7\u3057\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306eDox\u8a98\u767a\u6027\u84c4\u7a4d\u3092\u6392\u9664\u3057\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u30a8\u30cd\u30eb\u30ae\u30fc\u751f\u7523\u306e\u8abf\u7bc0\u3092\u8abf\u6574\u3057\u3001\u5fc3\u81d3\u5fae\u5c0f\u74b0\u5883\u306e\u6052\u5e38\u6027\u3092\u5f90\u3005\u306b\u56de\u5fa9\u3057\u307e\u3059\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u8a98\u767a\u6027\u5fc3\u6bd2\u6027\u306b\u5bfe\u3059\u308b\u6f5c\u5728\u7684\u306a\u65b0\u898f\u4fdd\u8b77\u5264\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n<div id=\"s2\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"s2title\" class=\"head no_bottom_margin ui-helper-clearfix\">\u6750\u6599\u3068\u65b9\u6cd5<\/h2>\n<p class=\"p p-first\">\u3059\u3079\u3066\u306e\u52d5\u7269\u7814\u7a76\u306f\u9752\u5cf6\u5927\u5b66\u52d5\u7269\u7ba1\u7406\u4f7f\u7528\u59d4\u54e1\u4f1a\u306b\u3088\u3063\u3066\u627f\u8a8d\u3055\u308c\u3001\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u5f93\u3063\u3066\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<div id=\"s2-1\" class=\"sec\">\n<h3 id=\"s2-1title\">\u8a66\u85ac<\/h3>\n<p class=\"p p-first-last\">\u4ee5\u4e0b\u306e\u8a66\u85ac\u3092\u4f7f\u7528\u3057\u307e\u3057\u305f: DMEM\u3001FBS\u3001\u30da\u30cb\u30b7\u30ea\u30f3\/\u30b9\u30c8\u30ec\u30d7\u30c8\u30de\u30a4\u30b7\u30f3 (Meilunbio\u3001\u4e2d\u56fd\u3001\u5927\u9023)\u3001cTnI Elisa \u30ad\u30c3\u30c8 (Sangon Biotech\u3001\u4e2d\u56fd\u3001\u4e0a\u6d77)\u3001TNF-\u03b1\u3001IL-1\u03b2\u3001\u304a\u3088\u3073 IL-6 Elisa \u30ad\u30c3\u30c8 (MyBioSource\u3001\u30b5\u30f3\u30c7\u30a3\u30a8\u30b4\u3001\u7c73\u56fd\uff09\u3001MDA \u30ad\u30c3\u30c8\u3001SOD \u30ad\u30c3\u30c8\u3001\u304a\u3088\u3073 NADH \u30ad\u30c3\u30c8\uff08Solarbio\u3001\u5317\u4eac\u3001\u4e2d\u56fd\uff09\u3001CCK-8 \u30ad\u30c3\u30c8\uff08Beyotime Biotechnology\u3001\u4e0a\u6d77\u3001\u4e2d\u56fd\uff09\u3001ROS \u86cd\u5149\u5b9a\u91cf\u30ad\u30c3\u30c8\u3001JC-1 \u86cd\u5149\u8272\u7d20\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u62bd\u51fa\u30ad\u30c3\u30c8\u3001\u304a\u3088\u3073BCA\u30ad\u30c3\u30c8\uff08Meilunbio\u3001\u5927\u9023\u3001\u4e2d\u56fd\uff09\u3002 IL-1 (1:100)\u3001PINK1(1:1,000)\u3001\u30d1\u30fc\u30ad\u30f3 (1:1,000)\u3001AMPK(1:1,000)\u3001Akt (1:1,000)\u3001P13K(1:1,000)\u3001Tom20 (1:1,000) \u3001\u03b2-\u30c1\u30e5\u30fc\u30d6\u30ea\u30f3 (1:1,000)\u3001mTOR (1:1,000)\u3001\u304a\u3088\u3073 HRP \u7d50\u5408 GAPDH (1:1,000) \u6297\u4f53\u306f\u3001Abclonal Biotechnology (\u6b66\u6f22\u3001\u4e2d\u56fd) \u304b\u3089\u5165\u624b\u3057\u307e\u3057\u305f\u3002 RIPA \u6eb6\u89e3\u30d0\u30c3\u30d5\u30a1\u30fc\u3068\u30ed\u30fc\u30c7\u30a3\u30f3\u30b0 \u30d0\u30c3\u30d5\u30a1\u30fc\u306f Meilunbio (\u5927\u9023\u3001\u4e2d\u56fd) \u304b\u3089\u8cfc\u5165\u3057\u307e\u3057\u305f\u3002 PVDF \u819c\u306f Merck (\u7c73\u56fd\u30cb\u30e5\u30fc\u30b8\u30e3\u30fc\u30b8\u30fc\u5dde) \u304b\u3089\u5165\u624b\u3057\u307e\u3057\u305f\u3002 DMSO \u306f Macklin (\u4e2d\u56fd\u3001\u4e0a\u6d77) \u304b\u3089\u8cfc\u5165\u3057\u3001\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u3001\u304a\u3088\u3073\u30c7\u30af\u30b9\u30e9\u30be\u30ad\u30b5\u30f3\u306f Widely (\u4e2d\u56fd\u3001\u6b66\u6f22) \u304b\u3089\u8cfc\u5165\u3057\u307e\u3057\u305f\u3002 Mdivi-1 \u963b\u5bb3\u5264\u306f\u3001Selleck Chemicals (\u30d2\u30e5\u30fc\u30b9\u30c8\u30f3\u3001\u7c73\u56fd) \u304b\u3089\u8cfc\u5165\u3057\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n<div id=\"s2-2\" class=\"sec\">\n<h3 id=\"s2-2title\">\u7d30\u80de\u57f9\u990a\u6761\u4ef6\u3068\u7d30\u80de\u682a<\/h3>\n<p class=\"p p-first\">\u7d30\u80de\u57f9\u990a\u7528\u306e\u57f9\u5730\u304a\u3088\u3073\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f Gibco-Invitrogen (\u7c73\u56fd\u30ab\u30ea\u30d5\u30a9\u30eb\u30cb\u30a2\u5dde\u30ab\u30fc\u30eb\u30ba\u30d0\u30c3\u30c9) \u304b\u3089\u8cfc\u5165\u3057\u3001\u30d7\u30e9\u30b9\u30c1\u30c3\u30af\u88fd\u54c1\u306f Corning (\u7c73\u56fd\u30cb\u30e5\u30fc\u30e8\u30fc\u30af\u5dde\u30b3\u30fc\u30cb\u30f3\u30b0) \u304b\u3089\u8cfc\u5165\u3057\u307e\u3057\u305f\u3002 H9c2 \u80ce\u5150\u30e9\u30c3\u30c8\u5fc3\u81d3\u7531\u6765\u5fc3\u7b4b\u82bd\u7d30\u80de (ATCC\u3001CRL-1446) \u3092\u300110% \u30a6\u30b7\u80ce\u5150\u8840\u6e05\u3001100 \u5358\u4f4d\/ml \u30da\u30cb\u30b7\u30ea\u30f3 G \u30ca\u30c8\u30ea\u30a6\u30e0\u3001\u304a\u3088\u3073 100 \u03bcg\/ml \u786b\u9178\u30b9\u30c8\u30ec\u30d7\u30c8\u30de\u30a4\u30b7\u30f3\u3092\u542b\u3080 DMEM \u4e2d\u3067\u57f9\u990a\u3057\u307e\u3057\u305f (37\u00b0C\u30015% CO<sub>2<\/sub>\uff09\u3002 MCF-7 \u30d2\u30c8\u8ee2\u79fb\u6027\u4e73\u304c\u3093\u7d30\u80de (iCell\u3001iCell-h129) \u3092\u300110% \u30a6\u30b7\u80ce\u5150\u8840\u6e05\u3001100 \u5358\u4f4d\/ml \u30da\u30cb\u30b7\u30ea\u30f3 G \u30ca\u30c8\u30ea\u30a6\u30e0\u3001\u304a\u3088\u3073 100 \u03bcg\/ml \u786b\u9178\u30b9\u30c8\u30ec\u30d7\u30c8\u30de\u30a4\u30b7\u30f3\u3092\u6dfb\u52a0\u3057\u305f 1,640 \u57f9\u5730\u3067\u57f9\u990a\u3057\u307e\u3057\u305f\u3002 4T1 \u30de\u30a6\u30b9\u4e73\u304c\u3093\u7d30\u80de (ATCC\u3001FS-0158) \u3092\u300110% \u30a6\u30b7\u80ce\u5150\u8840\u6e05\u3001100 \u5358\u4f4d\/ml \u30da\u30cb\u30b7\u30ea\u30f3 G \u30ca\u30c8\u30ea\u30a6\u30e0\u3001\u304a\u3088\u3073 100 \u03bcg\/ml \u786b\u9178\u30b9\u30c8\u30ec\u30d7\u30c8\u30de\u30a4\u30b7\u30f3\u3092\u6dfb\u52a0\u3057\u305f DMEM \u57f9\u5730\u3067\u57f9\u990a\u3057\u307e\u3057\u305f\u3002<\/p>\n<p class=\"p p-last\">\u7d30\u80de\u304c 80 \uff5e 90% \u30b3\u30f3\u30d5\u30eb\u30a8\u30f3\u30b9\u306b\u9054\u3057\u305f\u3068\u304d\u306b\u5b9a\u671f\u7684\u306b\u7d99\u4ee3\u3057\u300196 \u30a6\u30a7\u30eb \u30d7\u30ec\u30fc\u30c8 (1 \u00d7 100) \u306b\u64ad\u7a2e\u3057\u307e\u3057\u305f\u3002<sup>4<\/sup>\u00a0\u7d30\u80de\/\u30a6\u30a7\u30eb)\u3002 H9c2 \u7d30\u80de\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e 5 \u03bcM Dox (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B12\" aria-expanded=\"false\" aria-haspopup=\"true\">\u90ed\u3089\u30012013<\/a>)\u30015\u03bcM Dox+20\u03bcM Dexra (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B35\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30b5\u30f3\u30b0\u30a6\u30a7\u30cb\u307b\u304b\u30012020<\/a>)\u3001\u307e\u305f\u306f 5 \u03bcM Dox + 200 \u03bcM \u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B22\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ea\u30fc\u3089\u30012022<\/a>) \u305d\u308c\u305e\u308c 24 \u6642\u9593\u3002 DMEM\u306e\u307f\u3067\u51e6\u7406\u3057\u305f\u7d30\u80de\u3092\u30d6\u30e9\u30f3\u30af\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u3057\u3066\u4f7f\u7528\u3057\u3001Dexra\u3092\u30dd\u30b8\u30c6\u30a3\u30d6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u3057\u3066\u4f7f\u7528\u3057\u307e\u3057\u305f\u3002\u6700\u5f8c\u306b\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5206\u88c2\u306e\u963b\u5bb3\u5264\u3067\u3042\u308b Mdivi-1 (5\u03bcM\u3001DMSO \u6eb6\u6db2) \u3082\u6ce8\u5c04\u3057\u307e\u3057\u305f (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B30\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30cb\u30e5\u30fc\u4ed6\u30012021<\/a>).<\/p>\n<\/div>\n<div id=\"s2-3\" class=\"sec\">\n<h3 id=\"s2-3title\">\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u8a55\u4fa1<\/h3>\n<p class=\"p p-first-last\">\u7d30\u80de\u5185 ROS \u30ec\u30d9\u30eb\u306f\u3001\u88fd\u9020\u696d\u8005\u306e\u6307\u793a\u306b\u5f93\u3063\u3066\u86cd\u5149\u8272\u7d20 DCFH-DA \u3092\u4f7f\u7528\u3057\u3066\u6e2c\u5b9a\u3057\u307e\u3057\u305f\u3002\u7c21\u5358\u306b\u8aac\u660e\u3059\u308b\u3068\u3001DCFH-DA \u6eb6\u6db2 (1 \u03bcM) \u3092 PBS \u3067\u8abf\u88fd\u3057\u30016 \u30a6\u30a7\u30eb \u30d7\u30ec\u30fc\u30c8\u3067\u57f9\u990a\u3057\u305f H9c2 \u7d30\u80de\u306b\u6dfb\u52a0\u3057\u305f\u5f8c\u300137\u2103\u3067 30 \u5206\u9593\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30c8\u3057\u307e\u3057\u305f\u3002\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30b7\u30e7\u30f3\u5f8c\u3001\u7d30\u80de\u3092PBS\u3067\u6d17\u6d44\u3057\u305f\u3002 Leica Microsystems, Ltd.\u306e\u86cd\u5149\u9855\u5fae\u93e1\u3092\u4f7f\u7528\u3057\u3066\u3001\u86cd\u5149\u9855\u5fae\u93e1\u5199\u771f\u3092\u500d\u738720\u500d\u3067\u64ae\u5f71\u3057\u305f\u3002ROS\u30ec\u30d9\u30eb\u306f\u3001Beckman\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30fc\u30bf\u30fc(Beckman\u3001\u30ab\u30ea\u30d5\u30a9\u30eb\u30cb\u30a2\u3001\u7c73\u56fd)\u3092\u7528\u3044\u3066\u5b9a\u91cf\u3057\u305f\u3002<\/p>\n<\/div>\n<div id=\"s2-4\" class=\"sec\">\n<h3 id=\"s2-4title\">\u9175\u7d20\u6307\u6570\u306e\u6c7a\u5b9a<\/h3>\n<p class=\"p p-first-last\">\uff33\uff2f\uff24\u304a\u3088\u3073\uff2e\uff21\uff24\uff28\u306e\u6d3b\u6027\u306f\u3001\u88fd\u9020\u696d\u8005\u306e\u6307\u793a\u306b\u5f93\u3063\u3066\u6d3b\u6027\u30a2\u30c3\u30bb\u30a4\u30ad\u30c3\u30c8\u3092\u4f7f\u7528\u3057\u3066\u6e2c\u5b9a\u3057\u305f\u3002\u5438\u5149\u5ea6\u304a\u3088\u3073\u767a\u5149\u306f\u3001\u30de\u30a4\u30af\u30ed\u30d7\u30ec\u30fc\u30c8\u30ea\u30fc\u30c0\u30fc\uff08Perkin Elmer\u3001\u7c73\u56fd\u30de\u30b5\u30c1\u30e5\u30fc\u30bb\u30c3\u30c4\u5dde\uff09\u3092\u4f7f\u7528\u3057\u3066\u6e2c\u5b9a\u3057\u305f\u3002<\/p>\n<\/div>\n<div id=\"s2-5\" class=\"sec\">\n<h3 id=\"s2-5title\">\u96fb\u5b50\u9855\u5fae\u93e1\u6cd5<\/h3>\n<p class=\"p p-first-last\">\u7d30\u80de\u3092 0.5% \u30b0\u30eb\u30bf\u30eb\u30a2\u30eb\u30c7\u30d2\u30c9\u56fa\u5b9a\u6db2\u3067 4 \u00b0C \u3067 15 \uff5e 30 \u5206\u9593\u56fa\u5b9a\u3057\u300110,000 \uff5e 13,000 rpm \u3067 5 \u5206\u9593\u9060\u5fc3\u5206\u96e2\u3057\u3066\u56de\u53ce\u3057\u307e\u3057\u305f\u3002\u7d30\u80de\u3092\u3055\u3089\u306b 3% \u30b0\u30eb\u30bf\u30eb\u30a2\u30eb\u30c7\u30d2\u30c9\u3067 4\u2103\u3067\u4e00\u6669\u56fa\u5b9a\u3057\u3001\u6b21\u306b 1% \u56db\u9178\u5316\u30aa\u30b9\u30df\u30a6\u30e0\u3067\u5ba4\u6e29\u3067 2 \u6642\u9593\u51e6\u7406\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\u3001\u30b5\u30f3\u30d7\u30eb\u3092\u30a2\u30bb\u30c8\u30f3\u52fe\u914d\u3067\u8131\u6c34\u3057\u3001Epon 812 \u306b\u5305\u57cb\u3057\u3001\u5149\u5b66\u4f4d\u7f6e\u6c7a\u3081\u3092\u884c\u3063\u3066\u8d85\u8584\u5207\u7247\u306b\u5207\u65ad\u3057\u307e\u3057\u305f\u3002\u5207\u7247\u3092\u9162\u9178\u30a6\u30e9\u30cb\u30eb\u3068\u30af\u30a8\u30f3\u9178\u925b\u3067\u4e8c\u91cd\u67d3\u8272\u3057\u305f\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u8d85\u5fae\u7d30\u69cb\u9020\u306f\u3001H-7650 \u900f\u904e\u578b\u96fb\u5b50\u9855\u5fae\u93e1 (\u65e5\u7acb\u3001\u6771\u4eac\u3001\u65e5\u672c) \u3092\u4f7f\u7528\u3057\u3066\u691c\u67fb\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n<div id=\"s2-6\" class=\"sec\">\n<h3 id=\"s2-6title\">\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u547c\u5438\u306e\u6e2c\u5b9a<\/h3>\n<p class=\"p p-first-last\">\u7d0410<sup>6<\/sup>\u00a0\u7d30\u80de\u3092\u4f7f\u7528\u3057\u3066\u3001O2K\u547c\u5438\u8a08\uff08Oroboros Instruments\u3001\u30aa\u30fc\u30b9\u30c8\u30ea\u30a2\uff09\u3067\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u547c\u5438\u3092\u6e2c\u5b9a\u3057\u307e\u3057\u305f\u3002\u9178\u7d20\u6fc3\u5ea6\u306f\u3001Oroboros DatLab 7.4 \u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3092\u4f7f\u7528\u3057\u3066\u6e2c\u5b9a\u304a\u3088\u3073\u5206\u6790\u3055\u308c\u307e\u3057\u305f\u3002\u7c21\u5358\u306b\u8a00\u3046\u3068\u3001\u7d30\u80de\u306e\u307f\u3067\u30ea\u30fc\u30af\u547c\u5438\u72b6\u614b\u304c\u8a18\u9332\u3055\u308c\u30015 mM ADP \u306e\u6dfb\u52a0\u306b\u3088\u308a\u96fb\u5b50\u4f1d\u9054\u304c\u30ea\u30f3\u9178\u5316\u3068\u5171\u5f79\u3057\u3001\u8907\u5408\u4f53 I \u306b\u3088\u3063\u3066\u30b5\u30dd\u30fc\u30c8\u3055\u308c\u308b\u72b6\u614b 3 \u306e\u547c\u5438\u304c\u8a18\u9332\u3055\u308c\u307e\u3057\u305f\u3002\u8907\u5408\u4f53 I \u3068\u8907\u5408\u4f53 II \u304b\u3089\u306e\u5e73\u884c\u96fb\u5b50\u5165\u529b\u306b\u3088\u308b\u6700\u5927\u72b6\u614b 3 \u547c\u5438\u306f\u300110 mM \u30b3\u30cf\u30af\u9178\u5869\u306e\u6dfb\u52a0\u306b\u3088\u3063\u3066\u8a18\u9332\u3055\u308c\u3001\u8907\u5408\u4f53 II \u306b\u652f\u3048\u3089\u308c\u305f\u547c\u5438\u306f 6.25 \u03bcM \u30ed\u30c6\u30ce\u30f3\u306e\u5b58\u5728\u4e0b\u3067\u6e2c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u6700\u5927\u306e\u96fb\u5b50\u79fb\u52d5\u5bb9\u91cf\u306f\u30015 \u03bcM \u30b7\u30a2\u30f3\u5316\u30ab\u30eb\u30dc\u30cb\u30eb p-(\u30c8\u30ea\u30d5\u30eb\u30aa\u30ed\u30e1\u30c8\u30ad\u30b7) \u30d5\u30a7\u30cb\u30eb\u30d2\u30c9\u30e9\u30be\u30f3 (FCCP) \u306e\u5b58\u5728\u4e0b\u3067\u8a18\u9332\u3055\u308c\u307e\u3057\u305f\u3002\u6700\u5f8c\u306b\u3001\u8907\u5408\u4f53\u2162\u3092\u5b8c\u6210\u3055\u305b\u3001\u3059\u3079\u3066\u306e\u96fb\u5b50\u4f1d\u9054\u3092\u906e\u65ad\u3059\u308b\u30a2\u30f3\u30c1\u30de\u30a4\u30b7\u30f3\uff08Ama\uff09\u3092\u6295\u4e0e\u3057\u3001\u9178\u7d20\u6d88\u8cbb\u7387\u3092\u975e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u9178\u7d20\u6d88\u8cbb\u91cf\u3068\u3057\u3066\u6e2c\u5b9a\u3057\u305f\u3002<\/p>\n<\/div>\n<div id=\"s2-7\" class=\"sec\">\n<h3 id=\"s2-7title\">\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u819c\u96fb\u4f4d\u306e\u5909\u5316 (\u0394\u03a8m) \u306e\u6e2c\u5b9a<\/h3>\n<p class=\"p p-first-last\">5.5&#039;,6.6&#039;-\u30c6\u30c8\u30e9\u30af\u30ed\u30ed-1.1&#039;,3.3&#039;-\u30c6\u30c8\u30e9\u30a8\u30c1\u30eb\u30d9\u30f3\u30ba\u30a4\u30df\u30c0\u30be\u30ea\u30eb\u30ab\u30eb\u30dc\u30b7\u30a2\u30cb\u30f3\u30e8\u30fc\u30b8\u30c9 (JC-1) \u67d3\u8272\u3092\u4f7f\u7528\u3057\u3066\u3001H9c2 \u7d30\u80de\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u819c\u96fb\u4f4d\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002\u7c21\u5358\u306b\u8aac\u660e\u3059\u308b\u3068\u3001\u6240\u5b9a\u306e\u5b9f\u9a13\u6761\u4ef6\u306b\u5f93\u3063\u3066\u3001H9c2 \u7d30\u80de\u3092\u6e29\u304b\u3044\u30c0\u30eb\u30d9\u30c3\u30b3\u30ea\u30f3\u9178\u7de9\u885d\u751f\u7406\u98df\u5869\u6c34 (DPBS) \u3067\u6d17\u6d44\u3057\u305f\u5f8c\u3001100 \u03bcL \u306e 2 \u03bcM JC-1 \u6eb6\u6db2 (\u30d5\u30a7\u30ce\u30fc\u30eb\u30ec\u30c3\u30c9\u3092\u542b\u307e\u306a\u3044 DMEM \u306b\u6df7\u5408) \u3067\u67d3\u8272\u3057\u3001\u6a19\u6e96\u7684\u306a\u7d30\u80de\u57f9\u990a\u4e0b\u3067\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30c8\u3057\u307e\u3057\u305f\u3002\u6697\u6240\u306730\u5206\u9593\u306e\u6761\u4ef6\u3002\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30b7\u30e7\u30f3\u5f8c\u3001\u7d30\u80de\u3092\u6e29DPBS\u3067\u6d17\u6d44\u3057\u3001Leica Microsystems CMS GmbH\u5012\u7acb\u86cd\u5149\u9855\u5fae\u93e1(Leica Camera AG\u3001\u30d0\u30eb\u30ca\u30c3\u30af\u3001\u30c9\u30a4\u30c4)\u3092\u4f7f\u7528\u3057\u306620\u500d\u306e\u500d\u7387\u3067\u86cd\u5149\u9855\u5fae\u93e1\u5199\u771f\u3092\u64ae\u5f71\u3057\u305f\u3002<\/p>\n<\/div>\n<div id=\"s2-8\" class=\"sec\">\n<h3 id=\"s2-8title\">\u514d\u75ab\u86cd\u5149<\/h3>\n<p class=\"p p-first-last\">\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5c40\u5728\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306b\u3001\u30ab\u30d0\u30fc\u30b9\u30ea\u30c3\u30d7\u4e0a\u3067\u5897\u6b96\u3055\u305b\u305f\u7d30\u80de\u3092\u51b7PBS\u3067\u6d17\u6d44\u3057\u30014%\u30d1\u30e9\u30db\u30eb\u30e0\u30a2\u30eb\u30c7\u30d2\u30c9\u306715\u5206\u9593\u56fa\u5b9a\u3057\u307e\u3057\u305f\u3002\u6b21\u306b\u3001\u7d30\u80de\u30920.5% Triton X-100\u306720\u5206\u9593\u900f\u904e\u51e6\u7406\u3057\u30015%\u30e4\u30ae\u8840\u6e05\u306730\u5206\u9593\u30d6\u30ed\u30c3\u30af\u3057\u305f\u3002\u7d30\u80de\u3092\u4e00\u6b21\u6297\u4f53\u3068\u3068\u3082\u306b4\u2103\u3067\u4e00\u6669\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30c8\u3057\u3001\u4e8c\u6b21\u6297\u4f53\u3068\u3068\u3082\u306b1\u6642\u9593\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30c8\u3057\u307e\u3057\u305f\u3002 3 \u56de\u6d17\u6d44\u3057\u305f\u5f8c\u3001\u7d30\u80de\u3092 4&#039;-6-\u30b8\u30a2\u30df\u30b8\u30ce-2-\u30d5\u30a7\u30cb\u30eb\u30a4\u30f3\u30c9\u30fc\u30eb (DAPI) \u3067\u67d3\u8272\u3057\u3001\u5171\u7126\u70b9\u30ec\u30fc\u30b6\u30fc\u8d70\u67fb\u578b\u9855\u5fae\u93e1\u3067\u753b\u50cf\u5316\u3057\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n<div id=\"s2-9\" class=\"sec\">\n<h3 id=\"s2-9title\">ATP\u6e2c\u5b9a<\/h3>\n<p class=\"p p-first-last\">\u3055\u3089\u306b\u3001\u7d30\u80de\u5185 ATP \u6fc3\u5ea6\u306f\u3001\u88fd\u9020\u5143\u306e\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u306b\u5f93\u3063\u3066 ATP \u30a2\u30c3\u30bb\u30a4 \u30ad\u30c3\u30c8\u3092\u4f7f\u7528\u3057\u3066\u6e2c\u5b9a\u3057\u307e\u3057\u305f\u3002\u30d4\u30da\u30c3\u30c6\u30a3\u30f3\u30b0\u3092\u7e70\u308a\u8fd4\u3057\u3066\u7d30\u80de\u3092\u6eb6\u89e3\u30d0\u30c3\u30d5\u30a1\u30fc\u306b\u6eb6\u89e3\u3057\u30014\u2103\u300113,000g\u306710\u5206\u9593\u9060\u5fc3\u5206\u96e2\u3057\u307e\u3057\u305f\u3002\u4e0a\u6e05\u306fATP\u30ec\u30d9\u30eb\u306e\u5206\u6790\u306b\u4f7f\u7528\u3055\u308c\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u6fc3\u5ea6\u306fBCA\u30a2\u30c3\u30bb\u30a4\u306b\u3088\u3063\u3066\u6e2c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002 \uff15\uff10\u03bc\uff4c\u306e\u4e0a\u6e05\u3092\uff11\uff10\uff10\u03bc\uff4c\u306e\uff21\uff34\uff30\u691c\u51fa\u6eb6\u6db2\u306b\u6dfb\u52a0\u3057\u3001\u5ba4\u6e29\u3067\uff15\u5206\u9593\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30c8\u3057\u3001\u76f4\u3061\u306b\u6df7\u5408\u3057\u3001\u30eb\u30df\u30ce\u30e1\u30fc\u30bf\u30fc\uff08\uff26\uff4c\uff45\uff58 \uff33\uff54\uff41\uff54\uff49\uff4f\uff4e \uff13\uff09\u3092\u4f7f\u7528\u3057\u3066\u767a\u5149\u3092\u6e2c\u5b9a\u3057\u305f\u3002 ATP\u306e\u6fc3\u5ea6\u3092\u6a19\u6e96\u66f2\u7dda\u306b\u5f93\u3063\u3066\u8a08\u7b97\u3057\u3001nmol\/\u03bcg\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u5909\u63db\u3057\u305f\u3002<\/p>\n<\/div>\n<div id=\"s2-10\" class=\"sec\">\n<h3 id=\"s2-10title\">\u30a6\u30a7\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c6\u30a3\u30f3\u30b0<\/h3>\n<p class=\"p p-first-last\">\u30bf\u30f3\u30d1\u30af\u8cea\u767a\u73fe\u306f\u30a6\u30a7\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c6\u30a3\u30f3\u30b0\u306b\u3088\u3063\u3066\u8a55\u4fa1\u3055\u308c\u3001\u30c7\u30f3\u30b7\u30c8\u30e1\u30c8\u30ea\u30fc\u306b\u3088\u3063\u3066\u5b9a\u91cf\u3055\u308c\u307e\u3057\u305f\u3002 10 cm \u7d30\u80de\u57f9\u990a\u76bf\u5185\u306e Dox \u304a\u3088\u3073 Dox + Brev \u51e6\u7406 H9c2 \u7d30\u80de\u3092 RIPA \u6eb6\u89e3\u30d0\u30c3\u30d5\u30a1\u30fc\u3067\u6eb6\u89e3\u3057\u307e\u3057\u305f\u3002 5 mg \u306e\u7d44\u7e54\u3092\u63a1\u53d6\u3057\u300110 ml \u306e\u6eb6\u89e3\u30d0\u30c3\u30d5\u30a1\u30fc\u3092\u52a0\u3048\u307e\u3059\u3002\u30d6\u30e9\u30c3\u30c9\u30d5\u30a9\u30fc\u30c9\u6cd5\u3092\u4f7f\u7528\u3057\u3066\u3001BSA\u3092\u6a19\u6e96\u3068\u3057\u3066\u5229\u7528\u3057\u3066\u30bf\u30f3\u30d1\u30af\u8cea\u6fc3\u5ea6\u3092\u6e2c\u5b9a\u3057\u305f\u3002\u7b49\u91cf\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30ed\u30fc\u30c7\u30a3\u30f3\u30b0\u30d0\u30c3\u30d5\u30a1\u30fc\uff085X\uff09\u3068\u6df7\u5408\u3057\u300195\u2103\u30675\u5206\u9593\u716e\u6cb8\u3057\u307e\u3057\u305f\u3002\u6b21\u306b\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3092 10%-12% SDS-\u30dd\u30ea\u30a2\u30af\u30ea\u30eb\u30a2\u30df\u30c9\u30b2\u30eb (SDS-PAGE) \u3067\u306e\u96fb\u6c17\u6cf3\u52d5\u306b\u3088\u3063\u3066\u5206\u96e2\u3057\u3001PVDF \u30e1\u30f3\u30d6\u30ec\u30f3\u306b\u8ee2\u5199\u3057\u307e\u3057\u305f\u3002 TBST\u4e2d\u306e5%\u30df\u30eb\u30af\u3067\u5ba4\u6e29\u30672\u6642\u9593\u30d6\u30ed\u30c3\u30ad\u30f3\u30b0\u3057\u305f\u5f8c\u3001\u819c\u3092\u30a6\u30b5\u30ae\u30dd\u30ea\u30af\u30ed\u30fc\u30ca\u30ebGAPDH\u306a\u3069\u306e\u7279\u7570\u7684\u6297\u4f53\u3068\u3068\u3082\u306b4\u2103\u3067\u4e00\u6669\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30c8\u3057\u307e\u3057\u305f\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u767a\u73fe\u304a\u3088\u3073\u30ea\u30f3\u9178\u5316\u306e WB \u5206\u6790\u306f\u3001AMPK\u3001Parkin\u3001PINK1\u3001Akt\u3001PI3K\u3001Tom20 \u306b\u5bfe\u3059\u308b\u6297\u4f53\u3092\u4f7f\u7528\u3057\u3066\u5b9f\u884c\u3055\u308c\u3001GAPDH \u304c\u5185\u90e8\u5bfe\u7167\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u3002\u7279\u5b9a\u306e\u30b7\u30b0\u30ca\u30eb\u306f\u3001Bio-Rad gel doc \u30b7\u30b9\u30c6\u30e0 (Bio-Rad Laboratories\u3001\u30ab\u30ea\u30d5\u30a9\u30eb\u30cb\u30a2\u3001\u7c73\u56fd) \u3092\u4f7f\u7528\u3057\u3066\u8996\u899a\u5316\u3055\u308c\u307e\u3057\u305f\u3002\u30c7\u30fc\u30bf\u306f\u5e73\u5747\u5024 \u00b1 SD (<em>n<\/em>\u00a0= 3)\u3001ImageJ \u5206\u6790\u306b\u3088\u3063\u3066\u5b9a\u91cf\u5316\u3055\u308c\u307e\u3059\u3002<\/p>\n<\/div>\n<div id=\"s2-11\" class=\"sec\">\n<h3 id=\"s2-11title\">\u755c\u7523<\/h3>\n<p class=\"p p-first\">\u5b9f\u9a13\u306b\u306f\u751f\u5f8c 8 \u9031\u9f62\u306e\u96cc C57BL\/6 \u30de\u30a6\u30b9 (SiPeiFu\u3001\u5317\u4eac\u3001\u4e2d\u56fd) \u3092\u4f7f\u7528\u3057\u307e\u3057\u305f\u3002\u52d5\u7269\u306f\u30b1\u30fc\u30b8\u306b\u5165\u308c\u3001\u6e7f\u5ea6 50\u00b1TP3T\u300125\u2103\u00b12\u2103\u3067 12 \u6642\u9593\u660e\/12 \u6642\u9593\u6697\u30b5\u30a4\u30af\u30eb\u3067\u98fc\u80b2\u3057\u307e\u3057\u305f\u3002\u52d5\u7269\u306b\u306f\u6a19\u6e96\u7684\u306a\u30da\u30ec\u30c3\u30c8\u98df\u3068\u6c34\u3092\u81ea\u7531\u306b\u6442\u53d6\u3055\u305b\u305f\u3002 4\u2103\u3001200g\u306710\u5206\u9593\u306e\u9060\u5fc3\u5206\u96e2\u306b\u3088\u3063\u3066\u8840\u6f3f\u3092\u5f97\u3001\u62bd\u51fa\u524d\u306b-80\u2103\u306b\u4fdd\u3063\u305f\u3002<\/p>\n<p class=\"p p-last\">\u8abf\u67fb\u306f\u4ee5\u4e0b\u306b\u6e96\u62e0\u3057\u3066\u3044\u307e\u3059\u3002\u00a0<em>\u5b9f\u9a13\u52d5\u7269\u306e\u7ba1\u7406\u3068\u4f7f\u7528\u306b\u95a2\u3059\u308b\u30ac\u30a4\u30c9<\/em>\u00a0\u7c73\u56fd\u56fd\u7acb\u885b\u751f\u7814\u7a76\u6240\u306b\u3088\u3063\u3066\u767a\u884c\u3055\u308c\u307e\u3057\u305f (NIH Publication No. 85\u201323\u30011985 \u5e74\u6539\u8a02)\u3002<\/p>\n<\/div>\n<div id=\"s2-12\" class=\"sec\">\n<h3 id=\"s2-12title\">\u52d5\u7269\u5b9f\u9a13\u30d7\u30ed\u30c8\u30b3\u30eb<\/h3>\n<p class=\"p p-first\">\u30de\u30a6\u30b9\u306f\u3001\u5bfe\u7167\u7fa4\u3001\u30e2\u30c7\u30eb\u7fa4\uff08Dox \u7fa4\uff09\u30013 \u7528\u91cf\u306e Dox + Brev \u7fa4\u3001\u304a\u3088\u3073 Dox + Dexra \u7fa4\u3092\u542b\u3080 6 \u3064\u306e\u6cbb\u7642\u7fa4\u306b\u30e9\u30f3\u30c0\u30e0\u306b\u5272\u308a\u5f53\u3066\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u4eba\u9593\u306e\u6cbb\u7642\u8a08\u753b\u3092\u6a21\u5023\u3059\u308b\u305f\u3081\u306b\u3001\u7d2f\u7a4d\u7528\u91cf 12 mg\/kg \u306e Dox \u304c\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002\u00a0<em>\u7d4c\u7531<\/em>\u00a0\u5bfe\u7167\u7fa4\u3092\u9664\u3044\u3066\u3001\u6bce\u9031\uff13\u56de\u306e\u8179\u8154\u5185\u6ce8\u5c04\uff08\uff10\u65e5\u76ee\u3001\uff17\u65e5\u76ee\u3001\u304a\u3088\u3073\uff11\uff14\u65e5\u76ee\u306b\uff14\uff4d\uff47\uff0f\uff4b\uff47\uff09\u3002<\/p>\n<p>Brev \u306e\u52b9\u679c\u3092\u8abf\u67fb\u3059\u308b\u306b\u306f\u00a0<em>\u751f\u4f53\u5185\u3067\u306f\u3001<\/em>\u00a0\u30de\u30a6\u30b9\u3092Brev\u3067\u6cbb\u7642\u3057\u3001\u7d9a\u3044\u3066\u6bce\u65e54.8mg\/kg\u304a\u3088\u307316mg\/kg\u306eBrev\u30923\u9031\u9593\u8179\u8154\u5185\u6ce8\u5c04\u3057\u3001Dox+Dexra\u6cbb\u7642\u7fa4\u306e\u30de\u30a6\u30b9\u306b\u306fDox\u306b\u52a0\u3048\u306612mg\/kg\u306eDexra\u30923\u9031\u9593\u8179\u8154\u5185\u6ce8\u5c04\u3057\u305f\u3002\u51e6\u7406\u3002 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B1\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30a2\u30ec\u30af\u30b5\u30f3\u30c9\u30eb\u4ed6\u30012020<\/a>\uff09\u3002\u30d6\u30ec\u30d6\u3068\u30c7\u30af\u30b9\u30e9\u306fDox\u6ce8\u5c04\u5f8c\u306b\u6cbb\u7642\u3092\u53d7\u3051\u305f\u3002 Dox \u306e\u6700\u521d\u306e\u6ce8\u5c04\u304b\u3089 3 \u9031\u9593\u5f8c\u306b\u3001\u751f\u5b58\u7387\u3092\u6bce\u65e5\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3057\u3001\u5fc3\u30a8\u30b3\u30fc\u691c\u67fb\u306b\u3088\u3063\u3066\u5fc3\u81d3\u6a5f\u80fd\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B21\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ea\u30fc\u3089\u30012018<\/a>).<\/p>\n<p class=\"p p-last\">\u5bfe\u7167\u7fa4\u306b\u306f\u540c\u91cf\u306e\u751f\u7406\u98df\u5869\u6c34\u3092\u6ce8\u5c04\u3057\u305f\u3002 Dox\u6295\u4e0e\u306e1\u9031\u9593\u5f8c\u306b\u30de\u30a6\u30b9\u3092\u5c60\u6bba\u3057\u305f\u3002<\/p>\n<\/div>\n<div id=\"s2-13\" class=\"sec\">\n<h3 id=\"s2-13title\">\u816b\u760d\u7814\u7a76<\/h3>\n<p class=\"p p-first-last\">\u30de\u30a6\u30b9\u306b1\u00d710 \u3092\u76ae\u4e0b\u6ce8\u5c04\u3057\u305f\u3002<sup>5<\/sup>\u00a04T1 \u4e73\u623f\u816b\u760d\u7d30\u80de\u3002\u7d30\u80de\u6ce8\u5c04\u306e 1 \u9031\u9593\u5f8c\u3001\u816b\u760d\u306e\u5e73\u5747\u76f4\u5f84\u304c 2 mm \u3092\u8d85\u3048\u305f\u3068\u304d\u3001\u30de\u30a6\u30b9\u3092\u524d\u8ff0\u306e\u3088\u3046\u306b Dox \u307e\u305f\u306f\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u3067\u6cbb\u7642\u3057\u307e\u3057\u305f\u3002\u816b\u760d\u30b5\u30a4\u30ba\u306f\u9031\u306b 2 \u56de\u3001\u6700\u5927 4 \u9031\u9593\u6e2c\u5b9a\u3055\u308c\u3001\u816b\u760d\u4f53\u7a4d\u306f\u6b21\u306e\u5f0f\u3067\u8a08\u7b97\u3055\u308c\u307e\u3057\u305f: V = 4\u03c0\/3\u00d7(L\/2)2\u00d7(W\/2)\u3001\u3053\u3053\u3067\u3001V\u3001L\u3001\u304a\u3088\u3073 W \u306f\u6b21\u306e\u5f0f\u3092\u8868\u3057\u307e\u3059\u3002\u305d\u308c\u305e\u308c\u816b\u760d\u306e\u4f53\u7a4d\u3001\u9577\u3055\u3001\u5e45\u3002<\/p>\n<\/div>\n<div id=\"s2-14\" class=\"sec\">\n<h3 id=\"s2-14title\"><sup>18<\/sup>F-\u30d5\u30eb\u30aa\u30ed\u30c7\u30aa\u30ad\u30b7\u30b0\u30eb\u30b3\u30fc\u30b9 PET\/CT \u30a4\u30e1\u30fc\u30b8\u30f3\u30b0<\/h3>\n<p class=\"p p-first-last\">Dox \u304a\u3088\u3073\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u7fa4\u306e\u30de\u30a6\u30b9 (\u4e00\u6669\u7d76\u98df) \u3092 2% \u30a4\u30bd\u30d5\u30eb\u30e9\u30f3\u3067\u9ebb\u9154\u3057\u3001\u7d04 11MBq\/0.2 ml \u306e\u30d5\u30eb\u30aa\u30ed\u30c7\u30aa\u30ad\u30b7\u30b0\u30eb\u30b3\u30fc\u30b9 (FDG) PET \u3092\u6ce8\u5c04\u3057\u307e\u3057\u305f\u3002\u00a0<em>\u7d4c\u7531<\/em>\u00a0\u5c3e\u9759\u8108\u3092\u63a1\u53d6\u3057\u3001\u30b1\u30fc\u30b8\u306b\u623b\u3057\u307e\u3057\u305f\u3002 40\u5206\u5f8c\u3001\u30de\u30a6\u30b9\u30922%\u30a4\u30bd\u30d5\u30eb\u30e9\u30f3\u3067\u518d\u5ea6\u9ebb\u9154\u3057\u3001microPET Focus 220\uff08Siemens Company\u3001\u30d9\u30eb\u30ea\u30f3\u3001\u30c9\u30a4\u30c4\uff09\u306e\u5b9a\u4f4d\u30d9\u30c3\u30c9\u4e0a\u306b\u7f6e\u3044\u305f\u3002\u6b21\u306b\u300120 \u5206\u9593\u306e\u9759\u7684 PET \u30b9\u30ad\u30e3\u30f3\u304c\u958b\u59cb\u3055\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\u3001\u30de\u30a6\u30b9\u306f\u3001PET \u753b\u50cf\u3068\u306e\u89e3\u5256\u5b66\u7684\u4f4d\u7f6e\u5408\u308f\u305b\u306e\u305f\u3081\u306b\u3001microCAT II (Siemens Company\u3001\u30d9\u30eb\u30ea\u30f3\u3001\u30c9\u30a4\u30c4) \u3067 X \u7dda\u30d3\u30fc\u30e0\u5f37\u5ea6 180 mAs\u3001X \u7dda\u7ba1\u96fb\u5727 80 kVp \u3067\u753b\u50cf\u5316\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n<div id=\"s2-15\" class=\"sec\">\n<h3 id=\"s2-15title\">\u60a3\u8005<\/h3>\n<p class=\"p p-first-last\">4 \u6642\u9593\u4ee5\u4e0a\u7d76\u98df\u3057\u3001\u8840\u7cd6\u5024\u304c 120 mg\/dl \u672a\u6e80\u3067\u3042\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u305f\u5f8c\u3001\u3059\u3079\u3066\u306e\u60a3\u8005\u306b\u6b21\u306e\u85ac\u7269\u306e\u9759\u8108\u5185\u6295\u4e0e\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u00a0<sup>18<\/sup>F-FDG (5.5 MBq\/kg)\u3002 \uff30\uff25\uff34\uff0f\uff23\uff34\u30b9\u30ad\u30e3\u30f3\u306f\u3001\u8907\u5408\uff30\uff25\uff34\uff0f\uff23\uff34\u30d0\u30a4\u30aa\u30b0\u30e9\u30d5\uff08\uff33\uff49\uff45\uff4d\uff45\uff4e\uff53 \uff23\uff4f\uff4d\uff50\uff41\uff4e\uff59\u3001\u30d9\u30eb\u30ea\u30f3\u3001\u30c9\u30a4\u30c4\uff09\u3092\u4f7f\u7528\u3057\u3066\u3001\u6ce8\u5c04\u306e\uff16\uff10\u5206\u5f8c\u306b\u958b\u59cb\u3057\u305f\u3002\u3059\u3079\u3066\u306e\u30b9\u30ad\u30e3\u30f3\u306f 3 \u6b21\u5143\u30e2\u30c7\u30eb\u3067\u5b9f\u884c\u3055\u308c\u307e\u3057\u305f\u3002\u6e1b\u8870\u88dc\u6b63\u3068\u89e3\u5256\u5b66\u7684\u76f8\u95a2\u95a2\u4fc2\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u3001\u307e\u305a\u4f4e\u7dda\u91cf CT \u30b9\u30ad\u30e3\u30f3\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u502b\u7406\u7684\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u306f\u3001\u9752\u5cf6\u5927\u5b66\u9644\u5c5e\u75c5\u9662\u767a\u884c\u306e\u502b\u7406\u59d4\u54e1\u4f1a\u627f\u8a8d\u6587\u66f8\u30ac\u30a4\u30c9\uff08QDU-HEC-2022057\uff09\u306b\u6e96\u62e0\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n<div id=\"s2-16\" class=\"sec\">\n<h3 id=\"s2-16title\">\u5fc3\u6a5f\u80fd\u304a\u3088\u3073\u75c5\u7406\u7d44\u7e54\u5b66\u306e\u5206\u6790<\/h3>\n<p class=\"p p-first-last\">\u5404\u30b0\u30eb\u30fc\u30d7\u306e\u30de\u30a6\u30b9\u5fc3\u81d3\u7d44\u7e54\u3092 4% \u30d1\u30e9\u30db\u30eb\u30e0\u30a2\u30eb\u30c7\u30d2\u30c9\u4e2d\u306b\u4fdd\u5b58\u3057\u3001\u30d1\u30e9\u30d5\u30a3\u30f3\u30ef\u30c3\u30af\u30b9\u306b\u5305\u57cb\u3057\u30014 mm \u5207\u7247\u306b\u9023\u7d9a\u7684\u306b\u5207\u65ad\u3057\u307e\u3057\u305f\u3002\u7d44\u7e54\u5207\u7247\u3092\u8131\u30d1\u30e9\u30d5\u30a3\u30f3\u3057\u305f\u00a0<em>\u7d4c\u7531<\/em>\u00a0\u30ad\u30b7\u30ec\u30f3\u306b\u6d78\u6f2c\u3057\uff083 \u56de\u3001\u5404 5 \u5206\u9593\uff09\u3001\u964d\u9806\u306e\u4e00\u9023\u306e\u30a2\u30eb\u30b3\u30fc\u30eb\u3092\u4f7f\u7528\u3057\u3066\u518d\u6c34\u548c\u3057\u307e\u3057\u305f\uff08100%\u300190%\u300185%\u3001\u304a\u3088\u3073 75% \u30a2\u30eb\u30b3\u30fc\u30eb\u3001\u5404 5 \u5206\u9593\uff09\u3002\u7d44\u7e54\u5b66\u7684\u5206\u6790\u306e\u305f\u3081\u306b\u3001\u5207\u7247\u3092\u30d8\u30de\u30c8\u30ad\u30b7\u30ea\u30f3\u304a\u3088\u3073\u30a8\u30aa\u30b7\u30f3\u3067\u67d3\u8272\u3057\u305f\u3002\u751f\u691c\u30b5\u30f3\u30d7\u30eb\u306f\u3001\u5fc3\u81d3\u306e\u5f62\u614b\u5b66\u7684\u5909\u5316\u304a\u3088\u3073\u7dda\u7dad\u6027\u5909\u5316\u3092\u8abf\u67fb\u3059\u308b\u305f\u3081\u306b\u3001\u30de\u30c3\u30bd\u30f3\u30c8\u30ea\u30af\u30ed\u30fc\u30e0\u67d3\u8272\u3092\u4f7f\u7528\u3057\u3066\u67d3\u8272\u3055\u308c\u307e\u3057\u305f\u3002\u9752\u8272\u306e\u67d3\u8272\u306f\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u84c4\u7a4d\u3092\u8868\u3057\u307e\u3057\u305f\u3002\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u306f\u3001\u30d2\u30b9\u30c8\u30f3\u5358\u7d14\u67d3\u8272\u30ad\u30c3\u30c8 (\u30cb\u30c1\u30ec\u30a4\u3001\u6771\u4eac\u3001\u65e5\u672c) \u3092\u88fd\u9020\u8005\u306e\u6307\u793a\u306b\u5f93\u3063\u3066\u4f7f\u7528\u3057\u3066\u5b9f\u65bd\u3057\u307e\u3057\u305f\u3002\u5207\u7247\u3092\u30e1\u30bf\u30ce\u30fc\u30eb\u4e2d\u306e 3% H2O2 \u3067 15 \u5206\u9593\u51e6\u7406\u3057\u3066\u5185\u56e0\u6027\u30da\u30eb\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc\u3092\u4e0d\u6d3b\u6027\u5316\u3057\u3001\u6b21\u306b\u4e00\u6b21\u6297\u4f53 IL-1 (1:100) \u3068\u3068\u3082\u306b\u5ba4\u6e29\u3067 1 \u6642\u9593\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30c8\u3057\u307e\u3057\u305f\u3002\u6b21\u3044\u3067\u3001\uff2c\uff45\uff49\uff43\uff41 \uff2d\uff49\uff43\uff52\uff4f\uff53\uff59\uff53\uff54\uff45\uff4d\uff53\u306e\uff23\uff2d\uff33 \uff27\uff4d\uff42\uff28\u5012\u7acb\u86cd\u5149\u9855\u5fae\u93e1\uff08\uff2c\uff45\uff49\uff43\uff41 \uff23\uff41\uff4d\uff45\uff52\uff41 \uff21\uff27\u3001\uff22\uff41\uff52\uff4e\uff41\uff43\uff4b\u3001\uff27\uff45\uff52\uff4d\uff41\uff4e\uff59\uff09\u3092\u4f7f\u7528\u3057\u3066\u8d85\u5fae\u7d30\u69cb\u9020\u3092\uff12\uff10\u500d\u306e\u500d\u7387\u3067\u89b3\u5bdf\u3057\u305f\u3002<\/p>\n<\/div>\n<div id=\"s2-17\" class=\"sec\">\n<h3 id=\"s2-17title\">\u8840\u7cd6\u5024\u306e\u6e2c\u5b9a<\/h3>\n<p class=\"p p-first\">\u30de\u30a6\u30b9\u306b\u306f\u901a\u5e38\u306e\u56fa\u5f62\u98fc\u6599\u3092\u4e0e\u3048\u3066\u98fc\u80b2\u3057\u305f\u3002\u5b9f\u9a13\u5f53\u65e5\u3001\u30de\u30a6\u30b9\u30926\u6642\u9593(\u5348\u524d8\u6642\u304b\u3089)\u7d76\u98df\u3055\u305b\u3001\u8840\u6db2\u3092\u63a1\u53d6\u3057\u305f\u3002\u00a0<em>\u7d4c\u7531<\/em>\u00a0\u8840\u7cd6\u5024\u306e\u6e2c\u5b9a\u306b\u306f\u5c3e\u9759\u8108\u3092\u4f7f\u7528\u3057\u307e\u3059\u3002<\/p>\n<p class=\"p p-last\">H9c2 \u30e9\u30c3\u30c8\u5fc3\u7b4b\u82bd\u7d30\u80de\u3092\u30ea\u30f3\u9178\u7de9\u885d\u751f\u7406\u98df\u5869\u6c34 (PBS) \u3067\u6d17\u6d44\u3057\u3001\u9060\u5fc3\u5206\u96e2\u3057\u3066\u8d85\u97f3\u6ce2\u7834\u7815\u3057\u3001\u6a19\u6e96\u7684\u306a\u7d30\u80de\u57f9\u990a\u6761\u4ef6\u4e0b\u3067 10 \u5206\u9593\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30c8\u3057\u307e\u3057\u305f\u3002\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30b7\u30e7\u30f3\u5f8c\u3001\u30de\u30a4\u30af\u30ed\u30d7\u30ec\u30fc\u30c8\u30ea\u30fc\u30c0\u30fc\uff08Perkin Elmer\u3001\u7c73\u56fd\u30de\u30b5\u30c1\u30e5\u30fc\u30bb\u30c3\u30c4\u5dde\uff09\u3092\u4f7f\u7528\u3057\u3066\u5438\u5149\u5ea6\u3092\u6e2c\u5b9a\u3057\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n<div id=\"s2-18\" class=\"sec\">\n<h3 id=\"s2-18title\">\u9175\u7d20\u514d\u75ab\u6e2c\u5b9a\u6cd5<\/h3>\n<p class=\"p p-first-last\">\u30de\u30a6\u30b9\u7d44\u7e54\u3092\u6eb6\u89e3\u30d0\u30c3\u30d5\u30a1\u30fc\u3067\u6eb6\u89e3\u3057\u307e\u3057\u305f\u3002\u30b5\u30f3\u30d7\u30eb\u3092 Qsonica \u30db\u30e2\u30b8\u30ca\u30a4\u30b6\u30fc\u3067 30 Hz \u30d1\u30eb\u30b9\u3092\u4f7f\u7528\u3057\u3066 20 \u79d2\u9593\u8d85\u97f3\u6ce2\u51e6\u7406\u3057\u3001\u305d\u306e\u5f8c 12,000 g \u3067 10 \u5206\u9593\u9060\u5fc3\u5206\u96e2\u3057\u307e\u3057\u305f\u3002\u4e0a\u6e05\u3092\u53ce\u96c6\u3057\u3001200 \u03bcl \u30d0\u30a4\u30a2\u30eb\u306b\u7b49\u5206\u3057\u3001-80\u00b0C \u3067\u4fdd\u5b58\u3057\u307e\u3057\u305f\u3002\u30b5\u30f3\u30d7\u30eb\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u6fc3\u5ea6\u306fBCA\u30a2\u30c3\u30bb\u30a4\u306b\u3088\u3063\u3066\u5b9a\u91cf\u3055\u308c\u307e\u3057\u305f\u3002\u30e1\u30fc\u30ab\u30fc\u306e\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u306b\u5f93\u3063\u3066\u3001TNF-\u03b1\u3001IL-1\u03b2\u3001\u304a\u3088\u3073IL-6\u306e\u9175\u7d20\u7d50\u5408\u514d\u75ab\u5438\u7740\u30a2\u30c3\u30bb\u30a4\u30ad\u30c3\u30c8\u3092\u4f7f\u7528\u3057\u3066\u30b5\u30f3\u30d7\u30eb\u3092\u5206\u6790\u3057\u307e\u3057\u305f\u3002\u5149\u5b66\u5bc6\u5ea6\u306f\u3001\uff36\uff29\uff23\uff34\uff2f\uff32 \uff2e\uff49\uff56\uff4f\uff08\u5546\u6a19\uff09\u30de\u30a4\u30af\u30ed\u30d7\u30ec\u30fc\u30c8\u30ea\u30fc\u30c0\u30fc\uff08\uff30\uff45\uff52\uff4b\uff49\uff4e \uff25\uff4c\uff4d\uff45\uff52\u3001\u30de\u30b5\u30c1\u30e5\u30fc\u30bb\u30c3\u30c4\u5dde\u3001\u7c73\u56fd\uff09\u3092\u4f7f\u7528\u3057\u3066\uff14\uff15\uff10\uff4e\uff4d\u3067\u6e2c\u5b9a\u3057\u305f\u3002<\/p>\n<\/div>\n<div id=\"s2-19\" class=\"sec\">\n<h3 id=\"s2-19title\">\u30de\u30a6\u30b9\u306e\u30e1\u30bf\u30dc\u30ed\u30fc\u30e0\u5909\u5316\u306e\u6e2c\u5b9a<\/h3>\n<p class=\"p p-first-last\">\u8840\u6db2\u30b5\u30f3\u30d7\u30eb\u3092\u518d\u61f8\u6fc1\u3057\u3001\u6c37\u4e0a\u3067\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30c8\u3057\u3001\u9060\u5fc3\u5206\u96e2\u3057\u3001\u6700\u7d42\u6fc3\u5ea6\u307e\u3067\u5e0c\u91c8\u3057\u3001\u9060\u5fc3\u5206\u96e2\u3057\u307e\u3057\u305f\u3002\u6700\u5f8c\u306b\u3001\u4e0a\u6e05\u3092\u5206\u6790\u306e\u305f\u3081\u306b LC-MS\/MS \u30b7\u30b9\u30c6\u30e0\u306b\u6ce8\u5165\u3057\u307e\u3057\u305f\u3002 UHPLC-MS\/MS \u5206\u6790\u306f\u3001Orbitrap Q Exactive \u3068\u7d44\u307f\u5408\u308f\u305b\u305f Vanquish UHPLC \u30b7\u30b9\u30c6\u30e0 (Thermo Fisher\u3001\u30de\u30b5\u30c1\u30e5\u30fc\u30bb\u30c3\u30c4\u5dde\u3001\u7c73\u56fd) \u3092\u4f7f\u7528\u3057\u3066\u5b9f\u884c\u3055\u308c\u307e\u3057\u305f\u3002<sup>TM<\/sup>\u00a0HF \u8cea\u91cf\u5206\u6790\u8a08 (Thermo Fisher\u3001\u30de\u30b5\u30c1\u30e5\u30fc\u30bb\u30c3\u30c4\u5dde\u3001\u7c73\u56fd)\u3002\u540c\u5b9a\u3055\u308c\u305f\u4ee3\u8b1d\u7269\u306b\u306f\u3001KEGG \u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3001HMDB \u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3001\u304a\u3088\u3073 LIPID Maps \u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u4f7f\u7528\u3057\u3066\u6ce8\u91c8\u304c\u4ed8\u3051\u3089\u308c\u307e\u3057\u305f\u3002\u4e3b\u6210\u5206\u5206\u6790 (PCA) \u3068\u90e8\u5206\u6700\u5c0f\u4e8c\u4e57\u5224\u5225\u5206\u6790 (PLS-DA) \u306f\u3001metaX \u3092\u4f7f\u7528\u3057\u3066\u5b9f\u884c\u3055\u308c\u307e\u3057\u305f\u3002\u5358\u5909\u91cf\u89e3\u6790\u3092\u9069\u7528\u3057\u307e\u3057\u305f (<em>t<\/em>-test) \u7d71\u8a08\u7684\u6709\u610f\u6027 (<em>p<\/em>-\u4fa1\u5024\uff09\u3002 VIP&gt;1 \u306e\u4ee3\u8b1d\u7269\u3001\u00a0<em>p<\/em>\u00a0\u5024 &lt; 0.05\u3001\u304a\u3088\u3073\u500d\u7387\u5909\u5316 \u22652 \u307e\u305f\u306f \u22640.5 \u306f\u3001\u5dee\u6b21\u7684\u306b\u8c4a\u5bcc\u306a\u4ee3\u8b1d\u7523\u7269\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n<div id=\"s2-20\" class=\"sec sec-last\">\n<h3 id=\"s2-20title\">\u7d71\u8a08\u5206\u6790<\/h3>\n<p class=\"p p-first-last\">\u7d71\u8a08\u5206\u6790\u306f\u3001IBM SPSS Statistics (V19.0\u3001\u30a2\u30e1\u30ea\u30ab) \u306b\u3088\u308b ANOVA \u3092\u4f7f\u7528\u3057\u3066\u5b9f\u884c\u3055\u308c\u307e\u3057\u305f\u3002\u30c7\u30fc\u30bf\u306f\u5e73\u5747\u5024 \u00b1 SD (<em>n<\/em>\u00a0= 6\u20139)\u3002\u00a0<em>p<\/em>\u00a0&lt; 0.05 \u306f\u6709\u610f\u3067\u3042\u308b\u3068\u307f\u306a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n<\/div>\n<div id=\"s3\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"s3title\" class=\"head no_bottom_margin ui-helper-clearfix\">\u7d50\u679c<\/h2>\n<div id=\"s3-1\" class=\"sec sec-first\">\n<h3 id=\"s3-1title\">\u30a2\u30f3\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u306f\u5fc3\u7b4b\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u8102\u80aa\u9178\u306e\u5229\u7528\u3092\u5897\u52a0\u3055\u305b\u307e\u3059\u3002<\/h3>\n<p class=\"p p-first\">\u79c1\u305f\u3061\u306f\u6700\u521d\u306b\u52c9\u5f37\u3057\u307e\u3057\u305f\u00a0<sup>18<\/sup>\u30a2\u30f3\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u7cfb\u5316\u5b66\u7642\u6cd5\u3092\u53d7\u3051\u305f\u60a3\u8005\u3068\u5316\u5b66\u7642\u6cd5\u3092\u53d7\u3051\u306a\u304b\u3063\u305f\u60a3\u8005\u306e\u5fc3\u81d3\u306e F-FDG PET\/CT \u753b\u50cf\u3068\u30c7\u30fc\u30bf\u5206\u6790\u306b\u3088\u308a\u3001(<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F1\/\" target=\"figure\" rel=\"noopener\">\u56f31A<\/a>\uff09\u5316\u5b66\u7642\u6cd5\u3092\u53d7\u3051\u305f\u60a3\u8005\u3067\u306f\u5fc3\u7b4b\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u304c\u6e1b\u5c11\u3059\u308b\u50be\u5411\u304c\u3042\u308b\u3002\u6211\u3005\u306f\u3001\u3053\u306e\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u306e\u5909\u5316\u304c\u30a2\u30f3\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u8a98\u767a\u6027\u5fc3\u6bd2\u6027\u3068\u76f8\u95a2\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u4e88\u6e2c\u3057\u307e\u3057\u305f\u3002\u4ee3\u8b1d\u7570\u5e38\u3068 DIC \u306e\u9593\u306e\u672c\u8cea\u7684\u306a\u95a2\u9023\u6027\u3092\u691c\u8a3c\u3059\u308b\u305f\u3081\u306b\u3001\u6211\u3005\u306f Dox \u8a98\u767a DIC \u30de\u30a6\u30b9 \u30e2\u30c7\u30eb\u3092\u78ba\u7acb\u3057\u307e\u3057\u305f\u3002\u00a0<sup>18<\/sup>F-FDG PET\u306e\u7d50\u679c\u306f\u30014\u9031\u9593\u5f8c\u3001Dox\u6cbb\u7642\u30de\u30a6\u30b9\u306e\u5fc3\u81d3\u3078\u306e\u53d6\u308a\u8fbc\u307f\u304c\u672a\u6cbb\u7642\u30de\u30a6\u30b9\u3088\u308a\u3082\u6709\u610f\u306b\u4f4e\u3044\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F1\/\" target=\"figure\" rel=\"noopener\">\u56f31B<\/a>\uff09\u3002\u3053\u308c\u306f\u3001\u30a2\u30f3\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u304c\u60a3\u8005\u3068\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u306e\u4e21\u65b9\u3067\u5fc3\u7b4b\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<div id=\"F1\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm139983198938400\">\n<div class=\"ts_bar small\" title=\"\u753b\u50cf\u3092\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u3057\u307e\u3059\"><\/div>\n<p><a class=\"inline_block ts_canvas\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/core\/lw\/2.0\/html\/tileshop_pmc\/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&amp;p=PMC3&amp;id=9551275_fphar-13-930835-g001.jpg\" target=\"tileshopwindow\" rel=\"noopener\"><img decoding=\"async\" class=\"tileshop\" title=\"\u753b\u50cf\u3092\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u3057\u307e\u3059\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/bin\/fphar-13-930835-g001.jpg\" alt=\"An external file that holds a picture, illustration, etc.Object name is fphar-13-930835-g001.jpg\" \/><\/a><\/div>\n<div id=\"lgnd_F1\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F1\/\" target=\"figure\" rel=\"noopener\">\u56f31<\/a><\/div>\n<div class=\"caption\">\n<p><strong>(A)<\/strong>\u00a0\u306e\u6fc3\u5ea6\u00a0<sup>18<\/sup>F-FDG \u306f\u3001\u5316\u5b66\u7642\u6cd5\u3092\u53d7\u3051\u305f\u60a3\u8005\u3068\u53d7\u3051\u306a\u304b\u3063\u305f\u60a3\u8005\u306e\u5fc3\u81d3\u306b\u53d6\u308a\u8fbc\u307e\u308c\u307e\u3059\u3002\u00a0<strong>(B)<\/strong>\u00a0<sup>18<\/sup>F-FDG PET\/CT\u753b\u50cf\u53d6\u5f97\u3068\u5fc3\u81d3\u00a0<sup>18<\/sup>F-FDG\u306e\u53d6\u308a\u8fbc\u307f\u3002\u00a0<strong>(C)<\/strong>\u00a0Dox \u51e6\u7406\u30de\u30a6\u30b9\u306e\u30d2\u30fc\u30c8 \u30de\u30c3\u30d7\u3002\u00a0<strong>(D)<\/strong>\u00a0H9c2 \u7d30\u80de\u306e MDA \u542b\u6709\u91cf\u3002\u00a0<strong>(\u30db)<\/strong>\u00a0HE \u67d3\u8272\u306f\u3001Dox \u304c\u5fc3\u7b4b\u7d30\u80de\u306e\u30b5\u30a4\u30ba\u3092\u7e2e\u5c0f\u3057\u305f\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u5bfe Dox: ***<em>p<\/em>\u00a0&lt; 0.0005\u3001**<em>p<\/em>\u00a0&lt; 0.005\u3001*<em>p<\/em>\u00a0&lt; 0.05\u3001\u5e73\u5747\u00b1SD\u3002\u00a0<em>n<\/em>\u00a0= 6\u20139\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p class=\"p p-last\">\u901a\u5e38\u306e\u72b6\u614b\u3067\u306f\u3001\u5fc3\u7b4b\u306f\u30a8\u30cd\u30eb\u30ae\u30fc\u4f9b\u7d66\u306b\u4e3b\u306b\u7cd6\u3068\u8102\u8cea\u3092\u4f7f\u7528\u3057\u3001\u7cd6\u3068\u8102\u8cea\u306f\u305d\u308c\u305e\u308c\u5fc3\u7b4b\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u7d04 20% \uff5e 30% \u3068 60% \u3092\u5360\u3081\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u306fATP\u306e\u751f\u6210\u306b\u304a\u3044\u3066\u3088\u308a\u52b9\u7387\u7684\u3067\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B39\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30b7\u30e3\u30aa\u3068\u30c6\u30a3\u30a2\u30f3\u30012015<\/a>\uff09\u3002\u5316\u5b66\u7642\u6cd5\u4ecb\u5165\u306b\u3088\u308b\u5fc3\u7b4b\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306e\u518d\u5f62\u6210\u306b\u5fc3\u81d3\u304c\u3069\u306e\u3088\u3046\u306b\u9069\u5fdc\u3059\u308b\u306e\u304b\u3001\u307e\u305f\u305d\u306e\u3088\u3046\u306a\u5909\u5316\u304c\u5fc3\u81d3\u306e\u6052\u5e38\u6027\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3066DIC\u306e\u767a\u75c7\u306b\u3064\u306a\u304c\u308b\u306e\u304b\u3069\u3046\u304b\u306f\u4e0d\u660e\u3067\u3042\u308b\u3002\u30de\u30a6\u30b9\u306e\u30e1\u30bf\u30dc\u30ed\u30fc\u30e0\u30c7\u30fc\u30bf\u3092\u5206\u6790\u3059\u308b\u3053\u3068\u306b\u3088\u308a (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F1\/\" target=\"figure\" rel=\"noopener\">\u56f31C<\/a>)\u3001\u6211\u3005\u306f\u3001Dox \u66dd\u9732\u5f8c\u306b\u30ec\u30d9\u30eb\u306e\u5897\u52a0\u3092\u793a\u3057\u305f\u4ee3\u8b1d\u7523\u7269\u304c\u4e3b\u306b\u8102\u8cea\u306e\u5206\u985e\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001D-\u30b0\u30eb\u30b3\u30fc\u30b9-6-\u30ea\u30f3\u9178\u3084 AKG \u306a\u3069\u306e\u7cd6\u4ee3\u8b1d\u6307\u6a19\u306e\u30ec\u30d9\u30eb\u306e\u4f4e\u4e0b\u304c\u660e\u3089\u304b\u3067\u3042\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001KEGG \u6fc3\u7e2e\u5206\u6790\u3067\u306f\u3001Dox \u66dd\u9732\u5f8c\u306b\u8102\u8cea\u4ee3\u8b1d\u7d4c\u8def\u304c\u5927\u5e45\u306b\u5909\u5316\u3057\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f (<a class=\"sec\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#s11\">\u88dc\u8db3\u56f3S1<\/a>\uff09\u3002\u5fc3\u7b4b\u5185\u306e FAO \u4ee3\u8b1d\u7269 MDA \u306e\u30ec\u30d9\u30eb (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F1\/\" target=\"figure\" rel=\"noopener\">\u56f31D<\/a>\uff09Dox\u6cbb\u7642\u5f8c\u306b\u6709\u610f\u306b\u4e0a\u6607\u3057\u305f\u3002\u3053\u308c\u306f\u3001Dox \u4ecb\u5165\u5f8c\u306b\u5fc3\u81d3\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u304c\u640d\u306a\u308f\u308c\u3001\u4ee3\u308f\u308a\u306b\u30a8\u30cd\u30eb\u30ae\u30fc\u52b9\u7387\u304c\u6bd4\u8f03\u7684\u4f4e\u3044\u8102\u8cea\u71c3\u713c\u306e\u5897\u52a0\u306b\u3088\u3063\u3066\u7f6e\u304d\u63db\u3048\u3089\u308c\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u4e0d\u9069\u5207\u306a\u8102\u8cea\u4ee3\u8b1d\u306b\u3088\u308a\u3001\u5fc3\u7b4b\u5185\u306b\u5927\u91cf\u306e\u8102\u8cea\u304c\u84c4\u7a4d\u3055\u308c\u3001\u75c5\u7406\u5b66\u7684\u67d3\u8272\u306b\u3088\u308a\u3001Dox \u306b\u66dd\u9732\u3055\u308c\u305f\u52d5\u7269\u306e\u5fc3\u81d3\u306b\u591a\u6570\u306e\u8102\u8cea\u7a7a\u80de\u304c\u5b58\u5728\u3057\u3001\u5fc3\u81d3\u8102\u80aa\u75c7\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F1\/\" target=\"figure\" rel=\"noopener\">\u56f31E<\/a>).<\/p>\n<\/div>\n<div id=\"s3-2\" class=\"sec\">\n<h3 id=\"s3-2title\">\u30a2\u30f3\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u7cfb\u85ac\u5264\u306f\u5fc3\u7b4b\u9178\u7d20\u6d88\u8cbb\u91cf\u3092\u5897\u52a0\u3055\u305b\u3001ATP \u751f\u6210\u901f\u5ea6\u3092\u4f4e\u4e0b\u3055\u305b\u307e\u3059\u3002<\/h3>\n<p class=\"p p-first\">\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u3053\u306e\u4ee3\u8b1d\u88dc\u511f\u306b\u3088\u308a\u5fc3\u7b4b\u306e ROS \u30ec\u30d9\u30eb\u304c\u5897\u52a0\u3057\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u5897\u52a0\u306b\u3064\u306a\u304c\u308a\u307e\u3057\u305f (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\u56f32A<\/a>\uff09\u3002 O2K \u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u5206\u6790\u306b\u3088\u308a\u3001Dox \u304c\u5fc3\u7b4b\u9178\u7d20\u6d88\u8cbb\u91cf\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\u56f32B<\/a>) \u305d\u3057\u3066\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u819c\u306e\u904e\u5206\u6975\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3057\u305f(<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\u56f32C<\/a>) (\u3053\u308c\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u30ec\u30d9\u30eb\u306e\u4e0a\u6607\u306e\u5146\u5019\u3067\u3082\u3042\u308a\u3001\u5fc3\u865a\u8840\u518d\u704c\u6d41\u306e\u30e2\u30c7\u30eb\u3067\u3088\u304f\u898b\u3089\u308c\u307e\u3059)\u3002 JC-1 \u67d3\u8272\u3067\u306f\u3001Dox \u66dd\u9732\u306b\u3088\u308a\u3001\u5c11\u6570\u306e\u751f\u5b58\u7d30\u80de\u306e\u819c\u96fb\u4f4d\u306e\u5897\u52a0 (\u8d64\u8272\u86cd\u5149\u5f37\u5ea6\u306e\u5897\u5f37) \u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u305f\u3053\u3068\u3082\u793a\u3055\u308c\u307e\u3057\u305f (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\u56f32D<\/a>\uff09\u3002\u9178\u7d20\u6d88\u8cbb\u91cf\u306e\u5897\u52a0\u3084\u8102\u8cea\u306e\u9178\u5316\u306a\u3069\u306e\u4ee3\u511f\u30d7\u30ed\u30bb\u30b9\u304c\u5fc3\u81d3\u3067\u767a\u751f\u3057\u307e\u3057\u305f\u304c\u3001\u6b8b\u5ff5\u306a\u3053\u3068\u306b\u3001\u5fc3\u7b4b\u3067\u306e ATP \u751f\u6210\u901f\u5ea6\u306f\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u306e\u4f4e\u4e0b\u306b\u5fdc\u3058\u3066\u5927\u5e45\u306b\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u3002<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\u56f32E<\/a>\uff09\u3002\u9178\u7d20\u6d88\u8cbb\u901f\u5ea6\u3068 ATP \u751f\u6210\u901f\u5ea6\u3092\u6bd4\u8f03\u3059\u308b\u3068\u3001Dox \u66dd\u9732\u306b\u3088\u308a\u5fc3\u7b4b\u306f\u5927\u91cf\u306e\u9178\u7d20\u3092\u6d88\u8cbb\u3059\u308b\u304c\u3001ATP \u306f\u5c11\u91cf\u3057\u304b\u751f\u6210\u3055\u308c\u306a\u3044\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\u56f32F<\/a>\uff09\u3001\u5fc3\u81d3\u3078\u306e\u8ca0\u62c5\u304c\u5927\u5e45\u306b\u5897\u52a0\u3057\u307e\u3059\u3002\u3053\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u51fa\u529b\u306e\u4e0d\u8db3\u306b\u3088\u308a\u3001Dox \u30b0\u30eb\u30fc\u30d7\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u53d7\u5bb9\u4f53 AMPK \u306e\u30ec\u30d9\u30eb\u304c\u5927\u5e45\u306b\u5897\u52a0\u3057\u307e\u3057\u305f (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\u56f32G<\/a>\uff09\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u30a2\u30f3\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u306b\u3088\u308b\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u969c\u5bb3\u306b\u5fdc\u3058\u3066\u3001\u5fc3\u81d3\u306f\u9ad8\u3044\u9178\u7d20\u6d88\u8cbb\u7387\u3068\u4f4e\u3044ATP\u7523\u751f\u7387\u3092\u793a\u3057\u3001\u3053\u306e\u73fe\u8c61\u306f\u5fc3\u7b4b\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u8981\u6c42\u3092\u5b8c\u5168\u306b\u306f\u6e80\u305f\u3055\u305a\u3001\u904e\u5270\u306a\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u5f15\u304d\u8d77\u3053\u3059\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u4eee\u8aac\u3092\u7acb\u3066\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u30ae\u30e3\u30c3\u30d7\u306b\u5fdc\u7b54\u3057\u3066\u3001\u5fc3\u81d3\u5185\u306e\u8102\u8cea\u9178\u5316\u304c\u5897\u52a0\u3057\u3001\u3088\u308a\u591a\u304f\u306eROS\u304c\u84c4\u7a4d\u3057\u3001\u3053\u306e\u8ca7\u5f31\u306a\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u7d4c\u8def\u304cDIC\u306e\u91cd\u8981\u306a\u8981\u56e0\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u63a8\u6e2c\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<div id=\"F2\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm139983201580624\">\n<div class=\"ts_bar small\" title=\"\u753b\u50cf\u3092\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u3057\u307e\u3059\"><\/div>\n<p><a class=\"inline_block ts_canvas\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/core\/lw\/2.0\/html\/tileshop_pmc\/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&amp;p=PMC3&amp;id=9551275_fphar-13-930835-g002.jpg\" target=\"tileshopwindow\" rel=\"noopener\"><img decoding=\"async\" class=\"tileshop\" title=\"\u753b\u50cf\u3092\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u3057\u307e\u3059\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/bin\/fphar-13-930835-g002.jpg\" alt=\"An external file that holds a picture, illustration, etc.Object name is fphar-13-930835-g002.jpg\" \/><\/a><\/div>\n<div id=\"lgnd_F2\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\u56f32<\/a><\/div>\n<div class=\"caption\">\n<p><strong>(A)<\/strong>\u00a0H9c2 \u7d30\u80de\u306b\u304a\u3051\u308b ROS \u67d3\u8272\u306e\u5f37\u5ea6\u3002\u00a0<strong>(B)<\/strong>\u00a0H9c2 \u7d30\u80de\u306e\u5fc3\u81d3\u9178\u7d20\u6d88\u8cbb\u91cf\u3002\u00a0<strong>(C)<\/strong>\u00a0\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u819c\u96fb\u4f4d\u3002\u00a0<strong>(D)<\/strong>\u00a0JC-1\u67d3\u8272\u3068\u68d2\u30b0\u30e9\u30d5\u3002\u00a0<strong>(\u30db)<\/strong>\u00a0H9c2 \u7d30\u80de\u306e ATP \u542b\u6709\u91cf\u3002\u00a0<strong>(F)<\/strong>\u00a0H9c2\u7d30\u80de\u306b\u304a\u3051\u308bATP\u7523\u751f\/\u9178\u7d20\u6d88\u8cbb\u6bd4\u3002\u00a0<strong>(G)<\/strong>\u00a0AMPK\u304a\u3088\u3073\u03b2-\u30c1\u30e5\u30fc\u30d6\u30ea\u30f3\u306e\u767a\u73fe\u30ec\u30d9\u30eb\u3092\u6e2c\u5b9a\u3057\u305f\u00a0<em>\u8a66\u9a13\u7ba1\u5185\u3067<\/em>\u00a0WB\u8457\u3002\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u5bfe Dox: ***<em>p<\/em>\u00a0&lt; 0.0005\u3001**<em>p<\/em>\u00a0&lt; 0.005\u3001*<em>p<\/em>\u00a0&lt; 0.05\u3001\u5e73\u5747\u00b1SD\u3002\u00a0<em>n<\/em>\u00a0= 6\u20139\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"s3-3\" class=\"sec\">\n<h3 id=\"s3-3title\">\u65b0\u3057\u3044\u5fc3\u81d3\u4fdd\u8b77\u5264\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u5fc3\u81d3\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u3092\u4fc3\u9032\u3057\u3001Dox \u8a98\u767a\u6027\u5fc3\u7b4b\u75c7\u3092\u6291\u5236\u3057\u307e\u3059<\/h3>\n<p class=\"p p-first\">\u524d\u8ff0\u306e\u7d50\u679c\u306b\u89e6\u767a\u3055\u308c\u3066\u3001\u6211\u3005\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u6cbb\u7642\u306b\u4f7f\u7528\u3055\u308c\u308b\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9 \u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e DIC \u306e\u9032\u884c\u306b\u5bfe\u3059\u308b\u4fdd\u8b77\u52b9\u679c\u3092\u4ee3\u8b1d\u306e\u89b3\u70b9\u304b\u3089\u8abf\u67fb\u3057\u307e\u3057\u305f\u3002\u5b9f\u9a13\u30d7\u30ed\u30c8\u30b3\u30eb\u3092\u4ee5\u4e0b\u306b\u793a\u3057\u307e\u3059\u3002\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F3\/\" target=\"figure\" rel=\"noopener\">\u56f33A<\/a>\u3001 \u305d\u3057\u3066\u00a0<sup>18<\/sup>\u6700\u521d\u306e\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u6ce8\u5c04\u304b\u3089 1 \u9031\u9593\u5f8c\u306e\u30de\u30a6\u30b9\u3092\u4f7f\u7528\u3057\u3066\u3001F-FDG PET\/CT \u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3092\u5b9f\u884c\u3057\u307e\u3057\u305f\u3002\u306b\u793a\u3059\u3088\u3046\u306b\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F3\/\" target=\"figure\" rel=\"noopener\">\u56f33B<\/a>\u3001\u5fc3\u81d3\u53d6\u308a\u8fbc\u307f\u306f\u3001Dox \u6cbb\u7642\u5358\u72ec\u7fa4\u3088\u308a\u3082\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u6cbb\u7642\u7fa4\u306e\u65b9\u304c\u6709\u610f\u306b\u9ad8\u304f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u4ecb\u5165\u304c Dox \u306b\u3088\u308b\u5fc3\u81d3\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u306e\u6e1b\u5c11\u3092\u9006\u8ee2\u3055\u305b\u3001\u5fc3\u81d3\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3092\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u6b21\u306b\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306b\u3088\u308b\u6cbb\u7642\u5f8c\u306e\u5fc3\u81d3\u6a5f\u80fd\u3068\u75c5\u7406\u5b66\u7684\u5909\u5316\u304c\u691c\u67fb\u3055\u308c\u3001\u81e8\u5e8a\u85ac\u30c7\u30af\u30b9\u30e9\u30be\u30ad\u30b5\u30f3 (Dexra) \u304c\u967d\u6027\u5bfe\u7167\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u3002\u5fc3\u30a8\u30b3\u30fc\u691c\u67fb\u3067\u306f\u3001\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F3\/\" target=\"figure\" rel=\"noopener\">\u56f33C<\/a>\u00a0Dox \u30b0\u30eb\u30fc\u30d7\u306e LVEF \u3068 LVFS \u306f\u5bfe\u7167\u30b0\u30eb\u30fc\u30d7\u3088\u308a\u3082\u6709\u610f\u306b\u4f4e\u304f\u3001LVESV \u3068 LVD \u306f\u5bfe\u7167\u30b0\u30eb\u30fc\u30d7\u3088\u308a\u6709\u610f\u306b\u9ad8\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001Dox \u6cbb\u7642\u5f8c\u306b\u30de\u30a6\u30b9\u306e\u5de6\u5fc3\u5ba4\u53ce\u7e2e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u3053\u306e\u7814\u7a76\u306b\u304a\u3051\u308b Dox \u8a98\u767a\u5fc3\u7b4b\u640d\u50b7\u306f\u62e1\u5f35\u578b\u5fc3\u7b4b\u75c7\u306b\u985e\u4f3c\u3057\u3066\u3044\u305f\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002 Dox \u306f\u53ce\u7e2e\u6a5f\u80fd\u3092\u4f4e\u4e0b\u3055\u305b\u307e\u3059\u3002\u3053\u308c\u306f\u4ee5\u524d\u306b\u5831\u544a\u3055\u308c\u305f\u3082\u306e\u3068\u540c\u69d8\u3067\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B46\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30d9\u30f3\u30c1\u30e5\u30ea\u30fc\u30cb\u3089\u30011996<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B41\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30b5\u30f3\u4ed6\u30012022<\/a>\uff09\u3002\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u306e\u307f\u3067\u6cbb\u7642\u3057\u305f\u52d5\u7269\u306e\u5fc3\u81d3\u3068\u6bd4\u8f03\u3057\u3066\u3001Brev \u3068 Dox \u3067\u6cbb\u7642\u3057\u305f\u52d5\u7269\u306e\u5fc3\u81d3\u3067\u306f\u3059\u3079\u3066\u306e\u6a5f\u80fd\u304c\u56de\u5fa9\u3057\u307e\u3057\u305f\u3002 cTnI \u306f\u5fc3\u7b4b\u640d\u50b7\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3067\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B40\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30bd\u30e9\u30fc\u30ed\u3068\u30bd\u30e9\u30fc\u30ed\u30012020<\/a>\uff09\u3002 cTnI\u306e\u6fc3\u5ea6\u306f\u3001\u5bfe\u7167\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u5358\u72ec\u3067\u6cbb\u7642\u3057\u305f\u30de\u30a6\u30b9\u3067\u6709\u610f\u306b\u5897\u52a0\u3057\u3001\u7570\u306a\u308b\u6fc3\u5ea6\u306eBrev\u306f\u3088\u308a\u826f\u3044\u52b9\u679c\u3092\u793a\u3057\u305f(<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F3\/\" target=\"figure\" rel=\"noopener\">\u56f33D<\/a>\uff09\u3002\u3055\u3089\u306b\u3001\u3055\u307e\u3056\u307e\u306a\u6cbb\u7642\u5f8c\u306e\u75c5\u7406\u5b66\u7684\u5fc3\u81d3\u7d44\u7e54\u306e\u67d3\u8272\u306b\u3088\u308a\u3001\u5bfe\u7167\u7fa4\u306e\u30de\u30a6\u30b9\u306e\u5fc3\u81d3\u7d44\u7e54\u69cb\u9020\u304c\u6b63\u5e38\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u5bfe\u7167\u7fa4\u306e\u30de\u30a6\u30b9\u3068\u306f\u7570\u306a\u308a\u3001Dox \u7fa4\u306e\u30de\u30a6\u30b9\u306f\u3001\u58ca\u6b7b\u3001\u7d30\u80de\u5185\u6d6e\u816b\u3001\u7b4b\u539f\u7dda\u7dad\u306e\u969c\u5bb3\u3068\u7834\u88c2\u3001\u5fc3\u81d3\u7dda\u7dad\u306e\u6ce2\u72b6\u5909\u6027\u306a\u3069\u306e\u591a\u6570\u306e\u5fc3\u81d3\u75c5\u5909\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306b\u3088\u308b\u30d7\u30ec\u30b3\u30f3\u30c7\u30a3\u30b7\u30e7\u30cb\u30f3\u30b0\u306f\u3053\u306e\u7a2e\u306e\u50b7\u5bb3\u3092\u4e88\u9632\u3057\u3001\u5fc3\u81d3\u8102\u8cea\u306e\u904e\u5270\u306a\u84c4\u7a4d\u3092\u8efd\u6e1b\u3057\u3001\u5fc3\u7b4b\u306e\u6052\u5e38\u6027\u3092\u56de\u5fa9\u3057\u307e\u3057\u305f\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F3\/\" target=\"figure\" rel=\"noopener\">\u56f33F<\/a>\uff09\u3002\u5fc3\u7b4b\u306e\u30de\u30c3\u30bd\u30f3\u67d3\u8272\u3067\u306f\u3001Dox \u6cbb\u7642\u5f8c\u306b\u9593\u8cea\u6027\u7dda\u7dad\u75c7\u304c\u6709\u610f\u306b\u5897\u52a0\u3057\u3001Brev \u4ecb\u5165\u306b\u3088\u308a\u5fc3\u7dda\u7dad\u75c7\u306e\u7a0b\u5ea6\u304c\u6e1b\u5c11\u3057\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F3\/\" target=\"figure\" rel=\"noopener\">\u56f33E<\/a>\uff09\u3002\u5fc3\u81d3\u8d85\u97f3\u6ce2\u30c7\u30fc\u30bf\u306f\u3001LVESV \u3068 LVID \u304c\u5bfe\u7167\u7fa4\u3088\u308a\u3082 Dox \u7fa4\u3067\u6709\u610f\u306b\u9ad8\u3044\u3053\u3068\u3092\u793a\u3057\u3001\u3053\u308c\u306f\u5fc3\u5ba4\u8154\u76f4\u5f84\u306e\u62e1\u5927\u3092\u793a\u5506\u3057\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u6cbb\u7642\u304c\u3053\u308c\u3089\u306e\u5909\u5316\u3092\u5927\u5e45\u306b\u8efd\u6e1b\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u5fc3\u81d3\u306e\u4ee3\u8b1d\u3092\u518d\u69cb\u7bc9\u3057\u3001\u5fc3\u81d3\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u3092\u5897\u52a0\u3055\u305b\u3001\u5fc3\u81d3\u306e\u8102\u80aa\u75c7\u3092\u8efd\u6e1b\u3057\u3001\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u8a98\u767a\u6027\u306e\u5fc3\u81d3\u6a5f\u80fd\u4e0d\u5168\u3068\u5fc3\u7b4b\u5f62\u614b\u306e\u5909\u5316\u3092\u8efd\u6e1b\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<div id=\"F3\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm139983204545024\">\n<div class=\"ts_bar small\" title=\"\u753b\u50cf\u3092\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u3057\u307e\u3059\"><\/div>\n<p><a class=\"inline_block ts_canvas\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/core\/lw\/2.0\/html\/tileshop_pmc\/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&amp;p=PMC3&amp;id=9551275_fphar-13-930835-g003.jpg\" target=\"tileshopwindow\" rel=\"noopener\"><img decoding=\"async\" class=\"tileshop\" title=\"\u753b\u50cf\u3092\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u3057\u307e\u3059\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/bin\/fphar-13-930835-g003.jpg\" alt=\"An external file that holds a picture, illustration, etc.Object name is fphar-13-930835-g003.jpg\" \/><\/a><\/div>\n<div id=\"lgnd_F3\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F3\/\" target=\"figure\" rel=\"noopener\">\u56f33<\/a><\/div>\n<div class=\"caption\">\n<p><strong>(A)<\/strong>\u00a0\u30de\u30a6\u30b9\u6cbb\u7642\u306e\u6982\u7565\u30d7\u30ed\u30c8\u30b3\u30eb\u3002\u00a0<strong>(B)<\/strong>\u00a0<sup>18<\/sup>\u6700\u521d\u306e Dox \u66dd\u9732\u306e 1 \u9031\u9593\u5f8c\u306b\u30de\u30a6\u30b9\u3092\u4f7f\u7528\u3057\u3066 F-FDG PET\/CT \u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3092\u5b9f\u884c\u3057\u300118 F-FDG \u306e\u6fc3\u5ea6\u304c\u5fc3\u81d3\u306b\u53d6\u308a\u8fbc\u307e\u308c\u307e\u3057\u305f\u3002\u00a0<strong>(C)<\/strong>\u00a0\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c Dox \u306b\u3088\u3063\u3066\u8a98\u767a\u3055\u308c\u305f\u5de6\u5fc3\u5ba4\u62e1\u5f35\u3092\u9632\u6b62\u3057\u305f\u3053\u3068\u3092\u793a\u3059\u5fc3\u30a8\u30b3\u30fc\u56f3\u3002\u4ee3\u8868\u7684\u306a M \u30e2\u30fc\u30c9\u77ed\u8ef8\u5fc3\u30a8\u30b3\u30fc\u56f3\u306f\u3001Dox \u304c\u5de6\u5fc3\u5ba4\u62e1\u5f35\u3092\u8a98\u767a\u3057\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c Dox + Brev \u30b0\u30eb\u30fc\u30d7\u3067\u4fdd\u8b77\u52b9\u679c\u3092\u767a\u63ee\u3057\u305f\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u62e1\u5f35\u671f\u306eEF\u304a\u3088\u3073FS\u306f\u3001Dox\u3067\u6cbb\u7642\u3057\u305f\u30de\u30a6\u30b9\u3088\u308a\u3082\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u3067\u6cbb\u7642\u3057\u305f\u30de\u30a6\u30b9\u306e\u65b9\u304c\u6709\u610f\u306b\u4f4e\u304f\u3001HR\u306f\u6709\u610f\u306b\u9ad8\u304b\u3063\u305f\u3002\u00a0<strong>(D)<\/strong>\u00a0\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f cTnI \u306e\u6fc3\u5ea6\u3092\u4f4e\u4e0b\u3055\u305b\u307e\u3057\u305f\u3002\u00a0<strong>(\u30db)<\/strong>\u00a0\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c Dox \u306b\u3088\u3063\u3066\u8a98\u767a\u3055\u308c\u308b\u5fc3\u81d3\u7dda\u7dad\u75c7\u306e\u7a0b\u5ea6\u3092\u8efd\u6e1b\u3059\u308b\u3053\u3068\u3092\u793a\u3059\u30de\u30c3\u30bd\u30f3\u67d3\u8272\u3002\u00a0<strong>(F)<\/strong>\u00a0HE \u67d3\u8272\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u5fc3\u81d3\u5185\u306e Dox \u306b\u3088\u3063\u3066\u8a98\u767a\u3055\u308c\u308b\u5fc3\u7b4b\u7d30\u80de\u30b5\u30a4\u30ba\u306e\u6e1b\u5c11\u304b\u3089\u4fdd\u8b77\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u5bfe Dox\u30014 mg\/kg\u30018 mg\/kg\u3001\u307e\u305f\u306f 16 mg\/kg Brev \u5bfe Dox \u304a\u3088\u3073 Dexra \u5bfe Dox: ***<em>p<\/em>\u00a0&lt; 0.0005\u3001**<em>p<\/em>\u00a0&lt; 0.005\u3001*<em>p<\/em>\u00a0&lt; 0.05\u3001\u5e73\u5747\u00b1SD\u3002\u00a0<em>n<\/em>\u00a0= 6\u20139\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"s3-4\" class=\"sec\">\n<h3 id=\"s3-4title\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001\u672b\u68a2\u8840\u6e05\u30ec\u30d9\u30eb\u3068\u5fc3\u7b4bAKT\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u5fc3\u81d3\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u3068\u8102\u8cea\u306e\u4ee3\u8b1d\u3092\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3057\u307e\u3059\u3002<\/h3>\n<p class=\"p p-first\">\u6b21\u306b\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u7cd6\u3068\u8102\u80aa\u306e\u4ee3\u8b1d\u30d0\u30e9\u30f3\u30b9\u3092\u3069\u306e\u3088\u3046\u306b\u8abf\u7bc0\u3059\u308b\u304b\u3092\u7814\u7a76\u3057\u307e\u3057\u305f\u3002\u306b\u793a\u3059\u3088\u3046\u306b\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F4\/\" target=\"figure\" rel=\"noopener\">\u56f34E<\/a>\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u3067\u6cbb\u7642\u3057\u305f\u30de\u30a6\u30b9\u306e\u672b\u68a2\u8840\u6e05\u4e2d\u306e\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u30ec\u30d9\u30eb\u306f\u3001Dox \u3067\u6cbb\u7642\u3057\u305f\u30de\u30a6\u30b9\u3068\u6bd4\u8f03\u3057\u3066\u5287\u7684\u306b\u5897\u52a0\u3057\u3001\u6e1b\u5c11\u306e\u7a0b\u5ea6\u306f\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u7528\u91cf\u3068\u76f4\u7dda\u95a2\u4fc2\u3092\u793a\u3057\u300195% \u4ee5\u4e0a\u306e\u6e1b\u5c11\u306f\u9ad8\u7528\u91cf\u7fa4\u3067\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u30bb\u30ed\u30c8\u30cb\u30f3 (5-HT) \u306f\u3001\u795e\u7d4c\u7cfb\u304a\u3088\u3073\u975e\u795e\u7d4c\u7cfb\u3067\u3055\u307e\u3056\u307e\u306a\u6a5f\u80fd\u3092\u6301\u3064\u30e2\u30ce\u30a2\u30df\u30f3\u3067\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B31\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30aa\u30ab\u30c6\u30a3\u3089\u30012019<\/a>\uff09\u3002\u4e2d\u67a2\u795e\u7d4c\u7cfb\u3067\u306f\u30015-HT \u306f\u6c17\u5206\u3084\u6442\u98df\u884c\u52d5\u3092\u8abf\u7bc0\u3059\u308b\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B2\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30d0\u30fc\u30ac\u30fc\u4ed6\u30012009<\/a>\uff09\u3002\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u672b\u68a2\u306e 5-HT \u304c\u8910\u8272\u8102\u80aa\u7d44\u7e54\u306b\u304a\u3051\u308b\u9069\u5fdc\u71b1\u7523\u751f\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u672b\u68a2\u7d44\u7e54\u306e\u4ee3\u8b1d\u8abf\u7bc0\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 5-HT \u5408\u6210\u306e\u963b\u5bb3\u306b\u3088\u308a\u3001\u98df\u4e8b\u8a98\u767a\u6027\u80a5\u6e80\u30de\u30a6\u30b9 \u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u4f53\u91cd\u5897\u52a0\u304c\u6e1b\u5c11\u3057\u3001\u4ee3\u8b1d\u6a5f\u80fd\u969c\u5bb3\u304c\u6539\u5584\u3055\u308c\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B56\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30bc\u30e0\u30c7\u30b0\u30b9\u3089\u30012016<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B51\" aria-expanded=\"false\" aria-haspopup=\"true\">\u590f\u4ed6\u30012021<\/a>\uff09\u3002\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u7814\u7a76\u306b\u3088\u308a\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u4f5c\u52d5\u7cfb\u3068\u80a5\u6e80\u3068\u306e\u907a\u4f1d\u7684\u95a2\u9023\u6027\u3082\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u30bb\u30ed\u30c8\u30cb\u30f3\u306f\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u306b\u5bfe\u3057\u3066 2 \u3064\u306e\u7570\u306a\u308b\u52b9\u679c\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u30021 \u3064\u306f\u81b5\u81d3 B \u7d30\u80de\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u76f4\u63a5\u8a98\u5c0e\u3057\u3001\u8840\u7cd6\u5024\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u3067\u3059\u3002\u809d\u81d3\u3084\u9aa8\u683c\u7b4b\u4ee5\u5916\u306e\u7d44\u7e54\u306b\u3088\u308b\u8840\u6db2\u304b\u3089\u306e\u30d6\u30c9\u30a6\u7cd6\u306e\u53d6\u308a\u8fbc\u307f\u3092\u963b\u5bb3\u3057\u3001\u8840\u7cd6\u5024\u3092\u4e0a\u6607\u3055\u305b\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B47\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6e21\u8fba\u307b\u304b\u30012011<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B4\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ab\u30eb\u30df\u30a2\u30f3\u3089\u30012019<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B53\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30e4\u30d6\u30c8\u3089\u30012019<\/a>\uff09\u3002\u7814\u7a76\u3067\u306f\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u6cbb\u7642\u304c\u8840\u7cd6\u5024\u306e\u7a81\u7136\u306e\u5927\u5e45\u306a\u4e0a\u6607\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u304c\u8840\u6db2\u304b\u3089\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u306e\u7d44\u7e54\u53d6\u308a\u8fbc\u307f\u3092\u3069\u306e\u3088\u3046\u306b\u963b\u5bb3\u3059\u308b\u304b\u306f\u307e\u3060\u4e0d\u660e\u3067\u3059\u3002\u79c1\u305f\u3061\u306e\u5b9f\u9a13\u7d50\u679c\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u6cbb\u7642\u5f8c\u3001\u5fc3\u81d3\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u6442\u53d6\u91cf\u306e\u5897\u52a0\u306b\u5bfe\u5fdc\u3057\u3066\u3001\u672b\u68a2\u30bb\u30ed\u30c8\u30cb\u30f3\u30ec\u30d9\u30eb\u304c\u6025\u6fc0\u306b\u6e1b\u5c11\u3057\u305f\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F4\/\" target=\"figure\" rel=\"noopener\">\u56f34E<\/a>\uff09\u3001\u809d\u81d3\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u6442\u53d6\u91cf\u306f\u5927\u304d\u304f\u5909\u5316\u3057\u307e\u305b\u3093\u3067\u3057\u305f\uff08<a class=\"sec\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#s11\">\u88dc\u8db3\u56f3S2<\/a>\uff09\u3001\u7a7a\u8179\u6642\u8840\u7cd6\u5024\uff08FBG\uff09\u30ec\u30d9\u30eb\u304c\u4f4e\u4e0b\u3057\u307e\u3057\u305f\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F4\/\" target=\"figure\" rel=\"noopener\">\u56f34A<\/a>\uff09\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u7fa4\u3067\u306f\u30015-HT \u3092\u8ffd\u52a0\u6295\u4e0e\u3059\u308b\u3068\u3001\u30de\u30a6\u30b9\u306e\u30bb\u30ed\u30c8\u30cb\u30f3\u30ec\u30d9\u30eb\u304c\u5897\u52a0\u3057\u3001\u5fc3\u81d3\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u304c\u6e1b\u5c11\u3057\u307e\u3057\u305f (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F4\/\" target=\"figure\" rel=\"noopener\">\u56f34B<\/a>\uff09\u3002\u30bb\u30ed\u30c8\u30cb\u30f3\u304c\u5fc3\u7b4b\u7d30\u80de\u306e\u4ee3\u8b1d\u3092\u3069\u306e\u3088\u3046\u306b\u8abf\u7bc0\u3059\u308b\u304b\u3092\u3055\u3089\u306b\u89e3\u6790\u3059\u308b\u305f\u3081\u306b\u3001Dox \u8a98\u767a\u5fc3\u7b4b\u640d\u50b7\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306b 5-HT \u3092\u8ffd\u52a0\u3057\u3066\u30bb\u30ed\u30c8\u30cb\u30f3\u30ec\u30d9\u30eb\u3092\u4e0a\u6607\u3055\u305b\u3001\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u306e\u305f\u3081\u306b\u30de\u30a6\u30b9\u306e\u5fc3\u81d3\u3092\u53ce\u96c6\u3057\u307e\u3057\u305f\u3002\u7d50\u679c\u306f\u3001Dox \u3068 5-HT \u3067\u6cbb\u7642\u3057\u305f\u30b0\u30eb\u30fc\u30d7\u306e\u8102\u80aa\u9178\u306e\u9178\u5316\u304c\u3001Dox \u5358\u72ec\u30b0\u30eb\u30fc\u30d7\u3088\u308a\u3082\u6709\u610f\u306b\u9ad8\u3044\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f (<a class=\"sec\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#s11\">\u88dc\u8db3\u56f3S3<\/a>\uff09\u3002\u6b21\u306b\u3001\u6211\u3005\u306f\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u306e\u8abf\u7bc0\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u5fc3\u7b4b\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u306e\u91cd\u8981\u306a\u8abf\u7bc0\u56e0\u5b50\u3067\u3042\u308bPI3K\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bcB\uff08Akt\/PKB\uff09\u7d4c\u8def\u306e\u5909\u5316\u3092\u5206\u6790\u3057\u305f\u3002\u7d30\u80de\u306e\u5206\u88c2\u3001\u5897\u6b96\u3001\u751f\u5b58\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u305d\u3057\u3066\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u963b\u5bb3\u3057\u307e\u3059\u3002\u7d50\u679c\u306f\u30015-HT \u306e\u6dfb\u52a0\u304c Akt \u306e\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u76f4\u63a5\u963b\u5bb3\u3059\u308b\u304c\u3001PI3K \u89e6\u5a92\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u307e\u305f\u306f\u8abf\u7bc0\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306e\u30ec\u30d9\u30eb\u306b\u306f\u6709\u610f\u306a\u5909\u5316\u306f\u751f\u3058\u306a\u3044\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F4\/\" target=\"figure\" rel=\"noopener\">\u56f34C<\/a>\uff09\u3002 AKT \u304c\u5931\u308f\u308c\u308b\u3068\u3001\u5fc3\u7b4b\u7d30\u80de\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u80fd\u529b\u304c\u4f4e\u4e0b\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u30ec\u30d9\u30eb\u3092\u5927\u5e45\u306b\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u3067\u7d44\u7e54\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u306b\u5bfe\u3059\u308b\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u963b\u5bb3\u52b9\u679c\u3092\u7de9\u548c\u3057\u3001\u75c5\u7684\u72b6\u614b\u4e0b\u3067\u8840\u6db2\u304b\u3089\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u306e\u5438\u53ce\u3092\u78ba\u5b9f\u306b\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u304a\u308a\u3001\u8eab\u4f53\u304c\u5fc3\u81d3\u4ee3\u8b1d\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u307e\u3059\u3002\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u3092\u4ecb\u3057\u305f\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3002\u3055\u3089\u306b\u91cd\u8981\u306a\u3053\u3068\u306f\u3001\u4e2d\u56fd\u3067\u4e00\u822c\u7684\u306b\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u5fc3\u81d3\u8840\u7ba1\u85ac\u3067\u3042\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001\u672b\u68a2\u30bb\u30ed\u30c8\u30cb\u30f3\u30ec\u30d9\u30eb\u309290%\u4ee5\u4e0a\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u5fc3\u7b4b\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u306b\u3088\u3063\u3066\u8a98\u767a\u3055\u308c\u308b\u5fc3\u7b4b\u80a5\u5927\u304a\u3088\u3073\u5fc3\u4e0d\u5168\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u3001\u53e4\u5178\u7684\u306a\u30bb\u30ed\u30c8\u30cb\u30f3\u518d\u53d6\u308a\u8fbc\u307f\u963b\u5bb3\u5264\u3067\u3042\u308b\u30d5\u30eb\u30aa\u30ad\u30bb\u30c1\u30f3\u3088\u308a\u3082\u5f37\u529b\u306a\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u3053\u3068\u3067\u3059\u3002\u969c\u5bb3\u304a\u3088\u3073\u7cd6\u5c3f\u75c5\u3092\u6cbb\u7642\u3059\u308b\u305f\u3081\u306e\u3001Dox \u8a98\u767a\u6027\u5fc3\u6bd2\u6027\u306e\u65b0\u3057\u3044\u5b89\u5168\u306a\u6cbb\u7642\u85ac\u3067\u3059\u3002\u75ab\u5b66\u7814\u7a76\u3067\u306f\u3001\u7cd6\u5c3f\u75c5\u304c Dox \u8a98\u767a\u6027\u5fc3\u6bd2\u6027\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u3082\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u3053\u306e\u7814\u7a76\u306f\u3001\u7cd6\u5c3f\u75c5\u3068\u764c\u306e\u60a3\u8005\u306b\u5bfe\u3059\u308b\u6f5c\u5728\u7684\u306a\u6cbb\u7642\u6226\u7565\u3092\u63d0\u4f9b\u3057\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B5\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30c1\u30e3\u30f3\u4ed6\u30012021<\/a>).<\/p>\n<div id=\"F4\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm139983196531152\">\n<div class=\"ts_bar small\" title=\"\u753b\u50cf\u3092\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u3057\u307e\u3059\"><\/div>\n<p><a class=\"inline_block ts_canvas\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/core\/lw\/2.0\/html\/tileshop_pmc\/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&amp;p=PMC3&amp;id=9551275_fphar-13-930835-g004.jpg\" target=\"tileshopwindow\" rel=\"noopener\"><img decoding=\"async\" class=\"tileshop\" title=\"\u753b\u50cf\u3092\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u3057\u307e\u3059\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/bin\/fphar-13-930835-g004.jpg\" alt=\"An external file that holds a picture, illustration, etc.Object name is fphar-13-930835-g004.jpg\" \/><\/a><\/div>\n<div id=\"lgnd_F4\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F4\/\" target=\"figure\" rel=\"noopener\">\u56f34<\/a><\/div>\n<div class=\"caption\">\n<p><strong>(A)<\/strong>\u00a0\u30de\u30a6\u30b9\u306e\u7a7a\u8179\u6642\u8840\u7cd6\u5024\u3002\u00a0<strong>(B)<\/strong>\u00a0\u306e\u6fc3\u5ea6\u00a0<sup>18<\/sup>5-HT \u3092\u88dc\u7d66\u3059\u308b\u3068\u3001F-FDG \u304c\u5fc3\u81d3\u306b\u53d6\u308a\u8fbc\u307e\u308c\u307e\u3059\u3002\u00a0<strong>(C)<\/strong>\u00a05-HT\u6dfb\u52a0\u5f8c\u306e\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u306e\u30d2\u30fc\u30c8\u30de\u30c3\u30d7\u3002\u00a0<strong>(D)<\/strong>\u00a0PI3K\u3001Akt\u3001GAPDH\u306e\u767a\u73fe\u91cf\u3092\u6e2c\u5b9a\u3057\u305f\u00a0<em>\u8a66\u9a13\u7ba1\u5185\u3067<\/em>\u00a0WB\u8457\u3002\u00a0<strong>(\u30db)<\/strong>\u00a0\u30de\u30a6\u30b9\u306e\u672b\u68a2\u8840\u6e05\u4e2d\u306e\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u30ec\u30d9\u30eb\u3002\u00a0<strong>(F)<\/strong>\u00a0\u30de\u30a6\u30b9\u306e D-\u30b0\u30eb\u30b3\u30fc\u30b9 6-\u30ea\u30f3\u9178\u306e\u30ec\u30d9\u30eb\u3002\u00a0<strong>(G)<\/strong>\u00a0\u30de\u30a6\u30b9\u306e\u03b1-\u30b1\u30c8\u30b0\u30eb\u30bf\u30eb\u9178\u306e\u30ec\u30d9\u30eb\u3002\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u5bfe Dox\u30014 mg\/kg\u30018 mg\/kg\u3001\u307e\u305f\u306f 16 mg\/kg Brev \u5bfe Dox \u304a\u3088\u3073 Brev+5-HT \u5bfe Brev: ***<em>p<\/em>\u00a0&lt; 0.0005\u3001**<em>p<\/em>\u00a0&lt; 0.005\u3001*<em>p<\/em>\u00a0&lt; 0.05\u3001\u5e73\u5747\u00b1SD\u3002\u00a0<em>n<\/em>\u00a0= 6\u20139\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p class=\"p\">\u3053\u308c\u3089\u306e\u767a\u898b\u306b\u57fa\u3065\u3044\u3066\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u3069\u306e\u3088\u3046\u306b\u30b0\u30eb\u30b3\u30fc\u30b9\u3092\u8abf\u7bc0\u3059\u308b\u304b\u3092\u8abf\u67fb\u3057\u307e\u3057\u305f\u3002\u5fc3\u304b\u3089\u306e\u6d3b\u7528\u3002\u305d\u306e\u7d50\u679c\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u4ecb\u5165\u5f8c\u3001Dox \u66dd\u9732\u30de\u30a6\u30b9\u306b\u304a\u3051\u308b PI3K \u30bf\u30f3\u30d1\u30af\u8cea\u767a\u73fe\u304c\u6709\u610f\u306b\u6e1b\u5c11\u3057\u3001\u5fc3\u81d3\u7d44\u7e54\u306b\u304a\u3051\u308b PI3K \u30bf\u30f3\u30d1\u30af\u8cea\u767a\u73fe\u30ec\u30d9\u30eb\u304c\u6709\u610f\u306b\u5897\u52a0\u3057\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001AKT \u767a\u73fe\u306f\u5bfe\u7167\u7fa4\u3068 Dox \u66dd\u9732\u7fa4\u306e\u4e21\u65b9\u3067\u4f4e\u30ec\u30d9\u30eb\u306b\u7dad\u6301\u3055\u308c\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u6cbb\u7642\u5f8c\u306b AKT \u767a\u73fe\u306e\u6709\u610f\u306a\u5897\u52a0\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F4\/\" target=\"figure\" rel=\"noopener\">\u56f34D<\/a>\uff09\u3002\u4ee5\u524d\u306e\u7814\u7a76\u3067\u306f\u3001AKT\u304c\u7d30\u80de\u5185\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u3092\u523a\u6fc0\u3057\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u3092D-\u30b0\u30eb\u30b3\u30fc\u30b96-\u30ea\u30f3\u9178\u306b\u5909\u63db\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u00a0<em>\u7d4c\u7531<\/em>\u00a0\u89e3\u7cd6\u307e\u305f\u306f\u30b0\u30ea\u30b3\u30fc\u30b2\u30f3\u3078\u306e\u91cd\u5408\u306e\u305f\u3081\u306e\u30d8\u30ad\u30bd\u30ad\u30ca\u30fc\u30bc\u3002\u79c1\u305f\u3061\u306e\u7d50\u679c\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u5fc3\u7b4bAKT\u306e\u767a\u73fe\u3092\u4fc3\u9032\u3057\u305f\u5f8c\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u306b\u95a2\u9023\u3059\u308bD-\u30b0\u30eb\u30b3\u30fc\u30b96-\u30ea\u30f3\u9178\u304a\u3088\u3073\u03b1-\u30b1\u30c8\u30b0\u30eb\u30bf\u30eb\u9178\u30ec\u30d9\u30eb\u304c\u6709\u610f\u306b\u5897\u52a0\u3057\u305f\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F4\/\" target=\"figure\" rel=\"noopener\">\u56f34F<\/a>\u3001G\uff09\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304cAKT\u3092\u4ecb\u3057\u3066\u30b0\u30eb\u30b3\u30fc\u30b9\u3092\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\u3068\u3057\u3066\u4f7f\u7528\u3059\u308b\u5fc3\u7b4b\u306e\u80fd\u529b\u3092\u9ad8\u3081\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u7570\u5316\u3092\u4fc3\u9032\u3057\u305f\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u306f\u3001PI3K-Akt\u767a\u73fe\u306e\u5897\u52a0\u304c\u672b\u68a2\u7d44\u7e54\u3067\u306e\u7cd6\u5229\u7528\u3092\u4fc3\u9032\u3057\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u5fc3\u81d3\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4f9b\u7d66\u3092\u5f37\u5316\u3057\u3001\u5fc3\u4e0d\u5168\u3092\u4e88\u9632\u3067\u304d\u308b\u4e00\u65b9\u3001PI3K-Akt\u7d4c\u8def\u306e\u963b\u5bb3\u306f\u5fc3\u81d3\u7d30\u80de\u306e\u751f\u7406\u6d3b\u6027\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B57\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6731\u4ed6\u30012013<\/a>\uff09\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304cPI3K-Akt\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001Dox\u8a98\u767a\u6027\u5fc3\u7b4b\u640d\u50b7\u306b\u5bfe\u3059\u308b\u8010\u6027\u3092\u5f37\u5316\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u30bb\u30ed\u30c8\u30cb\u30f3\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u8840\u7cd6\u5024\u3092\u8abf\u7bc0\u3057\u3001\u5fc3\u7b4b\u306b\u304a\u3051\u308b\u30b0\u30eb\u30b3\u30fc\u30b9\u5229\u7528\u306e\u5236\u9650\u3092\u906e\u65ad\u3057\u3001PI3K-Akt\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u5fc3\u7b4b\u306b\u304a\u3051\u308b\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u306f\u5fc3\u81d3\u306e\u7cd6\u8102\u8cea\u4ee3\u8b1d\u3092\u8abf\u7bc0\u3059\u308b\u305f\u3081\u306e\u91cd\u8981\u306a\u6a19\u7684\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u6b21\u306b\u3001\u5fc3\u7b4b\u7cd6\u8102\u8cea\u4ee3\u8b1d\u306e\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u5f8c\u306e\u5fc3\u6a5f\u80fd\u3068\u6052\u5e38\u6027\u306e\u5909\u5316\u3092\u5206\u6790\u3057\u307e\u3057\u305f\u3002 Dox \u30e2\u30c7\u30eb\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u6cbb\u7642\u7fa4\u306e\u5fc3\u7b4b ATP \u7523\u751f\u306f\u6709\u610f\u306b\u5897\u52a0\u3057\u307e\u3057\u305f (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F5\/\" target=\"figure\" rel=\"noopener\">\u56f35A<\/a>)\u3001\u4e00\u65b9\u3001ROS \u304a\u3088\u3073 FAO \u306e\u4ee3\u8b1d\u7523\u7269\u3067\u3042\u308b MDA \u306e\u30ec\u30d9\u30eb\u306f\u5927\u5e45\u306b\u6e1b\u5c11\u3057\u307e\u3057\u305f (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F5\/\" target=\"figure\" rel=\"noopener\">\u56f35B\u3001E<\/a>\uff09\u3002 O2K \u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u5206\u6790\u306b\u3088\u308a\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c Dox \u66dd\u9732\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u5fc3\u81d3\u9178\u7d20\u6d88\u8cbb\u91cf\u306e\u5287\u7684\u306a\u5897\u52a0\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F5\/\" target=\"figure\" rel=\"noopener\">\u56f35C<\/a>\uff09\u3001ATP\u751f\u6210\/\u9178\u7d20\u6d88\u8cbb\u6bd4\u304c\u5927\u5e45\u306b\u6e1b\u5c11\u3057\u307e\u3057\u305f\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F5\/\" target=\"figure\" rel=\"noopener\">\u56f35D<\/a>)\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u819c\u96fb\u4f4d\u3092\u6b63\u898f\u5316\u3057\u307e\u3057\u305f (<a class=\"sec\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#s11\">\u88dc\u8db3\u56f3S4<\/a>\uff09\u3002\u3053\u308c\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u6cbb\u7642\u304c\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u52b9\u7387\u306e\u9ad8\u3044\u30b0\u30eb\u30b3\u30fc\u30b9\u3092\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\u3068\u3057\u3066\u4f7f\u7528\u3059\u308b\u5fc3\u7b4b\u306e\u80fd\u529b\u3092\u9ad8\u3081\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002 ATP\u751f\u7523\u306e\u52b9\u7387\u3092\u5411\u4e0a\u3055\u305b\u307e\u3059\u3002\u5fc3\u81d3\u306e\u8ca0\u8377\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3001\u5fc3\u7b4b\u306e\u9178\u7d20\u6d88\u8cbb\u91cf\u3092\u8efd\u6e1b\u3057\u307e\u3059\u3002\u7d50\u8ad6\u3068\u3057\u3066\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001\u30bb\u30ed\u30c8\u30cb\u30f3-\u8840\u7cd6-\u5fc3\u7b4bAKT\u30eb\u30fc\u30d7\u3092\u8abf\u7bc0\u3057\u3001\u5fc3\u7b4b\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3092\u6539\u9020\u3057\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u5229\u7528\u3092\u5897\u52a0\u3055\u305b\u3001FAO\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u3001Dox\u66dd\u9732\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u5fc3\u81d3\u5185\u306e\u9ad8\u3044\u9178\u7d20\u6d88\u8cbb\u7387\u3068\u4e0d\u9069\u5207\u306a\u8102\u8cea\u71c3\u713c\u306e\u60aa\u5faa\u74b0\u3092\u52b9\u679c\u7684\u306b\u65ad\u3061\u5207\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F5\/\" target=\"figure\" rel=\"noopener\">\u56f35F<\/a>\uff09\u3001DIC\u306e\u3055\u3089\u306a\u308b\u9032\u884c\u3092\u9632\u304e\u307e\u3059\u3002<\/p>\n<div id=\"F5\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm139983197130224\">\n<div class=\"ts_bar small\" title=\"\u753b\u50cf\u3092\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u3057\u307e\u3059\"><\/div>\n<p><a class=\"inline_block ts_canvas\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/core\/lw\/2.0\/html\/tileshop_pmc\/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&amp;p=PMC3&amp;id=9551275_fphar-13-930835-g005.jpg\" target=\"tileshopwindow\" rel=\"noopener\"><img decoding=\"async\" class=\"tileshop\" title=\"\u753b\u50cf\u3092\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u3057\u307e\u3059\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/bin\/fphar-13-930835-g005.jpg\" alt=\"An external file that holds a picture, illustration, etc.Object name is fphar-13-930835-g005.jpg\" \/><\/a><\/div>\n<div id=\"lgnd_F5\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F5\/\" target=\"figure\" rel=\"noopener\">\u56f35<\/a><\/div>\n<div class=\"caption\">\n<p><strong>(A)<\/strong>\u00a0H9c2 \u7d30\u80de\u306e ATP \u542b\u6709\u91cf\u3002\u00a0<strong>(B)<\/strong>\u00a0H9c2 \u7d30\u80de\u306e MDA \u542b\u6709\u91cf\u3002\u00a0<strong>(C)<\/strong>\u00a0H9c2 \u7d30\u80de\u306e\u5fc3\u81d3\u9178\u7d20\u6d88\u8cbb\u91cf\u3002\u00a0<strong>(D)<\/strong>\u00a0H9c2\u7d30\u80de\u306b\u304a\u3051\u308bATP\u7523\u751f\/\u9178\u7d20\u6d88\u8cbb\u6bd4\u3002\u00a0<strong>(\u30db)<\/strong>\u00a0H9c2 \u7d30\u80de\u306b\u304a\u3051\u308b ROS \u67d3\u8272\u306e\u5f37\u5ea6\u3002\u00a0<strong>(F)<\/strong>\u00a0\u56de\u8def\u56f3\u3002\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u5bfe\u30c9\u30c3\u30af\u30b9\u3001\u30d6\u30ec\u30d6\u5bfe\u30c9\u30c3\u30af\u30b9\u3001\u30c7\u30af\u30b9\u30e9\u5bfe\u30c9\u30c3\u30af\u30b9: ***<em>p<\/em>\u00a0&lt; 0.0005\u3001**<em>p<\/em>\u00a0&lt; 0.005\u3001*<em>p<\/em>\u00a0&lt; 0.05\u3001\u5e73\u5747\u00b1SD\u3002\u00a0<em>n<\/em>\u00a0= 6\u20139\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"s3-5\" class=\"sec\">\n<h3 id=\"s3-5title\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001PINK1\/Parkin \u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u901a\u3058\u3066\u3001Dox \u6cbb\u7642\u5f8c\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u640d\u50b7\u3092\u9664\u53bb\u3057\u3001\u5fc3\u7b4b\u6052\u5e38\u6027\u3092\u56de\u5fa9\u3057\u307e\u3059\u3002<\/h3>\n<p class=\"p p-first\">DIC \u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u3059\u308b\u4eee\u8aac\u306f\u904e\u53bb\u6570\u5341\u5e74\u306b\u308f\u305f\u3063\u3066\u5909\u5316\u3057\u3066\u304d\u307e\u3057\u305f\u304c\u3001DIC \u306e\u4e3b\u306a\u7279\u5fb4\u306f\u9178\u5316\u9084\u5143\u4e0d\u5747\u8861\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u306e\u969c\u5bb3\u3067\u3059\u3002\u3053\u306e\u7d50\u679c\u306f\u3001\u5fc3\u81d3\u30a8\u30cd\u30eb\u30ae\u30fc\u6bd4\u3068\u30a8\u30cd\u30eb\u30ae\u30fc\u51fa\u529b\u52b9\u7387\u306e\u89b3\u70b9\u304b\u3089DIC\u767a\u75c7\u306e\u4ee5\u524d\u306e\u4eee\u8aac\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u3092\u59a8\u3052\u305f\u304c\u3001\u91cd\u8981\u306a\u7591\u554f\u3001\u3059\u306a\u308f\u3061\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5f8c\u306e\u5fc3\u81d3\u306e\u4ee3\u8b1d\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3092\u6700\u9069\u5316\u3059\u308b\u3053\u3068\u3067\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u52b9\u7387\u7684\u306a\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u3068\u5fc3\u81d3\u5fae\u5c0f\u74b0\u5883\u6052\u5e38\u6027\u3092\u9054\u6210\u3059\u308b\u306e\u304b\u3068\u3044\u3046\u91cd\u8981\u306a\u7591\u554f\u3092\u63d0\u8d77\u3057\u305f\u3002\u3051\u304c\u3002\u305d\u3053\u3067\u3001\u79c1\u305f\u3061\u306f\u3053\u306e\u8cea\u554f\u306b\u7b54\u3048\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u307e\u3057\u305f\u3002 Pten \u8a98\u5c0e\u6027\u306e\u63a8\u5b9a\u30ad\u30ca\u30fc\u30bc 1 PINK1\/Parkin \u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306b\u3088\u3063\u3066\u5a92\u4ecb\u3055\u308c\u308b\u4e3b\u8981\u306a\u7d4c\u8def\u306e 1 \u3064\u3067\u3042\u308a\u3001\u5fc3\u7b4b\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306e\u7dad\u6301\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B7\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30c7\u30ef\u30f3\u30b8\u30fc\u307b\u304b\u30012021<\/a>\uff09\u3002\u5fc3\u7b4b\u7d30\u80de\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u640d\u50b7\u3059\u308b\u3068\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u54c1\u8cea\u7ba1\u7406\u30b7\u30b9\u30c6\u30e0\u306e\u300c\u756a\u5175\u300d\u3067\u3042\u308bPINK1\u304c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5916\u819c\u306b\u84c4\u7a4d\u3057\u3001\u30d1\u30fc\u30ad\u30f3\u3092\u96c6\u3081\u3066\u30ea\u30f3\u9178\u5316\u3057\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B33\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30d7\u30fc\u30eb\u3068\u30de\u30af\u30e9\u30a6\u30c9\u30012021<\/a>\uff09\u3002\u6d3b\u6027\u5316\u3055\u308c\u305fParkin\u306f\u640d\u50b7\u3057\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u3057\u3001\u305d\u306e\u5f8c\u30ea\u30bd\u30bd\u30fc\u30e0\u3068\u878d\u5408\u3057\u3066\u5b8c\u5168\u306b\u5206\u89e3\u3057\u307e\u3059\u3002 PINK1\/Parkin \u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306b\u3088\u3063\u3066\u5a92\u4ecb\u3055\u308c\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u5f37\u5316\u306f\u3001\u5fc3\u7b4b\u7d30\u80de\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6052\u5e38\u6027\u3092\u7dad\u6301\u3057\u3001\u5fc3\u81d3\u75c5\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B8\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30c9\u30fc\u30f3\u30012016<\/a>).<\/p>\n<p>\u3057\u305f\u304c\u3063\u3066\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306fPINK1\/\u30d1\u30fc\u30ad\u30f3\u7d4c\u8def\u3092\u901a\u3058\u3066\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u5f37\u5316\u3057\u3001\u5fc3\u7b4b\u7d30\u80de\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6052\u5e38\u6027\u3092\u7dad\u6301\u3059\u308b\u3068\u63a8\u6e2c\u3057\u307e\u3057\u305f\u3002 WB\u306f\u3001Dox\u30b0\u30eb\u30fc\u30d7\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u6cbb\u7642\u30b0\u30eb\u30fc\u30d7\u306ePINK1\/Parkin\u306e\u7dcf\u30bf\u30f3\u30d1\u30af\u8cea\u767a\u73fe\u30ec\u30d9\u30eb\u304c\u6709\u610f\u306b\u5897\u52a0\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\u56f36A<\/a>)\u3001\u5bfe\u5fdc\u3059\u308b\u30ea\u30f3\u9178\u5316\u30ec\u30d9\u30eb\u3082\u5927\u5e45\u306b\u5897\u52a0\u3057\u307e\u3057\u305f (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\u56f36B<\/a>\uff09\u3002 Dox \u6cbb\u7642\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001PINK1\/Parkin \u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u304c\u6e1b\u5c11\u50be\u5411\u3092\u793a\u3057\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ea\u30f3\u9178\u5316\u304c\u5927\u5e45\u306b\u6e1b\u5c11\u3059\u308b\u4e00\u65b9\u3067\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u819c\u30bf\u30f3\u30d1\u30af\u8cea Tom20 \u306e\u30ec\u30d9\u30eb\u304c\u5897\u52a0\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001Dox \u304c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u640d\u50b7\u3092\u8a98\u767a\u3057\u305f\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u640d\u50b7\u3057\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u9069\u6642\u306e\u9664\u53bb\u3092\u963b\u5bb3\u3057\u305f\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3002 Dox \u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u591a\u6570\u306e\u58ca\u308c\u3066\u640d\u50b7\u3057\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f (\u8d64\u3044\u77e2\u5370\u3001\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\u56f36D<\/a>)\u3001\u4e00\u65b9\u3001Brev \u30b0\u30eb\u30fc\u30d7\u3067\u306f\u5927\u91cf\u306e\u30ea\u30bd\u30bd\u30fc\u30e0\u306b\u5305\u307e\u308c\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2 \u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f (\u9752\u3044\u77e2\u5370)\u3002 Dox \u3068 Brev \u3092\u540c\u6642\u306b\u9069\u7528\u3057\u305f\u5834\u5408\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u9686\u8d77\u306f\u660e\u767d\u3067\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5f62\u614b\u306f\u6b63\u5e38\u3067\u3001\u819c\u69cb\u9020\u306f\u7121\u50b7\u3067\u3057\u305f\u3002 MitoTracker \u3067\u67d3\u8272\u3059\u308b\u3068\u3001Dox \u30b0\u30eb\u30fc\u30d7\u3067\u6700\u3082\u9ad8\u3044\u86cd\u5149\u5f37\u5ea6\u304c\u898b\u3064\u304b\u308a\u307e\u3057\u305f (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\u56f36C<\/a>\uff09\u3001Dox \u30b0\u30eb\u30fc\u30d7\u306b\u306f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304a\u3088\u3073 Brev \u30b0\u30eb\u30fc\u30d7\u3088\u308a\u3082\u6709\u610f\u306b\u591a\u304f\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u3042\u3063\u305f\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u6297\u9178\u5316\u30bf\u30f3\u30d1\u30af\u8cea NADH \u304a\u3088\u3073 SOD \u306e\u30ec\u30d9\u30eb\u306f\u3001Brev \u6cbb\u7642\u5f8c\u306b\u5927\u5e45\u306b\u5897\u52a0\u3057\u307e\u3057\u305f (<a class=\"sec\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#s11\">\u88dc\u8db3\u56f3S5<\/a>\uff09\u3002\u30a8\u30cd\u30eb\u30ae\u30fc\u53d7\u5bb9\u4f53AMPK\u306e\u30ea\u30f3\u9178\u5316\u306f\u3001Dox\u30b0\u30eb\u30fc\u30d7\u3068\u6bd4\u8f03\u3057\u3066Brev\u6cbb\u7642\u30b0\u30eb\u30fc\u30d7\u3067\u5927\u5e45\u306b\u6e1b\u5c11\u3057\u307e\u3057\u305f\u304c\u3001\u7d30\u80de\u5897\u6b96\u5236\u5fa1\u4e2d\u67a2\u306f\u6d3b\u6027\u5316\u3055\u308c\u307e\u3057\u305f\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\u56f36E<\/a>\uff09\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001Dox \u66dd\u9732\u304c\u5fc3\u7b4b\u640d\u50b7\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u84c4\u7a4d\u3001\u6052\u5e38\u6027\u4e0d\u5747\u8861\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u306f Dox \u6295\u4e0e\u5f8c\u306b\u5fc3\u81d3\u30a8\u30cd\u30eb\u30ae\u30fc\u51fa\u529b\u52b9\u7387\u304c\u4f4e\u4e0b\u3057\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u5897\u52a0\u3059\u308b\u7406\u7531\u3092\u3042\u308b\u7a0b\u5ea6\u8aac\u660e\u3057\u307e\u3059\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u4fc3\u9032\u3057\u3001\u640d\u50b7\u3057\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u9664\u53bb\u3057\u3001\u5fc3\u7b4b\u306e\u6052\u5e38\u6027\u3092\u56de\u5fa9\u3057\u3001\u5fc3\u81d3 ATP \u7523\u751f\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u9593\u306e\u52d5\u7684\u306a\u30d0\u30e9\u30f3\u30b9\u3092\u52b9\u679c\u7684\u306b\u78ba\u4fdd\u3057\u307e\u3059\u3002<\/p>\n<div id=\"F6\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm139983210526288\">\n<div class=\"ts_bar small\" title=\"\u753b\u50cf\u3092\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u3057\u307e\u3059\"><\/div>\n<p><a class=\"inline_block ts_canvas\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/core\/lw\/2.0\/html\/tileshop_pmc\/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&amp;p=PMC3&amp;id=9551275_fphar-13-930835-g006.jpg\" target=\"tileshopwindow\" rel=\"noopener\"><img decoding=\"async\" class=\"tileshop\" title=\"\u753b\u50cf\u3092\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u3057\u307e\u3059\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/bin\/fphar-13-930835-g006.jpg\" alt=\"An external file that holds a picture, illustration, etc.Object name is fphar-13-930835-g006.jpg\" \/><\/a><\/div>\n<div id=\"lgnd_F6\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\u56f36<\/a><\/div>\n<div class=\"caption\">\n<p><strong>(A)<\/strong>\u00a0PINK1\u3001Parkin\u3001Tom20\u3001GAPDH\u306e\u767a\u73fe\u30ec\u30d9\u30eb\u3092\u6e2c\u5b9a\u3057\u307e\u3057\u305f\u00a0<em>\u8a66\u9a13\u7ba1\u5185\u3067<\/em>\u00a0WB\u8457\u3002\u00a0<strong>(B)<\/strong>\u00a0p-PINK1\u3001p-Parkin\u3001\u304a\u3088\u3073 Tom20 \u306e\u767a\u73fe\u30ec\u30d9\u30eb\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002\u00a0<strong>(C)<\/strong>\u00a0\u30df\u30c8\u30c8\u30ec\u30fc\u30b5\u30fc\u67d3\u8272\u3002\u00a0<strong>(D)<\/strong>\u00a0\u96fb\u5b50\u9855\u5fae\u93e1\u6cd5\u3002\u00a0<strong>(\u30db)<\/strong>\u00a0p-AMPK\u3001p-mTOR\u3001p-Akt\u3001\u304a\u3088\u3073p-PI3K\u306e\u767a\u73fe\u30ec\u30d9\u30eb\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002\u00a0<strong>(F)<\/strong>\u00a0Mdivi-1 \u3092\u88dc\u5145\u3057\u305f\u5f8c\u306e H9c2 \u7d30\u80de\u306b\u304a\u3051\u308b ROS \u67d3\u8272\u306e\u5f37\u5ea6\u3002\u00a0<strong>(G)<\/strong>\u00a0Mdivi-1 \u3092\u88dc\u7d66\u3057\u305f\u5f8c\u306e H9c2 \u7d30\u80de\u306e ATP \u542b\u6709\u91cf\u3002<strong>(H)<\/strong>\u00a0p-AMPK\/t-AMPK\u3001p-mTOR\/t-mTOR\u3001p-Akt\/t-Akt\u3001\u304a\u3088\u3073 p-PI3K\/t-PI3K \u306e\u68d2\u30b0\u30e9\u30d5\u3002\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u5bfe Dox\u3001Dox + Mdivi-1 \u5bfe Dox\u3001\u304a\u3088\u3073 Dox + Brev + Mdivi-1 \u5bfe Dox + Brev: ***<em>p<\/em>\u00a0&lt; 0.0005\u3001**<em>p<\/em>\u00a0&lt; 0.005\u3001*<em>p<\/em>\u00a0&lt; 0.05\u3001\u5e73\u5747\u00b1SD\u3002\u00a0<em>n<\/em>\u00a0= 6\u20139\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p class=\"p p-last\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u3053\u306e\u52b9\u679c\u304c Mdivi-1 \u306b\u3088\u3063\u3066\u30d6\u30ed\u30c3\u30af\u3055\u308c\u308b\u3068\u3001\u5fc3\u7b4b\u7d30\u80de\u306e ROS \u30ec\u30d9\u30eb\u304c\u5927\u5e45\u306b\u5897\u52a0\u3057\u307e\u3057\u305f (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\u56f36F<\/a>)\u3001\u4e00\u65b9\u3001ATP \u751f\u7523\u306f\u5927\u5e45\u306b\u6e1b\u5c11\u3057\u307e\u3057\u305f (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\u56f36G<\/a>\uff09\u3002\u3055\u3089\u306b\u3001\u5fc3\u7b4b\u7d30\u80de\u306e\u751f\u5b58\u7387\u3082\u4f4e\u4e0b\u3057\u307e\u3057\u305f\uff08<a class=\"sec\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#s11\">\u88dc\u8db3\u56f3S6<\/a>\uff09\u3001\u5fc3\u7b4b\u7d30\u80de\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u4fee\u5fa9\u52b9\u679c\u306f\u963b\u5bb3\u3055\u308c\u307e\u3057\u305f\u3002 Dox \u3068 Mdivi-1 \u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3068\u3001ATP \u7523\u751f\u3068\u5fc3\u7b4b\u7d30\u80de\u306e\u751f\u5b58\u7387\u304c\u3055\u3089\u306b\u4f4e\u4e0b\u3057\u3001ROS \u30ec\u30d9\u30eb\u304c\u4e0a\u6607\u3057\u3001\u5fc3\u7b4b\u640d\u50b7\u304c\u60aa\u5316\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2 \u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u304c Dox \u8a98\u767a\u6027\u5fc3\u7b4b\u7d30\u80de\u50b7\u5bb3\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u5fc3\u81d3\u306e\u4ee3\u8b1d\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u518d\u69cb\u7bc9\u3060\u3051\u3067\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u640d\u50b7\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u6a5f\u80fd\u4e0d\u5168\u3092\u5b8c\u5168\u306b\u76f8\u6bba\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u305a\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u5fc3\u7b4b\u4fdd\u8b77\u52b9\u679c\u306f\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u304a\u3088\u3073\u8102\u8cea\u4ee3\u8b1d\u306e\u8abf\u7bc0\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u6d3b\u6027\u5316\u306b\u4f9d\u5b58\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u5fc3\u81d3\u4ee3\u8b1d\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u8abf\u7bc0\u304c DIC \u767a\u75c7\u306e\u4eee\u8aac\u306b\u95a2\u3057\u3066\u8003\u616e\u3055\u308c\u3066\u3044\u306a\u3044\u7406\u7531\u3067\u3082\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002 Dox \u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u5fc3\u6a5f\u80fd\u4e0d\u5168\u304a\u3088\u3073\u5fc3\u4e0d\u5168\u306e\u75c7\u72b6\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u306f\u3001\u75c5\u6c17\u306e\u9032\u884c\u306e\u4e88\u9632\u3068\u5fc3\u6a5f\u80fd\u306e\u56de\u5fa9\u304c\u540c\u69d8\u306b\u91cd\u8981\u3067\u3042\u308b\u306f\u305a\u3067\u3042\u308a\u3001\u305d\u306e\u65b9\u304c\u60a3\u8005\u306e\u4e88\u5f8c\u3068\u751f\u6d3b\u306e\u8cea\u306b\u3068\u3063\u3066\u3088\u308a\u6709\u76ca\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n<div id=\"s3-6\" class=\"sec sec-last\">\n<h3 id=\"s3-6title\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001Dox \u6295\u4e0e\u5f8c\u306e\u708e\u75c7\u3092\u8efd\u6e1b\u3057\u3001\u514d\u75ab\u6291\u5236\u7d30\u80de\u6d78\u6f64\u3092\u8efd\u6e1b\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u4e73\u304c\u3093\u306e\u5316\u5b66\u7642\u6cd5\u3068\u76f8\u4e57\u52b9\u679c\u3092\u767a\u63ee\u3057\u307e\u3059\u3002<\/h3>\n<p class=\"p p-first\">\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u8d77\u6e90\u8aac\u306b\u3088\u308c\u3070\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u597d\u6c17\u6027\u7d30\u83cc\u306e\u878d\u5408\u306b\u7531\u6765\u3057\u3066\u304a\u308a\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u306f\u5916\u6765\u306e\u6027\u8cea\u304c\u3042\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B11\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30b0\u30ec\u30fc\u30012012<\/a>\uff09\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u640d\u50b7\u3059\u308b\u3068\u3001\u640d\u50b7\u95a2\u9023\u5206\u5b50\u30d1\u30bf\u30fc\u30f3 (DAMP) \u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u3001\u4f53\u306e\u514d\u75ab\u53cd\u5fdc\u304c\u6d3b\u6027\u5316\u3055\u308c\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B49\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30a6\u30a3\u30eb\u30ad\u30f3\u30b9\u3089\u30012017<\/a>\uff09\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u640d\u50b7\u3057\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u9664\u53bb\u3092\u4fc3\u9032\u3057\u3001\u708e\u75c7\u3092\u8efd\u6e1b\u3059\u308b\u306e\u306b\u5f79\u7acb\u3064\u3068\u3044\u3046\u4eee\u8aac\u3092\u7acb\u3066\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3042\u308b\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-1\u03b2\uff08IL-1\u03b2\uff09\u3001IL-6\u3001\u304a\u3088\u3073\u816b\u760d\u58ca\u6b7b\u56e0\u5b50\u03b1\uff08TNF-\u03b1\uff09\u306e\u8840\u6e05\u30ec\u30d9\u30eb\u304c\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u4ecb\u5165\u5f8c\u306b\u6709\u610f\u306b\u6e1b\u5c11\u3057\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F7\/\" target=\"figure\" rel=\"noopener\">\u56f37A<\/a>)\u3001\u5fc3\u81d3\u7d44\u7e54\u306e\u514d\u75ab\u67d3\u8272\u3067\u306f\u3001IL-1\u03b2 \u304c\u4f4e\u30ec\u30d9\u30eb\u3067\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f (<a class=\"sec\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#s11\">\u88dc\u8db3\u56f3S7<\/a>\uff09\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u708e\u75c7\u56e0\u5b50\u306e\u5206\u6ccc\u3092\u6e1b\u5c11\u3055\u305b\u3001Dox \u306b\u66dd\u9732\u3055\u308c\u305f\u30de\u30a6\u30b9\u306e\u708e\u75c7\u53cd\u5fdc\u3092\u8efd\u6e1b\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u708e\u75c7\u8abf\u7bc0\u56e0\u5b50\u3068\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u7d30\u80de\u306f\u816b\u760d\u5fae\u5c0f\u74b0\u5883\u306e\u91cd\u8981\u306a\u69cb\u6210\u8981\u7d20\u3067\u3042\u308a\u3001\u708e\u75c7\u3068\u816b\u760d\u306e\u95a2\u4fc2\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B9\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30a8\u30ea\u30ca\u30d5\u3089\u30012013<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B36\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30bd\u30fc\u30c6\u30b9\u30fb\u30d5\u30ea\u30c3\u30c9\u30de\u30f3\u3089\u30012019<\/a>\uff09\u3002\u816b\u760d\u5fae\u5c0f\u74b0\u5883\u306b\u304a\u3051\u308b\u708e\u75c7\u306b\u306f\u3055\u307e\u3056\u307e\u306a\u524d\u816b\u760d\u52b9\u679c\u304c\u3042\u308a\u3001\u60aa\u6027\u7d30\u80de\u306e\u5897\u6b96\u3068\u751f\u5b58\u3001\u8840\u7ba1\u65b0\u751f\u3001\u8ee2\u79fb\u3092\u4fc3\u9032\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4f53\u306e\u7372\u5f97\u514d\u75ab\u53cd\u5fdc\u3092\u5f31\u3081\u308b\u3002\u30db\u30eb\u30e2\u30f3\u3084\u5316\u5b66\u7642\u6cd5\u85ac\u306b\u5bfe\u3059\u308b\u4f53\u306e\u53cd\u5fdc\u3092\u5909\u5316\u3055\u305b\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B14\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30a2\u30a4\u30a2\u30f3\u30ac\u30fc\u4ed6\u30012016<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B28\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30de\u30f3\u3068\u30e1\u30e9\u30fc\u30012016<\/a>\uff09\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306fDox\u6cbb\u7642\u5f8c\u306e\u708e\u75c7\u3092\u8efd\u6e1b\u3057\u305f\u304c\u3001\u4e73\u304c\u3093\u7d30\u80de\u306b\u5bfe\u3059\u308bDox\u306e\u6bba\u50b7\u52b9\u679c\u306b\u306f\u5f71\u97ff\u3092\u4e0e\u3048\u306a\u304b\u3063\u305f\u00a0<em>\u8a66\u9a13\u7ba1\u5185\u3067<\/em>\u00a0(<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F7\/\" target=\"figure\" rel=\"noopener\">\u56f37B<\/a>\uff09\u3002\u7279\u306b\u816b\u760d\u95a2\u9023\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8 (TAM) \u306e\u5171\u540c\u6cbb\u7642\u306b\u304a\u3044\u3066\u3001\u816b\u760d\u75c5\u5de3\u3078\u306e\u708e\u75c7\u7d30\u80de\u306e\u79fb\u52d5\u306e\u9632\u6b62\u306b\u5f79\u7acb\u3064\u304b\u3069\u3046\u304b\u306f\u4e0d\u660e\u306e\u307e\u307e\u3067\u3059\u3002 TAM \u306f\u91cd\u8981\u306a\u6d78\u6f64\u514d\u75ab\u7d30\u80de\u3067\u3042\u308a\u3001\u4e73\u304c\u3093\u306e\u816b\u760d\u7d30\u80de\u306e 50% \u306e\u539f\u56e0\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30de\u30a6\u30b9\u304a\u3088\u3073\u30d2\u30c8\u306e\u816b\u760d\u306b\u304a\u3051\u308b TAM \u304a\u3088\u3073\u95a2\u9023\u7d30\u80de\u306f\u901a\u5e38 M2 \u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3067\u3042\u308a\u3001\u816b\u760d\u306e\u5897\u6b96\u3068\u8840\u7ba1\u65b0\u751f\u3092\u4fc3\u9032\u3057\u3001\u6cbb\u7642\u62b5\u6297\u6027\u3092\u9ad8\u3081\u3001\u7372\u5f97\u514d\u75ab\u3092\u963b\u5bb3\u3057\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B6\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30c1\u30a7\u30f3\u4ed6\u30012019<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B32\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30d1\u30f3\u3089\u30012020<\/a>\uff09\u3002 TAM \u6d78\u6f64\u307e\u305f\u306f\u85ac\u7269\u8a98\u767a\u6027\u306e TAM \u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u3092\u8efd\u6e1b\u3059\u308b\u3053\u3068\u306f\u3001\u816b\u760d\u514d\u75ab\u7642\u6cd5\u306e\u65b0\u305f\u306a\u6226\u7565\u3067\u3059\u3002\u305d\u3053\u3067\u30014T1 \u4e73\u304c\u3093\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3092\u69cb\u7bc9\u3057\u307e\u3057\u305f (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F7\/\" target=\"figure\" rel=\"noopener\">\u56f37C<\/a>\uff09\u3002 4T1\u816b\u760d\u3092\u6709\u3059\u308b\u30de\u30a6\u30b9\u00a0<em>\u73fe\u5834\u3067<\/em>\u00a0(200mm<sup>3<\/sup>) \u3092\u30e9\u30f3\u30c0\u30e0\u306b 3 \u3064\u306e\u30b0\u30eb\u30fc\u30d7 (<em>n<\/em>\u00a0= 5)\u3001\u30ea\u30f3\u9178\u7de9\u885d\u751f\u7406\u98df\u5869\u6c34 (PBS)\u3001Dox\u3001\u307e\u305f\u306f Dox + Brev \u3092\u6ce8\u5c04\u3057\u307e\u3059\u3002 Dox \u3068 Brev \u306f 10 mgkg \u306e\u7528\u91cf\u3067\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f<sup>\u22121<\/sup>\u00a0\u4f53\u91cd\u30681.4 mgkg<sup>\u22121<\/sup>\u00a0\u305d\u308c\u305e\u308c\u4f53\u91cd\u3002\u51e6\u7f6e\u306e7\u65e5\u5f8c\u306b\u30de\u30a6\u30b9\u3092\u5c60\u6bba\u3057\u3001FCM\u304a\u3088\u3073\u7d44\u7e54\u5b66\u7684\u8a55\u4fa1\u306e\u305f\u3081\u306b\u816b\u760d\u3092\u53ce\u96c6\u3057\u305f\u3002 Dox + Brev \u6cbb\u7642\u5f8c\u3001\u816b\u760d\u306b\u6d78\u6f64\u3059\u308b\u816b\u760d\u95a2\u9023\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8 (TAM) \u306e\u5272\u5408\u304c\u6e1b\u5c11\u3057\u307e\u3057\u305f (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F7\/\" target=\"figure\" rel=\"noopener\">\u56f37D<\/a>\uff09\u3002\u816b\u760d\u7d44\u7e54\u306e\u7d44\u7e54\u5b66\u7684\u67d3\u8272\u3067\u306f\u3001M2 \u8868\u73fe\u578b\u30de\u30fc\u30ab\u30fc CD206 \u306e\u767a\u73fe\u304c\u6709\u610f\u306b\u4f4e\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F7\/\" target=\"figure\" rel=\"noopener\">\u56f37E<\/a>\uff09\u3002 Dox + Brev \u3067\u6cbb\u7642\u3057\u305f\u30de\u30a6\u30b9\u306e\u816b\u760d\u4f53\u7a4d\u306f\u3001Dox \u5358\u72ec\u3067\u6cbb\u7642\u3057\u305f\u30de\u30a6\u30b9\u306e\u816b\u760d\u4f53\u7a4d\u3088\u308a\u3082\u6709\u610f\u306b\u5c0f\u3055\u304b\u3063\u305f (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F7\/\" target=\"figure\" rel=\"noopener\">\u56f37F<\/a>\uff09\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u708e\u75c7\u3068 TAM \u6d78\u6f64\u3092\u8efd\u6e1b\u3059\u308b\u3053\u3068\u3067\u816b\u760d\u306e\u5897\u6b96\u3092\u6291\u5236\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<div id=\"F7\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm139983202323296\">\n<div class=\"ts_bar small\" title=\"\u753b\u50cf\u3092\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u3057\u307e\u3059\"><\/div>\n<p><a class=\"inline_block ts_canvas\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/core\/lw\/2.0\/html\/tileshop_pmc\/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&amp;p=PMC3&amp;id=9551275_fphar-13-930835-g007.jpg\" target=\"tileshopwindow\" rel=\"noopener\"><img decoding=\"async\" class=\"tileshop\" title=\"\u753b\u50cf\u3092\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u62e1\u5927\u3057\u307e\u3059\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/bin\/fphar-13-930835-g007.jpg\" alt=\"An external file that holds a picture, illustration, etc.Object name is fphar-13-930835-g007.jpg\" \/><\/a><\/div>\n<div id=\"lgnd_F7\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F7\/\" target=\"figure\" rel=\"noopener\">\u56f37<\/a><\/div>\n<div class=\"caption\">\n<p><strong>(A)<\/strong>\u00a0\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3 IL-1\u03b2\u3001IL-6\u3001\u304a\u3088\u3073 TNF-\u03b1 \u306e\u8840\u6e05\u30ec\u30d9\u30eb\u3002\u00a0<strong>(B)<\/strong>\u00a0MCF-7\u7d30\u80de\u306e\u751f\u5b58\u7387\u00a0<em>\u8a66\u9a13\u7ba1\u5185\u3067<\/em>.\u00a0<strong>(C)<\/strong>\u00a0\u816b\u760d\u3092\u6709\u3059\u308b\u30de\u30a6\u30b9\u306e\u6cbb\u7642\u306e\u6982\u7565\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u3002\u00a0<strong>(D)<\/strong>\u00a0FCM \u306e\u305f\u3081\u306b\u30de\u30a6\u30b9\u816b\u760d\u3092\u53ce\u96c6\u3057\u307e\u3057\u305f\u3002\u00a0<strong>(\u30db)<\/strong>\u00a0M2 \u8868\u73fe\u578b\u30de\u30fc\u30ab\u30fc CD206 \u306b\u95a2\u3059\u308b\u816b\u760d\u306e\u7d44\u7e54\u5b66\u7684\u67d3\u8272\u3002\u00a0<strong>(F)<\/strong>\u00a0\u816b\u760d\u91cf\u306e\u5408\u8a08\u306e\u5e73\u5747\u3002 *<em>p<\/em>\u00a0&lt; 0.0005\u3002\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u5bfe\u30c9\u30c3\u30af\u30b9\u3001\u30c7\u30af\u30b9\u30e9\u5bfe\u30c9\u30c3\u30af\u30b9\u3001\u30d6\u30ec\u30d6\u5bfe\u30c9\u30c3\u30af\u30b9: ***<em>p<\/em>\u00a0&lt; 0.0005\u3001**<em>p<\/em>\u00a0&lt; 0.005\u3001*<em>p<\/em>\u00a0&lt; 0.05\u3001\u5e73\u5747\u00b1SD\u3002\u00a0<em>n<\/em>\u00a0= 6\u20139\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"s4\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"s4title\" class=\"head no_bottom_margin ui-helper-clearfix\">\u8b70\u8ad6<\/h2>\n<p class=\"p p-first\">\u3053\u306e\u7814\u7a76\u306f\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u3068\u8102\u8cea\u306e\u4ee3\u8b1d\u6a5f\u80fd\u969c\u5bb3\u304c\u30a2\u30f3\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u8a98\u767a\u6027\u5fc3\u6bd2\u6027\u306e\u91cd\u8981\u306a\u539f\u52d5\u529b\u3067\u3042\u308b\u3053\u3068\u3001\u5fc3\u81d3\u4ee3\u8b1d\u306e\u56de\u5fa9\u3001\u5fc3\u7b4b\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u306e\u4fc3\u9032\u3001\u5fc3\u7b4b\u30a8\u30cd\u30eb\u30ae\u30fc\u51fa\u529b\u52b9\u7387\u306e\u6539\u5584\u304cDox\u306e\u5fc3\u81d3\u526f\u4f5c\u7528\u3092\u4e88\u9632\u3059\u308b\u52b9\u679c\u7684\u306a\u65b9\u6cd5\u3067\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002\u3053\u308c\u3089\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3001\u3064\u307e\u308a\u640d\u50b7\u3057\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u9664\u53bb\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u708e\u75c7\u3092\u8efd\u6e1b\u3059\u308b\u3068\u3001Dox \u306e\u6297\u304c\u3093\u52b9\u679c\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002<\/p>\n<p>\u54fa\u4e73\u985e\u306e\u5fc3\u81d3\u306f\u7d99\u7d9a\u7684\u306a\u53ce\u7e2e\u306b\u5927\u91cf\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u4f7f\u7528\u3057\u3001ATP \u751f\u6210\u3068\u5fc3\u81d3\u53ce\u7e2e\u306e\u9593\u306e\u7dca\u5bc6\u306a\u9023\u643a\u306f\u9069\u5207\u306a\u5fc3\u81d3\u6a5f\u80fd\u306b\u4e0d\u53ef\u6b20\u3067\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B3\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30d9\u30eb\u30c6\u30ed\u3068\u30de\u30a2\u30c3\u30af\u30012018<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B44\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30c6\u30a3\u30e0\u4ed6\u30012018<\/a>\uff09\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u306f\u3001\u5fc3\u81d3\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306b\u3088\u308b\u6b63\u78ba\u306a\u5236\u5fa1\u304c\u5fc5\u8981\u3067\u3059\u3002\u3053\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u6700\u3082\u9855\u8457\u306a\u7279\u5fb4\u306f\u3001\u767a\u9054\u306e\u5909\u5316\u3084\u6804\u990a\u72b6\u614b\u306a\u3069\u306e\u3055\u307e\u3056\u307e\u306a\u523a\u6fc0\u306b\u53cd\u5fdc\u3059\u308b\u4ee3\u8b1d\u306e\u67d4\u8edf\u6027\u3068\u3001\u6162\u6027\u306e\u75c5\u614b\u751f\u7406\u5b66\u7684\u6761\u4ef6\u4e0b\u3067\u5fc3\u7b4b\u30a8\u30cd\u30eb\u30ae\u30fc\u3068\u53ce\u7e2e\u6a5f\u80fd\u3092\u8abf\u7bc0\u3059\u308b\u305f\u3081\u306b\u4ee3\u8b1d\u7d4c\u8def\u3092\u518d\u5f62\u6210\u3059\u308b\u5fc3\u81d3\u306e\u80fd\u529b\u3067\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B3\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30d9\u30eb\u30c6\u30ed\u3068\u30de\u30a2\u30c3\u30af\u30012018<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B16\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30ad\u30e0\u4ed6\u30012018<\/a>\uff09\u3002\u3053\u306e\u4ee3\u8b1d\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u306f\u3001\u5fc3\u81d3\u6a5f\u80fd\u306e\u7dad\u6301\u306b\u5bc4\u4e0e\u3057\u305f\u308a\u3001\u75c5\u6c17\u306e\u9032\u884c\u3092\u52a0\u901f\u3057\u305f\u308a\u3057\u307e\u3059\u3002\u5fc3\u80a5\u5927\u3084\u5fc3\u4e0d\u5168\u306a\u3069\u306e\u5fc3\u81d3\u75be\u60a3\u306b\u95a2\u3059\u308b\u7814\u7a76\u306f\u6570\u591a\u304f\u3042\u308a\u307e\u3059\u304c\u3001DIC\u306b\u95a2\u3059\u308b\u7814\u7a76\u306f\u307b\u3068\u3093\u3069\u3042\u308a\u307e\u305b\u3093\u3002\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u306f\u3001DNA\u640d\u50b7\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u4e0d\u5168\u3001Ca\u3092\u5f15\u304d\u8d77\u3053\u3059ROS\u7523\u751f\u3068\u30c8\u30dd\u30a4\u30bd\u30e1\u30e9\u30fc\u30bcII-\u03b2\u30bf\u30fc\u30b2\u30c6\u30a3\u30f3\u30b0\u306b\u7126\u70b9\u3092\u5f53\u3066\u3066\u304d\u307e\u3057\u305f\u3002<sup>2+<\/sup>\u00a0\u53d6\u308a\u6271\u3044\u3092\u8aa4\u3063\u305f\u3002\u3057\u304b\u3057\u3001ROS \u3092\u9664\u53bb\u3059\u308b\u9244\u30ad\u30ec\u30fc\u30c8\u5264\u3084\u30c8\u30dd\u30a4\u30bd\u30e1\u30e9\u30fc\u30bc II-\u03b2 \u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\u3067\u3042\u308b dexra \u306f\u5927\u304d\u306a\u52b9\u679c\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u304c\u3067\u304d\u305a\u3001\u4ed6\u306e\u8981\u56e0\u3082\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002 Dox \u304c\u5fc3\u7b4b\u306e\u4ee3\u8b1d\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3092\u3069\u306e\u3088\u3046\u306b\u8abf\u7bc0\u3059\u308b\u306e\u304b\u3001\u3053\u306e\u4ee3\u8b1d\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u304c\u5fc3\u81d3\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u51fa\u529b\u52b9\u7387\u306b\u3069\u306e\u3088\u3046\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u306e\u304b\u3001Dox \u304c\u5fc3\u6bd2\u6027\u3092\u4fc3\u9032\u3059\u308b\u306e\u304b\u3069\u3046\u304b\u306f\u4f9d\u7136\u3068\u3057\u3066\u4e0d\u660e\u3067\u3059\u3002\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u8102\u8cea\u904e\u9178\u5316\u306e\u84c4\u7a4d\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u5fc3\u7b4b\u7d30\u80de\u306e\u30d5\u30a7\u30ed\u30c8\u30fc\u30b7\u30b9\u304c DIC \u306e\u9032\u884c\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u3001Dox \u306b\u66dd\u9732\u3055\u308c\u305f\u5fc3\u7b4b\u7d30\u80de\u306f\u8102\u8cea\u4ee3\u8b1d\u3092\u9ad8\u3081\u308b\u50be\u5411\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B52\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8b1d\u3089\u30012021<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B17\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5317\u65b9\u3089\u30012022<\/a>\uff09\u3002\u6211\u3005\u306e\u767a\u898b\u306f\u3001Dox \u8a98\u767a\u6027\u5fc3\u6bd2\u6027\u304c\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u304a\u3088\u3073\u8102\u8cea\u4ee3\u8b1d\u306e\u8abf\u7bc0\u4e0d\u5168\u3068\u3001\u305d\u306e\u7d50\u679c\u3068\u3057\u3066\u751f\u3058\u308b\u9178\u7d20\u6d88\u8cbb\u91cf\u306e\u5897\u52a0\u3001\u975e\u52b9\u7387\u7684\u306a\u30a8\u30cd\u30eb\u30ae\u30fc\u751f\u7523\u3001\u304a\u3088\u3073\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u30ec\u30d9\u30eb\u306e\u5897\u52a0\u3068\u3044\u3046\u60aa\u3057\u304d\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u30eb\u30fc\u30d7\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u3053\u3068\u3092\u3055\u3089\u306b\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n<p class=\"p p-last\">\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001\u4e2d\u56fd\u3067\u5fc3\u8840\u7ba1\u75be\u60a3\u304a\u3088\u3073\u8133\u8840\u7ba1\u75be\u60a3\u306e\u6cbb\u7642\u306b\u6700\u3082\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u53e4\u5178\u7684\u306a\u85ac\u5264\u3067\u3042\u308a\u3001\u4e2d\u56fd\u85ac\u5c40\u65b9\u304a\u3088\u3073\u56fd\u5bb6\u5fc5\u9808\u533b\u85ac\u54c1\u30ea\u30b9\u30c8\u306b\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u4e2d\u56fd\u306e\u75c5\u9662\u306e\u6551\u6025\u6cbb\u7642\u306b\u4e0d\u53ef\u6b20\u306a\u85ac\u5264\u3067\u3059\u3002\u79c1\u305f\u3061\u306e\u7814\u7a76\u3067\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u30bb\u30ed\u30c8\u30cb\u30f3-\u8840\u7cd6-\u5fc3\u7b4bAKT\u56de\u8def\u3092\u8abf\u7bc0\u3057\u3001\u5fc3\u7b4b\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3092\u518d\u69cb\u7bc9\u3057\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u5229\u7528\u3092\u5897\u52a0\u3055\u305b\u3001\u8102\u8cea\u9178\u5316\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u3001ATP\u751f\u6210\u52b9\u7387\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002 Dox \u66dd\u9732\u306b\u3088\u308b\u5fc3\u81d3\u5185\u306e\u5927\u91cf\u306e\u8102\u8cea\u306e\u4ee3\u8b1d\u4e0d\u5168\u306b\u3088\u308b ATP \u751f\u6210\u4f4e\u4e0b\u3001\u9178\u7d20\u6d88\u8cbb\u91cf\u306e\u5897\u52a0\u3001\u9ad8\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u5f71\u97ff\u3092\u7de9\u548c\u3057\u3001AMPK \u306e\u767a\u73fe\u3092\u6e1b\u5c11\u3055\u305b\u3001\u5fc3\u81d3\u3078\u306e\u904e\u5270\u306a\u8102\u8cea\u306e\u53d6\u308a\u8fbc\u307f\u306e\u60aa\u5faa\u74b0\u3092\u30d6\u30ed\u30c3\u30af\u3057\u307e\u3059\u3002\u5fc3\u7b4b\u3092\u640d\u50b7\u3057\u3001DIC \u306e\u767a\u75c7\u3092\u9045\u3089\u305b\u307e\u3059 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B19\" aria-expanded=\"false\" aria-haspopup=\"true\">\u30b3\u30eb\u30a6\u30a3\u30c3\u30c4\u3068\u30c6\u30a3\u30a2\u30f3\u30012011<\/a>\uff09\u3002\u3055\u3089\u306b\u3001\u6211\u3005\u306e\u7d50\u679c\u306f\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u304c\u8840\u7cd6\u3092\u8abf\u7bc0\u3059\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u88dc\u52a9\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3001\u75c5\u7684\u72b6\u614b\u4e0b\u3067\u5fc3\u81d3\u3084\u4ed6\u306e\u91cd\u8981\u306a\u81d3\u5668\u306b\u8840\u7cd6\u3092\u4f9b\u7d66\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u30bb\u30ed\u30c8\u30cb\u30f3\u306f\u8840\u7cd6\u8abf\u7bc0\u306b\u5bfe\u3057\u3066\u76f8\u53cd\u3059\u308b\u52b9\u679c\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3066\u8840\u7cd6\u5024\u3092\u4e0b\u3052\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\u809d\u81d3\u3084\u9aa8\u683c\u7b4b\u4ee5\u5916\u306e\u7d44\u7e54\u304c\u30d6\u30c9\u30a6\u7cd6\u3092\u5438\u53ce\u3057\u3066\u8840\u7cd6\u5024\u3092\u4e0a\u6607\u3055\u305b\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u6cbb\u7642\u306a\u3069\u306b\u3088\u308b\u672b\u68a2\u8840\u6e05\u30ec\u30d9\u30eb\u306e\u4f4e\u4e0b\u304c\u3001\u81d3\u5668\u306b\u3088\u308b\u30b0\u30eb\u30b3\u30fc\u30b9\u306e\u5229\u7528\u3092\u52a9\u3051\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u5fc3\u6bd2\u6027\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u6291\u5236\u52b9\u679c\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u5897\u5f37\u306b\u4f9d\u5b58\u3057\u3066\u304a\u308a\u3001Dox \u306b\u3088\u308b\u5fc3\u81d3\u640d\u50b7\u306e\u72b6\u6cc1\u3067\u306f\u5fc3\u81d3\u4ee3\u8b1d\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3060\u3051\u3067\u306f\u84c4\u7a4d\u3057\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u9664\u53bb\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u8a98\u5c0e\u3059\u308b\u00a0<em>\u751f\u4f53\u5185<\/em>\u00a0PINK1\/\u30d1\u30fc\u30ad\u30f3\u7d4c\u8def\u3092\u901a\u3058\u3066\u5fc3\u7b4b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6052\u5e38\u6027\u3092\u56de\u5fa9\u3057\u3001\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u5fc3\u6bd2\u6027\u3092\u8efd\u6e1b\u3057\u307e\u3059\u3002\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u6d3b\u6027\u5316\u304c\u3055\u307e\u3056\u307e\u306a\u75be\u60a3\u306e\u767a\u751f\u3084\u767a\u75c7\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u8003\u616e\u3059\u308b\u3068\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u95a2\u9023\u75be\u60a3\u306e\u5019\u88dc\u85ac\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u81e8\u5e8a\u5fdc\u7528\u4fa1\u5024\u306f\u975e\u5e38\u306b\u9ad8\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u816b\u760d\u306e\u5897\u6b96\u3068\u816b\u760d\u7d30\u80de\u306e\u751f\u7269\u5b66\u7684\u6319\u52d5\u306b\u5bfe\u3057\u3066\u7279\u5b9a\u306e\u963b\u5bb3\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B55\" aria-expanded=\"false\" aria-haspopup=\"true\">Ye \u4ed6\u30012020<\/a>\uff09\u3002\u3053\u306e\u7814\u7a76\u306e\u7d50\u679c\u306f\u3001\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u304c\u4e73\u304c\u3093\u816b\u760d\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u8a98\u767a\u6027\u5fc3\u6a5f\u80fd\u4e0d\u5168\u3092\u4e88\u9632\u3057\u3001\u640d\u50b7\u3057\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u9664\u53bb\u3059\u308b\u3053\u3068\u3067\u708e\u75c7\u56e0\u5b50\u304a\u3088\u3073\u514d\u75ab\u6291\u5236\u6027\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u6d78\u6f64\u306e\u30ec\u30d9\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u306e\u6297\u816b\u760d\u52b9\u679c\u3068\u76f8\u4e57\u7684\u306a\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001\u30a2\u30f3\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u7cfb\u306e\u5fc3\u6bd2\u6027\u3092\u9632\u6b62\u3059\u308b\u3068\u3044\u3046\u3001\u304c\u3093\u306b\u5bfe\u3059\u308b\u4e8c\u91cd\u306e\u6cbb\u7642\u4e0a\u306e\u5229\u70b9\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u3067\u816b\u760d\u306e\u5897\u6b96\u3092\u6291\u5236\u3057\u307e\u3059\u3002\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306f\u3001\u30a2\u30f3\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u8a98\u767a\u6027\u5fc3\u6bd2\u6027\u304b\u3089\u4fdd\u8b77\u3057\u3001\u30a2\u30f3\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u306b\u5bfe\u3057\u3066\u76f8\u4e57\u7684\u306a\u6297\u816b\u760d\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u305f\u3081\u3001\u81e8\u5e8a\u5fdc\u7528\u306b\u512a\u308c\u305f\u4fa1\u5024\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"ack-a.m.a\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"ack-a.m.atitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u8b1d\u8f9e<\/h2>\n<div class=\"sec\">\n<p>\u8457\u8005\u3089\u306f\u3001\u8349\u6848\u306e\u4f5c\u6210\u3068\u30c7\u30fc\u30bf\u306e\u30ad\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306b\u3064\u3044\u3066\u3001\u4e2d\u56fd\u306e\u9752\u5cf6\u5927\u5b66\u4ed8\u5c5e\u75c5\u9662\u764c\u7814\u7a76\u6240\u3067\u3042\u308b W-SS \u306b\u611f\u8b1d\u3057\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<div id=\"s5\" class=\"tsec bk-sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"s5title\" class=\"head no_bottom_margin ui-helper-clearfix\">\u30c7\u30fc\u30bf\u5229\u7528\u53ef\u80fd\u6027\u306b\u95a2\u3059\u308b\u58f0\u660e<\/h2>\n<p class=\"p p-first-last\">\u7814\u7a76\u3067\u63d0\u793a\u3055\u308c\u305f\u30aa\u30ea\u30b8\u30ca\u30eb\u306e\u8ca2\u732e\u306f\u8a18\u4e8b\u306b\u542b\u307e\u308c\u3066\u3044\u307e\u3059\/<a class=\"sec\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#s11\">\u88dc\u8db3\u8cc7\u6599<\/a>;\u3055\u3089\u306b\u8a73\u3057\u3044\u554f\u3044\u5408\u308f\u305b\u306f\u8cac\u4efb\u8457\u8005\u306b\u554f\u3044\u5408\u308f\u305b\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"s6\" class=\"tsec bk-sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"s6title\" class=\"head no_bottom_margin ui-helper-clearfix\">\u502b\u7406\u58f0\u660e<\/h2>\n<p class=\"p p-first-last\">\u4eba\u9593\u306e\u53c2\u52a0\u8005\u3092\u542b\u3080\u7814\u7a76\u306f\u3001\u9752\u5cf6\u5927\u5b66\u4ed8\u5c5e\u75c5\u9662\u306e\u502b\u7406\u59d4\u54e1\u4f1a\u306b\u3088\u3063\u3066\u5be9\u67fb\u3055\u308c\u3001\u627f\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u60a3\u8005\/\u53c2\u52a0\u8005\u306f\u3001\u3053\u306e\u7814\u7a76\u306b\u53c2\u52a0\u3059\u308b\u305f\u3081\u306b\u66f8\u9762\u306b\u3088\u308b\u30a4\u30f3\u30d5\u30a9\u30fc\u30e0\u30c9\u30b3\u30f3\u30bb\u30f3\u30c8\u3092\u63d0\u4f9b\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u52d5\u7269\u5b9f\u9a13\u306f\u3001\u9752\u5cf6\u5927\u5b66\u533b\u79d1\u5927\u5b66\u306e\u502b\u7406\u59d4\u54e1\u4f1a\u306b\u3088\u3063\u3066\u5be9\u67fb\u3055\u308c\u3001\u627f\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"s7\" class=\"tsec bk-sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"s7title\" class=\"head no_bottom_margin ui-helper-clearfix\">\u8457\u8005\u306e\u5bc4\u7a3f<\/h2>\n<p class=\"p p-first-last\">M-JL \u3068 W-SS \u306f\u3059\u3079\u3066\u306e\u5b9f\u9a13\u3092\u5b9f\u65bd\u3057\u3001\u30c7\u30fc\u30bf\u3092\u5206\u6790\u3057\u3001\u539f\u6848\u3092\u4f5c\u6210\u3057\u307e\u3057\u305f\u3002 Y-KZ \u306f\u30c7\u30fc\u30bf\u3092\u5206\u6790\u3057\u3001\u539f\u6848\u3092\u4f5c\u6210\u3057\u307e\u3057\u305f\u3002 YY\u5206\u6790\u30c7\u30fc\u30bf\u3002 QL \u306f\u52d5\u7269\u306e\u30c7\u30fc\u30bf\u3092\u5206\u6790\u304a\u3088\u3073\u89e3\u91c8\u3057\u307e\u3057\u305f\u3002 Y-ZG\u306f\u52d5\u7269\u5b9f\u9a13\u3092\u884c\u3063\u305f\u3002 TY \u306f\u52d5\u7269\u5b9f\u9a13\u3092\u5b9f\u65bd\u3057\u307e\u3057\u305f\u3002 D-MX - \u539f\u7a3f\u3092\u30ec\u30d3\u30e5\u30fc\u3057\u3066\u7de8\u96c6\u3057\u307e\u3057\u305f\u3002\u8457\u8005\u5168\u54e1\u304c\u6700\u7d42\u539f\u7a3f\u3092\u8aad\u3093\u3067\u627f\u8a8d\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"s8\" class=\"tsec bk-sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"s8title\" class=\"head no_bottom_margin ui-helper-clearfix\">\u8cc7\u91d1\u8abf\u9054<\/h2>\n<p class=\"p p-first-last\">\u3053\u306e\u7814\u7a76\u306f\u3001\u9752\u5cf6\u304c\u3093\u7814\u7a76\u6240\u306e\u8cc7\u91d1\u63d0\u4f9b\u6a5f\u95a2\u304a\u3088\u3073\u9752\u5cf6\u535a\u58eb\u7814\u7a76\u54e1\u5fdc\u7528\u7814\u7a76\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\uff08\u756a\u53f7 RZ2100005362\uff09\u304b\u3089\u7279\u5b9a\u306e\u52a9\u6210\u91d1\u3092\u53d7\u3051\u307e\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"s9\" class=\"tsec bk-sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"s9title\" class=\"head no_bottom_margin ui-helper-clearfix\">\u5229\u76ca\u76f8\u53cd<\/h2>\n<p class=\"p p-first-last\">\u8457\u8005\u3089\u306f\u3001\u6f5c\u5728\u7684\u306a\u5229\u76ca\u76f8\u53cd\u3068\u307f\u306a\u3055\u308c\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u5546\u696d\u7684\u307e\u305f\u306f\u91d1\u92ad\u7684\u95a2\u4fc2\u304c\u5b58\u5728\u3057\u306a\u3044\u72b6\u614b\u3067\u7814\u7a76\u304c\u5b9f\u65bd\u3055\u308c\u305f\u3053\u3068\u3092\u5ba3\u8a00\u3057\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"s10\" class=\"tsec bk-sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"s10title\" class=\"head no_bottom_margin ui-helper-clearfix\">\u51fa\u7248\u793e\u306e\u30e1\u30e2<\/h2>\n<p class=\"p p-first-last\">\u3053\u306e\u8a18\u4e8b\u3067\u8868\u660e\u3055\u308c\u3066\u3044\u308b\u3059\u3079\u3066\u306e\u4e3b\u5f35\u306f\u5358\u306b\u8457\u8005\u306e\u4e3b\u5f35\u3067\u3042\u308a\u3001\u5fc5\u305a\u3057\u3082\u8457\u8005\u306e\u95a2\u9023\u7d44\u7e54\u3001\u307e\u305f\u306f\u51fa\u7248\u793e\u3001\u7de8\u96c6\u8005\u3001\u304a\u3088\u3073\u67fb\u8aad\u8005\u306e\u4e3b\u5f35\u3092\u4ee3\u8868\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3053\u306e\u8a18\u4e8b\u3067\u8a55\u4fa1\u3055\u308c\u3066\u3044\u308b\u88fd\u54c1\u3001\u307e\u305f\u306f\u305d\u306e\u88fd\u9020\u5143\u306b\u3088\u308b\u4e3b\u5f35\u306f\u3001\u767a\u884c\u8005\u306b\u3088\u3063\u3066\u4fdd\u8a3c\u307e\u305f\u306f\u627f\u8a8d\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"s11\" class=\"tsec bk-sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"s11title\" class=\"head no_bottom_margin ui-helper-clearfix\">\u88dc\u8db3\u8cc7\u6599<\/h2>\n<p class=\"p p-first\">\u3053\u306e\u8a18\u4e8b\u306e\u88dc\u8db3\u8cc7\u6599\u306f\u3001\u6b21\u306e\u5834\u6240\u3067\u30aa\u30f3\u30e9\u30a4\u30f3\u3067\u5165\u624b\u3067\u304d\u307e\u3059\u3002\u00a0<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.930835\/full#supplementary-material\" target=\"_blank\" rel=\"noopener\" data-ga-action=\"click_feat_suppl\">https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.930835\/full#supplementary-material<\/a><\/p>\n<div id=\"SM1\" class=\"sec suppmat\">\n<div id=\"media-a.m.h.c.a\" class=\"sup-box half_rhythm\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/bin\/Table1.DOCX\" data-ga-action=\"click_feat_suppl\">\u8ffd\u52a0\u306e\u30c7\u30fc\u30bf\u30d5\u30a1\u30a4\u30eb\u306b\u3064\u3044\u3066\u306f\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/a><sup>(2.5M\u3001DOCX)<\/sup><\/div>\n<div><\/div>\n<\/div>\n<\/div>\n<div id=\"ref-list-a.m.i\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u3053\u306e\u30da\u30fc\u30b8\u306e\u4ed6\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u306b\u79fb\u52d5\u3059\u308b\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n<h2 id=\"ref-list-a.m.ititle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u53c2\u8003\u6587\u732e<\/h2>\n<p>&nbsp;<\/p>\n<div id=\"reference-list\" class=\"ref-list-sec sec\">\n<ul class=\"back-ref-list\">\n<li id=\"B1\"><span class=\"mixed-citation\">Alexandre J.\u3001Cautela J.\u3001Ederhy S.\u3001Damaj GL\u3001Salem JE\u3001Barlesi F.\u3001\u4ed6\u3002 \uff082020\u5e74\uff09\u3002\u00a0<span class=\"ref-title\">\u304c\u3093\u6cbb\u7642\u306b\u95a2\u9023\u3057\u305f\u5fc3\u8840\u7ba1\u6bd2\u6027\uff1a\u7c73\u56fd\u304a\u3088\u3073\u6b27\u5dde\u306e\u5fc3\u81d3\u816b\u760d\u5b66\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3078\u306e\u5b9f\u7528\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1<\/span>.\u00a0<span class=\"ref-journal\">\u6df7\u96d1\u3059\u308b\u3002\u5fc3\u81d3\u5354\u4f1a<\/span>\u00a0<span class=\"ref-vol\">9<\/span>\u00a0(<span class=\"ref-iss\">18<\/span>)\u3001e018403\u3002 10.1161\/JAHA.120.018403\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7727003\/\">PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32893704\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1161%2FJAHA.120.018403\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" 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(2021)\u3002\u00a0<span class=\"ref-title\">\u7cd6\u5c3f\u75c5\u6027\u5fc3\u81d3\u306b\u304a\u3051\u308b\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\uff1a\u7cd6\u5c3f\u75c5\u6027\u5fc3\u7b4b\u75c7\u306b\u304a\u3051\u308b\u6f5c\u5728\u7684\u306a\u85ac\u7269\u7642\u6cd5\u6a19\u7684<\/span>.\u00a0<span class=\"ref-journal\">\u7d4c\u5e74\u52a3\u5316\u8010\u6027\u7267\u5e2b<\/span>\u00a0<span class=\"ref-vol\">68<\/span>\u3001101338\u300210.1016\/j.arr.2021.101338 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33838320\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1016%2Fj.arr.2021.101338\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" 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class=\"ref-vol\">95<\/span>\u300142\u201349\u3002 10.1016\/j.yjmcc.2015.11.023\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4876055\/\">PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26611886\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1016%2Fj.yjmcc.2015.11.023\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.+Mol.+Cell.+Cardiol.&amp;title=Parkin-dependent+mitophagy+in+the+heart&amp;author=G.+W.+Dorn&amp;volume=95&amp;publication_year=2016&amp;pages=42-49&amp;pmid=26611886&amp;doi=10.1016\/j.yjmcc.2015.11.023&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B9\"><span class=\"mixed-citation\">Elinav E.\u3001Nowarski R.\u3001Thaiss CA\u3001Hu B.\u3001Jin C.\u3001Flavell RA (2013)\u3002\u00a0<span class=\"ref-title\">\u708e\u75c7\u8a98\u767a\u6027\u304c\u3093: \u816b\u760d\u3001\u514d\u75ab\u7d30\u80de\u3001\u5fae\u751f\u7269\u9593\u306e\u30af\u30ed\u30b9\u30c8\u30fc\u30af<\/span>.\u00a0<span class=\"ref-journal\">\u30ca\u30c3\u30c8\u3002\u304c\u3093\u7267\u5e2b<\/span>\u00a0<span class=\"ref-vol\">13<\/span>\u00a0(<span class=\"ref-iss\">11<\/span>\uff09\u3001759\u2013771\u3002 10.1038\/nrc3611 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24154716\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1038%2Fnrc3611\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" 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class=\"ref-vol\">8<\/span>\u3001289.10.3389\/fphar.2017.00289\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/\">PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28588491\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.3389%2Ffphar.2017.00289\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Front.+Pharmacol.&amp;title=Therapeutic+effects+of+breviscapine+in+cardiovascular+diseases:+A+review&amp;author=J.+Gao&amp;author=G.+Chen&amp;author=H.+He&amp;author=C.+Liu&amp;author=X.+Xiong&amp;volume=8&amp;publication_year=2017&amp;pages=289&amp;pmid=28588491&amp;doi=10.3389\/fphar.2017.00289&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B11\"><span class=\"mixed-citation\">\u30b0\u30ec\u30fc MW (2012)\u3002\u00a0<span class=\"ref-title\">\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u9032\u5316<\/span>.\u00a0<span class=\"ref-journal\">\u30b3\u30fc\u30eb\u30c9\u30b9\u30d7\u30ea\u30f3\u30b0\u30cf\u30fc\u30d6\u3002\u8996\u70b9\u3002\u30d0\u30a4\u30aa\u30eb\u3002<\/span>\u00a0<span class=\"ref-vol\">4<\/span>\u00a0(<span class=\"ref-iss\">9<\/span>\uff09\u3001a011403\u3002 10.1101\/cshperspect.a011403\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3428767\/\">PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22952398\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1101%2Fcshperspect.a011403\" target=\"_blank\" rel=\"noopener 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(2018)\u3002\u00a0<span class=\"ref-title\">\u5fc3\u4e0d\u5168\u306b\u304a\u3051\u308b\u9006\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3068\u5fc3\u7b4b\u56de\u5fa9<\/span>.\u00a0<span class=\"ref-journal\">\u30ca\u30c3\u30c8\u3002\u30ab\u30fc\u30c7\u30a3\u30aa\u30fc\u30eb\u7267\u5e2b\u3002<\/span>\u00a0<span class=\"ref-vol\">15<\/span>\u00a0(<span class=\"ref-iss\">2<\/span>\uff09\u300183\u201396\u3002 10.1038\/nrcardio.2017.139 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28933783\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1038%2Fnrcardio.2017.139\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Nat.+Rev.+Cardiol.&amp;title=Reverse+remodelling+and+myocardial+recovery+in+heart+failure&amp;author=G.+H.+Kim&amp;author=N.+Uriel&amp;author=D.+Burkhoff&amp;volume=15&amp;issue=2&amp;publication_year=2018&amp;pages=83-96&amp;pmid=28933783&amp;doi=10.1038\/nrcardio.2017.139&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B17\"><span class=\"mixed-citation\">\u5317\u65b9 \u6d0b\u3001\u9060\u85e4 \u7d14\u3001\u4f0a\u5009 \u79c0\u3001\u68ee\u5c71 \u6d0b\u3001\u767d\u5ddd \u548c\u4e5f\u3001\u52dd\u4fe3 \u88d5\u4e5f\u3001\u4ed6\uff082022\u5e74\uff09\u3002\u00a0<span class=\"ref-title\">DOX \u8a98\u767a\u6027\u5fc3\u7b4b\u75c7\u306e\u6cbb\u7642\u6a19\u7684: \u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3068\u30d5\u30a7\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u5f79\u5272<\/span>.\u00a0<span class=\"ref-journal\">\u5185\u90e8\u3002 \uff2a\uff0e\uff2d\uff4f\uff4c\uff0e\u79d1\u5b66\u3002<\/span>\u00a0<span class=\"ref-vol\">23<\/span>\u00a0(<span class=\"ref-iss\">3<\/span>)\u30011414.10.3390\/ijms23031414\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8835899\/\">PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35163335\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.3390%2Fijms23031414\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Int.+J.+Mol.+Sci.&amp;title=Therapeutic+targets+for+DOX-induced+cardiomyopathy:+Role+of+apoptosis+vs.+Ferroptosis&amp;author=H.+Kitakata&amp;author=J.+Endo&amp;author=H.+Ikura&amp;author=H.+Moriyama&amp;author=K.+Shirakawa&amp;volume=23&amp;issue=3&amp;publication_year=2022&amp;pages=1414&amp;pmid=35163335&amp;doi=10.3390\/ijms23031414&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B18\"><span class=\"mixed-citation\">\u30b3\u30eb\u30a6\u30a3\u30c3\u30c4 SC\u3001\u30b8\u30e5\u30cb\u30a2\u3001\u30d7\u30ed\u30d2\u30c3\u30c8 S.\u3001\u30c6\u30a3\u30a2\u30f3 R. 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(2011)\u3002\u00a0<span class=\"ref-title\">\u7cd6\u4ee3\u8b1d\u3068\u5fc3\u80a5\u5927<\/span>.\u00a0<span class=\"ref-journal\">\u5fc3\u81d3\u8840\u7ba1\u3002\u89e3\u50cf\u5ea6<\/span>\u00a0<span class=\"ref-vol\">90<\/span>\u00a0(<span class=\"ref-iss\">2<\/span>\uff09\u3001194\u2013201\u3002 10.1093\/cvr\/cvr071\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3078804\/\">PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21502371\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1093%2Fcvr%2Fcvr071\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" 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class=\"ref-journal\">\u30e9\u30f3\u30bb\u30c3\u30c8\u3002\u30aa\u30f3\u30b3\u30eb\u3002<\/span>\u00a0<span class=\"ref-vol\">18<\/span>\u00a0(<span class=\"ref-iss\">8<\/span>)\u3001e445\u2013e456\u3002 10.1016\/S1470-2045(17)30535-1 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28759384\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1016%2FS1470-2045(17)30535-1\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Lancet.+Oncol.&amp;title=Cardiotoxic+effects+of+anthracycline-based+therapy:+What+is+the+evidence+and+what+are+the+potential+harms?&amp;author=B.+E.+Levis&amp;author=P.+F.+Binkley&amp;author=C.+L.+Shapiro&amp;volume=18&amp;issue=8&amp;publication_year=2017&amp;pages=e445-e456&amp;pmid=28759384&amp;doi=10.1016\/S1470-2045(17)30535-1&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B21\"><span class=\"mixed-citation\">Li M.\u3001Sala V.\u3001De Santis MC\u3001Cimino J.\u3001Cappello P.\u3001Pianca N.\u3001\u4ed6\uff082018\u5e74\uff09\u3002\u00a0<span class=\"ref-title\">\u30db\u30b9\u30db\u30a4\u30ce\u30b7\u30c1\u30c9 3-\u30ad\u30ca\u30fc\u30bc \u30ac\u30f3\u30de\u963b\u5bb3\u306b\u3088\u308a\u3001\u30a2\u30f3\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u7cfb\u5fc3\u6bd2\u6027\u304b\u3089\u4fdd\u8b77\u3057\u3001\u816b\u760d\u5897\u6b96\u3092\u6291\u5236\u3057\u307e\u3059<\/span>.\u00a0<span class=\"ref-journal\">\u5faa\u74b0<\/span>\u00a0<span class=\"ref-vol\">138<\/span>\u00a0(<span class=\"ref-iss\">7<\/span>\uff09\u3001696\u2013711\u3002 10.1161\/\u5faa\u74b0AHA.117.030352 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29348263\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1161%2FCIRCULATIONAHA.117.030352\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Circulation&amp;title=Phosphoinositide+3-kinase+gamma+inhibition+protects+from+anthracycline+cardiotoxicity+and+reduces+tumor+growth&amp;author=M.+Li&amp;author=V.+Sala&amp;author=M.+C.+De+Santis&amp;author=J.+Cimino&amp;author=P.+Cappello&amp;volume=138&amp;issue=7&amp;publication_year=2018&amp;pages=696-711&amp;pmid=29348263&amp;doi=10.1161\/CIRCULATIONAHA.117.030352&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B22\"><span class=\"mixed-citation\">Li M.\u3001Yuan Y.\u3001Sun W.\u3001Zhang Y.\u3001Lu Q.\u3001Zou L.\u3001\u4ed6\u3002 \uff082022\u5e74\uff09\u3002\u00a0<span class=\"ref-title\">\u30e1\u30bf\u30dc\u30ed\u30df\u30af\u30b9\u306b\u57fa\u3065\u304f\u30c9\u30ad\u30bd \u30eb\u30d3\u30b7\u30f3\u8a98\u767a\u6027\u5fc3\u6bd2\u6027\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u306e\u30e1\u30ab\u30cb\u30ba\u30e0<\/span>.\u00a0<span class=\"ref-journal\">\u984e\u3002\u30cf\u30fc\u30d6\u3002\u533b\u5b66\u3002<\/span>\u00a0<span class=\"ref-vol\">53<\/span>\u00a0(<span class=\"ref-iss\">08<\/span>\uff09\u30012356\u20132367\u3002 10.7501\/j.issn.0253-2670.2022.08.0 [<a href=\"https:\/\/doi.org\/10.7501%2Fj.issn.0253-2670.2022.08.0\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Chin.+Herb.+Med.&amp;title=Mechanisms+of+breviscapine+against+doxo+rubicin-induced+cardiotoxicity+based+on+metabolomics&amp;author=M.+Li&amp;author=Y.+Yuan&amp;author=W.+Sun&amp;author=Y.+Zhang&amp;author=Q.+Lu&amp;volume=53&amp;issue=08&amp;publication_year=2022&amp;pages=2356-2367&amp;doi=10.7501\/j.issn.0253-2670.2022.08.0&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B23\"><span class=\"mixed-citation\">Li Z.\u3001Zhang H. (2016)\u3002\u00a0<span class=\"ref-title\">\u764c\u9032\u884c\u306e\u305f\u3081\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u3001\u8102\u80aa\u9178\u3001\u30a2\u30df\u30ce\u9178\u4ee3\u8b1d\u306e\u518d\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0<\/span>.\u00a0<span class=\"ref-journal\">\u7d30\u80de\u3002\u30e2\u30eb\u3002\u751f\u547d\u79d1\u5b66\u3002<\/span>\u00a0<span class=\"ref-vol\">73<\/span>\u00a0(<span class=\"ref-iss\">2<\/span>\uff09\u3001377\u2013392\u3002 10.1007\/s00018-015-2070-4 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26499846\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1007%2Fs00018-015-2070-4\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Cell.+Mol.+Life+Sci.&amp;title=Reprogramming+of+glucose,+fatty+acid+and+amino+acid+metabolism+for+cancer+progression&amp;author=Z.+Li&amp;author=H.+Zhang&amp;volume=73&amp;issue=2&amp;publication_year=2016&amp;pages=377-392&amp;pmid=26499846&amp;doi=10.1007\/s00018-015-2070-4&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B24\"><span class=\"mixed-citation\">Liu H.\u3001Wang H.\u3001Xiang D.\u3001Guo W. (2017)\u3002\u00a0<span class=\"ref-title\">\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u8a98\u767a\u6027\u5fc3\u6bd2\u6027\u3092\u4e88\u9632\u3059\u308b\u305f\u3081\u306e\u85ac\u5b66\u7684\u5bfe\u7b56<\/span>.\u00a0<span class=\"ref-journal\">\u30df\u30cb\u7267\u5e2b\u533b\u5b66\u3002\u5316\u5b66\u3002<\/span>\u00a0<span class=\"ref-vol\">17<\/span>\u00a0(<span class=\"ref-iss\">1<\/span>\uff09\u300144\u201350\u3002 10.2174\/1389557516666160621083659 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27337969\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.2174%2F1389557516666160621083659\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" 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class=\"ref-journal\">\u751f\u7406\u3002\u7267\u5e2b<\/span>\u00a0<span class=\"ref-vol\">90<\/span>\u00a0(<span class=\"ref-iss\">1<\/span>\uff09\u3001207\u2013258\u3002 10.1152\/physrev.00015.2009 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20086077\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1152%2Fphysrev.00015.2009\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Physiol.+Rev.&amp;title=Myocardial+fatty+acid+metabolism+in+health+and+disease&amp;author=G.+D.+Lopaschuk&amp;author=J.+R.+Ussher&amp;author=C.+D.+Folmes&amp;author=J.+S.+Jaswal&amp;author=W.+C.+Stanley&amp;volume=90&amp;issue=1&amp;publication_year=2010&amp;pages=207-258&amp;pmid=20086077&amp;doi=10.1152\/physrev.00015.2009&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B26\"><span class=\"mixed-citation\">\u30ed\u30d1\u30b7\u30e5\u30af GD\u3001\u30ab\u30eb\u30a6\u30a3 QG\u3001\u30c6\u30a3\u30a2\u30f3 R.\u3001\u30a6\u30a7\u30f3\u30c7 AR\u3001\u30a2\u30d9\u30eb ED (2021)\u3002\u00a0<span class=\"ref-title\">\u5fc3\u4e0d\u5168\u306b\u304a\u3051\u308b\u5fc3\u81d3\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d<\/span>.\u00a0<span class=\"ref-journal\">\u5186\u89e3\u50cf\u5ea6<\/span>\u00a0<span class=\"ref-vol\">128<\/span>\u00a0(<span class=\"ref-iss\">10<\/span>\uff09\u30011487\u20131513\u3002 10.1161\/CIRCRESAHA.121.318241\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8136750\/\">PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33983836\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1161%2FCIRCRESAHA.121.318241\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Circ.+Res.&amp;title=Cardiac+energy+metabolism+in+heart+failure&amp;author=G.+D.+Lopaschuk&amp;author=Q.+G.+Karwi&amp;author=R.+Tian&amp;author=A.+R.+Wende&amp;author=E.+D.+Abel&amp;volume=128&amp;issue=10&amp;publication_year=2021&amp;pages=1487-1513&amp;pmid=33983836&amp;doi=10.1161\/CIRCRESAHA.121.318241&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B27\"><span class=\"mixed-citation\">McGowan JV\u3001Chung R.\u3001Maulik A.\u3001Piotrowska I.\u3001Walker JM\u3001Yellon DM (2017)\u3002\u00a0<span class=\"ref-title\">\u30a2\u30f3\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u7cfb\u5316\u5b66\u7642\u6cd5\u3068\u5fc3\u6bd2\u6027<\/span>.\u00a0<span class=\"ref-journal\">\u5fc3\u81d3\u8840\u7ba1\u3002\u30c9\u30e9\u30c3\u30b0\u30b5\u30fc\u3002<\/span>\u00a0<span class=\"ref-vol\">31<\/span>\u00a0(<span class=\"ref-iss\">1<\/span>\uff09\u300163\u201375\u3002 10.1007\/s10557-016-6711-0\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5346598\/\">PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28185035\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1007%2Fs10557-016-6711-0\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" 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class=\"ref-iss\">3<\/span>\uff09\u3001193\u2013207\u3002 10.1016\/j.it.2016.01.002\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4916957\/\">PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26839260\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1016%2Fj.it.2016.01.002\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Trends+Immunol.&amp;title=Ido+in+the+tumor+microenvironment:+Inflammation,+counter-regulation,+and+tolerance&amp;author=D.+H.+Munn&amp;author=A.+L.+Mellor&amp;volume=37&amp;issue=3&amp;publication_year=2016&amp;pages=193-207&amp;pmid=26839260&amp;doi=10.1016\/j.it.2016.01.002&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B29\"><span class=\"mixed-citation\">\u6751\u91cdD.\u3001Jang C.\u3001Neinast M.\u3001Edwards JJ\u3001Cowan A.\u3001Hyman MC\u3001\u4ed6\u3002 \uff082020\u5e74\uff09\u3002\u00a0<span class=\"ref-title\">\u4eba\u9593\u306e\u5fc3\u81d3\u306e\u6545\u969c\u3068\u975e\u6545\u969c\u306b\u3088\u308b\u71c3\u6599\u4f7f\u7528\u91cf\u306e\u5305\u62ec\u7684\u306a\u5b9a\u91cf\u5316<\/span>.\u00a0<span class=\"ref-journal\">\u79d1\u5b66<\/span>\u00a0<span class=\"ref-vol\">370<\/span>\u00a0(<span class=\"ref-iss\">6514<\/span>\uff09\u3001364\u2013368\u3002 10.1126\/science.abc8861\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7871704\/\">PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33060364\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1126%2Fscience.abc8861\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Science&amp;title=Comprehensive+quantification+of+fuel+use+by+the+failing+and+nonfailing+human+heart&amp;author=D.+Murashige&amp;author=C.+Jang&amp;author=M.+Neinast&amp;author=J.+J.+Edwards&amp;author=A.+Cowan&amp;volume=370&amp;issue=6514&amp;publication_year=2020&amp;pages=364-368&amp;pmid=33060364&amp;doi=10.1126\/science.abc8861&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B30\"><span class=\"mixed-citation\">Nhu NT\u3001Li Q.\u3001Liu Y.\u3001Xu J.\u3001Xiao SY\u3001Lee SD (2021)\u3002\u00a0<span class=\"ref-title\">\u8133\u5352\u4e2d\u5f8c\u306e\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u306b\u304a\u3051\u308b\u795e\u7d4c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u4e0d\u5168\u304a\u3088\u3073\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5a92\u4ecb\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306b\u5bfe\u3059\u308b mdivi-1 \u306e\u52b9\u679c: \u524d\u81e8\u5e8a\u7814\u7a76\u306e\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc<\/span>.\u00a0<span class=\"ref-journal\">\u30d5\u30ed\u30f3\u30c8\u3002\u30e2\u30eb\u3002\u795e\u7d4c\u79d1\u5b66\u3002<\/span>\u00a0<span class=\"ref-vol\">14<\/span>\u3001778569\u300210.3389\/fnmol.2021.778569\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8740201\/\">PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35002619\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.3389%2Ffnmol.2021.778569\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Front.+Mol.+Neurosci.&amp;title=Effects+of+mdivi-1+on+neural+mitochondrial+dysfunction+and+mitochondria-mediated+apoptosis+in+ischemia-reperfusion+injury+after+stroke:+A+systematic+review+of+preclinical+studies&amp;author=N.+T.+Nhu&amp;author=Q.+Li&amp;author=Y.+Liu&amp;author=J.+Xu&amp;author=S.+Y.+Xiao&amp;volume=14&amp;publication_year=2021&amp;pages=778569&amp;pmid=35002619&amp;doi=10.3389\/fnmol.2021.778569&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B31\"><span class=\"mixed-citation\">\u30aa\u30ab\u30c6\u30a3 BW\u3001\u30b3\u30e2\u30f3\u30ba KG\u3001\u30c7\u30a3\u30e1\u30c3\u30ad SM (2019)\u3002\u00a0<span class=\"ref-title\">5-HT \u795e\u7d4c\u7cfb\u306b\u304a\u3051\u308b\u591a\u69d8\u6027\u306e\u53d7\u3051\u5165\u308c<\/span>.\u00a0<span class=\"ref-journal\">\u30ca\u30c3\u30c8\u3002\u795e\u7d4c\u79d1\u5b66\u7267\u5e2b\u3002<\/span>\u00a0<span class=\"ref-vol\">20<\/span>\u00a0(<span class=\"ref-iss\">7<\/span>\uff09\u3001397\u2013424\u3002 10.1038\/s41583-019-0151-3 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30948838\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1038%2Fs41583-019-0151-3\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Nat.+Rev.+Neurosci.&amp;title=Embracing+diversity+in+the+5-HT+neuronal+system&amp;author=B.+W.+Okaty&amp;author=K.+G.+Commons&amp;author=S.+M.+Dymecki&amp;volume=20&amp;issue=7&amp;publication_year=2019&amp;pages=397-424&amp;pmid=30948838&amp;doi=10.1038\/s41583-019-0151-3&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B32\"><span class=\"mixed-citation\">Pan Y.\u3001Yu Y.\u3001Wang X.\u3001Zhang T. (2020)\u3002\u00a0<span class=\"ref-title\">\u816b\u760d\u514d\u75ab\u306b\u304a\u3051\u308b\u816b\u760d\u95a2\u9023\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8<\/span>.\u00a0<span class=\"ref-journal\">\u30d5\u30ed\u30f3\u30c8\u3002\u30a4\u30e0\u30ce\u30fc\u30eb\u3002<\/span>\u00a0<span class=\"ref-vol\">11<\/span>\u3001583084\u300210.3389\/fimmu.2020.583084\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7751482\/\">PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33365025\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.3389%2Ffimmu.2020.583084\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" 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10.1007\/s00018-021-03774-1\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8259496\/\">PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33580835\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1007%2Fs00018-021-03774-1\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Cell.+Mol.+Life+Sci.&amp;title=Mitophagy+in+tumorigenesis+and+metastasis&amp;author=L.+P.+Poole&amp;author=K.+F.+Macleod&amp;volume=78&amp;issue=8&amp;publication_year=2021&amp;pages=3817-3851&amp;pmid=33580835&amp;doi=10.1007\/s00018-021-03774-1&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B34\"><span class=\"mixed-citation\">\u30e9\u30f3\u30c9\u30eb PJ\u3001\u30ac\u30fc\u30e9\u30f3\u30c9 PB\u3001\u30d8\u30a4\u30eb\u30ba CN\u3001\u30cb\u30e5\u30fc\u30b9\u30db\u30eb\u30e0 EA (1963)\u3002\u00a0<span class=\"ref-title\">\u30b0\u30eb\u30b3\u30fc\u30b9\u8102\u80aa\u9178\u56de\u8def\u3002\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3068\u7cd6\u5c3f\u75c5\u306e\u4ee3\u8b1d\u969c\u5bb3\u306b\u304a\u3051\u308b\u305d\u306e\u5f79\u5272<\/span>.\u00a0<span class=\"ref-journal\">\u30e9\u30f3\u30bb\u30c3\u30c8<\/span>\u00a0<span class=\"ref-vol\">1<\/span>\u00a0(<span class=\"ref-iss\">7285<\/span>\uff09\u3001785\u2013789\u3002 10.1016\/s0140-6736(63)91500-9 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/13990765\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1016%2Fs0140-6736(63)91500-9\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" 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class=\"ref-title\">\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\u8a98\u767a\u5fc3\u6bd2\u6027\u306b\u5bfe\u3059\u308b\u30d4\u30ce\u30bb\u30f3\u30d6\u30ea\u30f3\u306e\u4e88\u9632\u52b9\u679c\u00a0<em>\u8a66\u9a13\u7ba1\u5185\u3067<\/em>\u00a0H9c2\u7d30\u80de\u30e2\u30c7\u30eb<\/span>.\u00a0<span class=\"ref-journal\">\u30d5\u30ed\u30f3\u30c8\u3002\u85ac\u7406\u5b66\u3002<\/span>\u00a0<span class=\"ref-vol\">11<\/span>\u30011172\u300210.3389\/fphar.2020.01172\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7438920\/\">PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32903793\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.3389%2Ffphar.2020.01172\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" 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class=\"ref-journal\">\u30ca\u30c3\u30c8\u3002\u304c\u3093\u7267\u5e2b<\/span>\u00a0<span class=\"ref-vol\">19<\/span>\u00a0(<span class=\"ref-iss\">6<\/span>\uff09\u3001307\u2013325\u3002 10.1038\/s41568-019-0144-6 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31092904\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1038%2Fs41568-019-0144-6\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Nat.+Rev.+Cancer&amp;title=Tertiary+lymphoid+structures+in+the+era+of+cancer+immunotherapy&amp;author=C.+Sautes-Fridman&amp;author=F.+Petitprez&amp;author=J.+Calderaro&amp;author=W.+H.+Fridman&amp;volume=19&amp;issue=6&amp;publication_year=2019&amp;pages=307-325&amp;pmid=31092904&amp;doi=10.1038\/s41568-019-0144-6&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B37\"><span class=\"mixed-citation\">Sawicki KT\u3001Sala V.\u3001Prever L.\u3001Hirsch E.\u3001Ardehali H.\u3001Ghigo A. 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href=\"https:\/\/doi.org\/10.3389%2Ffimmu.2017.00508\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Front.+Immunol.&amp;title=Mitochondria-derived+damage-associated+molecular+patterns+in+neurodegeneration&amp;author=H.+M.+Wilkins&amp;author=I.+W.+Weidling&amp;author=Y.+Ji&amp;author=R.+H.+Swerdlow&amp;volume=8&amp;publication_year=2017&amp;pages=508&amp;pmid=28491064&amp;doi=10.3389\/fimmu.2017.00508&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B50\"><span class=\"mixed-citation\">Wu L.\u3001Gao Y.\u3001Zhang S.\u3001Fang Z. (2019)\u3002\u00a0<span class=\"ref-title\">\u9ad8\u8840\u5727\u8a98\u767a\u6027\u814e\u969c\u5bb3\u60a3\u8005\u306e\u9ad8\u8840\u5727\u306b\u5bfe\u3059\u308b\u30d6\u30ec\u30d3\u30b9\u30ab\u30d4\u30f3\u6ce8\u5c04\u306e\u52b9\u679c\uff1a\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\u3068\u30e1\u30bf\u5206\u6790<\/span>.\u00a0<span class=\"ref-journal\">\u30d5\u30ed\u30f3\u30c8\u3002\u85ac\u7406\u5b66\u3002<\/span>\u00a0<span class=\"ref-vol\">10<\/span>\u3001118.10.3389\/fphar.2019.00118\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6394135\/\">PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30846938\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.3389%2Ffphar.2019.00118\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" 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class=\"ref-journal\">\u30e2\u30eb\u3002\u7cbe\u795e\u79d1<\/span>\u00a0<span class=\"ref-vol\">26<\/span>\u00a0(<span class=\"ref-iss\">7<\/span>\uff09\u30012837\u20132853\u3002 10.1038\/s41380-021-01053-w\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8505263\/\">PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33767348\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1038%2Fs41380-021-01053-w\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Mol.+Psychiatry&amp;title=Reciprocal+control+of+obesity+and+anxiety-depressive+disorder+via+a+GABA+and+serotonin+neural+circuit&amp;author=G.+Xia&amp;author=Y.+Han&amp;author=F.+Meng&amp;author=Y.+He&amp;author=D.+Srisai&amp;volume=26&amp;issue=7&amp;publication_year=2021&amp;pages=2837-2853&amp;pmid=33767348&amp;doi=10.1038\/s41380-021-01053-w&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<li id=\"B52\"><span class=\"mixed-citation\">Xie S.\u3001Sun W.\u3001Zhang C.\u3001Dong B.\u3001Yang J.\u3001Hou M.\u3001\u4ed6\u3002 \uff082021\u5e74\uff09\u3002\u00a0<span class=\"ref-title\">\u52b9\u679c\u7684\u306a\u304c\u3093\u6cbb\u7642\u306e\u305f\u3081\u306e\u30d5\u30a7\u30ed\u30c8\u30fc\u30b7\u30b9\u3078\u306e\u7d30\u80de\u904b\u547d\u3092\u6c7a\u5b9a\u3059\u308b\u71b1\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u4ee3\u8b1d\u5236\u5fa1<\/span>.\u00a0<span class=\"ref-journal\">ACS\u30ca\u30ce<\/span>\u00a0<span class=\"ref-vol\">15<\/span>\u00a0(<span class=\"ref-iss\">4<\/span>\uff09\u30017179\u20137194\u3002 10.1021\/acsnano.1c00380 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33861924\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1021%2Facsnano.1c00380\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" 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class=\"ref-iss\">2<\/span>)\u3001996.10.3390\/ijms23020996\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8779056\/\">PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35055179\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.3390%2Fijms23020996\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Int.+J.+Mol.+Sci.&amp;title=Deranged+myocardial+fatty+acid+metabolism+in+heart+failure&amp;author=T.+Yamamoto&amp;author=M.+Sano&amp;volume=23&amp;issue=2&amp;publication_year=2022&amp;pages=996&amp;pmid=35055179&amp;doi=10.3390\/ijms23020996&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google 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class=\"ref-title\">\u5fc3\u81d3PI3K-Akt\u306f\u3001mTORC1\u304a\u3088\u3073GLUT4\u8ee2\u5ea7\u3068\u306f\u7121\u95a2\u4fc2\u306b\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u523a\u6fc0\u306b\u3088\u308b\u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u3092\u963b\u5bb3\u3059\u308b<\/span>.\u00a0<span class=\"ref-journal\">\u30e2\u30eb\u3002\u5185\u5206\u6ccc\u3002<\/span>\u00a0<span class=\"ref-vol\">27<\/span>\u00a0(<span class=\"ref-iss\">1<\/span>\uff09\u3001172\u2013184\u3002 10.1210\/me.2012-1210\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3545208\/\">PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23204326\">\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>] [<a href=\"https:\/\/doi.org\/10.1210%2Fme.2012-1210\" target=\"_blank\" rel=\"noopener noreferrer\">\u30af\u30ed\u30b9\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Mol.+Endocrinol.&amp;title=Cardiac+PI3K-Akt+impairs+insulin-stimulated+glucose+uptake+independent+of+mTORC1+and+GLUT4+translocation&amp;author=Y.+Zhu&amp;author=R.+O.+Pereira&amp;author=B.+T.+O%27Neill&amp;author=C.+Riehle&amp;author=O.+Ilkun&amp;volume=27&amp;issue=1&amp;publication_year=2013&amp;pages=172-184&amp;pmid=23204326&amp;doi=10.1210\/me.2012-1210&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#:~:text=Interestingly%2C%20breviscapine%20increases%20the%20efficiency,heart%20and%20reducing%20lipid%20oxidation\">\u30bd\u30fc\u30b9<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u5e83\u57df\u6297\u304c\u3093\u5264\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3 (Dox) 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