{"id":5081,"date":"2024-01-15T12:21:35","date_gmt":"2024-01-15T12:21:35","guid":{"rendered":"https:\/\/www.farlong.com\/?p=5081"},"modified":"2024-01-27T10:42:32","modified_gmt":"2024-01-27T10:42:32","slug":"therapeutic-effects-of-breviscapine-in-cardiovascular-diseases-a-review","status":"publish","type":"post","link":"https:\/\/directcm.com\/vi\/therapeutic-effects-of-breviscapine-in-cardiovascular-diseases-a-review\/","title":{"rendered":"T\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb c\u1ee7a Breviscapine trong c\u00e1c b\u1ec7nh tim m\u1ea1ch: \u0110\u00e1nh gi\u00e1"},"content":{"rendered":"
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\u0110i \u0111\u1ebfn:<\/a><\/div>\n
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tr\u1eebu t\u01b0\u1ee3ng<\/h2>\n
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Breviscapine l\u00e0 m\u1ed9t chi\u1ebft xu\u1ea5t th\u00f4 c\u1ee7a m\u1ed9t s\u1ed1 flavonoid c\u1ee7a <\/span>Erigeron breviscapus (Vant.) Hand.-Mazz.<\/em>, ch\u1ee9a h\u01a1n 85% scutellarin, \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng theo truy\u1ec1n th\u1ed1ng \u1edf Trung Qu\u1ed1c nh\u01b0 m\u1ed9t lo\u1ea1i thu\u1ed1c k\u00edch ho\u1ea1t tu\u1ea7n ho\u00e0n m\u00e1u \u0111\u1ec3 c\u1ea3i thi\u1ec7n vi\u1ec7c cung c\u1ea5p m\u00e1u n\u00e3o. Thu th\u1eadp b\u1eb1ng ch\u1ee9ng t\u1eeb nhi\u1ec1u n\u01a1i\u00a0<\/span>trong c\u01a1 th\u1ec3 s\u1ed1ng<\/em>\u00a0V\u00e0\u00a0<\/span>trong \u1ed1ng nghi\u1ec7m<\/em>\u00a0c\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng breviscapine c\u00f3 nhi\u1ec1u t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd v\u1ec1 tim m\u1ea1ch, bao g\u1ed3m gi\u00e3n m\u1ea1ch, b\u1ea3o v\u1ec7 ch\u1ed1ng thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9\/t\u00e1i t\u01b0\u1edbi m\u00e1u (I\/R), ch\u1ed1ng vi\u00eam, ch\u1ed1ng \u0111\u00f4ng m\u00e1u, ch\u1ed1ng huy\u1ebft kh\u1ed1i, b\u1ea3o v\u1ec7 n\u1ed9i m\u00f4, b\u1ea3o v\u1ec7 c\u01a1 tim, gi\u1ea3m s\u1ef1 di chuy\u1ec3n v\u00e0 t\u0103ng sinh t\u1ebf b\u00e0o c\u01a1 tr\u01a1n , t\u00e1i t\u1ea1o c\u01a1 tim, ch\u1ed1ng lo\u1ea1n nh\u1ecbp tim, gi\u1ea3m lipid m\u00e1u v\u00e0 c\u1ea3i thi\u1ec7n ch\u1ee9ng r\u1ed1i lo\u1ea1n c\u01b0\u01a1ng d\u01b0\u01a1ng. Ngo\u00e0i ra, m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng \u0111\u00e3 b\u00e1o c\u00e1o r\u1eb1ng breviscapine c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng k\u1ebft h\u1ee3p v\u1edbi thu\u1ed1c T\u00e2y \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh tim m\u1ea1ch (CVD) bao g\u1ed3m b\u1ec7nh tim m\u1ea1ch v\u00e0nh, nh\u1ed3i m\u00e1u c\u01a1 tim, t\u0103ng huy\u1ebft \u00e1p, rung t\u00e2m nh\u0129, t\u0103ng lipid m\u00e1u, vi\u00eam c\u01a1 tim do virus, suy tim m\u00e3n t\u00ednh v\u00e0 b\u1ec7nh tim ph\u1ed5i. . Tuy nhi\u00ean, t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 c\u1ee7a breviscapine \u0111\u1ed1i v\u1edbi CVD d\u1ef1a tr\u00ean c\u00e1c nghi\u00ean c\u1ee9u th\u1ef1c nghi\u1ec7m c\u00f9ng v\u1edbi c\u00e1c c\u01a1 ch\u1ebf c\u01a1 b\u1ea3n c\u1ee7a n\u00f3 ch\u01b0a \u0111\u01b0\u1ee3c xem x\u00e9t m\u1ed9t c\u00e1ch c\u00f3 h\u1ec7 th\u1ed1ng. B\u00e0i vi\u1ebft n\u00e0y \u0111\u00e3 xem x\u00e9t c\u00e1c c\u01a1 ch\u1ebf d\u01b0\u1ee3c l\u00fd c\u01a1 b\u1ea3n v\u1ec1 t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 tim m\u1ea1ch c\u1ee7a breviscapine v\u00e0 l\u00e0m s\u00e1ng t\u1ecf c\u00e1c \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng c\u1ee7a n\u00f3.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n

T\u1eeb kh\u00f3a:\u00a0<\/strong>breviscapine, y h\u1ecdc Trung Qu\u1ed1c, d\u00e2n t\u1ed9c h\u1ecdc, thu\u1ed1c th\u1ea3o d\u01b0\u1ee3c, ho\u1ea1t ch\u1ea5t th\u1ea3o d\u01b0\u1ee3c<\/span><\/div>\n
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\u0110i \u0111\u1ebfn:<\/a><\/div>\n

Gi\u1edbi thi\u1ec7u<\/h2>\n

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Erigeron breviscapus<\/em>\u00a0(Erigeron breviscapus (Vant.) Hand.-Mazz.<\/em>), c\u00f2n \u0111\u01b0\u1ee3c bi\u1ebft l\u00e0\u00a0Th\u1ea3o m\u1ed9c Erigerontis<\/em>\u00a0ho\u1eb7c\u00a0\u0110\u00e8n hoa c\u00fac<\/em>, l\u00e0 m\u1ed9t lo\u1ea1i th\u1ea3o m\u1ed9c truy\u1ec1n th\u1ed1ng c\u1ee7a Trung Qu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng h\u01a1n 600 n\u0103m, \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y \u1edf V\u00e2n Nam, T\u1ee9 Xuy\u00ean, Qu\u00fd Ch\u00e2u v\u00e0 c\u00e1c t\u1ec9nh ph\u00eda t\u00e2y nam kh\u00e1c c\u1ee7a Trung Qu\u1ed1c. N\u00f3 thu\u1ed9c h\u1ecd c\u00fac, l\u00e0 m\u1ed9t lo\u1ea1i th\u1ea3o d\u01b0\u1ee3c l\u00e2u n\u0103m, m\u1ecdc th\u00e0nh b\u1ee5i, c\u00f3 th\u1ec3 cao t\u1edbi 50 cm (20 inch), m\u1eb7c d\u00f9 trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p, n\u00f3 c\u00f3 th\u1ec3 cao ch\u01b0a \u0111\u1ebfn 1 cm (0,4 inch). Ngo\u00e0i ra, \u0111\u1ea7u hoa c\u1ee7a n\u00f3 c\u00f3 c\u00e1c hoa tia m\u00e0u xanh, t\u00edm ho\u1eb7c tr\u1eafng bao quanh c\u00e1c hoa h\u00ecnh \u0111\u0129a m\u00e0u v\u00e0ng (nh\u01b0 minh h\u1ecda trong h\u00ecnh).\u00a0Nh\u00e2n v\u00e2\u0323t\u00a0\u200bH\u00ecnh 1<\/span>1<\/a><\/strong>). To\u00e0n c\u00e2y ph\u01a1i kh\u00f4\u00a0Erigeron breviscapus<\/em>\u00a0\u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong y h\u1ecdc d\u00e2n gian \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb t\u00ea li\u1ec7t, th\u1ea5p kh\u1edbp, vi\u00eam d\u1ea1 d\u00e0y, \u0111au r\u0103ng v\u00e0 s\u1ed1t (Vi\u1ec7n D\u01b0\u1ee3c li\u1ec7u V\u00e2n Nam, 1976<\/a>).<\/p>\n

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\"An<\/div>\n
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H\u00ccNH 1<\/a><\/div>\n
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Erigeron breviscapus (A)<\/strong>\u00a0hoa;\u00a0(B)<\/strong>\u00a0to\u00e0n b\u1ed9 nh\u00e0 m\u00e1y.<\/p>\n<\/div>\n<\/div>\n<\/div>\n

Breviscapine l\u00e0 m\u1ed9t chi\u1ebft xu\u1ea5t th\u00f4 c\u1ee7a m\u1ed9t s\u1ed1 flavonoid c\u1ee7a\u00a0Erigeron breviscapus (Vant.) Hand.-Mazz.<\/em>\u00a0(Zhang v\u00e0 c\u1ed9ng s\u1ef1, 1988<\/a>) c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c b\u00e0o ch\u1ebf th\u00e0nh nhi\u1ec1u d\u1ea1ng kh\u00e1c nhau bao g\u1ed3m thu\u1ed1c ti\u00eam, h\u1ea1t, vi\u00ean n\u00e9n th\u00f4ng th\u01b0\u1eddng, vi\u00ean n\u00e9n ph\u00e2n t\u00e1n, vi\u00ean nang, h\u1ed7n h\u1ee3p, thu\u1ed1c nh\u1ecf gi\u1ecdt (Tian v\u00e0 c\u1ed9ng s\u1ef1, 2014<\/a>). Theo hi\u1ec3u bi\u1ebft t\u1ed1t nh\u1ea5t c\u1ee7a ch\u00fang t\u00f4i, th\u00e0nh ph\u1ea7n ho\u1ea1t ch\u1ea5t ch\u00ednh c\u1ee7a breviscapine l\u00e0 scutellarin (Zhang v\u00e0 c\u1ed9ng s\u1ef1, 1988<\/a>). Vi\u1ec7c s\u1eed d\u1ee5ng breviscapine \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p, t\u1eafc m\u1ea1ch n\u00e3o v\u00e0 li\u1ec7t do tai bi\u1ebfn m\u1ea1ch m\u00e1u n\u00e3o \u0111\u00e3 c\u00f3 t\u1eeb nh\u1eefng n\u0103m 1970 (Vi\u1ec7n D\u01b0\u1ee3c li\u1ec7u V\u00e2n Nam, 1976<\/a>). C\u00e1c nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y cho th\u1ea5y breviscapine c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb nh\u1ed3i m\u00e1u n\u00e3o v\u00e0 b\u1ec7nh th\u1eadn do ti\u1ec3u \u0111\u01b0\u1eddng. M\u1ed9t ph\u00e2n t\u00edch t\u1ed5ng h\u1ee3p c\u00e1c th\u1eed nghi\u1ec7m ng\u1eabu nhi\u00ean v\u00e0 b\u00e1n ng\u1eabu nhi\u00ean c\u00f3 \u0111\u1ed1i ch\u1ee9ng \u0111\u00e3 so s\u00e1nh breviscapine c\u1ed9ng v\u1edbi li\u1ec7u ph\u00e1p th\u00f4ng th\u01b0\u1eddng v\u1edbi li\u1ec7u ph\u00e1p th\u00f4ng th\u01b0\u1eddng \u0111\u01a1n thu\u1ea7n v\u00e0 cho th\u1ea5y l\u1ee3i \u00edch c\u00f3 \u00fd ngh\u0129a th\u1ed1ng k\u00ea c\u1ee7a vi\u1ec7c s\u1eed d\u1ee5ng breviscapine \u0111\u1ed1i v\u1edbi k\u1ebft qu\u1ea3 c\u1ee7a b\u1ec7nh nh\u00e2n, v\u1edbi s\u1ef1 c\u1ea3i thi\u1ec7n th\u1ea7n kinh r\u00f5 r\u1ec7t (Yang v\u00e0 c\u1ed9ng s\u1ef1, 2012<\/a>). Trong khi \u0111\u00f3, m\u1ed9t ph\u00e2n t\u00edch t\u1ed5ng h\u1ee3p kh\u00e1c v\u1ec1 li\u1ec7u ph\u00e1p k\u1ebft h\u1ee3p breviscapine v\u1edbi mecobalamin cho b\u1ec7nh l\u00fd th\u1ea7n kinh ngo\u1ea1i bi\u00ean do ti\u1ec3u \u0111\u01b0\u1eddng cho th\u1ea5y hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb c\u1ee7a s\u1ef1 k\u1ebft h\u1ee3p n\u00e0y v\u01b0\u1ee3t tr\u1ed9i h\u01a1n so v\u1edbi ch\u1ec9 d\u00f9ng mecobalamin (L\u01b0u v\u00e0 c\u1ed9ng s\u1ef1, 2016<\/a>). M\u1ed9t ph\u00e2n t\u00edch t\u1ed5ng h\u1ee3p kh\u00e1c v\u1ec1 t\u00e1c d\u1ee5ng c\u1ee7a vi\u1ec7c ti\u00eam breviscapine l\u00ean c\u00e1c th\u00f4ng s\u1ed1 l\u00e2m s\u00e0ng c\u1ee7a b\u1ec7nh th\u1eadn \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng (Zheng v\u00e0 c\u1ed9ng s\u1ef1, 2015<\/a>) \u0111\u00e3 t\u00ecm th\u1ea5y t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 th\u1eadn \u0111\u00e1ng k\u1ec3 (gi\u1ea3m protein trong n\u01b0\u1edbc ti\u1ec3u, creatinine huy\u1ebft thanh v\u00e0 nit\u01a1 ur\u00ea trong m\u00e1u) v\u00e0 \u0111i\u1ec1u ch\u1ec9nh r\u1ed1i lo\u1ea1n lipid m\u00e1u (t\u00e1c \u0111\u1ed9ng l\u00ean m\u1ee9c cholesterol, ch\u1ea5t b\u00e9o trung t\u00ednh (TG) v\u00e0 lipoprotein m\u1eadt \u0111\u1ed9 cao).<\/p>\n

Hi\u1ec7n nay, do t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd tim m\u1ea1ch c\u1ee7a n\u00f3 (Nh\u1eefng c\u00e1i b\u00e0n\u00a0\u200bB\u1ea3ng 1,<\/span>1<\/a>,\u00a0\u200b,2<\/span>2<\/a><\/strong>) v\u00e0 l\u1ee3i \u00edch l\u00e2m s\u00e0ng (B\u00e0n\u00a0\u200bB\u00e0n s\u1ed1 3<\/span>3<\/a><\/strong>breviscapine \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i k\u1ebft h\u1ee3p v\u1edbi y h\u1ecdc ph\u01b0\u01a1ng T\u00e2y \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n tim m\u1ea1ch do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9, ch\u1eb3ng h\u1ea1n nh\u01b0 \u0111au th\u1eaft ng\u1ef1c v\u00e0 nh\u1ed3i m\u00e1u c\u01a1 tim (MI), \u1edf Trung Qu\u1ed1c (Cao v\u00e0 c\u1ed9ng s\u1ef1, 2008<\/a>;\u00a0\u00d4ng v\u00e0 c\u1ed9ng s\u1ef1, 2012<\/a>). M\u1ed9t ph\u00e2n t\u00edch t\u1ed5ng h\u1ee3p \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 hi\u1ec7u qu\u1ea3 v\u00e0 \u0111\u1ed9 an to\u00e0n c\u1ee7a breviscapine nh\u01b0 m\u1ed9t li\u1ec7u ph\u00e1p b\u1ed5 tr\u1ee3 cho b\u1ec7nh nh\u00e2n b\u1ecb \u0111au th\u1eaft ng\u1ef1c cho th\u1ea5y r\u1eb1ng so v\u1edbi nh\u00f3m \u0111\u1ed1i ch\u1ee9ng, nh\u00f3m \u0111i\u1ec1u tr\u1ecb v\u01b0\u1ee3t tr\u1ed9i h\u01a1n trong vi\u1ec7c mang l\u1ea1i l\u1ee3i \u00edch cho b\u1ec7nh nh\u00e2n b\u1ecb \u0111au th\u1eaft ng\u1ef1c (Nie v\u00e0 c\u1ed9ng s\u1ef1, 2012<\/a>). Ngo\u00e0i ra, breviscapine \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o l\u00e0 c\u00f3 nhi\u1ec1u t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd tim m\u1ea1ch, bao g\u1ed3m gi\u00e3n m\u1ea1ch, t\u00e1c d\u1ee5ng ch\u1ed1ng huy\u1ebft kh\u1ed1i v\u00e0 k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u, ch\u1ed1ng \u0111\u00f4ng m\u00e1u, lo\u1ea1i b\u1ecf c\u00e1c g\u1ed1c t\u1ef1 do v\u00e0 c\u1ea3i thi\u1ec7n vi tu\u1ea7n ho\u00e0n, th\u00f4ng qua nhi\u1ec1u t\u00e1c d\u1ee5ng kh\u00e1c nhau.\u00a0trong c\u01a1 th\u1ec3 s\u1ed1ng<\/em>\u00a0V\u00e0\u00a0trong \u1ed1ng nghi\u1ec7m<\/em>\u00a0th\u00ed nghi\u1ec7m. Breviscapine c\u00f3 m\u1ed9t lo\u1ea1t c\u00e1c \u0111\u1eb7c t\u00ednh d\u01b0\u1ee3c l\u00fd v\u00e0 l\u00e0 m\u1ed9t lo\u1ea1i h\u1ed7n h\u1ee3p c\u1ee7a m\u1ed9t s\u1ed1 flavonoid c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng, nh\u01b0ng c\u01a1 ch\u1ebf c\u01a1 b\u1ea3n c\u1ee7a n\u00f3 v\u1eabn ch\u01b0a r\u00f5 r\u00e0ng.<\/p>\n

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B\u1ea3ng 1<\/h3>\n
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trong c\u01a1 th\u1ec3 s\u1ed1ng<\/em>\u00a0t\u00e1c d\u1ee5ng tim m\u1ea1ch c\u1ee7a breviscapine v\u00e0 scutellarin.<\/p>\n<\/div>\n

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C\u00e1c hi\u1ec7u \u1ee9ng<\/th>\nC\u00e1c h\u1ee3p ch\u1ea5t<\/th>\n\u0110\u1ed9ng v\u1eadt\/N\u1ed9i t\u1ea1ng<\/th>\nM\u1ee5c ti\u00eau<\/th>\nTh\u1ea9m quy\u1ec1n gi\u1ea3i quy\u1ebft<\/th>\n<\/tr>\n<\/thead>\n
T\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 ch\u1ed1ng l\u1ea1i I\/R<\/td>\nScutellarin\/breviscapin<\/td>\nChu\u1ed9t \u0111\u1ef1c Sprague\u2013Dawley (SD)<\/td>\nNh\u1ed3i m\u00e1u c\u01a1 tim (MI) k\u00edch th\u01b0\u1edbc t\u1ebf b\u00e0o c\u01a1 tim b\u1ecb apoptosis;<\/td>\nLin v\u00e0 c\u1ed9ng s\u1ef1, 2007<\/a><\/td>\n<\/tr>\n
T\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 ch\u1ed1ng l\u1ea1i I\/R<\/td>\nBreviscapine<\/td>\nChu\u1ed9t b\u1ecb th\u01b0\u01a1ng I\/R<\/td>\n\u0110\u01b0\u1eddng d\u1eabn t\u00edn hi\u1ec7u PI3K\/Akt\/eNOS.<\/td>\nWang J. v\u00e0 c\u1ed9ng s\u1ef1, 2015<\/a><\/td>\n<\/tr>\n
T\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 ch\u1ed1ng l\u1ea1i I\/R<\/td>\nBreviscapine<\/td>\nChu\u1ed9t I\/R tim tr\u00e1i<\/td>\nIL-18 v\u00e0 ICAM-1<\/td>\nWang Y. v\u00e0 c\u1ed9ng s\u1ef1, 2013<\/a><\/td>\n<\/tr>\n
T\u00e1c d\u1ee5ng ch\u1ed1ng vi\u00eam<\/td>\nBreviscapine<\/td>\nI\/R c\u01a1 tim \u1edf th\u1ecf New Zealand<\/td>\nProtein TNF-\u03b1 v\u00e0 NF-\u03baB<\/td>\nTri\u1ec7u, 2010<\/a><\/td>\n<\/tr>\n
T\u00e1c d\u1ee5ng ch\u1ed1ng vi\u00eam<\/td>\nBreviscapine<\/td>\nChu\u1ed9t I\/R<\/td>\nProtein TNF-\u03b1 v\u00e0 IL-6<\/td>\nC\u00f4ng v\u00e0 c\u1ed9ng s\u1ef1, 2013<\/a><\/td>\n<\/tr>\n
Thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u<\/td>\nBreviscapine<\/td>\nChu\u1ed9t<\/td>\nTh\u1eddi gian \u0111\u00f4ng m\u00e1u (CT); th\u1eddi gian protrombin (PT); y\u1ebfu t\u1ed1 ti\u1ec3u c\u1ea7u III (PF3); th\u1eddi gian ly gi\u1ea3i euglobulin (ELT)<\/td>\nWang v\u00e0 c\u1ed9ng s\u1ef1, 2003<\/a><\/td>\n<\/tr>\n
t\u00e1c d\u1ee5ng ch\u1ed1ng huy\u1ebft kh\u1ed1i<\/td>\nErigeron breviscapus<\/em>\u00a0flavon<\/td>\nChu\u1ed9t\/th\u1ecf<\/td>\nADP, AA v\u00e0 y\u1ebfu t\u1ed1 k\u00edch ho\u1ea1t ti\u1ec3u c\u1ea7u (PAF)<\/td>\nShen v\u00e0 c\u1ed9ng s\u1ef1, 2000<\/a><\/td>\n<\/tr>\n
t\u00e1c d\u1ee5ng ch\u1ed1ng huy\u1ebft kh\u1ed1i<\/td>\nScutellarein<\/td>\nChu\u1ed9t<\/td>\nTi\u1ec3u c\u1ea7u do ADP g\u00e2y ra<\/td>\nB\u00e0i h\u00e1t v\u00e0 c\u1ed9ng s\u1ef1, 2011<\/a><\/td>\n<\/tr>\n
T\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 n\u1ed9i m\u00f4<\/td>\nThu\u1ed1c ti\u00eam Dengzhan Xixin<\/td>\nChu\u1ed9t Wistar<\/td>\nTNF-\u03b1; ph\u1ea3n \u1ee9ng vi\u00eam<\/td>\nZhang v\u00e0 c\u1ed9ng s\u1ef1, 2009<\/a><\/td>\n<\/tr>\n
T\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 c\u01a1 tim<\/td>\nBreviscapine<\/td>\nPh\u00ec \u0111\u1ea1i tim do qu\u00e1 t\u1ea3i \u00e1p su\u1ea5t \u1edf chu\u1ed9t<\/td>\nT\u00edn hi\u1ec7u ERK1\/2 PI3K\/AKT ph\u1ee5 thu\u1ed9c PKC-alpha<\/td>\nYan v\u00e0 c\u1ed9ng s\u1ef1, 2010<\/a><\/td>\n<\/tr>\n
T\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 c\u01a1 tim<\/td>\nScutellarin<\/td>\nChu\u1ed9t<\/td>\nChuy\u1ec3n ti\u1ebfp n\u1ed9i m\u00f4-trung m\u00f4 tim Con \u0111\u01b0\u1eddng Notch<\/td>\nChu v\u00e0 c\u1ed9ng s\u1ef1, 2014<\/a><\/td>\n<\/tr>\n
T\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 c\u01a1 tim<\/td>\nBreviscapine<\/td>\nChu\u1ed9t m\u1eafc b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng do Streptozotocin g\u00e2y ra<\/td>\nProtein kinase C (PKC); photpholamban (PLB); ch\u1ea5t \u1ee9c ch\u1ebf phosphatase protein-1 (PPI-1); Ca(2+)-ATPase (SERCA-2); th\u1ee5 th\u1ec3 ryanodine (RyR)<\/td>\nWang v\u00e0 c\u1ed9ng s\u1ef1, 2010<\/a><\/td>\n<\/tr>\n
Hi\u1ec7u \u1ee9ng t\u00e1i c\u1ea5u tr\u00fac ch\u1ed1ng tim<\/td>\nBreviscapine<\/td>\nChu\u1ed9t suy tim<\/td>\nCh\u1ee9c n\u0103ng t\u00e2m thu v\u00e0 t\u00e2m tr\u01b0\u01a1ng c\u1ee7a c\u01a1 tim<\/td>\nL\u00fd, 2011<\/a><\/td>\n<\/tr>\n
T\u00e1c d\u1ee5ng h\u1ea1 lipid<\/td>\nBreviscapine<\/td>\nChu\u1ed9t m\u1eafc b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng<\/td>\nLipid m\u00e1u<\/td>\nWei v\u00e0 c\u1ed9ng s\u1ef1, 2010<\/a><\/td>\n<\/tr>\n
T\u00e1c d\u1ee5ng h\u1ea1 lipid<\/td>\nBreviscapine<\/td>\nTh\u1ecf<\/td>\nS\u1ef1 ti\u1ebfn tri\u1ec3n c\u1ee7a t\u0103ng s\u1ea3n n\u1ed9i m\u1ea1c v\u00e0 x\u01a1 v\u1eefa \u0111\u1ed9ng m\u1ea1ch<\/td>\nLou v\u00e0 Liu, 2009<\/a><\/td>\n<\/tr>\n
C\u1ea3i thi\u1ec7n ch\u1ee9c n\u0103ng c\u01b0\u01a1ng d\u01b0\u01a1ng<\/td>\nBreviscapine<\/td>\nChu\u1ed9t t\u0103ng huy\u1ebft \u00e1p t\u1ef1 ph\u00e1t (SHR)<\/td>\nCon \u0111\u01b0\u1eddng RhoA\/Rho-kinase<\/td>\nLi v\u00e0 c\u1ed9ng s\u1ef1, 2014<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n