{"id":5097,"date":"2024-01-15T12:23:02","date_gmt":"2024-01-15T12:23:02","guid":{"rendered":"https:\/\/farlong.com\/?p=5097"},"modified":"2024-01-27T10:21:00","modified_gmt":"2024-01-27T10:21:00","slug":"optimization-of-quercitrin-and-total-flavonoids-extraction-from-herba-polygoni-capitati-by-response-surface-methodology","status":"publish","type":"post","link":"https:\/\/directcm.com\/ko\/optimization-of-quercitrin-and-total-flavonoids-extraction-from-herba-polygoni-capitati-by-response-surface-methodology\/","title":{"rendered":"\ubc18\uc751 \ud45c\uba74 \ubc29\ubc95\ub860\uc744 \ud1b5\ud55c Herba Polygoni Capitati\uc758 \ud018\ub974\uc2dc\ud2b8\ub9b0 \ubc0f \ucd1d \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc \ucd94\ucd9c \ucd5c\uc801\ud654"},"content":{"rendered":"
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\ucd94\uc0c1\uc801\uc778<\/h2>\n
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\ubaa9\uc801:<\/h3>\n

 <\/p>\n

\ubc18\uc751 \ud45c\uba74 \ubc29\ubc95\ub860(RSM)\uc744 \uc0ac\uc6a9\ud558\uc5ec Herba Polygoni Capitati(\uc911\uad6d\uc5b4\ub85c Touhualiao)\uc5d0\uc11c \ud018\ub974\uc2dc\ud2b8\ub9b0 \ubc0f \ucd1d \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc(TF) \ucd94\ucd9c \uc870\uac74\uc744 \ucd5c\uc801\ud654\ud569\ub2c8\ub2e4.<\/p>\n<\/div>\n

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\uc7ac\ub8cc \ubc0f \ubc29\ubc95:<\/h3>\n

 <\/p>\n

\uc6a9\ub9e4 \uc870\uc131(%), \uc6a9\ub9e4-\uc7ac\ub8cc \ube44\uc728(ml\/g) \ubc0f \ucd94\ucd9c \uc2dc\uac04(\ubd84)\uc744 \ud3ec\ud568\ud55c \uc138 \uac00\uc9c0 \ub3c5\ub9bd \ubcc0\uc218\uac00 \ubc18\uc751, \ud018\ub974\uc2dc\ud2b8\ub9b0 \ubc0f TF \uc218\uc728\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \uc870\uc0ac\ud558\uae30 \uc704\ud574 \uc911\uc559 \ubcf5\ud569 \uc124\uacc4(CCD)\ub97c \ucc44\ud0dd\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<\/div>\n

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\uacb0\uacfc:<\/h3>\n

 <\/p>\n

\ucd5c\uc801\ud654\ub41c \ucd94\ucd9c \uc870\uac74\uc740 \ub2e4\uc74c\uacfc \uac19\uc2b5\ub2c8\ub2e4: \uc5d0\ud0c4\uc62c \ub18d\ub3c4, 65.63%; \uc6a9\ub9e4-\ubb3c\uc9c8 \ube44\uc728, 10.55:1(ml\/g); \ucd94\ucd9c \uc2dc\uac04, 54.33\ubd84. \ud655\ub9bd\ub41c \uc218\ud559\uc801 \ubaa8\ub378\uc740 \uc2e4\ud5d8 \ub9e4\uac1c\ubcc0\uc218\uc758 \uc694\uc778\uc744 \uc798 \uc124\uba85\ud558\uace0 \ud018\ub974\uc2dc\ud2b8\ub9b0\uacfc TF\uc758 \ucd5c\uc801 \uc218\uc728\uc5d0 \ub300\ud55c \ud1b5\uacc4\uc801\uc73c\ub85c \uc815\ud655\ud55c \uc608\uce21\uc744 \uc81c\uacf5\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<\/div>\n

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\uacb0\ub860:<\/h3>\n

 <\/p>\n

\uc2e4\ud5d8\uac12\uc740 \ud655\ub9bd\ub41c \uc218\ud559\uc801 \ubaa8\ub378\uc5d0 \uc758\ud574 \uc608\uce21\ub41c \uac12\uacfc \uc77c\uce58\ud558\uc5ec \uc0ac\uc6a9\ub41c \ubaa8\ub378\uc758 \uc801\ud569\uc131\uacfc \ucd94\ucd9c \uc870\uac74 \ucd5c\uc801\ud654\uc5d0 \uc788\uc5b4 RSM\uc758 \uc131\uacf5\uc744 \ub098\ud0c0\ub0c5\ub2c8\ub2e4.<\/p>\n<\/div>\n<\/div>\n

\ud0a4\uc6cc\ub4dc:\u00a0<\/strong>\uc911\uc2ec\ud569\uc131\uc124\uacc4, \ucd94\ucd9c, Herba Polygoni Capitati, \ucd5c\uc801\ud654, \ubc18\uc751\ud45c\uba74\ubc29\ubc95\ub860<\/span><\/div>\n
<\/div>\n<\/div>\n
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\uc774\ub3d9 :<\/a><\/div>\n

\uc18c\uac1c<\/h2>\n

 <\/p>\n

Herba Polygoni Capitati, \uc2dd\ubb3c\uc758 \uacf5\uc911 \ubd80\ubd84 \ub610\ub294 \uc804\uccb4\u00a0\ub2e4\uac01\ud615 capitatum<\/em>\u00a0\ubd80\ud750.-\ud584. ex D. Don\uc740 \uc911\uad6d, \ud2b9\ud788 \uc77c\ubd80 \uc18c\uc218\ubbfc\uc871 \uc9c0\uc5ed\uc5d0\uc11c \uc624\ub7ab\ub3d9\uc548 \ud55c\uc57d(TCM) \uc911 \ud558\ub098\ub85c \uc0ac\uc6a9\ub418\uc5b4 \uc654\uc2b5\ub2c8\ub2e4. Herba Polygoni Capitati\uc758 \ud65c\uc131 \ud654\ud559 \uc131\ubd84\uc740 \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc, \ud398\ub180\uc0b0 \ubc0f \ud0c4\ub2cc\uc73c\ub85c \ud655\uc778\ub418\uc5c8\uc2b5\ub2c8\ub2e4.1<\/a>,2<\/a>,3<\/a>] \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc\uac00 \uc8fc\uc694 \uc0dd\ub9ac \ud65c\uc131 \ud654\ud569\ubb3c\ub85c \uac04\uc8fc\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc57d\ub9ac\ud559\uc801 \ubc0f \uc784\uc0c1 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \ud018\ub974\uc138\ud2f4\uacfc \uadf8 \uae00\ub8e8\ucf54\uc0ac\uc774\ub4dc\ub294 \ud56d\uce74\ub9b0\uc6d0\uc131\uc744 \uc9c0\ub2cc \uc0dd\ub9ac\ud65c\uc131 \ud654\ud569\ubb3c\uc774\uc5c8\uc2b5\ub2c8\ub2e4.4<\/a>,5<\/a>] \ud56d\uc0b0\ud654[6<\/a>,7<\/a>] \ubc0f \ud6a8\uc18c \uc870\uc808 \ud65c\uc131.[8<\/a>,9<\/a>,10<\/a>] \uc5ed\ud559 \uc5f0\uad6c\uc5d0\uc11c\ub3c4 \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc(\uc8fc\ub85c \ucf00\ub974\uc138\ud2f4)\uc758 \uacfc\ub2e4 \uc12d\ucde8\uc640 \uc2ec\ud608\uad00 \uc9c8\ud658 \uc0ac\uc774\uc758 \uc5ed\uc758 \uad00\uacc4\uac00 \ubc1d\ud600\uc84c\uc2b5\ub2c8\ub2e4.[11<\/a>]<\/p>\n

TCM \ucd94\ucd9c\ubb3c\uc740 \uc804 \uc138\uacc4\uc801\uc73c\ub85c \uc218\uc138\uae30 \ub3d9\uc548 \uc804\ud1b5\uc801\uc778 \uce58\ub8cc\ubc95\uacfc \uc57d\ucd08 \uc694\ubc95\uc5d0 \uc0ac\uc6a9\ub418\uc5b4 \uc654\uc2b5\ub2c8\ub2e4.12<\/a>,13<\/a>] \uadf8\ub9ac\uace0 \uc774 \uce58\ub8cc \uc2dc\uc2a4\ud15c\uc5d0\ub294 \uadc0\uc911\ud55c \uacbd\ud5d8\uc774 \ub9ce\uc774 \ucd95\uc801\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4. \ucc9c\uc2dd\uce58\ub8cc\uc758 \ucda9\ud608\uc644\ud654\uc81c\ub85c \uc0ac\uc6a9\ub418\ub294 \uc554\ud398\ud0c0\ubbfc \uc720\uc0ac \uc790\uadf9\uc81c\uc778 \uc5d0\ud398\ub4dc\ub9b0\uc740 \ud55c\uc57d\uc7ac\uc5d0\uc11c \ucd94\ucd9c \ubd84\ub9ac\ub418\uc5c8\uc2b5\ub2c8\ub2e4.\u00a0\uc5d0\ud398\ub4dc\ub77c \ud5c8\ube0c<\/em>.[14<\/a>]\uc758 \ucd94\ucd9c\ubb3c\u00a0\uc740\ud589 \ub098\ubb34<\/em>\ud2b9\ud788 \ud45c\uc900\ud654\ub41c EGb 761\uc740 \uce58\ub9e4 \ubc0f \uc778\uc9c0 \uc7a5\uc560\uc5d0 \uac00\uc7a5 \ub110\ub9ac \uc0ac\uc6a9\ub418\ub294 \uc57d\ucd08 \uc694\ubc95 \uc911 \ud558\ub098\uc600\uc2b5\ub2c8\ub2e4.15<\/a>] \uc6a9\ub9e4 \uc870\uc131, \ucd94\ucd9c \uc2dc\uac04, \ucd94\ucd9c \uc628\ub3c4, \uc6a9\ub9e4-\ubb3c\uc9c8 \ube44\uc728\uacfc \uac19\uc740 \ub9ce\uc740 \uc694\uc18c\uac00 \ucd94\ucd9c \ud6a8\ub2a5\uc5d0 \ud070 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\uc73c\ubbc0\ub85c \ucd94\ucd9c \ub9e4\uac1c\ubcc0\uc218\ub294 \uc778\uac04 \ub300\uc0c1\uc5d0\uc11c \uc608\ubc29\uc801 \ub610\ub294 \uce58\ub8cc\uc801 \uac00\uce58\uac00 \uc788\ub294 \ub354 \ub9ce\uc740 \uc131\ubd84\uc744 \uc5bb\uae30 \uc704\ud574 \ucd5c\uc801\ud654\ub418\uc5b4\uc57c \ud569\ub2c8\ub2e4.[16<\/a>]<\/p>\n

Herba Polygoni Capitati\uc5d0 \uc81c\uc2dc\ub41c \ubaa8\ub4e0 \ud654\ud569\ubb3c \uc911\uc5d0\uc11c \ud398\ub180\uc0b0\uacfc \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc \uc131\ubd84\uc774 \uac00\uc7a5 \ub9ce\uc740 \uad00\uc2ec\uc744 \ubc1b\uc558\uc73c\uba70 \uc57d\ub9ac\ud559\uc801 \ud6a8\uacfc\uc5d0 \uc911\uc694\ud55c \uac83\uc73c\ub85c \uac04\uc8fc\ub418\uc5c8\uc2b5\ub2c8\ub2e4.17<\/a>] \ud55c \ubc88\uc5d0 1\uc778\uc790 \uc811\uadfc \ubc29\uc2dd\ub9cc\uc73c\ub85c Herba Polygoni Capitati\uc5d0\uc11c \uac08\uc0b0(GA) \ub610\ub294 TF\ub97c \ucd94\ucd9c\ud569\ub2c8\ub2e4.[18<\/a>] \ub610\ub294 \uc9c1\uad50 \ub514\uc790\uc778\uacfc \uc5f0\uad00\ub428,[19<\/a>]\uac00 \uc774\uc804\uc5d0 \ubcf4\uace0\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ud55c \ubc88\uc5d0 \ud558\ub098\uc758 \uc694\uc778\ub9cc \uac00\ubcc0\ud558\ub294 \uc811\uadfc\ubc95\uc740 \ub2e4\ub978 \ubaa8\ub4e0 \uc694\uc778\uc740 \uc77c\uc815\ud558\uac8c \uc720\uc9c0\ud558\uba74\uc11c \ud55c \ubc88\uc5d0 \ud558\ub098\uc758 \uc694\uc778\ub9cc \uac00\ubcc0\ud569\ub2c8\ub2e4.[20<\/a>] \uc2dc\uac04\uc774 \ub9ce\uc774 \uac78\ub9ac\uace0 \uc694\uc778 \uac04\uc758 \uc0c1\ud638 \uc791\uc6a9 \ud6a8\uacfc\ub97c \ud3ec\ud568\ud558\uc9c0 \uc54a\uae30 \ub54c\ubb38\uc5d0 \uc798\ubabb\ub41c \uacb0\ub860\uc744 \ub0b4\ub9b4 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc9c1\uad50 \uc124\uacc4\ub294 \ud14c\uc2a4\ud2b8 \uc124\uacc4\uc5d0 \uc720\uc6a9\ud569\ub2c8\ub2e4.21<\/a>] \uadf8\ub7ec\ub098 \ubaa8\ub378 \ubc29\uc815\uc2dd\uc73c\ub85c\ubd80\ud130 \uc608\uce21\uc744 \uc81c\uacf5\ud558\uc9c0\ub294 \uc54a\uc2b5\ub2c8\ub2e4. \ud1b5\uacc4 \ubc0f \uc218\ud559\uc801 \uae30\uc220\uc758 \ubaa8\uc74c\uc778 \ubc18\uc751 \ud45c\uba74 \ubc29\ubc95\ub860(RSM)\uc740 \ubcc0\uc218 \uac04\uc758 \uac00\ub2a5\ud55c \uc0c1\ud638 \uc791\uc6a9 \ud6a8\uacfc\ub97c \uc124\uba85\ud558\ubbc0\ub85c \uc774\ub7ec\ud55c \ub2e8\uc810\uc744 \uadf9\ubcf5\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.[22<\/a>,23<\/a>] \ub3c5\ub9bd \ub9e4\uac1c\ubcc0\uc218\uc758 \ud568\uc218\ub85c\uc11c \ubc18\uc751\uc758 \ubc18\uc751 \ud45c\uba74 \ud50c\ub86f\uacfc \ub4f1\uace0\uc120 \ud50c\ub86f\uc740 RSM\uc73c\ub85c \uc5bb\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4.[24<\/a>] \ubcf8 \uc5f0\uad6c\uc5d0\uc11c\ub294 \ud018\ub974\uc2dc\ud2b8\ub9b0\uacfc TF\uc758 \ub3d9\uc2dc \uc218\uc728\uc744 \uadf9\ub300\ud654\ud558\uae30 \uc704\ud574 Herba Polygoni Capitati\ub85c\ubd80\ud130 \ucd94\ucd9c \uc870\uac74(\uc6a9\ub9e4 \ube44\uc728, \uc6a9\ub9e4-\ubb3c\uc9c8 \ube44\uc728, \ucd94\ucd9c \uc2dc\uac04 \ub4f1)\uc744 \ucd5c\uc801\ud654\ud558\ub294 RSM \uc811\uadfc\ubc95\uc744 \uc801\uc6a9\ud558\uc600\ub2e4.<\/p>\n

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\uc774\ub3d9 :<\/a><\/div>\n

\uc7ac\ub8cc \ubc0f \ubc29\ubc95<\/h2>\n

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\uc7ac\ub8cc \ubc0f \ud654\ud559\ubb3c\uc9c8<\/h3>\n

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Deyuan Chen \uad50\uc218\uac00 \uc2dd\ubb3c\ud559\uc801\uc73c\ub85c \ud655\uc778\ud55c Herba Polygoni Capitati\ub294 \uc911\uad6d \uad6c\uc774\uc800\uc6b0\uc5d0 \uc788\ub294 Guizhou Warmen Pharmaceutical Corporation\uc5d0\uc11c \uad6c\uc785\ud588\uc2b5\ub2c8\ub2e4. Herba Polygoni Capitati\uc758 \uc804\uccb4 \uc2dd\ubb3c\uc744 \uac15\uc81c \ub300\ub958\uac00 \uac00\ub2a5\ud55c \ubc94\uc6a9 \uc624\ube10(101-2AB Taijin, \uc911\uad6d)\uc5d0\uc11c 50\u00b0C\uc5d0\uc11c 4\uc2dc\uac04 \ub3d9\uc548 \uac74\uc870\ud588\uc2b5\ub2c8\ub2e4. \uac74\uc870\ub41c \uc2dc\ub8cc\ub97c \ud68c\uc804\ubc00(DFY-200 Wenling, China)\uc5d0\uc11c \ubd84\uc1c4\ud558\uace0 \ubd84\ub9d0\uc744 \uccb4\uc9c8\ud558\uc600\ub2e4. \uc5f0\uad6c\ub97c \uc704\ud574 10~40 mesh(0.3~2mm, id) \ud06c\uae30\uc758 \uc785\uc790\ub97c \uc218\uc9d1\ud588\uc2b5\ub2c8\ub2e4. \ucc38\uc870 \ud654\ud569\ubb3c\uc778 \ud018\ub974\uc2dc\ud2b8\ub9b0(111538-200403)\uacfc \ub8e8\ud2f4(080-9303)\uc740 \uc911\uad6d \uad6d\ub9bd\uc0dd\ubb3c\uc758\uc57d\ud488\ud1b5\uc81c\uc5f0\uad6c\uc18c(\uc911\uad6d \ubca0\uc774\uc9d5)\uc5d0\uc11c \uad6c\uc785\ud588\uc2b5\ub2c8\ub2e4. \uc544\uc138\ud1a0\ub2c8\ud2b8\ub9b4\uacfc \uba54\ud0c4\uc62c\uc740 HPLC \ub4f1\uae09(Tedia, USA)\uc774\uc5c8\uc2b5\ub2c8\ub2e4. \ubb3c\uc740 \uc21c\uc218\ud55c \ubb3c\uc744 \ub9c8\uc2dc\ub294 \ub370\uc5d0 \uac15\ud588\uc2b5\ub2c8\ub2e4(\uad11\ub465 \uc18c\uc7ac Le Bai Shi Food and Beverage Ltd.). \ud3ec\ub984\uc0b0\uc740 MS \ub4f1\uae09(Roe Scientific Inc, USA)\uc774\uc5c8\uc2b5\ub2c8\ub2e4. \ub2e4\ub978 \ubaa8\ub4e0 \ud654\ud559 \ubb3c\uc9c8\uacfc \uc6a9\ub9e4\ub294 \ubd84\uc11d \ub4f1\uae09\uc774\uc5c8\uc73c\uba70 \uc0c1\uc5c5\uc801\uc73c\ub85c \uc774\uc6a9 \uac00\ub2a5\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

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\uc0d8\ud50c \uc900\ube44<\/h3>\n

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\ud5c8\ubc14\ud3f4\ub9ac\uace0\ub2c8\uce74\ud53c\ud0c0\ud2f0 \ubd84\ub9d0 2g\uc744 \uc815\ubc00\ud788 \ub2ec\uc544 \uc77c\uc815\ud55c \uc870\uac74\uc5d0\uc11c \ucd94\ucd9c\ud55c \ud6c4 3500\u2103\uc5d0\uc11c \uc6d0\uc2ec\ubd84\ub9ac\ud558\uc600\ub2e4.\u00a0rpm<\/em>\u00a010\ubd84 \ub3d9\uc548. \ud6c4\uc18d \ubd84\uc11d\uc744 \uc704\ud574 \uc0c1\uccad\uc561\uc744 \uc218\uc9d1\ud558\uace0 \uc5ec\uacfc\uc9c0\ub97c \ud1b5\ud574 \uc5ec\uacfc\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

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\uae30\uad6c<\/h3>\n

 <\/p>\n

\ubcf8 \uc5f0\uad6c\uc5d0 \uc0ac\uc6a9\ub41c \ubd84\uc11d \uc2dc\uc2a4\ud15c\uc740 \ub2e4\uc74c\uacfc \uac19\uc2b5\ub2c8\ub2e4. UV-Vis \uc2a4\ud399\ud2b8\ub7fc\uc740 \uacbd\ub85c \uae38\uc774\uac00 1cm\uc778 \uc140\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc774\uc911 \ube54 \ubd84\uad11 \uad11\ub3c4\uacc4(Cary 100-Varian)\uc5d0\uc11c \uae30\ub85d\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc9c4\uacf5 \ud0c8\uae30 \uc7a5\uce58, 4\ucc28 \ud38c\ud504, \uc790\ub3d9 \uc0d8\ud50c\ub7ec, \uc628\ub3c4 \uc870\uc808 \uceec\ub7fc \uad6c\ud68d \ubc0f DAD \uac80\ucd9c\uae30\ub85c \uad6c\uc131\ub41c DIONEX\/UltiMate 3000 \uc2dc\ub9ac\uc988 UHPLC-DAD \uc2dc\uc2a4\ud15c(DIONEX, ThermoFisher, Sunnyvale, USA)\uc744 \uc0ac\uc6a9\ud558\uc5ec \ud06c\ub85c\ub9c8\ud1a0\uadf8\ub7a8\uc744 \ud68d\ub4dd\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

 <\/p>\n<\/div>\n

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\ucd1d \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc \ud568\ub7c9 \uce21\uc815<\/h3>\n

 <\/p>\n

\ucd1d \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc \ud568\ub7c9(TFC)\uc740 \uc774\uc804\uc5d0 \uc124\uba85\ud55c \uc54c\ub8e8\ubbf8\ub284 \ube44\uc0c9\ubc95\uc5d0 \ub530\ub77c \uacb0\uc815\ub418\uc5c8\uc2b5\ub2c8\ub2e4.25<\/a>,26<\/a>,27<\/a>,28<\/a>] \uc218\uc815\ud588\uc2b5\ub2c8\ub2e4. \uac04\ub7b5\ud558\uac8c \ub9d0\ud558\uba74, \uac01 \uc2dd\ubb3c\ucd94\ucd9c\ubb3c 0.5ml\ub97c \uad00\ub828\uc6a9\ub9e4 4.3ml\uc640 \ud63c\ud569\ud55c \ud6c4, 10% \uc5fc\ud654\uc54c\ub8e8\ubbf8\ub284(AlCl) 0.1ml\ub97c \ucca8\uac00\ud558\uc600\ub2e4.3<\/sub>) \ubc0f 1M \uc544\uc138\ud2b8\uc0b0\ub098\ud2b8\ub968(CH) 0.1ml3<\/sub>\u00a0\ucfe0\ub098). \ub8e8\ud2f4(Rutin)\uc744 \ucc38\uc870 \ud45c\uc900\uc73c\ub85c \uc0ac\uc6a9\ud588\uc2b5\ub2c8\ub2e4. \uc2e4\uc628\uc5d0\uc11c 30\ubd84 \ub3d9\uc548 \ubc30\uc591\ud55c \ud6c4, \ubc18\uc751 \ud63c\ud569\ubb3c\uc744 \ube14\ub7ad\ud06c\uc5d0 \ub300\ud574 405nm\uc5d0\uc11c \uce21\uc815\ud588\uc2b5\ub2c8\ub2e4. \uac01 \uc0d8\ud50c\uc758 TFC \uac12\uc744 \uacc4\uc0b0\ud558\uace0 \uac74\uc870\ub41c \ubb3c\uc9c8 \uadf8\ub7a8\ub2f9 \ub8e8\ud2f4 \ub2f9\ub7c9\uc758 \ubc00\ub9ac\uadf8\ub7a8(DM)\uc73c\ub85c \ud45c\uc2dc\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

 <\/p>\n<\/div>\n

\n

\ud06c\ub85c\ub9c8\ud1a0\uadf8\ub798\ud53c \ubd84\ub9ac<\/h3>\n

 <\/p>\n

\ucd94\ucd9c\ubb3c\uc758 HPLC \ubd84\uc11d\uc740 DIONEX\/UltiMate 3000 \uc2dc\ub9ac\uc988\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc218\ud589\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ubd84\ub9ac\ub294 ZORBAX SB-C\uc5d0\uc11c \uc218\ud589\ub418\uc5c8\uc2b5\ub2c8\ub2e4.18<\/sub>\u00a0\uc720\uc18d 1.0ml\/min\uc758 \uceec\ub7fc(150mm \u00d7 4.6mm, 5\u03bcm, Agilent, CA, USA). \uc774\ub3d9\uc0c1\uc740 A(\uc544\uc138\ud1a0\ub2c8\ud2b8\ub9b4)\uc640 B(\ubb3c \uc911 0.2% \ud3ec\ub984\uc0b0)\uc758 \uc870\ud569\uc73c\ub85c \uad6c\uc131\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc120\ud615 \uad6c\ubc30\ub294 5%\uc5d0\uc11c 15% A(v\/v<\/em>) 5\ubd84\uc5d0 16% A\ub85c, 10\ubd84\uc5d0 16%A\ub85c, 20\ubd84\uc5d0 20%A\ub85c, \uc774\uc5b4\uc11c 20%A\ub85c 22\ubd84 \ub3d9\uc548 \uc720\uc9c0\ud588\uc2b5\ub2c8\ub2e4. \uac01 \uc2e4\ud589 \ud6c4\uc5d0\ub294 5\ubd84\uc758 \ud3c9\ud615 \uc2dc\uac04\uc774 \uc18c\uc694\ub418\uc5c8\uc2b5\ub2c8\ub2e4. UV \uac80\ucd9c\uae30\uc758 \ud30c\uc7a5\uc740 260nm\ub85c \uc124\uc815\ub418\uc5c8\uace0, \uceec\ub7fc \uc624\ube10\uc758 \uc628\ub3c4\ub294 30\u00b0C\ub85c \uc720\uc9c0\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc8fc\uc785 \uc804\uc5d0 \uc0d8\ud50c\uc744 \uc5ec\uacfc\ud588\uc2b5\ub2c8\ub2e4 (PTFE \uc8fc\uc0ac\uae30 \ud544\ud130; 0.45 \u03bcm; Hanbon Ltd, China; 013045). \ub370\uc774\ud130\ub294 Chromeleon 7.1 \uc18c\ud504\ud2b8\uc6e8\uc5b4\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc218\uc9d1 \ubc0f \ubd84\uc11d\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n

 <\/p>\n<\/div>\n

\n

\ud45c\uc900 \uc6a9\uc561\uc758 \uc900\ube44<\/h3>\n

 <\/p>\n

\ub8e8\ud2f4\uacfc \ud018\ub974\uc2dc\ud2b8\ub9b0\uc758 \ud45c\uc900 \uc6d0\uc561\uc740 \uac01\uac01 190.8\u03bcg\/ml \ubc0f 106.0\u03bcg\/ml\uc758 \ub18d\ub3c4\ub85c \uba54\ud0c4\uc62c\uc5d0\uc11c \uc81c\uc870\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ud53c\ud06c \uba74\uc801\uacfc \ud761\uad11\ub3c4\ub85c\ubd80\ud130 \uac01\uac01 \ub3c4\ucd9c\ub41c \uc120\ud615 \ucd5c\uc18c \uc81c\uacf1 \ud68c\uadc0 \ubc29\uc815\uc2dd\uc744 \uc0ac\uc6a9\ud558\uc5ec \ud018\ub974\uc2dc\ud2b8\ub9b0\uacfc TF\uc758 \ud45c\uc900 \uace1\uc120\uc744 \ubcf4\uc815\ud558\uace0, \ud45c\uc900 \uace1\uc120\uc5d0 \ub530\ub77c \uc2dc\ub8cc \ub0b4 \ud018\ub974\uc2dc\ud2b8\ub9b0\uacfc TF\uc758 \ub18d\ub3c4\ub97c \uacc4\uc0b0\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

 <\/p>\n<\/div>\n

\n

\uc801\uc808\ud55c \ucd94\ucd9c \uc870\uac74 \uc120\ud0dd<\/h3>\n

 <\/p>\n

RSM\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc5f0\uad6c\ub97c \uac1c\ubc1c\ud558\uae30 \uc804\uc5d0 \uad00\ub828 \ub3c5\ub9bd \ubcc0\uc218\ub97c \uc120\ud0dd\ud558\uace0 \uc2e4\ud5d8 \ubc94\uc704\ub97c \uacb0\uc815\ud558\uae30 \uc704\ud574 \uc77c\ub828\uc758 \uc608\ube44 \ud14c\uc2a4\ud2b8\ub97c \uc218\ud589\ud588\uc2b5\ub2c8\ub2e4. \uc608\ube44 \uc2e4\ud5d8\uc758 \uccab \ubc88\uc9f8 \ub2e8\uacc4\ub294 Herba Polygoni Capitati\uc758 \ucd94\ucd9c\uc5d0 \uc801\ud569\ud55c \ubc29\ubc95\uc744 \uc120\ud0dd\ud558\ub294 \uac83\uc774\uc5c8\uc2b5\ub2c8\ub2e4. \uc138 \uac00\uc9c0 \ub2e4\ub978 \uc811\uadfc\ubc95, \uc989 \uce68\uc6a9, \ud658\ub958 \ubc0f \ucd08\uc74c\ud30c \ucd94\ucd9c \ucd94\ucd9c\uc744 \ud14c\uc2a4\ud2b8\ud588\uc2b5\ub2c8\ub2e4. \uc608\ube44 \uc2e4\ud5d8\uc758 \ub450 \ubc88\uc9f8 \ub2e8\uacc4\ub294 Herba Polygoni Capitati\uc5d0 \uc801\ud569\ud55c \ucd94\ucd9c \uc6a9\ub9e4\ub97c \uc120\ud0dd\ud558\ub294 \uac83\uc774\uc5c8\uc2b5\ub2c8\ub2e4. 0-100%(\uc218\uc911 \uc5d0\ud0c4\uc62c \ub610\ub294 \uba54\ud0c4\uc62c) \ubc94\uc704\uc758 \ub2e4\uc591\ud55c \ucd94\ucd9c \uc6a9\ub9e4\ub97c \uc0ac\uc6a9\ud558\uc5ec \ucd5c\uc0c1\uc758 \uc6a9\ub9e4\ub97c \uacb0\uc815\ud588\uc2b5\ub2c8\ub2e4. \uc14b\uc9f8, \uc6a9\ub9e4-\uc7ac\ub8cc \ube44\uc728(6:1, 8:1, 10:1, 12:1, 14:1;\u00a0v\/m<\/em>) \ucd94\ucd9c\uc5d0 \ub300\ud55c \uc870\uc0ac\ub294 \uc5d0\ud0c4\uc62c:\ubb3c(70:30,\u00a0v\/v<\/em>)\uc744 \uc6a9\ub9e4\ub85c \uc0ac\uc6a9\ud558\uc5ec \uc2e4\uc628\uc5d0\uc11c 30\ubd84 \ub3d9\uc548 \ucd08\uc74c\ud30c \ucd94\ucd9c\uc744 \ucd94\ucd9c\ud588\uc2b5\ub2c8\ub2e4. \ub137\uc9f8, \ucd94\uac00 \uc870\uc0ac\ub97c \uc704\ud574 \uc801\uc808\ud55c \uc785\uc790 \ud06c\uae30\ub97c \uc120\ud0dd\ud588\uc2b5\ub2c8\ub2e4. \ub9c8\uc9c0\ub9c9\uc73c\ub85c \ucd94\ucd9c \uc2dc\uac04(10\ubd84, 20\ubd84, 30\ubd84, 40\ubd84, 50\ubd84, 60\ubd84)\ub3c4 \ud14c\uc2a4\ud2b8\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc774\ub7ec\ud55c \uacb0\uacfc\ub97c \ubc14\ud0d5\uc73c\ub85c \uc911\uc2ec\ud569\uc131\uc124\uacc4(CCD)\ub97c \uc704\ud55c \uac01 \uad00\ub828\ubcc0\uc218\uc758 3\uac1c \uc218\uc900(\ud558\uc704, \uc911\uac04, \uc0c1\uc704)\uc744 \uc120\uc815\ud558\uc5ec \ubc18\uc751\ud328\ud134\uc744 \ubd84\uc11d\ud558\uace0 \ubaa8\ud615\uc744 \uad6c\ucd95\ud558\uc600\ub2e4.<\/p>\n

 <\/p>\n<\/div>\n

\n

\ud1b5\uacc4 \ubd84\uc11d<\/h3>\n

 <\/p>\n

CCD \uc808\ucc28\uc5d0\uc11c \uc5bb\uc740 \uc2e4\ud5d8 \ub370\uc774\ud130\ub294 RSM\uc744 \uc0ac\uc6a9\ud558\uc5ec \ub2e4\uc74c\uacfc \uac19\uc740 2\ucc28 \ub2e4\ud56d\uc2dd \ubaa8\ub378(Eq. (1))\uacfc \uc5bb\uc740 \ud68c\uadc0 \uacc4\uc218\uc5d0 \ub9de\uac8c \ubd84\uc11d\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n

\"An<\/p>\n

\uc5b4\ub514 X1<\/sub>, \uc5d1\uc2a42<\/sub>,\u2026, \uc5d1\uc2a4\ucf00\uc774<\/sub>\u00a0\uc751\ub2f5 Y\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \uc778\ucf54\ub529\ub41c \ub3c5\ub9bd \ubcc0\uc218\uc785\ub2c8\ub2e4. \u03b20<\/sub>,\u03b2\ub098<\/sub>\u00a0(i = 1, 2,\u2026, k), \u03b2ii<\/sub>\u00a0(i = 1, 2,\u2026, k) \ubc0f \u03b2ij<\/sub>\u00a0(i = 1, 2,\u2026, k)\ub294 \uac01\uac01 \uc808\ud3b8, \uc120\ud615, 2\ucc28 \ubc0f \uc0c1\ud638 \uc791\uc6a9 \ud56d\uc5d0 \ub300\ud55c \ud68c\uadc0 \uacc4\uc218\uc785\ub2c8\ub2e4. k\ub294 \ubcc0\uc218\uc758 \uc218\uc785\ub2c8\ub2e4.<\/p>\n

\uc2e4\ud5d8 \ub370\uc774\ud130\uc758 \ud68c\uadc0 \ubc0f \uadf8\ub798\ud53d \ubd84\uc11d\uc5d0\ub294 Design Expert \ubc84\uc804 8.0.5b(STAT-EASE Inc.) \uc18c\ud504\ud2b8\uc6e8\uc5b4\uac00 \uc0ac\uc6a9\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ubaa8\ub378\uc758 \uc801\ud569\ub3c4 \ud488\uc9c8\uc740 \uacb0\uc815 \uacc4\uc218\ub97c \uc0ac\uc6a9\ud558\uc5ec \ud3c9\uac00\ub418\uc5c8\uc2b5\ub2c8\ub2e4(\uc544\ub974 \uc790\ud615<\/em>2<\/sup>) \ubc0f \ubd84\uc0b0 \ubd84\uc11d(ANOVA). \ubc18\uc751 \ud45c\uba74\uacfc \ub4f1\uace0\uc120 \ud50c\ub86f\uc740 \uc801\ud569 2\ucc28 \ub2e4\ud56d \ubc29\uc815\uc2dd\uc744 \uc0ac\uc6a9\ud558\uc5ec \uac1c\ubc1c\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n

 <\/p>\n<\/div>\n<\/div>\n

\n
\uc774\ub3d9 :<\/a><\/div>\n

\uacb0\uacfc \ubc0f \ud1a0\ub860<\/h2>\n

 <\/p>\n

\n

\uc2dc\uc2a4\ud15c \uc815\ubc00\ub3c4, HPLC \ub610\ub294 UV-Vis\uc758 \uc120\ud615\uc131<\/h3>\n

 <\/p>\n

\ucd94\ucd9c\ud6a8\uc728 \ud3c9\uac00\ub97c \uc704\ud55c \ub9c8\ucee4\ub85c Quercitrin\uacfc TF\ub97c \uc9c0\uc815\ud558\uc600\ub2e4. \ucc38\uc870 \ud45c\uc900\uacfc Herba Polygoni Capitati \ucd94\ucd9c\ubb3c\uc758 HPLC \ud504\ub85c\ud30c\uc77c\uc740 \ub2e4\uc74c\uacfc \uac19\uc2b5\ub2c8\ub2e4.\u00a0\uadf8\ub9bc 1<\/a>. \ud018\ub974\uc2dc\ud2b8\ub9b0 \uc218\uc900\uc5d0 \ub300\ud55c \ud53c\ud06c \uba74\uc801\uc758 \uac80\ub7c9\uc120\uc740 \ub2e4\uc74c\uacfc \uac19\uc2b5\ub2c8\ub2e4.\u00a0\uc640\uc774<\/em>\u00a0= 47.622\u00a0\uc5d1\uc2a4<\/em>\u00a0\u2212 0.033-1.06\u03bcg\uc758 \uc120\ud615 \ubc94\uc704\uc5d0\uc11c 0.2231(\uc544\ub974 \uc790\ud615<\/em>2<\/sup>\u00a0= 1.0000,\u00a0\uc640\uc774<\/em>\u00a0= \ud53c\ud06c \uba74\uc801 \ubc0f\u00a0\uc5d1\uc2a4<\/em>\u00a0= \ud018\ub974\uc2dc\ud2b8\ub9b0 \uc591). TF \uc591\uc5d0 \ub530\ub978 \ud761\uad11\ub3c4\uc758 \uac80\ub7c9\uc120\uc740 \ub2e4\uc74c\uacfc \uac19\ub2e4.\u00a0\uc640\uc774<\/em>\u00a0= 0.0029\u00a0\uc5d1\uc2a4<\/em>\u00a0\u2013 74.32-267.12 \u03bcg\uc758 \uc120\ud615 \ubc94\uc704\uc5d0\uc11c 0.0088(\uc544\ub974 \uc790\ud615<\/em>2<\/sup>\u00a0= 0.9996,\u00a0\uc640\uc774<\/em>\u00a0= \ud761\uad11\ub3c4 \ubc0f\u00a0\uc5d1\uc2a4<\/em>\u00a0= TF \uae08\uc561).<\/p>\n

\n
\"An<\/div>\n
\n
\uadf8\ub9bc 1<\/a><\/div>\n
\n

260nm\uc5d0\uc11c \uc778\uc99d\ub41c \ucc38\uc870 \ud654\ud569\ubb3c\uc778 \ud018\ub974\uc2dc\ud2b8\ub9b0(a)\uacfc Herba Polygoni Capitati(b) \ucd94\ucd9c\ubb3c\uc758 HPLC \ud06c\ub85c\ub9c8\ud1a0\uadf8\ub7a8<\/p>\n

 <\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\n

\ub9e4\uac1c\ubcc0\uc218 \uacb0\uc815 \ubc0f \uc218\uc900 \uc120\ud0dd<\/h3>\n
\n

 <\/p>\n

\ucd94\ucd9c \ubc29\ubc95\uc758 \ud6a8\uacfc<\/h4>\n

 <\/p>\n

\uce68\uc5f0, \ud658\ub958 \ubc0f \ucd08\uc74c\ud30c \ucc98\ub9ac \ucd94\ucd9c\uc744 \ud3ec\ud568\ud55c \uc138 \uac00\uc9c0 \ucd94\ucd9c \ubc29\ubc95\uc744 \ub2e4\uc74c \ub9e4\uac1c\ubcc0\uc218 \uac12\uc73c\ub85c \ud14c\uc2a4\ud2b8\ud588\uc2b5\ub2c8\ub2e4: \uc785\uc790 \ud06c\uae30, 10 \uba54\uc26c; \uc6a9\ub9e4-\uc7ac\ub8cc \ube44\uc728, 10:1(ml\/g); \ucd94\ucd9c \uae30\uac04, \ud658\ub958 \ubc0f \ucd08\uc74c\ud30c \ucd94\ucd9c \ucd94\ucd9c\uc5d0 30\ubd84, \uce68\uc5f0 \ucd94\ucd9c\uc5d0 12\uc2dc\uac04; \uc6a9\ub9e4 \uc870\uc131\ubb3c, 70% \uc218\uc131 \uc5d0\ud0c4\uc62c; \uc628\ub3c4, \uc2e4\ub0b4 \uc628\ub3c4. DM 1g\ub2f9 \ucd94\ucd9c\ub41c \ud018\ub974\uc2dc\ud2b8\ub9b0\uacfc TF\uc758 \uc591\uc740 \ub2e4\uc74c\uacfc \uac19\uc2b5\ub2c8\ub2e4.\u00a0\uadf8\ub9bc 2<\/a>. \uc2e4\ud5d8 \uacb0\uacfc\uc5d0 \ub300\ud55c ANOVA\ub294 \uc138 \uac00\uc9c0 \ucd94\ucd9c \ubc29\ubc95 \uac04\uc5d0 \uc720\uc758\ubbf8\ud55c \ucc28\uc774\ub97c \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4(\ud53c<\/em>\u00a0< 0.01). \ud55c\ud3b8, \ucd08\uc74c\ud30c \ucd94\ucd9c \ubc29\ubc95\uc740 \ud018\ub974\uc2dc\ud2b8\ub9b0\uacfc TF\uc758 \uc218\uc728\uc774 \uac00\uc7a5 \ub192\uc544 \ucd94\ucd9c \ubc29\ubc95\uc73c\ub85c \uc120\ud0dd\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n

\n
\"An<\/div>\n
\n
\uadf8\ub9bc 2<\/a><\/div>\n
\n

Herba Polygoni Capitati\uc5d0\uc11c \ud018\ub974\uc2dc\ud2b8\ub9b0(\uc67c\ucabd)\uacfc TF(\uc624\ub978\ucabd)\ub97c \ucd94\ucd9c\ud558\ub294 \ub2e4\uc591\ud55c \ubc29\ubc95\uc758 \ud6a8\uacfc<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\n

 <\/p>\n

\ucd94\ucd9c \uc6a9\ub9e4\uc758 \uc601\ud5a5<\/h4>\n

 <\/p>\n

\uc6a9\ub9e4\ub294 \ubd84\uc11d\ubb3c\uc9c8\uc758 \ud68c\uc218\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \ud575\uc2ec \uc694\uc18c\uc785\ub2c8\ub2e4. \ubcf8 \uc5f0\uad6c\uc5d0\uc11c\ub294 \ubb3c, \ub2e4\uc591\ud55c \ub18d\ub3c4\uc758 \uba54\ud0c4\uc62c \ubc0f \ub2e4\uc591\ud55c \ub18d\ub3c4\uc758 \uc5d0\ud0c4\uc62c\uc744 \ud14c\uc2a4\ud2b8\ud588\uc2b5\ub2c8\ub2e4. \uc5d0 \ud45c\uc2dc\ub41c \ubc14\uc640 \uac19\uc774\u00a0\uadf8\ub9bc 3<\/a>, 60% \uc218\uc131 \uc5d0\ud0c4\uc62c\uc758 \ucd94\ucd9c \ud6a8\uc728\uc774 \uac00\uc7a5 \ub192\uc558\ub2e4. \ub530\ub77c\uc11c \ucd94\uac00 RSM \uc870\uc0ac\ub97c \uc704\ud574 \uc6a9\ub9e4 \uc870\uc131\uc758 \ud558\uc704, \uc911\uac04 \ubc0f \uc0c1\uc704 \uc218\uc900\uc73c\ub85c 50%, 60% \ubc0f 70% \uc5d0\ud0c4\uc62c\uc744 \uc120\ud0dd\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

\n
\"An<\/div>\n
\n
\uadf8\ub9bc 3<\/a><\/div>\n
\n

Herba Polygoni Capitati\uc5d0\uc11c \ucd08\uc74c\ud30c\ub97c \uc774\uc6a9\ud55c \ucf00\ub974\uc2dc\ud2b8\ub9b0 \ubc0f TF \ucd94\ucd9c\uc5d0 \ub300\ud55c \uc6a9\ub9e4 \uc870\uc131\uc758 \uc601\ud5a5<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\n

 <\/p>\n

\uc6a9\ub9e4-\uc7ac\ub8cc \ube44\uc728<\/h4>\n

 <\/p>\n

\ucd94\ucd9c\uc5d0 \ub300\ud55c \uc6a9\ub9e4-\uc7ac\ub8cc \ube44\uc728\uc758 \uc601\ud5a5\uc740 5\uac00\uc9c0 \uac12(6:1, 8:1, 10:1, 12:1, 14:1;\u00a0v\/m<\/em>). \uc801\ud569\ud55c \uc6a9\ub9e4-\uc7ac\ub8cc \ube44\uc728 \uac12\uc740 \uaddc\uce59\uc5d0 \ub530\ub77c \uc120\ud0dd\ub429\ub2c8\ub2e4.29<\/a>] \uadf8 \uac12\uc740 \ub108\ubb34 \uc791\uac70\ub098(\uc0dd\ub9ac \ud65c\uc131 \ud654\ud569\ubb3c\uc744 \uc644\uc804\ud788 \ucd94\ucd9c\ud560 \uc218 \uc5c6\uc74c) \ub108\ubb34 \ub192\uc544\uc11c\ub294 \uc548 \ub429\ub2c8\ub2e4(\ucc98\ub9ac \ube44\uc6a9\uc774 \uac10\ub2f9\ud560 \uc218 \uc5c6\uc744 \uc815\ub3c4\ub85c \ub192\uc74c). \uc81c\uc2dc\ub41c \ubc14\uc640 \uac19\uc774\u00a0\uadf8\ub9bc 4<\/a>, \ud018\ub974\uc2dc\ud2b8\ub9b0\uacfc TF \uc218\uc728\uc758 \uc99d\uac00 \ucd94\uc138\uac00 \uad00\ucc30\ub418\uc5c8\uc73c\uba70 \ube44\uc728\uc774 \uc57d 10:1\uc77c \ub54c \uac00\uc7a5 \ub192\uc740 \uac12\uc5d0 \ub3c4\ub2ec\ud588\uc2b5\ub2c8\ub2e4. \uac00\ub2a5\ud55c \uc124\uba85\uc740 \uc6a9\ub9e4-\ubb3c\uc9c8 \ube44\uc728\uc758 \uc99d\uac00\uac00 \uc6a9\ub9e4\uc758 \uc138\ud3ec \ub0b4 \ud655\uc0b0\uc131\uc744 \uc99d\uac00\uc2dc\ud0a4\uace0 \uc138\ud3ec\ub85c\ubd80\ud130 \ud398\ub180\uc131 \ud654\ud569\ubb3c\uc758 \ud0c8\ucc29\uc744 \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\ub2e4\ub294 \uac83\uc785\ub2c8\ub2e4.30<\/a>] \ubcf8 \uc5f0\uad6c\uc5d0\uc11c\ub294 \ube44\uc728 \uac12\uc774 10:1\ubcf4\ub2e4 \ub192\uc744 \ub54c \ud018\ub974\uc2dc\ud2b8\ub9b0\uacfc TF \uc218\uc728\uc774 \uc57d\uac04 \uac10\uc18c\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub294\ub370, \uc774\ub294 \uc81c\ud488 \uc218\uc9d1\uc774\ub098 \uacf5\uc815 \uc6b4\uc601 \uc2dc \uc190\uc2e4\uc774 \ub354 \ud06c\uae30 \ub54c\ubb38\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c \ud6c4\uc18d \uc5f0\uad6c\uc5d0\uc11c\ub294 \uc6a9\ub9e4-\uc7ac\ub8cc \ube44\uc728\uc744 RSM\uc758 \uc911\uac04 \uc218\uc900\uc73c\ub85c 10:1\ub85c \uc124\uc815\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

\n
\"An<\/div>\n
\n
\uadf8\ub9bc 4<\/a><\/div>\n
\n

\ud018\ub974\uc2dc\ud2b8\ub9b0 \ubc0f TF \uc218\uc728\uc5d0 \ub300\ud55c \uc6a9\ub9e4-\uc7ac\ub8cc \ube44\uc728\uc758 \uc601\ud5a5<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\n

 <\/p>\n

\uc785\uc790 \ud06c\uae30\uc758 \uc601\ud5a5<\/h4>\n

 <\/p>\n

\uc785\uc790 \ud06c\uae30\ub294 \uace0\ub824\ud574\uc57c \ud560 \ub610 \ub2e4\ub978 \uc911\uc694\ud55c \ubcc0\uc218\uc785\ub2c8\ub2e4. \uc77c\ubc18\uc801\uc73c\ub85c \ucd94\ucd9c\ud6a8\uc728\uc740 \uc785\uc790\ud06c\uae30\uac00 \uc791\uc744\uc218\ub85d \uc99d\uac00\ud55c\ub2e4.\uadf8\ub9bc 5<\/a>]. \ubcf8 \uc5f0\uad6c\uc5d0\uc11c\ub294 \uc785\uc790 \ud06c\uae30\ub97c \uc9c1\uacbd 0.45~0.9mm\ub85c \uc124\uc815\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

\n
\"An<\/div>\n
\n
\uadf8\ub9bc 5<\/a><\/div>\n
\n

\ud018\ub974\uc2dc\ud2b8\ub9b0 \ubc0f TF\uc758 \uc218\uc728\uc5d0 \ub300\ud55c \uc785\uc790 \ud06c\uae30\uc758 \uc601\ud5a5<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\n

 <\/p>\n

\ucd94\ucd9c \uc2dc\uac04\uc758 \uc601\ud5a5<\/h4>\n

 <\/p>\n

\uc801\uc808\ud55c \ucd94\ucd9c \uc2dc\uac04\uc744 \uc120\ud0dd\ud558\ub294 \uac83\uc774 \uc608\ube44 \uc5f0\uad6c\uc758 \ub9c8\uc9c0\ub9c9 \ub2e8\uacc4\uc600\uc2b5\ub2c8\ub2e4. \ucd5c\uc801\uc758 \uac12\uc744 \uc870\uc0ac\ud558\uae30 \uc704\ud574 10, 20, 30, 40, 50 \ubc0f 60\ubd84\uc758 \ub2e4\uc591\ud55c \ucd94\ucd9c \uae38\uc774\ub97c \ud14c\uc2a4\ud2b8\ud588\uc2b5\ub2c8\ub2e4. \uadf8 \uacb0\uacfc, \ucd94\ucd9c\uc2dc\uac04\uc774 10\ubd84\uc5d0\uc11c 50\ubd84\uc73c\ub85c \uae38\uc5b4\uc9c8\uc218\ub85d \ud018\ub974\uc2dc\ud2b8\ub9b0\uacfc TF\uc758 \uc218\uc728\uc774 \uc99d\uac00\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4.\uadf8\ub9bc 6<\/a>]. 50\ubd84 \uc218\uc900\uc5d0\uc11c \ud018\ub974\uc2dc\ud2b8\ub9b0\uacfc TF \uc218\uc728\uc774 \uac00\uc7a5 \ub192\uc740 \uc218\uc900\uc5d0 \ub3c4\ub2ec\ud588\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c \ucd94\ucd9c \uc2dc\uac04\uc758 \ud558\uc704, \uc911\uac04, \uc0c1\uc704 \uc218\uc900\uc73c\ub85c 40\ubd84, 50\ubd84, 60\ubd84\uc744 \uc120\ud0dd\ud558\uc600\ub2e4.<\/p>\n

\n
\"An<\/div>\n
\n
\uadf8\ub9bc 6<\/a><\/div>\n
\n

\ucd94\ucd9c \uc2dc\uac04\uc774 \ud018\ub974\uc2dc\ud2b8\ub9b0 \ubc0f TF \uc218\uc728\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5<\/p>\n

 <\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\n

RSM\uc744 \ud1b5\ud55c \ucd94\ucd9c \ub9e4\uac1c\ubcc0\uc218 \ucd5c\uc801\ud654<\/h3>\n
\n

 <\/p>\n

\ub2e4\uc911\uc120\ud615\ud68c\uadc0 \uacb0\uacfc \ubc0f \uc801\ud569\ubaa8\ub378\uc758 \uc801\ud569\uc131 \ubd84\uc11d<\/h4>\n

 <\/p>\n

20\uac1c\uc758 \uc2e4\ud5d8 \uc2e4\ud589\uc73c\ub85c \uad6c\uc131\ub41c 3\uc694\uc18c \ubc0f 3\ub2e8\uacc4 \ud68c\uc804 \uac00\ub2a5 CCD\uac00 \uc911\uc2ec\uc810\uc5d0\uc11c 6\ubc88\uc758 \ubc18\ubcf5\uc2e4\ud5d8\uc73c\ub85c \uc0ac\uc6a9\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc2e4\ud5d8 \uc21c\uc11c\ub97c \ubb34\uc791\uc704\ub85c \uc9c0\uc815\ud558\uc5ec \uc124\uba85\ub418\uc9c0 \uc54a\ub294 \ubcc0\ub3d9\uc131\uc758 \uc601\ud5a5\uc744 \ucd5c\uc18c\ud654\ud588\uc2b5\ub2c8\ub2e4. \ub3c5\ub9bd \ubcc0\uc218\ub294 \uc6a9\ub9e4 \uc870\uc131(X1<\/sub>, %,\u00a0v\/v<\/em>, \uc5d0\ud0c4\uc62c\/\ubb3c), \uc6a9\ub9e4-\uc7ac\ub8cc \ube44\uc728(X2<\/sub>, ml\/g) \ubc0f \ucd94\ucd9c \uc2dc\uac04(X3<\/sub>, min) \ud018\ub974\uc2dc\ud2b8\ub9b0\uacfc TF \uc218\uc728\uc744 \uc9c0\ud45c\ub85c \uc0ac\uc6a9\ud569\ub2c8\ub2e4. \uace0\uc815\ub41c \uc785\uc790 \ud06c\uae30(0.45-0.9mm)\uac00 \uc120\ud0dd\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ubaa8\ub4e0 \uc2e4\ud589\uc758 \ud018\ub974\uc2dc\ud2b8\ub9b0 \ubc0f TF \uc218\uc728\uc740 \ub2e4\uc74c\uacfc \uac19\uc2b5\ub2c8\ub2e4.\u00a01 \ubc88 \ud14c\uc774\ube14<\/a>. \uc774\ub7ec\ud55c \uacb0\uacfc\ub97c \ubc14\ud0d5\uc73c\ub85c 2\ucc28 \ub2e4\ud56d\uc2dd \ubaa8\ub378(Eq. (1))\uc744 \uc774\uc6a9\ud55c \ub2e4\uc911 \uc120\ud615 \ud68c\uadc0\ub97c \uc218\ud589\ud558\uc600\ub2e4.<\/p>\n

 <\/p>\n

\n

1 \ubc88 \ud14c\uc774\ube14<\/h3>\n
\n

\ub3c5\ub9bd \ubcc0\uc218(X)\uc758 \uc6d0\ub798 \ud615\uc2dd\uacfc \ucf54\ub4dc\ud654\ub41c \ud615\uc2dd\uc73c\ub85c \ud68c\uc804 \uac00\ub2a5\ud55c \uc911\uc2ec \ud569\uc131 \uc124\uacc4 \uc124\uc8151<\/sub>, \uc5d1\uc2a42<\/sub>, \uc5d1\uc2a43<\/sub>) \ubc0f \ubc18\uc751 \ubcc0\uc218\uc778 \ud018\ub974\uc2dc\ud2b8\ub9b0\uacfc TF\uc5d0 \ub300\ud55c \uc2e4\ud5d8 \uacb0\uacfc<\/p>\n<\/div>\n

\"An<\/div>\n<\/div>\n

\ub3c5\ub9bd \ubcc0\uc218\uc758 ANOVA\ub294 \ub2e4\uc74c\uacfc \uac19\uc2b5\ub2c8\ub2e4.\u00a0\ud45c 2<\/a>\u00a0\uc774\ub294 \uc774 \uc138 \uac00\uc9c0 \ub3c5\ub9bd \ubcc0\uc218\uac00 \ubaa8\ub450 \ucd94\ucd9c \ud6a8\uc728\uc5d0 \ud070 \uc601\ud5a5\uc744 \ubbf8\uce5c\ub2e4\ub294 \uac83\uc744 \ub098\ud0c0\ub0c5\ub2c8\ub2e4(\ud53c<\/em>\u00a0< 0.05). \ub2e4\uc911 \uacb0\uc815\uc758 \ud574\ub2f9 \uacc4\uc218\ub97c \uc0ac\uc6a9\ud558\uc5ec \ud53c\ud305\ub41c 2\ucc28 \ubaa8\ub378\uc758 \ud68c\uadc0 \ub9e4\uac1c\ubcc0\uc218(\uc544\ub974 \uc790\ud615<\/em>2<\/sup>)\uc5d0 \ud45c\uc2dc\ub418\uc5c8\uc2b5\ub2c8\ub2e4.\u00a0\ud45c 3<\/a>. \uc88b\uc740 \ud53c\ud305\uc774 \ub2ec\uc131\ub418\uc5c8\uc73c\uba70 \uc751\ub2f5\uc758 \uac00\ubcc0\uc131\uc774 \ubaa8\ub378\uc5d0 \uc758\ud574 \uc124\uba85\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ub192\uc740\u00a0\uc544\ub974 \uc790\ud615<\/em>2<\/sup>\u00a0\ud018\ub974\uc2dc\ud2b8\ub9b0\uacfc TF\uc5d0 \ub300\ud574 \uac01\uac01 0.94\uc640 0.96\uc758 \uac12\uc740 \uc2e4\ud5d8 \ub370\uc774\ud130\uac00 \ubaa8\ub378\uc5d0 \uc758\ud574 \uc608\uce21\ub41c \ub370\uc774\ud130\uc640\uc758 \ud638\ud658\uc131\uc744 \ud655\uc778\ud588\uc74c\uc744 \uc758\ubbf8\ud569\ub2c8\ub2e4. \ubcc0\ub3d9 \uacc4\uc218\uc758 \ub0ae\uc740 \uac12(\ud018\ub974\uc2dc\ud2b8\ub9b0\uc758 \uacbd\uc6b0 1.92%, TF\uc758 \uacbd\uc6b0 3.28%)\uc740 \uc801\ud569 \ubaa8\ub378\uc5d0\uc11c \uc5bb\uc740 \uacb0\uacfc\uac00 \uc2e0\ub8b0\ud560 \uc218 \uc788\uc74c\uc744 \ub098\ud0c0\ub0c5\ub2c8\ub2e4. \uc870\uc815\ub41c \uacb0\uc815\uacc4\uc218(\uc544\ub974 \uc790\ud615<\/em>2<\/sup>\u00a0Adj.) \uac12\uc740 \ud3ec\ud568\ub41c \ubaa8\ub4e0 *\uc720\uc758\uc801\uc778 \uc6a9\uc5b4\uc640 \ub192\uc740 \uac12\uc744 \uc0ac\uc6a9\ud558\uc5ec \ud45c\ud604\uc2dd\uc744 \uc7ac\uad6c\uc131\ud569\ub2c8\ub2e4.\u00a0\uc544\ub974 \uc790\ud615<\/em>2<\/sup>\u00a0\uc870\uc815 (\uc544\ub974 \uc790\ud615<\/em>2<\/sup>\u00a0\uc870\uc815 \uac01\uac01 87%, 92%\uc640 \uac19\uc74c)\ub294 \ubaa8\ub378\uc758 \uc911\uc694\uc131\uc744 \ub4b7\ubc1b\uce68\ud569\ub2c8\ub2e4.<\/p>\n

 <\/p>\n

\n

\ud45c 2<\/h3>\n
\n

\ubc18\uc751 \ud45c\uba74 2\ucc28 \ubaa8\ub378\uc758 \ubd84\uc0b0 \ubd84\uc11d<\/p>\n<\/div>\n

\"An<\/div>\n
<\/div>\n<\/div>\n
\n

<\/h3>\n

\ud45c 3<\/h3>\n
\n

\ubc18\uc751 \ubcc0\uc218\uc778 \ud018\ub974\uc2dc\ud2b8\ub9b0\uacfc TF\uc5d0 \ub300\ud55c \uc608\uce21\ub41c 2\ucc28 \ubaa8\ub378\uc758 \ud68c\uadc0 \uacc4\uc218<\/p>\n<\/div>\n

\"An<\/div>\n<\/div>\n

\uc801\ud569\uc131 \uacb0\uc5ec \ud14c\uc2a4\ud2b8\ub294 \ubaa8\ub378 \uc801\ud569\ub3c4\uc758 \uc801\uc808\uc131\uc744 \ud655\uc778\ud558\ub294 \ub370 \uc0ac\uc6a9\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc801\ud569\uc131 \uacb0\uc5ec \ud14c\uc2a4\ud2b8\uc5d0 \ub300\ud55c ANOVA\ub294 \ud018\ub974\uc2dc\ud2b8\ub9b0 \ubc0f TF \uc218\uc728\uacfc \uad00\ub828\ud558\uc5ec \uc720\uc758\ubbf8\ud558\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4(\ud53c<\/em>\u00a0> 0.05), \uc774\ub294 \ubaa8\ub378\uc774 \uc2e4\ud5d8 \ub370\uc774\ud130\uc5d0 \uc801\uc808\ud558\uac8c \uc801\ud569\ud560 \uc218 \uc788\uc74c\uc744 \ub098\ud0c0\ub0c5\ub2c8\ub2e4.\ud45c 4<\/a>].<\/p>\n

 <\/p>\n

\n

\ud45c 4<\/h3>\n
\n

\ud018\ub974\uc2dc\ud2b8\ub9b0 \ubc0f TF\uc5d0 \ub300\ud55c \uc801\ud569\uc131 \ud14c\uc2a4\ud2b8 \ubd80\uc871\uc5d0 \ub300\ud55c \ubd84\uc0b0 \ubd84\uc11d<\/p>\n<\/div>\n

\"An<\/div>\n<\/div>\n<\/div>\n
\n

 <\/p>\n

\ubc18\uc751 \ud45c\uba74 \ubd84\uc11d<\/h4>\n

 <\/p>\n

\ubd80\ud130; \ubaa8\ub378\uc774 \uc88b\uc740 \ud53c\ud305\uc744 \ubcf4\uc5ec\uc8fc\uace0, \uc751\ub2f5 \uac12\uc740 \ud68c\uadc0 \ubc29\uc815\uc2dd\uc73c\ub85c \ucda9\ubd84\ud788 \uc124\uba85\ub429\ub2c8\ub2e4. \ub3c5\ub9bd \ubcc0\uc218\uc758 \uc0c1\ud638 \uc791\uc6a9\uc744 \ubcf4\uc5ec\uc8fc\uace0 \ucd5c\ub300 \ubc18\uc751\uc5d0 \ub300\ud55c \uac01 \ub3c5\ub9bd \ubcc0\uc218\uc758 \ucd5c\uc801 \uac12\uc744 \uacb0\uc815\ud558\uae30 \uc704\ud574 \ubc18\uc751 \ud45c\uba74 \uace1\uc120\uc744 \ud50c\ub86f\ud588\uc2b5\ub2c8\ub2e4. \ub3c5\ub9bd\ubcc0\uc218\uc640 \uc885\uc18d\ubcc0\uc218 \uc0ac\uc774\uc758 \uad00\uacc4\ub294 3\ucc28\uc6d0(3D) \ubc18\uc751 \ud45c\uba74 \ud50c\ub86f\uacfc 2\ucc28\uc6d0(2D) \ub4f1\uace0\uc120 \ud50c\ub86f\uc73c\ub85c \uc124\uba85\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ud68c\uadc0\uc2dd\uc744 \uadf8\ub798\ud53d\uc73c\ub85c \ud45c\ud604\ud55c 3\ucc28\uc6d0 \ubc18\uc751\ud45c\uba74\uacfc 2\ucc28\uc6d0 \ub4f1\uace0\uc120\ub3c4\ub97c \uc81c\uacf5\ud558\uc600\ub2e4.\u00a0\u200b[\uadf8\ub9bc7<\/span>7<\/a>\u00a0\uadf8\ub9ac\uace0\u00a0\u200b\uadf8\ub9ac\uace08].<\/span>8<\/a>]. \uac01 \ub4f1\uace0\uc120 \uace1\uc120\uc740 \ub2e4\ub978 \ub3c5\ub9bd \ubcc0\uc218\ub97c \uace0\uc815\uc810\uc5d0 \uc720\uc9c0\ud558\uba74\uc11c \ub450 \ub3c5\ub9bd \ubcc0\uc218\uc758 \ubb34\ud55c\ud55c \uc870\ud569 \uc218\ub97c \ub098\ud0c0\ub0c5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ubc29\uc2dd\uc73c\ub85c 3D \uc751\ub2f5 \ud45c\uba74\uc744 \uc27d\uac8c \uc2dc\uac01\ud654\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.\u00a0\uadf8\ub9bc 7a<\/a>\u00a0\uc740 \uc6a9\ub9e4 \uc870\uc131\uacfc \uc6a9\ub9e4-\ubb3c\uc9c8 \ube44\uc728\uc5d0 \ub300\ud55c \ubaa8\ub378\uc744 \ud1b5\ud574 \uac1c\ubc1c\ub41c 3\ucc28\uc6d0 \ubc18\uc751 \ud45c\uba74 \ud568\uc218\ub97c \ubcf4\uc5ec\uc90d\ub2c8\ub2e4. \uc6a9\ub9e4 \uc870\uc131\uc740 \ubc18\uc751\uc5d0 \ub300\ud55c 2\ucc28 \ud6a8\uacfc\ub97c \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4. \ud018\ub974\uc2dc\ud2b8\ub9b0\uc758 \ud568\ub7c9\uc740 65% \uc5d0\ud0c4\uc62c\uc744 \uc0ac\uc6a9\ud560 \ub54c \uac00\uc7a5 \ub192\uc740 \uac12\uc5d0 \ub3c4\ub2ec\ud569\ub2c8\ub2e4. \ub9c8\ucc2c\uac00\uc9c0\ub85c, \uc6a9\ub9e4-\uc7ac\ub8cc \ube44\uc728\uc740 \ub3d9\uc2dc\uc5d0 \ud018\ub974\uc2dc\ud2b8\ub9b0\uc5d0 \ub300\ud55c 2\ucc28 \ud6a8\uacfc\ub97c \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4. TF\uc5d0 \ub300\ud55c \uc6a9\ub9e4 \uc870\uc131 \ubc0f \uc6a9\ub9e4-\uc7ac\ub8cc \ube44\uc728\uc758 \uc601\ud5a5 \uacb0\uacfc\ub294 \ub2e4\uc74c\uacfc \uac19\uc2b5\ub2c8\ub2e4.\u00a0\uadf8\ub9bc 8a<\/a>. \uc6a9\ub9e4 \uc870\uc131\uc740 60%\uc640 70% \uc5d0\ud0c4\uc62c \uc0ac\uc774\uc5d0\uc11c \ucd5c\ub300\uac12\uc744 \uc0b0\ucd9c\ud558\ub294 \ubc18\uc751\uc5d0 \ub300\ud574 2\ucc28 \ud6a8\uacfc\ub97c \ub098\ud0c0\ub0c8\uc2b5\ub2c8\ub2e4. \ub9c8\ucc2c\uac00\uc9c0\ub85c, \uc6a9\ub9e4-\ubb3c\uc9c8 \ube44\uc728\uc774 \uc99d\uac00\ud568\uc5d0 \ub530\ub77c \uc6a9\ub9e4 \uc870\uc131\uc774 \uace0\uc815\ub418\uba74 TF\ub294 \uc810\ucc28 \uc99d\uac00\ud558\uc5ec \uc6a9\ub9e4-\ubb3c\uc9c8 \ube44\uc728\uc774 \uc57d 10:1\uc77c \ub54c \uac00\uc7a5 \ub192\uc740 \uac12\uc5d0 \ub3c4\ub2ec\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

\n
\"An<\/div>\n
\n
\uadf8\ub9bc 7<\/a><\/div>\n
\n

\uc6a9\ub9e4 \uc870\uc131(X1), \uc6a9\ub9e4 \ubb3c\uc9c8 \ube44\uc728(X2) \ubc0f \ucd94\ucd9c \uc2dc\uac04(X3)\uc774 \ud018\ub974\uc2dc\ud2b8\ub9b0 \uc218\uc728\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \ubcf4\uc5ec\uc8fc\ub294 \ubc18\uc751 \ud45c\uba74 \ud50c\ub86f(a, c \ubc0f e) \ubc0f \ub4f1\uace0\uc120 \ud50c\ub86f(b, d \ubc0f f)<\/p>\n<\/div>\n<\/div>\n<\/div>\n

\n
\"An<\/div>\n
\n
\uadf8\ub9bc 8<\/a><\/div>\n
<\/div>\n
\n

TF \uc218\uc728\uc5d0 \ub300\ud55c \uc6a9\ub9e4 \uc870\uc131(X1), \uc6a9\ub9e4 \uc7ac\ub8cc \ube44\uc728(X2) \ubc0f \ucd94\ucd9c \uc2dc\uac04(X3)\uc758 \uc601\ud5a5\uc744 \ubcf4\uc5ec\uc8fc\ub294 \ubc18\uc751 \ud45c\uba74 \ud50c\ub86f(a, c \ubc0f e) \ubc0f \ub4f1\uace0\uc120 \ud50c\ub86f(b, d \ubc0f f)<\/p>\n<\/div>\n<\/div>\n<\/div>\n

\ud018\ub974\uc2dc\ud2b8\ub9b0 \ubc0f TF \uc218\uc728\uc758 \ubc18\uc751 \uac12\uc5d0 \ub300\ud55c \ub3c5\ub9bd\ubcc0\uc218 \uc6a9\ub9e4 \uc870\uc131 \ubc0f \ucd94\ucd9c \uc2dc\uac04\uc758 \ud6a8\uacfc\uac00 \uadf8\ub9bc\uc5d0 \ud45c\uc2dc\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4.\u00a0\u200b\uadf8\ub9bc7c,<\/span>7c<\/a>,\u00a0\u200b,7\uc77c,<\/span>7\uc77c<\/a>,\u00a0\u200b,8c,<\/span>8c<\/a>,\u00a0\u200b,8d,<\/span>8\uc77c<\/a>, \uac01\uac01. \ub450 \ub3c5\ub9bd\ubcc0\uc218 \uc0ac\uc774\uc758 \uc0c1\ud638\uc791\uc6a9 \uad00\uacc4\ub294 \ub2e4\ub978 \ub3c5\ub9bd\ubcc0\uc218\uc778 \uc6a9\ub9e4-\ubb3c\uc9c8 \ube44\uc728\uc744 \uc815\uc9c0\uc810\uc5d0\uc11c \uc77c\uc815\ud558\uac8c \uc720\uc9c0\ud558\uc5ec \uc0dd\uc131\ub41c \ub4f1\uace0\uc120 \ud50c\ub86f\uc744 \uc0b4\ud3b4\ubcf4\uba74 \uc27d\uac8c \uc774\ud574\ud560 \uc218 \uc788\ub2e4.\u00a0\u200b[\uadf8\ub9bc7d<\/span>7\uc77c<\/a>\u00a0\uadf8\ub9ac\uace0\u00a0\u200b\uadf8\ub9ac\uace0 8d].<\/span>8\uc77c<\/a>]. \uc6a9\ub9e4 \uc870\uc131 \ubc0f \ucd94\ucd9c \uc2dc\uac04\uc774 \uc99d\uac00\ud560\uc218\ub85d \ud018\ub974\uc2dc\ud2b8\ub9b0\uacfc TF\uc758 \uc218\uc728\uc740 \uc720\uc758\ud558\uac8c \uc99d\uac00\ud558\uc600\ub2e4. \uadf8\ub7ec\ub098 \ub3c5\ub9bd \ubcc0\uc218\uac00 \ud2b9\uc815 \uac12\uc744 \ucd08\uacfc\ud558\uba74 \ud018\ub974\uc2dc\ud2b8\ub9b0\uacfc TF \uc218\uc728\uc774 \ub354 \uc774\uc0c1 \uc99d\uac00\ud558\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \uc6a9\ub9e4 \uc870\uc131\uacfc \ucd94\ucd9c \uc2dc\uac04\uc758 \uc0c1\ud638\uc791\uc6a9\uc740 \ud018\ub974\uc2dc\ud2b8\ub9b0 \uc218\uc728\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \ub370 \ud1b5\uacc4\uc801\uc73c\ub85c \uc720\uc758\ud558\uc9c0 \uc54a\uc558\uc9c0\ub9cc,\ud53c<\/em>\u00a0< 0.01) TF \ucd94\ucd9c\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5.<\/p>\n

\ud53c\uaddc\uc5b4\u00a0\u200b\uadf8\ub9bc7e<\/span>7e<\/a>\u00a0\uadf8\ub9ac\uace0\u00a0\u200b\uadf8\ub9ac\uace08e<\/span>8e<\/a>\u00a0\ud018\ub974\uc2dc\ud2b8\ub9b0\uacfc TF\uc758 \uc218\uc728\uc5d0 \ub300\ud55c \uc6a9\ub9e4-\uc7ac\ub8cc \ube44\uc728\uacfc \ucd94\ucd9c \uc2dc\uac04\uc758 \uc601\ud5a5\uc744 \uc785\uc99d\ud588\uc2b5\ub2c8\ub2e4. \ucd94\ucd9c \uc2dc\uac04\uacfc \uc6a9\ub9e4-\ubb3c\uc9c8 \ube44\uc728\uc774 \uc99d\uac00\ud568\uc5d0 \ub530\ub77c \ud018\ub974\uc2dc\ud2b8\ub9b0\uacfc TF\uc758 \uc218\uc728\uc774 \uc99d\uac00\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub294\ub370, \uc774\ub294 \ud018\ub974\uc2dc\ud2b8\ub9b0\uacfc TF\uc758 \ucd94\ucd9c \uc218\uc728\uc774 \ucd94\ucd9c \uc2dc\uac04\uacfc \uc6a9\ub9e4-\ubb3c\uc9c8\uc758 \ube44\uc728\uc5d0 \ube44\ub840\ud568\uc744 \uc758\ubbf8\ud55c\ub2e4. Herba Polygoni Capitati\ub85c\ubd80\ud130 \ud018\ub974\uc2dc\ud2b8\ub9b0\uacfc TF \ucd94\ucd9c\uc5d0 \ub300\ud55c \ub450 \ub3c5\ub9bd\ubcc0\uc218\uc758 \uc0c1\ud638\uc791\uc6a9\uc740 \ud1b5\uacc4\uc801\uc73c\ub85c \uc720\uc758\ud558\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4.<\/p>\n

 <\/p>\n<\/div>\n<\/div>\n

\n

\uac80\uc99d \uc2e4\ud5d8<\/h3>\n

 <\/p>\n

\ubaa8\ud615\uc758 \uc608\uce21\ub825\uc744 \uac80\uc99d\ud558\uae30 \uc704\ud574 RSM\uc758 \ub2a5\uc120 \ubd84\uc11d\uc744 \ud1b5\ud574 \ub3c4\ucd9c\ub41c \ucd5c\uc801\ud654 \uc870\uac74\uc5d0\uc11c \ucd5c\uc801 \ubc18\uc751\ubcc0\uc218\ub97c \uac80\uc815\ud558\uc600\ub2e4. \uadf8 \uacb0\uacfc, \uad00\uce21\uac12\uc740 \ubaa8\ub378 \uc608\uce21\uac12\uc758 95% \uc2e0\ub8b0\uad6c\uac04 \ub0b4\uc5d0\uc11c \ub9cc\uc871\uc2a4\ub7fd\uac8c \ub2ec\uc131\ub420 \uc218 \uc788\uc5c8\ub2e4[\ud45c 5<\/a>].<\/p>\n

 <\/p>\n

\n

\ud45c 5<\/h3>\n
\n

\ubc18\uc751\ubcc0\uc218\uc778 \ud018\ub974\uc2dc\ud2b8\ub9b0\uacfc TF\uc5d0 \ub300\ud55c \uc608\uce21\uac12\uacfc \uad00\uce21\uac12\uc758 \ube44\uad50<\/p>\n<\/div>\n

\"An<\/div>\n<\/div>\n<\/div>\n<\/div>\n
\n
<\/div>\n
\uc774\ub3d9 :<\/a><\/div>\n

\uacb0\ub860<\/h2>\n

 <\/p>\n

CCD\uc640 \uacb0\ud569\ub41c \ud55c \ubc88\uc5d0 \ud55c \uac00\uc9c0 \uc694\uc18c \uc811\uadfc \ubc29\uc2dd\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc6a9\ub9e4 \uc870\uc131, \uc6a9\ub9e4-\uc7ac\ub8cc \ube44\uc728 \ubc0f \ucd94\ucd9c \uc2dc\uac04\uc744 \ud3ec\ud568\ud55c \ucd08\uc74c\ud30c \ubcf4\uc870 \ucd94\ucd9c \ub9e4\uac1c\ubcc0\uc218\uac00 Herba Polygoni Capitati\uc5d0\uc11c \ud018\ub974\uc2dc\ud2b8\ub9b0 \ubc0f TF\ub97c \ucd94\ucd9c\ud558\uae30 \uc704\ud574 \ucd5c\uc801\ud654\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uacb0\uacfc\ub294 2\ucc28 \ub2e4\ud56d\uc2dd \ubaa8\ub378\uc774 \ucd94\ucd9c \ub370\uc774\ud130\uc5d0 \ub300\ud574 \ub9cc\uc871\uc2a4\ub7ec\uc6b4 \uc124\uba85\uc744 \uc81c\uacf5\ud55c\ub2e4\ub294 \uac83\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4. \ucd5c\uc801\ud654\ub41c \uc870\uac74\uc740 \ub2e4\uc74c\uacfc \uac19\uc2b5\ub2c8\ub2e4: \ucd94\ucd9c \ubc29\ubc95, \ucd08\uc74c\ud30c \ucd94\ucd9c; \uc6a9\ub9e4\uc778 \uacbd\uc6b0 65% \uc218\uc131 \uc5d0\ud0c4\uc62c\ub85c \ub9c8\ubb34\ub9ac\ud558\ub294 \uac83\uc774 \uc88b\uc2b5\ub2c8\ub2e4. \uc785\uc790 \ud06c\uae30, 0.45-0.9mm; \uc6a9\ub9e4-\uc7ac\ub8cc \ube44\uc728\uc740 10:1\ub85c \ubc18\uc62c\ub9bc\ub429\ub2c8\ub2e4. \ucd94\ucd9c \uc2dc\uac04\uc740 54\ubd84\uc73c\ub85c \ubc18\uc62c\ub9bc\ub429\ub2c8\ub2e4. \uc774 \uc5f0\uad6c\ub294 Herba Polygoni Capitati\uc758 \uc0b0\uc5c5 \ucd94\ucd9c \ud504\ub85c\uc138\uc2a4\uc5d0 \ub300\ud55c \uae30\ubcf8 \uc815\ubcf4\uc640 \uadc0\uc911\ud55c \ud1b5\ucc30\ub825\uc744 \uc81c\uacf5\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

 <\/p>\n<\/div>\n

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\uc774\ub3d9 :<\/a><\/div>\n

\uac10\uc0ac\uc758 \ub9d0<\/h2>\n

 <\/p>\n

\n

\uc800\uc790\ub4e4\uc740 \uad6c\uc774\uc800\uc6b0\uc131 \uc8fc\uc694 \uacfc\ud559 \uae30\uc220 \ud2b9\ubcc4 \ud504\ub85c\uadf8\ub7a8(2011-6019-02), \uad6c\uc774\uc800\uc6b0\uc131 \uc758\uc57d\ud488 \ubd84\uc11d \uacfc\ud559 \uae30\uc220 \ud601\uc2e0 \uc778\uc7ac \ud300 \ud504\ub85c\uadf8\ub7a8(No. 2011 6019-02)\uc758 \uc6d0\ub8cc \ubc0f \uc7ac\uc815 \uc9c0\uc6d0\uc744 \uc81c\uacf5\ud55c Guizhou Warmen Pharmaceutical Corporation\uc5d0 \uac10\uc0ac\ub4dc\ub9bd\ub2c8\ub2e4. . 2011 4008), \ud55c\uc758\ud559 \ud604\ub300\ud654\uc5d0 \uad00\ud55c \uacfc\ud559 \uae30\uc220 \uc0b0\uc5c5 \uc5f0\uad6c \ubc0f \uac1c\ubc1c\uc5d0 \uad00\ud55c \uad6c\uc774\uc800\uc6b0\uc131 \ud2b9\ubcc4 \ud504\ub85c\uadf8\ub7a8(No. ZY 2011 3013), \ud55c\uc758\ud559 \ubc0f \ubbfc\uc871 \uc758\ud559 \ud45c\uc900\ud654\uc758 \ud2b9\uc131 \ud575\uc2ec \uc5f0\uad6c\uc18c \ubc0f \uad6c\uc774\uc800\uc6b0 \ud2b9\uc131 \ud575\uc2ec \uc5f0\uad6c\uc18c \uc9c0\ubc29 \uad50\uc721\ubd80. (\ubc88\ud638 KY 2012 005).<\/p>\n

 <\/p>\n<\/div>\n<\/div>\n

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\uc774\ub3d9 :<\/a><\/div>\n

\uac01\uc8fc<\/h2>\n
\n

\n

\uc9c0\uc6d0 \ucd9c\ucc98:<\/strong>\u00a0\ubb34<\/p>\n

\uc774\ud574 \uc0c1\ucda9:<\/strong>\u00a0\uc120\uc5b8\ub41c \ubc14\uac00 \uc5c6\uc2b5\ub2c8\ub2e4.<\/p>\n

 <\/p>\n<\/div>\n<\/div>\n

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\uc774\ub3d9 :<\/a><\/div>\n

\ucc38\uace0\uc790\ub8cc<\/h2>\n

 <\/p>\n

\n
1.\u00a0Ren G, Chang F, Lu S, Zhong H, Zhang G. \uc57d\ub9ac\ud559 \uc5f0\uad6c\u00a0\ub2e4\uac01\ud615 capitatum<\/em>\u00a0Buch-Ham.ex D. \ub3c8.\u00a0Chin J Chin Mater Med.\u00a0<\/span>1995;2<\/span>:107\u20139. 28. [\ud37c\ube0c\uba54\ub4dc<\/a>]\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
2.\u00a0Li ML, Liang B, Tang JW, Xie Y, Zuo AP, Du F. \uc950\uc758 Relinqing \uacfc\ub9bd \uc624\uc77c \uc138\uade0\uc131 \uc2e0\uc6b0\uc2e0\uc5fc \ubaa8\ub378\uc758 \uc57d\ub825\ud559 \uc5f0\uad6c.\u00a0Chin J Chin Mater Med.\u00a0<\/span>2006;2<\/span>:153\u20135. [\ud37c\ube0c\uba54\ub4dc<\/a>]\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
3.\u00a0Cheng YS, Wang JY, Hao JJ. \uacfc\ubbfc\uc131 \ubc29\uad11 \uce58\ub8cc\uc5d0 \ub300\ud55c Relinqing \uacfc\ub9bd\uacfc \uad00\ub828\ub41c Tolterodine\uc758 \ud6a8\uacfc.\u00a0\ud131 \uce58\ub8cc Clin.\u00a0<\/span>2012;4<\/span>:500\u20131.\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
4.\u00a0Pereira MA, Grubbs CJ, Barnes LH, Li H, Olson GR, Eto I, \uc678. \uc2dd\ubb3c\ud654\ud559\ubb3c\uc9c8\uc778 \ucee4\ud050\ubbfc\uacfc \ucf00\ub974\uc138\ud2f4\uc774 \uc544\uc871\uc2dc\uba54\ud0c4\uc5d0 \uc758\ud574 \uc720\ubc1c\ub41c \ub300\uc7a5\uc554\uacfc 7,12-\ub514\uba54\ud2f8\ubca4\uc988[a] \uc548\ud2b8\ub77c\uc13c\uc5d0 \uc758\ud574 \uc720\ubc1c\ub41c \uc950\uc758 \uc720\ubc29\uc554\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5.\u00a0\ubc1c\uc554.\u00a0<\/span>1996;6<\/span>:1305-11. [\ud37c\ube0c\uba54\ub4dc<\/a>]\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
5.\u00a0Caltagirone S, Ranelletti FO, Rinelli A, Maggiano N, Colasante A, Musiani P \ub4f1. \uc778\uac04 \ube44\uc18c\uc138\ud3ec\ud3d0\uc554\uc5d0\uc11c \uc81c2\ud615 \uc5d0\uc2a4\ud2b8\ub85c\uac90 \uacb0\ud569 \ubd80\uc704\uc640 \ud0c0\ubaa9\uc2dc\ud39c \ubc0f \ucf00\ub974\uc138\ud2f4\uc758 \ud56d\uc99d\uc2dd \ud65c\uc131\uacfc\uc758 \uc0c1\ud638\uc791\uc6a9.\u00a0Am J Respir Cell Mol Biol.\u00a0<\/span>1997;1<\/span>:51\u20139. [\ud37c\ube0c\uba54\ub4dc<\/a>]\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
6.\u00a0Aviram M, Fuhrman B. \ud3f4\ub9ac\ud398\ub180\uc131 \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc\ub294 LDL\uc758 \ub300\uc2dd\uc138\ud3ec \ub9e4\uac1c \uc0b0\ud654\ub97c \uc5b5\uc81c\ud558\uace0 \uc8fd\uc0c1\ub3d9\ub9e5\uacbd\ud654\uc99d\uc744 \uc57d\ud654\uc2dc\ud0b5\ub2c8\ub2e4.\u00a0\uc8fd\uc0c1 \ub3d9\ub9e5 \uacbd\ud654\uc99d.\u00a0<\/span>1998;137<\/span>(\uacf5\uae09):S45\u201350. [\ud37c\ube0c\uba54\ub4dc<\/a>]\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
7.\u00a0Yan XL, Li CQ, Liu YX, Chang X, Kang WY. Polygonum capitatum\uc758 \ud56d\uc0b0\ud654 \ud65c\uc131.\u00a0\uc9c4\uc57d\ud488.\u00a0<\/span>2010;39<\/span>:3659\u201361.\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
8.\u00a0Siess MH, Leclerc J, Canivenc-Lavier MC, Rat P, Suschetet M. \uc778\uac04\uacfc \uc950\uc758 \uac04 \ub9c8\uc774\ud06c\ub85c\uc19c\uc5d0\uc11c \ubaa8\ub178\uc625\uc2dc\uac8c\ub098\uc81c \ud65c\uc131\uc5d0 \ub300\ud55c \ucc9c\uc5f0 \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc\uc758 \uc774\uc885 \ud6a8\uacfc.\u00a0Toxicol Appl Pharmacol.\u00a0<\/span>1995;1<\/span>:73\u20138. [\ud37c\ube0c\uba54\ub4dc<\/a>]\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
9.\u00a0Agullo G, Gamet-Payrastre L, Manenti S, Viala C, R\u00e9m\u00e9sy C, Chap H, \uc678. \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc \uad6c\uc870\uc640 \ud3ec\uc2a4\ud30c\ud2f0\ub51c\uc774\ub178\uc2dc\ud1a8 3-\ud0a4\ub098\uc544\uc81c \uc5b5\uc81c\uc758 \uad00\uacc4: \ud2f0\ub85c\uc2e0 \ud0a4\ub098\uc544\uc81c\uc640 \ub2e8\ubc31\uc9c8 \ud0a4\ub098\uc544\uc81c C \uc5b5\uc81c\uc640\uc758 \ube44\uad50.\u00a0Biochem Pharmacol.\u00a0<\/span>1997;11<\/span>:1649~57. [\ud37c\ube0c\uba54\ub4dc<\/a>]\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
10.\u00a0Conseil G, Baubichon-Cortay H, Dayan G, Jault JM, Barron D, Di Pietro A. Flavonoids: \ub9c8\uc6b0\uc2a4 P-\ub2f9\ub2e8\ubc31\uc9c8\uc758 ATP \ubc0f \uc2a4\ud14c\ub85c\uc774\ub4dc \uacb0\ud569 \ubd80\uc704\uc5d0\uc11c \uc774\uc911 \uae30\ub2a5 \uc0c1\ud638 \uc791\uc6a9\uc744 \ud558\ub294 \uc870\uc808\uc81c \ud074\ub798\uc2a4\uc785\ub2c8\ub2e4.\u00a0Proc Natl Acad Sci US A.\u00a0<\/span>1998;17<\/span>:9831\u20136.\u00a0[PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[\ud37c\ube0c\uba54\ub4dc<\/a>]\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
11.\u00a0Hertog MG, Kromhout D, Aravanis C, Blackburn H, Buzina R, Fidanza F, \uc678. 7\uac1c\uad6d\uc5d0\uc11c \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc \uc12d\ucde8\uc640 \uad00\uc0c1\ub3d9\ub9e5 \uc2ec\uc7a5 \uc9c8\ud658 \ubc0f \uc554\uc758 \uc7a5\uae30\uc801 \uc704\ud5d8\uc5d0 \ub300\ud574 \uc5f0\uad6c\ud588\uc2b5\ub2c8\ub2e4.\u00a0\uc544\uce58 \uc778\ud134 Med.\u00a0<\/span>1995;4<\/span>:381\u20136. [\ud37c\ube0c\uba54\ub4dc<\/a>]\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
12.\u00a0Liyana-Pathirana C, Shahidi F. \ubc18\uc751 \ud45c\uba74 \ubc29\ubc95\ub860\uc744 \uc0ac\uc6a9\ud558\uc5ec \ubc00\uc5d0\uc11c \ud398\ub180\uc131 \ud654\ud569\ubb3c \ucd94\ucd9c \ucd5c\uc801\ud654.\u00a0\uc2dd\ud488\ud654\ud559.\u00a0<\/span>2005;1<\/span>:47~56.\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
13.\u00a0Li WL, Zheng HC, Bukuru J, De Kimpe N. \ub2f9\ub1e8\ubcd1 \uce58\ub8cc\ub97c \uc704\ud574 \uc804\ud1b5 \uc911\uad6d \uc758\ub8cc \uc2dc\uc2a4\ud15c\uc5d0 \uc0ac\uc6a9\ub418\ub294 \ucc9c\uc5f0 \uc758\uc57d\ud488.\u00a0J Ethnopharmacol.\u00a0<\/span>2004;1<\/span>:1~21. [\ud37c\ube0c\uba54\ub4dc<\/a>]\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
14.\u00a0Normile D. \uc544\uc2dc\uc544 \uc758\ud559. \ud55c\uc758\ud559\uc758 \uc0c8 \uc5bc\uad74.\u00a0\uacfc\ud559.\u00a0<\/span>2003;5604<\/span>:188\u201390. [\ud37c\ube0c\uba54\ub4dc<\/a>]\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
15.\u00a0DeFeudis FV, Drieu K. Ginkgo biloba \ucd94\ucd9c\ubb3c(EGb 761) \ubc0f CNS \uae30\ub2a5: \uae30\ubcf8 \uc5f0\uad6c \ubc0f \uc784\uc0c1 \uc801\uc6a9.\u00a0Curr \uc57d\ubb3c \ud45c\uc801.\u00a0<\/span>2000;1<\/span>:25~58. [\ud37c\ube0c\uba54\ub4dc<\/a>]\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
16.\u00a0Rowland I. \ucd5c\uc801\uc758 \uc601\uc591: \uc12c\uc720\uc9c8 \ubc0f \uc2dd\ubb3c\ud654\ud559\ubb3c\uc9c8.\u00a0Proc Nutr Soc.\u00a0<\/span>1999;02<\/span>:415\u20139. [\ud37c\ube0c\uba54\ub4dc<\/a>]\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
17.\u00a0Yang BB, Feng R, Wang WC, Zhang LY, Ye XM, Wang Y, \uc678. \uba00\uc624\uc871 \uc9c0\uc5ed \uc57d\ucd08\uc778 Polygonum capitatum\uc758 \uc138 \uac00\uc9c0 \ud65c\uc131 \uc131\ubd84\uc744 HPLC\/DAD\/MS\ub85c \uc815\ub7c9 \ubd84\uc11d\ud569\ub2c8\ub2e4.\u00a0Chin J Pharm \ud56d\ubb38.\u00a0<\/span>2008;11<\/span>:1793-6.\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
18.\u00a0Xu J, Zhang YP, Cheng SX. \uc804\uc790\ub808\uc778\uc9c0\ub97c \uc774\uc6a9\ud55c \ucd94\ucd9c\uc5d0 \uad00\ud55c \uc5f0\uad6c\u00a0Polygonum capitatum Buch.-Ham. \uc804-<\/em>\u00a0\ub514.\u00a0Don J Med Pharm \uce5c \ub9c8\uc774\ub108.\u00a0<\/span>2012;8<\/span>:76\u20137.\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
19.\u00a0\uc790\uc624 XC, \ubc14\uc774 H, \uc655 YS, \ub9ac\uc6b0 AQ, \ub9ac GQ. Polygonum capitatum\uc758 \ucd1d\ud50c\ub77c\ubcf4\ub178\uc774\ub4dc \ucd94\ucd9c\uacfc\uc815.\u00a0Lishizhen Med Mater Med Res.\u00a0<\/span>2009;11<\/span>:2815\u20136.\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
20.\u00a0Silva EM, Rogez H, Larondelle Y. \ubc18\uc751 \ud45c\uba74 \ubc29\ubc95\uc744 \uc0ac\uc6a9\ud558\uc5ec Inga edulis \uc78e\uc5d0\uc11c \ud398\ub180\ub9ad \ucd94\ucd9c \ucd5c\uc801\ud654.\u00a0\uc149\ud4e8\ub9ac\ud504\ud14c\ud06c\ub180\ub7ec\uc9c0\u00a0<\/span>2007;3<\/span>:381\u20137.\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
21.\u00a0Tian S, Zhou X, Gong H, Ma X, Zhang F. Paeonia sinjiangensis KY Pan\uc5d0\uc11c \ub2e4\ub2f9\ub958 \ucd94\ucd9c \ucd5c\uc801\ud654\ub97c \uc704\ud55c \uc9c1\uad50 \ud14c\uc2a4\ud2b8 \uc124\uacc4.\u00a0\ud30c\ub9c8\ucf58 \ub9e4\uac70\uc9c4.\u00a0<\/span>2011;25<\/span>:4~8.\u00a0[PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[\ud37c\ube0c\uba54\ub4dc<\/a>]\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
22.\u00a0Arslan-Alaton I, Tureli G, Olmez-Hanci T. Photo-Fenton\uacfc \uc720\uc0ac\ud55c \uace0\uae09 \uc0b0\ud654 \uacf5\uc815\uc744 \uc0ac\uc6a9\ud55c \uc544\uc870 \uc5fc\ub8cc \uc0dd\uc0b0 \ud3d0\uc218 \ucc98\ub9ac: \ubc18\uc751 \ud45c\uba74 \ubc29\ubc95\ub860\uc5d0 \uc758\ud55c \ucd5c\uc801\ud654.\u00a0J Photochem Photobiol A Chem.\u00a0<\/span>2009;2~3<\/span>:142\u201353.\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
23.\u00a0Tang X, Yan L, Gao J, Ge H, Yang H, Lin N. \ucd94\ucd9c \uacf5\uc815 \ucd5c\uc801\ud654 \ubc0f \ubfcc\ub9ac \ub2e4\ub2f9\ub958\uc758 \ud56d\uc0b0\ud654 \ud6a8\uacfc \uc870\uc0ac\u00a0\ub9ac\ubaa8\ub284 \uc2dc\ub128\uc138<\/em>\u00a0Kuntze.\u00a0\ud30c\ub9c8\ucf58 \ub9e4\uac70\uc9c4.\u00a0<\/span>2011;27<\/span>:186\u201392.\u00a0[PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[\ud37c\ube0c\uba54\ub4dc<\/a>]\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
24.\u00a0Ba\u015f D, Boyac\u0131 \u0130H. \ubaa8\ub378\ub9c1 \ubc0f \ucd5c\uc801\ud654 I: \ubc18\uc751 \ud45c\uba74 \ubc29\ubc95\ub860\uc758 \uc720\uc6a9\uc131.\u00a0\uc81c\uc774\ud478\ub4dc\uc5d4\uc9c0\ub2c8\uc5b4\ub9c1\u00a0<\/span>2007;3<\/span>:836\u201345.\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
25.\u00a0Bahorun T, Luximon-Ramma A, Crozier A, Aruoma OI. \ubaa8\ub9ac\uc154\uc2a4 \uc57c\ucc44\uc758 \ucd1d \ud398\ub180, \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc, \ud504\ub85c\uc548\ud1a0\uc2dc\uc544\ub2c8\ub518 \ubc0f \ube44\ud0c0\ubbfc C \uc218\uc900\uacfc \ud56d\uc0b0\ud654 \ud65c\uc131.\u00a0J Sci Food Agric.\u00a0<\/span>2004;12<\/span>:1553-61.\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
26.\u00a0\ub9b0 JY, \ud0d5 CY. \uc120\ud0dd\ub41c \uacfc\uc77c\uacfc \ucc44\uc18c\uc758 \ucd1d \ud398\ub180 \ubc0f \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc \ud568\ub7c9\uc744 \uce21\uc815\ud558\uace0 \ub9c8\uc6b0\uc2a4 \ube44\uc7a5\uc138\ud3ec \uc99d\uc2dd\uc5d0 \ub300\ud55c \uc790\uadf9 \ud6a8\uacfc\ub97c \uce21\uc815\ud569\ub2c8\ub2e4.\u00a0\uc2dd\ud488\ud654\ud559.\u00a0<\/span>2007;1<\/span>:140\u20137.\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
27.\u00a0\uba54\ub2e4 A, Lamien CE, Romito M, Millogo J, Nacoulma OG. \ubd80\ub974\ud0a4\ub098 \ud30c\uc0b0 \uafc0\uc758 \ucd1d \ud398\ub180, \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc \ubc0f \ud504\ub864\ub9b0 \ud568\ub7c9\uacfc \uc774\ub4e4\uc758 \ub77c\ub514\uce7c \uc18c\uac70 \ud65c\uc131\uc744 \uce21\uc815\ud569\ub2c8\ub2e4.\u00a0\uc2dd\ud488\ud654\ud559.\u00a0<\/span>2005;3<\/span>:571\u20137.\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
28.\u00a0Xie Z, Zhao Y, Chen P, Jing P, Yue J, Yu L. Di- \ubc0f 4\ubc30\uccb4 gynostemma pentaphyllum\uc758 \uc78e \ubc0f \uc804\uccb4 \uc2dd\ubb3c \uc0d8\ud50c\uc5d0\uc11c \ud06c\ub85c\ub9c8\ud1a0\uadf8\ub798\ud53c \uc9c0\ubb38 \ubd84\uc11d \ubc0f \ub8e8\ud2f4 \ubc0f \ucf00\ub974\uc138\ud2f4 \uc870\uc131.\u00a0J\ub18d\uc2dd\ud488\ud654\ud559.\u00a0<\/span>2011;7<\/span>:3042\u20139. [\ud37c\ube0c\uba54\ub4dc<\/a>]\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
29.\u00a0Volpi N. \uace0\uc131\ub2a5 \ubaa8\uc138\uad00 \uc804\uae30\uc601\ub3d9\uc744 \uc815\uc81c \uacf5\uc815\uc5d0 \uc801\uc6a9\u00a0\ub300\uc7a5\uade0<\/em>\u00a0K4 \ub2e4\ub2f9\ub958.\u00a0J \ud06c\ub85c\ub9c8\ud1a0\uadf8 B.\u00a0<\/span>2004;2<\/span>:253\u20136. [\ud37c\ube0c\uba54\ub4dc<\/a>]\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n
30.\u00a0Ray B. Enteromorphacompressa\uc758 \ub2e4\ub2f9\ub958: \ubd84\ub9ac, \uc815\uc81c \ubc0f \uad6c\uc870\uc801 \ud2b9\uc9d5.\u00a0\ud0c4\uc218\ud654\ubb3c \uc911\ud569\uccb4.\u00a0<\/span>2006;3<\/span>:408\u201316.\u00a0[\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

Herba Polygoni Capitati, the aerial part or whole plant of Polygonum capitatum Buch.-Ham. ex D. Don, has been used as one of the Traditional Chinese Medicines (TCMs) for a long time in China, especially in some ethnic minority regions.<\/p>","protected":false},"author":1,"featured_media":5353,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9],"tags":[],"class_list":["post-5097","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-supplements"],"_links":{"self":[{"href":"https:\/\/directcm.com\/ko\/wp-json\/wp\/v2\/posts\/5097","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/directcm.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/directcm.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/directcm.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/directcm.com\/ko\/wp-json\/wp\/v2\/comments?post=5097"}],"version-history":[{"count":1,"href":"https:\/\/directcm.com\/ko\/wp-json\/wp\/v2\/posts\/5097\/revisions"}],"predecessor-version":[{"id":5380,"href":"https:\/\/directcm.com\/ko\/wp-json\/wp\/v2\/posts\/5097\/revisions\/5380"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/directcm.com\/ko\/wp-json\/wp\/v2\/media\/5353"}],"wp:attachment":[{"href":"https:\/\/directcm.com\/ko\/wp-json\/wp\/v2\/media?parent=5097"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/directcm.com\/ko\/wp-json\/wp\/v2\/categories?post=5097"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/directcm.com\/ko\/wp-json\/wp\/v2\/tags?post=5097"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}