{"id":5191,"date":"2024-01-16T11:44:11","date_gmt":"2024-01-16T11:44:11","guid":{"rendered":"https:\/\/farlong.com\/?p=5191"},"modified":"2024-01-27T10:08:04","modified_gmt":"2024-01-27T10:08:04","slug":"optimization-of-quercitrin-and-total-flavonoids-extraction-from-herba-polygoni-capitati-by-response-surface-methodology-2","status":"publish","type":"post","link":"https:\/\/directcm.com\/ja\/optimization-of-quercitrin-and-total-flavonoids-extraction-from-herba-polygoni-capitati-by-response-surface-methodology-2\/","title":{"rendered":"\u5fdc\u7b54\u66f2\u9762\u6cd5\u306b\u3088\u308b Herba Polygoni Capitati \u304b\u3089\u306e\u30b1\u30eb\u30b7\u30c8\u30ea\u30f3\u3068\u7dcf\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u62bd\u51fa\u306e\u6700\u9069\u5316"},"content":{"rendered":"
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\u30d5\u30a1\u30fc\u30de\u30b3\u30fc\u30b0\u8a8c\u3002<\/a><\/span>\u00a02014\u5e741\u6708-2\u6708; 10(Suppl 1): S57\u2013S64.<\/div>\n
\u571f\u4e95:\u00a010.4103\/0973-1296.127343<\/a><\/span><\/div>\n<\/div>\n<\/div>\n
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\u500b\u4ebaID:\u00a0<\/span>\uff30\uff2d\uff23\uff14\uff10\uff14\uff17\uff15\uff18\uff12<\/div>\n
PMID:\u00a024914309<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/figure>\n<\/div>\n<\/div>\n
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\u5ba2\u89b3\u7684\uff1a<\/h3>\n

\u5fdc\u7b54\u66f2\u9762\u6cd5 (RSM) \u3092\u4f7f\u7528\u3057\u3066\u3001Herba Polygoni Capitati (\u4e2d\u56fd\u8a9e\u3067\u306f\u8c46\u82b1\u5bee) \u304b\u3089\u306e\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3068\u7dcf\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9 (TF) \u306e\u62bd\u51fa\u6761\u4ef6\u3092\u6700\u9069\u5316\u3057\u307e\u3059\u3002<\/p>\n<\/div>\n

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\u6750\u6599\u3068\u65b9\u6cd5\uff1a<\/h3>\n

\u4e2d\u5fc3\u8907\u5408\u8a2d\u8a08 (CCD) \u3092\u63a1\u7528\u3057\u3066\u3001\u6eb6\u5a92\u7d44\u6210 (%)\u3001\u6eb6\u5a92\u3068\u6750\u6599\u306e\u6bd4\u7387 (ml\/g)\u3001\u62bd\u51fa\u6642\u9593 (\u5206) \u3092\u542b\u3080 3 \u3064\u306e\u72ec\u7acb\u5909\u6570\u304c\u5fdc\u7b54\u3001\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u304a\u3088\u3073 TF \u53ce\u91cf\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u8abf\u67fb\u3057\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n

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\u7d50\u679c\uff1a<\/h3>\n

\u6700\u9069\u5316\u3055\u308c\u305f\u62bd\u51fa\u6761\u4ef6\u306f\u6b21\u306e\u3068\u304a\u308a\u3067\u3059\u3002\u30a8\u30bf\u30ce\u30fc\u30eb\u6fc3\u5ea6\u300165.63%\u3002\u6eb6\u5a92\u3068\u6750\u6599\u306e\u6bd4\u300110.55:1 (ml\/g)\u3002\u62bd\u51fa\u6642\u9593\u300154.33\u5206\u3002\u78ba\u7acb\u3055\u308c\u305f\u6570\u5b66\u7684\u30e2\u30c7\u30eb\u306f\u5b9f\u9a13\u30d1\u30e9\u30e1\u30fc\u30bf\u306e\u8981\u56e0\u3092\u3088\u304f\u8aac\u660e\u3057\u3066\u304a\u308a\u3001\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3068 TF \u306e\u6700\u9069\u53ce\u7387\u3092\u7d71\u8a08\u7684\u306b\u6b63\u78ba\u306b\u4e88\u6e2c\u3067\u304d\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n

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\u7d50\u8ad6\uff1a<\/h3>\n

\u5b9f\u9a13\u5024\u306f\u3001\u78ba\u7acb\u3055\u308c\u305f\u6570\u5b66\u30e2\u30c7\u30eb\u306b\u3088\u3063\u3066\u4e88\u6e2c\u3055\u308c\u305f\u5024\u3068\u4e00\u81f4\u3057\u3001\u4f7f\u7528\u3055\u308c\u305f\u30e2\u30c7\u30eb\u304c\u9069\u5207\u3067\u3042\u308a\u3001RSM \u304c\u62bd\u51fa\u6761\u4ef6\u306e\u6700\u9069\u5316\u306b\u6210\u529f\u3057\u305f\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n<\/div>\n

\u30ad\u30fc\u30ef\u30fc\u30c9:\u00a0<\/strong>\u4e2d\u592e\u8907\u5408\u8a2d\u8a08\u3001\u62bd\u51fa\u3001Herba Polygoni Capitati\u3001\u6700\u9069\u5316\u3001\u5fdc\u7b54\u66f2\u9762\u6cd5<\/span><\/div>\n
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\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n

\u5c0e\u5165<\/h2>\n

Herba Polygoni Capitati\u3001\u306e\u5730\u4e0a\u90e8\u5206\u307e\u305f\u306f\u690d\u7269\u5168\u4f53\u00a0\u30bf\u30c7<\/em>\u00a0\u30d6\u30d5\u30cf\u30e0\u3002 ex D. Don \u306f\u3001\u4e2d\u56fd\u3001\u7279\u306b\u4e00\u90e8\u306e\u5c11\u6570\u6c11\u65cf\u5730\u57df\u3067\u3001\u4f1d\u7d71\u7684\u306a\u4e2d\u56fd\u533b\u5b66 (TCM) \u306e 1 \u3064\u3068\u3057\u3066\u9577\u3044\u9593\u4f7f\u7528\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002 Herba Polygoni Capitati \u306e\u6d3b\u6027\u5316\u5b66\u6210\u5206\u306f\u3001\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u3001\u30d5\u30a7\u30ce\u30fc\u30eb\u9178\u3001\u30bf\u30f3\u30cb\u30f3\u3068\u3057\u3066\u7279\u5b9a\u3055\u308c\u307e\u3057\u305f\u30021<\/a>,2<\/a>,3<\/a>\uff3d\u3067\u306f\u3001\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u304c\u4e3b\u8981\u306a\u751f\u7406\u6d3b\u6027\u5316\u5408\u7269\u3068\u3057\u3066\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u85ac\u7406\u5b66\u7684\u7814\u7a76\u304a\u3088\u3073\u81e8\u5e8a\u7814\u7a76\u306b\u3088\u308a\u3001\u30b1\u30eb\u30bb\u30c1\u30f3\u3068\u305d\u306e\u30b0\u30eb\u30b3\u30b7\u30c9\u306f\u6297\u304c\u3093\u4f5c\u7528\u3092\u6709\u3059\u308b\u751f\u7406\u6d3b\u6027\u5316\u5408\u7269\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u30024<\/a>,5<\/a>] \u6297\u9178\u5316[6<\/a>,7<\/a>] \u304a\u3088\u3073\u9175\u7d20\u8abf\u7bc0\u6d3b\u6027\u3002[8<\/a>,9<\/a>,10<\/a>] \u75ab\u5b66\u7814\u7a76\u3067\u306f\u3001\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9 (\u4e3b\u306b\u30b1\u30eb\u30bb\u30c1\u30f3) \u306e\u591a\u91cf\u6442\u53d6\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u3068\u306e\u9593\u306b\u9006\u76f8\u95a2\u304c\u3042\u308b\u3053\u3068\u3082\u793a\u3057\u3066\u3044\u307e\u3059\u300211<\/a>]<\/p>\n

TCM \u306e\u62bd\u51fa\u7269\u306f\u3001\u4e16\u754c\u4e2d\u3067\u4f55\u4e16\u7d00\u306b\u3082\u308f\u305f\u3063\u3066\u4f1d\u7d71\u7684\u306a\u6cbb\u7642\u6cd5\u3084\u30cf\u30fc\u30d6\u7642\u6cd5\u306b\u4f7f\u7528\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u300212<\/a>,13<\/a>\u300f\u3068\u591a\u304f\u306e\u8cb4\u91cd\u306a\u7d4c\u9a13\u304c\u3053\u306e\u6cbb\u7642\u30b7\u30b9\u30c6\u30e0\u306b\u84c4\u7a4d\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u5598\u606f\u6cbb\u7642\u85ac\u306e\u3046\u3063\u8840\u9664\u53bb\u5264\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u308b\u30a2\u30f3\u30d5\u30a7\u30bf\u30df\u30f3\u69d8\u8208\u596e\u5264\u3067\u3042\u308b\u30a8\u30d5\u30a7\u30c9\u30ea\u30f3\u306f\u3001\u4e2d\u56fd\u306e\u85ac\u8349\u304b\u3089\u62bd\u51fa\u304a\u3088\u3073\u5358\u96e2\u3055\u308c\u307e\u3057\u305f\u3002\u00a0\u30de\u30aa\u30a6<\/em>.[14<\/a>\u300f\u306e\u629c\u7c8b\u3067\u3059\u3002\u00a0\u30a4\u30c1\u30e7\u30a6<\/em>\u7279\u306b\u6a19\u6e96\u5316\u3055\u308c\u305fEGb 761\u306f\u3001\u8a8d\u77e5\u75c7\u3068\u8a8d\u77e5\u969c\u5bb3\u306b\u5bfe\u3057\u3066\u6700\u3082\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u6f22\u65b9\u85ac\u306e1\u3064\u3067\u3057\u305f\u3002[15<\/a>[16<\/a>]<\/p>\n

Herba Polygoni Capitati \u3067\u767a\u8868\u3055\u308c\u305f\u3059\u3079\u3066\u306e\u5316\u5408\u7269\u306e\u4e2d\u3067\u3001\u30d5\u30a7\u30ce\u30fc\u30eb\u9178\u3068\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u6210\u5206\u304c\u6700\u3082\u6ce8\u76ee\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u85ac\u7406\u5b66\u7684\u52b9\u679c\u304c\u91cd\u8981\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u300217<\/a>] \u4e00\u5ea6\u306b 1 \u8981\u7d20\u305a\u3064\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u307f\u306b\u3088\u308b Herba Polygoni Capitati \u304b\u3089\u306e\u6ca1\u98df\u5b50\u9178 (GA) \u307e\u305f\u306f TF \u306e\u62bd\u51fa\u3001[18<\/a>] \u307e\u305f\u306f\u76f4\u4ea4\u8a08\u753b\u306b\u95a2\u9023\u4ed8\u3051\u3089\u308c\u3066\u3044\u308b\u3001[19<\/a>\u300f\u306b\u3064\u3044\u3066\u306f\u4ee5\u524d\u306b\u3082\u304a\u4f1d\u3048\u3057\u307e\u3057\u305f\u3002\u4e00\u5ea6\u306b 1 \u3064\u306e\u56e0\u5b50\u306e\u307f\u3092\u5909\u6570\u3068\u3057\u3001\u4ed6\u306e\u3059\u3079\u3066\u306e\u56e0\u5b50\u3092\u4e00\u5b9a\u306b\u4fdd\u3064\u30a2\u30d7\u30ed\u30fc\u30c1\u3002[20<\/a>] \u306f\u6642\u9593\u304c\u304b\u304b\u308a\u3001\u56e0\u5b50\u9593\u306e\u76f8\u4e92\u4f5c\u7528\u52b9\u679c\u304c\u542b\u307e\u308c\u3066\u3044\u306a\u3044\u305f\u3081\u3001\u8aa4\u89e3\u3092\u62db\u304f\u7d50\u8ad6\u3092\u62db\u304f\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u76f4\u4ea4\u8a08\u753b\u306f\u30c6\u30b9\u30c8\u8a2d\u8a08\u306b\u5f79\u7acb\u3061\u307e\u3059[21<\/a>] \u3057\u304b\u3057\u3001\u30e2\u30c7\u30eb\u65b9\u7a0b\u5f0f\u304b\u3089\u306e\u4e88\u6e2c\u306f\u63d0\u4f9b\u3055\u308c\u307e\u305b\u3093\u3002\u7d71\u8a08\u7684\u304a\u3088\u3073\u6570\u5b66\u7684\u624b\u6cd5\u3092\u96c6\u3081\u305f\u5fdc\u7b54\u66f2\u9762\u6cd5 (RSM) \u306f\u3001\u5909\u6570\u9593\u306b\u8d77\u3053\u308a\u5f97\u308b\u76f8\u4e92\u4f5c\u7528\u52b9\u679c\u3092\u8003\u616e\u306b\u5165\u308c\u308b\u305f\u3081\u3001\u3053\u308c\u3089\u306e\u6b20\u70b9\u3092\u514b\u670d\u3067\u304d\u307e\u3059\u3002[22<\/a>,23<\/a>] \u72ec\u7acb\u3057\u305f\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u306e\u95a2\u6570\u3068\u3057\u3066\u306e\u5fdc\u7b54\u306e\u5fdc\u7b54\u66f2\u9762\u30d7\u30ed\u30c3\u30c8\u3068\u7b49\u9ad8\u7dda\u30d7\u30ed\u30c3\u30c8\u306f\u3001RSM \u306b\u3088\u3063\u3066\u53d6\u5f97\u3067\u304d\u307e\u3059\u3002[24<\/a>\u672c\u7814\u7a76\u3067\u306f\u3001\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3068TF\u306e\u53ce\u91cf\u3092\u540c\u6642\u306b\u6700\u5927\u5316\u3059\u308b\u305f\u3081\u306b\u3001RSM\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u9069\u7528\u3057\u3066Herba Polygoni Capitati\u304b\u3089\u306e\u62bd\u51fa\u6761\u4ef6\uff08\u6eb6\u5a92\u6bd4\u7387\u3001\u6eb6\u5a92\u3068\u6750\u6599\u306e\u6bd4\u7387\u3001\u62bd\u51fa\u6642\u9593\u306a\u3069\uff09\u3092\u6700\u9069\u5316\u3057\u307e\u3057\u305f\u3002<\/p>\n

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\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n

\u6750\u6599\u3068\u65b9\u6cd5<\/h2>\n
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\u6750\u6599\u3068\u5316\u5b66\u85ac\u54c1<\/h3>\n

Deyuan Chen \u6559\u6388\u306b\u3088\u3063\u3066\u690d\u7269\u5b66\u7684\u306b\u540c\u5b9a\u3055\u308c\u305f Herba Polygoni Capitati \u306f\u3001\u4e2d\u56fd\u8cb4\u5dde\u7701\u306e Guizhou Warmen Pharmaceutical Corporation \u304b\u3089\u5165\u624b\u3055\u308c\u307e\u3057\u305f\u3002 Herba Polygoni Capitati \u306e\u5168\u8349\u3092\u3001\u5f37\u5236\u5bfe\u6d41\u5f0f\u4e07\u80fd\u30aa\u30fc\u30d6\u30f3 (101-2AB Taijin\u3001\u4e2d\u56fd) \u3067 50\u00b0C \u3067 4 \u6642\u9593\u4e7e\u71e5\u3055\u305b\u307e\u3057\u305f\u3002\u4e7e\u71e5\u3057\u305f\u30b5\u30f3\u30d7\u30eb\u3092\u30ed\u30fc\u30bf\u30ea\u30fc\u30df\u30eb (DFY-200 Wenling\u3001\u4e2d\u56fd) \u3067\u7c89\u7815\u3057\u3001\u7c89\u672b\u3092\u3075\u308b\u3044\u306b\u304b\u3051\u307e\u3057\u305f\u3002\u7814\u7a76\u306e\u305f\u3081\u306b\u300110 \uff5e 40 \u30e1\u30c3\u30b7\u30e5 (\u5185\u5f84 0.3 \uff5e 2 mm) \u306e\u7c92\u5b50\u3092\u53ce\u96c6\u3057\u307e\u3057\u305f\u3002\u53c2\u7167\u5316\u5408\u7269\u306e\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3 (111538-200403) \u304a\u3088\u3073\u30eb\u30c1\u30f3 (080-9303) \u306f\u3001\u4e2d\u56fd\u751f\u7269\u533b\u85ac\u54c1\u7ba1\u7406\u56fd\u7acb\u7814\u7a76\u6240 (\u4e2d\u56fd\u3001\u5317\u4eac) \u304b\u3089\u8cfc\u5165\u3057\u307e\u3057\u305f\u3002\u30a2\u30bb\u30c8\u30cb\u30c8\u30ea\u30eb\u3068\u30e1\u30bf\u30ce\u30fc\u30eb\u306f HPLC \u30b0\u30ec\u30fc\u30c9 (Tedia\u3001\u7c73\u56fd) \u3067\u3057\u305f\u3002\u6c34\u306f\u3001\u5805\u7262\u306a\u98f2\u6599\u7528\u7d14\u6c34\uff08Le Bai Shi Food and Beverage Ltd.\u3001\u5e83\u6771\u7701\uff09\u3067\u3042\u3063\u305f\u3002\u30ae\u9178\u306f MS \u30b0\u30ec\u30fc\u30c9 (Roe Scientific Inc\u3001\u7c73\u56fd) \u3067\u3057\u305f\u3002\u4ed6\u306e\u3059\u3079\u3066\u306e\u5316\u5b66\u7269\u8cea\u3068\u6eb6\u5a92\u306f\u5206\u6790\u30b0\u30ec\u30fc\u30c9\u306e\u3082\u306e\u3067\u3042\u308a\u3001\u5e02\u8ca9\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n

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\u30b5\u30f3\u30d7\u30eb\u306e\u6e96\u5099<\/h3>\n

Herba Polygoni Capitati \u7c89\u672b 2g \u3092\u6b63\u78ba\u306b\u79e4\u91cf\u3057\u3001\u7279\u5b9a\u306e\u6761\u4ef6\u4e0b\u3067\u62bd\u51fa\u3057\u3001\u305d\u306e\u5f8c\u62bd\u51fa\u7269\u3092 3500 \u3067\u9060\u5fc3\u5206\u96e2\u3057\u307e\u3057\u305f\u3002\u00a0\u56de\u8ee2\u6570<\/em>\u00a010\u5206\u9593\u4e0a\u6e05\u3092\u53ce\u96c6\u3057\u3001\u305d\u306e\u5f8c\u306e\u5206\u6790\u306e\u305f\u3081\u306b\u6ffe\u7d19\u3067\u6ffe\u904e\u3057\u305f\u3002<\/p>\n<\/div>\n

\n

\u88c5\u7f6e<\/h3>\n

\u3053\u306e\u7814\u7a76\u3067\u4f7f\u7528\u3057\u305f\u5206\u6790\u30b7\u30b9\u30c6\u30e0\u306f\u6b21\u306e\u3068\u304a\u308a\u3067\u3059\u3002\u7d2b\u5916\u53ef\u8996\u30b9\u30da\u30af\u30c8\u30eb\u306f\u3001\u5149\u8def\u9577 1 cm \u306e\u30bb\u30eb\u3092\u5099\u3048\u305f\u30c0\u30d6\u30eb\u30d3\u30fc\u30e0\u5206\u5149\u5149\u5ea6\u8a08 (Cary 100-Varian) \u3067\u8a18\u9332\u3057\u307e\u3057\u305f\u3002\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30e0\u306e\u53d6\u5f97\u306b\u306f\u3001\u771f\u7a7a\u8131\u6c17\u88c5\u7f6e\u3001\u56db\u6b21\u30dd\u30f3\u30d7\u3001\u30aa\u30fc\u30c8\u30b5\u30f3\u30d7\u30e9\u30fc\u3001\u6052\u6e29\u30ab\u30e9\u30e0\u30b3\u30f3\u30d1\u30fc\u30c8\u30e1\u30f3\u30c8\u3001\u304a\u3088\u3073 DAD \u691c\u51fa\u5668 (DIONEX\u3001ThermoFisher\u3001\u7c73\u56fd\u30b5\u30cb\u30fc\u30d9\u30fc\u30eb) \u3067\u69cb\u6210\u3055\u308c\u308b DIONEX\/UltiMate 3000 \u30b7\u30ea\u30fc\u30ba UHPLC-DAD \u30b7\u30b9\u30c6\u30e0\u3092\u4f7f\u7528\u3057\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n

\n

\u7dcf\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u542b\u6709\u91cf\u306e\u6e2c\u5b9a<\/h3>\n

\u7dcf\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u542b\u6709\u91cf (TFC) \u306f\u3001\u524d\u8ff0\u306e\u30a2\u30eb\u30df\u30cb\u30a6\u30e0\u6bd4\u8272\u6cd5\u306b\u5f93\u3063\u3066\u6c7a\u5b9a\u3055\u308c\u307e\u3057\u305f\u300225<\/a>,26<\/a>,27<\/a>,28<\/a>\u300f\u306b\u4fee\u6b63\u3092\u52a0\u3048\u305f\u3082\u306e\u3067\u3059\u3002\u7c21\u5358\u306b\u8aac\u660e\u3059\u308b\u3068\u3001\u5404\u690d\u7269\u62bd\u51fa\u7269\u306e\u30a2\u30ea\u30b3\u30fc\u30c8 (0.5 ml) \u3092 4.3 ml \u306e\u95a2\u9023\u6eb6\u5a92\u3068\u6df7\u5408\u3057\u3001\u7d9a\u3044\u3066 0.1 ml \u306e 10% \u5869\u5316\u30a2\u30eb\u30df\u30cb\u30a6\u30e0 (AlCl) \u3092\u52a0\u3048\u307e\u3057\u305f\u30023<\/sub>) \u304a\u3088\u3073 1M \u9162\u9178\u30ca\u30c8\u30ea\u30a6\u30e0 (CH ) 0.1ml3<\/sub>\u00a0COONa\uff09\u3002\u30eb\u30c1\u30f3\u3092\u53c2\u7167\u6a19\u6e96\u3068\u3057\u3066\u4f7f\u7528\u3057\u307e\u3057\u305f\u3002\u5ba4\u6e29\u3067 30 \u5206\u9593\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30c8\u3057\u305f\u5f8c\u3001\u53cd\u5fdc\u6df7\u5408\u7269\u3092\u30d6\u30e9\u30f3\u30af\u306b\u5bfe\u3057\u3066 405nm \u3067\u6e2c\u5b9a\u3057\u307e\u3057\u305f\u3002\u5404\u30b5\u30f3\u30d7\u30eb\u306e TFC \u5024\u3092\u8a08\u7b97\u3057\u3001\u4e7e\u71e5\u6750\u6599 (DM) 1 \u30b0\u30e9\u30e0\u3042\u305f\u308a\u306e\u30eb\u30c1\u30f3\u5f53\u91cf\u306e\u30df\u30ea\u30b0\u30e9\u30e0\u3068\u3057\u3066\u8868\u3057\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n

\n

\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u306b\u3088\u308b\u5206\u96e2<\/h3>\n

\u62bd\u51fa\u7269\u306e\uff28\uff30\uff2c\uff23\u5206\u6790\u306f\u3001\uff24\uff29\uff2f\uff2e\uff25\uff38\uff0f\uff35\uff4c\uff54\uff49\uff2d\uff41\uff54\uff45 \uff13\uff10\uff10\uff10\u30b7\u30ea\u30fc\u30ba\u3092\u4f7f\u7528\u3057\u3066\u5b9f\u65bd\u3057\u305f\u3002\u5206\u96e2\u306fZORBAX SB-C\u3067\u5b9f\u884c\u3055\u308c\u307e\u3057\u305f18<\/sub>\u00a0\u30ab\u30e9\u30e0 (150 mm \u00d7 4.6 mm\u30015 \u03bcm; Agilent\u3001\u30ab\u30ea\u30d5\u30a9\u30eb\u30cb\u30a2\u5dde\u3001\u7c73\u56fd) \u3092\u6d41\u901f 1.0 ml\/min \u3067\u4f7f\u7528\u3057\u307e\u3059\u3002\u79fb\u52d5\u76f8\u306f\u3001A (\u30a2\u30bb\u30c8\u30cb\u30c8\u30ea\u30eb) \u3068 B (0.2% \u30ae\u9178\u6c34\u6eb6\u6db2) \u306e\u7d44\u307f\u5408\u308f\u305b\u304b\u3089\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u76f4\u7dda\u52fe\u914d\u306f 5% \u304b\u3089 15% A \u3067\u3057\u305f (v\/v<\/em>) 5 \u5206\u3067 16% A \u306b\u300110 \u5206\u3067 16% A \u306b\u300120 \u5206\u3067 20% A \u306b\u3001\u305d\u306e\u5f8c 22 \u5206\u9593 20% A \u306b\u4fdd\u6301\u3055\u308c\u307e\u3057\u305f\u3002\u5404\u5b9f\u884c\u306e\u5f8c\u306b 5 \u5206\u9593\u306e\u5e73\u8861\u6642\u9593\u304c\u7d9a\u304d\u307e\u3057\u305f\u3002 UV \u691c\u51fa\u5668\u306e\u6ce2\u9577\u306f 260 nm \u306b\u8a2d\u5b9a\u3057\u3001\u30ab\u30e9\u30e0\u30aa\u30fc\u30d6\u30f3\u306e\u6e29\u5ea6\u306f 30\u00b0C \u306b\u7dad\u6301\u3057\u307e\u3057\u305f\u3002\u6ce8\u5165\u524d\u306b\u30b5\u30f3\u30d7\u30eb\u3092\u6ffe\u904e\u3057\u305f(PTFE\u30b7\u30ea\u30f3\u30b8\u30d5\u30a3\u30eb\u30bf\u30fc; 0.45\u03bcm; Hanbon Ltd, China; 013045)\u3002\u30c7\u30fc\u30bf\u306f Chromeleon 7.1 \u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3067\u53ce\u96c6\u304a\u3088\u3073\u5206\u6790\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n

\n

\u6a19\u6e96\u6db2\u306e\u8abf\u88fd<\/h3>\n

\u30eb\u30c1\u30f3\u304a\u3088\u3073\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u306e\u6a19\u6e96\u30b9\u30c8\u30c3\u30af\u6eb6\u6db2\u3092\u3001\u30e1\u30bf\u30ce\u30fc\u30eb\u4e2d\u3067\u305d\u308c\u305e\u308c190.8\u03bcg\/ml\u304a\u3088\u3073106.0\u03bcg\/ml\u306e\u6fc3\u5ea6\u3067\u8abf\u88fd\u3057\u305f\u3002\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3068TF\u306e\u6a19\u6e96\u66f2\u7dda\u306f\u3001\u305d\u308c\u305e\u308c\u30d4\u30fc\u30af\u9762\u7a4d\u3068\u5438\u5149\u5ea6\u304b\u3089\u5c0e\u51fa\u3055\u308c\u305f\u7dda\u5f62\u6700\u5c0f\u4e8c\u4e57\u56de\u5e30\u5f0f\u3092\u4f7f\u7528\u3057\u3066\u6821\u6b63\u3055\u308c\u3001\u30b5\u30f3\u30d7\u30eb\u4e2d\u306e\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3068TF\u306e\u6fc3\u5ea6\u306f\u6a19\u6e96\u66f2\u7dda\u306b\u5f93\u3063\u3066\u8a08\u7b97\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n

\n

\u9069\u5207\u306a\u62bd\u51fa\u6761\u4ef6\u306e\u9078\u629e<\/h3>\n

RSM \u3092\u4f7f\u7528\u3057\u3066\u7814\u7a76\u3092\u9032\u3081\u308b\u524d\u306b\u3001\u95a2\u9023\u3059\u308b\u72ec\u7acb\u5909\u6570\u3092\u9078\u629e\u3057\u3001\u305d\u306e\u5b9f\u9a13\u7bc4\u56f2\u3092\u6c7a\u5b9a\u3059\u308b\u305f\u3081\u306b\u4e00\u9023\u306e\u4e88\u5099\u30c6\u30b9\u30c8\u304c\u5b9f\u884c\u3055\u308c\u307e\u3057\u305f\u3002\u4e88\u5099\u5b9f\u9a13\u306e\u6700\u521d\u306e\u30b9\u30c6\u30c3\u30d7\u306f\u3001Herba Polygoni Capitati \u306e\u62bd\u51fa\u306b\u9069\u5207\u306a\u65b9\u6cd5\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u3067\u3057\u305f\u3002 3 \u3064\u306e\u7570\u306a\u308b\u30a2\u30d7\u30ed\u30fc\u30c1\u3001\u3064\u307e\u308a\u6d78\u8edf\u3001\u9084\u6d41\u3001\u8d85\u97f3\u6ce2\u51e6\u7406\u62bd\u51fa\u3092\u30c6\u30b9\u30c8\u3057\u307e\u3057\u305f\u3002\u4e88\u5099\u5b9f\u9a13\u306e 2 \u756a\u76ee\u306e\u30b9\u30c6\u30c3\u30d7\u306f\u3001Herba Polygoni Capitati \u306b\u9069\u5207\u306a\u62bd\u51fa\u6eb6\u5a92\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u3067\u3057\u305f\u3002 0 \uff5e 100% \u306e\u7bc4\u56f2\u3067\u5909\u5316\u3059\u308b\u4e00\u9023\u306e\u62bd\u51fa\u6eb6\u5a92 (\u30a8\u30bf\u30ce\u30fc\u30eb\u307e\u305f\u306f\u30e1\u30bf\u30ce\u30fc\u30eb\u6c34\u6eb6\u6db2) \u3092\u4f7f\u7528\u3057\u3066\u3001\u6700\u9069\u306a\u6eb6\u5a92\u3092\u6c7a\u5b9a\u3057\u307e\u3057\u305f\u3002\u7b2c\u4e09\u306b\u3001\u6eb6\u5a92\u3068\u6750\u6599\u306e\u6bd4\u7387 (6:1\u30018:1\u300110:1\u300112:1\u300114:1;\u00a0v\/m<\/em>) \u62bd\u51fa\u6642\u306e\u30a8\u30bf\u30ce\u30fc\u30eb:\u6c34 (70:30\u3001\u00a0v\/v<\/em>) \u3092\u6eb6\u5a92\u3068\u3057\u3066\u7528\u3044\u3001\u5ba4\u6e29\u3067 30 \u5206\u9593\u306e\u8d85\u97f3\u6ce2\u51e6\u7406\u6761\u4ef6\u3067\u62bd\u51fa\u3057\u307e\u3059\u3002\u7b2c 4 \u306b\u3001\u3055\u3089\u306a\u308b\u8abf\u67fb\u306e\u305f\u3081\u306b\u9069\u5207\u306a\u7c92\u5b50\u30b5\u30a4\u30ba\u304c\u9078\u629e\u3055\u308c\u307e\u3057\u305f\u3002\u6700\u5f8c\u306b\u3001\u62bd\u51fa\u6642\u9593 (10 \u5206\u300120 \u5206\u300130 \u5206\u300140 \u5206\u300150 \u5206\u300160 \u5206) \u3082\u30c6\u30b9\u30c8\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u3053\u308c\u3089\u306e\u7d50\u679c\u306b\u57fa\u3065\u3044\u3066\u3001\u5fdc\u7b54\u30d1\u30bf\u30fc\u30f3\u3092\u5206\u6790\u3057\u3066\u30e2\u30c7\u30eb\u3092\u78ba\u7acb\u3059\u308b\u305f\u3081\u306b\u3001\u95a2\u9023\u3059\u308b\u5404\u5909\u6570\u306e 3 \u3064\u306e\u30ec\u30d9\u30eb (\u4e0b\u4f4d\u3001\u4e2d\u4f4d\u3001\u4e0a\u4f4d) \u304c\u4e2d\u592e\u8907\u5408\u8a08\u753b (CCD) \u7528\u306b\u9078\u629e\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n

\n

\u7d71\u8a08\u5206\u6790<\/h3>\n

CCD\u624b\u9806\u304b\u3089\u5f97\u3089\u308c\u305f\u5b9f\u9a13\u30c7\u30fc\u30bf\u306f\u3001RSM\u3092\u4f7f\u7528\u3057\u3066\u6b21\u306e\u4e8c\u6b21\u591a\u9805\u5f0f\u30e2\u30c7\u30eb(\u5f0f(1))\u306b\u9069\u5408\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u5206\u6790\u3055\u308c\u3001\u56de\u5e30\u4fc2\u6570\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n

\"An<\/p>\n

X \u306e\u5834\u62401<\/sub>\u3001 \u30d0\u30c42<\/sub>\u3001\u2026\u3001 \u30d0\u30c4k<\/sub>\u00a0\u5fdc\u7b54 Y \u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u30a8\u30f3\u30b3\u30fc\u30c9\u3055\u308c\u305f\u72ec\u7acb\u5909\u6570\u3067\u3059\u3002 \u03b20<\/sub>\u3001\u03b2\u79c1<\/sub>\u00a0(i = 1\u30012\u3001\u2026\u3001k)\u3001\u03b2ii<\/sub>\u00a0(i = 1, 2,\u2026, k) \u304a\u3088\u3073 \u03b2ij<\/sub>\u00a0(i = 1, 2,\u2026, k) \u306f\u3001\u305d\u308c\u305e\u308c\u5207\u7247\u9805\u3001\u7dda\u5f62\u9805\u3001\u4e8c\u6b21\u9805\u3001\u4ea4\u4e92\u4f5c\u7528\u9805\u306e\u56de\u5e30\u4fc2\u6570\u3067\u3059\u3002 k \u306f\u5909\u6570\u306e\u6570\u3067\u3059\u3002<\/p>\n

Design Expert \u30d0\u30fc\u30b8\u30e7\u30f3 8.0.5b (STAT-EASE Inc.) \u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3092\u3001\u5b9f\u9a13\u30c7\u30fc\u30bf\u306e\u56de\u5e30\u304a\u3088\u3073\u30b0\u30e9\u30d5\u5206\u6790\u306b\u4f7f\u7528\u3057\u307e\u3057\u305f\u3002\u30e2\u30c7\u30eb\u306e\u9069\u5408\u6027\u306e\u54c1\u8cea\u306f\u3001\u6c7a\u5b9a\u4fc2\u6570 (R<\/em>2<\/sup>) \u304a\u3088\u3073\u5206\u6563\u5206\u6790 (ANOVA)\u3002\u5fdc\u7b54\u66f2\u9762\u3068\u7b49\u9ad8\u7dda\u30d7\u30ed\u30c3\u30c8\u306f\u3001\u8fd1\u4f3c\u3055\u308c\u305f 2 \u6b21\u591a\u9805\u5f0f\u3092\u4f7f\u7528\u3057\u3066\u4f5c\u6210\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

 <\/p>\n<\/div>\n<\/div>\n

\n
\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n

\u7d50\u679c\u3068\u8003\u5bdf<\/h2>\n
\n

\u30b7\u30b9\u30c6\u30e0\u7cbe\u5ea6\u3001HPLC \u307e\u305f\u306f UV-Vis \u306e\u76f4\u7dda\u6027<\/h3>\n

\u62bd\u51fa\u52b9\u7387\u3092\u8a55\u4fa1\u3059\u308b\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3068TF\u3092\u6307\u5b9a\u3057\u305f\u3002\u53c2\u7167\u6a19\u6e96\u304a\u3088\u3073 Herba Polygoni Capitati \u62bd\u51fa\u7269\u306e HPLC \u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u4ee5\u4e0b\u306b\u793a\u3057\u307e\u3059\u3002\u00a0\u56f31<\/a>\u3002\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u306e\u30ec\u30d9\u30eb\u306b\u5bfe\u3059\u308b\u30d4\u30fc\u30af\u9762\u7a4d\u306e\u691c\u91cf\u7dda\u306f\u6b21\u306e\u3068\u304a\u308a\u3067\u3059\u3002\u00a0y<\/em>\u00a0= 47.622\u00a0\u30d0\u30c4<\/em>\u00a0\u2212 0.033 \uff5e 1.06 \u03bcg \u306e\u7dda\u5f62\u7bc4\u56f2\u3067 0.2231 (R<\/em>2<\/sup>\u00a0= 1.0000,\u00a0y<\/em>\u00a0= \u30d4\u30fc\u30af\u9762\u7a4d\u3068\u00a0\u30d0\u30c4<\/em>\u00a0=\u30b1\u30eb\u30b7\u30c8\u30ea\u30f3\u91cf)\u3002 TF \u91cf\u306b\u5bfe\u3059\u308b\u5438\u5149\u5ea6\u306e\u691c\u91cf\u7dda\u306f\u6b21\u306e\u3068\u304a\u308a\u3067\u3059\u3002\u00a0y<\/em>\u00a0= 0.0029\u00a0\u30d0\u30c4<\/em>\u00a0\u2013 74.32 \uff5e 267.12 \u03bcg \u306e\u7dda\u5f62\u7bc4\u56f2\u3067 0.0088 (R<\/em>2<\/sup>\u00a0= 0.9996,\u00a0y<\/em>\u00a0= \u5438\u5149\u5ea6\u3068\u00a0\u30d0\u30c4<\/em>\u00a0= TF \u91cf)\u3002<\/p>\n

\n
\"An<\/div>\n
\n
\u56f31<\/a><\/div>\n
\n

\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u306e\u8a8d\u8a3c\u6e08\u307f\u53c2\u7167\u5316\u5408\u7269 (a) \u304a\u3088\u3073 Herba Polygoni Capitati \u306e\u62bd\u51fa\u7269 (b) \u306e 260 nm \u3067\u306e HPLC \u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30e0<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\n

\u30d1\u30e9\u30e1\u30fc\u30bf\u306e\u6c7a\u5b9a\u3068\u30ec\u30d9\u30eb\u306e\u9078\u629e<\/h3>\n
\n

 <\/p>\n

\u62bd\u51fa\u65b9\u6cd5\u306e\u52b9\u679c<\/h4>\n

\u6d78\u8edf\u3001\u9084\u6d41\u3001\u8d85\u97f3\u6ce2\u51e6\u7406\u62bd\u51fa\u3092\u542b\u3080 3 \u3064\u306e\u7570\u306a\u308b\u62bd\u51fa\u65b9\u6cd5\u3092\u3001\u6b21\u306e\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u5024\u3067\u30c6\u30b9\u30c8\u3057\u307e\u3057\u305f\u3002\u7c92\u5b50\u30b5\u30a4\u30ba\u300110 \u30e1\u30c3\u30b7\u30e5\u3002\u6eb6\u5a92\u3068\u6750\u6599\u306e\u6bd4\u300110:1 (ml\/g)\u3002\u62bd\u51fa\u6642\u9593\u3001\u9084\u6d41\u304a\u3088\u3073\u8d85\u97f3\u6ce2\u62bd\u51fa\u306f 30 \u5206\u3001\u6d78\u8edf\u62bd\u51fa\u306f 12 \u6642\u9593\u3002\u6eb6\u5a92\u7d44\u6210\u300170% \u6c34\u6027\u30a8\u30bf\u30ce\u30fc\u30eb\u3002\u6e29\u5ea6\u3001\u5ba4\u6e29\u3002 DM 1 \u30b0\u30e9\u30e0\u3042\u305f\u308a\u306b\u62bd\u51fa\u3055\u308c\u305f\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3068 TF \u306e\u91cf\u306f\u3001\u6b21\u306e\u3088\u3046\u306b\u8868\u793a\u3055\u308c\u307e\u3059\u3002\u00a0\u56f32<\/a>\u3002\u5b9f\u9a13\u7d50\u679c\u306e ANOVA \u3067\u306f\u3001\u3053\u308c\u3089 3 \u3064\u306e\u62bd\u51fa\u65b9\u6cd5\u9593\u3067\u6709\u610f\u306a\u5dee\u304c\u793a\u3055\u308c\u307e\u3057\u305f (P<\/em>\u00a0< 0.01)\u3002\u4e00\u65b9\u3001\u8d85\u97f3\u6ce2\u62bd\u51fa\u6cd5\u304c\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3068TF\u306e\u53ce\u7387\u304c\u6700\u3082\u9ad8\u304b\u3063\u305f\u305f\u3081\u3001\u62bd\u51fa\u6cd5\u3068\u3057\u3066\u9078\u629e\u3057\u307e\u3057\u305f\u3002<\/p>\n

\n
\"An<\/div>\n
\n
\u56f32<\/a><\/div>\n
\n

Herba Polygoni Capitati \u304b\u3089\u306e\u30b1\u30eb\u30b7\u30c8\u30ea\u30f3 (\u5de6) \u3068 TF (\u53f3) \u306e\u3055\u307e\u3056\u307e\u306a\u62bd\u51fa\u65b9\u6cd5\u306e\u5f71\u97ff<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\n

 <\/p>\n

\u62bd\u51fa\u6eb6\u5a92\u306e\u5f71\u97ff<\/h4>\n

\u6eb6\u5a92\u306f\u5206\u6790\u7269\u306e\u56de\u53ce\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u91cd\u8981\u306a\u8981\u7d20\u3067\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u6c34\u3001\u3055\u307e\u3056\u307e\u306a\u6fc3\u5ea6\u306e\u30e1\u30bf\u30ce\u30fc\u30eb\u3001\u304a\u3088\u3073\u3055\u307e\u3056\u307e\u306a\u6fc3\u5ea6\u306e\u30a8\u30bf\u30ce\u30fc\u30eb\u3092\u30c6\u30b9\u30c8\u3057\u307e\u3057\u305f\u3002\u306b\u793a\u3059\u3088\u3046\u306b\u00a0\u56f33<\/a>60% \u6c34\u6027\u30a8\u30bf\u30ce\u30fc\u30eb\u306e\u62bd\u51fa\u52b9\u7387\u304c\u6700\u3082\u9ad8\u304b\u3063\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u3055\u3089\u306a\u308b RSM \u8abf\u67fb\u306e\u305f\u3081\u306b\u300150%\u300160%\u3001\u304a\u3088\u3073 70% \u30a8\u30bf\u30ce\u30fc\u30eb\u3092\u6eb6\u5a92\u7d44\u6210\u306e\u4e0b\u4f4d\u3001\u4e2d\u4f4d\u3001\u304a\u3088\u3073\u4e0a\u4f4d\u30ec\u30d9\u30eb\u3068\u3057\u3066\u9078\u629e\u3057\u307e\u3057\u305f\u3002<\/p>\n

\n
\"An<\/div>\n
\n
\u56f33<\/a><\/div>\n
\n

Herba Polygoni Capitati \u304b\u3089\u306e\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u304a\u3088\u3073 TF \u306e\u8d85\u97f3\u6ce2\u652f\u63f4\u62bd\u51fa\u306b\u5bfe\u3059\u308b\u6eb6\u5a92\u7d44\u6210\u306e\u5f71\u97ff<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\n

 <\/p>\n

\u6eb6\u5a92\u3068\u6750\u6599\u306e\u6bd4\u7387<\/h4>\n

\u62bd\u51fa\u306b\u5bfe\u3059\u308b\u6eb6\u5a92\u3068\u6750\u6599\u306e\u6bd4\u7387\u306e\u5f71\u97ff\u306f\u30015 \u3064\u306e\u5024 (6:1\u30018:1\u300110:1\u300112:1\u300114:1;\u00a0v\/m<\/em>\uff09\u3002\u9069\u5207\u306a\u6eb6\u5a92\u3068\u6750\u6599\u306e\u6bd4\u7387\u306e\u5024\u306f\u3001\u30eb\u30fc\u30eb\u306b\u57fa\u3065\u3044\u3066\u9078\u629e\u3055\u308c\u307e\u3059[29<\/a>] \u5024\u304c\u5c0f\u3055\u3059\u304e\u3066\u3082 (\u751f\u7406\u6d3b\u6027\u5316\u5408\u7269\u3092\u5b8c\u5168\u306b\u62bd\u51fa\u3067\u304d\u306a\u3044)\u3001\u9ad8\u3059\u304e\u3066\u3082 (\u51e6\u7406\u30b3\u30b9\u30c8\u304c\u8010\u3048\u3089\u308c\u306a\u3044) \u306f\u3044\u3051\u307e\u305b\u3093\u3002\u3067\u7d39\u4ecb\u3055\u308c\u3066\u3044\u308b\u3088\u3046\u306b\u3001\u00a0\u56f34<\/a>\u3001\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3068TF\u306e\u53ce\u91cf\u306e\u5897\u52a0\u50be\u5411\u304c\u89b3\u5bdf\u3055\u308c\u3001\u6bd4\u7387\u304c\u7d0410:1\u306e\u3068\u304d\u306b\u6700\u9ad8\u5024\u306b\u9054\u3057\u307e\u3057\u305f\u3002\u8003\u3048\u3089\u308c\u308b\u8aac\u660e\u306f\u3001\u6eb6\u5a92\u3068\u6750\u6599\u306e\u6bd4\u7387\u304c\u5897\u52a0\u3059\u308b\u3068\u3001\u7d30\u80de\u5185\u3078\u306e\u6eb6\u5a92\u306e\u62e1\u6563\u6027\u304c\u5897\u5927\u3057\u3001\u7d30\u80de\u304b\u3089\u306e\u30d5\u30a7\u30ce\u30fc\u30eb\u5316\u5408\u7269\u306e\u8131\u7740\u304c\u4fc3\u9032\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3057\u305f\u3002[30<\/a>\u672c\u7814\u7a76\u3067\u306f\u3001\u6bd4\u7387\u306e\u5024\u304c 10:1 \u3088\u308a\u9ad8\u3044\u5834\u5408\u3001\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3068 TF \u306e\u53ce\u91cf\u306e\u308f\u305a\u304b\u306a\u6e1b\u5c11\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u751f\u6210\u7269\u306e\u53ce\u96c6\u307e\u305f\u306f\u30d7\u30ed\u30bb\u30b9\u64cd\u4f5c\u306b\u304a\u3051\u308b\u640d\u5931\u304c\u5927\u304d\u304f\u306a\u3063\u305f\u3053\u3068\u304c\u539f\u56e0\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u305d\u306e\u5f8c\u306e\u7814\u7a76\u3067\u306f\u3001\u6eb6\u5a92\u3068\u6750\u6599\u306e\u6bd4\u7387\u3092 RSM \u306e\u4e2d\u9593\u30ec\u30d9\u30eb\u3068\u3057\u3066 10:1 \u306b\u8a2d\u5b9a\u3057\u307e\u3057\u305f\u3002<\/p>\n

\n
\"An<\/div>\n
\n
\u56f34<\/a><\/div>\n
\n

\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3068TF\u306e\u53ce\u7387\u306b\u5bfe\u3059\u308b\u6eb6\u5a92\u3068\u6750\u6599\u306e\u6bd4\u7387\u306e\u5f71\u97ff<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\n

 <\/p>\n

\u7c92\u5b50\u30b5\u30a4\u30ba\u306e\u5f71\u97ff<\/h4>\n

\u7c92\u5b50\u30b5\u30a4\u30ba\u3082\u8003\u616e\u3059\u3079\u304d\u91cd\u8981\u306a\u5909\u6570\u3067\u3059\u3002\u4e00\u822c\u306b\u3001\u62bd\u51fa\u52b9\u7387\u306f\u7c92\u5b50\u30b5\u30a4\u30ba\u304c\u5c0f\u3055\u304f\u306a\u308b\u307b\u3069\u5897\u52a0\u3057\u307e\u3059 [\u56f35<\/a>]\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u7c92\u5b50\u30b5\u30a4\u30ba\u306f\u76f4\u5f84 0.45 \uff5e 0.9 mm \u306b\u8a2d\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\n
\"An<\/div>\n
\n
\u56f35<\/a><\/div>\n
\n

\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u304a\u3088\u3073TF\u306e\u53ce\u91cf\u306b\u5bfe\u3059\u308b\u7c92\u5b50\u30b5\u30a4\u30ba\u306e\u5f71\u97ff<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\n

 <\/p>\n

\u62bd\u51fa\u6642\u9593\u306e\u5f71\u97ff<\/h4>\n

\u9069\u5207\u306a\u62bd\u51fa\u6642\u9593\u306e\u9078\u629e\u306f\u3001\u4e88\u5099\u7814\u7a76\u306e\u6700\u5f8c\u306e\u30b9\u30c6\u30c3\u30d7\u3067\u3057\u305f\u3002\u6700\u9069\u5024\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u300110\u300120\u300130\u300140\u300150\u3001\u304a\u3088\u3073 60 \u5206\u306e\u3055\u307e\u3056\u307e\u306a\u62bd\u51fa\u6642\u9593\u3092\u30c6\u30b9\u30c8\u3057\u307e\u3057\u305f\u3002\u7d50\u679c\u306f\u3001\u62bd\u51fa\u6642\u9593\u309210\u5206\u304b\u308950\u5206\u306b\u5ef6\u9577\u3059\u308b\u3068\u3001\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3068TF\u306e\u53ce\u91cf\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u56f36<\/a>]\u3002 50 \u5206\u306e\u30ec\u30d9\u30eb\u3067\u3001\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3068 TF \u306e\u53ce\u91cf\u306f\u6700\u9ad8\u91cf\u306b\u9054\u3057\u307e\u3057\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u62bd\u51fa\u6642\u9593\u306e\u4e0b\u4f4d\u3001\u4e2d\u4f4d\u3001\u304a\u3088\u3073\u4e0a\u4f4d\u30ec\u30d9\u30eb\u3068\u3057\u3066 40\u300150\u3001\u304a\u3088\u3073 60 \u5206\u304c\u9078\u629e\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\n
\"An<\/div>\n
\n
\u56f36<\/a><\/div>\n
\n

\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u304a\u3088\u3073TF\u306e\u53ce\u91cf\u306b\u5bfe\u3059\u308b\u62bd\u51fa\u6642\u9593\u306e\u5f71\u97ff<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\n

RSM\u306b\u3088\u308b\u62bd\u51fa\u30d1\u30e9\u30e1\u30fc\u30bf\u306e\u6700\u9069\u5316<\/h3>\n
\n

 <\/p>\n

\u91cd\u56de\u5e30\u7d50\u679c\u3068\u8fd1\u4f3c\u30e2\u30c7\u30eb\u306e\u59a5\u5f53\u6027\u306e\u5206\u6790<\/h4>\n

20 \u56de\u306e\u5b9f\u9a13\u5b9f\u884c\u304b\u3089\u306a\u308b 3 \u8981\u7d20\u304a\u3088\u3073 3 \u30ec\u30d9\u30eb\u306e\u56de\u8ee2\u53ef\u80fd\u306a CCD \u3092\u4f7f\u7528\u3057\u3001\u4e2d\u5fc3\u70b9\u3067 6 \u56de\u306e\u53cd\u5fa9\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u8aac\u660e\u3067\u304d\u306a\u3044\u5909\u52d5\u6027\u306e\u5f71\u97ff\u306f\u3001\u5b9f\u9a13\u306e\u9806\u5e8f\u3092\u30e9\u30f3\u30c0\u30e0\u5316\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u6700\u5c0f\u9650\u306b\u6291\u3048\u3089\u308c\u307e\u3057\u305f\u3002\u72ec\u7acb\u5909\u6570\u306f\u6eb6\u5a92\u7d44\u6210 (X1<\/sub>, %,\u00a0v\/v<\/em>\u3001\u30a8\u30bf\u30ce\u30fc\u30eb\/\u6c34)\u3001\u6eb6\u5a92\u3068\u6750\u6599\u306e\u6bd4\u7387 (X2<\/sub>\u3001ml\/g) \u3068\u62bd\u51fa\u6642\u9593 (X3<\/sub>\u3001min) \u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3068 TF \u53ce\u91cf\u3092\u6307\u6a19\u3068\u3057\u3066\u4f7f\u7528\u3057\u307e\u3059\u3002\u56fa\u5b9a\u7c92\u5b50\u30b5\u30a4\u30ba (0.45 \uff5e 0.9 mm) \u304c\u9078\u629e\u3055\u308c\u307e\u3057\u305f\u3002\u3059\u3079\u3066\u306e\u5b9f\u884c\u306e\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u304a\u3088\u3073 TF \u53ce\u91cf\u3092\u4ee5\u4e0b\u306b\u793a\u3057\u307e\u3059\u3002\u00a0\u88681<\/a>\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306b\u57fa\u3065\u3044\u3066\u3001\uff12\u6b21\u591a\u9805\u5f0f\u30e2\u30c7\u30eb\uff08\u5f0f\uff08\uff11\uff09\uff09\u3092\u7528\u3044\u305f\u591a\u91cd\u7dda\u5f62\u56de\u5e30\u3092\u884c\u3063\u305f\u3002<\/p>\n

 <\/p>\n

\n

\u88681<\/h3>\n
\n

\u72ec\u7acb\u5909\u6570 (X) \u306e\u5143\u306e\u30b3\u30fc\u30c9\u5316\u5f62\u5f0f\u3067\u306e\u56de\u8ee2\u53ef\u80fd\u306a\u4e2d\u592e\u8907\u5408\u8a2d\u8a08\u8a2d\u5b9a1<\/sub>\u3001 \u30d0\u30c42<\/sub>\u3001 \u30d0\u30c43<\/sub>) \u3068\u5fdc\u7b54\u5909\u6570\u3001\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u304a\u3088\u3073 TF \u306e\u5b9f\u9a13\u7d50\u679c<\/p>\n<\/div>\n

\"An<\/div>\n<\/div>\n

\u72ec\u7acb\u5909\u6570\u306e ANOVA \u3092\u56f3\u306b\u793a\u3057\u307e\u3059\u3002\u00a0\u88682<\/a>\u00a0\u3053\u308c\u3089 3 \u3064\u306e\u72ec\u7acb\u5909\u6570\u3059\u3079\u3066\u304c\u62bd\u51fa\u52b9\u7387\u306b\u5927\u304d\u304f\u5f71\u97ff\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3059 (P<\/em>\u00a0< 0.05)\u3002\u8907\u6570\u306e\u6c7a\u5b9a\u306e\u5bfe\u5fdc\u3059\u308b\u4fc2\u6570\u3092\u5099\u3048\u305f\u8fd1\u4f3c\u4e8c\u6b21\u30e2\u30c7\u30eb\u306e\u56de\u5e30\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc (R<\/em>2<\/sup>\uff09\u306b\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u00a0\u88683<\/a>\u3002\u826f\u597d\u306a\u30d5\u30a3\u30c3\u30c6\u30a3\u30f3\u30b0\u304c\u9054\u6210\u3055\u308c\u3001\u5fdc\u7b54\u306e\u5909\u52d5\u6027\u304c\u30e2\u30c7\u30eb\u306b\u3088\u3063\u3066\u8aac\u660e\u3055\u308c\u307e\u3057\u305f\u3002\u9ad8\u3044\u00a0R<\/em>2<\/sup>\u00a0\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3068 TF \u306e\u305d\u308c\u305e\u308c 0.94 \u3068 0.96 \u306e\u5024\u306f\u3001\u5b9f\u9a13\u30c7\u30fc\u30bf\u304c\u30e2\u30c7\u30eb\u306b\u3088\u3063\u3066\u4e88\u6e2c\u3055\u308c\u305f\u30c7\u30fc\u30bf\u3068\u306e\u4e92\u63db\u6027\u3092\u78ba\u8a8d\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002\u5909\u52d5\u4fc2\u6570\u306e\u4f4e\u3044\u5024 (\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u306e\u5834\u5408\u306f 1.92%\u3001TF \u306e\u5834\u5408\u306f 3.28%) \u306f\u3001\u9069\u5408\u30e2\u30c7\u30eb\u304b\u3089\u5f97\u3089\u308c\u305f\u7d50\u679c\u304c\u4fe1\u983c\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u8abf\u6574\u3055\u308c\u305f\u6c7a\u5b9a\u4fc2\u6570 (R<\/em>2<\/sup>\u00a0Adj.) \u5024\u306f\u3001\u3059\u3079\u3066\u306e * \u91cd\u8981\u306a\u7528\u8a9e\u304c\u542b\u307e\u308c\u3001\u9ad8\u3044\u5024\u306e\u5f0f\u3092\u518d\u69cb\u7bc9\u3057\u307e\u3059\u3002\u00a0R<\/em>2<\/sup>\u00a0\u8abf\u6574(R<\/em>2<\/sup>\u00a0\u8abf\u6574\u305d\u308c\u305e\u308c 87%\u300192% \u306b\u7b49\u3057\u3044) \u306f\u3001\u30e2\u30c7\u30eb\u306e\u91cd\u8981\u6027\u3092\u88cf\u4ed8\u3051\u3066\u3044\u307e\u3059\u3002<\/p>\n

 <\/p>\n

\n

\u88682<\/h3>\n
\n

\u5fdc\u7b54\u66f2\u9762\u4e8c\u6b21\u30e2\u30c7\u30eb\u306e\u5206\u6563\u5206\u6790<\/p>\n<\/div>\n

\"An<\/div>\n
<\/div>\n<\/div>\n
\n

\u88683<\/h3>\n
\n

\u5fdc\u7b54\u5909\u6570\u3001\u30b1\u30eb\u30b7\u30c8\u30ea\u30f3\u304a\u3088\u3073 TF \u306e\u4e88\u6e2c 2 \u6b21\u30e2\u30c7\u30eb\u306e\u56de\u5e30\u4fc2\u6570<\/p>\n<\/div>\n

\"An<\/div>\n<\/div>\n

\u30e2\u30c7\u30eb\u306e\u9069\u5408\u6027\u304c\u9069\u5207\u3067\u3042\u308b\u3053\u3068\u3092\u691c\u8a3c\u3059\u308b\u305f\u3081\u306b\u3001\u4e0d\u9069\u5408\u30c6\u30b9\u30c8\u304c\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u3002\u4e0d\u9069\u5408\u691c\u5b9a\u306e ANOVA \u306f\u3001\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3068 TF \u306e\u53ce\u91cf\u306b\u95a2\u3057\u3066\u6709\u610f\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f (P<\/em>\u00a0> 0.05)\u3001\u30e2\u30c7\u30eb\u304c\u5b9f\u9a13\u30c7\u30fc\u30bf\u306b\u9069\u5207\u306b\u9069\u5408\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059 [\u88684<\/a>].<\/p>\n

 <\/p>\n

\n

\u88684<\/h3>\n
\n

\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3068 TF \u306e\u4e0d\u9069\u5408\u30c6\u30b9\u30c8\u306e\u5206\u6563\u5206\u6790<\/p>\n<\/div>\n

\"An<\/div>\n<\/div>\n<\/div>\n
\n

 <\/p>\n

\u5fdc\u7b54\u66f2\u9762\u306e\u89e3\u6790<\/h4>\n

\u4ee5\u6765;\u30e2\u30c7\u30eb\u306f\u826f\u597d\u306a\u30d5\u30a3\u30c3\u30c6\u30a3\u30f3\u30b0\u3092\u793a\u3057\u3001\u5fdc\u7b54\u5024\u306f\u56de\u5e30\u5f0f\u306b\u3088\u3063\u3066\u5341\u5206\u306b\u8aac\u660e\u3055\u308c\u307e\u3059\u3002\u72ec\u7acb\u5909\u6570\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u5b9f\u8a3c\u3057\u3001\u6700\u5927\u5fdc\u7b54\u306b\u5bfe\u3059\u308b\u5404\u72ec\u7acb\u5909\u6570\u306e\u6700\u9069\u5024\u3092\u6c7a\u5b9a\u3059\u308b\u305f\u3081\u306b\u3001\u5fdc\u7b54\u66f2\u9762\u66f2\u7dda\u304c\u30d7\u30ed\u30c3\u30c8\u3055\u308c\u307e\u3057\u305f\u3002\u72ec\u7acb\u5909\u6570\u3068\u5f93\u5c5e\u5909\u6570\u306e\u9593\u306e\u95a2\u4fc2\u306f\u30013 \u6b21\u5143 (3D) \u5fdc\u7b54\u66f2\u9762\u30d7\u30ed\u30c3\u30c8\u3068 2 \u6b21\u5143 (2D) \u7b49\u9ad8\u7dda\u30d7\u30ed\u30c3\u30c8\u3067\u793a\u3055\u308c\u307e\u3057\u305f\u3002 3D \u5fdc\u7b54\u66f2\u9762\u3068 2D \u7b49\u9ad8\u7dda\u30d7\u30ed\u30c3\u30c8\u306f\u3001\u56de\u5e30\u5f0f\u306e\u30b0\u30e9\u30d5\u8868\u793a\u3068\u3057\u3066\u63d0\u4f9b\u3055\u308c\u307e\u3057\u305f [\u56f3\u00a0\u200b[\u56f37]<\/span>7<\/a>\u00a0\u305d\u3057\u3066\u00a0\u200b\u304a\u3088\u30738]\u3002<\/span>8<\/a>]\u3002\u5404\u7b49\u9ad8\u7dda\u66f2\u7dda\u306f\u30012 \u3064\u306e\u72ec\u7acb\u5909\u6570\u306e\u7121\u9650\u6570\u306e\u7d44\u307f\u5408\u308f\u305b\u3092\u8868\u3057\u3001\u3082\u3046\u4e00\u65b9\u306e\u72ec\u7acb\u5909\u6570\u306f\u9759\u6b62\u70b9\u306b\u7dad\u6301\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u3057\u3066\u30013D \u5fdc\u7b54\u66f2\u9762\u3092\u5bb9\u6613\u306b\u8996\u899a\u5316\u3067\u304d\u307e\u3059\u3002\u00a0\u56f37a<\/a>\u00a0\u6eb6\u5a92\u7d44\u6210\u304a\u3088\u3073\u6eb6\u5a92\u3068\u6750\u6599\u306e\u6bd4\u7387\u306e\u30e2\u30c7\u30eb\u306b\u3088\u3063\u3066\u5c55\u958b\u3055\u308c\u305f 3D \u5fdc\u7b54\u66f2\u9762\u95a2\u6570\u3092\u793a\u3057\u307e\u3059\u3002\u6eb6\u5a92\u7d44\u6210\u306f\u5fdc\u7b54\u306b\u5bfe\u3057\u3066\u4e8c\u6b21\u7684\u306a\u52b9\u679c\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u306e\u542b\u6709\u91cf\u306f\u300165% \u30a8\u30bf\u30ce\u30fc\u30eb\u3092\u4f7f\u7528\u3057\u305f\u3068\u304d\u306b\u6700\u9ad8\u5024\u306b\u9054\u3057\u307e\u3059\u3002\u540c\u69d8\u306b\u3001\u6eb6\u5a92\u3068\u6750\u6599\u306e\u6bd4\u7387\u306f\u3001\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u306b\u5bfe\u3059\u308b\u4e8c\u6b21\u7684\u306a\u52b9\u679c\u3082\u540c\u6642\u306b\u5b9f\u8a3c\u3057\u307e\u3057\u305f\u3002\u6eb6\u5a92\u7d44\u6210\u304a\u3088\u3073\u6eb6\u5a92\u3068\u6750\u6599\u306e\u6bd4\u7387\u304c TF \u306b\u53ca\u307c\u3059\u5f71\u97ff\u306e\u7d50\u679c\u3092\u4ee5\u4e0b\u306b\u793a\u3057\u307e\u3059\u3002\u00a0\u56f38a<\/a>\u3002\u6eb6\u5a92\u7d44\u6210\u306f\u3001\u5fdc\u7b54\u306b\u5bfe\u3057\u3066\u4e8c\u6b21\u7684\u306a\u52b9\u679c\u3092\u793a\u3057\u300160% \u3068 70% \u30a8\u30bf\u30ce\u30fc\u30eb\u306e\u9593\u3067\u6700\u5927\u5024\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002\u540c\u69d8\u306b\u3001\u6eb6\u5a92\u7d44\u6210\u3092\u56fa\u5b9a\u3057\u3066\u6eb6\u5a92\u3068\u6750\u6599\u306e\u6bd4\u7387\u3092\u5897\u52a0\u3055\u305b\u308b\u3068\u3001TF \u306f\u5f90\u3005\u306b\u5897\u52a0\u3057\u3001\u6eb6\u5a92\u3068\u6750\u6599\u306e\u6bd4\u7387\u304c\u7d04 10:1 \u306e\u3068\u304d\u306b\u6700\u9ad8\u5024\u306b\u9054\u3057\u307e\u3057\u305f\u3002<\/p>\n

\n
\"An<\/div>\n
\n
\u56f37<\/a><\/div>\n
\n

\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u306e\u53ce\u7387\u306b\u5bfe\u3059\u308b\u6eb6\u5a92\u7d44\u6210 (X1)\u3001\u6eb6\u5a92\u6750\u6599\u6bd4 (X2)\u3001\u304a\u3088\u3073\u62bd\u51fa\u6642\u9593 (X3) \u306e\u5f71\u97ff\u3092\u793a\u3059\u5fdc\u7b54\u66f2\u9762\u30d7\u30ed\u30c3\u30c8 (a\u3001c\u3001\u304a\u3088\u3073 e) \u304a\u3088\u3073\u7b49\u9ad8\u7dda\u30d7\u30ed\u30c3\u30c8 (b\u3001d\u3001f)<\/p>\n<\/div>\n<\/div>\n<\/div>\n

\n
\"An<\/div>\n
\n
\u56f38<\/a><\/div>\n
\n

TF \u306e\u53ce\u7387\u306b\u5bfe\u3059\u308b\u6eb6\u5a92\u7d44\u6210 (X1)\u3001\u6eb6\u5a92\u6750\u6599\u6bd4 (X2)\u3001\u304a\u3088\u3073\u62bd\u51fa\u6642\u9593 (X3) \u306e\u5f71\u97ff\u3092\u793a\u3059\u5fdc\u7b54\u66f2\u9762\u30d7\u30ed\u30c3\u30c8 (a\u3001c\u3001\u304a\u3088\u3073 e) \u304a\u3088\u3073\u7b49\u9ad8\u7dda\u30d7\u30ed\u30c3\u30c8 (b\u3001d\u3001f)<\/p>\n<\/div>\n<\/div>\n<\/div>\n

\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u304a\u3088\u3073TF\u53ce\u7387\u306e\u5fdc\u7b54\u5024\u306b\u5bfe\u3059\u308b\u72ec\u7acb\u5909\u6570\u6eb6\u5a92\u7d44\u6210\u304a\u3088\u3073\u62bd\u51fa\u6642\u9593\u306e\u5f71\u97ff\u3092\u56f3\u306b\u793a\u3057\u307e\u3059\u3002\u00a0\u200b\u56f37c\u3001<\/span>7c<\/a>,\u00a0\u200b\u30017d\u3001<\/span>7\u65e5<\/a>,\u00a0\u200b\u30018c\u3001<\/span>8c<\/a>,\u00a0\u200b\u30018d\u3001<\/span>8d<\/a>\u3001 \u305d\u308c\u305e\u308c\u3002 2 \u3064\u306e\u72ec\u7acb\u5909\u6570\u9593\u306e\u76f8\u4e92\u4f5c\u7528\u95a2\u4fc2\u306f\u3001\u4ed6\u306e\u72ec\u7acb\u5909\u6570\u3067\u3042\u308b\u6eb6\u5a92\u3068\u6750\u6599\u306e\u6bd4\u7387\u3092\u5b9a\u5e38\u70b9\u3067\u4e00\u5b9a\u306b\u4fdd\u3064\u3053\u3068\u306b\u3088\u3063\u3066\u751f\u6210\u3055\u308c\u305f\u7b49\u9ad8\u7dda\u30d7\u30ed\u30c3\u30c8\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u7c21\u5358\u306b\u7406\u89e3\u3067\u304d\u307e\u3059\u3002\u00a0\u200b[\u56f37d]<\/span>7\u65e5<\/a>\u00a0\u305d\u3057\u3066\u00a0\u200b\u305d\u3057\u30668d]\u3002<\/span>8d<\/a>]\u3002\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3068 TF \u306e\u53ce\u7387\u306e\u5897\u52a0\u306f\u3001\u6eb6\u5a92\u7d44\u6210\u3068\u62bd\u51fa\u6642\u9593\u306e\u5897\u52a0\u306b\u3088\u308a\u5927\u5e45\u306b\u9054\u6210\u3055\u308c\u307e\u3057\u305f\u3002\u305f\u3060\u3057\u3001\u72ec\u7acb\u5909\u6570\u304c\u7279\u5b9a\u306e\u5024\u3092\u8d85\u3048\u308b\u3068\u3001\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3068 TF \u306e\u53ce\u91cf\u306f\u5897\u52a0\u3057\u306a\u304f\u306a\u308a\u307e\u3057\u305f\u3002\u6eb6\u5a92\u7d44\u6210\u3068\u62bd\u51fa\u6642\u9593\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u3001\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u53ce\u91cf\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306b\u304a\u3044\u3066\u7d71\u8a08\u7684\u306b\u6709\u610f\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u6709\u610f\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3057\u305f (P<\/em>\u00a0< 0.01) TF \u306e\u62bd\u51fa\u306b\u5bfe\u3059\u308b\u5f71\u97ff\u3002<\/p>\n

\u6570\u5b57\u00a0\u200b\u56f37e<\/span>7e<\/a>\u00a0\u305d\u3057\u3066\u00a0\u200b\u305d\u3057\u30668e<\/span>8e<\/a>\u00a0\u306f\u3001\u6eb6\u5a92\u3068\u6750\u6599\u306e\u6bd4\u7387\u3068\u62bd\u51fa\u6642\u9593\u304c\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3068 TF \u306e\u53ce\u91cf\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u5b9f\u8a3c\u3057\u307e\u3057\u305f\u3002\u62bd\u51fa\u6642\u9593\u304a\u3088\u3073\u6eb6\u5a92-\u6750\u6599\u6bd4\u306e\u5897\u52a0\u306b\u4f34\u3044\u3001\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u304a\u3088\u3073TF\u306e\u53ce\u7387\u306e\u5897\u52a0\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u304a\u3088\u3073TF\u306e\u62bd\u51fa\u53ce\u91cf\u304c\u62bd\u51fa\u6642\u9593\u304a\u3088\u3073\u6eb6\u5a92-\u6750\u6599\u6bd4\u306b\u6bd4\u4f8b\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002 Herba Polygoni Capitati \u304b\u3089\u306e\u30b1\u30eb\u30b7\u30c8\u30ea\u30f3\u3068 TF \u306e\u62bd\u51fa\u306b\u95a2\u3059\u308b 2 \u3064\u306e\u72ec\u7acb\u5909\u6570\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u3001\u7d71\u8a08\u7684\u306b\u6709\u610f\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<\/div>\n<\/div>\n

\n

\u5b9f\u8a3c\u5b9f\u9a13<\/h3>\n

\u30e2\u30c7\u30eb\u306e\u4e88\u6e2c\u80fd\u529b\u3092\u691c\u8a3c\u3059\u308b\u305f\u3081\u306b\u3001RSM \u306e\u30ea\u30c3\u30b8\u89e3\u6790\u304b\u3089\u5c0e\u51fa\u3055\u308c\u305f\u6700\u9069\u5316\u3055\u308c\u305f\u6761\u4ef6\u4e0b\u3067\u6700\u9069\u306a\u5fdc\u7b54\u5909\u6570\u304c\u30c6\u30b9\u30c8\u3055\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u89b3\u6e2c\u5024\u306f\u30e2\u30c7\u30eb\u304b\u3089\u306e\u4e88\u6e2c\u5024\u306e 95% \u4fe1\u983c\u533a\u9593\u5185\u3067\u6e80\u8db3\u306e\u3044\u304f\u5024\u3092\u9054\u6210\u3067\u304d\u307e\u3057\u305f\u3002\u88685<\/a>].<\/p>\n

 <\/p>\n

\n

\u88685<\/h3>\n
\n

\u5fdc\u7b54\u5909\u6570\u3067\u3042\u308b\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3068TF\u306e\u4e88\u6e2c\u5024\u3068\u89b3\u6e2c\u5024\u306e\u6bd4\u8f03<\/p>\n<\/div>\n

\"An<\/div>\n
<\/div>\n<\/div>\n<\/div>\n<\/div>\n
\n
\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n

\u7d50\u8ad6<\/h2>\n

CCD \u3068\u7d44\u307f\u5408\u308f\u305b\u305f\u4e00\u5ea6\u306b 1 \u8981\u7d20\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u6eb6\u5a92\u7d44\u6210\u3001\u6eb6\u5a92\u3068\u6750\u6599\u306e\u6bd4\u7387\u3001\u62bd\u51fa\u6642\u9593\u3092\u542b\u3080\u8d85\u97f3\u6ce2\u652f\u63f4\u62bd\u51fa\u30d1\u30e9\u30e1\u30fc\u30bf\u304c\u3001Herba Polygoni Capitati \u304b\u3089\u306e\u30b1\u30eb\u30b7\u30c8\u30ea\u30f3\u3068 TF \u306e\u62bd\u51fa\u7528\u306b\u6700\u9069\u5316\u3055\u308c\u307e\u3057\u305f\u3002\u7d50\u679c\u306f\u30012 \u6b21\u591a\u9805\u5f0f\u30e2\u30c7\u30eb\u304c\u62bd\u51fa\u30c7\u30fc\u30bf\u3092\u5341\u5206\u306b\u8a18\u8ff0\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u6700\u9069\u5316\u3055\u308c\u305f\u6761\u4ef6\u306f\u6b21\u306e\u3068\u304a\u308a\u3067\u3059\u3002\u62bd\u51fa\u65b9\u6cd5\u3001\u8d85\u97f3\u6ce2\u51e6\u7406\u62bd\u51fa\u3002\u6eb6\u5a92\u306f65%\u6c34\u6027\u30a8\u30bf\u30ce\u30fc\u30eb\u3067\u4e38\u3081\u308b\u306e\u304c\u826f\u3044\u304b\u3082\u77e5\u308c\u307e\u305b\u3093\u3002\u7c92\u5b50\u30b5\u30a4\u30ba\u30010.45-0.9 mm\u3002\u6eb6\u5a92\u3068\u6750\u6599\u306e\u6bd4\u7387\u300110:1 \u306b\u4e38\u3081\u307e\u3059\u3002\u62bd\u51fa\u6642\u9593\u306f 54 \u5206\u306b\u4e38\u3081\u3089\u308c\u307e\u3059\u3002\u3053\u306e\u7814\u7a76\u306f\u3001Herba Polygoni Capitati \u306e\u5de5\u696d\u7684\u62bd\u51fa\u30d7\u30ed\u30bb\u30b9\u306b\u95a2\u3059\u308b\u57fa\u790e\u60c5\u5831\u3068\u8cb4\u91cd\u306a\u6d1e\u5bdf\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002<\/p>\n

 <\/p>\n<\/div>\n

\n
\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n

\u8b1d\u8f9e<\/h2>\n
\n

\u8457\u8005\u3089\u306f\u3001\u539f\u6750\u6599\u306e\u63d0\u4f9b\u3068\u8cb4\u5dde\u7701\u4e3b\u8981\u79d1\u5b66\u6280\u8853\u7279\u5225\u30d7\u30ed\u30b0\u30e9\u30e0 (No. 2011 6019-02)\u3001\u533b\u85ac\u54c1\u5206\u6790\u306b\u95a2\u3059\u308b\u8cb4\u5dde\u7701\u79d1\u5b66\u6280\u8853\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\u4eba\u6750\u30c1\u30fc\u30e0 (No. . 2011 4008)\u3001\u4e2d\u533b\u5b66\u306e\u8fd1\u4ee3\u5316\u306b\u95a2\u3059\u308b\u79d1\u5b66\u6280\u8853\u7523\u696d\u306e\u7814\u7a76\u958b\u767a\u306b\u95a2\u3059\u308b\u8cb4\u5dde\u7701\u7279\u5225\u30d7\u30ed\u30b0\u30e9\u30e0 (\u756a\u53f7 ZY 2011 3013)\u3001\u6f22\u65b9\u85ac\u304a\u3088\u3073\u56fd\u6c11\u85ac\u306e\u6a19\u6e96\u5316\u306e\u7279\u5fb4\u7684\u91cd\u70b9\u7814\u7a76\u5ba4\u304a\u3088\u3073\u8cb4\u5dde\u7701\u306e\u7279\u5fb4\u7684\u91cd\u70b9\u7814\u7a76\u5ba4\u770c\u6559\u80b2\u5c40\u3002 (\u756a\u53f7 KY 2012 005)\u3002<\/p>\n

 <\/p>\n<\/div>\n<\/div>\n

\n
\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n

\u811a\u6ce8<\/h2>\n<\/div>\n
\n
\n

\u30b5\u30dd\u30fc\u30c8\u6e90:<\/strong>\u00a0\u7121<\/p>\n

\u5229\u76ca\u76f8\u53cd:<\/strong>\u00a0\u4f55\u3082\u5ba3\u8a00\u3055\u308c\u3066\u3044\u306a\u3044\u3002<\/p>\n

 <\/p>\n<\/div>\n<\/div>\n

\n
\u6b21\u306e\u5834\u6240\u306b\u79fb\u52d5\u3057\u307e\u3059:<\/a><\/div>\n

\u53c2\u8003\u6587\u732e<\/h2>\n
\n
1.\u00a0Ren G\u3001Chang F\u3001Lu S\u3001Zhong H\u3001Zhang G. \u306e\u85ac\u7406\u5b66\u7684\u7814\u7a76\u00a0\u30bf\u30c7<\/em>\u00a0Buch-Ham.ex D. Don.\u00a0\u30c1\u30f3\u30fbJ\u30fb\u30c1\u30f3\u30fb\u30e1\u30fc\u30bf\u30fc\u533b\u5b66\u535a\u58eb\u3002\u00a0<\/span>1995;2<\/span>:107\u20139\u3002 28. [\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>]\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
2.\u00a0Li ML\u3001Liang B\u3001Tang JW\u3001Xie Y\u3001Zuo AP\u3001Du F. Relinqing \u9846\u7c92\u306e\u85ac\u529b\u5b66\u7814\u7a76 \u30e9\u30c3\u30c8\u306b\u304a\u3051\u308b\u6cb9\u6027\u7d30\u83cc\u6027\u814e\u76c2\u814e\u708e\u30e2\u30c7\u30eb\u3002\u00a0\u30c1\u30f3\u30fbJ\u30fb\u30c1\u30f3\u30fb\u30e1\u30fc\u30bf\u30fc\u533b\u5b66\u535a\u58eb\u3002\u00a0<\/span>2006;2<\/span>:153\u20135\u3002 [\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>]\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
3.\u00a0\u30c1\u30a7\u30f3 YS\u3001\u30ef\u30f3 JY\u3001\u30cf\u30aa JJ\u3002\u904e\u6d3b\u52d5\u8180\u80f1\u306e\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u30ea\u30ea\u30f3\u30af\u9846\u7c92\u3068\u95a2\u9023\u3057\u305f\u30c8\u30eb\u30c6\u30ed\u30b8\u30f3\u306e\u52b9\u679c\u3002\u00a0\u3042\u3054\u306e\u6cbb\u7642\u6cd5\u30af\u30ea\u30cb\u30c3\u30af\u3002\u00a0<\/span>2012;4<\/span>:500\u20131\u3002\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
4.\u00a0\u30da\u30ec\u30a4\u30e9 MA\u3001\u30b0\u30e9\u30d6\u30b9 CJ\u3001\u30d0\u30fc\u30f3\u30ba LH\u3001\u30ea\u30fc H\u3001\u30aa\u30eb\u30bd\u30f3 GR\u3001\u6c5f\u85e4 I \u4ed6\u30e9\u30c3\u30c8\u306b\u304a\u3051\u308b\u30a2\u30be\u30ad\u30b7\u30e1\u30bf\u30f3\u8a98\u767a\u7d50\u8178\u764c\u304a\u3088\u3073 7,12-\u30b8\u30e1\u30c1\u30eb\u30d9\u30f3\u30ba[a] \u30a2\u30f3\u30c8\u30e9\u30bb\u30f3\u8a98\u767a\u4e73\u764c\u306b\u5bfe\u3059\u308b\u690d\u7269\u5316\u5b66\u7269\u8cea\u3001\u30af\u30eb\u30af\u30df\u30f3\u304a\u3088\u3073\u30b1\u30eb\u30bb\u30c1\u30f3\u306e\u5f71\u97ff\u3002\u00a0\u767a\u304c\u3093\u6027\u3002\u00a0<\/span>1996;6<\/span>:1305\u201311\u3002 [\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>]\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
5.\u00a0\u30ab\u30eb\u30bf\u30b8\u30ed\u30fc\u30cd S\u3001\u30e9\u30cd\u30ec\u30c3\u30c6\u30a3 FO\u3001\u30ea\u30cd\u30c3\u30ea A\u3001\u30de\u30c3\u30b8\u30e3\u30fc\u30ce N\u3001\u30b3\u30e9\u30b5\u30f3\u30c6 A\u3001\u30e0\u30b8\u30a2\u30fc\u30cb P\u3001\u4ed6\u30d2\u30c8\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u306b\u304a\u3051\u308b\u30bf\u30e2\u30ad\u30b7\u30d5\u30a7\u30f3\u304a\u3088\u3073\u30b1\u30eb\u30bb\u30c1\u30f3\u306e II \u578b\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u7d50\u5408\u90e8\u4f4d\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u304a\u3088\u3073\u6297\u5897\u6b96\u6d3b\u6027\u3002\u00a0Am J Respir Cell Mol Biol.\u00a0<\/span>1997;1<\/span>:51\u20139\u3002 [\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>]\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
6.\u00a0Aviram M\u3001Fuhrman B. \u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u6027\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306f\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3092\u4ecb\u3057\u305f LDL \u306e\u9178\u5316\u3092\u963b\u5bb3\u3057\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u767a\u751f\u3092\u8efd\u6e1b\u3057\u307e\u3059\u3002\u00a0\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u3002\u00a0<\/span>1998;137<\/span>(\u88dc\u8db3):S45\u201350\u3002 [\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>]\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
7.\u00a0\u30e4\u30f3XL\u3001\u30ea\u30fcCQ\u3001\u30ea\u30a6YX\u3001\u30c1\u30e3\u30f3X\u3001\u30ab\u30f3WY\u3002\u30bf\u30c7\u306e\u6297\u9178\u5316\u6d3b\u6027\u3002\u00a0\u30c1\u30f3\u85ac\u5c40\u3002\u00a0<\/span>2010;39<\/span>:3659\u201361\u3002\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
8.\u00a0Siess MH\u3001Leclerc J\u3001Canivenc-Lavier MC\u3001Rat P\u3001Suschetet M. \u30d2\u30c8\u304a\u3088\u3073\u30e9\u30c3\u30c8\u306e\u809d\u81d3\u30df\u30af\u30ed\u30bd\u30fc\u30e0\u306b\u304a\u3051\u308b\u30e2\u30ce\u30aa\u30ad\u30b7\u30b2\u30ca\u30fc\u30bc\u6d3b\u6027\u306b\u5bfe\u3059\u308b\u5929\u7136\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306e\u4e0d\u5747\u4e00\u306a\u5f71\u97ff\u3002\u00a0\u6bd2\u7269\u9069\u7528\u85ac\u3002\u00a0<\/span>1995;1<\/span>:73\u20138\u3002 [\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>]\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
9.\u00a0\u30a2\u30ae\u30e5\u30ed G\u3001\u30ac\u30e1\u30c3\u30c8\u30fb\u30da\u30a4\u30e9\u30b9\u30c8\u30eb L\u3001\u30de\u30cd\u30f3\u30c6\u30a3 S\u3001\u30f4\u30a3\u30a2\u30e9 C\u3001\u30ec\u30e1\u30b8\u30fc C\u3001\u30c1\u30e3\u30c3\u30d7 H\u3001\u4ed6\u3002\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u69cb\u9020\u3068\u30db\u30b9\u30d5\u30a1\u30c1\u30b8\u30eb\u30a4\u30ce\u30b7\u30c8\u30fc\u30eb 3-\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u306e\u95a2\u4fc2: \u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u304a\u3088\u3073\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc C \u963b\u5bb3\u3068\u306e\u6bd4\u8f03\u3002\u00a0\u751f\u5316\u5b66\u85ac\u5b66\u3002\u00a0<\/span>1997;11<\/span>:1649\u201357\u3002 [\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>]\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
10.\u00a0Conseil G\u3001Baubichon-Cortay H\u3001Dayan G\u3001Jault JM\u3001Barron D\u3001Di Pietro A. \u30d5\u30e9\u30dc\u30ce\u30a4\u30c9: \u30de\u30a6\u30b9 P \u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u4e0a\u306e\u96a3\u63a5 ATP \u304a\u3088\u3073\u30b9\u30c6\u30ed\u30a4\u30c9\u7d50\u5408\u90e8\u4f4d\u3067\u4e8c\u6a5f\u80fd\u6027\u76f8\u4e92\u4f5c\u7528\u3092\u6301\u3064\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\u306e\u30af\u30e9\u30b9\u3002\u00a0Proc Natl Acad Sci US A.\u00a0<\/span>1998;17<\/span>:9831\u20136\u3002\u00a0[PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>]\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
11.\u00a0Hertog MG\u3001Kromhout D\u3001Aravanis C\u3001Blackburn H\u3001Buzina R\u3001Fidanza F\u3001\u4ed6\u3002 7\u304b\u56fd\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u6442\u53d6\u91cf\u3068\u51a0\u72b6\u52d5\u8108\u6027\u5fc3\u75be\u60a3\u304a\u3088\u3073\u304c\u3093\u306e\u9577\u671f\u30ea\u30b9\u30af\u306b\u95a2\u3059\u308b\u7814\u7a76\u3002\u00a0\u30a2\u30fc\u30c1\u30a4\u30f3\u30bf\u30fc\u30f3\u533b\u5b66\u535a\u58eb\u3002\u00a0<\/span>1995;4<\/span>:381\u20136\u3002 [\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>]\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
12.\u00a0Liyana-Pathirana C\u3001Shahidi F. \u5fdc\u7b54\u66f2\u9762\u6cd5\u3092\u4f7f\u7528\u3057\u305f\u5c0f\u9ea6\u304b\u3089\u306e\u30d5\u30a7\u30ce\u30fc\u30eb\u5316\u5408\u7269\u306e\u62bd\u51fa\u306e\u6700\u9069\u5316\u3002\u00a0\u98df\u54c1\u5316\u5b66\u3002\u00a0<\/span>2005;1<\/span>:47\u201356\u3002\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
13.\u00a0Li WL\u3001Zheng HC\u3001Bukuru J\u3001De Kimpe N. \u7cd6\u5c3f\u75c5\u306e\u6cbb\u7642\u306e\u305f\u3081\u306b\u4f1d\u7d71\u7684\u306a\u4e2d\u56fd\u533b\u5b66\u30b7\u30b9\u30c6\u30e0\u3067\u4f7f\u7528\u3055\u308c\u308b\u5929\u7136\u85ac\u3002\u00a0J \u30a8\u30b9\u30ce\u30d5\u30a1\u30fc\u30de\u30b3\u30eb\u3002\u00a0<\/span>2004;1<\/span>:1-21\u3002 [\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>]\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
14.\u00a0\u30ce\u30fc\u30de\u30a4\u30eb D. \u30a2\u30b8\u30a2\u533b\u5b66\u3002\u4f1d\u7d71\u7684\u306a\u4e2d\u56fd\u533b\u5b66\u306e\u65b0\u3057\u3044\u9854\u3002\u00a0\u79d1\u5b66\u3002\u00a0<\/span>2003;5604<\/span>:188\u201390\u3002 [\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>]\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
15.\u00a0DeFeudis FV\u3001Drieu K. \u30a4\u30c1\u30e7\u30a6\u8449\u62bd\u51fa\u7269 (EGb 761) \u304a\u3088\u3073 CNS \u6a5f\u80fd: \u57fa\u790e\u7814\u7a76\u3068\u81e8\u5e8a\u5fdc\u7528\u3002\u00a0\u73fe\u5728\u306e\u85ac\u7269\u6a19\u7684\u3002\u00a0<\/span>2000;1<\/span>:25\u201358\u3002 [\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>]\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
16.\u00a0\u30ed\u30fc\u30e9\u30f3\u30c9 I. \u6700\u9069\u306a\u6804\u990a: \u7e4a\u7dad\u3068\u690d\u7269\u5316\u5b66\u7269\u8cea\u3002\u00a0Proc Nutr Soc.\u00a0<\/span>1999;02<\/span>:415\u20139\u3002 [\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>]\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
17.\u00a0Yang BB\u3001Feng R\u3001Wang WC\u3001Zhang LY\u3001Ye XM\u3001Wang Y \u4ed6\u30df\u30e3\u30aa\u65cf\u5730\u65b9\u306e\u85ac\u8349\u3001Polygonum capitatum \u306e 3 \u3064\u306e\u6709\u52b9\u6210\u5206\u306e HPLC\/DAD\/MS \u306b\u3088\u308b\u5b9a\u91cf\u5206\u6790\u3002\u00a0\u30c1\u30f3\u30fb\u30b8\u30a7\u30a4\u30fb\u30d5\u30a1\u30fc\u30e0\u30fb\u30a2\u30ca\u30eb\u3002\u00a0<\/span>2008;11<\/span>:1793\u20136\u3002\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
18.\u00a0Xu J\u3001Zhang YP\u3001Cheng SX\u3002\u30de\u30a4\u30af\u30ed\u6ce2\u652f\u63f4\u62bd\u51fa\u306b\u95a2\u3059\u308b\u7814\u7a76\u00a0Polygonum capitatum Buch.-Ham.\u5143<\/em>\u00a0D.\u00a0\u30c9\u30f3\u30fbJ\u30fb\u30e1\u30c3\u30c9\u30fb\u30d5\u30a1\u30fc\u30e0\u30fb\u30c1\u30f3\u30fb\u30de\u30a4\u30ca\u30fc\u3002\u00a0<\/span>2012;8<\/span>:76\u20137\u3002\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
19.\u00a0Zhao XC\u3001Bai H\u3001Wang YS\u3001Liu AQ\u3001Li GQ\u3002\u30bf\u30c7\u306e\u7dcf\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306e\u62bd\u51fa\u30d7\u30ed\u30bb\u30b9\u3002\u00a0\u7acb\u5fd7\u93ae\u533b\u5b66\u7814\u7a76\u6240\u00a0<\/span>2009;11<\/span>:2815\u20136\u3002\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
20.\u00a0Silva EM\u3001Rogez H\u3001Larondelle Y. \u5fdc\u7b54\u66f2\u9762\u6cd5\u3092\u4f7f\u7528\u3057\u305f Inga edulis \u306e\u8449\u304b\u3089\u306e\u30d5\u30a7\u30ce\u30fc\u30eb\u62bd\u51fa\u306e\u6700\u9069\u5316\u3002\u00a09\u6708 \u30d4\u30e5\u30ea\u30d5\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u793e\u00a0<\/span>2007;3<\/span>:381\u20137\u3002\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
21.\u00a0Tian S\u3001Zhou X\u3001Gong H\u3001Ma X\u3001Zhang F\u3002Paeonia sinjiangensis KY Pan \u304b\u3089\u306e\u591a\u7cd6\u985e\u62bd\u51fa\u3092\u6700\u9069\u5316\u3059\u308b\u305f\u3081\u306e\u76f4\u4ea4\u30c6\u30b9\u30c8\u8a2d\u8a08\u3002\u00a0\u30d5\u30a1\u30fc\u30de\u30b3\u30fc\u30b0\u8a8c\u3002\u00a0<\/span>2011;25<\/span>:4-8\u3002\u00a0[PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>]\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
22.\u00a0Arslan-Alaton I\u3001Tureli G\u3001Olmez-Hanci T. Photo-Fenton \u306e\u3088\u3046\u306a\u9ad8\u5ea6\u306a\u9178\u5316\u30d7\u30ed\u30bb\u30b9\u3092\u4f7f\u7528\u3057\u305f\u30a2\u30be\u67d3\u6599\u88fd\u9020\u5ec3\u6c34\u306e\u51e6\u7406: \u5fdc\u7b54\u66f2\u9762\u6cd5\u306b\u3088\u308b\u6700\u9069\u5316\u3002\u00a0J \u30d5\u30a9\u30c8\u30b1\u30e0 \u30d5\u30a9\u30c8\u30d3\u30aa\u30fc\u30eb A Chem.\u00a0<\/span>2009;2-3<\/span>:142\u201353\u3002\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
23.\u00a0Tang X\u3001Yan L\u3001Gao J\u3001Ge H\u3001Yang H\u3001Lin N. \u62bd\u51fa\u30d7\u30ed\u30bb\u30b9\u306e\u6700\u9069\u5316\u3068\u6839\u304b\u3089\u306e\u591a\u7cd6\u985e\u306e\u6297\u9178\u5316\u4f5c\u7528\u306e\u8abf\u67fb\u00a0\u30ea\u30e2\u30cb\u30a6\u30e0\u30fb\u30b7\u30cd\u30f3\u30bb<\/em>\u00a0\u30af\u30f3\u30c4\u30a7\u3002\u00a0\u30d5\u30a1\u30fc\u30de\u30b3\u30fc\u30b0\u8a8c\u3002\u00a0<\/span>2011;27<\/span>:186\u201392\u3002\u00a0[PMC\u306e\u7121\u6599\u8a18\u4e8b<\/a>]<\/span>\u00a0[\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>]\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
24.\u00a0Ba\u015f D\u3001Boyac\u0131 \u0130H.\u30e2\u30c7\u30ea\u30f3\u30b0\u3068\u6700\u9069\u5316 I: \u5fdc\u7b54\u66f2\u9762\u624b\u6cd5\u306e\u6709\u7528\u6027\u3002\u00a0J \u98df\u54c1\u5de5\u5b66\u00a0<\/span>2007;3<\/span>:836\u201345\u3002\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
25.\u00a0\u30d0\u30db\u30eb\u30f3 T\u3001\u30eb\u30ad\u30b7\u30e2\u30f3\uff1d\u30e9\u30f3\u30de A\u3001\u30af\u30ed\u30b8\u30a8 A\u3001\u30a2\u30eb\u30aa\u30fc\u30de OI\u3002\u30e2\u30fc\u30ea\u30b7\u30e3\u30b9\u91ce\u83dc\u306e\u7dcf\u30d5\u30a7\u30ce\u30fc\u30eb\u3001\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u3001\u30d7\u30ed\u30a2\u30f3\u30c8\u30b7\u30a2\u30cb\u30b8\u30f3\u3001\u30d3\u30bf\u30df\u30f3 C \u30ec\u30d9\u30eb\u3068\u6297\u9178\u5316\u6d3b\u6027\u3002\u00a0J Sci \u30d5\u30fc\u30c9 \u30a2\u30b0\u30ea\u3002\u00a0<\/span>2004;12<\/span>:1553\u201361\u3002\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
26.\u00a0\u6797 JY\u3001\u5510 CY\u3002\u9078\u629e\u3057\u305f\u679c\u7269\u3068\u91ce\u83dc\u306e\u30d5\u30a7\u30ce\u30fc\u30eb\u304a\u3088\u3073\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306e\u7dcf\u542b\u6709\u91cf\u3001\u304a\u3088\u3073\u30de\u30a6\u30b9\u813e\u7d30\u80de\u306e\u5897\u6b96\u306b\u5bfe\u3059\u308b\u305d\u308c\u3089\u306e\u523a\u6fc0\u52b9\u679c\u306e\u6e2c\u5b9a\u3002\u00a0\u98df\u54c1\u5316\u5b66\u3002\u00a0<\/span>2007;1<\/span>:140\u20137\u3002\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
27.\u00a0\u30e1\u30c0A\u3001\u30e9\u30df\u30a2\u30f3CE\u3001\u30ed\u30df\u30fc\u30c8M\u3001\u30df\u30ed\u30b4J\u3001\u30ca\u30af\u30fc\u30eb\u30deOG\u3002\u30d6\u30eb\u30ad\u30ca\u30d5\u30a1\u30b5\u7523\u8702\u871c\u4e2d\u306e\u30d5\u30a7\u30ce\u30fc\u30eb\u985e\u3001\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u3001\u30d7\u30ed\u30ea\u30f3\u306e\u7dcf\u542b\u6709\u91cf\u3068\u3001\u305d\u308c\u3089\u306e\u30e9\u30b8\u30ab\u30eb\u6d88\u53bb\u6d3b\u6027\u306e\u6e2c\u5b9a\u3002\u00a0\u98df\u54c1\u5316\u5b66\u3002\u00a0<\/span>2005;3<\/span>:571\u20137\u3002\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
28.\u00a0Xie Z\u3001Zhao Y\u3001Chen P\u3001Jing P\u3001Yue J\u3001Yu L\u3002\u4e8c\u500d\u4f53\u304a\u3088\u3073\u56db\u500d\u4f53\u306e\u96cc\u6027\u690d\u7269\u306e\u8449\u304a\u3088\u3073\u5168\u8349\u30b5\u30f3\u30d7\u30eb\u4e2d\u306e\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u6307\u7d0b\u5206\u6790\u3068\u30eb\u30c1\u30f3\u304a\u3088\u3073\u30b1\u30eb\u30bb\u30c1\u30f3\u7d44\u6210\u3002\u00a0J \u8fb2\u696d\u98df\u54c1\u5316\u5b66\u3002\u00a0<\/span>2011;7<\/span>:3042\u20139\u3002 [\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>]\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
29.\u00a0Volpi N. \u7cbe\u88fd\u30d7\u30ed\u30bb\u30b9\u3078\u306e\u9ad8\u6027\u80fd\u30ad\u30e3\u30d4\u30e9\u30ea\u30fc\u96fb\u6c17\u6cf3\u52d5\u306e\u5fdc\u7528\u00a0\u5927\u8178\u83cc<\/em>\u00a0K4\u591a\u7cd6\u985e\u3002\u00a0J \u30af\u30ed\u30de\u30c8\u30ac\u30fc B.\u00a0<\/span>2004;2<\/span>:253\u20136\u3002 [\u30d1\u30d6\u30e1\u30c3\u30c9<\/a>]\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n
30.\u00a0Ray B. Enteromorpha compressa \u306e\u591a\u7cd6\u985e: \u5358\u96e2\u3001\u7cbe\u88fd\u3001\u304a\u3088\u3073\u69cb\u9020\u7684\u7279\u5fb4\u3002\u00a0\u70ad\u6c34\u5316\u7269\u30dd\u30ea\u30de\u30fc\u3002\u00a0<\/span>2006;3<\/span>:408\u201316\u3002\u00a0[Google \u30b9\u30ab\u30e9\u30fc<\/a>]<\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n
<\/div>\n
<\/div>\n
\u30bd\u30fc\u30b9<\/a><\/div>","protected":false},"excerpt":{"rendered":"

Polygonum capitatum, known as “Tou Hua Liao” (Chinese name), is a crucial source of Hmong medicinal plants that has benefited human health for a long time. This folk-medicinal plant is widely distributed in the south-west of China for the treatment of various urologic disorders including urinary tract infections, pyelonephritis, and urinary calculus. <\/p>","protected":false},"author":1,"featured_media":5353,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9],"tags":[],"class_list":["post-5191","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-supplements"],"_links":{"self":[{"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/posts\/5191","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/comments?post=5191"}],"version-history":[{"count":1,"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/posts\/5191\/revisions"}],"predecessor-version":[{"id":5354,"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/posts\/5191\/revisions\/5354"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/media\/5353"}],"wp:attachment":[{"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/media?parent=5191"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/categories?post=5191"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/directcm.com\/ja\/wp-json\/wp\/v2\/tags?post=5191"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}