{"id":5163,"date":"2024-01-16T12:29:30","date_gmt":"2024-01-16T12:29:30","guid":{"rendered":"https:\/\/farlong.com\/?p=5163"},"modified":"2024-01-27T10:12:46","modified_gmt":"2024-01-27T10:12:46","slug":"clinical-benefits-and-pharmacology-of-scutellarin-a-comprehensive-review","status":"publish","type":"post","link":"https:\/\/directcm.com\/vi\/clinical-benefits-and-pharmacology-of-scutellarin-a-comprehensive-review\/","title":{"rendered":"L\u1ee3i \u00edch l\u00e2m s\u00e0ng v\u00e0 d\u01b0\u1ee3c l\u00fd h\u1ecdc c\u1ee7a scutellarin: \u0110\u00e1nh gi\u00e1 to\u00e0n di\u1ec7n"},"content":{"rendered":"
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tr\u1eebu t\u01b0\u1ee3ng<\/h2>\n
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\u0110\u1ed9t qu\u1ef5 v\u00e0 nh\u1ed3i m\u00e1u c\u01a1 tim l\u00e0 m\u1ed9t trong nh\u1eefng nguy\u00ean nh\u00e2n ph\u1ed5 bi\u1ebfn nh\u1ea5t g\u00e2y t\u1eed vong v\u00e0 t\u00e0n t\u1eadt tr\u00ean th\u1ebf gi\u1edbi. T\u1ed5n th\u01b0\u01a1ng do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 ti\u1ec1m \u1ea9n trong nh\u1eefng c\u0103n b\u1ec7nh n\u00e0y r\u1ea5t ph\u1ee9c t\u1ea1p, li\u00ean quan \u0111\u1ebfn s\u1ef1 t\u01b0\u01a1ng t\u00e1c ph\u1ee9c t\u1ea1p gi\u1eefa nhi\u1ec1u ch\u1ee9c n\u0103ng sinh h\u1ecdc bao g\u1ed3m chuy\u1ec3n h\u00f3a n\u0103ng l\u01b0\u1ee3ng, \u0111i\u1ec1u h\u00f2a m\u1ea1ch m\u00e1u, huy\u1ebft \u0111\u1ed9ng h\u1ecdc, stress oxy h\u00f3a, vi\u00eam, k\u00edch ho\u1ea1t ti\u1ec3u c\u1ea7u v\u00e0 s\u1eeda ch\u1eefa m\u00f4 di\u1ec5n ra theo c\u00e1ch ph\u1ee5 thu\u1ed9c v\u00e0o b\u1ed1i c\u1ea3nh v\u00e0 th\u1eddi gian. L\u1ef1a ch\u1ecdn \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c hi\u1ec7n nay l\u00e0 cung c\u1ea5p m\u00e1u k\u1ecbp th\u1eddi cho m\u00f4 thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9; nh\u01b0ng vi\u1ec7c t\u00e1i t\u01b0\u1edbi m\u00e1u c\u00f3 th\u1ec3 g\u00e2y th\u00eam t\u1ed5n h\u1ea1i cho m\u00f4 th\u00f4ng qua m\u1ed9t qu\u00e1 tr\u00ecnh \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 t\u1ed5n th\u01b0\u01a1ng do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9\/t\u00e1i t\u01b0\u1edbi m\u00e1u. Nh\u01b0 v\u1eady, c\u00e1c lo\u1ea1i thu\u1ed1c m\u1edbi s\u1ebd b\u1ed5 sung cho qu\u00e1 tr\u00ecnh t\u00e1i t\u01b0\u1edbi m\u00e1u b\u1eb1ng c\u00e1ch cung c\u1ea5p s\u1ef1 b\u1ea3o v\u1ec7 th\u1ea7n kinh v\u00e0 tim m\u1ea1ch c\u0169ng nh\u01b0 nh\u1eafm m\u1ee5c ti\u00eau\u00a0nhi\u1ec1u b\u1ea5t th\u01b0\u1eddng<\/a>\u00a0TRONG\u00a0thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9<\/a>\u00a0\u0111ang nh\u1eadn \u0111\u01b0\u1ee3c s\u1ef1 quan t\u00e2m ng\u00e0y c\u00e0ng t\u0103ng.\u00a0Scutellarin<\/a>\u00a0l\u00e0 m\u1ed9t lo\u1ea1i th\u1ea3o d\u01b0\u1ee3c\u00a0flavonoid<\/a>\u00a0glucuronid<\/a>\u00a0v\u1edbi nhi\u1ec1u\u00a0ho\u1ea1t \u0111\u1ed9ng d\u01b0\u1ee3c l\u00fd<\/a>. Do c\u00f3 nhi\u1ec1u t\u00e1c d\u1ee5ng c\u00f3 l\u1ee3i nh\u01b0 ch\u1ed1ng oxy h\u00f3a, ch\u1ed1ng vi\u00eam, gi\u00e3n m\u1ea1ch, ch\u1ed1ng ti\u1ec3u c\u1ea7u, ch\u1ed1ng \u0111\u00f4ng m\u00e1u v\u00e0 b\u1ea3o v\u1ec7 c\u01a1 tim, scutellarin \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng l\u00e2m s\u00e0ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb \u0111\u1ed9t qu\u1ef5, nh\u1ed3i m\u00e1u c\u01a1 tim v\u00e0\u00a0bi\u1ebfn ch\u1ee9ng ti\u1ec3u \u0111\u01b0\u1eddng<\/a>. Trong ba th\u1eadp k\u1ef7 qua, c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng v\u00e0 d\u01b0\u1ee3c l\u00fd \u0111\u00e3 t\u00edch l\u0169y \u0111\u01b0\u1ee3c r\u1ea5t nhi\u1ec1u b\u1eb1ng ch\u1ee9ng kh\u00f4ng ch\u1ec9 ch\u1ee9ng minh nh\u1eefng t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb n\u00e0y m\u00e0 c\u00f2n cung c\u1ea5p nh\u1eefng hi\u1ec3u bi\u1ebft s\u00e2u s\u1eafc v\u1ec1 t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c.\u00a0d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/a>\u00a0h\u00e0nh vi, \u0111\u1eb7c t\u00ednh tr\u1ecb li\u1ec7u v\u00e0 ph\u01b0\u01a1ng th\u1ee9c t\u00e1c d\u1ee5ng c\u1ee7a scutellarin \u1edf ng\u01b0\u1eddi v\u00e0 m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt. Vi\u1ec7c s\u1eeda \u0111\u1ed5i thu\u1ed1c v\u00e0 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p ph\u00e2n ph\u1ed1i thu\u1ed1c m\u1edbi \u0111\u00e3 d\u1eabn \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n c\u00e1c d\u1eabn xu\u1ea5t v\u00e0 c\u00f4ng th\u1ee9c m\u1edbi c\u1ee7a scutellarin v\u1edbi kh\u1ea3 d\u1ee5ng sinh h\u1ecdc, hi\u1ec7u qu\u1ea3 v\u00e0 \u0111\u1ed9 an to\u00e0n \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n. \u1ede \u0111\u00e2y ch\u00fang t\u00f4i xem x\u00e9t c\u00e1c t\u00e0i li\u1ec7u hi\u1ec7n t\u1ea1i v\u1ec1 scutellarin \u0111\u1ec3 cung c\u1ea5p s\u1ef1 hi\u1ec3u bi\u1ebft to\u00e0n di\u1ec7n v\u1ec1 t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd, c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng, \u0111\u1ed9c t\u00ednh v\u00e0 ti\u1ec1m n\u0103ng \u0111i\u1ec1u tr\u1ecb c\u1ee7a scutellarin trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh\u00a0thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9<\/a>,\u00a0bi\u1ebfn ch\u1ee9ng ti\u1ec3u \u0111\u01b0\u1eddng<\/a>, v\u00e0 c\u00e1c b\u1ec7nh m\u00e3n t\u00ednh kh\u00e1c.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Gi\u1edbi thi\u1ec7u<\/h2>\n
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Scutellarin l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c flavonoid c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb th\u1ef1c v\u1eadt\u00a0Erigeron breviscapus<\/em>\u00a0(Vant.) Hand.-Mazz., m\u1ed9t lo\u1ea1i thu\u1ed1c th\u1ea3o d\u01b0\u1ee3c Trung Qu\u1ed1c c\u00f3 nhi\u1ec1u t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd v\u00e0 \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng. To\u00e0n b\u1ed9 c\u00e2y \u0111\u01b0\u1ee3c ng\u01b0\u1eddi d\u00e2n t\u1ed9c Yi \u1edf T\u00e2y Nam Trung Qu\u1ed1c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng t\u00ea li\u1ec7t do \u0111\u1ed9t qu\u1ef5 v\u00e0 \u0111au kh\u1edbp do th\u1ea5p kh\u1edbp trong nhi\u1ec1u th\u1ebf h\u1ec7 (Wang, Yang v\u00e0 Yang, 2012). C\u1ea5u tr\u00fac c\u1ee7a scutellarin \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh l\u00e0 li\u00ean h\u1ee3p glucuronide c\u1ee7a 5,6,7,4\u2032-tetrahydroxyflavone (scutellarein, S, C15<\/sub>H10<\/sub>\u1ed36<\/sub>) v\u00e0o l\u00fac 7-\u1ed3<\/em>\u00a0v\u1ecb tr\u00ed (scutellarein-7-\u1ed3<\/em>-glucuronid, S-7-G, C21<\/sub>H18<\/sub>\u1ed312<\/sub>) m\u1ed9t th\u1ebf k\u1ef7 tr\u01b0\u1edbc (H\u00ecnh 1a v\u00e0 b). Tuy nhi\u00ean, nghi\u00ean c\u1ee9u c\u00f3 h\u1ec7 th\u1ed1ng v\u1ec1 scutellarin trong y h\u1ecdc hi\u1ec7n \u0111\u1ea1i ch\u1ec9 b\u1eaft \u0111\u1ea7u v\u00e0o cu\u1ed1i nh\u1eefng n\u0103m 1970, khi Trung Qu\u1ed1c ph\u00e1t \u0111\u1ed9ng m\u1ed9t chi\u1ebfn d\u1ecbch l\u1edbn nh\u1eb1m x\u00e1c \u0111\u1ecbnh v\u00e0 hi\u1ec7n \u0111\u1ea1i h\u00f3a c\u00e1c ph\u01b0\u01a1ng ph\u00e1p tr\u1ecb li\u1ec7u t\u1eeb y h\u1ecdc c\u1ed5 truy\u1ec1n Trung Qu\u1ed1c. Chi\u1ebfn d\u1ecbch n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn l\u00e0 \u0111\u00e3 ph\u00e1t hi\u1ec7n ra m\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c th\u00e0nh c\u00f4ng tr\u00ean l\u00e2m s\u00e0ng, \u0111i\u1ec3n h\u00ecnh nh\u1ea5t l\u00e0 thu\u1ed1c ch\u1ed1ng s\u1ed1t r\u00e9t, Artemisinin, c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb th\u1ea3o d\u01b0\u1ee3c.\u00a0Artemisia h\u00e0ng n\u0103m L.<\/em>\u00a0(T\u1ed5 ch\u1ee9c, 2015). Scutellarin \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh l\u00e0 th\u00e0nh ph\u1ea7n ho\u1ea1t ch\u1ea5t ch\u00ednh c\u1ee7a\u00a0Erigeron breviscapus<\/em>\u00a0t\u1eeb nh\u1eefng nghi\u00ean c\u1ee9u ban \u0111\u1ea7u n\u00e0y (Medica, 1976; Wang v\u00e0 c\u1ed9ng s\u1ef1, 2012). Breviscapine, chi\u1ebft xu\u1ea5t t\u1ed5ng s\u1ed1 flavonoid c\u1ee7a\u00a0E. breviscapus<\/em>\u00a0c\u00f3 h\u00e0m l\u01b0\u1ee3ng \u226590% Scutellarin v\u00e0 \u226410% apigenin-7-O-glucronide, \u0111\u01b0\u1ee3c ph\u00e2n lo\u1ea1i l\u00e0 thu\u1ed1c k\u00ea \u0111\u01a1n. Hi\u1ec7n t\u1ea1i, h\u01a1n m\u01b0\u1eddi tri\u1ec7u b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng breviscapine v\u00e0 c\u00e1c lo\u1ea1i thu\u1ed1c li\u00ean quan m\u1ed7i n\u0103m \u1edf Trung Qu\u1ed1c (Liu v\u00e0 c\u1ed9ng s\u1ef1, 2018).<\/p>\n

Nghi\u00ean c\u1ee9u v\u1ec1 scutellarin trong ba th\u1eadp k\u1ef7 qua \u0111\u00e3 d\u1eabn \u0111\u1ebfn s\u1ef1 t\u00edch l\u0169y m\u1ed9t l\u01b0\u1ee3ng l\u1edbn b\u1eb1ng ch\u1ee9ng ch\u1ee9ng minh t\u00ednh hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh m\u1ea1ch m\u00e1u n\u00e3o v\u00e0 tim m\u1ea1ch, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 v\u00e0 b\u1ec7nh tim m\u1ea1ch v\u00e0nh (\u1ee6y ban D\u01b0\u1ee3c \u0111i\u1ec3n Trung Qu\u1ed1c, 2015; Gao v\u00e0 c\u1ed9ng s\u1ef1, 2017; Yang, Cheng, Xie, Yang v\u00e0 Zhuang, 2012; Yang, Li, Xie, Zhuang v\u00e0 Yang, 2013). C\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng v\u00e0 x\u00e9t nghi\u1ec7m c\u0169ng cho th\u1ea5y scutellarin c\u00f3 th\u1ec3 \u0111i\u1ec1u tr\u1ecb m\u1ed9t s\u1ed1 b\u1ec7nh m\u00e3n t\u00ednh kh\u00e1c, ch\u1eb3ng h\u1ea1n nh\u01b0 bi\u1ebfn ch\u1ee9ng ti\u1ec3u \u0111\u01b0\u1eddng (Li, Wu, v\u00e0 Wang, 2009; Liu v\u00e0 c\u1ed9ng s\u1ef1, 2016; Wu, Zhong, v\u00e0 Sun, 2002; Zheng, Ou, Shen , Chu v\u00e0 Wang, 2015). H\u01a1n n\u1eefa, nh\u1eefng nghi\u00ean c\u1ee9u n\u00e0y ti\u1ebft l\u1ed9 nh\u1eefng hi\u1ec3u bi\u1ebft s\u00e2u s\u1eafc \u0111\u00e1ng k\u1ec3 v\u1ec1 kh\u00eda c\u1ea1nh d\u01b0\u1ee3c l\u00fd c\u1ee7a thu\u1ed1c, bao g\u1ed3m h\u00e0nh vi d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc, ph\u01b0\u01a1ng th\u1ee9c t\u00e1c d\u1ee5ng, m\u1ee5c ti\u00eau thu\u1ed1c v\u00e0 ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i \u1edf c\u1ea3 ng\u01b0\u1eddi v\u00e0 m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt (Gao v\u00e0 c\u1ed9ng s\u1ef1, 2012; Gao, Chen v\u00e0 Zhong , 2011; Li, Lin, Xie, Zhang v\u00e0 Guo, 2015; Li, Wang, Li, Bai v\u00e0 Xue, 2011; Lin v\u00e0 c\u1ed9ng s\u1ef1, 2007; Yuan, Fang, Wu v\u00e0 Ling, 2016; Yuan, Zha , Rangarajan, Ling v\u00e0 Wu, 2014). Ngo\u00e0i ra, nh\u1eefng ti\u1ebfn b\u1ed9 trong c\u00f4ng th\u1ee9c, ph\u00e2n ph\u1ed1i thu\u1ed1c v\u00e0 bi\u1ebfn \u0111\u1ed5i c\u1ea5u tr\u00fac c\u1ee7a scutellarin trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y \u0111\u00e3 m\u1edf ra nh\u1eefng c\u01a1 h\u1ed9i m\u1edbi \u0111\u1ec3 c\u1ea3i thi\u1ec7n sinh kh\u1ea3 d\u1ee5ng, \u0111\u1eb7c \u0111i\u1ec3m \u0111i\u1ec1u tr\u1ecb, hi\u1ec7u qu\u1ea3 v\u00e0 \u0111\u1ed9 an to\u00e0n c\u1ee7a scutellarin (Lu v\u00e0 c\u1ed9ng s\u1ef1, 2010, Lu v\u00e0 c\u1ed9ng s\u1ef1, 2012). ; Wang v\u00e0 c\u1ed9ng s\u1ef1, 2017). Trong b\u00e0i vi\u1ebft n\u00e0y, ch\u00fang t\u00f4i xem x\u00e9t c\u00e1c t\u00e0i li\u1ec7u v\u1ec1 scutellarin nh\u1eb1m cung c\u1ea5p s\u1ef1 hi\u1ec3u bi\u1ebft to\u00e0n di\u1ec7n v\u1ec1 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb, d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc v\u00e0 ho\u1ea1t t\u00ednh d\u01b0\u1ee3c l\u00fd c\u1ee7a thu\u1ed1c.<\/p>\n<\/section>\n<\/div>\n<\/div>\n

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\u0110o\u1ea1n tr\u00edch ph\u1ea7n<\/h2>\n
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T\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb v\u00e0 l\u1ee3i \u00edch l\u00e2m s\u00e0ng<\/h2>\n

Erigeron breviscapus<\/em>\u00a0(Vant.) Hand.-Mazz., c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0\u00a0Th\u1ea3o m\u1ed9c Erigerontis<\/em>,\u00a0\u0110\u00e8n hoa c\u00fac<\/em>v\u00e0 Flebane, hay dengzhanxixin v\u00e0 dengzhanhua trong ti\u1ebfng Trung, \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y \u1edf nhi\u1ec1u khu v\u1ef1c mi\u1ec1n n\u00fai ph\u00eda T\u00e2y Nam Trung Qu\u1ed1c. Ngo\u00e0i vi\u1ec7c \u0111i\u1ec1u tr\u1ecb b\u1ec7nh t\u00ea li\u1ec7t v\u00e0 th\u1ea5p kh\u1edbp c\u1ee7a ng\u01b0\u1eddi Yi, thu\u1ed1c th\u1ea3o d\u01b0\u1ee3c c\u00f2n \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ch\u1eefa \u0111au \u0111\u1ea7u, \u0111au r\u0103ng, vi\u00eam d\u1ea1 d\u00e0y v\u00e0 s\u1ed1t b\u1edfi c\u00e1c nh\u00f3m thi\u1ec3u s\u1ed1 Yi, Zhuang v\u00e0 T\u00e2y T\u1ea1ng trong h\u00e0ng tr\u0103m n\u0103m (Medica, 1976; Wang et al. , 2012).<\/p>\n

S\u1ef1 ph\u00e1t tri\u1ec3n tr\u1ecb li\u1ec7u c\u1ee7a\u00a0E.<\/em><\/p>\n<\/section>\n<\/section>\n

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D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h2>\n

Scutellarin th\u1ec3 hi\u1ec7n c\u00e1c \u0111\u1eb7c t\u00ednh d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc b\u1ea5t th\u01b0\u1eddng \u1edf ng\u01b0\u1eddi v\u00e0 \u0111\u1ed9ng v\u1eadt. Gi\u1ed1ng nh\u01b0 nhi\u1ec1u glucuronide flavonoid c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb th\u1ef1c v\u1eadt, scutellarin c\u00f3 \u0111\u1ed9 h\u00f2a tan th\u1ea5p trong d\u1ecbch c\u01a1 th\u1ec3, sinh kh\u1ea3 d\u1ee5ng kh\u00f4ng thu\u1eadn l\u1ee3i v\u00e0 th\u1eddi gian b\u00e1n h\u1ee7y ng\u1eafn trong c\u01a1 th\u1ec3 \u0111\u1ed9ng v\u1eadt c\u00f3 v\u00fa. Sinh kh\u1ea3 d\u1ee5ng c\u1ee7a scutellarin \u0111\u1eb7c bi\u1ec7t th\u1ea5p, b\u1eb1ng ch\u1ee9ng l\u00e0 n\u1ed3ng \u0111\u1ed9 scutellarin trong huy\u1ebft t\u01b0\u01a1ng r\u1ea5t th\u1ea5p sau khi u\u1ed1ng m\u1ed9t li\u1ec1u. Trong m\u1ed9t nghi\u00ean c\u1ee9u tr\u00ean 20 t\u00ecnh nguy\u1ec7n vi\u00ean kh\u1ecfe m\u1ea1nh \u0111\u01b0\u1ee3c u\u1ed1ng li\u1ec1u scutellarin 60 mg, thu\u1ed1c g\u1ed1c c\u00f3 th\u1ec3<\/p>\n<\/section>\n<\/section>\n

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t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd<\/h2>\n

M\u1ed9t n\u1ed7 l\u1ef1c l\u1edbn \u0111\u00e3 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n \u0111\u1ec3 ghi l\u1ea1i v\u00e0 hi\u1ec3u r\u00f5 t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd c\u1ee7a scutellarin trong c\u00e1c h\u1ec7 th\u1ed1ng th\u00ed nghi\u1ec7m trong su\u1ed1t ba th\u1eadp k\u1ef7 qua. \u0110\u1eb7c bi\u1ec7t, m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y \u0111\u00e3 cung c\u1ea5p c\u00e1c ph\u00e9p \u0111o \u0111\u1ecbnh l\u01b0\u1ee3ng v\u1ec1 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb c\u1ee7a scutellarin v\u00e0 c\u00e1c thu\u1ed1c li\u00ean quan \u0111\u1ed1i v\u1edbi \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u n\u00e3o c\u1ee5c b\u1ed9, b\u1ec7nh tim m\u1ea1ch v\u00e0nh v\u00e0 bi\u1ebfn ch\u1ee9ng ti\u1ec3u \u0111\u01b0\u1eddng tr\u00ean m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt. D\u1eef li\u1ec7u th\u1ef1c nghi\u1ec7m c\u0169ng h\u1ed7 tr\u1ee3 t\u00e1c d\u1ee5ng c\u00f3 l\u1ee3i c\u1ee7a thu\u1ed1c trong \u0111i\u1ec1u tr\u1ecb m\u1ed9t s\u1ed1 b\u1ec7nh kh\u00e1c<\/p>\n<\/section>\n<\/section>\n

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C\u01a1 ch\u1ebf, con \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u v\u00e0 m\u1ee5c ti\u00eau ph\u00e2n t\u1eed<\/h2>\n

L\u00e0m s\u00e1ng t\u1ecf c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng v\u00e0 x\u00e1c \u0111\u1ecbnh con \u0111\u01b0\u1eddng nh\u1eafm m\u1ee5c ti\u00eau v\u00e0 c\u00e1c ph\u00e2n t\u1eed c\u1ee7a thu\u1ed1c th\u1ea3o d\u01b0\u1ee3c l\u00e0 c\u1ea7n thi\u1ebft v\u00e0 quan tr\u1ecdng \u0111\u1ec3 c\u1ea3i thi\u1ec7n c\u00f4ng d\u1ee5ng \u0111i\u1ec1u tr\u1ecb c\u1ee7a ch\u00fang. Tuy nhi\u00ean, nh\u1eefng k\u1ef3 v\u1ecdng \u0111\u00e1ng m\u01a1 \u01b0\u1edbc n\u00e0y v\u1eabn l\u00e0 m\u1ed9t th\u00e1ch th\u1ee9c l\u1edbn \u0111\u1ed1i v\u1edbi h\u1ea7u h\u1ebft c\u00e1c ph\u01b0\u01a1ng ph\u00e1p tr\u1ecb li\u1ec7u c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb th\u1ea3o d\u01b0\u1ee3c, b\u1ea5t ch\u1ea5p nh\u1eefng n\u1ed7 l\u1ef1c to l\u1edbn \u0111\u00e3 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n. M\u1ed9t ph\u1ea7n, \u0111i\u1ec1u n\u00e0y l\u00e0 do th\u1ef1c t\u1ebf l\u00e0 h\u1ea7u h\u1ebft c\u00e1c lo\u1ea1i thu\u1ed1c th\u1ea3o d\u01b0\u1ee3c \u0111\u1ec1u ph\u00e1t tri\u1ec3n th\u00f4ng qua kinh nghi\u1ec7m thay v\u00ec thi\u1ebft k\u1ebf thu\u1ed1c h\u1ee3p l\u00fd v\u00e0 \u0111\u00f4i khi d\u1ef1a tr\u00ean c\u00e1c kh\u00e1i ni\u1ec7m tr\u1eebu t\u01b0\u1ee3ng, ch\u1eb3ng h\u1ea1n nh\u01b0<\/p>\n<\/section>\n<\/section>\n

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\u0110\u1ed9c t\u00ednh<\/h2>\n

Scutellarin v\u00e0 breviscapine \u00edt \u0111\u1ed9c ho\u1eb7c kh\u00f4ng \u0111\u1ed9c \u1edf \u0111\u1ed9ng v\u1eadt. Ng\u01b0\u1eddi ta ph\u00e1t hi\u1ec7n ra r\u1eb1ng li\u1ec1u scutellarin dung n\u1ea1p t\u1ed1i \u0111a l\u00e0 >10 g\/kg \u1edf chu\u1ed9t v\u00e0 do \u0111\u00f3, li\u1ec1u g\u00e2y ch\u1ebft c\u1ea5p t\u00ednh c\u1ee7a n\u00f3 (LD50<\/sub>) kh\u00f4ng th\u1ec3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh b\u1eb1ng th\u1ef1c nghi\u1ec7m (Li et al., 2011). Trong m\u1ed9t nghi\u00ean c\u1ee9u b\u00e1n c\u1ea5p, d\u00f9ng scutellarin \u0111\u01b0\u1eddng u\u1ed1ng v\u1edbi li\u1ec1u 100 ho\u1eb7c 500 mg\/kg m\u1ed7i ng\u00e0y trong t\u1ed1i \u0111a 30 ng\u00e0y kh\u00f4ng g\u00e2y t\u1eed vong ho\u1eb7c thay \u0111\u1ed5i \u0111\u00e1ng k\u1ec3 v\u1ec1 huy\u1ebft h\u1ecdc, h\u00f3a h\u1ecdc m\u00e1u v\u00e0 ph\u00e2n t\u00edch n\u01b0\u1edbc ti\u1ec3u, ngo\u1ea1i tr\u1eeb vi\u1ec7c gi\u1ea3m kh\u00f4ng li\u00ean quan \u0111\u1ebfn li\u1ec1u.<\/p>\n<\/section>\n<\/section>\n

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Ch\u1ea5t mang h\u1ea1t nano v\u1edbi c\u00e1c d\u1eabn xu\u1ea5t l\u01b0\u1ee1ng t\u00ednh<\/h2>\n

Scutellarin \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 c\u00f3 hi\u1ec7u qu\u1ea3 trong \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng t\u1ebf b\u00e0o n\u1ed9i m\u00f4 m\u1ea1ch m\u00e1u do ti\u1ec3u \u0111\u01b0\u1eddng, nh\u01b0ng \u1ee9ng d\u1ee5ng l\u00e2m s\u00e0ng c\u1ee7a n\u00f3 b\u1ecb h\u1ea1n ch\u1ebf do sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng th\u1ea5p. M\u1ed9t ch\u1ea5t mang h\u1ea1t nano nh\u1eafm m\u1ee5c ti\u00eau v\u00e0o ru\u1ed9t m\u1edbi c\u00f3 d\u1eabn xu\u1ea5t chitosan l\u01b0\u1ee1ng t\u00ednh ch\u1ee9a scutellarin (Chit-DC-VB12-Scu) \u0111\u00e3 \u0111\u01b0\u1ee3c t\u1ea1o ra \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng sinh kh\u1ea3 d\u1ee5ng c\u1ee7a scutellarin v\u00ec t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb c\u1ee7a n\u00f3 trong b\u1ec7nh v\u00f5ng m\u1ea1c ti\u1ec3u \u0111\u01b0\u1eddng th\u1ef1c nghi\u1ec7m (Wang v\u00e0 c\u1ed9ng s\u1ef1, 2017). Nghi\u00ean c\u1ee9u sinh kh\u1ea3 d\u1ee5ng \u1edf chu\u1ed9t cho th\u1ea5y<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Ph\u1ea7n k\u1ebft lu\u1eadn<\/h2>\n

S\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c t\u00e1c nh\u00e2n tr\u1ecb li\u1ec7u t\u1eeb c\u00e1c lo\u1ea1i thu\u1ed1c th\u1ea3o d\u01b0\u1ee3c truy\u1ec1n th\u1ed1ng \u0111\u00e3 tr\u1edf th\u00e0nh m\u1ed9t h\u01b0\u1edbng \u0111i \u0111\u1ea7y h\u1ee9a h\u1eb9n trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb m\u1ed9t lo\u1ea1t b\u1ec7nh v\u00e0 t\u00ecnh tr\u1ea1ng b\u1ec7nh l\u00fd nh\u01b0 thi\u1ebfu m\u00e1u n\u00e3o v\u00e0 c\u01a1 tim, bi\u1ebfn ch\u1ee9ng ti\u1ec3u \u0111\u01b0\u1eddng, tho\u00e1i h\u00f3a th\u1ea7n kinh v\u00e0 ung th\u01b0. M\u1ed9t ph\u1ea7n, \u0111i\u1ec1u n\u00e0y l\u00e0 do s\u1ef1 ph\u00e1t tri\u1ec3n b\u1ec7nh l\u00fd c\u1ee7a nh\u1eefng c\u0103n b\u1ec7nh n\u00e0y r\u1ea5t ph\u1ee9c t\u1ea1p, li\u00ean quan \u0111\u1ebfn s\u1ef1 t\u01b0\u01a1ng t\u00e1c n\u0103ng \u0111\u1ed9ng gi\u1eefa nhi\u1ec1u ch\u1ee9c n\u0103ng v\u00e0 c\u1ea5u tr\u00fac ch\u01b0a \u0111\u01b0\u1ee3c hi\u1ec3u r\u00f5. S\u1ef1 ph\u1ee9c t\u1ea1p n\u00e0y th\u01b0\u1eddng v\u01b0\u1ee3t xa<\/p>\n<\/section>\n<\/section>\n

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Nh\u00ecn nh\u1eadn<\/h2>\n

Nghi\u00ean c\u1ee9u n\u00e0y \u0111\u01b0\u1ee3c h\u1ed7 tr\u1ee3 b\u1edfi c\u00e1c kho\u1ea3n t\u00e0i tr\u1ee3 sau \u0111\u00e2y cho LW: (a) 81660551 t\u1eeb\u00a0Qu\u1ef9 khoa h\u1ecdc t\u1ef1 nhi\u00ean qu\u1ed1c gia Trung Qu\u1ed1c<\/span>; (b) 2014FB151 t\u1eeb\u00a0D\u1ef1 \u00e1n nghi\u00ean c\u1ee9u c\u01a1 b\u1ea3n \u1ee9ng d\u1ee5ng V\u00e2n Nam<\/span>,\u00a0S\u1edf Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 t\u1ec9nh V\u00e2n Nam, Trung Qu\u1ed1c<\/span>; v\u00e0 (c) 2017FE467(-126) t\u1eeb D\u1ef1 \u00e1n Nghi\u00ean c\u1ee9u C\u01a1 b\u1ea3n \u1ee8ng d\u1ee5ng V\u00e2n Nam-Qu\u1ef9 li\u00ean minh<\/span>,\u00a0S\u1edf Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 t\u1ec9nh V\u00e2n Nam<\/span>\u00a0V\u00e0\u00a0\u0110\u1ea1i h\u1ecdc Y C\u00f4n Minh, Trung Qu\u1ed1c<\/span>; v\u00e0 m\u1ed9t kho\u1ea3n tr\u1ee3 c\u1ea5p cho QM: 7939050W t\u1eeb Vi\u1ec7n An to\u00e0n v\u00e0 Lao \u0111\u1ed9ng Qu\u1ed1c gia<\/p>\n<\/section>\n<\/section>\n

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Tuy\u00ean b\u1ed1 t\u1eeb ch\u1ed1i tr\u00e1ch nhi\u1ec7m<\/h2>\n

Nh\u1eefng ph\u00e1t hi\u1ec7n v\u00e0 k\u1ebft lu\u1eadn trong b\u00e1o c\u00e1o n\u00e0y l\u00e0 c\u1ee7a c\u00e1c t\u00e1c gi\u1ea3 v\u00e0 kh\u00f4ng nh\u1ea5t thi\u1ebft th\u1ec3 hi\u1ec7n quan \u0111i\u1ec3m c\u1ee7a Vi\u1ec7n Qu\u1ed1c gia v\u1ec1 An to\u00e0n v\u00e0 S\u1ee9c kh\u1ecfe ngh\u1ec1 nghi\u1ec7p.<\/p>\n<\/section>\n<\/section>\n

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Xung \u0111\u1ed9t v\u1ec1 tuy\u00ean b\u1ed1 l\u00e3i su\u1ea5t<\/h2>\n

C\u00e1c t\u00e1c gi\u1ea3 tuy\u00ean b\u1ed1 r\u1eb1ng kh\u00f4ng c\u00f3 xung \u0111\u1ed9t l\u1ee3i \u00edch.<\/p>\n<\/section>\n<\/section>\n<\/div>\n<\/div>\n

 <\/p>\n

 <\/p>\n

Ngu\u1ed3n<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Stroke and myocardial infarction are among the most common causes of mortality and disability in the world. The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation,<\/p>","protected":false},"author":1,"featured_media":5369,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9],"tags":[],"class_list":["post-5163","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-supplements"],"_links":{"self":[{"href":"https:\/\/directcm.com\/vi\/wp-json\/wp\/v2\/posts\/5163","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/directcm.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/directcm.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/directcm.com\/vi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/directcm.com\/vi\/wp-json\/wp\/v2\/comments?post=5163"}],"version-history":[{"count":1,"href":"https:\/\/directcm.com\/vi\/wp-json\/wp\/v2\/posts\/5163\/revisions"}],"predecessor-version":[{"id":5376,"href":"https:\/\/directcm.com\/vi\/wp-json\/wp\/v2\/posts\/5163\/revisions\/5376"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/directcm.com\/vi\/wp-json\/wp\/v2\/media\/5369"}],"wp:attachment":[{"href":"https:\/\/directcm.com\/vi\/wp-json\/wp\/v2\/media?parent=5163"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/directcm.com\/vi\/wp-json\/wp\/v2\/categories?post=5163"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/directcm.com\/vi\/wp-json\/wp\/v2\/tags?post=5163"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}