{"id":5177,"date":"2024-01-16T12:37:46","date_gmt":"2024-01-16T12:37:46","guid":{"rendered":"https:\/\/farlong.com\/?p=5177"},"modified":"2024-01-27T10:26:20","modified_gmt":"2024-01-27T10:26:20","slug":"breviscapine-remodels-myocardial-glucose-and-lipid-metabolism-by-regulating-serotonin-to-alleviate-doxorubicin-induced-cardiotoxicity","status":"publish","type":"post","link":"https:\/\/directcm.com\/ko\/breviscapine-remodels-myocardial-glucose-and-lipid-metabolism-by-regulating-serotonin-to-alleviate-doxorubicin-induced-cardiotoxicity\/","title":{"rendered":"\ube0c\ub808\ube44\uc2a4\uce74\ud540\uc740 \uc138\ub85c\ud1a0\ub2cc\uc744 \uc870\uc808\ud558\uc5ec \ub3c5\uc18c\ub8e8\ube44\uc2e0\uc73c\ub85c \uc778\ud55c \uc2ec\uc7a5 \ub3c5\uc131\uc744 \uc644\ud654\ud568\uc73c\ub85c\uc368 \uc2ec\uadfc \ud3ec\ub3c4\ub2f9\uacfc \uc9c0\uc9c8 \ub300\uc0ac\ub97c \uc7ac\uad6c\uc131\ud569\ub2c8\ub2e4."},"content":{"rendered":"<p>Meng-Jiao Li, 1, 2, \u2020 Wen-She Sun, 1, \u2020 Yang Yuan, 1, \u2020 Yu-Kun Zhang, 1, 2 Qi Lu, 1, 2 Yuan-Zhen Gao, 1, 2 Ting Ye, 1 , 2 \ubc0f Dong-Ming Xing \uad50\uc2e0\uc800\uc790 1 , 3 ,*<\/p>\n<div id=\"abstract-a.k.b.p\" class=\"tsec sec\" lang=\"en\">\n<h2 id=\"abstract-a.k.b.ptitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\ucd94\uc0c1\uc801\uc778<\/h2>\n<div>\n<p class=\"p p-first\"><strong>\ubaa9\ud45c:<\/strong>\u00a0\uad11\ubc94\uc704\ud55c \ud56d\uc554\uc81c\uc778 \ub3c5\uc18c\ub8e8\ube44\uc2e0(Dox)\uc740 \uc2ec\uc7a5\ub3c5\uc131 \ubc1c\uc0dd\ub960\uc774 \ub192\uc544 \uc57d\ubb3c\uc758 \uc784\uc0c1 \uc801\uc6a9\uacfc \ud658\uc790\uc758 \uc0b6\uc758 \uc9c8\uc5d0 \uc2ec\uac01\ud55c \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4. \uc5ec\uae30\uc5d0\uc11c\ub294 Dox\uac00 \uc2ec\uadfc \uc5d0\ub108\uc9c0\uc640 \uc218\ucd95 \uae30\ub2a5\uc744 \uc5b4\ub5bb\uac8c \uc870\uc808\ud558\ub294\uc9c0 \ud3c9\uac00\ud558\uace0 \uc774\ub294 \uad00\ub828 \ubcf4\ud638 \uc57d\ubb3c \uac1c\ubc1c\uc5d0 \ub3c4\uc6c0\uc774 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\ud589\ub3d9 \uc591\uc2dd:<\/strong>\u00a0\ub9c8\uc6b0\uc2a4\uc5d0\uac8c \ub3c5\uc18c\ub8e8\ube44\uc2e0\uacfc \ube0c\ub808\ube44\uc2a4\uce74\ud540 \uce58\ub8cc\ub97c \uc2e4\uc2dc\ud588\uc2b5\ub2c8\ub2e4. \uc2ec\uc7a5 \uae30\ub2a5\uc740 \uc2ec\uc7a5\ucd08\uc74c\ud30c\uac80\uc0ac\ub85c \ubd84\uc11d\ub418\uc5c8\uace0, Dox \ub9e4\uac1c \uc2e0\ud638\uc804\ub2ec\uc740 \ubd84\ub9ac\ub41c \uc2ec\uadfc\uc138\ud3ec\uc5d0\uc11c \ud3c9\uac00\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc758 \uc774\uc911 \uc2ec\uc7a5 \ubcf4\ud638 \ubc0f \ud56d\uc885\uc591 \uc791\uc6a9\uc740 \ub9c8\uc6b0\uc2a4 \uc720\ubc29 \uc885\uc591 \ubaa8\ub378\uc5d0\uc11c \ud3c9\uac00\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\uacb0\uacfc:<\/strong>\u00a0\uc6b0\ub9ac\ub294 Dox\uac00 \ud3ec\ub3c4\ub2f9 \ud761\uc218\ub97c \uac10\uc18c\uc2dc\ud0a4\uace0 \uc9c0\ubc29\uc0b0 \uc0b0\ud654\ub97c \uc99d\uac00\uc2dc\ucf1c \uc2ec\uadfc \uc5d0\ub108\uc9c0 \ub300\uc0ac\ub97c \ubc29\ud574\ud558\uc5ec ATP \uc0dd\uc0b0 \uc18d\ub3c4\ub97c \uac10\uc18c\uc2dc\ud0a4\uace0 \uc0b0\uc18c \uc18c\ube44 \uc18d\ub3c4\uc640 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub97c \uc99d\uac00\uc2dc\ud0a4\uba70 \uc2ec\uadfc \uc9c0\ubc29\uc0b0 \ud761\uc218\ub97c \ud5a5\uc0c1\uc2dc\ud0a4\uace0 DIC\ub97c \uc720\ubc1c\ud558\ub294 \ucd94\uac00 \uc5d0\ub108\uc9c0 \uacb0\ud54d\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. \uac1c\ubc1c. \ud765\ubbf8\ub86d\uac8c\ub3c4, \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc740 \uc138\ub85c\ud1a0\ub2cc-\ud3ec\ub3c4\ub2f9-\uc2ec\uadfc PI3K\/AKT \ub8e8\ud504\ub97c \uc870\uc808\ud558\uc5ec \uc2ec\uc7a5\uc758 \ud3ec\ub3c4\ub2f9 \ud65c\uc6a9\uc744 \uc99d\uac00\uc2dc\ud0a4\uace0 \uc9c0\uc9c8 \uc0b0\ud654\ub97c \uac10\uc18c\uc2dc\ud0b4\uc73c\ub85c\uc368 ATP \uc0dd\uc0b0 \ud6a8\uc728\uc744 \ub192\uc774\uace0 \uc2ec\uadfc \uc5d0\ub108\uc9c0 \ud56d\uc0c1\uc131\uc744 \ud68c\ubcf5\uc2dc\ud0b5\ub2c8\ub2e4. \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc790\uac00\ud3ec\uc2dd\uc744 \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4.\u00a0<em>~\uc744 \ud1b5\ud574<\/em>\u00a0PINK1\/Parkin \uacbd\ub85c\ub294 Dox\ub85c \uc778\ud55c \uc190\uc0c1\ub41c \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ucd95\uc801\uc744 \uc81c\uac70\ud558\uace0 \uc2ec\uc7a5 \uc12c\uc720\uc99d \ubc0f \uc5fc\uc99d \uc815\ub3c4\ub97c \uac10\uc18c\uc2dc\ud0a4\uba70 \uc2ec\uc7a5 \ubbf8\uc138 \ud658\uacbd \ud56d\uc0c1\uc131\uc744 \ubcf5\uc6d0\ud569\ub2c8\ub2e4. \uc911\uc694\ud55c \uac83\uc740 \ub0ae\uc740 \uc5fc\uc99d \uc218\uc900\uc774 \uace8\uc218\uc131 \uba74\uc5ed\uc5b5\uc81c \uc138\ud3ec \uce68\uc724\uc744 \uac10\uc18c\uc2dc\ud0a4\uba70, \uc774 \ud6a8\uacfc\ub294 Dox\uc758 \ud56d\uc885\uc591 \ud6a8\uacfc\uc640 \uc2dc\ub108\uc9c0 \ud6a8\uacfc\uac00 \uc788\ub2e4\ub294 \uac83\uc785\ub2c8\ub2e4.<\/p>\n<p class=\"p p-last\"><strong>\uacb0\ub860:<\/strong>\u00a0\uc6b0\ub9ac\uc758 \uc5f0\uad6c \uacb0\uacfc\ub294 Dox\uc5d0 \uc758\ud55c \uc2ec\uc7a5 \ub300\uc0ac \ub124\ud2b8\uc6cc\ud06c\uc758 \ud30c\uad34\uac00 \uc2ec\uc7a5 \ub3c5\uc131\uc758 \uc911\uc694\ud55c \ub3d9\uc778\uc774\uba70 \uc138\ub85c\ud1a0\ub2cc\uc774 \uc2ec\uadfc \ud3ec\ub3c4\ub2f9 \ubc0f \uc9c0\uc9c8 \ub300\uc0ac\uc758 \uc911\uc694\ud55c \uc870\uc808\uc790\uc784\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. \uc2ec\uadfc \uc5d0\ub108\uc9c0 \ud56d\uc0c1\uc131\uacfc \uc190\uc0c1\ub41c \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uc758 \uc801\uc2dc \uc81c\uac70\ub294 \uc2dc\ub108\uc9c0\uc801\uc73c\ub85c \uc548\ud2b8\ub77c\uc0ac\uc774\ud074\ub9b0\uc73c\ub85c \uc778\ud55c \uc2ec\uc7a5 \ub3c5\uc131 \uc608\ubc29\uc5d0 \uae30\uc5ec\ud558\uace0 \uc885\uc591 \uce58\ub8cc \ud6a8\uc728\uc131\uc744 \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4.<\/p>\n<\/div>\n<div class=\"sec\"><strong class=\"kwd-title\">\ud0a4\uc6cc\ub4dc:\u00a0<\/strong><span class=\"kwd-text\">\ub3c5\uc18c\ub8e8\ube44\uc2e0, DIC, \ube0c\ub808\ube44\uc2a4\uce74\ud540, \uc138\ub85c\ud1a0\ub2cc, PINK1\/\ud30c\ud0a8<\/span><\/div>\n<\/div>\n<div id=\"s1\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\uc774 \ud398\uc774\uc9c0\uc758 \ub2e4\ub978 \uc139\uc158\uc73c\ub85c \uc774\ub3d9\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc774\ub3d9 :<\/a><\/div>\n<h2 id=\"s1title\" class=\"head no_bottom_margin ui-helper-clearfix\">\uc18c\uac1c<\/h2>\n<p class=\"p p-first\">\uc548\ud2b8\ub77c\uc0ac\uc774\ud074\ub9b0 \ud56d\uc0dd\uc81c\uc778 \ub3c5\uc18c\ub8e8\ube44\uc2e0(Dox)\uc740 \uace0\ud615 \uc885\uc591, \ubc31\ud608\ubcd1, \ub9bc\ud504\uc885 \ubc0f \uc720\ubc29\uc554 \uce58\ub8cc\uc5d0 \ub9e4\uc6b0 \ud6a8\uacfc\uc801\uc778 \ud56d\uc554\uc81c\uc785\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B43\" aria-expanded=\"false\" aria-haspopup=\"true\">\ub2e4\ucf00\ubb34\ub77c\uc640 \ud6c4\uc9c0\uc640\ub77c, 2007<\/a>). Dox \uc0ac\uc6a9\uc740 Dox \uc720\ubc1c \uc2ec\uadfc\ubcd1\uc99d(DIC)\uc73c\ub85c \uc54c\ub824\uc9c4 \uc9c4\ud589\uc131, \ub9cc\uc131, \uc0dd\uba85\uc744 \uc704\ud611\ud558\ub294 \uc2ec\uadfc\ubcd1\uc99d\uc73c\ub85c \uc774\uc5b4\uc9c8 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B20\" aria-expanded=\"false\" aria-haspopup=\"true\">\ub9ac\ubc14\uc774\uc2a4 \uc678, 2017<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B37\" aria-expanded=\"false\" aria-haspopup=\"true\">Sawicki \uc678, 2021<\/a>). \ud2b9\ud788 \uc554 \ud658\uc790\uc758 \uacbd\uc6b0 \uc57d\ubb3c \uad00\ub828 \uc2ec\uc7a5 \ub3c5\uc131\uc73c\ub85c \uc778\ud55c \uc0ac\ub9dd \uc704\ud5d8\uc774 \uc885\uc591 \uc790\uccb4\ub098 \uc7ac\ubc1c\ub85c \uc778\ud55c \uc0ac\ub9dd \uc704\ud5d8\uc744 \ucd08\uacfc\ud569\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B24\" aria-expanded=\"false\" aria-haspopup=\"true\">\ub9ac\uc6b0 \uc678, 2017<\/a>). \uac1c\uc778\uc758 \uac10\uc218\uc131\uc5d0 \ub530\ub77c \uc800\uc6a9\ub7c9 Dox \ud22c\uc5ec \ud6c4 \uc2ec\uc7a5 \ub3c5\uc131\uc73c\ub85c \uc778\ud55c DIC\uac00 \ubc1c\uc0dd\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B27\" aria-expanded=\"false\" aria-haspopup=\"true\">\ub9e5\uace0\uc644 \uc678., 2017<\/a>). \uc5ed\ud559 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \ube44\ub9cc, \ub2f9\ub1e8\ubcd1, \uac04 \uc9c8\ud658\uacfc \uac19\uc740 \ub300\uc0ac \uc774\uc0c1\uc73c\ub85c \uc778\ud574 DIC \uc704\ud5d8\uc774 \uc99d\uac00\ud558\uace0 Dox\uac00 \uc2ec\uc7a5\uc758 \ud3ec\ub3c4\ub2f9 \ud761\uc218\ub97c \uac15\ub825\ud558\uac8c \uac10\uc18c\uc2dc\ud0a4\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \uc774\ub294 Dox\uac00 DIC\uc758 \ubc1c\uc0dd\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. \uc2ec\uc7a5\uc758 \ub300\uc0ac\ubbf8\uc138\ud658\uacbd. \ucd5c\uadfc DIC\uc758 \uc7a0\uc7ac\uc801\uc778 \ubd84\uc790 \uba54\ucee4\ub2c8\uc998\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub294 \uc0b0\ud654\ud658\uc6d0 \ud56d\uc0c1\uc131 \ubd88\uade0\ud615, \ud1a0\ud3ec\uc774\uc18c\uba38\ub77c\uc81c II\u03b2(Top2b) \uc804\uc0ac \uc5b5\uc81c, \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5 \uc7a5\uc560 \ubc0f Ca\uc5d0 \ucd08\uc810\uc744 \ub9de\ucd94\uace0 \uc788\uc2b5\ub2c8\ub2e4.<sup>2+<\/sup>-\uc774\uc0c1 \ucc98\ub9ac(<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B45\" aria-expanded=\"false\" aria-haspopup=\"true\">\ubca0\uc988\ud401\uc0ac\uc640 \uc608, 2014<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B15\" aria-expanded=\"false\" aria-haspopup=\"true\">\uce7c\uc57c\ub098\ub77c\ub9cc, 2020<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B13\" aria-expanded=\"false\" aria-haspopup=\"true\">\ud5d0\uc2a4\ud2b8 \uc678, 2021<\/a>). \uc2ec\uc7a5\uc740 \uc2e0\uccb4\uc5d0\uc11c \uac00\uc7a5 \ub9ce\uc740 \uc591\uc758 \uc5d0\ub108\uc9c0\ub97c \uc18c\ube44\ud558\uba70 Dox\ub294 \uc2ec\uc7a5 \ub300\uc0ac\ub97c \uc7ac\uad6c\uc131\ud569\ub2c8\ub2e4. \uadf8\ub7ec\ub098 DIC \uac1c\ubc1c\uc744 \uc8fc\ub3c4\ud558\ub294 \ubcc0\uacbd \uc0ac\ud56d\uc740 \uc644\uc804\ud788 \uc774\ud574\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \uc2ec\uc7a5 \ub300\uc0ac \ub124\ud2b8\uc6cc\ud06c\uc758 \uc870\uc808\uc744 \ud1b5\ud574 DIC\ub97c \uc608\ubc29\ud558\ub294 \uce58\ub8cc \uc804\ub7b5\uc740 \ud655\ub9bd\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\uc2ec\uc7a5 \uc5d0\ub108\uc9c0 \ub300\uc0ac\uc5d0\ub294 ATP \uc0dd\uc0b0 \ub610\ub294 \uc0dd\ud569\uc131\uc744 \uc704\ud574 \uac01 \ud074\ub798\uc2a4\uc758 \uc5d0\ub108\uc9c0 \uae30\uc9c8\uc744 \uc0ac\uc6a9\ud558\uac8c \ub418\ub294 \ubcf5\uc7a1\ud55c \uc0c1\ud638 \uc791\uc6a9 \uacbd\ub85c \uc138\ud2b8\uac00 \ud3ec\ud568\ub429\ub2c8\ub2e4. \ub124\ud2b8\uc6cc\ud06c\uc758 \uac00\uc7a5 \ub450\ub4dc\ub7ec\uc9c4 \ud2b9\uc9d5\uc740 \ubc1c\ub2ec \ubcc0\ud654, \uc601\uc591 \uc0c1\ud0dc, \ub9cc\uc131 \ubcd1\ub9ac\uc0dd\ub9ac\ud559\uc801 \uc0c1\ud0dc \ubc0f \uc57d\ub9ac\ud559\uc801 \uac1c\uc785\uc744 \ud3ec\ud568\ud55c \ub2e4\uc591\ud55c \uc790\uadf9\uc5d0 \ubc18\uc751\ud558\uc5ec \uc785\uc99d\ub41c \ub300\uc0ac \uc720\uc5f0\uc131\uc785\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B29\" aria-expanded=\"false\" aria-haspopup=\"true\">\ubb34\ub77c\uc2dc\uac8c \uc678, 2020<\/a>). \uc2ec\uadfc\uc138\ud3ec \ubd80\ud53c\uc758 1\/3\uc744 \ucc28\uc9c0\ud558\uace0 \uc2ec\uc7a5\uc5d0\uc11c \uc0ac\uc6a9\ub418\ub294 ATP\uc758 95% \uc774\uc0c1\uc744 \uc0dd\uc131\ud560 \ubfd0\ub9cc \uc544\ub2c8\ub77c \uc138\ud3ec \ub0b4 \uce7c\uc298 \ud56d\uc0c1\uc131, \uc2e0\ud638 \uc804\ub2ec \ubc0f \uc138\ud3ec \uc0ac\uba78\uc744 \uc870\uc808\ud558\ub294 \ub2e4\ubaa9\uc801 \uc18c\uae30\uad00\uc778 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\ub294 \uc5d0\ub108\uc9c0 \uc870\ud654\uc758 \ud575\uc2ec\uc785\ub2c8\ub2e4. \ubcc0\ud658(<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B18\" aria-expanded=\"false\" aria-haspopup=\"true\">\ucf5c\uc704\uce20 \uc678, 2013<\/a>). \uc2ec\uc7a5\uc740 ATP \uc0dd\uc0b0\uc744 \uc704\ud574 \ud0c4\uc218\ud654\ubb3c, \uc9c0\uc9c8, \uc544\ubbf8\ub178\uc0b0, \ucf00\ud1a4\uccb4\ub97c \ud3ec\ud568\ud55c \ubaa8\ub4e0 \uc885\ub958\uc758 \uc5d0\ub108\uc9c0 \uae30\uc9c8\uc744 \ud65c\uc6a9\ud560 \uc218 \uc788\uc9c0\ub9cc \uc0ac\uc6a9\ub418\ub294 \uae30\uc9c8\uc740 \uc2ec\uc7a5 \ud6a8\uc728\uc131\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4. \uc99d\uac00\ub41c \uc9c0\ubc29\uc0b0 \ub18d\ub3c4\uc640 \uc0b0\ud654\ub294 \ube44\ub9cc\uacfc \ub2f9\ub1e8\ubcd1\uc758 \ub9e5\ub77d\uc5d0\uc11c \uac10\uc18c\ub41c \ud3ec\ub3c4\ub2f9 \uc0b0\ud654\uc640 \uad00\ub828\uc774 \uc788\uc2b5\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B34\" aria-expanded=\"false\" aria-haspopup=\"true\">\ub79c\ub4e4 \uc678, 1963<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B23\" aria-expanded=\"false\" aria-haspopup=\"true\">\ub9ac\uc640 \uc7a5, 2016<\/a>). \uc2ec\uc7a5 \uae30\ub2a5 \uc7a5\uc560\ub294 \uc2ec\uadfc \uc0b0\uc18c \uc18c\ube44 \uc99d\uac00, \uc2ec\uc7a5 \ud6a8\uc728\uc131 \uac10\uc18c, \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4 \uc99d\uac00\uc640 \uc5f0\uad00\ub418\uc5b4 \uc788\uc73c\uba70, \uc774\ub294 \uc9c0\ubc29\uc0b0 \uc0b0\ud654(FAO) \uc99d\uac00\uac00 \uc2ec\uc7a5 \uae30\ub2a5\uc5d0 \ud574\ub86d\ub2e4\ub294 \uac83\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B25\" aria-expanded=\"false\" aria-haspopup=\"true\">Lopaschuk \uc678, 2010<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B26\" aria-expanded=\"false\" aria-haspopup=\"true\">Lopaschuk \uc678, 2021<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B54\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc57c\ub9c8\ubaa8\ud1a0\uc640 \uc0ac\ub178, 2022<\/a>). \ub192\uc740 FAO\uc758 \ubd80\uc791\uc6a9\uc744 \ub4b7\ubc1b\uce68\ud558\ub294 \ud55c \uac00\uc9c0 \uba54\ucee4\ub2c8\uc998\uc740 \uc0b0\uc18c \ud6a8\uc728\uc758 \uac10\uc18c\uc640 \uc9c0\ubc29\uc0b0 \uc720\ub3c4\uccb4 \uc218\uc900\uc758 \uc99d\uac00\uc774\uba70, \uc774\ub294 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uc758 \uacb0\ud569\uc744 \ud574\uc81c\ud558\uc5ec \ud6a8\uc728\uc131\uc744 \ub354\uc6b1 \uac10\uc18c\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc2e4\uc81c\ub85c DIC\uc5d0\uc11c \uc9c0\uc9c8 \uacfc\uc0b0\ud654(LP)\uc758 \uc0c1\uc2b9\uc774 \uad00\ucc30\ub418\ub294\ub370, \uc774\ub294 \ub192\uc740 FAO\uac00 \uc2ec\uc7a5 \uc190\uc0c1\uc758 \uc8fc\uc694 \uacbd\ub85c\uc77c \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc6b0\ub9ac\ub294 Dox \uce58\ub8cc \uc911 \uc2ec\uc7a5 \ub300\uc0ac \ub9ac\ubaa8\ub378\ub9c1\uc774 \uc9c0\ubc29\uc0b0 \ud761\uc218 \ubc0f \uc0b0\ud654\ub97c \uc99d\uac00\uc2dc\ucf1c \ub192\uc740 \uc0b0\uc18c \uc18c\ube44 \ubc0f \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\uc640 \ud568\uaed8 ATP \uc0dd\uc0b0 \ud6a8\uc728\uc774 \ub0ae\uc544\uc9c0\uace0 \uc2ec\uc7a5 \ud6a8\uc728\uc774 \uac10\uc18c\ud558\uc5ec \uacb0\uacfc\uc801\uc73c\ub85c \uc9c0\ubc29\uc0b0 \ud65c\uc6a9\uc774 \ud5a5\uc0c1\ub41c\ub2e4\ub294 \uac00\uc124\uc744 \uc138\uc6e0\uc2b5\ub2c8\ub2e4. \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc190\uc0c1\uc73c\ub85c \uc778\ud574 DIC\uc758 \uc9c4\ud589\uc774 \uac00\uc18d\ud654\ub429\ub2c8\ub2e4.<\/p>\n<p>\ud765\ubbf8\ub86d\uac8c\ub3c4 \uc5ed\ud559 \uc5f0\uad6c\uc5d0\uc11c\ub294 \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc\uac00 \ud48d\ubd80\ud55c \uc2dd\ud488\uc744 \uc815\uae30\uc801\uc73c\ub85c \uc12d\ucde8\ud558\uba74 \ub9ce\uc740 \uc2ec\ud608\uad00 \uc9c8\ud658\uc758 \uc704\ud5d8\uc744 \uc904\uc77c \uc218 \uc788\uc73c\uba70 \ub9ce\uc740 \ucc9c\uc5f0 \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc \ud654\ud569\ubb3c\uc774 \uc2ec\uc7a5 \uae30\ub2a5\uc744 \ubcf4\ud638\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B38\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc0e4\ubc1c\ub77c\ub77c \uc678, 2017<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B42\" aria-expanded=\"false\" aria-haspopup=\"true\">Syahputra \uc678, 2022<\/a>).\u00a0<em>Erigeron breviscapus<\/em>, \ub610\ud55c ~\uc73c\ub85c \uc54c\ub824\uc9c4\u00a0<em>\uc544\uc170\ub974\ud30c \ube0c\ub808\ube44\uc2a4\uce74\ud540<\/em>\u00a0\ub610\ub294 Apocynum\uc740 600\ub144 \ub118\uac8c \uc0ac\uc6a9\ub418\uc5b4 \uc628 \uc804\ud1b5\uc801\uc778 \ud5c8\ube0c\uc785\ub2c8\ub2e4. \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc740 \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc \uc131\ubd84\uc785\ub2c8\ub2e4.\u00a0<em>Erigeron breviscapus<\/em>\u00a0\ud56d\uc0b0\ud654, \ud56d\uc5fc\uc99d, \ud56d\uc885\uc591 \ud6a8\uacfc \ub4f1 \uad11\ubc94\uc704\ud55c \uc57d\ub9ac\uc791\uc6a9\uc744 \uac00\uc9c0\uace0 \uc788\ub294<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B10\" aria-expanded=\"false\" aria-haspopup=\"true\">\uac00\uc624 \uc678, 2017<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B48\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc6ec \uc678., 2021<\/a>). \ube0c\ub808\ube44\uc2a4\uce74\ud540 \uc8fc\uc0ac\ub294 \uc911\uad6d\uc5d0\uc11c \uc2ec\ud608\uad00 \ubc0f \ub1cc\ud608\uad00 \uc9c8\ud658 \uce58\ub8cc\uc5d0 \uac00\uc7a5 \ub110\ub9ac \uc0ac\uc6a9\ub418\ub294 \uace0\uc804 \uc57d\ubb3c\uc774\uba70 \uc911\uad6d \ubcd1\uc6d0\uc758 \uc751\uae09 \uce58\ub8cc\uc5d0\ub3c4 \uc911\uc694\ud55c \uc57d\ubb3c\uc785\ub2c8\ub2e4. \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc740 \uace0\ud608\uc555, \ub1cc\uc0c9\uc804\uc99d, \ub1cc\ud608\uad00\uc9c8\ud658 \uce58\ub8cc\uc5d0 20\ub144 \uc774\uc0c1 \uc784\uc0c1\uc801\uc73c\ub85c \uc801\uc6a9\ub418\uc5b4 \uc654\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B50\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc6b0 \uc678., 2019<\/a>). \uadf8\ub7ec\ub098 \ud604\uc7ac \ud654\ud559\uc694\ubc95 \uc57d\ubb3c\ub85c \uc778\ud55c \uc2ec\uc7a5 \uc190\uc0c1\uc5d0 \ub300\ud55c \ubcf4\ud638 \ud6a8\uacfc\uc5d0 \ub300\ud55c \ubcf4\uace0\ub294 \uc5c6\uc2b5\ub2c8\ub2e4.<\/p>\n<p class=\"p p-last\">\uc774 \uc5f0\uad6c\uc5d0\uc11c \uc6b0\ub9ac\ub294 H9c2 \uc950 \uc2ec\uadfc \uc138\ud3ec\uc640 C57BL\/6 \ub9c8\uc6b0\uc2a4\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc548\ud2b8\ub77c\uc0ac\uc774\ud074\ub9b0 \uc720\ubc1c \uc2ec\uadfc \uc190\uc0c1 \ubaa8\ub378\uc744 \ud655\ub9bd\ud568\uc73c\ub85c\uc368 DIC\uc5d0 \ub300\ud55c \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc758 \uc7a0\uc7ac\uc801 \ud6a8\uacfc\uc640 \uac00\ub2a5\ud55c \ubd84\uc790 \uba54\ucee4\ub2c8\uc998\uc744 \uc870\uc0ac\ud588\uc2b5\ub2c8\ub2e4. \uc6b0\ub9ac\ub294 \ub610\ud55c \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc774 \ud3ec\ub3c4\ub2f9 \uc870\uc808 \ubd84\uc9c0\ud615 \uc138\ub85c\ud1a0\ub2cc \uacbd\ub85c\ub97c \ud1b5\ud574 \uc2ec\uadfc \ud3ec\ub3c4\ub2f9 \ud65c\uc6a9 \ud6a8\uc728\uc744 \ud5a5\uc0c1\uc2dc\ucf1c \uc778\uc290\ub9b0 \uc720\uc0ac \uae30\ub2a5\uc744 \ubc1c\ud718\ud558\uc5ec \ub0ae\uc740 \uc0b0\uc18c \uc18c\ube44 \ub3d9\uc548 \ub192\uc740 ATP \uc0dd\uc0b0 \ud6a8\uc728\uacfc \ub0ae\uc740 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4 \uc218\uc900\uc744 \ub2ec\uc131\ud560 \uc218 \uc788\uc74c\uc744 \uccb4\uacc4\uc801\uc73c\ub85c \ubc1d\ud614\uc2b5\ub2c8\ub2e4. \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 PINK1\/Parkin \uc790\uac00\ud3ec\uc2dd \uacbd\ub85c\ub294 Dox\uc5d0 \uc758\ud574 \uc720\ubc1c\ub41c \uc190\uc0c1\ub41c \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uc758 \ucd95\uc801\uc744 \uc81c\uac70\ud558\uace0 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\uc640 \uc5d0\ub108\uc9c0 \uc0dd\uc0b0\uc758 \uc870\uc808\uc744 \uc870\uc815\ud558\uba70 \uc810\ucc28\uc801\uc73c\ub85c \uc2ec\uc7a5 \ubbf8\uc138 \ud658\uacbd\uc758 \ud56d\uc0c1\uc131\uc744 \ud68c\ubcf5\uc2dc\ud0b5\ub2c8\ub2e4. \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc740 \ub3c5\uc18c\ub8e8\ube44\uc2e0 \uc720\ubc1c \uc2ec\uc7a5\ub3c5\uc131\uc5d0 \ub300\ud55c \uc7a0\uc7ac\uc801\uc778 \uc0c8\ub85c\uc6b4 \ubcf4\ud638\uc81c\ub77c\uace0 \uc0dd\uac01\ub429\ub2c8\ub2e4.<\/p>\n<\/div>\n<div id=\"s2\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\uc774 \ud398\uc774\uc9c0\uc758 \ub2e4\ub978 \uc139\uc158\uc73c\ub85c \uc774\ub3d9\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc774\ub3d9 :<\/a><\/div>\n<h2 id=\"s2title\" class=\"head no_bottom_margin ui-helper-clearfix\">\uc7ac\ub8cc \ubc0f \ubc29\ubc95<\/h2>\n<p class=\"p p-first\">\ubaa8\ub4e0 \ub3d9\ubb3c \uc5f0\uad6c\ub294 \uce6d\ub2e4\uc624\ub300\ud559\uad50 \ub3d9\ubb3c \uad00\ub9ac \ubc0f \uc0ac\uc6a9 \uc704\uc6d0\ud68c\uc758 \uc9c0\uce68\uc5d0 \ub530\ub77c \uc2b9\uc778\ub418\uace0 \uc218\ud589\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n<div id=\"s2-1\" class=\"sec\">\n<h3 id=\"s2-1title\">\uc2dc\uc57d<\/h3>\n<p class=\"p p-first-last\">\ub2e4\uc74c \uc2dc\uc57d\uc774 \uc0ac\uc6a9\ub418\uc5c8\uc2b5\ub2c8\ub2e4: DMEM, FBS, \ud398\ub2c8\uc2e4\ub9b0\/\uc2a4\ud2b8\ub819\ud1a0\ub9c8\uc774\uc2e0(Meilunbio, Dalian, China), cTnI Elisa \ud0a4\ud2b8(Sangon Biotech, Shanghai, China), TNF-\u03b1, IL-1\u03b2 \ubc0f IL-6 Elisa \ud0a4\ud2b8(MyBioSource, \ubbf8\uad6d \uc0cc\ub514\uc5d0\uc774\uace0), MDA \ud0a4\ud2b8, SOD \ud0a4\ud2b8, NADH \ud0a4\ud2b8(Solarbio, \uc911\uad6d \ubca0\uc774\uc9d5), CCK-8 \ud0a4\ud2b8(Beyotime Biotechnology, \uc911\uad6d \uc0c1\ud558\uc774), ROS \ud615\uad11 \uce21\uc815 \ud0a4\ud2b8, JC-1 \ud615\uad11\uc5fc\ub8cc, \ub2e8\ubc31\uc9c8 \ucd94\ucd9c \ud0a4\ud2b8 \ubc0f BCA \ud0a4\ud2b8(Meilunbio, \uc911\uad6d \ub2e4\ub844). IL-1(1:100), PINK1(1:1,000), \ud30c\ud0a8(1:1,000), AMPK(1:1,000), Akt(1:1,000), P13K(1:1,000), Tom20(1:1,000) , \u03b2-tubulin(1:1,000), mTOR(1:1,000) \ubc0f HRP \uacb0\ud569 GAPDH(1:1,000) \ud56d\uccb4\ub294 Abclonal Biotechnology(Wuhan, China)\uc5d0\uc11c \uad6c\uc785\ud588\uc2b5\ub2c8\ub2e4. RIPA \uc6a9\ud574 \uc644\ucda9\uc561\uacfc \ub85c\ub529 \uc644\ucda9\uc561\uc740 Meilunbio(\uc911\uad6d \ub2e4\ub844)\uc5d0\uc11c \uad6c\uc785\ud588\uc2b5\ub2c8\ub2e4. PVDF \uba64\ube0c\ub808\uc778\uc740 Merck(\ubbf8\uad6d \ub274\uc800\uc9c0 \uc18c\uc7ac)\uc5d0\uc11c \uad6c\uc785\ud588\uc2b5\ub2c8\ub2e4. DMSO\ub294 Macklin(\uc911\uad6d \uc0c1\ud558\uc774)\uc5d0\uc11c \uad6c\uc785\ud588\uace0, doxorubicin, breviscapine, dexrazoxane\uc740 Widely(\uc911\uad6d \uc6b0\ud55c)\uc5d0\uc11c \uad6c\uc785\ud588\uc2b5\ub2c8\ub2e4. Mdivi-1 \uc5b5\uc81c\uc81c\ub294 Selleck Chemicals(Houston, United States)\uc5d0\uc11c \uad6c\uc785\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<\/div>\n<div id=\"s2-2\" class=\"sec\">\n<h3 id=\"s2-2title\">\uc138\ud3ec \ubc30\uc591 \uc870\uac74 \ubc0f \uc138\ud3ec\uc8fc<\/h3>\n<p class=\"p p-first\">\uc138\ud3ec\ubc30\uc591\uc744 \uc704\ud55c \ubc30\uc591\ubc30\uc9c0\uc640 \ubcf4\ucda9\uc81c\ub294 Gibco-Invitrogen(Carlsbad, CA, United States)\uc5d0\uc11c \uad6c\uc785\ud558\uc600\uace0, \ud50c\ub77c\uc2a4\ud2f1 \uc81c\ud488\uc740 Corning(Corning, NY, United States)\uc5d0\uc11c \uad6c\uc785\ud558\uc600\uc2b5\ub2c8\ub2e4. H9c2 \ubc30\uc544 \uc950 \uc2ec\uc7a5 \uc720\ub798 \uc2ec\uadfc \uc544\uc138\ud3ec(ATCC, CRL-1446)\ub97c 10% \uc18c \ud0dc\uc544 \ud608\uccad, 100 \ub2e8\uc704\/ml \ud398\ub2c8\uc2e4\ub9b0 G \ub098\ud2b8\ub968 \ubc0f 100 \u03bcg\/ml \ud669\uc0b0 \uc2a4\ud2b8\ub819\ud1a0\ub9c8\uc774\uc2e0(37\u00b0C, 5% CO)\uc774 \ud3ec\ud568\ub41c DMEM\uc5d0\uc11c \ubc30\uc591\ud588\uc2b5\ub2c8\ub2e4.<sub>2<\/sub>). MCF-7 \uc778\uac04 \uc804\uc774\uc131 \uc720\ubc29\uc554 \uc138\ud3ec(iCell, iCell-h129)\ub97c 10% \uc18c \ud0dc\uc544 \ud608\uccad, 100 \ub2e8\uc704\/ml \ud398\ub2c8\uc2e4\ub9b0 G \ub098\ud2b8\ub968 \ubc0f 100 \u03bcg\/ml \ud669\uc0b0 \uc2a4\ud2b8\ub819\ud1a0\ub9c8\uc774\uc2e0\uc774 \ubcf4\ucda9\ub41c 1,640\uac1c \ubc30\uc9c0\uc5d0\uc11c \ubc30\uc591\ud588\uc2b5\ub2c8\ub2e4. 4T1 \ub9c8\uc6b0\uc2a4 \uc720\ubc29\uc554 \uc138\ud3ec(ATCC, FS-0158)\ub97c 10% \uc18c \ud0dc\uc544 \ud608\uccad, 100 \ub2e8\uc704\/ml \ud398\ub2c8\uc2e4\ub9b0 G \ub098\ud2b8\ub968 \ubc0f 100 \u03bcg\/ml \ud669\uc0b0 \uc2a4\ud2b8\ub819\ud1a0\ub9c8\uc774\uc2e0\uc774 \ubcf4\ucda9\ub41c DMEM \ubc30\uc9c0\uc5d0\uc11c \ubc30\uc591\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p class=\"p p-last\">\uc138\ud3ec\uac00 80-90% \ud569\ub958\uc810\uc5d0 \ub3c4\ub2ec\ud558\uba74 \uc815\uae30\uc801\uc73c\ub85c \uacc4\ub300\ubc30\uc591\ud558\uace0 96\uc6f0 \ud50c\ub808\uc774\ud2b8(1 x 10<sup>4<\/sup>\u00a0\uc138\ud3ec\/\uc6f0). H9c2 \uc138\ud3ec\ub97c \ub300\uc870\uad70\uc778 5 \u03bcM Dox(<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B12\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uc624 \uc678., 2013<\/a>), 5\u03bcM Dox+20\u03bcM Dexra(<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B35\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc0c1\uc6e8\ub2c8 \uc678, 2020<\/a>) \ub610\ub294 5\u03bcM Dox+200\u03bcM \ube0c\ub808\ube44\uc2a4\uce74\ud540(<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B22\" aria-expanded=\"false\" aria-haspopup=\"true\">\ub9ac \uc678, 2022<\/a>) \uac01\uac01 24\uc2dc\uac04 \ub3d9\uc548. DMEM\ub9cc \ucc98\ub9ac\ud55c \uc138\ud3ec\ub97c \uacf5\ubc31 \ub300\uc870\uad70\uc73c\ub85c \uc0ac\uc6a9\ud558\uc600\uace0, \uc591\uc131 \ub300\uc870\uad70\uc73c\ub85c Dexra\ub97c \uc0ac\uc6a9\ud558\uc600\ub2e4. \ub9c8\uc9c0\ub9c9\uc73c\ub85c \uc6b0\ub9ac\ub294 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ubd84\uc5f4 \uc5b5\uc81c\uc81c\uc778 Mdivi-1(5\u03bcM, DMSO)\ub3c4 \uc8fc\uc785\ud588\uc2b5\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B30\" aria-expanded=\"false\" aria-haspopup=\"true\">Nhu \uc678, 2021<\/a>).<\/p>\n<\/div>\n<div id=\"s2-3\" class=\"sec\">\n<h3 id=\"s2-3title\">\uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4 \ud3c9\uac00<\/h3>\n<p class=\"p p-first-last\">\uc138\ud3ec\ub0b4 ROS \uc218\uc900\uc740 \uc81c\uc870\uc5c5\uccb4\uc758 \uc9c0\uce68\uc5d0 \ub530\ub77c \ud615\uad11 \uc5fc\ub8cc DCFH-DA\ub97c \uc0ac\uc6a9\ud558\uc5ec \uce21\uc815\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uac04\ub7b5\ud558\uac8c \ub9d0\ud558\uba74, DCFH-DA \uc6a9\uc561(1 \u03bcM)\uc744 PBS\uc5d0\uc11c \uc81c\uc870\ud558\uace0 6-\uc6f0 \ud50c\ub808\uc774\ud2b8\uc5d0\uc11c \ubc30\uc591\ub41c H9c2 \uc138\ud3ec\uc5d0 \ucca8\uac00\ud55c \ud6c4 37\u00b0C\uc5d0\uc11c 30\ubd84 \ub3d9\uc548 \ubc30\uc591\ud588\uc2b5\ub2c8\ub2e4. \uc778\ud050\ubca0\uc774\uc158 \ud6c4, \uc138\ud3ec\ub97c PBS\ub85c \uc138\ucc99\ud558\uc600\ub2e4. \ud615\uad11 \ud604\ubbf8\uacbd \uc0ac\uc9c4\uc740 Leica Microsystems, Ltd.\uc758 \ud615\uad11 \ud604\ubbf8\uacbd\uc744 \uc0ac\uc6a9\ud558\uc5ec 20\u00d7 \ubc30\uc728\ub85c \ucd2c\uc601\ud588\uc2b5\ub2c8\ub2e4. ROS \uc218\uc900\uc740 Beckman \uc720\uc138\ud3ec \ubd84\uc11d\uae30(Beckman, California, United States)\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc815\ub7c9\ud654\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<\/div>\n<div id=\"s2-4\" class=\"sec\">\n<h3 id=\"s2-4title\">\ud6a8\uc18c \uc9c0\uc218\uc758 \uacb0\uc815<\/h3>\n<p class=\"p p-first-last\">SOD \ubc0f NADH\uc758 \ud65c\uc131\uc740 \uc81c\uc870\uc5c5\uccb4\uc758 \uc9c0\uce68\uc5d0 \ub530\ub77c \ud65c\uc131 \ubd84\uc11d \ud0a4\ud2b8\ub97c \uc0ac\uc6a9\ud558\uc5ec \uce21\uc815\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ud761\uad11\ub3c4\uc640 \ubc1c\uad11\uc131\uc740 \ub9c8\uc774\ud06c\ub85c\ud50c\ub808\uc774\ud2b8 \ub9ac\ub354(Perkin Elmer, Massachusetts, United States)\ub97c \uc0ac\uc6a9\ud558\uc5ec \uce21\uc815\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n<\/div>\n<div id=\"s2-5\" class=\"sec\">\n<h3 id=\"s2-5title\">\uc804\uc790\ud604\ubbf8\uacbd<\/h3>\n<p class=\"p p-first-last\">\uc138\ud3ec\ub97c 0.5% \uae00\ub8e8\ud0c0\ub974\uc54c\ub370\ud788\ub4dc \uace0\uc815\uc81c\ub85c 4\u00b0C\uc5d0\uc11c 15~30\ubd84\uac04 \uace0\uc815\ud558\uace0 10,000~13,000rpm\uc5d0\uc11c 5\ubd84\uac04 \uc6d0\uc2ec\ubd84\ub9ac\ud558\uc5ec \uc218\uc9d1\ud588\uc2b5\ub2c8\ub2e4. \uc138\ud3ec\ub97c 3% \uae00\ub8e8\ud0c0\ub974\uc54c\ub370\ud788\ub4dc\ub85c 4\u00b0C\uc5d0\uc11c \ubc24\uc0c8 \ucd94\uac00\ub85c \uace0\uc815\ud55c \ub2e4\uc74c \uc2e4\uc628\uc5d0\uc11c 2\uc2dc\uac04 \ub3d9\uc548 1% \uc0ac\uc0b0\ud654\uc624\uc2a4\ubbb4\uc73c\ub85c \ucc98\ub9ac\ud588\uc2b5\ub2c8\ub2e4. \uadf8 \ud6c4, \uc0d8\ud50c\uc744 \uc544\uc138\ud1a4 \uad6c\ubc30\uc5d0\uc11c \ud0c8\uc218\uc2dc\ud0a4\uace0, Epon 812\uc5d0 \ub9e4\ub9bd\ud558\uace0, \uad11\ud559\uc801 \ud3ec\uc9c0\uc154\ub2dd\uc744 \uc2e4\uc2dc\ud558\uace0, \ucd08\ubc15\ud615 \ub2e8\uba74\uc73c\ub85c \uc808\ub2e8\ud558\uc600\ub2e4. \uc808\ud3b8\uc740 \uc6b0\ub77c\ub2d0 \uc544\uc138\ud14c\uc774\ud2b8\uc640 \ub0a9 \uad6c\uc5f0\uc0b0\uc5fc\uc73c\ub85c \uc774\uc911 \uc5fc\uc0c9\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ubbf8\uc138\uad6c\uc870\ub294 H-7650 \ud22c\uacfc\uc804\uc790\ud604\ubbf8\uacbd(Hitachi, Toyko, Japan)\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc870\uc0ac\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n<\/div>\n<div id=\"s2-6\" class=\"sec\">\n<h3 id=\"s2-6title\">\ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ud638\ud761\uc758 \uacb0\uc815<\/h3>\n<p class=\"p p-first-last\">\uc57d 10<sup>6<\/sup>\u00a0\uc138\ud3ec\ub97c \uc0ac\uc6a9\ud558\uc5ec O2K \ud638\ud761\uacc4(Oroboros Instruments, Austria)\ub97c \uc0ac\uc6a9\ud558\uc5ec \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ud638\ud761\uc744 \uce21\uc815\ud588\uc2b5\ub2c8\ub2e4. Oroboros DatLab 7.4 \uc18c\ud504\ud2b8\uc6e8\uc5b4\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc0b0\uc18c \ub18d\ub3c4\ub97c \uacb0\uc815\ud558\uace0 \ubd84\uc11d\ud588\uc2b5\ub2c8\ub2e4. \uac04\ub2e8\ud788 \ub9d0\ud574\uc11c, \ub204\ucd9c \ud638\ud761 \uc0c1\ud0dc\ub294 \uc138\ud3ec\uc5d0\uc11c\ub9cc \uae30\ub85d\ub418\uc5c8\uace0, \uc804\uc790 \uc804\ub2ec\uc740 5mM ADP\uc758 \ucca8\uac00\uc5d0 \uc758\ud55c \uc778\uc0b0\ud654\uc640 \uacb0\ud569\ub418\uc5c8\uc73c\uba70, \ubcf5\ud569\uccb4 I\uc5d0 \uc758\ud574 \uc9c0\uc6d0\ub418\ub294 \uc0c1\ud0dc 3 \ud638\ud761\uc774 \uae30\ub85d\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ubcf5\ud569\uccb4 I\uacfc \ubcf5\ud569\uccb4 II\uc758 \ubcd1\ub82c \uc804\uc790 \uc785\ub825\uc744 \ud1b5\ud55c \ucd5c\ub300 \uc0c1\ud0dc 3 \ud638\ud761\uc740 10mM \uc11d\uc2e0\uc0b0\uc5fc\uc758 \ucca8\uac00\ub97c \ud1b5\ud574 \uae30\ub85d\ub418\uc5c8\uc73c\uba70, \ubcf5\ud569\uccb4 II \uc9c0\uc6d0 \ud638\ud761\uc740 6.25\u03bcM \ub85c\ud14c\ub17c\uc758 \uc874\uc7ac \ud558\uc5d0\uc11c \uce21\uc815\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ucd5c\ub300 \uc804\uc790 \uc804\ub2ec \uc6a9\ub7c9\uc740 5 \u03bcM \uce74\ub974\ubcf4\ub2d0 \uc2dc\uc548\ud654\ubb3c p-(\ud2b8\ub9ac\ud50c\ub8e8\uc624\ub85c-\uba54\ud1a1\uc2dc) \ud398\ub2d0-\ud788\ub4dc\ub77c\uc874(FCCP) \uc874\uc7ac \ud558\uc5d0\uc11c \uae30\ub85d\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ub9c8\uc9c0\ub9c9\uc73c\ub85c \ubcf5\ud569\uccb4 \u2162\ub97c \uc644\uc131\ud558\uc5ec \ubaa8\ub4e0 \uc804\uc790\uc804\ub2ec\uc744 \ucc28\ub2e8\ud558\ub294 \ud56d\ub9c8\uc774\uc2e0(Ama)\uc744 \ud22c\uc5ec\ud558\uace0 \uc0b0\uc18c\uc18c\ubaa8\uc728\uc744 \ube44\ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uc0b0\uc18c\uc18c\ubaa8\ub7c9\uc73c\ub85c \uce21\uc815\ud558\uc600\ub2e4.<\/p>\n<\/div>\n<div id=\"s2-7\" class=\"sec\">\n<h3 id=\"s2-7title\">\ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ub9c9 \uc804\uc704(\u0394\u03a8m)\uc758 \ubcc0\ud654 \uacb0\uc815<\/h3>\n<p class=\"p p-first-last\">5.5&#039;,6.6&#039;-\ud14c\ud2b8\ub77c\ud074\ub85c\ub85c-1.1&#039;,3.3&#039;-\ud14c\ud2b8\ub77c\uc5d0\ud2f8\ubca4\uc988\uc774\ubbf8\ub2e4\uc878\ub9b4\uce74\ub974\ubcf4\uc2dc\uc544\ub2cc \uc694\uc624\ub2e4\uc774\ub4dc(JC-1) \uc5fc\uc0c9\uc744 \uc0ac\uc6a9\ud558\uc5ec H9c2 \uc138\ud3ec\uc758 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ub9c9 \uc804\uc704\ub97c \ud3c9\uac00\ud588\uc2b5\ub2c8\ub2e4. \uac04\ub2e8\ud788 \ub9d0\ud558\uba74, \ubbf8\ub9ac \uacb0\uc815\ub41c \uc2e4\ud5d8 \uc870\uac74\uc5d0 \ub530\ub77c H9c2 \uc138\ud3ec\ub97c \ub530\ub73b\ud55c Dulbecco \uc778\uc0b0\uc5fc \uc644\ucda9 \uc2dd\uc5fc\uc218(DPBS)\ub85c \uc138\ucc99\ud55c \ud6c4 100 \u03bcL\uc758 2 \u03bcM JC-1 \uc6a9\uc561(\ud398\ub180 \ub808\ub4dc\uac00 \uc5c6\ub294 DMEM\uc5d0 \ud63c\ud569)\uc73c\ub85c \uc5fc\uc0c9\ud558\uace0 \ud45c\uc900 \uc138\ud3ec \ubc30\uc591 \ud558\uc5d0\uc11c \ubc30\uc591\ud588\uc2b5\ub2c8\ub2e4. \uc5b4\ub460 \uc18d\uc5d0\uc11c 30\ubd84 \ub3d9\uc548\uc758 \uc870\uac74. \uc778\ud050\ubca0\uc774\uc158 \ud6c4, \uc138\ud3ec\ub97c \ub530\ub73b\ud55c DPBS\ub85c \uc138\ucc99\ud558\uace0, Leica Microsystems CMS GmbH \uc5ed\ud615\uad11 \ud604\ubbf8\uacbd(Leica Camera AG, Barnack, German)\uc744 \uc0ac\uc6a9\ud558\uc5ec 20\u00d7 \ubc30\uc728\ub85c \ud615\uad11 \ud604\ubbf8\uacbd\uc0ac\uc9c4\uc744 \ucc0d\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n<\/div>\n<div id=\"s2-8\" class=\"sec\">\n<h3 id=\"s2-8title\">\uba74\uc5ed\ud615\uad11<\/h3>\n<p class=\"p p-first-last\">\ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc704\uce58\ub97c \ud3c9\uac00\ud558\uae30 \uc704\ud574 \ucee4\ubc84\uc2ac\ub9bd\uc5d0\uc11c \uc131\uc7a5\ud55c \uc138\ud3ec\ub97c \ucc28\uac00\uc6b4 PBS\ub85c \uc138\ucc99\ud558\uace0 4% \ud30c\ub77c\ud3ec\ub984\uc54c\ub370\ud788\ub4dc\ub85c 15\ubd84 \ub3d9\uc548 \uace0\uc815\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub7f0 \ub2e4\uc74c \uc138\ud3ec\ub97c 0.5% Triton X-100\uc73c\ub85c 20\ubd84\uac04 \ud22c\uacfc\ud654\uc2dc\ud0a4\uace0 5% \uc5fc\uc18c \ud608\uccad\uc73c\ub85c 30\ubd84\uac04 \ucc28\ub2e8\ud588\uc2b5\ub2c8\ub2e4. \uc138\ud3ec\ub97c 4\u2103\uc5d0\uc11c \ubc24\uc0c8 1\ucc28 \ud56d\uccb4\uc640 \ud568\uaed8 \ubc30\uc591\ud558\uace0 1\uc2dc\uac04 \ub3d9\uc548 2\ucc28 \ud56d\uccb4\uc640 \ud568\uaed8 \ubc30\uc591\ud558\uc600\ub2e4. \uc138 \ubc88 \uc138\ucc99\ud55c \ud6c4 \uc138\ud3ec\ub97c 4&#039;-6-diamidino-2-phenylindole(DAPI)\ub85c \uc5fc\uc0c9\ud558\uace0 \uacf5\ucd08\uc810 \ub808\uc774\uc800 \uc2a4\uce90\ub2dd \ud604\ubbf8\uacbd\uc73c\ub85c \uc774\ubbf8\uc9c0\ud654\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<\/div>\n<div id=\"s2-9\" class=\"sec\">\n<h3 id=\"s2-9title\">ATP \uce21\uc815<\/h3>\n<p class=\"p p-first-last\">\ub610\ud55c, \uc138\ud3ec\ub0b4 ATP \ub18d\ub3c4\ub294 \uc81c\uc870\uc0ac\uc758 \ud504\ub85c\ud1a0\ucf5c\uc5d0 \ub530\ub77c ATP \ubd84\uc11d \ud0a4\ud2b8\ub97c \uc774\uc6a9\ud558\uc5ec \uce21\uc815\ud558\uc600\ub2e4. \ubc18\ubcf5\uc801\uc778 \ud53c\ud3ab\ud305\uc744 \ud1b5\ud574 \uc138\ud3ec\ub97c \uc6a9\ud574 \uc644\ucda9\uc561\uc5d0\uc11c \uc6a9\ud574\uc2dc\ud0a4\uace0 4\u00b0C, 13,000g\uc5d0\uc11c 10\ubd84\uac04 \uc6d0\uc2ec\ubd84\ub9ac\ud588\uc2b5\ub2c8\ub2e4. \uc0c1\ub4f1\uc561\uc740 ATP \uc218\uc900 \ubd84\uc11d\uc5d0 \uc0ac\uc6a9\ub418\uc5c8\uc73c\uba70 \ub2e8\ubc31\uc9c8 \ub18d\ub3c4\ub294 BCA \ubd84\uc11d\uc73c\ub85c \uacb0\uc815\ub418\uc5c8\uc2b5\ub2c8\ub2e4. 50 \ub9c8\uc774\ud06c\ub85c\ub9ac\ud130\uc758 \uc0c1\uccad\uc561\uc744 100 \u03bcl\uc758 ATP \uac80\ucd9c \uc6a9\uc561\uc5d0 \ucca8\uac00\ud558\uace0 \uc2e4\uc628\uc5d0\uc11c 5\ubd84 \ub3d9\uc548 \ubc30\uc591\ud55c \ud6c4 \uc989\uc2dc \ud63c\ud569\ud558\uace0 \ub8e8\ubbf8\ub178\ubbf8\ud130(Flex Station 3)\ub97c \uc0ac\uc6a9\ud558\uc5ec \ubc1c\uad11\uc131\uc744 \uce21\uc815\ud588\uc2b5\ub2c8\ub2e4. ATP\uc758 \ub18d\ub3c4\ub294 \ud45c\uc900 \uace1\uc120\uc5d0 \ub530\ub77c \uacc4\uc0b0\ub418\uc5c8\uc73c\uba70 nmol\/\u03bcg \ub2e8\ubc31\uc9c8\ub85c \ubcc0\ud658\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n<\/div>\n<div id=\"s2-10\" class=\"sec\">\n<h3 id=\"s2-10title\">\uc6e8\uc2a4\ud134 \ube14\ub85c\ud305<\/h3>\n<p class=\"p p-first-last\">\ub2e8\ubc31\uc9c8 \ubc1c\ud604\uc740 \uc6e8\uc2a4\ud134 \ube14\ub78f\uc73c\ub85c \ud3c9\uac00\ud558\uace0 \ub18d\ub3c4\uacc4\ub85c \uc815\ub7c9\ud654\ud588\uc2b5\ub2c8\ub2e4. 10cm \uc138\ud3ec \ubc30\uc591 \uc811\uc2dc\uc758 Dox \ubc0f Dox + Brev \ucc98\ub9ac H9c2 \uc138\ud3ec\ub97c RIPA \uc6a9\ud574 \uc644\ucda9\uc561\uc73c\ub85c \uc6a9\ud574\ud588\uc2b5\ub2c8\ub2e4. 5mg\uc758 \uc870\uc9c1\uc744 \ucc44\ucde8\ud558\uace0 10ml\uc758 \uc6a9\ud574 \uc644\ucda9\uc561\uc744 \ucd94\uac00\ud569\ub2c8\ub2e4. \ube0c\ub798\ub4dc\ud3ec\ub4dc(Bradford) \ubc29\ubc95\uc744 \uc0ac\uc6a9\ud558\uc5ec BSA\ub97c \ud45c\uc900\uc73c\ub85c \uc0ac\uc6a9\ud558\uc5ec \ub2e8\ubc31\uc9c8 \ub18d\ub3c4\ub97c \uce21\uc815\ud588\uc2b5\ub2c8\ub2e4. \ub3d9\uc77c\ud55c \uc591\uc758 \ub2e8\ubc31\uc9c8\uc744 \ub85c\ub529 \uc644\ucda9\uc561(5X)\uacfc \ud63c\ud569\ud558\uace0 95\u00b0C\uc5d0\uc11c 5\ubd84\uac04 \ub053\uc600\uc2b5\ub2c8\ub2e4. \uadf8\ub7f0 \ub2e4\uc74c \ub2e8\ubc31\uc9c8\uc744 10%-12% SDS-\ud3f4\ub9ac\uc544\ud06c\ub9b4\uc544\ubbf8\ub4dc \uac94(SDS-PAGE)\uc5d0\uc11c \uc804\uae30 \uc601\ub3d9\ud558\uc5ec \ubd84\ub9ac\ud558\uace0 PVDF \ub9c9\uc73c\ub85c \uc62e\uacbc\uc2b5\ub2c8\ub2e4. \uc2e4\uc628\uc5d0\uc11c 2\uc2dc\uac04 \ub3d9\uc548 TBST\uc5d0 \uc6a9\ud574\ub41c 5% \uc6b0\uc720\ub85c \ucc28\ub2e8\ud55c \ud6c4, \ub9c9\uc744 \ud1a0\ub07c \ub2e4\ud074\ub860 GAPDH\uc640 \uac19\uc740 \ud2b9\uc815 \ud56d\uccb4\uc640 \ud568\uaed8 4\u00b0C\uc5d0\uc11c \ubc24\uc0c8 \ubc30\uc591\ud588\uc2b5\ub2c8\ub2e4. \ub2e8\ubc31\uc9c8 \ubc1c\ud604 \ubc0f \uc778\uc0b0\ud654\uc5d0 \ub300\ud55c WB \ubd84\uc11d\uc740 AMPK, Parkin, PINK1, Akt, PI3K, Tom20\uc5d0 \ub300\ud55c \ud56d\uccb4\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc218\ud589\ub418\uc5c8\uc73c\uba70 GAPDH\ub294 \ub0b4\ubd80 \ub300\uc870\uad70\uc73c\ub85c \uc0ac\uc6a9\ub418\uc5c8\uc2b5\ub2c8\ub2e4. Bio-Rad gel doc \uc2dc\uc2a4\ud15c(Bio-Rad Laboratories, California, United States)\uc744 \uc0ac\uc6a9\ud558\uc5ec \ud2b9\uc815 \uc2e0\ud638\ub97c \uc2dc\uac01\ud654\ud588\uc2b5\ub2c8\ub2e4. \ub370\uc774\ud130\ub294 \ud3c9\uade0 \u00b1 SD(<em>N<\/em>\u00a0= 3) ImageJ \ubd84\uc11d\uc73c\ub85c \uc815\ub7c9\ud654\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n<\/div>\n<div id=\"s2-11\" class=\"sec\">\n<h3 id=\"s2-11title\">\ucd95\uc0b0<\/h3>\n<p class=\"p p-first\">8\uc8fc\ub839 \uc554\ucef7 C57BL\/6 \ub9c8\uc6b0\uc2a4(SiPeiFu, Beijing, China)\ub97c \uc2e4\ud5d8\uc5d0 \uc0ac\uc6a9\ud588\uc2b5\ub2c8\ub2e4. \ub3d9\ubb3c\uc744 \uc6b0\ub9ac\uc5d0 \ub123\uace0 50% \uc2b5\ub3c4 \ubc0f 25\u00b0C \u00b1 2\u00b0C\uc5d0\uc11c 12\uc2dc\uac04 \uba85\/12\uc2dc\uac04 \uc554\uc8fc\uae30\ub85c \uc0ac\uc721\ud588\uc2b5\ub2c8\ub2e4. \ub3d9\ubb3c\uc5d0\uac8c \ud45c\uc900 \ud3a0\ub9bf \uc0ac\ub8cc\uc640 \ubb3c\uc744 \uc790\uc720\ub86d\uac8c \uc81c\uacf5\ud588\uc2b5\ub2c8\ub2e4. \ud608\uc7a5\uc740 200g\uc5d0\uc11c 10\ubd84 \ub3d9\uc548 4\u00b0C\uc5d0\uc11c \uc6d0\uc2ec\ubd84\ub9ac\ud558\uc5ec \uc5bb\uc5c8\uace0 \ucd94\ucd9c \uc804\uc5d0 -80\u00b0C\uc5d0\uc11c \ubcf4\uad00\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p class=\"p p-last\">\uc870\uc0ac\ub294 \ub2e4\uc74c \uc0ac\ud56d\uc5d0 \ubd80\ud569\ud569\ub2c8\ub2e4.\u00a0<em>\uc2e4\ud5d8\uc2e4 \ub3d9\ubb3c\uc758 \uad00\ub9ac \ubc0f \uc0ac\uc6a9 \uc9c0\uce68<\/em>\u00a0\ubbf8\uad6d \uad6d\ub9bd\ubcf4\uac74\uc6d0(NIH Publication No. 85-23, 1985\ub144 \uac1c\uc815)\uc5d0\uc11c \ucd9c\ud310\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n<\/div>\n<div id=\"s2-12\" class=\"sec\">\n<h3 id=\"s2-12title\">\ub3d9\ubb3c \uc2e4\ud5d8 \ud504\ub85c\ud1a0\ucf5c<\/h3>\n<p class=\"p p-first\">\ub9c8\uc6b0\uc2a4\ub97c \ub300\uc870\uad70, \ubaa8\ub378 \uadf8\ub8f9(Dox \uadf8\ub8f9), 3\uac1c \uc6a9\ub7c9\uc758 Dox + Brev \uadf8\ub8f9 \ubc0f Dox + Dexra \uadf8\ub8f9\uc744 \ud3ec\ud568\ud558\uc5ec 6\uac1c\uc758 \uce58\ub8cc \uadf8\ub8f9\uc5d0 \ubb34\uc791\uc704\ub85c \ud560\ub2f9\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\uc778\uac04 \uce58\ub8cc \uc694\ubc95\uc744 \ubaa8\ubc29\ud558\uae30 \uc704\ud574 \ub204\uc801 \uc6a9\ub7c9 12mg\/kg\uc758 Dox\ub97c \ud22c\uc5ec\ud588\uc2b5\ub2c8\ub2e4.\u00a0<em>~\uc744 \ud1b5\ud574<\/em>\u00a0\ub300\uc870\uad70\uc744 \uc81c\uc678\ud558\uace0 \ub9e4\uc8fc 3\ud68c \ubcf5\uac15\ub0b4 \uc8fc\uc0ac(0\uc77c, 7\uc77c, 14\uc77c\uc5d0 4mg\/kg).<\/p>\n<p>Brev\uc758 \ud6a8\uacfc\ub97c \uc870\uc0ac\ud558\ub824\uba74\u00a0<em>\uc0dd\uccb4 \ub0b4\uc5d0\uc11c,<\/em>\u00a0\ub9c8\uc6b0\uc2a4\uc5d0 Brev\ub97c \ud22c\uc5ec\ud55c \ud6c4 \ub9e4\uc77c Brev 4.8\uc744 \ubcf5\uac15\ub0b4 \uc8fc\uc0ac\ud558\uace0 Brev\ub97c 16 mg\/kg\uc744 3\uc8fc \ub3d9\uc548 \ud22c\uc5ec\ud558\uc600\uc73c\uba70, Dox + Dexra \uce58\ub8cc\uad70 \ub9c8\uc6b0\uc2a4\uc5d0\ub294 Dox \uc678\uc5d0 12 mg\/kg Dexra\ub97c 3\uc8fc \ub3d9\uc548 \ubcf5\uac15\ub0b4 \uc8fc\uc0ac\ub85c \ud22c\uc5ec\ud558\uc600\ub2e4. \uce58\ub8cc. (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B1\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc54c\ub809\uc0c1\ub4dc\ub974 \uc678, 2020<\/a>). Brev\uc640 Dexra\ub294 Dox \uc8fc\uc0ac \ud6c4 \uce58\ub8cc\ub97c \ubc1b\uc558\uc2b5\ub2c8\ub2e4. Dox\ub97c \ucc98\uc74c \uc8fc\uc0ac\ud55c \ud6c4 3\uc8fc \ud6c4\uc5d0 \uc0dd\uc874 \uc5ec\ubd80\ub97c \ub9e4\uc77c \ubaa8\ub2c8\ud130\ub9c1\ud558\uace0 \uc2ec\uc7a5\ucd08\uc74c\ud30c \uac80\uc0ac\ub97c \ud1b5\ud574 \uc2ec\uc7a5 \uae30\ub2a5\uc744 \ud3c9\uac00\ud588\uc2b5\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B21\" aria-expanded=\"false\" aria-haspopup=\"true\">\ub9ac \uc678, 2018<\/a>).<\/p>\n<p class=\"p p-last\">\ub300\uc870\uad70\uc5d0\ub294 \uac19\uc740 \uc591\uc758 \uc0dd\ub9ac\uc2dd\uc5fc\uc218\ub97c \uc8fc\uc0ac\ud558\uc600\ub2e4. Dox \ud22c\uc5ec 1\uc8fc\uc77c \ud6c4 \ub9c8\uc6b0\uc2a4\ub97c \ud76c\uc0dd\uc2dc\ucf30\ub2e4.<\/p>\n<\/div>\n<div id=\"s2-13\" class=\"sec\">\n<h3 id=\"s2-13title\">\uc885\uc591 \uc5f0\uad6c<\/h3>\n<p class=\"p p-first-last\">\ub9c8\uc6b0\uc2a4\uc5d0\uac8c 1\u00d710<sup>5<\/sup>\u00a04T1 \uc720\ubc29 \uc885\uc591 \uc138\ud3ec. \uc138\ud3ec \uc8fc\uc785 1\uc8fc\uc77c \ud6c4 \uc885\uc591\uc758 \ud3c9\uade0 \uc9c1\uacbd\uc774 2mm\ubcf4\ub2e4 \ud074 \ub54c \uc774\uc804\uc5d0 \uc124\uba85\ud55c \ub300\ub85c \ub9c8\uc6b0\uc2a4\ub97c Dox \ub610\ub294 \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc73c\ub85c \uce58\ub8cc\ud588\uc2b5\ub2c8\ub2e4. \uc885\uc591 \ud06c\uae30\ub294 \ucd5c\ub300 4\uc8fc \ub3d9\uc548 \uc77c\uc8fc\uc77c\uc5d0 2\ubc88 \uce21\uc815\ub418\uc5c8\uc73c\uba70, \uc885\uc591 \ubd80\ud53c\ub294 \ub2e4\uc74c \ubc29\uc815\uc2dd\uc73c\ub85c \uacc4\uc0b0\ub418\uc5c8\uc2b5\ub2c8\ub2e4: V = 4\u03c0\/3\u00d7(L\/2)2\u00d7 (W\/2), \uc5ec\uae30\uc11c V, L \ubc0f W\ub294 \uc885\uc591\uc758 \ubd80\ud53c, \uae38\uc774 \ubc0f \ub108\ube44.<\/p>\n<\/div>\n<div id=\"s2-14\" class=\"sec\">\n<h3 id=\"s2-14title\"><sup>18<\/sup>F-\ud50c\ub8e8\uc624\ub85c\ub370\uc625\uc2dc\uae00\ub8e8\ucf54\uc2a4 PET\/CT \uc601\uc0c1<\/h3>\n<p class=\"p p-first-last\">Dox \ubc0f \ube0c\ub808\ube44\uc2a4\uce74\ud540 \uadf8\ub8f9 \ub9c8\uc6b0\uc2a4(\ubc24\uc0c8 \uae08\uc2dd)\ub97c 2% \uc774\uc18c\ud50c\ub8e8\ub780\uc73c\ub85c \ub9c8\ucde8\ud558\uace0 ~11MBq\/0.2ml\uc758 \ud50c\ub8e8\uc624\ub85c\ub370\uc625\uc2dc\uae00\ub8e8\ucf54\uc2a4(FDG) PET\ub97c \uc8fc\uc0ac\ud588\uc2b5\ub2c8\ub2e4.\u00a0<em>~\uc744 \ud1b5\ud574<\/em>\u00a0\uaf2c\ub9ac \uc815\ub9e5\uc744 \uc81c\uac70\ud55c \ud6c4 \uc6b0\ub9ac\ub85c \ub3cc\uc544\uac14\uc2b5\ub2c8\ub2e4. 40\ubd84 \ud6c4, \ub9c8\uc6b0\uc2a4\ub97c 2% \uc774\uc18c\ud50c\ub8e8\ub780\uc73c\ub85c \ub2e4\uc2dc \ub9c8\ucde8\uc2dc\ud0a4\uace0 microPET Focus 220(Siemens Company, Berlin, Germany)\uc758 \uc815\uc704 \uce68\ub300\uc5d0 \ubc30\uce58\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub7f0 \ub2e4\uc74c 20\ubd84 \uc815\uc801 PET \uc2a4\uce94\uc774 \uc2dc\uc791\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uadf8 \ud6c4, PET \uc601\uc0c1\uacfc\uc758 \ud574\ubd80\ud559\uc801 \uacf5\ub3d9 \ub4f1\ub85d\uc744 \uc704\ud574 180mAs\uc758 X\uc120 \ube54 \uac15\ub3c4\uc640 80kVp\uc758 X\uc120\uad00 \uc804\uc555\uc73c\ub85c microCAT II(\ub3c5\uc77c \ubca0\ub97c\ub9b0 \uc18c\uc7ac Siemens Company)\uc5d0\uc11c \ub9c8\uc6b0\uc2a4\ub97c \uc601\uc0c1\ud654\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<\/div>\n<div id=\"s2-15\" class=\"sec\">\n<h3 id=\"s2-15title\">\ud658\uc790<\/h3>\n<p class=\"p p-first-last\">4\uc2dc\uac04 \uc774\uc0c1\uc758 \uae08\uc2dd \ud6c4 \ud608\ub2f9 \uc218\uce58\ub97c 120mg\/dl \ubbf8\ub9cc\uc73c\ub85c \uc720\uc9c0\ud55c \ud6c4 \ubaa8\ub4e0 \ud658\uc790\uc5d0\uac8c \uc774 \uc57d\uc744 \uc815\ub9e5 \ud22c\uc5ec\ud588\uc2b5\ub2c8\ub2e4.\u00a0<sup>18<\/sup>F-FDG(5.5MBq\/kg). PET\/CT \uc2a4\uce94\uc740 \uacb0\ud569\ub41c PET\/CT \uc804\uae30(Siemens Company, Berlin, Germany)\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc8fc\uc0ac \ud6c4 60\ubd84\uc5d0 \uc2dc\uc791\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ubaa8\ub4e0 \uc2a4\uce94\uc740 3\ucc28\uc6d0 \ubaa8\ub378\uc5d0\uc11c \uc218\ud589\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uac10\uc1e0 \uad50\uc815 \ubc0f \ud574\ubd80\ud559\uc801 \uc0c1\uad00\uad00\uacc4\ub97c \ud655\uc778\ud558\uae30 \uc704\ud574 \uba3c\uc800 \uc800\uc120\ub7c9 CT \uc2a4\uce94\uc744 \ud68d\ub4dd\ud588\uc2b5\ub2c8\ub2e4. \uc724\ub9ac\uc801 \ud5c8\uac00\ub294 \uce6d\ub2e4\uc624\ub300\ud559\uad50 \ubd80\uc18d\ubcd1\uc6d0\uc5d0\uc11c \ubc1c\ud589\ud55c \uc724\ub9ac\uc704\uc6d0\ud68c \uc2b9\uc778 \ubb38\uc11c \uc9c0\uce68(QDU-HEC-2022057)\uc744 \uc900\uc218\ud569\ub2c8\ub2e4.<\/p>\n<\/div>\n<div id=\"s2-16\" class=\"sec\">\n<h3 id=\"s2-16title\">\uc2ec\uc7a5 \uae30\ub2a5 \ubc0f \uc870\uc9c1 \ubcd1\ub9ac\ud559 \ubd84\uc11d<\/h3>\n<p class=\"p p-first-last\">\uac01 \uadf8\ub8f9\uc758 \ub9c8\uc6b0\uc2a4 \uc2ec\uc7a5 \uc870\uc9c1\uc744 4% \ud30c\ub77c\ud3ec\ub984\uc54c\ub370\ud788\ub4dc\uc5d0 \ubcf4\uad00\ud558\uace0 \ud30c\ub77c\ud540 \uc641\uc2a4\uc5d0 \ubb3b\ud600\uc11c 4mm \uc139\uc158\uc73c\ub85c \uc5f0\uc18d\uc801\uc73c\ub85c \uc808\ub2e8\ud588\uc2b5\ub2c8\ub2e4. \uc870\uc9c1 \uc139\uc158\uc740 \ud30c\ub77c\ud540 \uc81c\uac70\ub418\uc5c8\uc2b5\ub2c8\ub2e4\u00a0<em>~\uc744 \ud1b5\ud574<\/em>\u00a0\uc790\uc77c\ub80c\uc5d0 \ub2f4\uadf8\uace0(\uac01\uac01 5\ubd84 \ub3d9\uc548 3\ud68c) \ud558\uac15\ud558\ub294 \uc77c\ub828\uc758 \uc54c\ucf54\uc62c(100%, 90%, 85% \ubc0f 75% \uc54c\ucf54\uc62c, \uac01 5\ubd84)\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc7ac\uc218\ud654\ud569\ub2c8\ub2e4. \uc870\uc9c1\ud559\uc801 \ubd84\uc11d\uc744 \uc704\ud574 \uc808\ud3b8\uc744 \ud5e4\ub9c8\ud1a1\uc2e4\ub9b0\uacfc \uc5d0\uc624\uc2e0\uc73c\ub85c \uc5fc\uc0c9\ud588\uc2b5\ub2c8\ub2e4. \uc2ec\uc7a5\uc758 \ud615\ud0dc\ud559\uc801 \ubc0f \uc12c\uc720\uc131 \ubcc0\ud654\ub97c \uc870\uc0ac\ud558\uae30 \uc704\ud574 \uc0dd\uac80 \uc0d8\ud50c\uc744 Masson\uc758 \uc0bc\uc0c9 \uc5fc\uc0c9\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc5fc\uc0c9\ud588\uc2b5\ub2c8\ub2e4. \ud30c\ub780\uc0c9 \uc5fc\uc0c9\uc740 \ucf5c\ub77c\uac90 \ucd95\uc801\uc744 \ub098\ud0c0\ub0c5\ub2c8\ub2e4. \uba74\uc5ed\uc870\uc9c1\ud654\ud559\uc740 \uc81c\uc870\uc5c5\uccb4\uc758 \uc9c0\uce68\uc5d0 \ub530\ub77c Histone Simple \uc5fc\uc0c9 \ud0a4\ud2b8(Nichirei, Tokyo, Japan)\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc218\ud589\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc808\ud3b8\uc744 \uba54\ud0c4\uc62c \uc911 3% H2O2\ub85c 15\ubd84 \ub3d9\uc548 \ucc98\ub9ac\ud558\uc5ec \ub0b4\uc778\uc131 \ud37c\uc625\uc2dc\ub2e4\uc81c\ub97c \ubd88\ud65c\uc131\ud654\uc2dc\ud0a8 \ub2e4\uc74c \uc2e4\uc628\uc5d0\uc11c 1\ucc28 \ud56d\uccb4 IL-1, 1:100\uacfc \ud568\uaed8 1\uc2dc\uac04 \ub3d9\uc548 \ubc30\uc591\ud588\uc2b5\ub2c8\ub2e4. \uc774\uc5b4\uc11c, Leica Microsystems&#039; CMS GmbH \uc5ed\ud615\uad11 \ud604\ubbf8\uacbd(Leica Camera AG, Barnack, Germany)\uc744 \uc0ac\uc6a9\ud558\uc5ec \ucd08\ubbf8\uc138\uad6c\uc870\ub97c 20\u00d7 \ubc30\uc728\ub85c \uad00\ucc30\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<\/div>\n<div id=\"s2-17\" class=\"sec\">\n<h3 id=\"s2-17title\">\ud3ec\ub3c4\ub2f9 \uc218\uc900 \uce21\uc815<\/h3>\n<p class=\"p p-first\">\uc0dd\uc950\ub294 \uc815\uc0c1\uc801\uc778 \uc74c\uc2dd\uc744 \uba39\ub3c4\ub85d \uc720\uc9c0\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc2e4\ud5d8 \ub2f9\uc77c \uc950\ub97c 6\uc2dc\uac04 \ub3d9\uc548(\uc624\uc804 8\uc2dc\ubd80\ud130) \uae08\uc2dd\uc2dc\ud0a8 \ud6c4 \ud608\uc561\uc744 \ucc44\ucde8\ud558\uc600\ub2e4.\u00a0<em>~\uc744 \ud1b5\ud574<\/em>\u00a0\ud3ec\ub3c4\ub2f9 \uc218\uce58 \uce21\uc815\uc744 \uc704\ud55c \uaf2c\ub9ac \uc815\ub9e5.<\/p>\n<p class=\"p p-last\">H9c2 \ub798\ud2b8 \uc2ec\uadfc\uc544\uc138\ud3ec\ub97c \uc778\uc0b0\uc5fc \uc644\ucda9 \uc2dd\uc5fc\uc218(PBS)\ub85c \uc138\ucc99\ud558\uace0 \uc6d0\uc2ec\ubd84\ub9ac\ud558\uace0 \ucd08\uc74c\ud30c\ub85c \ubd84\uc1c4\ud55c \ud6c4 \ud45c\uc900 \uc138\ud3ec \ubc30\uc591 \uc870\uac74\uc5d0\uc11c 10\ubd84\uac04 \ubc30\uc591\ud588\uc2b5\ub2c8\ub2e4. \uc778\ud050\ubca0\uc774\uc158 \ud6c4, \ub9c8\uc774\ud06c\ub85c\ud50c\ub808\uc774\ud2b8 \ud310\ub3c5\uae30(Perkin Elmer, Massachusetts, United States)\ub97c \uc0ac\uc6a9\ud558\uc5ec \ud761\uad11\ub3c4\ub97c \uce21\uc815\ud558\uc600\ub2e4.<\/p>\n<\/div>\n<div id=\"s2-18\" class=\"sec\">\n<h3 id=\"s2-18title\">\ud6a8\uc18c \uba74\uc5ed \ubd84\uc11d\ubc95<\/h3>\n<p class=\"p p-first-last\">\ub9c8\uc6b0\uc2a4 \uc870\uc9c1\uc744 \uc6a9\ud574 \uc644\ucda9\uc561\uc73c\ub85c \uc6a9\ud574\uc2dc\ucf30\ub2e4. \uc0d8\ud50c\uc744 20\ucd08 \ub3d9\uc548 30Hz \ud384\uc2a4\ub97c \uc0ac\uc6a9\ud558\uc5ec Qsonica \uade0\uc9c8\ud654\uae30\ub85c \ucd08\uc74c\ud30c \ucc98\ub9ac\ud55c \ud6c4 10\ubd84 \ub3d9\uc548 12,000g\uc5d0\uc11c \uc6d0\uc2ec\ubd84\ub9ac\ud588\uc2b5\ub2c8\ub2e4. \uc0c1\uccad\uc561\uc744 \uc218\uc9d1\ud558\uace0 200\u03bcl \ubc14\uc774\uc54c\uc5d0 \ubd84\ucde8\ud55c \ud6c4 -80\u00b0C\uc5d0\uc11c \ubcf4\uad00\ud588\uc2b5\ub2c8\ub2e4. \uc0d8\ud50c\uc758 \ub2e8\ubc31\uc9c8 \ub18d\ub3c4\ub294 BCA \ubd84\uc11d\uc73c\ub85c \uc815\ub7c9\ud654\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc0d8\ud50c\uc740 \uc81c\uc870\uc5c5\uccb4\uc758 \ud504\ub85c\ud1a0\ucf5c\uc5d0 \ub530\ub77c TNF-\u03b1, IL-1\u03b2 \ubc0f IL-6\uc5d0 \ub300\ud55c \ud6a8\uc18c \uacb0\ud569 \uba74\uc5ed\ud761\ucc29 \ubd84\uc11d \ud0a4\ud2b8\ub97c \uc0ac\uc6a9\ud558\uc5ec \ubd84\uc11d\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uad11\ud559 \ubc00\ub3c4\ub294 VICTOR Nivo\u2122 \ub9c8\uc774\ud06c\ub85c\ud50c\ub808\uc774\ud2b8 \ud310\ub3c5\uae30(Perkin Elmer, Massachusetts, United States)\ub97c \uc0ac\uc6a9\ud558\uc5ec 450 nm\uc5d0\uc11c \uce21\uc815\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n<\/div>\n<div id=\"s2-19\" class=\"sec\">\n<h3 id=\"s2-19title\">\ub9c8\uc6b0\uc2a4 \ub300\uc0ac\uccb4\uc758 \ubcc0\ud654 \uacb0\uc815<\/h3>\n<p class=\"p p-first-last\">\ud608\uc561 \uc0d8\ud50c\uc744 \uc7ac\ud604\ud0c1\uc2dc\ud0a4\uace0, \uc5bc\uc74c \uc704\uc5d0\uc11c \ubc30\uc591\ud558\uace0, \uc6d0\uc2ec\ubd84\ub9ac\ud558\uace0, \ucd5c\uc885 \ub18d\ub3c4\ub85c \ud76c\uc11d\ud558\uace0, \uc6d0\uc2ec\ubd84\ub9ac\ud588\uc2b5\ub2c8\ub2e4. \ub9c8\uc9c0\ub9c9\uc73c\ub85c \ubd84\uc11d\uc744 \uc704\ud574 \uc0c1\uccad\uc561\uc744 LC-MS\/MS \uc2dc\uc2a4\ud15c\uc5d0 \uc8fc\uc785\ud588\uc2b5\ub2c8\ub2e4. UHPLC-MS\/MS \ubd84\uc11d\uc740 Orbitrap Q Exactive\uc640 \uacb0\ud569\ub41c Vanquish UHPLC \uc2dc\uc2a4\ud15c(Thermo Fisher, Massachusetts, United States)\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc218\ud589\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<sup>TM<\/sup>\u00a0HF \uc9c8\ub7c9 \ubd84\uc11d\uae30(\ubbf8\uad6d \ub9e4\uc0ac\ucd94\uc138\uce20\uc8fc Thermo Fisher). \uc2dd\ubcc4\ub41c \ub300\uc0ac\uc0b0\ubb3c\uc740 KEGG \ub370\uc774\ud130\ubca0\uc774\uc2a4, HMDB \ub370\uc774\ud130\ubca0\uc774\uc2a4 \ubc0f LIPID Maps \ub370\uc774\ud130\ubca0\uc774\uc2a4\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc8fc\uc11d\uc744 \ub2ec\uc558\uc2b5\ub2c8\ub2e4. \uc8fc\uc131\ubd84 \ubd84\uc11d(PCA)\uacfc \ubd80\ubd84 \ucd5c\uc18c \uc81c\uacf1 \ud310\ubcc4 \ubd84\uc11d(PLS-DA)\uc740 MetaX\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc218\ud589\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc6b0\ub9ac\ub294 \ub2e8\ubcc0\ub7c9 \ubd84\uc11d(<em>\ud2f0<\/em>-\ud14c\uc2a4\ud2b8)\ub97c \ud1b5\ud574 \ud1b5\uacc4\uc801 \uc720\uc758\uc131\uc744 \uacc4\uc0b0\ud569\ub2c8\ub2e4(<em>\ud53c<\/em>-\uac12). VIP\uac00 \uc788\ub294 \ub300\uc0ac\ubb3c\uc9c8&gt;1,\u00a0<em>\ud53c<\/em>\u00a0\uac12\uc774 0.05 \ubbf8\ub9cc\uc774\uace0 \ubc30\uc218 \ubcc0\ud654\uac00 2 \uc774\uc0c1 \ub610\ub294 0.5 \uc774\ud558\uc774\uba74 \ucc28\ubcc4\uc801\uc73c\ub85c \ud48d\ubd80\ud55c \ub300\uc0ac \uc0b0\ubb3c\ub85c \uac04\uc8fc\ub429\ub2c8\ub2e4.<\/p>\n<\/div>\n<div id=\"s2-20\" class=\"sec sec-last\">\n<h3 id=\"s2-20title\">\ud1b5\uacc4 \ubd84\uc11d<\/h3>\n<p class=\"p p-first-last\">\ud1b5\uacc4 \ubd84\uc11d\uc740 IBM SPSS Statistics(V19.0, America)\uc640 \ud568\uaed8 ANOVA\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc218\ud589\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ub370\uc774\ud130\ub294 \ud3c9\uade0 \u00b1 SD(<em>N<\/em>\u00a0= 6\u20139).\u00a0<em>\ud53c<\/em>\u00a0&lt;0.05\ub294 \uc720\uc758\ubbf8\ud55c \uac83\uc73c\ub85c \uac04\uc8fc\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n<\/div>\n<\/div>\n<div id=\"s3\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\uc774 \ud398\uc774\uc9c0\uc758 \ub2e4\ub978 \uc139\uc158\uc73c\ub85c \uc774\ub3d9\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc774\ub3d9 :<\/a><\/div>\n<h2 id=\"s3title\" class=\"head no_bottom_margin ui-helper-clearfix\">\uacb0\uacfc<\/h2>\n<div id=\"s3-1\" class=\"sec sec-first\">\n<h3 id=\"s3-1title\">\uc548\ud2b8\ub77c\uc0ac\uc774\ud074\ub9b0\uc740 \uc2ec\uadfc\uc758 \ud3ec\ub3c4\ub2f9 \ub300\uc0ac\ub97c \uac10\uc18c\uc2dc\ud0a4\uace0 \uc9c0\ubc29\uc0b0 \ud65c\uc6a9\uc744 \uc99d\uac00\uc2dc\ud0b5\ub2c8\ub2e4.<\/h3>\n<p class=\"p p-first\">\uc6b0\ub9ac\ub294 \ucc98\uc74c\uc5d0 \uacf5\ubd80\ud588\uc2b5\ub2c8\ub2e4.\u00a0<sup>18<\/sup>\uc548\ud2b8\ub77c\uc0ac\uc774\ud074\ub9b0 \ud654\ud559\uc694\ubc95\uc744 \ubc1b\uc740 \ud658\uc790\uc640 \ud654\ud559\uc694\ubc95\uc744 \ubc1b\uc9c0 \uc54a\uc740 \ud658\uc790\uc758 \uc2ec\uc7a5\uc5d0 \ub300\ud55c F-FDG PET\/CT \uc601\uc0c1\uacfc \ub370\uc774\ud130 \ubd84\uc11d \uacb0\uacfc(<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F1\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 1A<\/a>) \ud654\ud559\uc694\ubc95\uc73c\ub85c \uce58\ub8cc\ubc1b\uc740 \ud658\uc790\uc758 \uc2ec\uadfc \ud3ec\ub3c4\ub2f9 \ud761\uc218\uac00 \uac10\uc18c\ud558\ub294 \uacbd\ud5a5. \uc6b0\ub9ac\ub294 \uc774 \ub9e4\uac1c\ubcc0\uc218\uc758 \ubcc0\ud654\uac00 \uc548\ud2b8\ub77c\uc0ac\uc774\ud074\ub9b0 \uc720\ubc1c \uc2ec\uc7a5\ub3c5\uc131\uacfc \uc0c1\uad00\uad00\uacc4\uac00 \uc788\uc744 \uc218 \uc788\ub2e4\uace0 \uc608\uce21\ud588\uc2b5\ub2c8\ub2e4. \ub300\uc0ac \uc774\uc0c1\uacfc DIC \uc0ac\uc774\uc758 \ubcf8\uc9c8\uc801\uc778 \uc5f0\uad00\uc131\uc744 \ud655\uc778\ud558\uae30 \uc704\ud574 \uc6b0\ub9ac\ub294 Dox \uc720\ub3c4 DIC \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc744 \ud655\ub9bd\ud588\uc73c\uba70\u00a0<sup>18<\/sup>F-FDG PET \uacb0\uacfc\ub294 4\uc8fc \ud6c4\uc5d0 Dox\ub97c \ud22c\uc5ec\ud55c \ub9c8\uc6b0\uc2a4\uc5d0\uc11c \uce58\ub8cc\ub97c \ubc1b\uc9c0 \uc54a\uc740 \ub9c8\uc6b0\uc2a4\uc5d0 \ube44\ud574 \uc2ec\uc7a5 \ud761\uc218\uac00 \ud604\uc800\ud788 \ub0ae\uc740 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F1\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 1B<\/a>). \uc774\ub294 \uc548\ud2b8\ub77c\uc0ac\uc774\ud074\ub9b0\uc774 \ud658\uc790\uc640 \ub9c8\uc6b0\uc2a4 \ubaa8\ub378 \ubaa8\ub450\uc5d0\uc11c \uc2ec\uadfc \ud3ec\ub3c4\ub2f9 \ub300\uc0ac\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce5c\ub2e4\ub294 \uac83\uc744 \uc758\ubbf8\ud569\ub2c8\ub2e4.<\/p>\n<div id=\"F1\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm139983198938400\">\n<div class=\"ts_bar small\" title=\"\ud655\ub300\ud558\ub824\uba74 \uc774\ubbf8\uc9c0\ub97c \ud074\ub9ad\ud558\uc138\uc694.\"><\/div>\n<p><a class=\"inline_block ts_canvas\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/core\/lw\/2.0\/html\/tileshop_pmc\/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&amp;p=PMC3&amp;id=9551275_fphar-13-930835-g001.jpg\" target=\"tileshopwindow\" rel=\"noopener\"><img decoding=\"async\" class=\"tileshop\" title=\"\ud655\ub300\ud558\ub824\uba74 \uc774\ubbf8\uc9c0\ub97c \ud074\ub9ad\ud558\uc138\uc694.\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/bin\/fphar-13-930835-g001.jpg\" alt=\"An external file that holds a picture, illustration, etc.Object name is fphar-13-930835-g001.jpg\" \/><\/a><\/div>\n<div id=\"lgnd_F1\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F1\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 1<\/a><\/div>\n<div class=\"caption\">\n<p><strong>(\u314f)<\/strong>\u00a0\ub18d\ub3c4\u00a0<sup>18<\/sup>F-FDG\ub294 \ud654\ud559\uc694\ubc95 \uce58\ub8cc\ub97c \ubc1b\uc740 \ud658\uc790\uc640 \ud654\ud559\uc694\ubc95\uc744 \ubc1b\uc9c0 \uc54a\uc740 \ud658\uc790\uc758 \uc2ec\uc7a5\uc5d0 \ud761\uc218\ub429\ub2c8\ub2e4.\u00a0<strong>(\ube44)<\/strong>\u00a0<sup>18<\/sup>F-FDG PET\/CT \uc601\uc0c1 \ud68d\ub4dd \ubc0f \uc2ec\uc7a5\u00a0<sup>18<\/sup>F-FDG \ud761\uc218.\u00a0<strong>(\uc528)<\/strong>\u00a0Dox \ucc98\ub9ac\ub41c \ub9c8\uc6b0\uc2a4\uc758 \ud788\ud2b8 \ub9f5.\u00a0<strong>(\ub514)<\/strong>\u00a0H9c2 \uc138\ud3ec\uc758 MDA \ud568\ub7c9.\u00a0<strong>(\uc774\uc790\ud615)<\/strong>\u00a0HE \uc5fc\uc0c9\uc740 Dox\uac00 \uc2ec\uadfc\uc138\ud3ec \ud06c\uae30\ub97c \uac10\uc18c\uc2dc\ucf30\uc74c\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4. \ucee8\ud2b8\ub864 \ub300 Dox: ***<em>\ud53c<\/em>\u00a0&lt; 0.0005, **<em>\ud53c<\/em>\u00a0&lt; 0.005, *<em>\ud53c<\/em>\u00a0&lt; 0.05, \ud3c9\uade0 \u00b1 SD.\u00a0<em>N<\/em>\u00a0= 6\u20139.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p class=\"p p-last\">\uc815\uc0c1\uc801\uc778 \uc870\uac74\uc5d0\uc11c \uc2ec\uadfc\uc740 \uc8fc\ub85c \uc5d0\ub108\uc9c0 \uacf5\uae09\uc744 \uc704\ud574 \ub2f9\uacfc \uc9c0\uc9c8\uc744 \uc0ac\uc6a9\ud558\uba70 \ub2f9\uacfc \uc9c0\uc9c8\uc740 \uac01\uac01 \uc57d 20%~30% \ubc0f 60%\uc758 \uc2ec\uadfc \uc5d0\ub108\uc9c0\ub97c \ucc28\uc9c0\ud569\ub2c8\ub2e4. \uac8c\ub2e4\uac00 \ud3ec\ub3c4\ub2f9\uc740 ATP \uc0dd\uc0b0\uc5d0 \ub354 \ud6a8\uc728\uc801\uc785\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B39\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc0e4\uc624\uc640 \ud2f0\uc548, 2015<\/a>). \uc2ec\uc7a5\uc774 \ud654\ud559\uc694\ubc95\uc5d0 \uc758\ud55c \uc2ec\uadfc\uc758 \uc5d0\ub108\uc9c0 \ub300\uc0ac \uc7ac\ud615\uc131\uc5d0 \uc5b4\ub5bb\uac8c \uc801\uc751\ud558\ub294\uc9c0, \uadf8\ub7ec\ud55c \ubcc0\ud654\uac00 \uc2ec\uc7a5 \ud56d\uc0c1\uc131\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\uace0 DIC\uc758 \ubc1c\uc0dd\uc73c\ub85c \uc774\uc5b4\uc9c0\ub294\uc9c0\ub294 \ubd88\ubd84\uba85\ud569\ub2c8\ub2e4. \uc0dd\uc950\uc758 \ub300\uc0ac \ub370\uc774\ud130\ub97c \ubd84\uc11d\ud558\uc5ec(<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F1\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 1C<\/a>), \uc6b0\ub9ac\ub294 Dox \ub178\ucd9c \ud6c4 \uc99d\uac00\ub41c \uc218\uce58\ub97c \ubcf4\uc774\ub294 \ub300\uc0ac\uc0b0\ubb3c\uc774 \uc8fc\ub85c \uc9c0\uc9c8 \ubd84\ub958\uc5d0 \uad00\uc5ec\ud558\uace0 \uc788\uc73c\uba70 D-\uae00\ub8e8\ucf54\uc2a4-6-\uc778\uc0b0 \ubc0f AKG\uc640 \uac19\uc740 \ud3ec\ub3c4\ub2f9 \ub300\uc0ac \uc9c0\ud45c\uc758 \uc218\uce58 \uac10\uc18c\uac00 \uba85\ubc31\ud558\ub2e4\ub294 \uac83\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. \ub354\uc6b1\uc774, KEGG \ub18d\ucd95 \ubd84\uc11d\uc5d0\uc11c\ub294 Dox \ub178\ucd9c \ud6c4 \uc9c0\uc9c8 \ub300\uc0ac \uacbd\ub85c\uac00 \ud06c\uac8c \ubcc0\uacbd\ub418\uc5c8\uc74c\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4.<a class=\"sec\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#s11\">\ubcf4\ucda9 \uadf8\ub9bc S1<\/a>). \uc2ec\uadfc \ub0b4 FAO \ub300\uc0ac\uc0b0\ubb3c MDA \uc218\uc900(<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F1\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 1D<\/a>)\ub294 Dox \uce58\ub8cc \ud6c4 \uc720\uc758\ud558\uac8c \uc99d\uac00\ud588\uc2b5\ub2c8\ub2e4. \uc774\ub294 Dox \uac1c\uc785 \ud6c4 \uc2ec\uc7a5\uc758 \ud3ec\ub3c4\ub2f9 \ub300\uc0ac\uac00 \uc190\uc0c1\ub418\uace0 \uc9c0\uc9c8 \uc5f0\uc18c \uc99d\uac00\ub85c \ub300\uccb4\ub418\uc5b4 \uc0c1\ub300\uc801\uc73c\ub85c \uc5d0\ub108\uc9c0 \ud6a8\uc728\uc774 \ub0ae\ub2e4\ub294 \uac83\uc744 \uc758\ubbf8\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ubd80\uc801\uc808\ud55c \uc9c0\uc9c8 \ub300\uc0ac\ub294 \uc2ec\uadfc\uc5d0 \ub2e4\ub7c9\uc758 \uc9c0\uc9c8 \ucd95\uc801\uc744 \uc77c\uc73c\ud0a4\uace0, \ubcd1\ub9ac\ud559\uc801 \uc5fc\uc0c9\uc744 \ud1b5\ud574 Dox\uc5d0 \ub178\ucd9c\ub41c \ub3d9\ubb3c\uc758 \uc2ec\uc7a5\uc5d0 \ub9ce\uc740 \uc218\uc758 \uc9c0\uc9c8 \uc561\ud3ec\uac00 \ub098\ud0c0\ub098 \uc2ec\uc7a5 \uc9c0\ubc29\uc99d\uc744 \uc720\ubc1c\ud569\ub2c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F1\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 1E<\/a>).<\/p>\n<\/div>\n<div id=\"s3-2\" class=\"sec\">\n<h3 id=\"s3-2title\">\uc548\ud2b8\ub77c\uc0ac\uc774\ud074\ub9b0\uc740 \uc2ec\uadfc \uc0b0\uc18c \uc18c\ube44\ub97c \uc99d\uac00\uc2dc\ud0a4\uace0 ATP \uc0dd\uc0b0 \uc18d\ub3c4\ub97c \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4.<\/h3>\n<p class=\"p p-first\">\ud765\ubbf8\ub86d\uac8c\ub3c4 \uc774\ub7ec\ud55c \ub300\uc0ac \ubcf4\uc0c1\uc740 \uc2ec\uadfc ROS \uc218\uc900\uc744 \uc99d\uac00\uc2dc\ucf1c \ub354 \ub192\uc740 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub97c \uc720\ubc1c\ud588\uc2b5\ub2c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 2A<\/a>). O2K \uc5d0\ub108\uc9c0 \ub300\uc0ac \ubd84\uc11d\uc5d0 \ub530\ub974\uba74 Dox\ub294 \uc2ec\uadfc \uc0b0\uc18c \uc18c\ube44\ub97c \uc99d\uac00\uc2dc\ucf30\uc2b5\ub2c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 2B<\/a>) \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ub9c9\uc758 \uacfc\ubd84\uadf9\uc744 \ucd08\ub798\ud588\uc2b5\ub2c8\ub2e4(<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 2C<\/a>) (\uc774\uac83\uc740 \ub610\ud55c \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\uc758 \uc99d\uac00\ub41c \uc218\uc900\uc758 \uc9d5\ud6c4\uc774\uba70 \uc2ec\uc7a5 \ud5c8\ud608-\uc7ac\uad00\ub958 \ubaa8\ub378\uc5d0\uc11c \uc885\uc885 \ubcfc \uc218 \uc788\uc2b5\ub2c8\ub2e4). JC-1 \uc5fc\uc0c9\uc740 \ub610\ud55c Dox \ub178\ucd9c\uc774 \uba87\uba87 \uc0b4\uc544\ub0a8\uc740 \uc138\ud3ec\uc5d0\uc11c \ub9c9 \uc804\uc704\uc758 \uc99d\uac00(\ube68\uac04\uc0c9 \ud615\uad11 \uac15\ub3c4\uc758 \uc99d\uac00)\ub97c \uc720\ubc1c\ud55c\ub2e4\ub294 \uac83\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 2D<\/a>). \uc0b0\uc18c \uc18c\ube44 \uc99d\uac00\uc640 \uc9c0\uc9c8 \uc0b0\ud654\uc640 \uac19\uc740 \ubcf4\uc0c1 \uacfc\uc815\uc774 \uc2ec\uc7a5\uc5d0\uc11c \ubc1c\uc0dd\ud588\uc9c0\ub9cc, \ubd88\ud589\ud558\uac8c\ub3c4 \ud3ec\ub3c4\ub2f9 \ub300\uc0ac \uac10\uc18c\uc5d0 \ubc18\uc751\ud558\uc5ec \uc2ec\uadfc\uc758 ATP \uc0dd\uc0b0 \uc18d\ub3c4\uac00 \uae09\uaca9\ud788 \uac10\uc18c\ud588\uc2b5\ub2c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 2E<\/a>). \uc0b0\uc18c \uc18c\ube44\uc728\uacfc ATP \uc0dd\uc0b0\uc728\uc744 \ube44\uad50\ud55c \uacb0\uacfc, Dox \ub178\ucd9c\ub85c \uc778\ud574 \uc2ec\uadfc\uc5d0\uc11c \ub9ce\uc740 \uc591\uc758 \uc0b0\uc18c\uac00 \uc18c\ube44\ub418\uc5c8\uc73c\ub098 \uc18c\ub7c9\uc758 ATP\ub9cc \uc0dd\uc0b0\ub418\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4(<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 2F<\/a>), \uc2ec\uc7a5\uc758 \ubd80\ub2f4\uc774 \ud06c\uac8c \uc99d\uac00\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc5d0\ub108\uc9c0 \ucd9c\ub825 \ubd80\uc871\uc73c\ub85c \uc778\ud574 Dox \uadf8\ub8f9\uc758 \uc5d0\ub108\uc9c0 \uc218\uc6a9\uccb4 AMPK \uc218\uc900\uc774 \ud06c\uac8c \uc99d\uac00\ud588\uc2b5\ub2c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 2G<\/a>). \ub530\ub77c\uc11c \uc6b0\ub9ac\ub294 \uc548\ud2b8\ub77c\uc0ac\uc774\ud074\ub9b0\uc5d0 \uc758\ud55c \ud3ec\ub3c4\ub2f9 \ub300\uc0ac \uc7a5\uc560\uc5d0 \ubc18\uc751\ud558\uc5ec \uc2ec\uc7a5\uc774 \ub192\uc740 \uc0b0\uc18c \uc18c\ube44\uc728\uacfc \ub0ae\uc740 ATP \uc0dd\uc0b0 \uc18d\ub3c4\ub97c \ub098\ud0c0\ub0b4\uba70 \uc774\ub7ec\ud55c \ud604\uc0c1\uc774 \uc2ec\uadfc\uc758 \uc5d0\ub108\uc9c0 \uc694\uad6c \uc0ac\ud56d\uc744 \uc644\uc804\ud788 \ucda9\uc871\uc2dc\ud0a4\uc9c0 \ubabb\ud558\uace0 \uacfc\ub3c4\ud55c \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub97c \ucd08\ub798\ud55c\ub2e4\uace0 \uac00\uc815\ud569\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc5d0\ub108\uc9c0 \uaca9\ucc28\uc5d0 \ub300\ud55c \ubc18\uc751\uc73c\ub85c \uc2ec\uc7a5\uc758 \uc9c0\uc9c8 \uc0b0\ud654\uac00 \uc99d\uac00\ud558\uace0 \ub354 \ub9ce\uc740 ROS\uac00 \ucd95\uc801\ub418\uba70, \uc774 \ubd88\ub7c9\ud55c \ud53c\ub4dc\ubc31 \uacbd\ub85c\uac00 DIC\uc758 \uc911\uc694\ud55c \ub3d9\uc778\uc77c \uc218 \uc788\ub2e4\uace0 \ucd94\uce21\ub429\ub2c8\ub2e4.<\/p>\n<div id=\"F2\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm139983201580624\">\n<div class=\"ts_bar small\" title=\"\ud655\ub300\ud558\ub824\uba74 \uc774\ubbf8\uc9c0\ub97c \ud074\ub9ad\ud558\uc138\uc694.\"><\/div>\n<p><a class=\"inline_block ts_canvas\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/core\/lw\/2.0\/html\/tileshop_pmc\/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&amp;p=PMC3&amp;id=9551275_fphar-13-930835-g002.jpg\" target=\"tileshopwindow\" rel=\"noopener\"><img decoding=\"async\" class=\"tileshop\" title=\"\ud655\ub300\ud558\ub824\uba74 \uc774\ubbf8\uc9c0\ub97c \ud074\ub9ad\ud558\uc138\uc694.\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/bin\/fphar-13-930835-g002.jpg\" alt=\"An external file that holds a picture, illustration, etc.Object name is fphar-13-930835-g002.jpg\" \/><\/a><\/div>\n<div id=\"lgnd_F2\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 2<\/a><\/div>\n<div class=\"caption\">\n<p><strong>(\u314f)<\/strong>\u00a0H9c2 \uc138\ud3ec\uc758 ROS \uc5fc\uc0c9 \uac15\ub3c4.\u00a0<strong>(\ube44)<\/strong>\u00a0H9c2 \uc138\ud3ec\uc758 \uc2ec\uc7a5 \uc0b0\uc18c \uc18c\ube44\ub7c9.\u00a0<strong>(\uc528)<\/strong>\u00a0\ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ub9c9 \uc804\uc704.\u00a0<strong>(\ub514)<\/strong>\u00a0JC-1 \uc5fc\uc0c9 \ubc0f \ub9c9\ub300 \uadf8\ub798\ud504.\u00a0<strong>(\uc774\uc790\ud615)<\/strong>\u00a0H9c2 \uc138\ud3ec\uc758 ATP \ud568\ub7c9.\u00a0<strong>(\uc5d0\ud504)<\/strong>\u00a0H9c2 \uc138\ud3ec\uc758 ATP \uc0dd\uc0b0\/\uc0b0\uc18c \uc18c\ube44 \ube44\uc728.\u00a0<strong>(G)<\/strong>\u00a0AMPK\uc640 \u03b2-tubulin\uc758 \ubc1c\ud604 \uc218\uc900\uc744 \uce21\uc815\ud588\uc2b5\ub2c8\ub2e4.\u00a0<em>\uc2dc\ud5d8\uad00 \ub0b4\uc5d0\uc11c<\/em>\u00a0WB\ub85c. \ucee8\ud2b8\ub864 \ub300 Dox: ***<em>\ud53c<\/em>\u00a0&lt; 0.0005, **<em>\ud53c<\/em>\u00a0&lt; 0.005, *<em>\ud53c<\/em>\u00a0&lt; 0.05, \ud3c9\uade0 \u00b1 SD.\u00a0<em>N<\/em>\u00a0= 6\u20139.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"s3-3\" class=\"sec\">\n<h3 id=\"s3-3title\">\uc0c8\ub85c\uc6b4 \uc2ec\uc7a5 \ubcf4\ud638\uc81c \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc740 \uc2ec\uc7a5 \ud3ec\ub3c4\ub2f9 \ub300\uc0ac\ub97c \ucd09\uc9c4\ud558\uace0 Dox \uc720\ubc1c \uc2ec\uadfc\ubcd1\uc99d\uc744 \uc5b5\uc81c\ud569\ub2c8\ub2e4.<\/h3>\n<p class=\"p p-first\">\ubcf8 \uc5f0\uad6c\uc5d0\uc11c\ub294 \uc774\ub7ec\ud55c \uacb0\uacfc\ub97c \ubc14\ud0d5\uc73c\ub85c \uc2ec\ud608\uad00 \uc9c8\ud658 \uce58\ub8cc\uc5d0 \uc0ac\uc6a9\ub418\ub294 \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc \ube0c\ub808\ube44\uc2a4\uce74\ud540(breviscapine)\uc758 DIC \uc9c4\ud589\uc5d0 \ub300\ud55c \ubcf4\ud638 \ud6a8\uacfc\ub97c \ub300\uc0ac\uc801 \uad00\uc810\uc5d0\uc11c \uc870\uc0ac\ud558\uc600\ub2e4. \uc2e4\ud5d8 \ud504\ub85c\ud1a0\ucf5c\uc740 \ub2e4\uc74c\uacfc \uac19\uc2b5\ub2c8\ub2e4.\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F3\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 3A<\/a>, \uadf8\ub9ac\uace0\u00a0<sup>18<\/sup>F-FDG PET\/CT \uc774\ubbf8\uc9d5\uc740 \uccab \ubc88\uc9f8 \ub3c5\uc18c\ub8e8\ube44\uc2e0 \uc8fc\uc0ac \ud6c4 1\uc8fc \ud6c4\uc5d0 \ub9c8\uc6b0\uc2a4\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc218\ud589\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc5d0 \ud45c\uc2dc\ub41c \ubc14\uc640 \uac19\uc774\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F3\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 3B<\/a>, \uc2ec\uc7a5 \ud761\uc218\ub294 Dox \ub2e8\ub3c5 \uce58\ub8cc\uad70\ubcf4\ub2e4 \ube0c\ub808\ube44\uc2a4\uce74\ud540 \uce58\ub8cc\uad70\uc5d0\uc11c \uc720\uc758\ud558\uac8c \ub354 \ub192\uc558\uc73c\uba70, \uc774\ub294 \ube0c\ub808\ube44\uc2a4\uce74\ud540 \uac1c\uc785\uc774 Dox\ub85c \uc720\ubc1c\ub41c \uc2ec\uc7a5 \ud3ec\ub3c4\ub2f9 \ub300\uc0ac \uac10\uc18c\ub97c \uc5ed\uc804\uc2dc\ud0a4\uace0 \uc2ec\uc7a5 \uc5d0\ub108\uc9c0 \ub300\uc0ac\ub97c \uc7ac\uad6c\uc131\ud560 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. \ube0c\ub808\ube44\uc2a4\uce74\ud540 \uce58\ub8cc \ud6c4 \uc2ec\uc7a5 \uae30\ub2a5 \ubc0f \ubcd1\ub9ac\ud559\uc801 \ubcc0\ud654\ub97c \uc870\uc0ac\ud558\uc600\uace0, \uc784\uc0c1\uc57d\ubb3c\uc778 dexrazoxane(Dexra)\uc744 \uc591\uc131\ub300\uc870\uad70\uc73c\ub85c \uc0ac\uc6a9\ud558\uc600\ub2e4. \uc2ec\uc7a5\ucd08\uc74c\ud30c\uac80\uc0ac\ub294\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F3\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 3C<\/a>\u00a0Dox \uadf8\ub8f9\uc758 LVEF\uc640 LVFS\ub294 \ub300\uc870\uad70\uc5d0 \ube44\ud574 \uc720\uc758\ud558\uac8c \ub0ae\uc558\uace0, LVESV\uc640 LVD\ub294 \ub300\uc870\uad70\uc5d0 \ube44\ud574 \uc720\uc758\ud558\uac8c \ub192\uc558\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uacb0\uacfc\ub294 Dox \uce58\ub8cc \ud6c4 \ub9c8\uc6b0\uc2a4\uc758 \uc88c\uc2ec\uc2e4 \uc218\ucd95\uae30 \uae30\ub2a5\uc774 \uac10\uc18c\ud588\uc73c\uba70 \ubcf8 \uc5f0\uad6c\uc5d0\uc11c Dox\ub85c \uc778\ud55c \uc2ec\uadfc \uc190\uc0c1\uc774 \ud655\uc7a5\uc131 \uc2ec\uadfc\ubcd1\uc99d\uacfc \uc720\uc0ac\ud558\ub2e4\ub294 \uac83\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. Dox \uac10\uc18c\ub41c \uc218\ucd95\uae30 \uae30\ub2a5\uc740 \uc774\uc804\uc5d0 \ubcf4\uace0\ub41c \uac83\uacfc \uc720\uc0ac\ud569\ub2c8\ub2e4(<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B46\" aria-expanded=\"false\" aria-haspopup=\"true\">\ubca4\uce04\ub9ac\ub2c8 \uc678, 1996<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B41\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc120 \uc678, 2022<\/a>). \ub3c5\uc18c\ub8e8\ube44\uc2e0\ub9cc \ud22c\uc5ec\ud55c \ub3d9\ubb3c\uc5d0 \ube44\ud574 Brev\uc640 Dox\ub97c \ud22c\uc5ec\ud55c \ub3d9\ubb3c\uc758 \uc2ec\uc7a5\uc5d0\uc11c\ub294 \ubaa8\ub4e0 \uae30\ub2a5\uc774 \ud68c\ubcf5\ub418\uc5c8\uc2b5\ub2c8\ub2e4. cTnI\ub294 \uc2ec\uadfc \uc190\uc0c1\uc758 \ubc14\uc774\uc624\ub9c8\ucee4\uc785\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B40\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc194\ub77c\ub85c\uc640 \uc194\ub77c\ub85c, 2020<\/a>). cTnI\uc758 \ub18d\ub3c4\ub294 doxorubicin \ub2e8\ub3c5 \ud22c\uc5ec\uad70\uc5d0\uc11c \ub300\uc870\uad70\uc5d0 \ube44\ud574 \uc720\uc758\ud558\uac8c \uc99d\uac00\ud558\uc600\uace0, Brev\uc758 \ub18d\ub3c4\ub97c \ub2e4\ub974\uac8c \ud588\uc744 \ub54c \ub354 \uc88b\uc740 \ud6a8\uacfc\uac00 \ub098\ud0c0\ub0ac\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F3\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 3D<\/a>). \ub610\ud55c, \ub2e4\uc591\ud55c \ucc98\ub9ac \ud6c4 \ubcd1\ub9ac\ud559\uc801 \uc2ec\uc7a5 \uc870\uc9c1\uc758 \uc5fc\uc0c9\uc744 \ud1b5\ud574 \ub300\uc870\uad70 \uc950\uc758 \uc2ec\uc7a5 \uc870\uc9c1 \uad6c\uc870\uac00 \uc815\uc0c1\uc784\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4. \ub300\uc870\uad70\uacfc \ub2ec\ub9ac Dox \uadf8\ub8f9\uc758 \uc950\ub294 \uad34\uc0ac, \uc138\ud3ec\ub0b4 \ubd80\uc885, \uadfc\uc12c\uc720 \uc7a5\uc560 \ubc0f \ud30c\uc5f4, \uc2ec\uc7a5 \uc12c\uc720\uc758 \ubb3c\uacb0 \ubaa8\uc591 \ubcc0\uc131\uc744 \ud3ec\ud568\ud558\uc5ec \ub9ce\uc740 \uc218\uc758 \uc2ec\uc7a5 \ubcd1\ubcc0\uc744 \ub098\ud0c0\ub0c8\uc2b5\ub2c8\ub2e4. \ud765\ubbf8\ub86d\uac8c\ub3c4, \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc744 \uc0ac\uc6a9\ud55c \uc804\ucc98\uce58(preconditioning)\ub294 \uc774\ub7ec\ud55c \uc720\ud615\uc758 \uc190\uc0c1\uc744 \uc608\ubc29\ud558\uace0 \uc2ec\uc7a5 \uc9c0\uc9c8\uc758 \uacfc\ub3c4\ud55c \ucd95\uc801\uc744 \uc644\ud654\ud558\uba70 \uc2ec\uadfc \ud56d\uc0c1\uc131\uc744 \ud68c\ubcf5\uc2dc\ucf30\uc2b5\ub2c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F3\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 3F<\/a>). \uc2ec\uadfc\uc758 Masson \uc5fc\uc0c9\uc740 Dox \uce58\ub8cc \ud6c4 \uac04\uc9c8\uc131 \uc12c\uc720\uc99d\uc774 \uc720\uc758\ud558\uac8c \uc99d\uac00\ud588\uc73c\uba70 Brev \uac1c\uc785\uc774 \uc2ec\uc7a5 \uc12c\uc720\uc99d\uc758 \uc815\ub3c4\ub97c \uac10\uc18c\uc2dc\ud0a4\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F3\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 3E<\/a>). \uc2ec\uc7a5 \ucd08\uc74c\ud30c \ub370\uc774\ud130\uc5d0 \ub530\ub974\uba74 LVESV \ubc0f LVID\ub294 \ub300\uc870\uad70\uc5d0 \ube44\ud574 Dox \uad70\uc5d0\uc11c \uc720\uc758\ud558\uac8c \ub192\uc558\uc73c\uba70 \uc774\ub294 \uc2ec\uc2e4\uac15 \uc9c1\uacbd \ud655\ub300\ub97c \uc2dc\uc0ac\ud558\uace0 \ube0c\ub808\ube44\uc2a4\uce74\ud540 \uce58\ub8cc\uac00 \uc774\ub7ec\ud55c \ubcc0\ud654\ub97c \uc720\uc758\ud558\uac8c \uc644\ud654\ud560 \uc218 \uc788\uc74c\uc744 \ub098\ud0c0\ub0c5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uacb0\uacfc\ub294 \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc774 \uc2ec\uc7a5 \ub300\uc0ac\ub97c \uc7ac\uad6c\uc131\ud558\uace0, \uc2ec\uc7a5 \ud3ec\ub3c4\ub2f9 \ud761\uc218\ub97c \uc99d\uac00\uc2dc\ud0a4\uba70, \uc2ec\uc7a5 \uc9c0\ubc29\uc99d\uc744 \uac10\uc18c\uc2dc\ud0a4\uace0, \ub3c5\uc18c\ub8e8\ube44\uc2e0\uc5d0 \uc758\ud574 \uc720\ubc1c\ub41c \uc2ec\uc7a5 \uae30\ub2a5 \uc7a5\uc560\uc640 \uc2ec\uadfc \ud615\ud0dc\uc758 \ubcc0\ud654\ub97c \uc644\ud654\ud560 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4.<\/p>\n<div id=\"F3\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm139983204545024\">\n<div class=\"ts_bar small\" title=\"\ud655\ub300\ud558\ub824\uba74 \uc774\ubbf8\uc9c0\ub97c \ud074\ub9ad\ud558\uc138\uc694.\"><\/div>\n<p><a class=\"inline_block ts_canvas\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/core\/lw\/2.0\/html\/tileshop_pmc\/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&amp;p=PMC3&amp;id=9551275_fphar-13-930835-g003.jpg\" target=\"tileshopwindow\" rel=\"noopener\"><img decoding=\"async\" class=\"tileshop\" title=\"\ud655\ub300\ud558\ub824\uba74 \uc774\ubbf8\uc9c0\ub97c \ud074\ub9ad\ud558\uc138\uc694.\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/bin\/fphar-13-930835-g003.jpg\" alt=\"An external file that holds a picture, illustration, etc.Object name is fphar-13-930835-g003.jpg\" \/><\/a><\/div>\n<div id=\"lgnd_F3\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F3\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 3<\/a><\/div>\n<div class=\"caption\">\n<p><strong>(\u314f)<\/strong>\u00a0\ub9c8\uc6b0\uc2a4 \uce58\ub8cc\ub97c \uc704\ud55c \ub3c4\uc2dd\uc801 \ud504\ub85c\ud1a0\ucf5c.\u00a0<strong>(\ube44)<\/strong>\u00a0<sup>18<\/sup>F-FDG PET\/CT \uc601\uc0c1\uc740 \uccab \ubc88\uc9f8 Dox \ub178\ucd9c 1\uc8fc \ud6c4 \ub9c8\uc6b0\uc2a4\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc218\ud589\ub418\uc5c8\uc73c\uba70, 18F-FDG\uc758 \ub18d\ub3c4\ub294 \uc2ec\uc7a5\uc5d0 \ud761\uc218\ub418\uc5c8\uc2b5\ub2c8\ub2e4.\u00a0<strong>(\uc528)<\/strong>\u00a0\ube0c\ub808\ube44\uc2a4\uce74\ud540\uc774 Dox\uc5d0 \uc758\ud574 \uc720\ubc1c\ub41c \uc88c\uc2ec\uc2e4 \ud655\uc7a5\uc744 \uc608\ubc29\ud588\uc74c\uc744 \ubcf4\uc5ec\uc8fc\ub294 \uc2ec\uc7a5\ucd08\uc74c\ud30c\uac80\uc0ac. Dox\uac00 \uc88c\uc2ec\uc2e4 \ud655\uc7a5\uc744 \uc720\ub3c4\ud558\uace0 \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc774 Dox + Brev \uadf8\ub8f9\uc5d0\uc11c \ubcf4\ud638 \ud6a8\uacfc\ub97c \ubc1c\ud718\ud588\uc74c\uc744 \ubcf4\uc5ec\uc8fc\ub294 \ub300\ud45c\uc801\uc778 M \ubaa8\ub4dc \ub2e8\ucd95 \uc2ec\ucd08\uc74c\ud30c\ub3c4\uc785\ub2c8\ub2e4. \ud655\uc7a5\uae30\uc758 EF\uc640 FS\ub294 Dox\ub85c \uce58\ub8cc\ud55c \uc950\ubcf4\ub2e4 \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc73c\ub85c \uce58\ub8cc\ud55c \uc950\uc5d0\uc11c \uc720\uc758\ud558\uac8c \ub0ae\uc558\uace0 HR\uc740 \uc720\uc758\ud558\uac8c \ub354 \ub192\uc558\uc2b5\ub2c8\ub2e4.\u00a0<strong>(\ub514)<\/strong>\u00a0\ube0c\ub808\ube44\uc2a4\uce74\ud540\uc740 cTnI\uc758 \ub18d\ub3c4\ub97c \uac10\uc18c\uc2dc\ucf30\uc2b5\ub2c8\ub2e4.\u00a0<strong>(\uc774\uc790\ud615)<\/strong>\u00a0\ube0c\ub808\ube44\uc2a4\uce74\ud540\uc774 Dox\uc5d0 \uc758\ud574 \uc720\ubc1c\ub41c \uc2ec\uc7a5 \uc12c\uc720\uc99d\uc758 \uc815\ub3c4\ub97c \uac10\uc18c\uc2dc\ud0a4\ub294 \uac83\uc744 \ubcf4\uc5ec\uc8fc\ub294 Masson \uc5fc\uc0c9.\u00a0<strong>(\uc5d0\ud504)<\/strong>\u00a0HE \uc5fc\uc0c9\uc740 \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc774 \uc2ec\uc7a5\uc5d0\uc11c Dox\uc5d0 \uc758\ud574 \uc720\ubc1c\ub41c \uc2ec\uadfc\uc138\ud3ec \ud06c\uae30\uc758 \uac10\uc18c\ub97c \ubc29\uc9c0\ud55c\ub2e4\ub294 \uac83\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4. \ub300\uc870\uad70 \ub300 Dox, 4 mg\/kg, 8 mg\/kg \ub610\ub294 16 mg\/kg Brev \ub300 Dox \ubc0f Dexra \ub300 Dox: ***<em>\ud53c<\/em>\u00a0&lt; 0.0005, **<em>\ud53c<\/em>\u00a0&lt; 0.005, *<em>\ud53c<\/em>\u00a0&lt; 0.05, \ud3c9\uade0 \u00b1 SD.\u00a0<em>N<\/em>\u00a0= 6\u20139.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"s3-4\" class=\"sec\">\n<h3 id=\"s3-4title\">Breviscapine\uc740 \ub9d0\ucd08 \ud608\uccad \uc218\uc900\uacfc \uc2ec\uadfc AKT \ubc1c\ud604\uc744 \uc870\uc808\ud558\uc5ec \uc2ec\uc7a5 \ud3ec\ub3c4\ub2f9\uacfc \uc9c0\uc9c8 \ub300\uc0ac\ub97c \uc7ac\uad6c\uc131\ud569\ub2c8\ub2e4.<\/h3>\n<p class=\"p p-first\">\ub2e4\uc74c\uc73c\ub85c, \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc774 \ub2f9\uacfc \uc9c0\ubc29 \ub300\uc0ac\uc758 \uade0\ud615\uc744 \uc5b4\ub5bb\uac8c \uc870\uc808\ud558\ub294\uc9c0 \uc5f0\uad6c\ud588\uc2b5\ub2c8\ub2e4. \uc5d0 \ud45c\uc2dc\ub41c \ubc14\uc640 \uac19\uc774\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F4\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 4E<\/a>, Breviscapine \ucc98\ub9ac \uc0dd\uc950\uc758 \ub9d0\ucd08 \ud608\uccad \uc138\ub85c\ud1a0\ub2cc \uc218\uc900\uc740 Dox \ucc98\ub9ac \uc0dd\uc950\uc5d0 \ube44\ud574 \uae09\uaca9\ud558\uac8c \uc99d\uac00\ud588\uc73c\uba70, \uac10\uc18c \uc815\ub3c4\ub294 \ube0c\ub808\ube44\uc2a4\uce74\ud540 \uc6a9\ub7c9\uacfc \uc120\ud615 \uad00\uacc4\ub97c \ub098\ud0c0\ub0b4\uc5c8\uc73c\uba70 95% \uc774\uc0c1 \uac10\uc18c\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \uace0\uc6a9\ub7c9\uad70\uc5d0\uc11c \uad00\ucc30\ub410\ub2e4. \uc138\ub85c\ud1a0\ub2cc(5-HT)\uc740 \uc2e0\uacbd \ubc0f \ube44\uc2e0\uacbd \uc2dc\uc2a4\ud15c\uc5d0\uc11c \ub2e4\uc591\ud55c \uae30\ub2a5\uc744 \uac16\ub294 \ubaa8\ub178\uc544\ubbfc\uc785\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B31\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc624\uce74\ud2f0 \uc678, 2019<\/a>). \uc911\ucd94\uc2e0\uacbd\uacc4\uc5d0\uc11c 5-HT\ub294 \uae30\ubd84\uacfc \uc12d\uc2dd \ud589\ub3d9\uc744 \uc870\uc808\ud558\ub294 \uc2e0\uacbd\uc804\ub2ec\ubb3c\uc9c8\ub85c \uc791\uc6a9\ud569\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B2\" aria-expanded=\"false\" aria-haspopup=\"true\">\ubc84\uac70 \uc678., 2009<\/a>). \ucd5c\uadfc \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \ub9d0\ucd08 5-HT\ub294 \uac08\uc0c9 \uc9c0\ubc29 \uc870\uc9c1\uc5d0\uc11c \uc801\uc751\uc131 \uc5f4 \ubc1c\uc0dd\uc744 \uc5b5\uc81c\ud568\uc73c\ub85c\uc368 \ub9d0\ucd08 \uc870\uc9c1\uc758 \ub300\uc0ac \uc870\uc808\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. 5-HT \ud569\uc131 \uc5b5\uc81c\ub294 \uc2dd\uc774 \uc720\ubc1c \ube44\ub9cc \uc950 \ubaa8\ub378\uc5d0\uc11c \uccb4\uc911 \uc99d\uac00\ub97c \uac10\uc18c\uc2dc\ud0a4\uace0 \ub300\uc0ac \uae30\ub2a5 \uc7a5\uc560\ub97c \uac1c\uc120\ud569\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B56\" aria-expanded=\"false\" aria-haspopup=\"true\">Zemdegs \ub4f1, 2016<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B51\" aria-expanded=\"false\" aria-haspopup=\"true\">Xia \uc678, 2021<\/a>). \uac8c\ub188 \ucc28\uc6d0\uc758 \uc5f0\uad00 \uc5f0\uad6c\uc5d0\uc11c\ub3c4 \uc138\ub85c\ud1a0\ub2cc \uc2dc\uc2a4\ud15c\uacfc \ube44\ub9cc \uc0ac\uc774\uc758 \uc720\uc804\uc801 \uc5f0\uad00\uc131\uc774 \ubc1d\ud600\uc84c\uc2b5\ub2c8\ub2e4. \uc138\ub85c\ud1a0\ub2cc\uc740 \ud3ec\ub3c4\ub2f9 \ub300\uc0ac\uc5d0 \ub450 \uac00\uc9c0 \ub2e4\ub978 \ud6a8\uacfc\ub97c \uac16\uc2b5\ub2c8\ub2e4. \uc989, \ucdcc\uc7a5 B \uc138\ud3ec\uc5d0\uc11c \uc778\uc290\ub9b0 \ubd84\ube44\ub97c \uc9c1\uc811 \uc720\ub3c4\ud558\uc5ec \ud608\ub2f9 \uc218\uce58\ub97c \ub0ae\ucd94\ub294 \uac83\uc785\ub2c8\ub2e4. \uac04\uacfc \uace8\uaca9\uadfc \uc774\uc678\uc758 \uc870\uc9c1\uc774 \ud608\uc561\uc5d0\uc11c \ud3ec\ub3c4\ub2f9\uc744 \ud761\uc218\ud558\ub294 \uac83\uc744 \uc5b5\uc81c\ud558\uc5ec \ud608\ub2f9 \uc218\uce58\ub97c \ub192\uc785\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B47\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc640\ud0c0\ub098\ubca0 \uc678, 2011<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B4\" aria-expanded=\"false\" aria-haspopup=\"true\">\uce74\ub974\ubbf8\uc548 \uc678, 2019<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B53\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc57c\ubd80\ud2b8 \uc678, 2019<\/a>). \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \uc138\ub85c\ud1a0\ub2cc \uce58\ub8cc\ub294 \ud608\ub2f9 \uc218\uce58\ub97c \uac11\uc791\uc2a4\ub7fd\uace0 \ud06c\uac8c \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\uc9c0\ub9cc \uc138\ub85c\ud1a0\ub2cc\uc774 \ud608\uc561\uc5d0\uc11c \uc870\uc9c1\uc758 \ud3ec\ub3c4\ub2f9 \ud761\uc218\ub97c \uc5b4\ub5bb\uac8c \uc5b5\uc81c\ud558\ub294\uc9c0\ub294 \ubd88\ubd84\uba85\ud569\ub2c8\ub2e4. \uc6b0\ub9ac\uc758 \uc2e4\ud5d8 \uacb0\uacfc\uc5d0 \ub530\ub974\uba74 \ube0c\ub808\ube44\uc2a4\uce74\ud540 \uce58\ub8cc \ud6c4 \ub9d0\ucd08 \uc138\ub85c\ud1a0\ub2cc \uc218\uce58\uac00 \uae09\uaca9\ud788 \uac10\uc18c\ud588\uc73c\uba70 \uc774\ub294 \uc2ec\uc7a5 \ud3ec\ub3c4\ub2f9 \uc12d\ucde8\ub7c9\uc758 \uc99d\uac00\uc5d0 \uc0c1\uc751\ud569\ub2c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F4\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 4E<\/a>), \uac04 \ud3ec\ub3c4\ub2f9 \uc12d\ucde8\ub7c9\uc740 \ud06c\uac8c \ubcc0\ud558\uc9c0 \uc54a\uc558\uc9c0\ub9cc(<a class=\"sec\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#s11\">\ubcf4\ucda9 \uadf8\ub9bc S2<\/a>) \ubc0f \uacf5\ubcf5 \ud608\ub2f9(FBG) \uc218\uce58\uac00 \uac10\uc18c\ud588\uc2b5\ub2c8\ub2e4(<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F4\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 4A<\/a>). \ube0c\ub808\ube44\uc2a4\uce74\ud540 \uadf8\ub8f9\uc5d0\uc11c 5-HT\ub97c \ucd94\uac00\ub85c \ubcf4\ucda9\ud558\uba74 \uc0dd\uc950\uc758 \uc138\ub85c\ud1a0\ub2cc \uc218\uce58\uac00 \uc99d\uac00\ud558\uace0 \uc2ec\uc7a5 \ud3ec\ub3c4\ub2f9 \ud761\uc218\uac00 \uac10\uc18c\ud588\uc2b5\ub2c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F4\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 4B<\/a>). \uc138\ub85c\ud1a0\ub2cc\uc774 \uc2ec\uadfc\uc138\ud3ec \ub300\uc0ac\ub97c \uc870\uc808\ud558\ub294 \ubc29\ubc95\uc744 \ucd94\uac00\ub85c \ubd84\uc11d\ud558\uae30 \uc704\ud574 Dox \uc720\ubc1c \uc2ec\uadfc \uc190\uc0c1 \ubaa8\ub378 \ub9c8\uc6b0\uc2a4\uc5d0\uc11c \uc138\ub85c\ud1a0\ub2cc \uc218\uc900\uc744 \ub192\uc774\uae30 \uc704\ud574 5-HT\ub97c \ucd94\uac00\ud55c \ub2e4\uc74c \uc804\uc0ac\uccb4 \ubd84\uc11d\uc744 \uc704\ud574 \ub9c8\uc6b0\uc2a4\uc758 \uc2ec\uc7a5\uc744 \uc218\uc9d1\ud588\uc2b5\ub2c8\ub2e4. \uadf8 \uacb0\uacfc, Dox\uc640 5-HT\ub97c \ucc98\ub9ac\ud55c \uadf8\ub8f9\uc758 \uc9c0\ubc29\uc0b0 \uc0b0\ud654\uac00 Dox\ub9cc \ucc98\ub9ac\ud55c \uadf8\ub8f9\ubcf4\ub2e4 \uc720\uc758\ud558\uac8c \ub192\uc740 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<a class=\"sec\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#s11\">\ubcf4\ucda9 \uadf8\ub9bc S3<\/a>). \uadf8\ub7f0 \ub2e4\uc74c \uc6b0\ub9ac\ub294 \ud3ec\ub3c4\ub2f9 \ud761\uc218 \uc870\uc808\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\ub294 \uc2ec\uadfc \ud3ec\ub3c4\ub2f9 \ub300\uc0ac\uc758 \uc911\uc694\ud55c \uc870\uc808\uc790\uc778 PI3K \ub2e8\ubc31\uc9c8 \ud0a4\ub098\uc81c B(Akt\/PKB) \uacbd\ub85c\uc758 \ubcc0\ud654\ub97c \ubd84\uc11d\ud588\uc2b5\ub2c8\ub2e4. \uc138\ud3ec \ubd84\uc5f4, \uc99d\uc2dd \ubc0f \uc0dd\uc874 \ucd09\uc9c4; \uadf8\ub9ac\uace0 \uc138\ud3ec\uc0ac\uba78\uc744 \uc5b5\uc81c\ud569\ub2c8\ub2e4. \uacb0\uacfc\ub294 5-HT\uc758 \ucca8\uac00\uac00 Akt\uc758 \uc720\uc804\uc790 \ubc1c\ud604\uc744 \uc9c1\uc811\uc801\uc73c\ub85c \uc5b5\uc81c\ud588\uc9c0\ub9cc PI3K \ucd09\ub9e4 \uc11c\ube0c\uc720\ub2db\uc774\ub098 \uc870\uc808 \uc11c\ube0c\uc720\ub2db \uc218\uc900\uc744 \ud06c\uac8c \ubcc0\ud654\uc2dc\ud0a4\uc9c0 \uc54a\uc558\uc74c\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F4\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 4C<\/a>). AKT\uc758 \uc190\uc2e4\uc740 \uc2ec\uadfc\uc138\ud3ec\uc758 \ud3ec\ub3c4\ub2f9 \ub300\uc0ac \ub2a5\ub825\uc744 \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uacb0\uacfc\ub294 \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc774 \uc138\ub85c\ud1a0\ub2cc \uc218\uc900\uc744 \ud06c\uac8c \uac10\uc18c\uc2dc\ucf1c \uc870\uc9c1\uc758 \ud3ec\ub3c4\ub2f9 \ud761\uc218\uc5d0 \ub300\ud55c \uc138\ub85c\ud1a0\ub2cc\uc758 \uc5b5\uc81c \ud6a8\uacfc\ub97c \uc644\ud654\ud558\uace0 \ubcd1\ub9ac\ud559\uc801 \uc0c1\ud0dc\uc5d0\uc11c \ud608\uc561\uc5d0\uc11c \ud3ec\ub3c4\ub2f9\uc758 \ud761\uc218\ub97c \ubcf4\uc7a5\ud558\uc5ec \uc2e0\uccb4\uac00 \uc2ec\uc7a5 \ub300\uc0ac \uc870\uc808\uc5d0 \ucc38\uc5ec\ud560 \uc218 \uc788\ub294 \uac00\ub2a5\uc131\uc744 \ub098\ud0c0\ub0c4\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. \uc2e0\uacbd\uc804\ub2ec\ubb3c\uc9c8\uc744 \ud1b5\ud55c \ub9ac\ubaa8\ub378\ub9c1. \ub354 \uc911\uc694\ud55c \uac83\uc740, \uc911\uad6d\uc5d0\uc11c \uc77c\ubc18\uc801\uc73c\ub85c \uc0ac\uc6a9\ub418\ub294 \uc2ec\ud608\uad00 \uc57d\ubb3c\uc778 \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc740 \ub9d0\ucd08 \uc138\ub85c\ud1a0\ub2cc \uc218\uc900\uc744 90% \uc774\uc0c1 \uac10\uc18c\uc2dc\ud0ac \uc218 \uc788\uc73c\uba70 \uc2ec\uadfc \ud3ec\ub3c4\ub2f9 \ub300\uc0ac\ub85c \uc778\ud55c \uc2ec\uadfc \ube44\ub300 \ubc0f \uc2ec\ubd80\uc804 \uce58\ub8cc\uc5d0\uc11c \uace0\uc804\uc801\uc778 \uc138\ub85c\ud1a0\ub2cc \uc7ac\ud761\uc218 \uc5b5\uc81c\uc81c\uc778 \ud50c\ub8e8\uc625\uc138\ud2f4\ubcf4\ub2e4 \ub354 \uac15\ub825\ud55c \ud6a8\uacfc\uac00 \uc788\ub2e4\ub294 \uac83\uc785\ub2c8\ub2e4. Dox\ub85c \uc778\ud55c \uc2ec\uc7a5 \ub3c5\uc131 \uce58\ub8cc\ub97c \uc704\ud55c \uc0c8\ub85c\uc6b4 \uc548\uc804\ud55c \uc57d\uc81c\ub97c \ub300\ud45c\ud558\ub294 \uc7a5\uc560 \ubc0f \ub2f9\ub1e8\ubcd1. \uc5ed\ud559 \uc5f0\uad6c\uc5d0\uc11c\ub294 \ub2f9\ub1e8\ubcd1\uc774 Dox\ub85c \uc778\ud55c \uc2ec\uc7a5 \ub3c5\uc131 \uc704\ud5d8\uc744 \uc99d\uac00\uc2dc\ud0a4\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc774 \uc5f0\uad6c\ub294 \ub2f9\ub1e8\ubcd1\uacfc \uc554 \ud658\uc790\uc5d0 \ub300\ud55c \uc7a0\uc7ac\uc801\uc778 \uce58\ub8cc \uc804\ub7b5\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B5\" aria-expanded=\"false\" aria-haspopup=\"true\">\ucc3d \uc678, 2021<\/a>).<\/p>\n<div id=\"F4\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm139983196531152\">\n<div class=\"ts_bar small\" title=\"\ud655\ub300\ud558\ub824\uba74 \uc774\ubbf8\uc9c0\ub97c \ud074\ub9ad\ud558\uc138\uc694.\"><\/div>\n<p><a class=\"inline_block ts_canvas\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/core\/lw\/2.0\/html\/tileshop_pmc\/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&amp;p=PMC3&amp;id=9551275_fphar-13-930835-g004.jpg\" target=\"tileshopwindow\" rel=\"noopener\"><img decoding=\"async\" class=\"tileshop\" title=\"\ud655\ub300\ud558\ub824\uba74 \uc774\ubbf8\uc9c0\ub97c \ud074\ub9ad\ud558\uc138\uc694.\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/bin\/fphar-13-930835-g004.jpg\" alt=\"An external file that holds a picture, illustration, etc.Object name is fphar-13-930835-g004.jpg\" \/><\/a><\/div>\n<div id=\"lgnd_F4\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F4\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 4<\/a><\/div>\n<div class=\"caption\">\n<p><strong>(\u314f)<\/strong>\u00a0\uc0dd\uc950\uc758 \uacf5\ubcf5 \ud608\ub2f9 \uc218\uce58.\u00a0<strong>(\ube44)<\/strong>\u00a0\ub18d\ub3c4\u00a0<sup>18<\/sup>F-FDG\ub294 5-HT \ubcf4\ucda9 \ud6c4 \uc2ec\uc7a5\uc5d0 \ud761\uc218\ub429\ub2c8\ub2e4.\u00a0<strong>(\uc528)<\/strong>\u00a05-HT \ubcf4\ucda9 \ud6c4 \uc804\uc0ac\uccb4 \ubd84\uc11d\uc758 \ud788\ud2b8\ub9f5.\u00a0<strong>(\ub514)<\/strong>\u00a0PI3K, Akt \ubc0f GAPDH\uc758 \ubc1c\ud604 \uc218\uc900\uc744 \uce21\uc815\ud588\uc2b5\ub2c8\ub2e4.\u00a0<em>\uc2dc\ud5d8\uad00 \ub0b4\uc5d0\uc11c<\/em>\u00a0WB\ub85c.\u00a0<strong>(\uc774\uc790\ud615)<\/strong>\u00a0\uc0dd\uc950\uc758 \ub9d0\ucd08 \ud608\uccad\uc758 \uc138\ub85c\ud1a0\ub2cc \uc218\uc900.\u00a0<strong>(\uc5d0\ud504)<\/strong>\u00a0\uc0dd\uc950\uc758 D-\uae00\ub8e8\ucf54\uc2a4 6-\uc778\uc0b0 \uc218\uc900.\u00a0<strong>(G)<\/strong>\u00a0\uc0dd\uc950\uc758 \u03b1-\ucf00\ud1a0\uae00\ub8e8\ud0c0\ub974\uc0b0 \uc218\uc900. \ub300\uc870\uad70 \ub300 Dox, 4 mg\/kg, 8 mg\/kg \ub610\ub294 16 mg\/kg Brev \ub300 Dox \ubc0f Brev+5-HT \ub300 Brev: ***<em>\ud53c<\/em>\u00a0&lt; 0.0005, **<em>\ud53c<\/em>\u00a0&lt; 0.005, *<em>\ud53c<\/em>\u00a0&lt; 0.05, \ud3c9\uade0 \u00b1 SD.\u00a0<em>N<\/em>\u00a0= 6\u20139.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p class=\"p\">\uc774\ub7ec\ud55c \ubc1c\uacac\uc744 \ubc14\ud0d5\uc73c\ub85c \uc6b0\ub9ac\ub294 \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc774 \ud3ec\ub3c4\ub2f9\uc744 \uc5b4\ub5bb\uac8c \uc870\uc808\ud558\ub294\uc9c0 \uc870\uc0ac\ud588\uc2b5\ub2c8\ub2e4. \ub9c8\uc74c\uc73c\ub85c \ud65c\uc6a9. \uacb0\uacfc\ub294 Dox\uc5d0 \ub178\ucd9c\ub41c \uc0dd\uc950\uc5d0\uc11c PI3K \ub2e8\ubc31\uc9c8 \ubc1c\ud604\uc774 \uc720\uc758\ud558\uac8c \uac10\uc18c\ud588\uc73c\uba70 \ube0c\ub808\ube44\uc2a4\uce74\ud540 \uac1c\uc785 \ud6c4 \uc2ec\uc7a5 \uc870\uc9c1\uc758 PI3K \ub2e8\ubc31\uc9c8 \ubc1c\ud604 \uc218\uc900\uc774 \uc720\uc758\ud558\uac8c \uc99d\uac00\ud588\uc74c\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4. \ud765\ubbf8\ub86d\uac8c\ub3c4 AKT \ubc1c\ud604\uc740 \ub300\uc870\uad70\uacfc Dox \ub178\ucd9c\uad70 \ubaa8\ub450\uc5d0\uc11c \ub0ae\uc740 \uc218\uc900\uc73c\ub85c \uc720\uc9c0\ub418\uc5c8\uc73c\uba70, \ube0c\ub808\ube44\uc2a4\uce74\ud540 \uce58\ub8cc \ud6c4\uc5d0\ub294 AKT \ubc1c\ud604\uc774 \uc720\uc758\ud558\uac8c \uc99d\uac00\ud55c \uac83\uc774 \uad00\ucc30\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F4\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 4D<\/a>). \uc774\uc804 \uc5f0\uad6c\uc5d0\uc11c\ub294 AKT\uac00 \uc138\ud3ec\uc758 \ud3ec\ub3c4\ub2f9 \ub300\uc0ac\ub97c \uc790\uadf9\ud558\uc5ec \ud3ec\ub3c4\ub2f9\uc744 D-\uae00\ub8e8\ucf54\uc2a4 6-\uc778\uc0b0\uc73c\ub85c \uc804\ud658\uc2dc\ud0a4\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.\u00a0<em>~\uc744 \ud1b5\ud574<\/em>\u00a0\ud574\ub2f9\uacfc\uc815\uc774\ub098 \uae00\ub9ac\ucf54\uac90 \uc911\ud569\uc744 \uc704\ud55c \ud5e5\uc18c\ud0a4\ub098\uc81c. \uc6b0\ub9ac\uc758 \uacb0\uacfc\ub294 \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc774 \uc2ec\uadfc AKT\uc758 \ubc1c\ud604\uc744 \ucd09\uc9c4\ud55c \ud6c4 \ud3ec\ub3c4\ub2f9 \ub300\uc0ac \uad00\ub828 D-\uae00\ub8e8\ucf54\uc2a4 6-\uc778\uc0b0 \ubc0f \u03b1-\ucf00\ud1a0\uae00\ub8e8\ud0c0\ub974\uc0b0 \uc218\uce58\uac00 \uc720\uc758\ud558\uac8c \uc99d\uac00\ud55c \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F4\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 4F<\/a>,G) \uc774\ub294 \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc774 AKT\ub97c \ud1b5\ud574 \ud3ec\ub3c4\ub2f9\uc744 \uc5d0\ub108\uc9c0\uc6d0\uc73c\ub85c \uc0ac\uc6a9\ud558\ub294 \uc2ec\uadfc\uc758 \ub2a5\ub825\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\uace0 \ud3ec\ub3c4\ub2f9 \uc774\ud654\uc791\uc6a9\uc744 \ucd09\uc9c4\ud55c\ub2e4\ub294 \uac83\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. \uc774\uc804 \uc5f0\uad6c\uc5d0\uc11c\ub294 PI3K-Akt \ubc1c\ud604\uc774 \uc99d\uac00\ud558\uba74 \ub9d0\ucd08 \uc870\uc9c1\uc5d0\uc11c \ub2f9 \ud65c\uc6a9\uc744 \ucd09\uc9c4\ud558\uace0, \uc778\uc290\ub9b0 \uc800\ud56d\uc131\uc744 \uac10\uc18c\uc2dc\ud0a4\uba70, \uc2ec\uc7a5 \uc5d0\ub108\uc9c0 \uacf5\uae09\uc744 \uac15\ud654\ud558\uace0 \uc2ec\ubd80\uc804\uc744 \uc608\ubc29\ud560 \uc218 \uc788\ub294 \ubc18\uba74, PI3K-Akt \uacbd\ub85c\ub97c \uc5b5\uc81c\ud558\uba74 \uc2ec\uc7a5 \uc138\ud3ec\uc758 \uc0dd\ub9ac\uc801 \ud65c\ub3d9\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \uac83\uc73c\ub85c \ubcf4\uace0\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B57\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc8fc \uc678., 2013<\/a>). \uc774\ub7ec\ud55c \uacb0\uacfc\ub294 \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc774 PI3K-Akt \uacbd\ub85c\uc758 \ud65c\uc131\ud654\ub97c \uc870\uc808\ud568\uc73c\ub85c\uc368 Dox \uc720\ubc1c \uc2ec\uadfc \uc190\uc0c1\uc5d0 \ub300\ud55c \uc800\ud56d\uc131\uc744 \ud5a5\uc0c1\uc2dc\ud0a8\ub2e4\ub294 \uac83\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uacb0\uacfc\ub294 \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc774 \uc138\ub85c\ud1a0\ub2cc\uc744 \uc5b5\uc81c\ud558\uc5ec \ud608\ub2f9 \uc218\uce58\ub97c \uc870\uc808\ud558\uace0 \uc2ec\uadfc \ub0b4 \ud3ec\ub3c4\ub2f9 \ud65c\uc6a9 \uc81c\ud55c\uc744 \ucc28\ub2e8\ud558\uba70 PI3K-Akt \uacbd\ub85c\ub97c \ud65c\uc131\ud654\ud558\uc5ec \uc2ec\uadfc \ub0b4 \ud3ec\ub3c4\ub2f9 \ub300\uc0ac\ub97c \ucd09\uc9c4\ud55c\ub2e4\ub294 \uac83\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc138\ub85c\ud1a0\ub2cc\uc740 \uc2ec\uc7a5 \ub2f9\uc9c0\uc9c8 \ub300\uc0ac\ub97c \uc870\uc808\ud558\ub294 \uc911\uc694\ud55c \ud45c\uc801\uc774 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub7f0 \ub2e4\uc74c \uc2ec\uadfc \ub2f9\uc9c0\uc9c8 \ub300\uc0ac\uc758 \ub9ac\ubaa8\ub378\ub9c1\uc5d0 \ub530\ub978 \uc2ec\uc7a5 \uae30\ub2a5 \ubc0f \ud56d\uc0c1\uc131\uc758 \ubcc0\ud654\ub97c \ubd84\uc11d\ud588\uc2b5\ub2c8\ub2e4. Dox \ubaa8\ub378 \uadf8\ub8f9\uacfc \ube44\uad50\ud558\uc5ec, \ube0c\ub808\ube44\uc2a4\uce74\ud540 \uce58\ub8cc \uadf8\ub8f9\uc758 \uc2ec\uadfc ATP \uc0dd\uc0b0\uc740 \uc720\uc758\ud558\uac8c \uc99d\uac00\ud588\uc2b5\ub2c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F5\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 5A<\/a>), FAO\uc758 \ub300\uc0ac\uc0b0\ubb3c\uc778 ROS\uc640 MDA\uc758 \uc218\uc900\uc740 \ud06c\uac8c \uac10\uc18c\ud588\uc2b5\ub2c8\ub2e4(<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F5\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 5B,E<\/a>). O2K \uc5d0\ub108\uc9c0 \ub300\uc0ac \ubd84\uc11d\uc5d0\uc11c\ub294 \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc774 Dox \ub178\ucd9c\ub85c \uc778\ud55c \uc2ec\uc7a5 \uc0b0\uc18c \uc18c\ube44\uc758 \uadf9\uc801\uc778 \uc99d\uac00\ub97c \uc5b5\uc81c\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F5\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 5C<\/a>), ATP \uc0dd\uc0b0\/\uc0b0\uc18c \uc18c\ube44 \ube44\uc728\uc774 \ud06c\uac8c \uac10\uc18c\ud588\uc2b5\ub2c8\ub2e4(<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F5\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 5D<\/a>), \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ub9c9 \uc804\uc704\ub97c \ud45c\uc900\ud654\ud588\uc2b5\ub2c8\ub2e4 (<a class=\"sec\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#s11\">\ubcf4\ucda9 \uadf8\ub9bc S4<\/a>). \uc774\ub294 \ube0c\ub808\ube44\uc2a4\uce74\ud540 \uce58\ub8cc\uac00 \uace0\uc5d0\ub108\uc9c0 \ud6a8\uc728\uc758 \ud3ec\ub3c4\ub2f9\uc744 \uc5d0\ub108\uc9c0\uc6d0\uc73c\ub85c \uc0ac\uc6a9\ud558\ub294 \uc2ec\uadfc\uc758 \ub2a5\ub825\uc744 \uc99d\uac00\uc2dc\ud0a8\ub2e4\ub294 \uac83\uc744 \uc758\ubbf8\ud569\ub2c8\ub2e4. ATP \uc0dd\uc0b0 \ud6a8\uc728\uc131\uc744 \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \uc2ec\uc7a5 \ubd80\ud558, \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4 \ubc0f \uc2ec\uadfc \uc0b0\uc18c \uc18c\ube44\ub97c \uc904\uc785\ub2c8\ub2e4. \uacb0\ub860\uc801\uc73c\ub85c, \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc740 \uc138\ub85c\ud1a0\ub2cc-\ud608\ub2f9-\uc2ec\uadfc AKT \ub8e8\ud504\ub97c \uc870\uc808\ud558\uace0 \uc2ec\uadfc \uc5d0\ub108\uc9c0 \ub300\uc0ac\ub97c \ub9ac\ubaa8\ub378\ub9c1\ud558\uba70 \ud3ec\ub3c4\ub2f9 \ud65c\uc6a9\uc744 \uc99d\uac00\uc2dc\ud0a4\uace0 FAO\ub97c \uac10\uc18c\uc2dc\ud0b4\uc73c\ub85c\uc368 Dox \ub178\ucd9c\ub85c \uc778\ud55c \uc2ec\uc7a5\uc758 \ub192\uc740 \uc0b0\uc18c \uc18c\ube44\uc728\uacfc \ubd80\uc801\uc808\ud55c \uc9c0\uc9c8 \uc5f0\uc18c\uc758 \uc545\uc21c\ud658\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \ub04a\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4. (<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F5\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 5F<\/a>), DIC\uc758 \ucd94\uac00 \uac1c\ubc1c\uc744 \ubc29\ud574\ud569\ub2c8\ub2e4.<\/p>\n<div id=\"F5\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm139983197130224\">\n<div class=\"ts_bar small\" title=\"\ud655\ub300\ud558\ub824\uba74 \uc774\ubbf8\uc9c0\ub97c \ud074\ub9ad\ud558\uc138\uc694.\"><\/div>\n<p><a class=\"inline_block ts_canvas\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/core\/lw\/2.0\/html\/tileshop_pmc\/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&amp;p=PMC3&amp;id=9551275_fphar-13-930835-g005.jpg\" target=\"tileshopwindow\" rel=\"noopener\"><img decoding=\"async\" class=\"tileshop\" title=\"\ud655\ub300\ud558\ub824\uba74 \uc774\ubbf8\uc9c0\ub97c \ud074\ub9ad\ud558\uc138\uc694.\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/bin\/fphar-13-930835-g005.jpg\" alt=\"An external file that holds a picture, illustration, etc.Object name is fphar-13-930835-g005.jpg\" \/><\/a><\/div>\n<div id=\"lgnd_F5\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F5\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 5<\/a><\/div>\n<div class=\"caption\">\n<p><strong>(\u314f)<\/strong>\u00a0H9c2 \uc138\ud3ec\uc758 ATP \ud568\ub7c9.\u00a0<strong>(\ube44)<\/strong>\u00a0H9c2 \uc138\ud3ec\uc758 MDA \ud568\ub7c9.\u00a0<strong>(\uc528)<\/strong>\u00a0H9c2 \uc138\ud3ec\uc758 \uc2ec\uc7a5 \uc0b0\uc18c \uc18c\ube44\ub7c9.\u00a0<strong>(\ub514)<\/strong>\u00a0H9c2 \uc138\ud3ec\uc758 ATP \uc0dd\uc0b0\/\uc0b0\uc18c \uc18c\ube44 \ube44\uc728.\u00a0<strong>(\uc774\uc790\ud615)<\/strong>\u00a0H9c2 \uc138\ud3ec\uc5d0\uc11c ROS \uc5fc\uc0c9\uc758 \uac15\ub3c4.\u00a0<strong>(\uc5d0\ud504)<\/strong>\u00a0\uac1c\ub7b5\ub3c4. \ucee8\ud2b8\ub864 \ub300 Dox, Brev \ub300 Dox, Dexra \ub300 Dox: ***<em>\ud53c<\/em>\u00a0&lt; 0.0005, **<em>\ud53c<\/em>\u00a0&lt; 0.005, *<em>\ud53c<\/em>\u00a0&lt; 0.05, \ud3c9\uade0 \u00b1 SD.\u00a0<em>N<\/em>\u00a0= 6\u20139.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"s3-5\" class=\"sec\">\n<h3 id=\"s3-5title\">Breviscapine\uc740 PINK1\/Parkin \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\ub97c \ud1b5\ud574 Dox \uce58\ub8cc \ud6c4 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc190\uc0c1\uc744 \uc81c\uac70\ud558\uace0 \uc2ec\uadfc \ud56d\uc0c1\uc131\uc744 \ud68c\ubcf5\ud569\ub2c8\ub2e4.<\/h3>\n<p class=\"p p-first\">DIC\uc758 \uba54\ucee4\ub2c8\uc998\uc5d0 \uad00\ud55c \uac00\uc124\uc740 \uc9c0\ub09c \uc218\uc2ed \ub144 \ub3d9\uc548 \ub2e4\uc591\ud588\uc9c0\ub9cc DIC\uc758 \uc8fc\uc694 \ud2b9\uc9d5\uc740 \uc0b0\ud654\ud658\uc6d0 \ubd88\uade0\ud615\uacfc \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5 \uc190\uc0c1\uc785\ub2c8\ub2e4. \uacb0\uacfc\ub294 \uc774\uc804\uc5d0 \uc2ec\uc7a5 \uc5d0\ub108\uc9c0 \ube44\uc728\uacfc \uc5d0\ub108\uc9c0 \ucd9c\ub825 \ud6a8\uc728\uc131\uc758 \uad00\uc810\uc5d0\uc11c DIC \uac1c\ubc1c \uac00\uc124\uc744 \uac1c\uc120\ud558\ub294 \uac83\uc744 \ubc29\ud574\ud588\uc9c0\ub9cc \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc774 \uc5b4\ub5bb\uac8c \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc774\ud6c4 \uc2ec\uc7a5\uc758 \ub300\uc0ac \ub124\ud2b8\uc6cc\ud06c\ub97c \ucd5c\uc801\ud654\ud558\uc5ec \ud6a8\uc728\uc801\uc778 \uc5d0\ub108\uc9c0 \uc0dd\uc0b0\uacfc \uc2ec\uc7a5 \ubbf8\uc138\ud658\uacbd \ud56d\uc0c1\uc131\uc744 \ub2ec\uc131\ud558\ub294\uc9c0\uc5d0 \ub300\ud55c \uc911\uc694\ud55c \uc9c8\ubb38\uc744 \uc81c\uae30\ud569\ub2c8\ub2e4. \ubd80\uc0c1. \ub530\ub77c\uc11c \uc6b0\ub9ac\ub294 \uc774 \uc9c8\ubb38\uc5d0 \ub2f5\ud558\ub294 \uac83\uc744 \ubaa9\ud45c\ub85c \uc0bc\uc558\uc2b5\ub2c8\ub2e4. Pten\uc5d0 \uc758\ud574 \uc720\ub3c4\ub41c \ucd94\uc815 \ud0a4\ub098\uc544\uc81c1 PINK1\/Parkin \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\ub294 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc790\uac00\ud3ec\uc2dd\uc5d0 \uc758\ud574 \ub9e4\uac1c\ub418\ub294 \uc8fc\uc694 \uacbd\ub85c \uc911 \ud558\ub098\uc774\uba70 \uc2ec\uadfc\uc138\ud3ec\uc758 \uc5d0\ub108\uc9c0 \ub300\uc0ac\ub97c \uc720\uc9c0\ud558\ub294 \ub370 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B7\" aria-expanded=\"false\" aria-haspopup=\"true\">Dewanjee \uc678, 2021<\/a>). \uc2ec\uadfc\uc138\ud3ec\uc758 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uac00 \uc190\uc0c1\ub418\uba74 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ud488\uc9c8 \uad00\ub9ac \uc2dc\uc2a4\ud15c\uc758 &#039;\uac10\uc2dc\uc6d0&#039;\uc778 PINK1\uc774 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc678\ub9c9\uc5d0 \ucd95\uc801\ub418\uc5b4 \ud30c\ud0a8(Parkin)\uc744 \uc218\uc9d1\ud558\uace0 \uc778\uc0b0\ud654\uc2dc\ud0a8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B33\" aria-expanded=\"false\" aria-haspopup=\"true\">\ud480\uacfc \ub9e4\ud074\ub77c\uc6b0\ub4dc, 2021<\/a>). \ud65c\uc131\ud654\ub41c \ud30c\ud0a8\uc740 \uc190\uc0c1\ub41c \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\ub97c \uc720\ube44\ud034\ud2f4\ud654\ud55c \ub2e4\uc74c \ub9ac\uc18c\uc880\uacfc \uc735\ud569\ud558\uc5ec \ubd84\ud574\ub97c \uc644\ub8cc\ud569\ub2c8\ub2e4. PINK1\/Parkin \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\uc5d0 \uc758\ud574 \ub9e4\uac1c\ub418\ub294 \uac15\ud654\ub41c \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc790\uac00\ud3ec\uc2dd\uc740 \uc2ec\uadfc\uc138\ud3ec\uc758 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ud56d\uc0c1\uc131\uc744 \uc720\uc9c0\ud558\uace0 \uc2ec\uc7a5 \uc9c8\ud658\uc758 \uc9c4\ud589\uc744 \ub2a6\ucd9c \uc218 \uc788\uc2b5\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B8\" aria-expanded=\"false\" aria-haspopup=\"true\">\ub3c4\ub978, 2016<\/a>).<\/p>\n<p>\ub530\ub77c\uc11c \uc6b0\ub9ac\ub294 \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc774 PINK1\/Parkin \uacbd\ub85c\ub97c \ud1b5\ud574 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc790\uac00\ud3ec\uc2dd\uc744 \uac15\ud654\ud558\uace0 \uc2ec\uadfc\uc138\ud3ec\uc5d0\uc11c \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ud56d\uc0c1\uc131\uc744 \uc720\uc9c0\ud55c\ub2e4\uace0 \ucd94\uce21\ud588\uc2b5\ub2c8\ub2e4. WB\ub294 Dox \ud22c\uc5ec\uad70\uc5d0 \ube44\ud574 \ube0c\ub808\ube44\uc2a4\uce74\ud540 \ud22c\uc5ec\uad70\uc5d0\uc11c PINK1\/Parkin\uc758 \ucd1d \ub2e8\ubc31\uc9c8 \ubc1c\ud604 \uc218\uc900\uc774 \uc720\uc758\ud558\uac8c \uc99d\uac00\ud55c \uac83\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 6A<\/a>), \ud574\ub2f9 \uc778\uc0b0\ud654 \uc218\uc900\ub3c4 \ud06c\uac8c \uc99d\uac00\ud588\uc2b5\ub2c8\ub2e4(<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 6B<\/a>). Dox \ucc98\ub9ac\uad70\uc5d0\uc11c\ub294 PINK1\/Parkin \ub2e8\ubc31\uc9c8 \ubc1c\ud604\uc774 \uac10\uc18c\ud558\ub294 \uacbd\ud5a5\uc744 \ubcf4\uc600\uc73c\uba70, \ub2e8\ubc31\uc9c8 \uc778\uc0b0\ud654\uac00 \uc720\uc758\ud558\uac8c \uac10\uc18c\ud55c \ubc18\uba74, \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ub9c9 \ub2e8\ubc31\uc9c8 Tom20\uc758 \uc218\uc900\uc740 \uc99d\uac00\ud558\uc5ec Dox\uac00 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc190\uc0c1\uc744 \uc720\ubc1c\ud558\ub354\ub77c\ub3c4 \uc190\uc0c1\ub41c \ub2e8\ubc31\uc9c8\uc758 \uc801\uc2dc \uc81c\uac70\ub97c \uc5b5\uc81c\ud568\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544. Dox \uadf8\ub8f9\uc5d0\uc11c\ub294 \ub2e4\uc218\uc758 \ubd80\uc11c\uc9c0\uace0 \uc190\uc0c1\ub41c \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uac00 \uad00\ucc30\ub418\uc5c8\uc2b5\ub2c8\ub2e4(\ube68\uac04\uc0c9 \ud654\uc0b4\ud45c,\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 6D<\/a>), Brev \uadf8\ub8f9\uc5d0\uc11c\ub294 \ub2e4\ub7c9\uc758 \ub9ac\uc18c\uc880\uc73c\ub85c \ub458\ub7ec\uc2f8\uc778 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc790\uac00\ud3ec\uc2dd\uc774 \uad00\ucc30\ub418\uc5c8\uc2b5\ub2c8\ub2e4(\ud30c\ub780\uc0c9 \ud654\uc0b4\ud45c). Dox\uc640 Brev\ub97c \ub3d9\uc2dc\uc5d0 \uc801\uc6a9\ud55c \uacbd\uc6b0 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ub2a5\uc120\uc774 \ub69c\ub837\ud558\uace0 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ud615\ud0dc\uac00 \uc815\uc0c1\uc774\uba70 \ub9c9 \uad6c\uc870\uac00 \uc190\uc0c1\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. MitoTracker\ub85c \uc5fc\uc0c9\ud588\uc744 \ub54c Dox \uadf8\ub8f9\uc5d0\uc11c \uac00\uc7a5 \ub192\uc740 \ud615\uad11 \uac15\ub3c4\uac00 \ubc1c\uacac\ub418\uc5c8\uc2b5\ub2c8\ub2e4(<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 6C<\/a>), \uc774\ub294 \ub300\uc870\uad70\uacfc Brev \uadf8\ub8f9\ubcf4\ub2e4 Dox \uadf8\ub8f9\uc5d0 \ud6e8\uc52c \ub354 \ub9ce\uc740 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uac00 \uc788\uc74c\uc744 \ub098\ud0c0\ub0c5\ub2c8\ub2e4. \ub354\uc6b1\uc774, \ud56d\uc0b0\ud654 \ub2e8\ubc31\uc9c8\uc778 NADH\uc640 SOD\uc758 \uc218\uc900\uc740 Brev \uce58\ub8cc \ud6c4\uc5d0 \uc720\uc758\ud558\uac8c \uc99d\uac00\ud588\uc2b5\ub2c8\ub2e4.<a class=\"sec\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#s11\">\ubcf4\ucda9 \uadf8\ub9bc S5<\/a>). \uc5d0\ub108\uc9c0 \uc218\uc6a9\uccb4 AMPK\uc758 \uc778\uc0b0\ud654\ub294 Dox \uadf8\ub8f9\uc5d0 \ube44\ud574 Brev \uce58\ub8cc \uadf8\ub8f9\uc5d0\uc11c \ud06c\uac8c \uac10\uc18c\ud55c \ubc18\uba74, \uc138\ud3ec \uc131\uc7a5 \uc870\uc808 \uc13c\ud130\ub294 \ud65c\uc131\ud654\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 6E<\/a>). \uc774\ub7ec\ud55c \uacb0\uacfc\ub294 Dox \ub178\ucd9c\uc774 \uc2ec\uadfc \uc190\uc0c1, \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ucd95\uc801 \ubc0f \ud56d\uc0c1\uc131 \ubd88\uade0\ud615\uc744 \uc720\ubc1c\ud55c\ub2e4\ub294 \uac83\uc744 \ub098\ud0c0\ub0b4\uba70, \uc774\ub294 Dox \ud22c\uc5ec \ud6c4 \uc2ec\uc7a5 \uc5d0\ub108\uc9c0 \ucd9c\ub825 \ud6a8\uc728\uc774 \uac10\uc18c\ud558\uace0 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\uac00 \uc99d\uac00\ud558\ub294 \uc774\uc720\ub97c \uc5b4\ub290 \uc815\ub3c4 \uc124\uba85\ud569\ub2c8\ub2e4. \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc740 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc790\uac00\ud3ec\uc2dd\uc744 \ucd09\uc9c4\ud558\uace0, \uc190\uc0c1\ub41c \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\ub97c \uc81c\uac70\ud558\uba70, \uc2ec\uadfc \ud56d\uc0c1\uc131\uc744 \ud68c\ubcf5\ud558\uc5ec \uc2ec\uc7a5 ATP \uc0dd\uc0b0\uacfc \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4 \uc0ac\uc774\uc758 \ub3d9\uc801 \uade0\ud615\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \ubcf4\uc7a5\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<div id=\"F6\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm139983210526288\">\n<div class=\"ts_bar small\" title=\"\ud655\ub300\ud558\ub824\uba74 \uc774\ubbf8\uc9c0\ub97c \ud074\ub9ad\ud558\uc138\uc694.\"><\/div>\n<p><a class=\"inline_block ts_canvas\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/core\/lw\/2.0\/html\/tileshop_pmc\/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&amp;p=PMC3&amp;id=9551275_fphar-13-930835-g006.jpg\" target=\"tileshopwindow\" rel=\"noopener\"><img decoding=\"async\" class=\"tileshop\" title=\"\ud655\ub300\ud558\ub824\uba74 \uc774\ubbf8\uc9c0\ub97c \ud074\ub9ad\ud558\uc138\uc694.\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/bin\/fphar-13-930835-g006.jpg\" alt=\"An external file that holds a picture, illustration, etc.Object name is fphar-13-930835-g006.jpg\" \/><\/a><\/div>\n<div id=\"lgnd_F6\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 6<\/a><\/div>\n<div class=\"caption\">\n<p><strong>(\u314f)<\/strong>\u00a0PINK1, Parkin, Tom20 \ubc0f GAPDH\uc758 \ubc1c\ud604 \uc218\uc900\uc744 \uce21\uc815\ud588\uc2b5\ub2c8\ub2e4.\u00a0<em>\uc2dc\ud5d8\uad00 \ub0b4\uc5d0\uc11c<\/em>\u00a0WB\ub85c.\u00a0<strong>(\ube44)<\/strong>\u00a0p-PINK1, p-Parkin \ubc0f Tom20\uc758 \ubc1c\ud604 \uc218\uc900\uc744 \ud3c9\uac00\ud588\uc2b5\ub2c8\ub2e4.\u00a0<strong>(\uc528)<\/strong>\u00a0\ubbf8\ud1a0\ud2b8\ub808\uc774\uc11c \uc5fc\uc0c9.\u00a0<strong>(\ub514)<\/strong>\u00a0\uc804\uc790\ud604\ubbf8\uacbd.\u00a0<strong>(\uc774\uc790\ud615)<\/strong>\u00a0p-AMPK, p-mTOR, p-Akt \ubc0f p-PI3K\uc758 \ubc1c\ud604 \uc218\uc900\uc744 \ud3c9\uac00\ud588\uc2b5\ub2c8\ub2e4.\u00a0<strong>(\uc5d0\ud504)<\/strong>\u00a0Mdivi-1 \ubcf4\ucda9 \ud6c4 H9c2 \uc138\ud3ec\uc5d0\uc11c ROS \uc5fc\uc0c9 \uac15\ub3c4.\u00a0<strong>(G)<\/strong>\u00a0Mdivi-1 \ubcf4\ucda9 \ud6c4 H9c2 \uc138\ud3ec\uc758 ATP \ud568\ub7c9.<strong>(\uc2dc\uac04)<\/strong>\u00a0p-AMPK\/t-AMPK, p-mTOR\/t-mTOR, p-Akt\/t-Akt \ubc0f p-PI3K\/t-PI3K\uc758 \ub9c9\ub300 \uadf8\ub798\ud504\uc785\ub2c8\ub2e4. Control \ub300 Dox, Dox + Mdivi-1 \ub300 Dox, Dox + Brev + Mdivi-1 \ub300 Dox + Brev: ***<em>\ud53c<\/em>\u00a0&lt; 0.0005, **<em>\ud53c<\/em>\u00a0&lt; 0.005, *<em>\ud53c<\/em>\u00a0&lt; 0.05, \ud3c9\uade0 \u00b1 SD.\u00a0<em>N<\/em>\u00a0= 6\u20139.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p class=\"p p-last\">\ube0c\ub808\ube44\uc2a4\uce74\ud540\uc758 \uc774\ub7ec\ud55c \ud6a8\uacfc\uac00 Mdivi-1\uc5d0 \uc758\ud574 \ucc28\ub2e8\ub418\uc5c8\uc744 \ub54c \uc2ec\uadfc\uc138\ud3ec\uc758 ROS \uc218\uc900\uc774 \ud06c\uac8c \uc99d\uac00\ud588\uc2b5\ub2c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 6F<\/a>), ATP \uc0dd\uc0b0\ub7c9\uc774 \ud06c\uac8c \uac10\uc18c\ud55c \ubc18\uba74(<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 6G<\/a>). \ub610\ud55c \uc2ec\uadfc\uc138\ud3ec\uc758 \uc0dd\uc874\uc728\ub3c4 \uac10\uc18c\ud558\uc600\ub2e4(<a class=\"sec\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#s11\">\ubcf4\ucda9 \uadf8\ub9bc S6<\/a>), \uc2ec\uadfc\uc138\ud3ec\uc5d0 \ub300\ud55c \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc758 \ud68c\ubcf5 \ud6a8\uacfc\uac00 \uc5b5\uc81c\ub418\uc5c8\uc2b5\ub2c8\ub2e4. Dox\uc640 Mdivi-1\uc744 \uacb0\ud569\ud558\uba74 ATP \uc0dd\uc0b0\uacfc \uc2ec\uadfc\uc138\ud3ec\uc758 \uc0dd\uc874\uc728\uc774 \ub354\uc6b1 \uac10\uc18c\ud558\uace0 ROS \uc218\uc900\uc774 \uc99d\uac00\ud558\uba70 \uc2ec\uadfc \uc190\uc0c1\uc774 \uc545\ud654\ub429\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uacb0\uacfc\ub294 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc790\uac00\ud3ec\uc2dd\uc774 Dox \uc720\ubc1c \uc2ec\uadfc\uc138\ud3ec \uc190\uc0c1\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud55c\ub2e4\ub294 \uac83\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. \uc2ec\uc7a5\uc758 \ub300\uc0ac \ub124\ud2b8\uc6cc\ud06c \ub9ac\ubaa8\ub378\ub9c1\ub9cc\uc73c\ub85c\ub294 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc190\uc0c1\uc73c\ub85c \uc778\ud55c \uae30\ub2a5 \uc7a5\uc560\ub97c \uc644\uc804\ud788 \uc0c1\uc1c4\ud560 \uc218 \uc5c6\uc73c\uba70, \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc758 \uc2ec\uadfc \ubcf4\ud638 \ud6a8\uacfc\ub294 \ud3ec\ub3c4\ub2f9 \ubc0f \uc9c0\uc9c8 \ub300\uc0ac \uc870\uc808\uacfc \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc790\uac00\ud3ec\uc2dd \ud65c\uc131\ud654\uc5d0 \ub2ec\ub824 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub294 \ub610\ud55c DIC \ubc1c\ub2ec \uac00\uc124\uacfc \uad00\ub828\ud558\uc5ec \uc2ec\uc7a5 \ub300\uc0ac \ub124\ud2b8\uc6cc\ud06c\uc758 \uc870\uc808\uc774 \uace0\ub824\ub418\uc9c0 \uc54a\uc740 \uc774\uc720\uc77c \uc218\ub3c4 \uc788\uc2b5\ub2c8\ub2e4. Dox\ub85c \uc778\ud55c \uc2ec\uc7a5 \uae30\ub2a5 \uc7a5\uc560 \ubc0f \uc2ec\ubd80\uc804 \uc99d\uc0c1\uc758 \uce58\ub8cc\uc5d0\uc11c\ub294 \uc9c8\ubcd1\uc758 \uc9c4\ud589\uc744 \uc608\ubc29\ud558\uace0 \uc2ec\uc7a5 \uae30\ub2a5\uc744 \ud68c\ubcf5\ud558\ub294 \uac83\uc774 \ub611\uac19\uc774 \uc911\uc694\ud574\uc57c \ud658\uc790\uc758 \uc608\ud6c4\uc640 \uc0b6\uc758 \uc9c8\uc5d0 \ub354 \uc720\uc775\ud560 \uac83\uc73c\ub85c \uc81c\uc548\ub429\ub2c8\ub2e4.<\/p>\n<\/div>\n<div id=\"s3-6\" class=\"sec sec-last\">\n<h3 id=\"s3-6title\">Breviscapine\uc740 Dox \ud22c\uc5ec \ud6c4 \uc5fc\uc99d\uc744 \uc644\ud654\ud558\uace0 \uba74\uc5ed\uc5b5\uc81c \uc138\ud3ec \uce68\uc724\uc744 \uac10\uc18c\uc2dc\ucf1c \uc720\ubc29\uc554 \ud654\ud559\uc694\ubc95\uacfc \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub97c \ubc1c\ud718\ud569\ub2c8\ub2e4.<\/h3>\n<p class=\"p p-first\">\ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\uc6d0 \uc774\ub860\uc5d0 \ub530\ub974\uba74, \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\ub294 \ud638\uae30\uc131 \ubc15\ud14c\ub9ac\uc544\uc758 \uc735\ud569\uc5d0\uc11c \ud30c\uc0dd\ub418\ub294\ub370, \uc774\ub294 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uac00 \uc678\ubd80 \ud2b9\uc131\uc744 \uac00\uc9c0\uace0 \uc788\uc74c\uc744 \uc758\ubbf8\ud569\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B11\" aria-expanded=\"false\" aria-haspopup=\"true\">\uadf8\ub808\uc774, 2012<\/a>). \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uac00 \uc190\uc0c1\ub418\uba74 \uc190\uc0c1 \uad00\ub828 \ubd84\uc790 \ud328\ud134(DAMP)\uc774 \uc720\ubc1c\ub418\uc5b4 \uc2e0\uccb4\uc758 \uba74\uc5ed \ubc18\uc751\uc774 \ud65c\uc131\ud654\ub429\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B49\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc70c\ud0a8\uc2a4 \uc678, 2017<\/a>). \ub530\ub77c\uc11c \uc6b0\ub9ac\ub294 \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc774 \uc190\uc0c1\ub41c \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uc758 \uc81c\uac70\ub97c \ucd09\uc9c4\ud558\uace0 \uc5fc\uc99d\uc744 \uc904\uc774\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub41c\ub2e4\ub294 \uac00\uc124\uc744 \uc138\uc6e0\uc2b5\ub2c8\ub2e4. \uacb0\uacfc\ub294 \uc5fc\uc99d\uc131 \uc0ac\uc774\ud1a0\uce74\uc778\uc778 \uc778\ud130\ub8e8\ud0a8-1\u03b2(IL-1\u03b2), IL-6 \ubc0f \uc885\uc591 \uad34\uc0ac \uc778\uc790 \u03b1(TNF-\u03b1)\uc758 \ud608\uccad \uc218\uc900\uc774 \ube0c\ub808\ube44\uc2a4\uce74\ud540 \uac1c\uc785 \ud6c4 \uc720\uc758\ud558\uac8c \uac10\uc18c\ud55c \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F7\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 7A<\/a>), \uc2ec\uc7a5 \uc870\uc9c1\uc758 \uba74\uc5ed\uc5fc\uc0c9\uc5d0\uc11c\ub294 IL-1\u03b2\uac00 \ub0ae\uc740 \uc218\uc900\uc73c\ub85c \ubc1c\ud604\ub418\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4(<a class=\"sec\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#s11\">\ubcf4\ucda9 \uadf8\ub9bc S7<\/a>). \uc774\ub7ec\ud55c \uacb0\uacfc\ub294 \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc774 \uc5fc\uc99d \uc778\uc790\uc758 \ubd84\ube44\ub97c \uac10\uc18c\uc2dc\ud0a4\uace0 Dox\uc5d0 \ub178\ucd9c\ub41c \uc0dd\uc950\uc5d0\uc11c \uc5fc\uc99d \ubc18\uc751\uc744 \uac10\uc18c\uc2dc\ud0ac \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. \uc5fc\uc99d \uc870\uc808 \uc778\uc790\uc640 \ud6a8\uacfc\uae30 \uc138\ud3ec\ub294 \uc885\uc591 \ubbf8\uc138 \ud658\uacbd\uc758 \uc911\uc694\ud55c \uad6c\uc131 \uc694\uc18c\uc774\uba70 \uc5fc\uc99d\uacfc \uc885\uc591 \uc0ac\uc774\uc758 \uad00\uacc4\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B9\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc5d8\ub9ac\ub098\ube0c \uc678, 2013<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B36\" aria-expanded=\"false\" aria-haspopup=\"true\">Sautes-Fridman \uc678, 2019<\/a>). \uc885\uc591 \ubbf8\uc138\ud658\uacbd\uc758 \uc5fc\uc99d\uc740 \uc545\uc131 \uc138\ud3ec\uc758 \uc99d\uc2dd\uacfc \uc0dd\uc874, \ud608\uad00 \uc2e0\uc0dd \ubc0f \uc804\uc774\ub97c \ucd09\uc9c4\ud560 \uc218 \uc788\ub294 \ub2e4\uc591\ud55c \uc885\uc591 \ud6a8\uacfc\ub97c \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc2e0\uccb4\uc758 \ud68d\ub4dd \uba74\uc5ed \ubc18\uc751\uc744 \uc57d\ud654\uc2dc\ud0b5\ub2c8\ub2e4. \ud638\ub974\ubaac\uacfc \ud654\ud559\uc694\ubc95 \uc57d\ubb3c\uc5d0 \ub300\ud55c \uc2e0\uccb4\uc758 \ubc18\uc751\uc744 \ubcc0\ud654\uc2dc\ud0b5\ub2c8\ub2e4(<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B14\" aria-expanded=\"false\" aria-haspopup=\"true\">Iyengar \uc678, 2016<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B28\" aria-expanded=\"false\" aria-haspopup=\"true\">\uba3c \uc564 \uba5c\ub7ec, 2016<\/a>). Breviscapine\uc740 Dox \uce58\ub8cc \ud6c4 \uc5fc\uc99d\uc744 \uac10\uc18c\uc2dc\ucf30\uc9c0\ub9cc \uc720\ubc29\uc554 \uc138\ud3ec\uc5d0 \ub300\ud55c Dox\uc758 \uc0ac\uba78 \ud6a8\uacfc\uc5d0\ub294 \uc601\ud5a5\uc744 \ubbf8\uce58\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4.\u00a0<em>\uc2dc\ud5d8\uad00 \ub0b4\uc5d0\uc11c<\/em>\u00a0(<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F7\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 7B<\/a>). \ud2b9\ud788 \uc885\uc591 \uad00\ub828 \ub300\uc2dd\uc138\ud3ec(TAM)\uc758 \ud611\ub825 \uce58\ub8cc\uc5d0\uc11c \uc5fc\uc99d \uc138\ud3ec\uac00 \uc885\uc591 \ucd08\uc810\uc73c\ub85c \uc774\ub3d9\ud558\ub294 \uac83\uc744 \ubc29\uc9c0\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub420 \uc218 \uc788\ub294\uc9c0 \uc5ec\ubd80\ub294 \ubd88\ubd84\uba85\ud569\ub2c8\ub2e4. TAM\uc740 \uc911\uc694\ud55c \uce68\ud22c \uba74\uc5ed \uc138\ud3ec\uc774\uba70 \uc720\ubc29\uc554\uc5d0\uc11c \uc885\uc591 \uc138\ud3ec\uc758 50%\ub97c \uc124\uba85\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub9c8\uc6b0\uc2a4\uc640 \uc778\uac04 \uc885\uc591\uc758 TAM \ubc0f \uad00\ub828 \uc138\ud3ec\ub294 \uc77c\ubc18\uc801\uc73c\ub85c M2 \ub300\uc2dd\uc138\ud3ec\uc774\uba70, \uc774\ub294 \uc885\uc591 \uc131\uc7a5 \ubc0f \ud608\uad00\uc2e0\uc0dd\uc744 \ucd09\uc9c4\ud558\uace0 \uce58\ub8cc \uc800\ud56d\uc131\uc744 \uac15\ud654\ud558\uba70 \ud68d\ub4dd \uba74\uc5ed\uc744 \uc5b5\uc81c\ud569\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B6\" aria-expanded=\"false\" aria-haspopup=\"true\">\uccb8 \uc678, 2019<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B32\" aria-expanded=\"false\" aria-haspopup=\"true\">\ud32c \uc678., 2020<\/a>). TAM \uce68\ud22c \ub610\ub294 \uc57d\ubb3c\uc5d0 \uc758\ud55c TAM \uc81c\uac70\ub97c \uc904\uc774\ub294 \uac83\uc740 \uc885\uc591 \uba74\uc5ed\uc694\ubc95\uc744 \uc704\ud55c \uc0c8\ub85c\uc6b4 \uc804\ub7b5\uc785\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc6b0\ub9ac\ub294 4T1 \uc720\ubc29\uc554 \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc744 \uad6c\ucd95\ud588\uc2b5\ub2c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F7\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 7C<\/a>). 4T1 \uc885\uc591\uc774 \uc788\ub294 \uc950\u00a0<em>\ud604\uc7a5\uc5d0\uc11c<\/em>\u00a0(200mm<sup>3<\/sup>)\ub97c \ubb34\uc791\uc704\ub85c 3\uac1c \uadf8\ub8f9\uc73c\ub85c \ub098\ub204\uc5c8\uc2b5\ub2c8\ub2e4(<em>N<\/em>\u00a0= 5) \uc778\uc0b0\uc5fc \uc644\ucda9 \uc2dd\uc5fc\uc218(PBS), Dox \ub610\ub294 Dox + Brev\ub97c \uc8fc\uc785\ud588\uc2b5\ub2c8\ub2e4. Dox\uc640 Brev\ub294 10mgkg\uc758 \uc6a9\ub7c9\uc73c\ub85c \ud22c\uc5ec\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<sup>-1<\/sup>\u00a0\uccb4\uc911 \ubc0f 1.4 mgkg<sup>-1<\/sup>\u00a0\uccb4\uc911\uc740 \uac01\uac01. \uce58\ub8cc 7\uc77c \ud6c4 \ub9c8\uc6b0\uc2a4\ub97c \ud76c\uc0dd\uc2dc\ud0a4\uace0, FCM \ubc0f \uc870\uc9c1\ud559\uc801 \ud3c9\uac00\ub97c \uc704\ud574 \uc885\uc591\uc744 \uc218\uc9d1\ud558\uc600\ub2e4. Dox + Brev \uce58\ub8cc \ud6c4 \uc885\uc591\uc5d0 \uce68\ud22c\ud558\ub294 \uc885\uc591 \uad00\ub828 \ub300\uc2dd\uc138\ud3ec(TAM)\uc758 \ube44\uc728\uc774 \uac10\uc18c\ud588\uc2b5\ub2c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F7\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 7D<\/a>). \uc885\uc591 \uc870\uc9c1\uc758 \uc870\uc9c1\ud559\uc801 \uc5fc\uc0c9\uc5d0\uc11c\ub294 M2 \ud45c\ud604\ud615 \ud45c\uc9c0\uc790 CD206\uc758 \ubc1c\ud604\uc774 \ud604\uc800\ud788 \ub0ae\uc740 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F7\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 7E<\/a>). Dox + Brev\ub85c \ucc98\ub9ac\ud55c \uc950\uc758 \uc885\uc591 \ubd80\ud53c\ub294 Dox \ub2e8\ub3c5\uc73c\ub85c \ucc98\ub9ac\ud55c \uc950\uc758 \uc885\uc591 \ubd80\ud53c\ubcf4\ub2e4 \ud604\uc800\ud788 \ub0ae\uc558\uc2b5\ub2c8\ub2e4.<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F7\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 7F<\/a>), \uc774\ub294 \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc774 \uc5fc\uc99d\uacfc TAM \uce68\uc724\uc744 \uac10\uc18c\uc2dc\ucf1c \uc885\uc591 \uc131\uc7a5\uc744 \uc5b5\uc81c\ud560 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4.<\/p>\n<div id=\"F7\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm139983202323296\">\n<div class=\"ts_bar small\" title=\"\ud655\ub300\ud558\ub824\uba74 \uc774\ubbf8\uc9c0\ub97c \ud074\ub9ad\ud558\uc138\uc694.\"><\/div>\n<p><a class=\"inline_block ts_canvas\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/core\/lw\/2.0\/html\/tileshop_pmc\/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&amp;p=PMC3&amp;id=9551275_fphar-13-930835-g007.jpg\" target=\"tileshopwindow\" rel=\"noopener\"><img decoding=\"async\" class=\"tileshop\" title=\"\ud655\ub300\ud558\ub824\uba74 \uc774\ubbf8\uc9c0\ub97c \ud074\ub9ad\ud558\uc138\uc694.\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/bin\/fphar-13-930835-g007.jpg\" alt=\"An external file that holds a picture, illustration, etc.Object name is fphar-13-930835-g007.jpg\" \/><\/a><\/div>\n<div id=\"lgnd_F7\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F7\/\" target=\"figure\" rel=\"noopener\">\uadf8\ub9bc 7<\/a><\/div>\n<div class=\"caption\">\n<p><strong>(\u314f)<\/strong>\u00a0\uc5fc\uc99d\uc131 \uc0ac\uc774\ud1a0\uce74\uc778 IL-1\u03b2, IL-6 \ubc0f TNF-\u03b1\uc758 \ud608\uccad \uc218\uc900.\u00a0<strong>(\ube44)<\/strong>\u00a0MCF-7 \uc138\ud3ec \uc0dd\uc874\ub825\u00a0<em>\uc2dc\ud5d8\uad00 \ub0b4\uc5d0\uc11c<\/em>.\u00a0<strong>(\uc528)<\/strong>\u00a0\uc885\uc591\uc774 \uc788\ub294 \uc950\uc758 \uce58\ub8cc\uc5d0 \ub300\ud55c \ub3c4\uc2dd\uc801 \ud504\ub85c\ud1a0\ucf5c.\u00a0<strong>(\ub514)<\/strong>\u00a0FCM\uc744 \uc704\ud574 \ub9c8\uc6b0\uc2a4 \uc885\uc591\uc744 \uc218\uc9d1\ud588\uc2b5\ub2c8\ub2e4.\u00a0<strong>(\uc774\uc790\ud615)<\/strong>\u00a0M2 \ud45c\ud604\ud615 \ub9c8\ucee4 CD206\uc5d0 \ub300\ud55c \uc885\uc591\uc758 \uc870\uc9c1\ud559\uc801 \uc5fc\uc0c9.\u00a0<strong>(\uc5d0\ud504)<\/strong>\u00a0\ucd1d \uc885\uc591 \ubd80\ub2f4\uc758 \ud3c9\uade0\uc785\ub2c8\ub2e4. *<em>\ud53c<\/em>\u00a0&lt; 0.0005. \ucee8\ud2b8\ub864 \ub300 Dox, Dexra \ub300 Dox, Brev \ub300 Dox: ***<em>\ud53c<\/em>\u00a0&lt; 0.0005, **<em>\ud53c<\/em>\u00a0&lt; 0.005, *<em>\ud53c<\/em>\u00a0&lt; 0.05, \ud3c9\uade0 \u00b1 SD.\u00a0<em>N<\/em>\u00a0= 6\u20139.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"s4\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\uc774 \ud398\uc774\uc9c0\uc758 \ub2e4\ub978 \uc139\uc158\uc73c\ub85c \uc774\ub3d9\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc774\ub3d9 :<\/a><\/div>\n<h2 id=\"s4title\" class=\"head no_bottom_margin ui-helper-clearfix\">\ub17c\uc758<\/h2>\n<p class=\"p p-first\">\ubcf8 \uc5f0\uad6c\ub294 \ud3ec\ub3c4\ub2f9 \ubc0f \uc9c0\uc9c8 \ub300\uc0ac \uae30\ub2a5 \uc7a5\uc560\uac00 \uc548\ud2b8\ub77c\uc0ac\uc774\ud074\ub9b0 \uc720\ubc1c \uc2ec\uc7a5 \ub3c5\uc131\uc758 \uc911\uc694\ud55c \uc6d0\ub3d9\ub825\uc784\uc744 \ubc1d\ud788\uace0, \uc2ec\uc7a5 \ub300\uc0ac \ud68c\ubcf5, \uc2ec\uadfc \ud3ec\ub3c4\ub2f9 \ub300\uc0ac \ucd09\uc9c4, \uc2ec\uadfc \uc5d0\ub108\uc9c0 \ucd9c\ub825 \ud6a8\uc728 \ud5a5\uc0c1\uc774 Dox\uc758 \uc2ec\uc7a5 \ubd80\uc791\uc6a9\uc744 \uc608\ubc29\ud558\ub294 \ud6a8\uacfc\uc801\uc778 \ubc29\ubc95\uc784\uc744 \ubc1d\ud799\ub2c8\ub2e4. \uc774\ub294 \uc190\uc0c1\ub41c \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\ub97c \uc81c\uac70\ud558\ub294 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc790\uac00\ud3ec\uc2dd\uc744 \ucd09\uc9c4\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc5fc\uc99d\uc744 \uac10\uc18c\uc2dc\ud0a4\uba74 Dox\uc758 \ud56d\uc554 \ud6a8\uacfc\uac00 \ud5a5\uc0c1\ub429\ub2c8\ub2e4.<\/p>\n<p>\ud3ec\uc720\ub958 \uc2ec\uc7a5\uc740 \uc9c0\uc18d\uc801\uc778 \uc218\ucd95\uc744 \uc704\ud574 \ub9ce\uc740 \uc591\uc758 \uc5d0\ub108\uc9c0\ub97c \uc0ac\uc6a9\ud558\uba70, ATP \uc0dd\uc0b0\uacfc \uc2ec\uc7a5 \uc218\ucd95 \uc0ac\uc774\uc758 \uae34\ubc00\ud55c \uacb0\ud569\uc740 \uc801\uc808\ud55c \uc2ec\uc7a5 \uae30\ub2a5\uc5d0 \ud544\uc218\uc801\uc785\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B3\" aria-expanded=\"false\" aria-haspopup=\"true\">\ubca0\ub974\ud14c\ub85c\uc640 \ub9c8\ud06c, 2018<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B44\" aria-expanded=\"false\" aria-haspopup=\"true\">\ud300 \uc678., 2018<\/a>). \uc774 \uacfc\uc815\uc5d0\ub294 \uc2ec\uc7a5 \uc5d0\ub108\uc9c0 \ub300\uc0ac \ub124\ud2b8\uc6cc\ud06c\uc758 \uc815\ud655\ud55c \uc870\uc808\uc774 \ud544\uc694\ud569\ub2c8\ub2e4. \uc774 \ub124\ud2b8\uc6cc\ud06c\uc758 \uac00\uc7a5 \ub208\uc5d0 \ub744\ub294 \ud2b9\uc9d5\uc740 \ubc1c\ub2ec \ubcc0\ud654 \ubc0f \uc601\uc591 \uc0c1\ud0dc\ub97c \ud3ec\ud568\ud55c \ub2e4\uc591\ud55c \uc790\uadf9\uc5d0 \ubc18\uc751\ud558\ub294 \ub300\uc0ac \uc720\uc5f0\uc131\uacfc \ub9cc\uc131 \ubcd1\ub9ac\uc0dd\ub9ac\ud559\uc801 \uc870\uac74\uc5d0\uc11c \uc2ec\uadfc \uc5d0\ub108\uc9c0 \ubc0f \uc218\ucd95\uae30 \uae30\ub2a5\uc744 \uc870\uc808\ud558\uae30 \uc704\ud574 \ub300\uc0ac \uacbd\ub85c\ub97c \uc7ac\uad6c\uc131\ud558\ub294 \uc2ec\uc7a5\uc758 \ub2a5\ub825\uc785\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B3\" aria-expanded=\"false\" aria-haspopup=\"true\">\ubca0\ub974\ud14c\ub85c\uc640 \ub9c8\ud06c, 2018<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B16\" aria-expanded=\"false\" aria-haspopup=\"true\">\uae40 \uc678, 2018<\/a>). \uc774\ub7ec\ud55c \ub300\uc0ac \ub9ac\ubaa8\ub378\ub9c1\uc740 \uc2ec\uc7a5 \uae30\ub2a5\uc758 \ubcf4\uc874\uc5d0 \uae30\uc5ec\ud558\uac70\ub098 \uc9c8\ubcd1\uc758 \uc9c4\ud589\uc744 \uac00\uc18d\ud654\ud569\ub2c8\ub2e4. \uc2ec\uc7a5\ube44\ub300\uc99d, \uc2ec\ubd80\uc804 \ub4f1 \uc2ec\uc7a5\uc9c8\ud658\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub294 \ub9ce\uc9c0\ub9cc DIC\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub294 \uac70\uc758 \uc5c6\uc5c8\ub2e4. \uc774\uc804 \uc5f0\uad6c\uc5d0\uc11c\ub294 ROS \uc0dd\uc0b0\uacfc \ud1a0\ud3ec\uc774\uc18c\uba38\ub77c\uc81c II-\u03b2 \ud45c\uc801\ud654\uc5d0 \uc911\uc810\uc744 \ub450\uc5b4 DNA \uc190\uc0c1, \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5 \uc7a5\uc560 \ubc0f Ca\ub97c \uc720\ubc1c\ud569\ub2c8\ub2e4.<sup>2+<\/sup>\u00a0\uc798\ubabb\ub41c \ucde8\uae09. \uadf8\ub7ec\ub098 ROS \uc81c\uac70 \ucca0 \ud0ac\ub808\uc774\ud2b8\uc81c\uc640 \ud1a0\ud3ec\uc774\uc18c\uba38\ub77c\uc81c II-\u03b2 \uc870\uc808\uc81c dexra\ub294 \uc0c1\ub2f9\ud55c \uc774\uc810\uc744 \uc81c\uacf5\ud558\uc9c0 \ubabb\ud558\uba70, \uc774\ub294 \ub2e4\ub978 \uc694\uc778\ub3c4 \uad00\ub828\ub418\uc5b4 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. Dox\uac00 \uc2ec\uadfc\uc758 \ub300\uc0ac \ub124\ud2b8\uc6cc\ud06c\ub97c \uc5b4\ub5bb\uac8c \uc870\uc808\ud558\ub294\uc9c0, \uc774 \ub300\uc0ac \ub124\ud2b8\uc6cc\ud06c\uc758 \ub9ac\ubaa8\ub378\ub9c1\uc774 \uc2ec\uc7a5\uc758 \uc5d0\ub108\uc9c0 \ucd9c\ub825 \ud6a8\uc728\uc5d0 \uc5b4\ub5bb\uac8c \uc601\ud5a5\uc744 \ubbf8\uce58\ub294\uc9c0, Dox\uac00 \uc2ec\uc7a5 \ub3c5\uc131\uc744 \ucd09\uc9c4\ud558\ub294\uc9c0 \uc5ec\ubd80\ub294 \uc544\uc9c1 \uc54c\ub824\uc9c0\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \ucd5c\uadfc \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \uc9c0\uc9c8 \uacfc\uc0b0\ud654 \ucd95\uc801\uc73c\ub85c \uc778\ud55c \uc2ec\uadfc\uc138\ud3ec\uc758 \ud398\ub86d\ud1a0\uc2dc\uc2a4(ferroptosis)\uac00 DIC\uc758 \uc9c4\ud589\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\uba70, \uc774\ub294 Dox\uc5d0 \ub178\ucd9c\ub41c \uc2ec\uadfc\uc138\ud3ec\uac00 \uc9c0\uc9c8 \ub300\uc0ac\ub97c \ud5a5\uc0c1\uc2dc\ud0a4\ub294 \uacbd\ud5a5\uc774 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B52\" aria-expanded=\"false\" aria-haspopup=\"true\">Xie \uc678, 2021<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B17\" aria-expanded=\"false\" aria-haspopup=\"true\">\ud0a4\ud0c0\uce74\ud0c0 \uc678, 2022<\/a>). \uc6b0\ub9ac\uc758 \uc5f0\uad6c \uacb0\uacfc\ub294 Dox\ub85c \uc778\ud55c \uc2ec\uc7a5 \ub3c5\uc131\uc774 \ud3ec\ub3c4\ub2f9\uacfc \uc9c0\uc9c8 \ub300\uc0ac \uc870\uc808 \uc7a5\uc560\uc758 \uc545\uc21c\ud658 \ub8e8\ud504\uc640 \uadf8\uc5d0 \ub530\ub978 \uc0b0\uc18c \uc18c\ube44 \uc99d\uac00, \ube44\ud6a8\uc728\uc801\uc778 \uc5d0\ub108\uc9c0 \uc0dd\uc0b0 \ubc0f \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4 \uc218\uc900 \uc99d\uac00\uc5d0 \uc758\ud574 \uc720\ubc1c\ub41c\ub2e4\ub294 \uac83\uc744 \ucd94\uac00\ub85c \uc124\uba85\ud569\ub2c8\ub2e4.<\/p>\n<p class=\"p p-last\">\ube0c\ub808\ube44\uc2a4\uce74\ud540(Breviscapine)\uc740 \uc911\uad6d\uc5d0\uc11c \uc2ec\ud608\uad00 \ubc0f \ub1cc\ud608\uad00 \uc9c8\ud658 \uce58\ub8cc\uc5d0 \uac00\uc7a5 \ub110\ub9ac \uc0ac\uc6a9\ub418\ub294 \uace0\uc804 \uc57d\ubb3c\uc774\uba70, \uc911\uad6d \uc57d\uc804 \ubc0f \uad6d\uac00 \ud544\uc218 \uc758\uc57d\ud488 \ubaa9\ub85d\uc5d0 \ud3ec\ud568\ub418\uc5b4 \uc788\uc73c\uba70 \uc911\uad6d \ubcd1\uc6d0\uc758 \uc751\uae09 \uce58\ub8cc\uc5d0 \ud544\uc218 \uc758\uc57d\ud488\uc785\ub2c8\ub2e4. \uc6b0\ub9ac \uc5f0\uad6c\uc5d0\uc11c\ub294 \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc774 \uc138\ub85c\ud1a0\ub2cc-\ud608\ub2f9-\uc2ec\uadfc AKT \ud68c\ub85c\ub97c \uc870\uc808\ud558\uace0, \uc2ec\uadfc \uc5d0\ub108\uc9c0 \ub300\uc0ac\ub97c \uc7ac\uad6c\uc131\ud558\uace0, \ud3ec\ub3c4\ub2f9 \ud65c\uc6a9\uc744 \uc99d\uac00\uc2dc\ud0a4\uace0, \uc9c0\uc9c8 \uc0b0\ud654\ub97c \uac10\uc18c\uc2dc\ud0b4\uc73c\ub85c\uc368 ATP \uc0dd\uc0b0 \ud6a8\uc728\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. Dox \ub178\ucd9c\ub85c \uc778\ud55c \uc2ec\uc7a5 \ub0b4 \ub2e4\ub7c9\uc758 \uc9c0\uc9c8 \ub300\uc0ac \ubd80\uc871\uc73c\ub85c \uc778\ud55c \ub0ae\uc740 ATP \uc0dd\uc0b0, \ub192\uc740 \uc0b0\uc18c \uc18c\ube44 \ubc0f \ub192\uc740 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub97c \uc644\ud654\ud558\uace0 AMPK\uc758 \ubc1c\ud604\uc744 \uac10\uc18c\uc2dc\ud0a4\uba70 \uc2ec\uc7a5\uc5d0\uc11c \uacfc\ub3c4\ud55c \uc9c0\uc9c8 \ud761\uc218\uc758 \uc545\uc21c\ud658\uc744 \ucc28\ub2e8\ud569\ub2c8\ub2e4. \uc2ec\uadfc\uc744 \uc57d\ud654\uc2dc\ud0a4\uace0 DIC\uc758 \ubc1c\ub2ec\uc744 \uc9c0\uc5f0\uc2dc\ud0b5\ub2c8\ub2e4(<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B19\" aria-expanded=\"false\" aria-haspopup=\"true\">\ucf5c\ube44\uce20(Kolwicz)\uc640 \ud2f0\uc548(Tian), 2011\ub144<\/a>). \ub610\ud55c, \uc6b0\ub9ac\uc758 \uacb0\uacfc\ub294 \uc138\ub85c\ud1a0\ub2cc\uc774 \ud608\ub2f9\uc744 \uc870\uc808\ud558\ub294 \uc778\uc290\ub9b0\uc758 \ubcf4\uc870 \ubd84\uc9c0 \uc5ed\ud560\uc744 \ud560 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud558\uba70, \uc774\ub294 \ubcd1\ub9ac\ud559\uc801 \uc0c1\ud0dc\uc5d0\uc11c \uc2ec\uc7a5 \ubc0f \uae30\ud0c0 \uc911\uc694\ud55c \uae30\uad00\uc5d0 \ud608\ub2f9\uc744 \uacf5\uae09\ud569\ub2c8\ub2e4. \uc138\ub85c\ud1a0\ub2cc\uc740 \ud608\ub2f9 \uc870\uc808\uc5d0 \ubaa8\uc21c\ub41c \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4. \ud55c\ud3b8\uc73c\ub85c\ub294 \uc778\uc290\ub9b0\uacfc \uc0c1\ud638\uc791\uc6a9\ud558\uc5ec \ud608\ub2f9 \uc218\uce58\ub97c \ub0ae\ucda5\ub2c8\ub2e4. \ubc18\uba74\uc5d0 \uac04\uacfc \uace8\uaca9\uadfc \uc774\uc678\uc758 \uc870\uc9c1\uc774 \ud3ec\ub3c4\ub2f9\uc744 \ud761\uc218\ud558\uace0 \ud608\ub2f9 \uc218\uce58\ub97c \ub192\uc774\uac8c \ub429\ub2c8\ub2e4. \uc774\ub294 \ube0c\ub808\ube44\uc2a4\uce74\ud540 \uce58\ub8cc \ub4f1\uc744 \ud1b5\ud574 \ub9d0\ucd08 \ud608\uccad \uc218\uce58\ub97c \ub0ae\ucd94\ub294 \uac83\uc774 \uc7a5\uae30\uc758 \ud3ec\ub3c4\ub2f9 \uc0ac\uc6a9\uc744 \ub3c4\uc6b8 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. \ub610\ud55c \uc2ec\uc7a5 \ub3c5\uc131\uc5d0 \ub300\ud55c \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc758 \uc5b5\uc81c \ud6a8\uacfc\ub294 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc790\uac00\ud3ec\uc2dd\uc758 \uac15\ud654\uc5d0 \ub2ec\ub824 \uc788\uc73c\uba70 \uc2ec\uc7a5 \ub300\uc0ac \ub9ac\ubaa8\ub378\ub9c1\ub9cc\uc73c\ub85c\ub294 Dox\ub85c \uc778\ud55c \uc2ec\uc7a5 \uc190\uc0c1\uc758 \ub9e5\ub77d\uc5d0\uc11c \ucd95\uc801\ub41c \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\ub97c \uc81c\uac70\ud560 \uc218 \uc5c6\uc2b5\ub2c8\ub2e4. \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc740 \uc790\uac00\ud3ec\uc2dd\uc744 \uc720\ub3c4\ud569\ub2c8\ub2e4\u00a0<em>\uc0dd\uccb4 \ub0b4<\/em>\u00a0PINK1\/Parkin \uacbd\ub85c\ub97c \ud1b5\ud574 \uc2ec\uadfc \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ud56d\uc0c1\uc131\uc744 \ud68c\ubcf5\ud558\uace0 \ub3c5\uc18c\ub8e8\ube44\uc2e0\uc73c\ub85c \uc778\ud55c \uc2ec\uc7a5 \ub3c5\uc131\uc744 \uc644\ud654\ud569\ub2c8\ub2e4. \uc790\uac00\ud3ec\uc2dd\uc758 \ud65c\uc131\ud654\uac00 \ub2e4\uc591\ud55c \uc9c8\ubcd1\uc758 \ubc1c\uc0dd \ubc0f \ubc1c\ub2ec\uc5d0 \uad00\uc5ec\ud55c\ub2e4\ub294 \uc810\uc744 \uace0\ub824\ud558\uba74, \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc740 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc790\uac00\ud3ec\uc2dd \uad00\ub828 \uc9c8\ud658\uc758 \ud6c4\ubcf4 \uc57d\ubb3c\uc774 \ub420 \uc218 \uc788\uc5b4 \uc784\uc0c1\uc801 \ud65c\uc6a9 \uac00\uce58\uac00 \ub9e4\uc6b0 \uc88b\uc2b5\ub2c8\ub2e4. \ucd5c\uadfc \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc740 \uc885\uc591 \uc131\uc7a5\uacfc \uc885\uc591 \uc138\ud3ec\uc758 \uc0dd\ubb3c\ud559\uc801 \ud589\ub3d9\uc5d0 \ud2b9\uc815 \uc5b5\uc81c \ud6a8\uacfc\uac00 \uc788\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B55\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc608 \uc678, 2020<\/a>). \ubcf8 \uc5f0\uad6c \uacb0\uacfc, \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc740 \uc720\ubc29\uc554 \uc885\uc591 \ubaa8\ub378\uc5d0\uc11c \ub3c5\uc18c\ub8e8\ube44\uc2e0\uc73c\ub85c \uc778\ud55c \uc2ec\ubd80\uc804\uc744 \uc608\ubc29\ud558\uace0 \uc190\uc0c1\ub41c \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\ub97c \uc81c\uac70\ud574 \uc5fc\uc99d\uc778\uc790 \ubc0f \uba74\uc5ed\uc5b5\uc81c\uc131 \ub300\uc2dd\uc138\ud3ec \uce68\uc724 \uc218\uc900\uc744 \uac10\uc18c\uc2dc\ucf1c \ub3c5\uc18c\ub8e8\ube44\uc2e0\uc758 \ud56d\uc885\uc591 \ud6a8\uacfc\uc640 \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub97c \ubc1c\ud718\ud560 \uc218 \uc788\uc74c\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\ub2e4. \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc740 \uc554\uc5d0 \uc774\uc911 \uce58\ub8cc \uc774\uc810\uc744 \uc81c\uacf5\ud558\uace0 \uc548\ud2b8\ub77c\uc0ac\uc774\ud074\ub9b0\uc758 \uc2ec\uc7a5 \ub3c5\uc131\uc744 \uc608\ubc29\ud568\uc73c\ub85c\uc368 \uc885\uc591 \uc131\uc7a5\uc744 \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc740 \uc548\ud2b8\ub77c\uc0ac\uc774\ud074\ub9b0\uc73c\ub85c \uc720\ubc1c\ub41c \uc2ec\uc7a5 \ub3c5\uc131\uc744 \uc608\ubc29\ud558\uace0 \uc548\ud2b8\ub77c\uc0ac\uc774\ud074\ub9b0\uc5d0 \ub300\ud574 \uc2dc\ub108\uc9c0\uc801\uc778 \ud56d\uc885\uc591 \ud6a8\uacfc\ub97c \ubc1c\ud718\ud558\uc5ec \uc6b0\uc218\ud55c \uc784\uc0c1 \uc801\uc6a9 \uac00\uce58\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"ack-a.m.a\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\uc774 \ud398\uc774\uc9c0\uc758 \ub2e4\ub978 \uc139\uc158\uc73c\ub85c \uc774\ub3d9\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc774\ub3d9 :<\/a><\/div>\n<h2 id=\"ack-a.m.atitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\uac10\uc0ac\uc758 \ub9d0<\/h2>\n<div class=\"sec\">\n<p>\uc800\uc790\ub294 \uc6d0\ubcf8 \ucd08\uc548 \uc900\ube44 \ubc0f \ub370\uc774\ud130 \ud050\ub808\uc774\uc158\uc5d0 \ub300\ud574 \uc911\uad6d \uce6d\ub2e4\uc624\ub300\ud559\uad50 \ubd80\uc18d\ubcd1\uc6d0 \uc554\uc5f0\uad6c\uc18c W-SS\uc5d0 \uac10\uc0ac\ub4dc\ub9bd\ub2c8\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<div id=\"s5\" class=\"tsec bk-sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\uc774 \ud398\uc774\uc9c0\uc758 \ub2e4\ub978 \uc139\uc158\uc73c\ub85c \uc774\ub3d9\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc774\ub3d9 :<\/a><\/div>\n<h2 id=\"s5title\" class=\"head no_bottom_margin ui-helper-clearfix\">\ub370\uc774\ud130 \uac00\uc6a9\uc131 \uc9c4\uc220<\/h2>\n<p class=\"p p-first-last\">\uc5f0\uad6c\uc5d0 \uc81c\uc2dc\ub41c \uc6d0\ub798 \uae30\uc5ec\ub294 \uae30\uc0ac\uc5d0 \ud3ec\ud568\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4.<a class=\"sec\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#s11\">\ubcf4\ucda9 \uc790\ub8cc<\/a>; \ucd94\uac00 \ubb38\uc758\uc0ac\ud56d\uc740 \ud574\ub2f9 \uc800\uc790\uc5d0\uac8c \ubb38\uc758\ud558\uc2dc\uae30 \ubc14\ub78d\ub2c8\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"s6\" class=\"tsec bk-sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\uc774 \ud398\uc774\uc9c0\uc758 \ub2e4\ub978 \uc139\uc158\uc73c\ub85c \uc774\ub3d9\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc774\ub3d9 :<\/a><\/div>\n<h2 id=\"s6title\" class=\"head no_bottom_margin ui-helper-clearfix\">\uc724\ub9ac\uc131\uba85\uc11c<\/h2>\n<p class=\"p p-first-last\">\uc778\uac04 \ucc38\uac00\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \uc5f0\uad6c\ub294 \uce6d\ub2e4\uc624\ub300\ud559\uad50 \ubd80\uc18d\ubcd1\uc6d0 \uc724\ub9ac\uc704\uc6d0\ud68c\uc758 \uac80\ud1a0 \ubc0f \uc2b9\uc778\uc744 \ubc1b\uc558\uc2b5\ub2c8\ub2e4. \ud658\uc790\/\ucc38\uac00\uc790\ub294 \ubcf8 \uc5f0\uad6c\uc5d0 \ucc38\uc5ec\ud558\uae30 \uc704\ud574 \uc11c\uba74 \ub3d9\uc758\uc11c\ub97c \uc81c\uacf5\ud588\uc2b5\ub2c8\ub2e4. \ub3d9\ubb3c \uc5f0\uad6c\ub294 \uce6d\ub2e4\uc624\ub300\ud559\uad50 \uc758\uacfc\ub300\ud559 \uc724\ub9ac\uc704\uc6d0\ud68c\uc758 \uac80\ud1a0\uc640 \uc2b9\uc778\uc744 \ubc1b\uc558\uc2b5\ub2c8\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"s7\" class=\"tsec bk-sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\uc774 \ud398\uc774\uc9c0\uc758 \ub2e4\ub978 \uc139\uc158\uc73c\ub85c \uc774\ub3d9\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc774\ub3d9 :<\/a><\/div>\n<h2 id=\"s7title\" class=\"head no_bottom_margin ui-helper-clearfix\">\uc800\uc790 \uae30\uc5ec<\/h2>\n<p class=\"p p-first-last\">M-JL\uacfc W-SS\ub294 \ubaa8\ub4e0 \uc2e4\ud5d8\uc744 \uc218\ud589\ud558\uace0 \ub370\uc774\ud130\ub97c \ubd84\uc11d\ud558\uace0 \uc6d0\ubcf8 \ucd08\uc548\uc744 \uc791\uc131\ud588\uc2b5\ub2c8\ub2e4. Y-KZ\ub294 \ub370\uc774\ud130\ub97c \ubd84\uc11d\ud558\uace0 \uc6d0\ubcf8 \ucd08\uc548\uc744 \uc791\uc131\ud588\uc2b5\ub2c8\ub2e4. YY\ub294 \ub370\uc774\ud130\ub97c \ubd84\uc11d\ud588\uc2b5\ub2c8\ub2e4. QL\uc740 \ub3d9\ubb3c\uc758 \ub370\uc774\ud130\ub97c \ubd84\uc11d\ud558\uace0 \ud574\uc11d\ud588\uc2b5\ub2c8\ub2e4. Y-ZG\ub294 \ub3d9\ubb3c \uc2e4\ud5d8\uc744 \uc6b4\uc601\ud588\uc2b5\ub2c8\ub2e4. TY\ub294 \ub3d9\ubb3c \uc2e4\ud5d8\uc744 \uc6b4\uc601\ud588\uc2b5\ub2c8\ub2e4. D-MX -\uc6d0\uace0\ub97c \uac80\ud1a0\ud558\uace0 \ud3b8\uc9d1\ud588\uc2b5\ub2c8\ub2e4. \ubaa8\ub4e0 \uc800\uc790\ub294 \ucd5c\uc885 \uc6d0\uace0\ub97c \uc77d\uace0 \uc2b9\uc778\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"s8\" class=\"tsec bk-sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\uc774 \ud398\uc774\uc9c0\uc758 \ub2e4\ub978 \uc139\uc158\uc73c\ub85c \uc774\ub3d9\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc774\ub3d9 :<\/a><\/div>\n<h2 id=\"s8title\" class=\"head no_bottom_margin ui-helper-clearfix\">\uc790\uae08 \uc870\ub2ec<\/h2>\n<p class=\"p p-first-last\">\ubcf8 \uc5f0\uad6c\ub294 \uce6d\ub2e4\uc624 \uc554 \uc5f0\uad6c\uc18c \uc790\uae08 \uc9c0\uc6d0 \uae30\uad00\uacfc \uce6d\ub2e4\uc624 \ubc15\uc0ac\ud6c4 \uc751\uc6a9 \uc5f0\uad6c \ud504\ub85c\uc81d\ud2b8(No. RZ2100005362)\ub85c\ubd80\ud130 \ud2b9\uc815 \ubcf4\uc870\uae08\uc744 \ubc1b\uc558\uc2b5\ub2c8\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"s9\" class=\"tsec bk-sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\uc774 \ud398\uc774\uc9c0\uc758 \ub2e4\ub978 \uc139\uc158\uc73c\ub85c \uc774\ub3d9\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc774\ub3d9 :<\/a><\/div>\n<h2 id=\"s9title\" class=\"head no_bottom_margin ui-helper-clearfix\">\uc774\ud574 \uc0c1\ucda9<\/h2>\n<p class=\"p p-first-last\">\uc800\uc790\ub294 \uc7a0\uc7ac\uc801\uc778 \uc774\ud574 \uc0c1\ucda9\uc73c\ub85c \ud574\uc11d\ub420 \uc218 \uc788\ub294 \uc0c1\uc5c5\uc801 \ub610\ub294 \uc7ac\uc815\uc801 \uad00\uacc4 \uc5c6\uc774 \uc5f0\uad6c\uac00 \uc218\ud589\ub418\uc5c8\uc74c\uc744 \uc120\uc5b8\ud569\ub2c8\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"s10\" class=\"tsec bk-sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\uc774 \ud398\uc774\uc9c0\uc758 \ub2e4\ub978 \uc139\uc158\uc73c\ub85c \uc774\ub3d9\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc774\ub3d9 :<\/a><\/div>\n<h2 id=\"s10title\" class=\"head no_bottom_margin ui-helper-clearfix\">\ucd9c\ud310\uc0ac \uba54\ubaa8<\/h2>\n<p class=\"p p-first-last\">\uc774 \uae30\uc0ac\uc5d0 \ud45c\ud604\ub41c \ubaa8\ub4e0 \uc8fc\uc7a5\uc740 \uc804\uc801\uc73c\ub85c \uc800\uc790\uc758 \uc8fc\uc7a5\uc774\uba70 \uc18c\uc18d \uae30\uad00\uc774\ub098 \ucd9c\ud310\uc0ac, \ud3b8\uc9d1\uc790 \ubc0f \ub9ac\ubdf0\uc5b4\uc758 \uc8fc\uc7a5\uc744 \ubc18\ub4dc\uc2dc \ub300\ud45c\ud558\ub294 \uac83\uc740 \uc544\ub2d9\ub2c8\ub2e4. \uc774 \uae30\uc0ac\uc5d0\uc11c \ud3c9\uac00\ud560 \uc218 \uc788\ub294 \ubaa8\ub4e0 \uc81c\ud488\uc774\ub098 \uc81c\uc870\uc5c5\uccb4\uac00 \uc8fc\uc7a5\ud560 \uc218 \uc788\ub294 \uc8fc\uc7a5\uc740 \uac8c\uc2dc\uc790\uac00 \ubcf4\uc99d\ud558\uac70\ub098 \ubcf4\uc99d\ud558\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"s11\" class=\"tsec bk-sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\uc774 \ud398\uc774\uc9c0\uc758 \ub2e4\ub978 \uc139\uc158\uc73c\ub85c \uc774\ub3d9\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc774\ub3d9 :<\/a><\/div>\n<h2 id=\"s11title\" class=\"head no_bottom_margin ui-helper-clearfix\">\ubcf4\ucda9\uc790\ub8cc<\/h2>\n<p class=\"p p-first\">\uc774 \uae30\uc0ac\uc758 \ubcf4\ucda9 \uc790\ub8cc\ub294 \ub2e4\uc74c \uc628\ub77c\uc778 \uc0ac\uc774\ud2b8\uc5d0\uc11c \ucc3e\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4.\u00a0<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.930835\/full#supplementary-material\" target=\"_blank\" rel=\"noopener\" data-ga-action=\"click_feat_suppl\">https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.930835\/full#supplementary-material<\/a><\/p>\n<div id=\"SM1\" class=\"sec suppmat\">\n<div id=\"media-a.m.h.c.a\" class=\"sup-box half_rhythm\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/bin\/Table1.DOCX\" data-ga-action=\"click_feat_suppl\">\ucd94\uac00 \ub370\uc774\ud130 \ud30c\uc77c\uc744 \ubcf4\ub824\uba74 \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694.<\/a><sup>(2.5M, DOCX)<\/sup><\/div>\n<div><\/div>\n<\/div>\n<\/div>\n<div id=\"ref-list-a.m.i\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\uc774 \ud398\uc774\uc9c0\uc758 \ub2e4\ub978 \uc139\uc158\uc73c\ub85c \uc774\ub3d9\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\uc774\ub3d9 :<\/a><\/div>\n<h2 id=\"ref-list-a.m.ititle\" class=\"head no_bottom_margin ui-helper-clearfix\">\ucc38\uace0\uc790\ub8cc<\/h2>\n<p>&nbsp;<\/p>\n<div id=\"reference-list\" class=\"ref-list-sec sec\">\n<ul class=\"back-ref-list\">\n<li id=\"B1\"><span class=\"mixed-citation\">Alexandre J., Cautela J., Ederhy S., Damaj GL, Salem JE, Barlesi F. \ub4f1 (2020).\u00a0<span class=\"ref-title\">\uc554 \uce58\ub8cc\uc640 \uad00\ub828\ub41c \uc2ec\ud608\uad00 \ub3c5\uc131: \ubbf8\uad6d \ubc0f \uc720\ub7fd\uc758 \uc2ec\uc7a5-\uc885\uc591\ud559 \uc9c0\uce68\uc5d0 \ub300\ud55c \uc2e4\uc6a9\uc801\uc778 \uc811\uadfc \ubc29\uc2dd<\/span>.\u00a0<span class=\"ref-journal\">J.Am. \uc2ec\uc7a5\ud611\ud68c<\/span>\u00a0<span class=\"ref-vol\">9<\/span>\u00a0(<span class=\"ref-iss\">18<\/span>), e018403. 10.1161\/JAHA.120.018403\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7727003\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32893704\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1161%2FJAHA.120.018403\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.+Am.+Heart+Assoc.&amp;title=Cardiovascular+toxicity+related+to+cancer+treatment:+A+pragmatic+approach+to+the+American+and+European+cardio-oncology+guidelines&amp;author=J.+Alexandre&amp;author=J.+Cautela&amp;author=S.+Ederhy&amp;author=G.+L.+Damaj&amp;author=J.+E.+Salem&amp;volume=9&amp;issue=18&amp;publication_year=2020&amp;pages=e018403&amp;pmid=32893704&amp;doi=10.1161\/JAHA.120.018403&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B2\"><span class=\"mixed-citation\">\ubc84\uac70 M., \uadf8\ub808\uc774 JA, \ub85c\uc2a4 BL(2009).\u00a0<span class=\"ref-title\">\uc138\ub85c\ud1a0\ub2cc\uc758 \ud655\uc7a5\ub41c \uc0dd\ubb3c\ud559<\/span>.\u00a0<span class=\"ref-journal\">\uc544\ub204. \uba54\ub514\ube0c \ubaa9\uc0ac.<\/span>\u00a0<span class=\"ref-vol\">60<\/span>, 355-366. 10.1146\/annurev.med.60.042307.110802\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5864293\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19630576\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1146%2Fannurev.med.60.042307.110802\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Annu.+Rev.+Med.&amp;title=The+expanded+biology+of+serotonin&amp;author=M.+Berger&amp;author=J.+A.+Gray&amp;author=B.+L.+Roth&amp;volume=60&amp;publication_year=2009&amp;pages=355-366&amp;pmid=19630576&amp;doi=10.1146\/annurev.med.60.042307.110802&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B3\"><span class=\"mixed-citation\">Bertero E., Maack C. (2018).\u00a0<span class=\"ref-title\">\uc2ec\ubd80\uc804\uc758 \ub300\uc0ac \ub9ac\ubaa8\ub378\ub9c1<\/span>.\u00a0<span class=\"ref-journal\">Nat. Cardiol \ubaa9\uc0ac.<\/span>\u00a0<span class=\"ref-vol\">15<\/span>\u00a0(<span class=\"ref-iss\">8<\/span>), 457-470. 10.1038\/s41569-018-0044-6 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29915254\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1038%2Fs41569-018-0044-6\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Nat.+Rev.+Cardiol.&amp;title=Metabolic+remodelling+in+heart+failure&amp;author=E.+Bertero&amp;author=C.+Maack&amp;volume=15&amp;issue=8&amp;publication_year=2018&amp;pages=457-470&amp;pmid=29915254&amp;doi=10.1038\/s41569-018-0044-6&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B4\"><span class=\"mixed-citation\">Carmean CM, Yokoi N., Takahashi H., Oduori OS, Kang C., Kanagawa A., \uc678. (2019).\u00a0<span class=\"ref-title\">\ube44\uc18c\ub294 \ucdcc\uc7a5 \ubca0\ud0c0 \uc138\ud3ec\uc758 \uae00\ub8e8\ucfe0\ub85c\ub2c8\ub4dc\ud654\ub97c \ud1b5\ud574 \uc138\ub85c\ud1a0\ub2cc \ub300\uc0ac\ub97c \ubcc0\ud615\ud569\ub2c8\ub2e4.<\/span>.\u00a0<span class=\"ref-journal\">\uc624\uc804. J. Physiol. \ub0b4\ubd84\ube44\ub180. \uba54\ud0c0\ud0ed.<\/span>\u00a0<span class=\"ref-vol\">316<\/span>\u00a0(<span class=\"ref-iss\">3<\/span>), E464\u2013E74. 10.1152\/ajpendo.00302.2018\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6459295\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30562058\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1152%2Fajpendo.00302.2018\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Am.+J.+Physiol.+Endocrinol.+Metab.&amp;title=Arsenic+modifies+serotonin+metabolism+through+glucuronidation+in+pancreatic+beta-cells&amp;author=C.+M.+Carmean&amp;author=N.+Yokoi&amp;author=H.+Takahashi&amp;author=O.+S.+Oduori&amp;author=C.+Kang&amp;volume=316&amp;issue=3&amp;publication_year=2019&amp;pages=E464-E74&amp;pmid=30562058&amp;doi=10.1152\/ajpendo.00302.2018&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B5\"><span class=\"mixed-citation\">Chang WT, Lin YW, Ho CH, Chen ZC, Liu PY, Shih JY(2021).\u00a0<span class=\"ref-title\">Dapagliflozin\uc740 ER \uc2a4\ud2b8\ub808\uc2a4\ub97c \uc5b5\uc81c\ud558\uace0 \uc720\ubc29\uc554 \ud658\uc790\uc758 \ub3c5\uc18c\ub8e8\ube44\uc2e0 \uc720\ubc1c \uc2ec\uc7a5 \ub3c5\uc131\uc744 \ubcf4\ud638\ud569\ub2c8\ub2e4<\/span>.\u00a0<span class=\"ref-journal\">\uc544\uce58. \ub3c5\uc131.<\/span>\u00a0<span class=\"ref-vol\">95<\/span>\u00a0(<span class=\"ref-iss\">2<\/span>), 659-671. 10.1007\/s00204-020-02951-8 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33211168\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1007%2Fs00204-020-02951-8\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Arch.+Toxicol.&amp;title=Dapagliflozin+suppresses+ER+stress+and+protects+doxorubicin-induced+cardiotoxicity+in+breast+cancer+patients&amp;author=W.+T.+Chang&amp;author=Y.+W.+Lin&amp;author=C.+H.+Ho&amp;author=Z.+C.+Chen&amp;author=P.+Y.+Liu&amp;volume=95&amp;issue=2&amp;publication_year=2021&amp;pages=659-671&amp;pmid=33211168&amp;doi=10.1007\/s00204-020-02951-8&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B6\"><span class=\"mixed-citation\">Chen Y., Song Y., Du W., Gong L., Chang H., Zou Z. (2019).\u00a0<span class=\"ref-title\">\uc885\uc591 \uad00\ub828 \ub300\uc2dd\uc138\ud3ec: \uace0\ud615 \uc885\uc591 \uc9c4\ud589\uc758 \uacf5\ubc94\uc790<\/span>.\u00a0<span class=\"ref-journal\">J. Biomed. \uacfc\ud559.<\/span>\u00a0<span class=\"ref-vol\">26<\/span>\u00a0(<span class=\"ref-iss\">1<\/span>), 78.10.1186\/s12929-019-0568-z\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6800990\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31629410\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1186%2Fs12929-019-0568-z\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.+Biomed.+Sci.&amp;title=Tumor-associated+macrophages:+An+accomplice+in+solid+tumor+progression&amp;author=Y.+Chen&amp;author=Y.+Song&amp;author=W.+Du&amp;author=L.+Gong&amp;author=H.+Chang&amp;volume=26&amp;issue=1&amp;publication_year=2019&amp;pages=78&amp;pmid=31629410&amp;doi=10.1186\/s12929-019-0568-z&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B7\"><span class=\"mixed-citation\">Dewanjee S., Vallamkondu J., Kalra RS, John A., Reddy PH, Kandimalla R. (2021).\u00a0<span class=\"ref-title\">\ub2f9\ub1e8\ubcd1\uc131 \uc2ec\uc7a5\uc758 \uc790\uac00\ud3ec\uc2dd: \ub2f9\ub1e8\ubcd1\uc131 \uc2ec\uadfc\ubcd1\uc99d\uc758 \uc7a0\uc7ac\uc801\uc778 \uc57d\ubb3c\uce58\ub8cc \ubaa9\ud45c<\/span>.\u00a0<span class=\"ref-journal\">\ub178\ud654 \uc785\uc220. \uc2e0\ubd80\ub2d8.<\/span>\u00a0<span class=\"ref-vol\">68<\/span>, 101338.10.1016\/j.arr.2021.101338 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33838320\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1016%2Fj.arr.2021.101338\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Ageing+Res.+Rev.&amp;title=Autophagy+in+the+diabetic+heart:+A+potential+pharmacotherapeutic+target+in+diabetic+cardiomyopathy&amp;author=S.+Dewanjee&amp;author=J.+Vallamkondu&amp;author=R.+S.+Kalra&amp;author=A.+John&amp;author=P.+H.+Reddy&amp;volume=68&amp;publication_year=2021&amp;pages=101338&amp;pmid=33838320&amp;doi=10.1016\/j.arr.2021.101338&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B8\"><span class=\"mixed-citation\">\ub3c8 GW, 2\ucc28(2016).\u00a0<span class=\"ref-title\">\uc2ec\uc7a5\uc758 \ud30c\ud0a8 \uc758\uc874\uc131 \ubbf8\ud1a0\ud30c\uc9c0<\/span>.\u00a0<span class=\"ref-journal\">J.Mol. \uc140. \uce74\ub514\uc62c.<\/span>\u00a0<span class=\"ref-vol\">95<\/span>, 42\u201349. 10.1016\/j.yjmcc.2015.11.023\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4876055\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26611886\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1016%2Fj.yjmcc.2015.11.023\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.+Mol.+Cell.+Cardiol.&amp;title=Parkin-dependent+mitophagy+in+the+heart&amp;author=G.+W.+Dorn&amp;volume=95&amp;publication_year=2016&amp;pages=42-49&amp;pmid=26611886&amp;doi=10.1016\/j.yjmcc.2015.11.023&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B9\"><span class=\"mixed-citation\">Elinav E., Nowarski R., Thaiss CA, Hu B., Jin C., Flavell RA (2013).\u00a0<span class=\"ref-title\">\uc5fc\uc99d \uc720\ubc1c \uc554: \uc885\uc591, \uba74\uc5ed \uc138\ud3ec \ubc0f \ubbf8\uc0dd\ubb3c \uac04\uc758 \ub204\ud654<\/span>.\u00a0<span class=\"ref-journal\">Nat. \uc554 \ubaa9\uc0ac<\/span>\u00a0<span class=\"ref-vol\">13<\/span>\u00a0(<span class=\"ref-iss\">11<\/span>), 759-771. 10.1038\/nrc3611 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24154716\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1038%2Fnrc3611\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Nat.+Rev.+Cancer&amp;title=Inflammation-induced+cancer:+Crosstalk+between+tumours,+immune+cells+and+microorganisms&amp;author=E.+Elinav&amp;author=R.+Nowarski&amp;author=C.+A.+Thaiss&amp;author=B.+Hu&amp;author=C.+Jin&amp;volume=13&amp;issue=11&amp;publication_year=2013&amp;pages=759-771&amp;pmid=24154716&amp;doi=10.1038\/nrc3611&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B10\"><span class=\"mixed-citation\">Gao J., Chen G., He H., Liu C., Xiong X., Li J., \uc678. (2017).\u00a0<span class=\"ref-title\">\uc2ec\ud608\uad00 \uc9c8\ud658\uc5d0 \ub300\ud55c \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc758 \uce58\ub8cc \ud6a8\uacfc: \uac80\ud1a0<\/span>.\u00a0<span class=\"ref-journal\">\uc55e\ucabd. Pharmacol.<\/span>\u00a0<span class=\"ref-vol\">8<\/span>, 289.10.3389\/fphar.2017.00289\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28588491\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.3389%2Ffphar.2017.00289\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Front.+Pharmacol.&amp;title=Therapeutic+effects+of+breviscapine+in+cardiovascular+diseases:+A+review&amp;author=J.+Gao&amp;author=G.+Chen&amp;author=H.+He&amp;author=C.+Liu&amp;author=X.+Xiong&amp;volume=8&amp;publication_year=2017&amp;pages=289&amp;pmid=28588491&amp;doi=10.3389\/fphar.2017.00289&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B11\"><span class=\"mixed-citation\">\uadf8\ub808\uc774 MW(2012).\u00a0<span class=\"ref-title\">\ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc9c4\ud654<\/span>.\u00a0<span class=\"ref-journal\">\ucf5c\ub4dc \uc2a4\ud504\ub9c1 \ud558\ube0c. \uad00\uc810. Biol.<\/span>\u00a0<span class=\"ref-vol\">4<\/span>\u00a0(<span class=\"ref-iss\">9<\/span>), a011403. 10.1101\/cshperspect.a011403\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3428767\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22952398\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1101%2Fcshperspect.a011403\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Cold+Spring+Harb.+Perspect.+Biol.&amp;title=Mitochondrial+evolution&amp;author=M.+W.+Gray&amp;volume=4&amp;issue=9&amp;publication_year=2012&amp;pages=a011403&amp;pmid=22952398&amp;doi=10.1101\/cshperspect.a011403&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B12\"><span class=\"mixed-citation\">Guo R., Wu K., Chen J., Mo L., Hua X., Zheng D., \uc678. (2013).\u00a0<span class=\"ref-title\">\uc678\uc778\uc131 \ud669\ud654\uc218\uc18c\ub294 H9c2 \uc2ec\uc7a5 \uc138\ud3ec\uc5d0\uc11c p38MAPK\/NF\u03baB \uacbd\ub85c\ub97c \uc5b5\uc81c\ud558\uc5ec \ub3c5\uc18c\ub8e8\ube44\uc2e0 \uc720\ubc1c \uc5fc\uc99d \ubc0f \uc138\ud3ec \ub3c5\uc131\uc73c\ub85c\ubd80\ud130 \ubcf4\ud638\ud569\ub2c8\ub2e4.<\/span>.\u00a0<span class=\"ref-journal\">\uc140. \ubb3c\ub9ac. \uc0dd\ud654\ud559.<\/span>\u00a0<span class=\"ref-vol\">32<\/span>\u00a0(<span class=\"ref-iss\">6<\/span>), 1668-1680. 10.1159\/000356602 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24356372\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1159%2F000356602\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Cell.+Physiol.+biochem.&amp;title=Exogenous+hydrogen+sulfide+protects+against+doxorubicin-induced+inflammation+and+cytotoxicity+by+inhibiting+p38MAPK\/NF%CE%BAB+pathway+in+H9c2+cardiac+cells&amp;author=R.+Guo&amp;author=K.+Wu&amp;author=J.+Chen&amp;author=L.+Mo&amp;author=X.+Hua&amp;volume=32&amp;issue=6&amp;publication_year=2013&amp;pages=1668-1680&amp;pmid=24356372&amp;doi=10.1159\/000356602&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B13\"><span class=\"mixed-citation\">Hulst MB, Grocholski T., Neefjes JJC, van Wezel GP, Metsa-Ketela M.(2021).\u00a0<span class=\"ref-title\">\uc548\ud2b8\ub77c\uc0ac\uc774\ud074\ub9b0: \uc0dd\ud569\uc131, \uc5d4\uc9c0\ub2c8\uc5b4\ub9c1 \ubc0f \uc784\uc0c1 \uc801\uc6a9<\/span>.\u00a0<span class=\"ref-journal\">Nat. \ucc0c\ub974\ub2e4. \ub300\ud45c.<\/span>\u00a0<span class=\"ref-vol\">39<\/span>, 814\u2013841. 10.1039\/d1np00059d [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34951423\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1039%2Fd1np00059d\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Nat.+Prod.+Rep.&amp;title=Anthracyclines:+Biosynthesis,+engineering+and+clinical+applications&amp;author=M.+B.+Hulst&amp;author=T.+Grocholski&amp;author=J.+J.+C.+Neefjes&amp;author=G.+P.+van+Wezel&amp;author=M.+Metsa-Ketela&amp;volume=39&amp;publication_year=2021&amp;pages=814-841&amp;doi=10.1039\/d1np00059d&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B14\"><span class=\"mixed-citation\">Iyengar NM, Gucalp A., Dannenberg AJ, Hudis CA(2016).\u00a0<span class=\"ref-title\">\ube44\ub9cc\uacfc \uc554 \uba54\ucee4\ub2c8\uc998: \uc885\uc591 \ubbf8\uc138\ud658\uacbd\uacfc \uc5fc\uc99d<\/span>.\u00a0<span class=\"ref-journal\">J. \ud074\ub9b0. \uc628\ucf5c.<\/span>\u00a0<span class=\"ref-vol\">34<\/span>\u00a0(<span class=\"ref-iss\">35<\/span>), 4270-4276. 10.1200\/JCO.2016.67.4283\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5562428\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27903155\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1200%2FJCO.2016.67.4283\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.+Clin.+Oncol.&amp;title=Obesity+and+cancer+mechanisms:+Tumor+microenvironment+and+inflammation&amp;author=N.+M.+Iyengar&amp;author=A.+Gucalp&amp;author=A.+J.+Dannenberg&amp;author=C.+A.+Hudis&amp;volume=34&amp;issue=35&amp;publication_year=2016&amp;pages=4270-4276&amp;pmid=27903155&amp;doi=10.1200\/JCO.2016.67.4283&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B15\"><span class=\"mixed-citation\">\uce7c\uc57c\ub098\ub77c\ub9cc B. (2020).\u00a0<span class=\"ref-title\">\ub3c5\uc18c\ub8e8\ube44\uc2e0 \uc720\ubc1c \uc2ec\uc7a5 \ub3c5\uc131 \uba54\ucee4\ub2c8\uc998\uc758 \uae30\ubcf8 \uad50\uc721: \uc6b0\ub9ac\uac00 \uc798\ubabb\ub41c \ub098\ubb34\ub97c \uc9d6\uace0 \uc788\uc5c8\uc2b5\ub2c8\uae4c?<\/span>\u00a0<span class=\"ref-journal\">\ub808\ub3c5\uc2a4\ubc14\uc774\uc62c.<\/span>\u00a0<span class=\"ref-vol\">29<\/span>, 101394.10.1016\/j.redox.2019.101394\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6909145\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31790851\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1016%2Fj.redox.2019.101394\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Redox+Biol.&amp;title=Teaching+the+basics+of+the+mechanism+of+doxorubicin-induced+cardiotoxicity:+Have+we+been+barking+up+the+wrong+tree?&amp;author=B.+Kalyanaraman&amp;volume=29&amp;publication_year=2020&amp;pages=101394&amp;pmid=31790851&amp;doi=10.1016\/j.redox.2019.101394&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B16\"><span class=\"mixed-citation\">\uae40 GH, Uriel N., Burkhoff D. (2018).\u00a0<span class=\"ref-title\">\uc2ec\ubd80\uc804\uc758 \uc5ed \ub9ac\ubaa8\ub378\ub9c1 \ubc0f \uc2ec\uadfc \ud68c\ubcf5<\/span>.\u00a0<span class=\"ref-journal\">Nat. Cardiol \ubaa9\uc0ac.<\/span>\u00a0<span class=\"ref-vol\">15<\/span>\u00a0(<span class=\"ref-iss\">2<\/span>), 83-96. 10.1038\/nrcardio.2017.139 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28933783\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1038%2Fnrcardio.2017.139\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Nat.+Rev.+Cardiol.&amp;title=Reverse+remodelling+and+myocardial+recovery+in+heart+failure&amp;author=G.+H.+Kim&amp;author=N.+Uriel&amp;author=D.+Burkhoff&amp;volume=15&amp;issue=2&amp;publication_year=2018&amp;pages=83-96&amp;pmid=28933783&amp;doi=10.1038\/nrcardio.2017.139&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B17\"><span class=\"mixed-citation\">Kitakata H., Endo J., Ikura H., Moriyama H., Shirakawa K., Katsumata Y., \uc678. (2022).\u00a0<span class=\"ref-title\">DOX \uc720\ubc1c \uc2ec\uadfc\ubcd1\uc99d\uc758 \uce58\ub8cc \ubaa9\ud45c: \uc138\ud3ec\uc0ac\uba78\uacfc Ferroptosis\uc758 \uc5ed\ud560<\/span>.\u00a0<span class=\"ref-journal\">\uad6d\uc81c J.Mol. \uacfc\ud559.<\/span>\u00a0<span class=\"ref-vol\">23<\/span>\u00a0(<span class=\"ref-iss\">3<\/span>), 1414.10.3390\/ijms23031414\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8835899\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35163335\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.3390%2Fijms23031414\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Int.+J.+Mol.+Sci.&amp;title=Therapeutic+targets+for+DOX-induced+cardiomyopathy:+Role+of+apoptosis+vs.+Ferroptosis&amp;author=H.+Kitakata&amp;author=J.+Endo&amp;author=H.+Ikura&amp;author=H.+Moriyama&amp;author=K.+Shirakawa&amp;volume=23&amp;issue=3&amp;publication_year=2022&amp;pages=1414&amp;pmid=35163335&amp;doi=10.3390\/ijms23031414&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B18\"><span class=\"mixed-citation\">Kolwicz SC, Jr., Purohit S., Tian R. (2013).\u00a0<span class=\"ref-title\">\uc2ec\uc7a5 \ub300\uc0ac \ubc0f \uc2ec\uadfc\uc138\ud3ec\uc758 \uc218\ucd95, \uc131\uc7a5 \ubc0f \uc0dd\uc874\uacfc\uc758 \uc0c1\ud638\uc791\uc6a9<\/span>.\u00a0<span class=\"ref-journal\">\uc21c\ud658 \uacb0\uc758\uc548.<\/span>\u00a0<span class=\"ref-vol\">113<\/span>\u00a0(<span class=\"ref-iss\">5<\/span>), 603-616. 10.1161\/CIRCRESAHA.113.302095\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3845521\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23948585\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1161%2FCIRCRESAHA.113.302095\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Circ.+Res.&amp;title=Cardiac+metabolism+and+its+interactions+with+contraction,+growth,+and+survival+of+cardiomyocytes&amp;author=S.+C.+Kolwicz&amp;author=S.+Purohit&amp;author=R.+Tian&amp;volume=113&amp;issue=5&amp;publication_year=2013&amp;pages=603-616&amp;pmid=23948585&amp;doi=10.1161\/CIRCRESAHA.113.302095&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B19\"><span class=\"mixed-citation\">Kolwicz SC, Jr., Tian R. (2011).\u00a0<span class=\"ref-title\">\ud3ec\ub3c4\ub2f9 \ub300\uc0ac\uc640 \uc2ec\uc7a5 \ube44\ub300<\/span>.\u00a0<span class=\"ref-journal\">\uc2ec\ud608\uad00. \uacb0\uc758\uc548.<\/span>\u00a0<span class=\"ref-vol\">90<\/span>\u00a0(<span class=\"ref-iss\">2<\/span>), 194-201. 10.1093\/cvr\/cvr071\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3078804\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21502371\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1093%2Fcvr%2Fcvr071\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Cardiovasc.+Res.&amp;title=Glucose+metabolism+and+cardiac+hypertrophy&amp;author=S.+C.+Kolwicz&amp;author=R.+Tian&amp;volume=90&amp;issue=2&amp;publication_year=2011&amp;pages=194-201&amp;pmid=21502371&amp;doi=10.1093\/cvr\/cvr071&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B20\"><span class=\"mixed-citation\">\ub9ac\ubc14\uc774\uc2a4 BE, Binkley PF, \uc0e4\ud53c\ub85c CL(2017).\u00a0<span class=\"ref-title\">\uc548\ud2b8\ub77c\uc0ac\uc774\ud074\ub9b0 \uae30\ubc18 \uce58\ub8cc\uc758 \uc2ec\uc7a5 \ub3c5\uc131 \ud6a8\uacfc: \uc99d\uac70\ub294 \ubb34\uc5c7\uc774\uba70 \uc7a0\uc7ac\uc801\uc778 \ud53c\ud574\ub294 \ubb34\uc5c7\uc785\ub2c8\uae4c?<\/span>\u00a0<span class=\"ref-journal\">\ub79c\uc2ef. \uc628\ucf5c.<\/span>\u00a0<span class=\"ref-vol\">18<\/span>\u00a0(<span class=\"ref-iss\">8<\/span>), e445\u2013e456. 10.1016\/S1470-2045(17)30535-1 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28759384\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1016%2FS1470-2045(17)30535-1\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Lancet.+Oncol.&amp;title=Cardiotoxic+effects+of+anthracycline-based+therapy:+What+is+the+evidence+and+what+are+the+potential+harms?&amp;author=B.+E.+Levis&amp;author=P.+F.+Binkley&amp;author=C.+L.+Shapiro&amp;volume=18&amp;issue=8&amp;publication_year=2017&amp;pages=e445-e456&amp;pmid=28759384&amp;doi=10.1016\/S1470-2045(17)30535-1&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B21\"><span class=\"mixed-citation\">Li M., Sala V., De Santis MC, Cimino J., Cappello P., Pianca N., \uc678. (2018).\u00a0<span class=\"ref-title\">\ud3ec\uc2a4\ud3ec\uc774\ub178\uc2dc\ud2f0\ub4dc 3-\ud0a4\ub098\uc81c \uac10\ub9c8 \uc5b5\uc81c\ub294 \uc548\ud2b8\ub77c\uc0ac\uc774\ud074\ub9b0 \uc2ec\uc7a5 \ub3c5\uc131\uc744 \ubc29\uc9c0\ud558\uace0 \uc885\uc591 \uc131\uc7a5\uc744 \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4.<\/span>.\u00a0<span class=\"ref-journal\">\uc21c\ud658<\/span>\u00a0<span class=\"ref-vol\">138<\/span>\u00a0(<span class=\"ref-iss\">7<\/span>), 696-711. 10.1161\/CIRCULATIONAHA.117.030352 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29348263\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1161%2FCIRCULATIONAHA.117.030352\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Circulation&amp;title=Phosphoinositide+3-kinase+gamma+inhibition+protects+from+anthracycline+cardiotoxicity+and+reduces+tumor+growth&amp;author=M.+Li&amp;author=V.+Sala&amp;author=M.+C.+De+Santis&amp;author=J.+Cimino&amp;author=P.+Cappello&amp;volume=138&amp;issue=7&amp;publication_year=2018&amp;pages=696-711&amp;pmid=29348263&amp;doi=10.1161\/CIRCULATIONAHA.117.030352&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B22\"><span class=\"mixed-citation\">Li M., Yuan Y., Sun W., Zhang Y., Lu Q., Zou L., \uc678. (2022).\u00a0<span class=\"ref-title\">\ub300\uc0ac\uccb4\ud559\uc5d0 \uae30\ucd08\ud55c \ub3c5\uc18c\ub8e8\ube44\uc2e0 \uc720\ubc1c \uc2ec\uc7a5\ub3c5\uc131\uc5d0 \ub300\ud55c \ube0c\ub808\ube44\uc2a4\uce74\ud540\uc758 \uae30\uc804<\/span>.\u00a0<span class=\"ref-journal\">\ud131. \ubaa9\ucd08. \uba54\ub4dc.<\/span>\u00a0<span class=\"ref-vol\">53<\/span>\u00a0(<span class=\"ref-iss\">08<\/span>), 2356-2367. 10.7501\/j.issn.0253-2670.2022.08.0 [<a href=\"https:\/\/doi.org\/10.7501%2Fj.issn.0253-2670.2022.08.0\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Chin.+Herb.+Med.&amp;title=Mechanisms+of+breviscapine+against+doxo+rubicin-induced+cardiotoxicity+based+on+metabolomics&amp;author=M.+Li&amp;author=Y.+Yuan&amp;author=W.+Sun&amp;author=Y.+Zhang&amp;author=Q.+Lu&amp;volume=53&amp;issue=08&amp;publication_year=2022&amp;pages=2356-2367&amp;doi=10.7501\/j.issn.0253-2670.2022.08.0&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B23\"><span class=\"mixed-citation\">\ub9ac Z., \uc7a5 H. (2016).\u00a0<span class=\"ref-title\">\uc554 \uc9c4\ud589\uc744 \uc704\ud55c \ud3ec\ub3c4\ub2f9, \uc9c0\ubc29\uc0b0, \uc544\ubbf8\ub178\uc0b0 \ub300\uc0ac \uc7ac\ud504\ub85c\uadf8\ub798\ubc0d<\/span>.\u00a0<span class=\"ref-journal\">\uc140. \ubab0. \uc0dd\uba85 \uacfc\ud559.<\/span>\u00a0<span class=\"ref-vol\">73<\/span>\u00a0(<span class=\"ref-iss\">2<\/span>), 377-392. 10.1007\/s00018-015-2070-4 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26499846\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1007%2Fs00018-015-2070-4\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Cell.+Mol.+Life+Sci.&amp;title=Reprogramming+of+glucose,+fatty+acid+and+amino+acid+metabolism+for+cancer+progression&amp;author=Z.+Li&amp;author=H.+Zhang&amp;volume=73&amp;issue=2&amp;publication_year=2016&amp;pages=377-392&amp;pmid=26499846&amp;doi=10.1007\/s00018-015-2070-4&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B24\"><span class=\"mixed-citation\">Liu H., Wang H., Xiang D., Guo W. (2017).\u00a0<span class=\"ref-title\">\ub3c5\uc18c\ub8e8\ube44\uc2e0 \uc720\ubc1c \uc2ec\uc7a5\ub3c5\uc131\uc744 \uc608\ubc29\ud558\uae30 \uc704\ud55c \uc57d\ud559\uc801 \uc870\uce58<\/span>.\u00a0<span class=\"ref-journal\">\ubbf8\ub2c8 \ubaa9\uc0ac Med. \ud654\ud559.<\/span>\u00a0<span class=\"ref-vol\">17<\/span>\u00a0(<span class=\"ref-iss\">1<\/span>), 44\u201350. 10.2174\/1389557516666160621083659 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27337969\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.2174%2F1389557516666160621083659\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Mini+Rev.+Med.+Chem.&amp;title=Pharmaceutical+measures+to+prevent+doxorubicin-induced+cardiotoxicity&amp;author=H.+Liu&amp;author=H.+Wang&amp;author=D.+Xiang&amp;author=W.+Guo&amp;volume=17&amp;issue=1&amp;publication_year=2017&amp;pages=44-50&amp;pmid=27337969&amp;doi=10.2174\/1389557516666160621083659&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B25\"><span class=\"mixed-citation\">Lopaschuk GD, Ussher JR, Folmes CD, Jaswal JS, Stanley WC(2010).\u00a0<span class=\"ref-title\">\uac74\uac15\uacfc \uc9c8\ubcd1\uc5d0\uc11c\uc758 \uc2ec\uadfc\uc9c0\ubc29\uc0b0 \ub300\uc0ac<\/span>.\u00a0<span class=\"ref-journal\">\ubb3c\ub9ac. \uc2e0\ubd80\ub2d8.<\/span>\u00a0<span class=\"ref-vol\">90<\/span>\u00a0(<span class=\"ref-iss\">1<\/span>), 207-258. 10.1152\/physrev.00015.2009 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20086077\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1152%2Fphysrev.00015.2009\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Physiol.+Rev.&amp;title=Myocardial+fatty+acid+metabolism+in+health+and+disease&amp;author=G.+D.+Lopaschuk&amp;author=J.+R.+Ussher&amp;author=C.+D.+Folmes&amp;author=J.+S.+Jaswal&amp;author=W.+C.+Stanley&amp;volume=90&amp;issue=1&amp;publication_year=2010&amp;pages=207-258&amp;pmid=20086077&amp;doi=10.1152\/physrev.00015.2009&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B26\"><span class=\"mixed-citation\">Lopaschuk GD, Karwi QG, Tian R., Wende AR, Abel ED(2021).\u00a0<span class=\"ref-title\">\uc2ec\ubd80\uc804\uc5d0\uc11c\uc758 \uc2ec\uc7a5 \uc5d0\ub108\uc9c0 \ub300\uc0ac<\/span>.\u00a0<span class=\"ref-journal\">\uc21c\ud658 \uacb0\uc758\uc548.<\/span>\u00a0<span class=\"ref-vol\">128<\/span>\u00a0(<span class=\"ref-iss\">10<\/span>), 1487-1513. 10.1161\/CIRCRESAHA.121.318241\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8136750\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33983836\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1161%2FCIRCRESAHA.121.318241\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Circ.+Res.&amp;title=Cardiac+energy+metabolism+in+heart+failure&amp;author=G.+D.+Lopaschuk&amp;author=Q.+G.+Karwi&amp;author=R.+Tian&amp;author=A.+R.+Wende&amp;author=E.+D.+Abel&amp;volume=128&amp;issue=10&amp;publication_year=2021&amp;pages=1487-1513&amp;pmid=33983836&amp;doi=10.1161\/CIRCRESAHA.121.318241&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B27\"><span class=\"mixed-citation\">McGowan JV, Chung R., Maulik A., Piotrowska I., Walker JM, Yellon DM (2017).\u00a0<span class=\"ref-title\">\uc548\ud2b8\ub77c\uc0ac\uc774\ud074\ub9b0 \ud654\ud559\uc694\ubc95 \ubc0f \uc2ec\uc7a5 \ub3c5\uc131<\/span>.\u00a0<span class=\"ref-journal\">\uc2ec\ud608\uad00. \ub9c8\uc57d \uac70\uae30.<\/span>\u00a0<span class=\"ref-vol\">31<\/span>\u00a0(<span class=\"ref-iss\">1<\/span>), 63-75. 10.1007\/s10557-016-6711-0\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5346598\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28185035\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1007%2Fs10557-016-6711-0\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Cardiovasc.+Drugs+Ther.&amp;title=Anthracycline+chemotherapy+and+cardiotoxicity&amp;author=J.+V.+McGowan&amp;author=R.+Chung&amp;author=A.+Maulik&amp;author=I.+Piotrowska&amp;author=J.+M.+Walker&amp;volume=31&amp;issue=1&amp;publication_year=2017&amp;pages=63-75&amp;pmid=28185035&amp;doi=10.1007\/s10557-016-6711-0&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B28\"><span class=\"mixed-citation\">\uba3c DH, \uba5c\ub7ec AL(2016).\u00a0<span class=\"ref-title\">\uc885\uc591 \ubbf8\uc138\ud658\uacbd\uc758 \uc774\ub3c4: \uc5fc\uc99d, \uc5ed\uc870\uc808 \ubc0f \ub0b4\uc131<\/span>.\u00a0<span class=\"ref-journal\">\ud2b8\ub80c\ub4dc \uba74\uc5ed.<\/span>\u00a0<span class=\"ref-vol\">37<\/span>\u00a0(<span class=\"ref-iss\">3<\/span>), 193-207. 10.1016\/j.it.2016.01.002\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4916957\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26839260\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1016%2Fj.it.2016.01.002\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Trends+Immunol.&amp;title=Ido+in+the+tumor+microenvironment:+Inflammation,+counter-regulation,+and+tolerance&amp;author=D.+H.+Munn&amp;author=A.+L.+Mellor&amp;volume=37&amp;issue=3&amp;publication_year=2016&amp;pages=193-207&amp;pmid=26839260&amp;doi=10.1016\/j.it.2016.01.002&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B29\"><span class=\"mixed-citation\">Murashige D., Zhang C., Neinast M., Edwards JJ, Cowan A., Hyman MC \ub4f1 (2020).\u00a0<span class=\"ref-title\">\uace0\uc7a5\ub09c \uc778\uac04 \uc2ec\uc7a5\uacfc \uace0\uc7a5\ub098\uc9c0 \uc54a\uc740 \uc778\uac04 \uc2ec\uc7a5\uc758 \uc5f0\ub8cc \uc0ac\uc6a9\uc744 \uc885\ud569\uc801\uc73c\ub85c \uc815\ub7c9\ud654<\/span>.\u00a0<span class=\"ref-journal\">\uacfc\ud559<\/span>\u00a0<span class=\"ref-vol\">370<\/span>\u00a0(<span class=\"ref-iss\">6514<\/span>), 364-368. 10.1126\/science.abc8861\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7871704\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33060364\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1126%2Fscience.abc8861\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Science&amp;title=Comprehensive+quantification+of+fuel+use+by+the+failing+and+nonfailing+human+heart&amp;author=D.+Murashige&amp;author=C.+Jang&amp;author=M.+Neinast&amp;author=J.+J.+Edwards&amp;author=A.+Cowan&amp;volume=370&amp;issue=6514&amp;publication_year=2020&amp;pages=364-368&amp;pmid=33060364&amp;doi=10.1126\/science.abc8861&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B30\"><span class=\"mixed-citation\">Nhu NT, Li Q., Liu Y., Xu J., Xiao SY, Lee SD(2021).\u00a0<span class=\"ref-title\">\ub1cc\uc878\uc911 \ud6c4 \ud5c8\ud608-\uc7ac\uad00\ub958 \uc190\uc0c1\uc5d0\uc11c mdivi-1\uc774 \uc2e0\uacbd \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5 \uc7a5\uc560 \ubc0f \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ub9e4\uac1c \uc138\ud3ec \uc0ac\uba78\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5: \uc804\uc784\uc0c1 \uc5f0\uad6c\uc5d0 \ub300\ud55c \uccb4\uacc4\uc801\uc778 \uac80\ud1a0<\/span>.\u00a0<span class=\"ref-journal\">\uc55e\ucabd. \ubab0. \uc2e0\uacbd \uacfc\ud559.<\/span>\u00a0<span class=\"ref-vol\">14<\/span>, 778569.10.3389\/fnmol.2021.778569\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8740201\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35002619\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.3389%2Ffnmol.2021.778569\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Front.+Mol.+Neurosci.&amp;title=Effects+of+mdivi-1+on+neural+mitochondrial+dysfunction+and+mitochondria-mediated+apoptosis+in+ischemia-reperfusion+injury+after+stroke:+A+systematic+review+of+preclinical+studies&amp;author=N.+T.+Nhu&amp;author=Q.+Li&amp;author=Y.+Liu&amp;author=J.+Xu&amp;author=S.+Y.+Xiao&amp;volume=14&amp;publication_year=2021&amp;pages=778569&amp;pmid=35002619&amp;doi=10.3389\/fnmol.2021.778569&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B31\"><span class=\"mixed-citation\">Okaty BW, Commons KG, Dymecki SM(2019).\u00a0<span class=\"ref-title\">5-HT \uc2e0\uacbd \uc2dc\uc2a4\ud15c\uc758 \ub2e4\uc591\uc131 \uc218\uc6a9<\/span>.\u00a0<span class=\"ref-journal\">Nat. Neurosci \ubaa9\uc0ac.<\/span>\u00a0<span class=\"ref-vol\">20<\/span>\u00a0(<span class=\"ref-iss\">7<\/span>), 397-424. 10.1038\/s41583-019-0151-3 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30948838\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1038%2Fs41583-019-0151-3\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Nat.+Rev.+Neurosci.&amp;title=Embracing+diversity+in+the+5-HT+neuronal+system&amp;author=B.+W.+Okaty&amp;author=K.+G.+Commons&amp;author=S.+M.+Dymecki&amp;volume=20&amp;issue=7&amp;publication_year=2019&amp;pages=397-424&amp;pmid=30948838&amp;doi=10.1038\/s41583-019-0151-3&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B32\"><span class=\"mixed-citation\">Pan Y., Yu Y., Wang X., Zhang T. (2020).\u00a0<span class=\"ref-title\">\uc885\uc591 \uba74\uc5ed\uc758 \uc885\uc591 \uad00\ub828 \ub300\uc2dd\uc138\ud3ec<\/span>.\u00a0<span class=\"ref-journal\">\uc55e\ucabd. \uba74\uc5ed.<\/span>\u00a0<span class=\"ref-vol\">11<\/span>, 583084.10.3389\/fimmu.2020.583084\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7751482\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33365025\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.3389%2Ffimmu.2020.583084\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Front.+Immunol.&amp;title=Tumor-associated+macrophages+in+tumor+immunity&amp;author=Y.+Pan&amp;author=Y.+Yu&amp;author=X.+Wang&amp;author=T.+Zhang&amp;volume=11&amp;publication_year=2020&amp;pages=583084&amp;pmid=33365025&amp;doi=10.3389\/fimmu.2020.583084&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B33\"><span class=\"mixed-citation\">\ud480 LP, \ub9e4\ud074\ub77c\uc6b0\ub4dc KF(2021).\u00a0<span class=\"ref-title\">\uc885\uc591 \ud615\uc131 \ubc0f \uc804\uc774\uc758 \ubbf8\ud1a0\ud30c\uc9c0<\/span>.\u00a0<span class=\"ref-journal\">\uc140. \ubab0. \uc0dd\uba85 \uacfc\ud559.<\/span>\u00a0<span class=\"ref-vol\">78<\/span>\u00a0(<span class=\"ref-iss\">8<\/span>), 3817-3851. 10.1007\/s00018-021-03774-1\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8259496\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33580835\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1007%2Fs00018-021-03774-1\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Cell.+Mol.+Life+Sci.&amp;title=Mitophagy+in+tumorigenesis+and+metastasis&amp;author=L.+P.+Poole&amp;author=K.+F.+Macleod&amp;volume=78&amp;issue=8&amp;publication_year=2021&amp;pages=3817-3851&amp;pmid=33580835&amp;doi=10.1007\/s00018-021-03774-1&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B34\"><span class=\"mixed-citation\">Randle PJ, Garland PB, Hales CN, Newsholme EA(1963).\u00a0<span class=\"ref-title\">\ud3ec\ub3c4\ub2f9 \uc9c0\ubc29\uc0b0 \uc21c\ud658. \uc778\uc290\ub9b0 \uac10\uc218\uc131 \ubc0f \ub2f9\ub1e8\ubcd1\uc758 \ub300\uc0ac \uc7a5\uc560\uc5d0\uc11c\uc758 \uc5ed\ud560<\/span>.\u00a0<span class=\"ref-journal\">\ub79c\uc2ef<\/span>\u00a0<span class=\"ref-vol\">1<\/span>\u00a0(<span class=\"ref-iss\">7285<\/span>), 785-789. 10.1016\/s0140-6736(63)91500-9 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/13990765\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1016%2Fs0140-6736(63)91500-9\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Lancet&amp;title=The+glucose+fatty-acid+cycle.+Its+role+in+insulin+sensitivity+and+the+metabolic+disturbances+of+diabetes+mellitus&amp;author=P.+J.+Randle&amp;author=P.+B.+Garland&amp;author=C.+N.+Hales&amp;author=E.+A.+Newsholme&amp;volume=1&amp;issue=7285&amp;publication_year=1963&amp;pages=785-789&amp;pmid=13990765&amp;doi=10.1016\/s0140-6736(63)91500-9&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B35\"><span class=\"mixed-citation\">Sangweni NF, Moremane M., Riedel S., van Vuuren D., Huisamen B., Mabasa L., \uc678. (2020).\u00a0<span class=\"ref-title\">\ub3c5\uc18c\ub8e8\ube44\uc2e0 \uc720\ubc1c \uc2ec\uc7a5 \ub3c5\uc131\uc5d0 \ub300\ud55c \ud53c\ub178\uc148\ube0c\ub9b0\uc758 \uc608\ubc29 \ud6a8\uacfc\u00a0<em>\uc2dc\ud5d8\uad00 \ub0b4\uc5d0\uc11c<\/em>\u00a0H9c2 \uc138\ud3ec \ubaa8\ub378<\/span>.\u00a0<span class=\"ref-journal\">\uc55e\ucabd. Pharmacol.<\/span>\u00a0<span class=\"ref-vol\">11<\/span>, 1172.10.3389\/fphar.2020.01172\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7438920\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32903793\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.3389%2Ffphar.2020.01172\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Front.+Pharmacol.&amp;title=The+prophylactic+effect+of+pinocembrin+against+doxorubicin-induced+cardiotoxicity+in+an+in+vitro+H9c2+cell+model&amp;author=N.+F.+Sangweni&amp;author=M.+Moremane&amp;author=S.+Riedel&amp;author=D.+van+Vuuren&amp;author=B.+Huisamen&amp;volume=11&amp;publication_year=2020&amp;pages=1172&amp;pmid=32903793&amp;doi=10.3389\/fphar.2020.01172&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B36\"><span class=\"mixed-citation\">Sautes-Fridman C., Petitprez F., Calderaro J., Fridman WH (2019).\u00a0<span class=\"ref-title\">\uc554 \uba74\uc5ed\uce58\ub8cc \uc2dc\ub300\uc758 3\ucc28 \ub9bc\ud504\uad6c\uc870<\/span>.\u00a0<span class=\"ref-journal\">Nat. \uc554 \ubaa9\uc0ac<\/span>\u00a0<span class=\"ref-vol\">19<\/span>\u00a0(<span class=\"ref-iss\">6<\/span>), 307-325. 10.1038\/s41568-019-0144-6 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31092904\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1038%2Fs41568-019-0144-6\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Nat.+Rev.+Cancer&amp;title=Tertiary+lymphoid+structures+in+the+era+of+cancer+immunotherapy&amp;author=C.+Sautes-Fridman&amp;author=F.+Petitprez&amp;author=J.+Calderaro&amp;author=W.+H.+Fridman&amp;volume=19&amp;issue=6&amp;publication_year=2019&amp;pages=307-325&amp;pmid=31092904&amp;doi=10.1038\/s41568-019-0144-6&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B37\"><span class=\"mixed-citation\">Sawicki KT, Sala V., Prever L., Hirsch E., Ardehali H., Ghigo A. (2021).\u00a0<span class=\"ref-title\">\uc548\ud2b8\ub77c\uc0ac\uc774\ud074\ub9b0 \uc2ec\uc7a5 \ub3c5\uc131 \uc608\ubc29 \ubc0f \uce58\ub8cc: \uc0c8\ub85c\uc6b4 \ud1b5\ucc30\ub825<\/span>.\u00a0<span class=\"ref-journal\">\uc544\ub204. Pharmacol \ubaa9\uc0ac. \ub3c5\uc131.<\/span>\u00a0<span class=\"ref-vol\">61<\/span>, 309-332. 10.1146\/annurev-pharmtox-030620-104842 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33022184\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1146%2Fannurev-pharmtox-030620-104842\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Annu.+Rev.+Pharmacol.+Toxicol.&amp;title=Preventing+and+treating+anthracycline+cardiotoxicity:+New+insights&amp;author=K.+T.+Sawicki&amp;author=V.+Sala&amp;author=L.+Prever&amp;author=E.+Hirsch&amp;author=H.+Ardehali&amp;volume=61&amp;publication_year=2021&amp;pages=309-332&amp;pmid=33022184&amp;doi=10.1146\/annurev-pharmtox-030620-104842&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B38\"><span class=\"mixed-citation\">Shabalala S., Muller CJF, Louw J., Johnson R. (2017).\u00a0<span class=\"ref-title\">\ud3f4\ub9ac\ud398\ub180, \uc790\uac00\ud3ec\uc2dd \ubc0f \ub3c5\uc18c\ub8e8\ube44\uc2e0 \uc720\ubc1c \uc2ec\uc7a5 \ub3c5\uc131<\/span>.\u00a0<span class=\"ref-journal\">\uc0dd\uba85 \uacfc\ud559.<\/span>\u00a0<span class=\"ref-vol\">180<\/span>, 160~170. 10.1016\/j.lfs.2017.05.003 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28478263\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1016%2Fj.lfs.2017.05.003\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Life+Sci.&amp;title=Polyphenols,+autophagy+and+doxorubicin-induced+cardiotoxicity&amp;author=S.+Shabalala&amp;author=C.+J.+F.+Muller&amp;author=J.+Louw&amp;author=R.+Johnson&amp;volume=180&amp;publication_year=2017&amp;pages=160-170&amp;pmid=28478263&amp;doi=10.1016\/j.lfs.2017.05.003&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B39\"><span class=\"mixed-citation\">\uc0e4\uc624 D., \ud2f0\uc548 R. (2015).\u00a0<span class=\"ref-title\">\uc2ec\uc7a5 \ub300\uc0ac \ubc0f \ube44\ub300\uc5d0\uc11c\uc758 \ud3ec\ub3c4\ub2f9 \uc218\uc1a1\uccb4<\/span>.\u00a0<span class=\"ref-journal\">\ube44\uad50. \ubb3c\ub9ac.<\/span>\u00a0<span class=\"ref-vol\">6<\/span>\u00a0(<span class=\"ref-iss\">1<\/span>), 331-351. 10.1002\/cphy.c150016\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4760112\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26756635\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1002%2Fcphy.c150016\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Compr.+Physiol.&amp;title=Glucose+transporters+in+cardiac+metabolism+and+hypertrophy&amp;author=D.+Shao&amp;author=R.+Tian&amp;volume=6&amp;issue=1&amp;publication_year=2015&amp;pages=331-351&amp;pmid=26756635&amp;doi=10.1002\/cphy.c150016&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B40\"><span class=\"mixed-citation\">\uc194\ub77c\ub85c CR, \uc194\ub77c\ub85c RJ(2020).\u00a0<span class=\"ref-title\">\uc2ec\uc7a5 \uc9c8\ud658\uc5d0 \ub300\ud55c \ud608\uccad \ubc14\uc774\uc624\ub9c8\ucee4\ub85c\uc11c \uace0\uce5c\ud654\uc131 \ud2b8\ub85c\ud3ec\ub2cc \ud56d\uccb4\uc758 \uc0ac\uc6a9\uc5d0 \uc788\uc5b4\uc11c \uc2ec\uc7a5 \uadfc\uc808\uc758 \ubcf5\uc7a1\ud55c \uc0dd\ubb3c\ud559 \ubc0f \ubbf8\uc138 \ud658\uacbd\uc758 \uc758\ubbf8<\/span>.\u00a0<span class=\"ref-journal\">J.Mol. \uc140. \uce74\ub514\uc62c.<\/span>\u00a0<span class=\"ref-vol\">143<\/span>, 145\u2013158. 10.1016\/j.yjmcc.2020.05.010\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7235571\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32442660\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1016%2Fj.yjmcc.2020.05.010\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.+Mol.+Cell.+Cardiol.&amp;title=Implications+of+the+complex+biology+and+micro-environment+of+cardiac+sarcomeres+in+the+use+of+high+affinity+troponin+antibodies+as+serum+biomarkers+for+cardiac+disorders&amp;author=C.+R.+Solaro&amp;author=R.+J.+Solaro&amp;volume=143&amp;publication_year=2020&amp;pages=145-158&amp;pmid=32442660&amp;doi=10.1016\/j.yjmcc.2020.05.010&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B41\"><span class=\"mixed-citation\">Sun Y., Ping Y., Miao S., Li Z., Pan C., Shen S., \uc678. (2022).\u00a0<span class=\"ref-title\">\uc131\uc778 \uc720\ubc29\uc554 \ud658\uc790\uc758 \ub9ac\ud3ec\uc880 \ub3c5\uc18c\ub8e8\ube44\uc2e0 \uc720\ubc1c \uc2ec\uc7a5\ub3c5\uc131\uc5d0 \ub300\ud55c \ub2e4\ubcc0\ub7c9 \uc784\uc0c1 \uc608\uce21 \ubaa8\ub378 \uac1c\ubc1c: \ud6c4\ud5a5\uc801 \ub2e4\uae30\uad00 \uc5f0\uad6c<\/span>.\u00a0<span class=\"ref-journal\">\uc564. \ubc88\uc5ed. \uba54\ub4dc.<\/span>\u00a0<span class=\"ref-vol\">10<\/span>\u00a0(<span class=\"ref-iss\">10<\/span>), 605. 10.21037\/atm-22-1935\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9201141\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35722371\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.21037%2Fatm-22-1935\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Ann.+Transl.+Med.&amp;title=Development+of+a+multivariable+clinical+prediction+model+for+liposomal+doxorubicin-induced+cardiotoxicity+in+adult+breast+cancer+patients:+A+retrospective+multicenter+study&amp;author=Y.+Sun&amp;author=Y.+Ping&amp;author=S.+Miao&amp;author=Z.+Li&amp;author=C.+Pan&amp;volume=10&amp;issue=10&amp;publication_year=2022&amp;pages=605&amp;pmid=35722371&amp;doi=10.21037\/atm-22-1935&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B42\"><span class=\"mixed-citation\">Syahputra RA, Harahap U., Dalimunthe A., Nasution MP, Satria D. (2022).\u00a0<span class=\"ref-title\">\ub3c5\uc18c\ub8e8\ube44\uc2e0 \uc720\ubc1c \uc2ec\uc7a5 \ub3c5\uc131\uc5d0 \ub300\ud55c \uc2ec\uc7a5 \ubcf4\ud638 \uc804\ub7b5\uc73c\ub85c\uc11c\uc758 \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc\uc758 \uc5ed\ud560: \uac80\ud1a0<\/span>.\u00a0<span class=\"ref-journal\">\ubd84\uc790<\/span>\u00a0<span class=\"ref-vol\">27<\/span>\u00a0(<span class=\"ref-iss\">4<\/span>), 1320. 10.3390\/molecules27041320\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8878416\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35209107\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.3390%2Fmolecules27041320\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Molecules&amp;title=The+role+of+flavonoids+as+a+cardioprotective+strategy+against+doxorubicin-induced+cardiotoxicity:+A+review&amp;author=R.+A.+Syahputra&amp;author=U.+Harahap&amp;author=A.+Dalimunthe&amp;author=M.+P.+Nasution&amp;author=D.+Satria&amp;volume=27&amp;issue=4&amp;publication_year=2022&amp;pages=1320&amp;pmid=35209107&amp;doi=10.3390\/molecules27041320&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B43\"><span class=\"mixed-citation\">\ub2e4\ucf00\ubb34\ub77c G., \ud6c4\uc9c0\uc640\ub77c H. (2007).\u00a0<span class=\"ref-title\">\ub3c5\uc18c\ub8e8\ube44\uc2e0 \uc720\ubc1c \uc2ec\uadfc\ubcd1\uc99d\uc758 \uc2ec\uc7a5\ub3c5\uc131 \uae30\uc804\ubd80\ud130 \uad00\ub9ac\uae4c\uc9c0<\/span>.\u00a0<span class=\"ref-journal\">\uc74c\uc2dd\ubb3c. \uc2ec\ud608\uad00. \ub514\uc2a4.<\/span>\u00a0<span class=\"ref-vol\">49<\/span>\u00a0(<span class=\"ref-iss\">5<\/span>), 330-352. 10.1016\/j.pcad.2006.10.002 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17329180\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1016%2Fj.pcad.2006.10.002\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Prog.+Cardiovasc.+Dis.&amp;title=Doxorubicin-induced+cardiomyopathy+from+the+cardiotoxic+mechanisms+to+management&amp;author=G.+Takemura&amp;author=H.+Fujiwara&amp;volume=49&amp;issue=5&amp;publication_year=2007&amp;pages=330-352&amp;pmid=17329180&amp;doi=10.1016\/j.pcad.2006.10.002&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B44\"><span class=\"mixed-citation\">Timm KN, Miller JJ, Henry JA, Tyler DJ(2018).\u00a0<span class=\"ref-title\">\uacfc\ubd84\uadf9 \uc790\uae30\uacf5\uba85\uc758 \uc2ec\uc7a5 \uc751\uc6a9<\/span>.\u00a0<span class=\"ref-journal\">\uc74c\uc2dd\ubb3c. \ud575. Magn. Reson. Spectrosc.<\/span>\u00a0<span class=\"ref-vol\">106-107<\/span>, 66\u201387. 10.1016\/j.pnmrs.2018.05.002 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31047602\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1016%2Fj.pnmrs.2018.05.002\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Prog.+Nucl.+Magn.+Reson.+Spectrosc.&amp;title=Cardiac+applications+of+hyperpolarised+magnetic+resonance&amp;author=K.+N.+Timm&amp;author=J.+J.+Miller&amp;author=J.+A.+Henry&amp;author=D.+J.+Tyler&amp;volume=106-107&amp;publication_year=2018&amp;pages=66-87&amp;pmid=31047602&amp;doi=10.1016\/j.pnmrs.2018.05.002&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B45\"><span class=\"mixed-citation\">Vejpongsa P., Yeh ET (2014).\u00a0<span class=\"ref-title\">\uc548\ud2b8\ub77c\uc0ac\uc774\ud074\ub9b0 \uc720\ubc1c \uc2ec\uc7a5 \ub3c5\uc131 \uc608\ubc29: \uacfc\uc81c\uc640 \uae30\ud68c<\/span>.\u00a0<span class=\"ref-journal\">J.Am. \ucf5c. \uce74\ub514\uc62c.<\/span>\u00a0<span class=\"ref-vol\">64<\/span>\u00a0(<span class=\"ref-iss\">9<\/span>), 938-945. 10.1016\/j.jacc.2014.06.1167 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25169180\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1016%2Fj.jacc.2014.06.1167\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.+Am.+Coll.+Cardiol.&amp;title=Prevention+of+anthracycline-induced+cardiotoxicity:+Challenges+and+opportunities&amp;author=P.+Vejpongsa&amp;author=E.+T.+Yeh&amp;volume=64&amp;issue=9&amp;publication_year=2014&amp;pages=938-945&amp;pmid=25169180&amp;doi=10.1016\/j.jacc.2014.06.1167&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B46\"><span class=\"mixed-citation\">Venturini M., Michelotti A., Del Mastro L., Gallo L., Carnino F., Garrone O. \ub4f1 (1996).\u00a0<span class=\"ref-title\">\uc9c4\ud589\uc131 \uc720\ubc29\uc554\uc5d0 \ub300\ud574 \uc5d0\ud53c\ub8e8\ube44\uc2e0 \ud654\ud559\uc694\ubc95\uc744 \ubc1b\uace0 \uc788\ub294 \uc5ec\uc131\uc744 \ub300\uc0c1\uc73c\ub85c \ub371\uc2a4\ub77c\uc871\uc0b0\uc758 \uc2ec\uc7a5 \ubcf4\ud638 \ud6a8\uacfc\uc640 \uc2ec\uc7a5 \ubcf4\ud638 \uc694\ubc95\uc744 \uc0ac\uc6a9\ud558\uc9c0 \uc54a\ub294 \ubc29\ubc95\uc744 \ud3c9\uac00\ud558\uae30 \uc704\ud55c \ub2e4\uae30\uad00 \ubb34\uc791\uc704 \ub300\uc870 \uc784\uc0c1 \uc2dc\ud5d8<\/span>.\u00a0<span class=\"ref-journal\">J. \ud074\ub9b0. \uc628\ucf5c.<\/span>\u00a0<span class=\"ref-vol\">14<\/span>\u00a0(<span class=\"ref-iss\">12<\/span>), 3112-3120. 10.1200\/JCO.1996.14.12.3112 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8955656\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1200%2FJCO.1996.14.12.3112\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.+Clin.+Oncol.&amp;title=Multicenter+randomized+controlled+clinical+trial+to+evaluate+cardioprotection+of+dexrazoxane+versus+no+cardioprotection+in+women+receiving+epirubicin+chemotherapy+for+advanced+breast+cancer&amp;author=M.+Venturini&amp;author=A.+Michelotti&amp;author=L.+Del+Mastro&amp;author=L.+Gallo&amp;author=F.+Carnino&amp;volume=14&amp;issue=12&amp;publication_year=1996&amp;pages=3112-3120&amp;pmid=8955656&amp;doi=10.1200\/JCO.1996.14.12.3112&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B47\"><span class=\"mixed-citation\">\uc640\ud0c0\ub098\ubca0 H., \ub85c\uc988 MT, \uc544\uc18c H. (2011).\u00a0<span class=\"ref-title\">\ud3ec\ub3c4\ub2f9\uacfc \uc9c0\uc9c8 \ub300\uc0ac\uc5d0\uc11c \ub9d0\ucd08 \uc138\ub85c\ud1a0\ub2cc\uc758 \uc5ed\ud560<\/span>.\u00a0<span class=\"ref-journal\">\ud604\uc7ac \uc758\uacac. \ub9ac\ud53c\ub3cc.<\/span>\u00a0<span class=\"ref-vol\">22<\/span>\u00a0(<span class=\"ref-iss\">3<\/span>), 186-191. 10.1097\/MOL.0b013e3283462273 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21494145\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1097%2FMOL.0b013e3283462273\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Curr.+Opin.+Lipidol.&amp;title=Role+of+peripheral+serotonin+in+glucose+and+lipid+metabolism&amp;author=H.+Watanabe&amp;author=M.+T.+Rose&amp;author=H.+Aso&amp;volume=22&amp;issue=3&amp;publication_year=2011&amp;pages=186-191&amp;pmid=21494145&amp;doi=10.1097\/MOL.0b013e3283462273&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B48\"><span class=\"mixed-citation\">Wen L., He T., Yu A., Sun S., Li X., Wei J., \uc678. (2021).\u00a0<span class=\"ref-title\">\ube0c\ub808\ube44\uc2a4\uce74\ud540: \uc2dd\ubb3c\ud654\ud559, \uc57d\ub3d9\ud559 \ubc0f \uce58\ub8cc \ud6a8\uacfc\uc5d0 \ub300\ud55c \uac80\ud1a0<\/span>.\u00a0<span class=\"ref-journal\">\uc624\uc804. J. \uce5c. \uba54\ub4dc.<\/span>\u00a0<span class=\"ref-vol\">49<\/span>\u00a0(<span class=\"ref-iss\">6<\/span>), 1369-1397. 10.1142\/S0192415X21500646 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34263720\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1142%2FS0192415X21500646\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Am.+J.+Chin.+Med.&amp;title=Breviscapine:+A+review+on+its+phytochemistry,+pharmacokinetics+and+therapeutic+effects&amp;author=L.+Wen&amp;author=T.+He&amp;author=A.+Yu&amp;author=S.+Sun&amp;author=X.+Li&amp;volume=49&amp;issue=6&amp;publication_year=2021&amp;pages=1369-1397&amp;pmid=34263720&amp;doi=10.1142\/S0192415X21500646&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B49\"><span class=\"mixed-citation\">Wilkins HM, Weidling IW, Ji Y., Swerdlow RH (2017).\u00a0<span class=\"ref-title\">\uc2e0\uacbd\ud1f4\ud589\uc758 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc720\ub798 \uc190\uc0c1 \uad00\ub828 \ubd84\uc790 \ud328\ud134<\/span>.\u00a0<span class=\"ref-journal\">\uc55e\ucabd. \uba74\uc5ed.<\/span>\u00a0<span class=\"ref-vol\">8<\/span>, 508.10.3389\/fimmu.2017.00508\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5405073\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28491064\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.3389%2Ffimmu.2017.00508\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Front.+Immunol.&amp;title=Mitochondria-derived+damage-associated+molecular+patterns+in+neurodegeneration&amp;author=H.+M.+Wilkins&amp;author=I.+W.+Weidling&amp;author=Y.+Ji&amp;author=R.+H.+Swerdlow&amp;volume=8&amp;publication_year=2017&amp;pages=508&amp;pmid=28491064&amp;doi=10.3389\/fimmu.2017.00508&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B50\"><span class=\"mixed-citation\">Wu L., Gao Y., Zhang S., Fang Z. (2019).\u00a0<span class=\"ref-title\">\uace0\ud608\uc555 \uc720\ubc1c \uc2e0\uc190\uc0c1 \ud658\uc790\uc758 \uace0\ud608\uc555\uc5d0 \ub300\ud55c \ube0c\ub808\ube44\uc2a4\uce74\ud540 \uc8fc\uc0ac\uc758 \ud6a8\uacfc: \uccb4\uacc4\uc801 \uace0\ucc30 \ubc0f \uba54\ud0c0\ubd84\uc11d<\/span>.\u00a0<span class=\"ref-journal\">\uc55e\ucabd. Pharmacol.<\/span>\u00a0<span class=\"ref-vol\">10<\/span>, 118.10.3389\/fphar.2019.00118\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6394135\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30846938\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.3389%2Ffphar.2019.00118\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Front.+Pharmacol.&amp;title=The+effects+of+breviscapine+injection+on+hypertension+in+hypertension-induced+renal+damage+patients:+A+systematic+review+and+a+meta-analysis&amp;author=L.+Wu&amp;author=Y.+Gao&amp;author=S.+Zhang&amp;author=Z.+Fang&amp;volume=10&amp;publication_year=2019&amp;pages=118&amp;pmid=30846938&amp;doi=10.3389\/fphar.2019.00118&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B51\"><span class=\"mixed-citation\">Xia G., Han Y., Meng F., He Y., Srisai D., Farias M., \uc678. (2021).\u00a0<span class=\"ref-title\">GABA\uc640 \uc138\ub85c\ud1a0\ub2cc \uc2e0\uacbd\ud68c\ub85c\ub97c \ud1b5\ud55c \ube44\ub9cc\uacfc \ubd88\uc548\uc6b0\uc6b8 \uc7a5\uc560\uc758 \uc0c1\ud638 \uc870\uc808<\/span>.\u00a0<span class=\"ref-journal\">\ubab0. \uc815\uc2e0\uacfc<\/span>\u00a0<span class=\"ref-vol\">26<\/span>\u00a0(<span class=\"ref-iss\">7<\/span>), 2837-2853. 10.1038\/s41380-021-01053-w\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8505263\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33767348\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1038%2Fs41380-021-01053-w\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Mol.+Psychiatry&amp;title=Reciprocal+control+of+obesity+and+anxiety-depressive+disorder+via+a+GABA+and+serotonin+neural+circuit&amp;author=G.+Xia&amp;author=Y.+Han&amp;author=F.+Meng&amp;author=Y.+He&amp;author=D.+Srisai&amp;volume=26&amp;issue=7&amp;publication_year=2021&amp;pages=2837-2853&amp;pmid=33767348&amp;doi=10.1038\/s41380-021-01053-w&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B52\"><span class=\"mixed-citation\">Xie S., Sun W., Zhang C., Dong B., Yang J., Hou M., et al. (2021).\u00a0<span class=\"ref-title\">\ud6a8\uacfc\uc801\uc778 \uc554 \uce58\ub8cc\ub97c \uc704\ud55c \uc5f4 \uc2a4\ud2b8\ub808\uc2a4\uc5d0 \uc758\ud55c \ub300\uc0ac \uc870\uc808\ub85c \uc138\ud3ec\uc758 \uc6b4\uba85\uc744 \ud398\ub86d\ud1a0\uc2dc\uc2a4\ub85c \uacb0\uc815<\/span>.\u00a0<span class=\"ref-journal\">ACS\ub098\ub178<\/span>\u00a0<span class=\"ref-vol\">15<\/span>\u00a0(<span class=\"ref-iss\">4<\/span>), 7179-7194. 10.1021\/acsnano.1c00380 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33861924\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1021%2Facsnano.1c00380\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=ACS+Nano&amp;title=Metabolic+control+by+heat+stress+determining+cell+fate+to+ferroptosis+for+effective+cancer+therapy&amp;author=S.+Xie&amp;author=W.+Sun&amp;author=C.+Zhang&amp;author=B.+Dong&amp;author=J.+Yang&amp;volume=15&amp;issue=4&amp;publication_year=2021&amp;pages=7179-7194&amp;pmid=33861924&amp;doi=10.1021\/acsnano.1c00380&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B53\"><span class=\"mixed-citation\">Yabut JM, Crane JD, Green AE, Keating DJ, Khan WI, Steinberg GR(2019).\u00a0<span class=\"ref-title\">\uc2e0\uc9c4\ub300\uc0ac \uc870\uc808\uc5d0\uc11c \uc138\ub85c\ud1a0\ub2cc\uc758 \uc0c8\ub85c\uc6b4 \uc5ed\ud560: \uace0\ub300 \ubd84\uc790\uc5d0 \ub300\ud55c \uc0c8\ub85c\uc6b4 \uc758\ubbf8<\/span>.\u00a0<span class=\"ref-journal\">\uc5d4\ub3c4\ud06c. \uc2e0\ubd80\ub2d8.<\/span>\u00a0<span class=\"ref-vol\">40<\/span>\u00a0(<span class=\"ref-iss\">4<\/span>), 1092-1107. 10.1210\/er.2018-00283\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6624793\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30901029\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1210%2Fer.2018-00283\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Endocr.+Rev.&amp;title=Emerging+roles+for+serotonin+in+regulating+metabolism:+New+implications+for+an+ancient+molecule&amp;author=J.+M.+Yabut&amp;author=J.+D.+Crane&amp;author=A.+E.+Green&amp;author=D.+J.+Keating&amp;author=W.+I.+Khan&amp;volume=40&amp;issue=4&amp;publication_year=2019&amp;pages=1092-1107&amp;pmid=30901029&amp;doi=10.1210\/er.2018-00283&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B54\"><span class=\"mixed-citation\">\uc57c\ub9c8\ubaa8\ud1a0 T., \uc0ac\ub178 M. (2022).\u00a0<span class=\"ref-title\">\uc2ec\ubd80\uc804\uc73c\ub85c \uc778\ud55c \uc2ec\uadfc\uc9c0\ubc29\uc0b0 \ub300\uc0ac \uc7a5\uc560<\/span>.\u00a0<span class=\"ref-journal\">\uad6d\uc81c J.Mol. \uacfc\ud559.<\/span>\u00a0<span class=\"ref-vol\">23<\/span>\u00a0(<span class=\"ref-iss\">2<\/span>), 996.10.3390\/ijms23020996\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8779056\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35055179\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.3390%2Fijms23020996\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Int.+J.+Mol.+Sci.&amp;title=Deranged+myocardial+fatty+acid+metabolism+in+heart+failure&amp;author=T.+Yamamoto&amp;author=M.+Sano&amp;volume=23&amp;issue=2&amp;publication_year=2022&amp;pages=996&amp;pmid=35055179&amp;doi=10.3390\/ijms23020996&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B55\"><span class=\"mixed-citation\">Ye J., Gao M., Guo X., Zhang H., Jiang F. (2020).\u00a0<span class=\"ref-title\">\ube0c\ub808\ube44\uc2a4\uce74\ud540\uc740 PAQR4 \ub9e4\uac1c PI3K\/Akt \uacbd\ub85c \uc870\uc808\uc744 \ud1b5\ud574 \uc804\ub9bd\uc120\uc554\uc758 \uc131\uc7a5\uacfc \uc804\uc774\ub97c \uc5b5\uc81c\ud569\ub2c8\ub2e4.<\/span>.\u00a0<span class=\"ref-journal\">\ubc14\uc774\uc624\uba54\ub4dc. \uc57d\uc0ac.<\/span>\u00a0<span class=\"ref-vol\">127<\/span>, 110223.10.1016\/j.biopha.2020.110223 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32413672\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1016%2Fj.biopha.2020.110223\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Biomed.+Pharmacother.&amp;title=Breviscapine+suppresses+the+growth+and+metastasis+of+prostate+cancer+through+regulating+PAQR4-mediated+PI3K\/Akt+pathway&amp;author=J.+Ye&amp;author=M.+Gao&amp;author=X.+Guo&amp;author=H.+Zhang&amp;author=F.+Jiang&amp;volume=127&amp;publication_year=2020&amp;pages=110223&amp;pmid=32413672&amp;doi=10.1016\/j.biopha.2020.110223&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B56\"><span class=\"mixed-citation\">Zemdegs J., Quesseveur G., Jarriault D., Penicaud L., Fioramonti X., Guiard BP (2016).\u00a0<span class=\"ref-title\">\uace0\uc9c0 \ubc29\uc2dd\uc73c\ub85c \uc778\ud55c \ub300\uc0ac \uc7a5\uc560\ub294 \uc0dd\uc950\uc758 5-HT \uae30\ub2a5\uacfc \ubd88\uc548\uacfc \uac19\uc740 \ud589\ub3d9\uc744 \uc190\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4<\/span>.\u00a0<span class=\"ref-journal\">\ube0c\ub974. J. Pharmacol.<\/span>\u00a0<span class=\"ref-vol\">173<\/span>\u00a0(<span class=\"ref-iss\">13<\/span>), 2095-2110. 10.1111\/bph.13343\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4908198\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26472268\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1111%2Fbph.13343\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Br.+J.+Pharmacol.&amp;title=High-fat+diet-induced+metabolic+disorders+impairs+5-HT+function+and+anxiety-like+behavior+in+mice&amp;author=J.+Zemdegs&amp;author=G.+Quesseveur&amp;author=D.+Jarriault&amp;author=L.+Penicaud&amp;author=X.+Fioramonti&amp;volume=173&amp;issue=13&amp;publication_year=2016&amp;pages=2095-2110&amp;pmid=26472268&amp;doi=10.1111\/bph.13343&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<li id=\"B57\"><span class=\"mixed-citation\">Zhu Y., Pereira RO, O&#039;Neill BT, Riehle C., Ilkun O., Wende AR, \uc678. (2013).\u00a0<span class=\"ref-title\">\uc2ec\uc7a5 PI3K-Akt\ub294 mTORC1 \ubc0f GLUT4 \uc804\uc88c\uc640 \uad00\uacc4\uc5c6\uc774 \uc778\uc290\ub9b0 \uc790\uadf9 \ud3ec\ub3c4\ub2f9 \uc12d\ucde8\ub97c \uc190\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4<\/span>.\u00a0<span class=\"ref-journal\">\ubab0. \ub0b4\ubd84\ube44\ub180.<\/span>\u00a0<span class=\"ref-vol\">27<\/span>\u00a0(<span class=\"ref-iss\">1<\/span>), 172-184. 10.1210\/me.2012-1210\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3545208\/\">PMC \ubb34\ub8cc \uae30\uc0ac<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23204326\">\ud37c\ube0c\uba54\ub4dc<\/a>] [<a href=\"https:\/\/doi.org\/10.1210%2Fme.2012-1210\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Mol.+Endocrinol.&amp;title=Cardiac+PI3K-Akt+impairs+insulin-stimulated+glucose+uptake+independent+of+mTORC1+and+GLUT4+translocation&amp;author=Y.+Zhu&amp;author=R.+O.+Pereira&amp;author=B.+T.+O%27Neill&amp;author=C.+Riehle&amp;author=O.+Ilkun&amp;volume=27&amp;issue=1&amp;publication_year=2013&amp;pages=172-184&amp;pmid=23204326&amp;doi=10.1210\/me.2012-1210&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\uad6c\uae00 \ud559\uc220\uac80\uc0c9<\/a>]<\/span><\/span><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#:~:text=Interestingly%2C%20breviscapine%20increases%20the%20efficiency,heart%20and%20reducing%20lipid%20oxidation\">\uc6d0\ucc9c<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\uad11\ubc94\uc704\ud55c \ud56d\uc554\uc81c\uc778 \ub3c5\uc18c\ub8e8\ube44\uc2e0(Dox)\uc740 \uc2ec\uc7a5\ub3c5\uc131 \ubc1c\uc0dd\ub960\uc774 \ub192\uc544 \uc57d\ubb3c\uc758 \uc784\uc0c1 \uc801\uc6a9\uacfc \ud658\uc790\uc758 \uc0b6\uc758 \uc9c8\uc5d0 \uc2ec\uac01\ud55c \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4. \uc5ec\uae30\uc5d0\uc11c\ub294 Dox\uac00 \uc2ec\uadfc \uc5d0\ub108\uc9c0\uc640 \uc218\ucd95 \uae30\ub2a5\uc744 \uc5b4\ub5bb\uac8c \uc870\uc808\ud558\ub294\uc9c0 \ud3c9\uac00\ud558\uace0 \uc774\ub294 \uad00\ub828 \ubcf4\ud638 \uc57d\ubb3c \uac1c\ubc1c\uc5d0 \ub3c4\uc6c0\uc774 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>","protected":false},"author":1,"featured_media":5375,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9],"tags":[],"class_list":["post-5177","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-supplements"],"_links":{"self":[{"href":"https:\/\/directcm.com\/ko\/wp-json\/wp\/v2\/posts\/5177","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/directcm.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/directcm.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/directcm.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/directcm.com\/ko\/wp-json\/wp\/v2\/comments?post=5177"}],"version-history":[{"count":1,"href":"https:\/\/directcm.com\/ko\/wp-json\/wp\/v2\/posts\/5177\/revisions"}],"predecessor-version":[{"id":5387,"href":"https:\/\/directcm.com\/ko\/wp-json\/wp\/v2\/posts\/5177\/revisions\/5387"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/directcm.com\/ko\/wp-json\/wp\/v2\/media\/5375"}],"wp:attachment":[{"href":"https:\/\/directcm.com\/ko\/wp-json\/wp\/v2\/media?parent=5177"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/directcm.com\/ko\/wp-json\/wp\/v2\/categories?post=5177"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/directcm.com\/ko\/wp-json\/wp\/v2\/tags?post=5177"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}