{"id":4897,"date":"2024-01-15T06:31:30","date_gmt":"2024-01-15T06:31:30","guid":{"rendered":"https:\/\/corp.farlong.com\/the-effect-of-proto-type-wearable-light-emitting-devices-on-serum-25-hydroxyvitamin-d-levels-in-healthy-adults-a-4-week-randomized-controlled-trial\/"},"modified":"2024-01-27T10:17:53","modified_gmt":"2024-01-27T10:17:53","slug":"the-effect-of-proto-type-wearable-light-emitting-devices-on-serum-25-hydroxyvitamin-d-levels-in-healthy-adults-a-4-week-randomized-controlled-trial","status":"publish","type":"post","link":"https:\/\/directcm.com\/vi\/the-effect-of-proto-type-wearable-light-emitting-devices-on-serum-25-hydroxyvitamin-d-levels-in-healthy-adults-a-4-week-randomized-controlled-trial\/","title":{"rendered":"T\u00e1c d\u1ee5ng c\u1ee7a c\u00e1c thi\u1ebft b\u1ecb ph\u00e1t s\u00e1ng c\u00f3 th\u1ec3 \u0111eo \u0111\u01b0\u1ee3c ki\u1ec3u nguy\u00ean m\u1eabu \u0111\u1ed1i v\u1edbi n\u1ed3ng \u0111\u1ed9 25-hydroxyv vitamin D trong huy\u1ebft thanh \u1edf ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh kh\u1ecfe m\u1ea1nh: th\u1eed nghi\u1ec7m ng\u1eabu nhi\u00ean c\u00f3 \u0111\u1ed1i ch\u1ee9ng k\u00e9o d\u00e0i 4 tu\u1ea7n"},"content":{"rendered":"
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D\u00e2n s\u1ed1 nghi\u00ean c\u1ee9u<\/h3>\n

Nghi\u00ean c\u1ee9u n\u00e0y \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n t\u1ea1i ph\u00f2ng kh\u00e1m gi\u1ea5c ng\u1ee7 c\u1ee7a B\u1ec7nh vi\u1ec7n Bundang thu\u1ed9c \u0110\u1ea1i h\u1ecdc Qu\u1ed1c gia Seoul (SNUBH), Seongnam, H\u00e0n Qu\u1ed1c. Nh\u1eefng ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh kh\u1ecfe m\u1ea1nh, \u1edf \u0111\u1ed9 tu\u1ed5i 20\u201365, \u0111\u00e3 \u0111\u01b0\u1ee3c tuy\u1ec3n d\u1ee5ng th\u00f4ng qua c\u00e1c qu\u1ea3ng c\u00e1o trong c\u1ed9ng \u0111\u1ed3ng \u0111\u1ecba ph\u01b0\u01a1ng t\u1eeb th\u00e1ng 8 n\u0103m 2020 \u0111\u1ebfn th\u00e1ng 8 n\u0103m 2021. Nh\u1eefng ng\u01b0\u1eddi tham gia \u0111\u00e3 \u0111\u0103ng k\u00fd \u0111\u00e3 tr\u1ea3i qua c\u00e1c x\u00e9t nghi\u1ec7m s\u00e0ng l\u1ecdc trong l\u1ea7n kh\u00e1m \u0111\u1ea7u ti\u00ean, trong v\u00f2ng m\u1ed9t tu\u1ea7n tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u can thi\u1ec7p. Nh\u1eefng ng\u01b0\u1eddi g\u1eb7p ph\u1ea3i ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i tr\u00ean da trong th\u1eed nghi\u1ec7m s\u00e0ng l\u1ecdc \u0111\u00e3 b\u1ecb lo\u1ea1i tr\u1eeb. Ch\u00fang t\u00f4i c\u0169ng lo\u1ea1i tr\u1eeb nh\u1eefng ng\u01b0\u1eddi \u0111\u00e1p \u1ee9ng c\u00e1c ti\u00eau ch\u00ed sau: (1) ti\u1ec1n s\u1eed tr\u1ecb li\u1ec7u b\u1eb1ng \u00e1nh s\u00e1ng ho\u1eb7c b\u1ed5 sung vitamin D trong v\u00f2ng hai th\u00e1ng tr\u01b0\u1edbc khi tham gia nghi\u00ean c\u1ee9u; (2) c\u00e1c b\u1ec7nh v\u1ec1 da bao g\u1ed3m ung th\u01b0 da v\u00e0 nh\u1ea1y c\u1ea3m v\u1edbi \u00e1nh s\u00e1ng; (3) c\u00e1c b\u1ec7nh n\u1ed9i khoa nh\u01b0 b\u1ec7nh \u00e1c t\u00ednh, b\u1ec7nh v\u1ec1 \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p, b\u1ec7nh truy\u1ec1n nhi\u1ec5m, suy gan ho\u1eb7c th\u1eadn v\u00e0 ch\u1ea5n th\u01b0\u01a1ng \u0111\u1ea7u; v\u00e0 (4) r\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n bao g\u1ed3m r\u1ed1i lo\u1ea1n t\u00e2m tr\u1ea1ng, r\u1ed1i lo\u1ea1n lo \u00e2u, r\u1ed1i lo\u1ea1n gi\u1ea5c ng\u1ee7 v\u00e0 r\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n. C\u00f3 s\u1ef1 \u0111\u1ed3ng \u00fd b\u1eb1ng v\u0103n b\u1ea3n t\u1eeb t\u1ea5t c\u1ea3 nh\u1eefng ng\u01b0\u1eddi tham gia tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u nghi\u00ean c\u1ee9u. Nghi\u00ean c\u1ee9u n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t b\u1edfi H\u1ed9i \u0111\u1ed3ng \u0110\u00e1nh gi\u00e1 Th\u1ec3 ch\u1ebf c\u1ee7a SNUBH (B-2002-597-003) v\u00e0 \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u0103ng k\u00fd v\u1edbi D\u1ecbch v\u1ee5 Th\u00f4ng tin Nghi\u00ean c\u1ee9u L\u00e2m s\u00e0ng (CRIS), H\u00e0n Qu\u1ed1c (s\u1ed1 \u0111\u0103ng k\u00fd KCT0007033).<\/p>\n

S\u1ef1 can thi\u1ec7p<\/h3>\n

Ch\u00fang t\u00f4i \u0111\u00e3 s\u1eed d\u1ee5ng hai lo\u1ea1i thi\u1ebft b\u1ecb ph\u00e1t s\u00e1ng c\u00f3 th\u1ec3 \u0111eo \u0111\u01b0\u1ee3c nguy\u00ean m\u1eabu kh\u00e1c nhau (thi\u1ebft b\u1ecb ho\u1ea1t \u0111\u1ed9ng v\u00e0 thi\u1ebft b\u1ecb gi\u1ea3), \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf ri\u00eang t\u1ea1i Tr\u01b0\u1eddng K\u1ef9 thu\u1eadt \u0110i\u1ec7n, Vi\u1ec7n Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 Ti\u00ean ti\u1ebfn H\u00e0n Qu\u1ed1c, Daejeon, H\u00e0n Qu\u1ed1c. Thi\u1ebft b\u1ecb ho\u1ea1t \u0111\u1ed9ng bao g\u1ed3m 48 \u0111\u00e8n LED (QD Jason, Trung Qu\u1ed1c, Model J35ABA285P09A) ph\u00e1t ra \u00e1nh s\u00e1ng UVB \u1edf b\u01b0\u1edbc s\u00f3ng c\u1ef1c \u0111\u1ea1i 285 nm v\u1edbi to\u00e0n b\u1ed9 chi\u1ec1u r\u1ed9ng \u1edf m\u1ee9c c\u1ef1c \u0111\u1ea1i m\u1ed9t n\u1eeda l\u00e0 11 nm. C\u00e1c \u0111\u00e8n LED \u0111\u01b0\u1ee3c b\u1ed1 tr\u00ed tr\u00ean m\u1ed9t b\u1ea3ng m\u1ea1ch in linh ho\u1ea1t (FPCB) \u1edf \u0111\u1ecbnh d\u1ea1ng ma tr\u1eadn 6 \u00d7 8 v\u1edbi kho\u1ea3ng c\u00e1ch 13 mm gi\u1eefa c\u00e1c \u0111\u00e8n LED li\u1ec1n k\u1ec1. Sau \u0111\u00f3, FPCB v\u1edbi 48 \u0111\u00e8n LED UVB n\u00e0y \u0111\u01b0\u1ee3c \u0111\u1eb7t trong v\u1ecf in 3-D c\u00f3 th\u1ec3 qu\u1ea5n quanh ph\u1ea7n d\u01b0\u1edbi ho\u1eb7c ph\u1ea7n tr\u00ean c\u1ee7a c\u00e1nh tay. Kho\u1ea3ng c\u00e1ch gi\u1eefa \u0111\u00e8n LED v\u00e0 b\u1ec1 m\u1eb7t da \u0111\u01b0\u1ee3c chi\u1ebfu s\u00e1ng \u0111\u01b0\u1ee3c duy tr\u00ec \u1edf m\u1ee9c ~5 mm \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o \u00e1nh s\u00e1ng t\u1eeb \u0111\u00e8n LED c\u00f3 th\u1ec3 lan t\u1ecfa tr\u00ean da. H\u01a1n n\u1eefa, m\u1ed9t ch\u1ea5t \u0111\u00e0n h\u1ed3i trong su\u1ed1t c\u1ee7a polydimethylsiloxane (PDMS) \u0111\u01b0\u1ee3c \u0111\u1eb7t gi\u1eefa \u0111\u00e8n LED v\u00e0 b\u1ec1 m\u1eb7t da \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o kho\u1ea3ng c\u00e1ch gi\u1eefa da v\u1edbi \u0111\u00e8n LED kh\u00f4ng \u0111\u1ed5i. M\u1ed9t m\u1eb7t c\u1ee7a l\u1edbp PDMS c\u00f3 c\u1ea5u tr\u00fac vi m\u00f4 \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng h\u01a1n n\u1eefa s\u1ef1 lan t\u1ecfa c\u1ee7a \u00e1nh s\u00e1ng LED. Di\u1ec7n t\u00edch \u0111\u01b0\u1ee3c chi\u1ebfu s\u00e1ng t\u1ed5ng th\u1ec3 l\u00e0 ~ 80 cm2<\/sup>. C\u1ea5u tr\u00fac khu\u1ebfch t\u00e1n \u00e1nh s\u00e1ng c\u00f3 th\u1ec3 duy tr\u00ec li\u1ec1u l\u01b0\u1ee3ng ~7,8 mJ\/cm2<\/sup> m\u1ed7i l\u1ea7n ti\u1ebfp x\u00fac m\u1ed9t ph\u00fat. C\u00e1c thi\u1ebft b\u1ecb gi\u1ea3 c\u00f3 c\u1ea5u tr\u00fac gi\u1ed1ng h\u1ec7t nhau ngo\u1ea1i tr\u1eeb \u0111\u00e8n LED ph\u00e1t ra \u00e1nh s\u00e1ng xanh v\u1edbi b\u01b0\u1edbc s\u00f3ng c\u1ef1c \u0111\u1ea1i l\u00e0 465 nm thay v\u00ec \u00e1nh s\u00e1ng UVB (H\u00ecnh 2). 1<\/a>).<\/p>\n

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H\u00ecnh 1: \u1ea2nh ch\u1ee5p c\u00e1c thi\u1ebft b\u1ecb \u0111eo nguy\u00ean m\u1eabu.<\/b><\/figcaption>
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\"figure<\/picture><\/a><\/div>\n
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M\u1ed9t<\/b> H\u00ecnh \u1ea3nh thi\u1ebft b\u1ecb \u0111eo tia c\u1ef1c t\u00edm B \u0111\u01b0\u1ee3c \u0111\u1ec1 xu\u1ea5t v\u1edbi b\u1ed9 \u0111i\u1ec1u khi\u1ec3n t\u00f9y ch\u1ec9nh. b<\/b> H\u00ecnh \u1ea3nh thi\u1ebft b\u1ecb \u0111eo tia c\u1ef1c t\u00edm B \u0111eo \u1edf c\u1eb3ng tay.<\/p>\n<\/div>\n<\/div>\n<\/figure>\n<\/div>\n

\u1ede l\u1ea7n kh\u00e1m \u0111\u1ea7u ti\u00ean, m\u1ed9t th\u1eed nghi\u1ec7m s\u00e0ng l\u1ecdc \u0111\u00e3 \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng m\u1ed9t thi\u1ebft b\u1ecb th\u1eed nghi\u1ec7m l\u00e0m b\u1eb1ng m\u1ed9t \u0111\u00e8n LED duy nh\u1ea5t, ph\u00e1t ra \u00e1nh s\u00e1ng UVB c\u00f3 c\u00f9ng b\u01b0\u1edbc s\u00f3ng v\u00e0 c\u01b0\u1eddng \u0111\u1ed9 nh\u01b0 thi\u1ebft b\u1ecb \u0111ang ho\u1ea1t \u0111\u1ed9ng, tr\u00ean m\u1ed9t m\u00e0n h\u00ecnh 3 cm.2<\/sup> v\u00f9ng da c\u1eb3ng tay. Sau \u0111\u00f3, nh\u1eefng ng\u01b0\u1eddi tham gia \u0111\u1ee7 \u0111i\u1ec1u ki\u1ec7n \u0111\u01b0\u1ee3c ph\u00e2n ng\u1eabu nhi\u00ean theo t\u1ef7 l\u1ec7 1:1 v\u00e0o nh\u00f3m th\u1eed nghi\u1ec7m ho\u1eb7c nh\u00f3m \u0111\u1ed1i ch\u1ee9ng v\u00e0 kh\u00f4ng \u0111\u01b0\u1ee3c ph\u00e2n c\u00f4ng can thi\u1ec7p. Vi\u1ec7c ph\u00e2n c\u00f4ng ng\u1eabu nhi\u00ean \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n b\u1edfi b\u00ean th\u1ee9 ba, th\u00f4ng qua ph\u01b0\u01a1ng ph\u00e1p ng\u1eabu nhi\u00ean h\u00f3a kh\u1ed1i ho\u00e1n v\u1ecb ph\u00e2n t\u1ea7ng. \u1ede l\u1ea7n truy c\u1eadp th\u1ee9 hai, di\u1ec5n ra trong v\u00f2ng m\u1ed9t tu\u1ea7n sau l\u1ea7n truy c\u1eadp \u0111\u1ea7u ti\u00ean, nh\u1eefng ng\u01b0\u1eddi tham gia \u0111\u00e3 nh\u1eadn \u0111\u01b0\u1ee3c thi\u1ebft b\u1ecb \u0111ang ho\u1ea1t \u0111\u1ed9ng ho\u1eb7c thi\u1ebft b\u1ecb gi\u1ea3 t\u00f9y thu\u1ed9c v\u00e0o s\u1ef1 ph\u00e2n c\u00f4ng nh\u00f3m ng\u1eabu nhi\u00ean c\u1ee7a h\u1ecd. H\u1ecd \u0111\u01b0\u1ee3c h\u01b0\u1edbng d\u1eabn \u0111eo thi\u1ebft b\u1ecb n\u00e0y t\u1ed5ng c\u1ed9ng 2 ph\u00fat, 1 ph\u00fat tr\u00ean m\u1ed7i c\u1eb3ng tay m\u1ed7i ng\u00e0y trong 4 tu\u1ea7n. M\u1ed9t ph\u00fat ti\u1ebfp x\u00fac v\u1edbi tia c\u1ef1c t\u00edm tr\u00ean m\u1ed7i c\u00e1nh tay \u0111\u01b0\u1ee3c \u0111i\u1ec1u khi\u1ec3n b\u1edfi b\u1ed9 \u0111i\u1ec1u khi\u1ec3n c\u1ee7a thi\u1ebft b\u1ecb. Theo \u0111\u00f3, li\u1ec1u h\u00e0ng ng\u00e0y tr\u00ean m\u1ed9t \u0111\u01a1n v\u1ecb di\u1ec7n t\u00edch b\u1ee9c x\u1ea1 UVB c\u1ee7a thi\u1ebft b\u1ecb ho\u1ea1t \u0111\u1ed9ng \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh l\u00e0 kho\u1ea3ng 7,8 mJ\/cm2<\/sup>v\u00e0 di\u1ec7n t\u00edch ph\u01a1i nhi\u1ec5m hi\u1ec7u qu\u1ea3 l\u00e0 ~ 80 cm2<\/sup> cho m\u1ed7i c\u1eb3ng tay, t\u1ed5ng li\u1ec1u h\u00e0ng ng\u00e0y l\u00e0 1,25 J (=7,8 mJ\/cm2<\/sup> \u00d7 80 cm2<\/sup>\u00d7 2). V\u00ec s\u1ef1 an to\u00e0n c\u1ee7a nh\u1eefng ng\u01b0\u1eddi tham gia, ch\u00fang t\u00f4i \u0111\u00e3 theo d\u00f5i s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a b\u1ea5t k\u1ef3 t\u00e1c d\u1ee5ng ph\u1ee5 n\u00e0o v\u00e0 vi\u1ec7c tu\u00e2n th\u1ee7 s\u1eed d\u1ee5ng thi\u1ebft b\u1ecb \u1edf l\u1ea7n kh\u00e1m th\u1ee9 ba v\u00e0 th\u1ee9 t\u01b0, di\u1ec5n ra l\u1ea7n l\u01b0\u1ee3t 2 v\u00e0 4 tu\u1ea7n sau khi b\u1eaft \u0111\u1ea7u can thi\u1ec7p. N\u1ebfu x\u1ea3y ra b\u1ea5t k\u1ef3 ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i \u0111\u00e1ng ng\u1edd n\u00e0o tr\u00ean da bao g\u1ed3m ban \u0111\u1ecf ho\u1eb7c ph\u00e1t ban sau khi can thi\u1ec7p, vi\u1ec7c s\u1eed d\u1ee5ng thi\u1ebft b\u1ecb s\u1ebd ngay l\u1eadp t\u1ee9c b\u1ecb ng\u1eebng v\u00e0 ng\u01b0\u1eddi tham gia s\u1ebd b\u1ecb r\u00fat kh\u1ecfi th\u1eed nghi\u1ec7m.<\/p>\n

\u0110o n\u1ed3ng \u0111\u1ed9 25-hydroxyvitamin D trong huy\u1ebft thanh<\/h3>\n

Ch\u00fang t\u00f4i s\u1eed d\u1ee5ng n\u1ed3ng \u0111\u1ed9 25-hydroxyv vitamin D [25(OH)D] huy\u1ebft thanh l\u00e0m ch\u1ec9 s\u1ed1 v\u1ec1 t\u00ecnh tr\u1ea1ng dinh d\u01b0\u1ee1ng vitamin D huy\u1ebft thanh v\u00ec n\u00f3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i \u0111\u1ec3 \u0111o l\u01b0\u1eddng t\u00ecnh tr\u1ea1ng dinh d\u01b0\u1ee1ng vitamin D huy\u1ebft thanh [17<\/a>]. N\u1ed3ng \u0111\u1ed9 25(OH)D trong huy\u1ebft thanh \u0111\u01b0\u1ee3c \u0111o b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p s\u1eafc k\u00fd l\u1ecfng-s\u1eafc k\u00fd song song-kh\u1ed1i ph\u1ed5 hi\u1ec7u n\u0103ng cao. Vitamin D \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a qua gan v\u00e0 th\u1eadn v\u00e0 qu\u00e1 tr\u00ecnh trao \u0111\u1ed5i ch\u1ea5t c\u1ee7a n\u00f3 li\u00ean quan \u0111\u1ebfn canxi v\u00e0 ph\u1ed1t ph\u00e1t trong huy\u1ebft thanh [18<\/a>]. Do \u0111\u00f3, n\u1ed3ng \u0111\u1ed9 canxi, phosphat, alanine transaminase, aspartate aminotransferase, phosphatase ki\u1ec1m, gamma-glutamyl transpeptidase, bilirubin to\u00e0n ph\u1ea7n, creatinine v\u00e0 nit\u01a1 ur\u00ea trong huy\u1ebft thanh c\u0169ng \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 \u0111\u1ed3ng th\u1eddi v\u1edbi ph\u00e9p \u0111o 25(OH)D huy\u1ebft thanh. X\u00e9t nghi\u1ec7m m\u00e1u \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh b\u1ed1n l\u1ea7n, \u1edf l\u1ea7n kh\u00e1m \u0111\u1ea7u ti\u00ean (ban \u0111\u1ea7u), l\u1ea7n th\u1ee9 ba (tu\u1ea7n 2), l\u1ea7n th\u1ee9 t\u01b0 (tu\u1ea7n 4) v\u00e0 l\u1ea7n kh\u00e1m cu\u1ed1i c\u00f9ng. Chuy\u1ebfn th\u0103m cu\u1ed1i c\u00f9ng \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n hai tu\u1ea7n sau khi k\u1ebft th\u00fac can thi\u1ec7p (tu\u1ea7n 6). T\u1ea5t c\u1ea3 c\u00e1c m\u1eabu m\u00e1u \u0111\u01b0\u1ee3c thu v\u00e0o ban ng\u00e0y (t\u1eeb 9h30 s\u00e1ng \u0111\u1ebfn 4h chi\u1ec1u), trong t\u00ecnh tr\u1ea1ng kh\u00f4ng nh\u1ecbn \u0111\u00f3i v\u00e0 \u0111\u01b0\u1ee3c x\u1eed l\u00fd \u0111\u00fang quy c\u00e1ch v\u00e0 v\u1eadn chuy\u1ec3n \u0111\u1ebfn vi\u1ec7n x\u00e9t nghi\u1ec7m (Ph\u00f2ng th\u00ed nghi\u1ec7m l\u00e2m s\u00e0ng Seoul, Seoul, H\u00e0n Qu\u1ed1c) . T\u1ea5t c\u1ea3 c\u00e1c x\u00e9t nghi\u1ec7m m\u00e1u \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n v\u00e0o c\u00f9ng m\u1ed9t th\u1eddi \u0111i\u1ec3m trong ng\u00e0y cho m\u1ed7i ng\u01b0\u1eddi tham gia. Ngo\u00e0i ra, m\u00f9a m\u00e0 nh\u1eefng ng\u01b0\u1eddi tham gia tham gia nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c coi l\u00e0 m\u1ed9t y\u1ebfu t\u1ed1 g\u00e2y nhi\u1ec5u do s\u1ef1 thay \u0111\u1ed5i theo m\u00f9a c\u1ee7a n\u1ed3ng \u0111\u1ed9 25(OH)D huy\u1ebft thanh \u1edf ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh H\u00e0n Qu\u1ed1c [19<\/a>]. Nh\u1eefng ng\u01b0\u1eddi tham gia nghi\u00ean c\u1ee9u c\u1ee7a ch\u00fang t\u00f4i \u0111\u01b0\u1ee3c ph\u00e2n th\u00e0nh b\u1ed1n nh\u00f3m theo m\u00f9a \u0111\u0103ng k\u00fd h\u1ecdc: nh\u00f3m m\u00f9a xu\u00e2n (th\u00e1ng 3 \u0111\u1ebfn th\u00e1ng 5), nh\u00f3m m\u00f9a h\u00e8 (th\u00e1ng 6 \u0111\u1ebfn th\u00e1ng 8), nh\u00f3m m\u00f9a thu (th\u00e1ng 9 \u0111\u1ebfn th\u00e1ng 11) v\u00e0 nh\u00f3m m\u00f9a \u0111\u00f4ng (th\u00e1ng 12 \u0111\u1ebfn th\u00e1ng 2).<\/p>\n

\u0110\u1eb7c \u0111i\u1ec3m d\u00e2n s\u1ed1<\/h3>\n

Th\u00f4ng tin nh\u00e2n kh\u1ea9u h\u1ecdc, bao g\u1ed3m tu\u1ed5i t\u00e1c, gi\u1edbi t\u00ednh, ch\u1ec9 s\u1ed1 kh\u1ed1i c\u01a1 th\u1ec3, t\u00ecnh tr\u1ea1ng h\u00f4n nh\u00e2n, tr\u00ecnh \u0111\u1ed9 h\u1ecdc v\u1ea5n, t\u00ecnh tr\u1ea1ng h\u00fat thu\u1ed1c hi\u1ec7n t\u1ea1i, th\u00f3i quen u\u1ed1ng r\u01b0\u1ee3u v\u00e0 m\u1ee9c \u0111\u1ed9 ho\u1ea1t \u0111\u1ed9ng th\u1ec3 ch\u1ea5t, \u0111\u01b0\u1ee3c l\u1ea5y \u1edf l\u1ea7n kh\u00e1m \u0111\u1ea7u ti\u00ean. V\u1ec1 th\u00f3i quen u\u1ed1ng r\u01b0\u1ee3u, nh\u1eefng ng\u01b0\u1eddi tham gia \u0111\u01b0\u1ee3c x\u1ebfp v\u00e0o nh\u00f3m t\u00edch c\u1ef1c n\u1ebfu h\u1ecd \u0111\u00e3 u\u1ed1ng r\u01b0\u1ee3u \u00edt nh\u1ea5t m\u1ed9t l\u1ea7n trong th\u00e1ng qua. Li\u00ean quan \u0111\u1ebfn m\u1ee9c \u0111\u1ed9 ho\u1ea1t \u0111\u1ed9ng th\u1ec3 ch\u1ea5t, nh\u1eefng ng\u01b0\u1eddi th\u1ef1c hi\u1ec7n b\u1ea5t k\u1ef3 lo\u1ea1i b\u00e0i t\u1eadp n\u00e0o trong \u00edt nh\u1ea5t 30 ph\u00fat m\u1ed7i b\u00e0i, ba l\u1ea7n m\u1ed9t tu\u1ea7n \u0111\u01b0\u1ee3c ph\u00e2n lo\u1ea1i l\u00e0 t\u00edch c\u1ef1c.<\/p>\n

Dinh d\u01b0\u1ee1ng v\u00e0 ho\u1ea1t \u0111\u1ed9ng ngo\u00e0i tr\u1eddi<\/h3>\n

N\u1ed3ng \u0111\u1ed9 25(OH)D trong huy\u1ebft thanh c\u00f3 th\u1ec3 b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t vitamin D c\u1ee7a da th\u00f4ng qua vi\u1ec7c ti\u1ebfp x\u00fac v\u1edbi \u00e1nh n\u1eafng m\u1eb7t tr\u1eddi ho\u1eb7c b\u1ed5 sung ch\u1ebf \u0111\u1ed9 \u0103n u\u1ed1ng. Do \u0111\u00f3, ch\u00fang t\u00f4i \u0111\u00e3 ki\u1ec3m tra l\u01b0\u1ee3ng vitamin D \u0103n v\u00e0o h\u00e0ng ng\u00e0y v\u00e0 th\u1eddi gian d\u00e0nh cho b\u1ea5t k\u1ef3 ho\u1ea1t \u0111\u1ed9ng ngo\u00e0i tr\u1eddi n\u00e0o v\u00e0o l\u00fac 2 v\u00e0 4 tu\u1ea7n can thi\u1ec7p v\u00e0 2 tu\u1ea7n sau khi k\u1ebft th\u00fac can thi\u1ec7p. T\u1ea5t c\u1ea3 nh\u1eefng ng\u01b0\u1eddi tham gia \u0111\u01b0\u1ee3c h\u01b0\u1edbng d\u1eabn ghi nh\u1eadt k\u00fd h\u00e0ng ng\u00e0y v\u1ec1 ch\u1ebf \u0111\u1ed9 \u0103n u\u1ed1ng v\u00e0 m\u1ee9c \u0111\u1ed9 ho\u1ea1t \u0111\u1ed9ng ngo\u00e0i tr\u1eddi c\u1ee7a h\u1ecd trong su\u1ed1t 4 tu\u1ea7n c\u1ee7a th\u1eddi gian can thi\u1ec7p v\u00e0 2 tu\u1ea7n b\u1ed5 sung sau khi k\u1ebft th\u00fac can thi\u1ec7p. Ch\u00fang t\u00f4i c\u0169ng t\u00ednh to\u00e1n l\u01b0\u1ee3ng vitamin D ti\u00eau th\u1ee5 trung b\u00ecnh h\u00e0ng ng\u00e0y trong ch\u1ebf \u0111\u1ed9 \u0103n u\u1ed1ng v\u00e0 th\u1eddi gian d\u00e0nh cho c\u00e1c ho\u1ea1t \u0111\u1ed9ng ngo\u00e0i tr\u1eddi t\u1eeb khi b\u1eaft \u0111\u1ea7u can thi\u1ec7p cho \u0111\u1ebfn m\u1ed7i l\u1ea7n \u0111\u00e1nh gi\u00e1.<\/p>\n

Ph\u00e2n t\u00edch th\u1ed1ng k\u00ea<\/h3>\n

Ch\u00fang t\u00f4i \u0111\u00e3 t\u00ednh to\u00e1n c\u1ee1 m\u1eabu y\u00eau c\u1ea7u t\u1ed1i thi\u1ec3u l\u00e0 128 \u0111\u1ed1i t\u01b0\u1ee3ng (64 \u0111\u1ed1i t\u01b0\u1ee3ng cho m\u1ed7i nh\u00f3m), s\u1eed d\u1ee5ng ph\u1ea7n m\u1ec1m G*Power \u1edf m\u1ee9c tin c\u1eady 95%, c\u1ee1 hi\u1ec7u \u1ee9ng l\u00e0 0,5 v\u00e0 c\u00f4ng su\u1ea5t th\u1ed1ng k\u00ea l\u00e0 0,8. K\u00edch th\u01b0\u1edbc hi\u1ec7u \u1ee9ng 0,5 \u0111\u00e3 \u0111\u01b0\u1ee3c th\u00f4ng qua v\u00ec n\u00f3 \u0111\u1ea1i di\u1ec7n cho k\u00edch th\u01b0\u1edbc hi\u1ec7u \u1ee9ng \u201ctrung b\u00ecnh\u201d. Xem x\u00e9t t\u1ef7 l\u1ec7 b\u1ecf h\u1ecdc l\u00e0 15%, ch\u00fang t\u00f4i quy\u1ebft \u0111\u1ecbnh \u0111\u0103ng k\u00fd kh\u00f4ng d\u01b0\u1edbi 150 \u0111\u1ed1i t\u01b0\u1ee3ng (75 \u0111\u1ed1i t\u01b0\u1ee3ng trong m\u1ed7i nh\u00f3m). Trong nghi\u00ean c\u1ee9u hi\u1ec7n t\u1ea1i, ph\u00e2n t\u00edch theo giao th\u1ee9c (PP) \u0111\u00e3 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n sau khi lo\u1ea1i tr\u1eeb d\u1eef li\u1ec7u kh\u1ecfi nh\u1eefng ng\u01b0\u1eddi \u0111\u00e3 b\u1ecf h\u1ecdc.<\/p>\n

C\u00e1c \u0111\u1eb7c \u0111i\u1ec3m nh\u00e2n kh\u1ea9u h\u1ecdc c\u01a1 b\u1ea3n \u0111\u01b0\u1ee3c so s\u00e1nh b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng ph\u00e9p th\u1eed t \u0111\u1ed9c l\u1eadp ho\u1eb7c ph\u00e9p th\u1eed Mann Whitney U cho c\u00e1c bi\u1ebfn li\u00ean t\u1ee5c v\u00e0 ph\u00e9p th\u1eed chi b\u00ecnh ph\u01b0\u01a1ng cho c\u00e1c bi\u1ebfn ph\u00e2n lo\u1ea1i gi\u1eefa nh\u00f3m th\u1eed nghi\u1ec7m v\u00e0 nh\u00f3m \u0111\u1ed1i ch\u1ee9ng. \u0110\u1ed1i v\u1edbi nh\u1eefng thay \u0111\u1ed5i so v\u1edbi m\u1ee9c c\u01a1 b\u1ea3n \u1edf m\u1ed7i l\u1ea7n \u0111\u00e1nh gi\u00e1 m\u1ee9c 25(OH)D trong huy\u1ebft thanh, x\u00e9t nghi\u1ec7m t c\u1eb7p \u0111\u00f4i v\u00e0 x\u00e9t nghi\u1ec7m t \u0111\u1ed9c l\u1eadp (ho\u1eb7c Mann Whitney b\u1ea1n<\/i> test) \u0111\u00e3 \u0111\u01b0\u1ee3c th\u00f4ng qua \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 s\u1ef1 kh\u00e1c bi\u1ec7t gi\u1eefa c\u00e1c nh\u00f3m v\u00e0 s\u1ef1 kh\u00e1c bi\u1ec7t gi\u1eefa c\u00e1c nh\u00f3m t\u01b0\u01a1ng \u1ee9ng. M\u1ed9t ph\u00e2n t\u00edch hi\u1ec7p ph\u01b0\u01a1ng sai c\u0169ng \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh \u0111\u1ec3 so s\u00e1nh s\u1ef1 thay \u0111\u1ed5i n\u1ed3ng \u0111\u1ed9 25(OH)D huy\u1ebft thanh sau khi ki\u1ec3m so\u00e1t c\u00e1c y\u1ebfu t\u1ed1 g\u00e2y nhi\u1ec5u c\u00f3 th\u1ec3 x\u1ea3y ra. L\u00e0 m\u1ed9t ph\u00e2n t\u00edch ph\u1ee5 c\u1ee7a nh\u00f3m th\u1eed nghi\u1ec7m, ch\u00fang t\u00f4i \u0111\u00e3 s\u1eed d\u1ee5ng t-test v\u00e0 ANCOVA \u0111\u1ed9c l\u1eadp \u0111\u1ec3 so s\u00e1nh s\u1ef1 thay \u0111\u1ed5i c\u1ee7a n\u1ed3ng \u0111\u1ed9 25(OH)D huy\u1ebft thanh sau 4 tu\u1ea7n can thi\u1ec7p gi\u1eefa nh\u1eefng ng\u01b0\u1eddi b\u1ecb v\u00e0 kh\u00f4ng b\u1ecb thi\u1ebfu vitamin D \u1edf \u0111\u00e1nh gi\u00e1 c\u01a1 b\u1ea3n. Thi\u1ebfu vitamin D \u0111\u01b0\u1ee3c \u0111\u1ecbnh ngh\u0129a l\u00e0 n\u1ed3ng \u0111\u1ed9 25(OH)D huy\u1ebft thanh < 20 ng\/ml [20<\/a>]. T\u1ea5t c\u1ea3 c\u00e1c ph\u00e2n t\u00edch th\u1ed1ng k\u00ea \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n b\u1eb1ng SPSS phi\u00ean b\u1ea3n 25.0 cho Windows (SPSS, Chicago, IL, USA) v\u00e0 m\u00f4 h\u00ecnh hai \u0111u\u00f4i P<\/i> gi\u00e1 tr\u1ecb nh\u1ecf h\u01a1n 0,05 \u0111\u01b0\u1ee3c coi l\u00e0 c\u00f3 \u00fd ngh\u0129a th\u1ed1ng k\u00ea.<\/p>\n<\/div>\n

[qu\u1ea3ng c\u00e1o_2]<\/p>\n

Li\u00ean k\u1ebft ngu\u1ed3n <\/a><\/p>","protected":false},"excerpt":{"rendered":"

At the first visit, a screening test was conducted using a testing device made of a single LED, which emitted UVB light with the same wavelength and intensity as the active device, onto a 3-cm2 area of forearm skin.<\/p>","protected":false},"author":1,"featured_media":5359,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9],"tags":[],"class_list":["post-4897","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-supplements"],"_links":{"self":[{"href":"https:\/\/directcm.com\/vi\/wp-json\/wp\/v2\/posts\/4897","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/directcm.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/directcm.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/directcm.com\/vi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/directcm.com\/vi\/wp-json\/wp\/v2\/comments?post=4897"}],"version-history":[{"count":1,"href":"https:\/\/directcm.com\/vi\/wp-json\/wp\/v2\/posts\/4897\/revisions"}],"predecessor-version":[{"id":5381,"href":"https:\/\/directcm.com\/vi\/wp-json\/wp\/v2\/posts\/4897\/revisions\/5381"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/directcm.com\/vi\/wp-json\/wp\/v2\/media\/5359"}],"wp:attachment":[{"href":"https:\/\/directcm.com\/vi\/wp-json\/wp\/v2\/media?parent=4897"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/directcm.com\/vi\/wp-json\/wp\/v2\/categories?post=4897"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/directcm.com\/vi\/wp-json\/wp\/v2\/tags?post=4897"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}