{"id":5171,"date":"2024-01-16T11:01:40","date_gmt":"2024-01-16T11:01:40","guid":{"rendered":"https:\/\/farlong.com\/?p=5171"},"modified":"2024-01-27T10:30:11","modified_gmt":"2024-01-27T10:30:11","slug":"research-progress-on-pyroptosis-mediated-immune-inflammatory-response-in-ischemic-stroke-and-the-role-of-natural-plant-components-as-regulator-of-pyroptosis-a-review","status":"publish","type":"post","link":"https:\/\/directcm.com\/vi\/research-progress-on-pyroptosis-mediated-immune-inflammatory-response-in-ischemic-stroke-and-the-role-of-natural-plant-components-as-regulator-of-pyroptosis-a-review\/","title":{"rendered":"Ti\u1ebfn b\u1ed9 nghi\u00ean c\u1ee9u v\u1ec1 ph\u1ea3n \u1ee9ng vi\u00eam mi\u1ec5n d\u1ecbch qua trung gian pyroptosis trong \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 v\u00e0 vai tr\u00f2 c\u1ee7a c\u00e1c th\u00e0nh ph\u1ea7n th\u1ef1c v\u1eadt t\u1ef1 nhi\u00ean trong vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh b\u1ec7nh pyroptosis: \u0110\u00e1nh gi\u00e1"},"content":{"rendered":"<div id=\"ab0015\" class=\"abstract author-highlights\">\n<h2 class=\"section-title u-h4 u-margin-l-top u-margin-xs-bottom\">\u0110i\u1ec3m n\u1ed5i b\u1eadt<\/h2>\n<div id=\"abs0015\">\n<ul>\n<li id=\"p0005\">T\u1ed5ng quan n\u00e0y t\u00f3m t\u1eaft c\u01a1 ch\u1ebf ph\u00e2n t\u1eed m\u1edbi nh\u1ea5t c\u1ee7a b\u1ec7nh pyroptosis tr\u00ean \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9.<\/li>\n<li id=\"p0010\">T\u1ed5ng quan n\u00e0y t\u00f3m t\u1eaft vai tr\u00f2 c\u1ee7a c\u00e1c th\u00e0nh ph\u1ea7n th\u1ef1c v\u1eadt t\u1ef1 nhi\u00ean trong vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh b\u1ec7nh pyroptosis trong \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9<\/li>\n<li id=\"p0015\">\u0110i\u1ec1u ch\u1ec9nh ch\u1ee9ng pyroptosis trong \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 \u0111\u01b0\u1ee3c \u0111\u1ec1 xu\u1ea5t nh\u01b0 m\u1ed9t chi\u1ebfn l\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb ti\u1ec1m n\u0103ng.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div id=\"ab0010\" class=\"abstract author\"><\/p>\n<h2><\/h2>\n<h2 class=\"section-title u-h4 u-margin-l-top u-margin-xs-bottom\">tr\u1eebu t\u01b0\u1ee3ng<\/h2>\n<div id=\"abs0010\">\n<p id=\"sp0030\"><a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/brain-ischemia\">\u0110\u1ed9t qu\u1ef5 thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9<\/a>\u00a0(IS) l\u00e0 m\u1ed9t trong nh\u1eefng nguy\u00ean nh\u00e2n h\u00e0ng \u0111\u1ea7u g\u00e2y t\u1eed vong v\u00e0 t\u00e0n t\u1eadt. C\u01a1 ch\u1ebf b\u1ec7nh sinh c\u1ee7a n\u00f3 kh\u00f4ng ho\u00e0n to\u00e0n r\u00f5 r\u00e0ng v\u00e0 d\u00f2ng vi\u00eam l\u00e0 m\u1ed9t trong nh\u1eefng nguy\u00ean nh\u00e2n ch\u00ednh c\u1ee7a n\u00f3.\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c qu\u00e1 tr\u00ecnh b\u1ec7nh l\u00fd t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathological-process\">qu\u00e1 tr\u00ecnh b\u1ec7nh l\u00fd<\/a>. Th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng hi\u1ec7n nay c\u1ee7a IS l\u00e0 kh\u00f4i ph\u1ee5c l\u1ea1i\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 ngu\u1ed3n cung c\u1ea5p m\u00e1u t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascularity\">cung c\u1ea5p m\u00e1u<\/a>\u00a0\u0111\u1ebfn v\u00f9ng thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 sau IS c\u00e0ng s\u1edbm c\u00e0ng t\u1ed1t th\u00f4ng qua\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 li\u1ec7u ph\u00e1p ti\u00eau huy\u1ebft kh\u1ed1i t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/fibrinolytic-therapy\">li\u1ec7u ph\u00e1p thrombolytic<\/a>\u00a0\u0111\u1ec3 b\u1ea3o v\u1ec7 s\u1ee9c s\u1ed1ng v\u00e0 ch\u1ee9c n\u0103ng c\u1ee7a t\u1ebf b\u00e0o th\u1ea7n kinh. Tuy nhi\u00ean, t\u00e1i t\u01b0\u1edbi m\u00e1u m\u00e1u c\u00e0ng l\u00e0m t\u0103ng th\u00eam t\u1ed5n th\u01b0\u01a1ng do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 v\u00e0 g\u00e2y ra t\u1ed5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9. Qu\u00e1 tr\u00ecnh b\u1ec7nh l\u00fd c\u1ee7a t\u1ed5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u do thi\u1ebfu m\u00e1u n\u00e3o c\u1ee5c b\u1ed9 li\u00ean quan \u0111\u1ebfn nhi\u1ec1u c\u01a1 ch\u1ebf v\u00e0 c\u01a1 ch\u1ebf ch\u00ednh x\u00e1c v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c l\u00e0m r\u00f5 ho\u00e0n to\u00e0n.\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Pyroptosis t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyroptosis\">b\u1ec7nh pyroptosis<\/a>, m\u1ed9t d\u1ea1ng vi\u00eam m\u1edbi \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 qu\u00e1 tr\u00ecnh ch\u1ebft t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c l\u1eadp tr\u00ecnh t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/programmed-cell-death\">ch\u1ebft t\u1ebf b\u00e0o theo ch\u01b0\u01a1ng tr\u00ecnh<\/a>, \u0111\u00f3ng m\u1ed9t vai tr\u00f2 quan tr\u1ecdng trong s\u1ef1 kh\u1edfi \u0111\u1ea7u v\u00e0 ti\u1ebfn tri\u1ec3n c\u1ee7a t\u00ecnh tr\u1ea1ng vi\u00eam. \u0110\u00f3 l\u00e0 m\u1ed9t c\u00e1i ch\u1ebft \u0111\u01b0\u1ee3c l\u1eadp tr\u00ecnh do vi\u00eam nhi\u1ec5m qua trung gian\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 caspase t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/caspase\">th\u00e1c n\u01b0\u1edbc<\/a>\u00a0Caspase-1\/4\/5\/11, c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn s\u01b0ng v\u00e0 v\u1ee1 t\u1ebf b\u00e0o, gi\u1ea3i ph\u00f3ng c\u00e1c y\u1ebfu t\u1ed1 g\u00e2y vi\u00eam IL-1\u03b2 v\u00e0 IL-18, \u0111\u1ed3ng th\u1eddi g\u00e2y ra m\u1ed9t \u0111\u1ee3t vi\u00eam. C\u00e1c nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng pyroptosis v\u00e0 ph\u1ea3n \u1ee9ng vi\u00eam qua trung gian c\u1ee7a n\u00f3 l\u00e0 nh\u1eefng y\u1ebfu t\u1ed1 quan tr\u1ecdng l\u00e0m n\u1eb7ng th\u00eam t\u1ed5n th\u01b0\u01a1ng n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 v\u00e0 vi\u1ec7c \u1ee9c ch\u1ebf pyroptosis c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m t\u1ed5n th\u01b0\u01a1ng n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9. H\u01a1n n\u1eefa, c\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng c\u00e1c th\u00e0nh ph\u1ea7n th\u1ef1c v\u1eadt t\u1ef1 nhi\u00ean c\u00f3 th\u1ec3 c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u ch\u1ec9nh b\u1ec7nh pyroptosis. Do \u0111\u00f3, b\u00e0i t\u1ed5ng quan n\u00e0y kh\u00f4ng ch\u1ec9 t\u00f3m t\u1eaft c\u01a1 ch\u1ebf ph\u00e2n t\u1eed c\u1ee7a b\u1ec7nh pyroptosis v\u00e0 vai tr\u00f2 c\u1ee7a n\u00f3 trong \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 m\u00e0 c\u00f2n t\u00f3m t\u1eaft vai tr\u00f2 c\u1ee7a c\u00e1c th\u00e0nh ph\u1ea7n th\u1ef1c v\u1eadt t\u1ef1 nhi\u00ean trong vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh b\u1ec7nh pyroptosis, nh\u1eb1m cung c\u1ea5p th\u00f4ng tin tham kh\u1ea3o v\u1ec1 b\u1ec7nh pyroptosis cho b\u1ec7nh nh\u00e2n.\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1ch \u0111i\u1ec1u tr\u1ecb t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/therapeutic-procedure\">s\u1ef1 \u0111\u1ed1i \u0111\u00e3i<\/a>\u00a0c\u1ee7a IS trong t\u01b0\u01a1ng lai.<\/p>\n<div class=\"Keywords u-font-serif text-s\">\n<div id=\"keys0005\" class=\"keywords-section\">\n<h2 class=\"section-title u-h4 u-margin-l-top u-margin-xs-bottom\">T\u1eeb kh\u00f3a<\/h2>\n<div id=\"key0005\" class=\"keyword\">b\u1ec7nh s\u1ed1t r\u00e9t; \u0110\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9; Caspase; Th\u00e0nh ph\u1ea7n th\u1ef1c v\u1eadt t\u1ef1 nhi\u00ean; g\u00e2y s\u1ed1t<\/div>\n<\/div>\n<\/div>\n<div id=\"body\" class=\"Body u-font-serif text-s\">\n<div>\n<section id=\"sec0005\">\n<h2 id=\"sect0025\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">1. Gi\u1edbi thi\u1ec7u<\/h2>\n<p id=\"p0025\">V\u1edbi s\u1ef1 gi\u00e0 \u0111i c\u1ee7a d\u00e2n s\u1ed1 th\u1ebf gi\u1edbi, t\u1ef7 l\u1ec7 m\u1eafc b\u1ec7nh\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 b\u1ec7nh m\u1ea1ch m\u00e1u n\u00e3o t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebrovascular-disease\">b\u1ec7nh m\u1ea1ch m\u00e1u n\u00e3o<\/a>\u00a0(ch\u1eb3ng h\u1ea1n nh\u01b0 \u0111\u1ed9t qu\u1ef5) \u0111\u00e3 tr\u1edf th\u00e0nh b\u1ec7nh l\u1edbn th\u1ee9 hai tr\u00ean th\u1ebf gi\u1edbi v\u00e0 m\u1ed1i \u0111e d\u1ecda \u0111\u1ed1i v\u1edbi con ng\u01b0\u1eddi ng\u00e0y c\u00e0ng gia t\u0103ng\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib1\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib1\"><span class=\"anchor-text\">[1]<\/span><\/a>. \u0110\u1ed9t qu\u1ef5 bao g\u1ed3m\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/brain-ischemia\">\u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9<\/a>\u00a0(L\u00e0 v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 \u0111\u1ed9t qu\u1ef5 do xu\u1ea5t huy\u1ebft t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebral-hemorrhage\">\u0111\u1ed9t qu\u1ef5 xu\u1ea5t huy\u1ebft<\/a>v\u00e0 c\u00f3 t\u1edbi 87% \u0111\u1ed9t qu\u1ef5 l\u00e0 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib2\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib2\"><span class=\"anchor-text\">[2]<\/span><\/a>. IS l\u00e0 m\u1ed9t c\u1ea5p c\u1ee9u l\u00e2m s\u00e0ng ph\u1ed5 bi\u1ebfn v\u00e0 t\u1ef7 l\u1ec7 m\u1eafc b\u1ec7nh n\u00e0y \u0111ang t\u0103ng l\u00ean h\u00e0ng n\u0103m. Th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng hi\u1ec7n nay c\u1ee7a IS l\u00e0 kh\u00f4i ph\u1ee5c l\u1ea1i\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 ngu\u1ed3n cung c\u1ea5p m\u00e1u t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascularity\">cung c\u1ea5p m\u00e1u<\/a>\u00a0\u0111\u1ebfn v\u00f9ng thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 sau IS c\u00e0ng s\u1edbm c\u00e0ng t\u1ed1t th\u00f4ng qua\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 li\u1ec7u ph\u00e1p ti\u00eau huy\u1ebft kh\u1ed1i t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/fibrinolytic-therapy\">li\u1ec7u ph\u00e1p thrombolytic<\/a>\u00a0\u0111\u1ec3 b\u1ea3o v\u1ec7 s\u1ee9c s\u1ed1ng v\u00e0 ch\u1ee9c n\u0103ng c\u1ee7a t\u1ebf b\u00e0o th\u1ea7n kinh\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib3\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib3\"><span class=\"anchor-text\">[3]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib4\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib4\"><span class=\"anchor-text\">[4]<\/span><\/a>. Tuy nhi\u00ean, t\u1ed5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 (IRI) sau khi ph\u1ee5c h\u1ed3i l\u01b0u l\u01b0\u1ee3ng m\u00e1u th\u01b0\u1eddng g\u00e2y ra t\u1ed5n th\u01b0\u01a1ng nghi\u00eam tr\u1ecdng h\u01a1n cho c\u01a1 th\u1ec3.\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 m\u00f4 n\u00e3o t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-tissue\">m\u00f4 n\u00e3o<\/a>\u00a0v\u00e0 t\u1ebf b\u00e0o th\u1ea7n kinh, \u0111i\u1ec1u n\u00e0y c\u00e0ng tr\u1edf th\u00e0nh y\u1ebfu t\u1ed1 quan tr\u1ecdng d\u1eabn \u0111\u1ebfn ti\u00ean l\u01b0\u1ee3ng x\u1ea5u v\u00e0 r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng c\u1ee7a b\u1ec7nh nh\u00e2n.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib5\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib5\"><span class=\"anchor-text\">[5]<\/span><\/a>. Cu\u1ed9c kh\u1ea3o s\u00e1t d\u1ecbch t\u1ec5 h\u1ecdc tr\u00ean to\u00e0n th\u1ebf gi\u1edbi \u0111\u00e3 ph\u00e2n t\u00edch d\u1eef li\u1ec7u t\u1eeb n\u0103m 1990 \u0111\u1ebfn n\u0103m 2019 t\u1ea1i 204 qu\u1ed1c gia v\u00e0 khu v\u1ef1c tr\u00ean th\u1ebf gi\u1edbi. B\u00e1o c\u00e1o c\u1ee7a h\u1ecd cho bi\u1ebft \u0111\u1ed9t qu\u1ef5 v\u1eabn l\u00e0 nguy\u00ean nh\u00e2n g\u00e2y t\u1eed vong \u0111\u1ee9ng th\u1ee9 hai (11,6% trong t\u1ed5ng s\u1ed1 ca t\u1eed vong) v\u00e0 l\u00e0 nguy\u00ean nh\u00e2n \u0111\u1ee9ng th\u1ee9 ba g\u00e2y t\u1eed vong v\u00e0 t\u00e0n t\u1eadt [5,7% trong t\u1ed5ng s\u1ed1\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 s\u1ed1 n\u0103m s\u1ed1ng \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh theo t\u00ecnh tr\u1ea1ng khuy\u1ebft t\u1eadt t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/disability-adjusted-life-years\">Khi\u1ebfm khuy\u1ebft \u0111i\u1ec1u ch\u1ec9nh nh\u1eefng n\u0103m trong \u0111\u1eddi<\/a>\u00a0(DALYs)], ch\u1ec9 \u0111\u1ee9ng sau\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 b\u1ec7nh s\u01a1 sinh t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/newborn-disease\">b\u1ec7nh s\u01a1 sinh<\/a>\u00a0(7,3% DALY) v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 b\u1ec7nh tim thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemic-heart-disease\">b\u1ec7nh tim thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9<\/a>\u00a0(7,2% DALYs) v\u00e0 s\u1ed1 l\u01b0\u1ee3ng b\u1ec7nh nh\u00e2n \u0111\u1ed9t qu\u1ef5 v\u1eabn ng\u00e0y c\u00e0ng gia t\u0103ng\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib6\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib6\"><span class=\"anchor-text\">[6]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib7\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib7\"><span class=\"anchor-text\">[7]<\/span><\/a>, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u1edf Trung Qu\u1ed1c. Trung Qu\u1ed1c \u0111\u00e3 tr\u1edf th\u00e0nh qu\u1ed1c gia c\u00f3 nguy c\u01a1 \u0111\u1ed9t qu\u1ef5 cao nh\u1ea5t th\u1ebf gi\u1edbi, v\u1edbi nguy c\u01a1 \u0111\u1ed9t qu\u1ef5 \u1edf ng\u01b0\u1eddi d\u00e2n l\u00ean t\u1edbi 39,3%, nguy c\u01a1 \u0111\u1ed9t qu\u1ef5 \u1edf nam gi\u1edbi Trung Qu\u1ed1c c\u0169ng cao nh\u1ea5t th\u1ebf gi\u1edbi, v\u01b0\u1ee3t qu\u00e1 41%; IS \u0111\u00e3 t\u0103ng t\u1eeb nguy\u00ean nh\u00e2n g\u00e2y t\u1eed vong \u0111\u1ee9ng th\u1ee9 ba (t\u00ednh \u0111\u1ebfn n\u0103m 1990) l\u00ean nguy\u00ean nh\u00e2n g\u00e2y t\u1eed vong \u0111\u1ea7u ti\u00ean (t\u00ednh \u0111\u1ebfn n\u0103m 2017) \u0111\u1ed1i v\u1edbi ng\u01b0\u1eddi d\u00e2n Trung Qu\u1ed1c\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib8\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib8\"><span class=\"anchor-text\">[8]<\/span><\/a>. C\u00e1c nghi\u00ean c\u1ee9u hi\u1ec7n nay cho th\u1ea5y c\u01a1 ch\u1ebf b\u1ec7nh l\u00fd c\u1ee7a IRI n\u00e3o (CIRI) ch\u1ee7 y\u1ebfu l\u00e0 do\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 stress oxy h\u00f3a t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/oxidative-stress\">c\u0103ng th\u1eb3ng oxy h\u00f3a<\/a>\u00a0ch\u1ea5n th\u01b0\u01a1ng,\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 t\u1ed5n th\u01b0\u01a1ng do vi\u00eam t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammatory-injury\">ch\u1ea5n th\u01b0\u01a1ng vi\u00eam<\/a>, t\u1ed5n th\u01b0\u01a1ng ty th\u1ec3, b\u1ec7nh t\u1ef1 th\u1ef1c, v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 qu\u00e1 tr\u00ecnh apoptosis t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/programmed-cell-death\">s\u1ef1 ch\u1ebft t\u1ebf b\u00e0o<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib9\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib9\"><span class=\"anchor-text\">[9]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib10\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib10\"><span class=\"anchor-text\">[10]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib11\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib11\"><span class=\"anchor-text\">[11]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib12\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib12\"><span class=\"anchor-text\">[12]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib13\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib13\"><span class=\"anchor-text\">[13]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib14\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib14\"><span class=\"anchor-text\">[14]<\/span><\/a>. Tuy nhi\u00ean, nh\u1eefng \u0111i\u1ec1u n\u00e0y v\u1eabn ch\u01b0a \u0111\u1ee7 \u0111\u1ec3 gi\u1ea3i th\u00edch c\u01a1 ch\u1ebf b\u1ec7nh l\u00fd c\u1ee7a\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 CIRI t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunoreactive-insulin\">CIRI<\/a>. V\u00ed d\u1ee5, c\u00e1i ch\u1ebft c\u1ee7a t\u1ebf b\u00e0o th\u1ea7n kinh sau CIRI \u0111\u01b0\u1ee3c cho l\u00e0 ch\u1ee7 y\u1ebfu do apoptosis g\u00e2y ra v\u00e0 h\u01b0\u1edbng b\u1ea3o v\u1ec7 t\u1ebf b\u00e0o th\u1ea7n kinh ch\u1ee7 y\u1ebfu l\u00e0 ch\u1ed1ng apoptosis. Tuy nhi\u00ean, apoptosis kh\u00f4ng li\u00ean quan tr\u1ef1c ti\u1ebfp \u0111\u1ebfn t\u00ecnh tr\u1ea1ng vi\u00eam\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib15\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib15\"><span class=\"anchor-text\">[15]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib16\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib16\"><span class=\"anchor-text\">[16]<\/span><\/a>, nh\u01b0ng c\u00f3 m\u1ed9t l\u01b0\u1ee3ng \u0111\u00e1ng k\u1ec3 ph\u1ea3n \u1ee9ng vi\u00eam trong CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib16\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib16\"><span class=\"anchor-text\">[16]<\/span><\/a>. V\u00ec v\u1eady, c\u1ea7n l\u00e0m r\u00f5 h\u01a1n n\u1eefa c\u01a1 ch\u1ebf sinh l\u00fd b\u1ec7nh c\u1ee7a IS v\u00e0 t\u00ecm hi\u1ec3u th\u00eam v\u1ec1 nguy\u00ean nh\u00e2n c\u1ee7a CIRI.<\/p>\n<p id=\"p0030\"><a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Pyroptosis t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyroptosis\">b\u1ec7nh pyroptosis<\/a>, c\u00f2n \u0111\u01b0\u1ee3c bi\u1ebft l\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 t\u00ecnh tr\u1ea1ng vi\u00eam t\u1ebf b\u00e0o t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammatory-cell\">vi\u00eam t\u1ebf b\u00e0o<\/a>\u00a0ho\u1ea1i t\u1eed, l\u00e0 hi\u1ec7n t\u01b0\u1ee3ng t\u1ebf b\u00e0o ch\u1ebft theo ch\u01b0\u01a1ng tr\u00ecnh m\u1edbi \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n v\u00e0 x\u00e1c nh\u1eadn trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib17\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib17\"><span class=\"anchor-text\">[17]<\/span><\/a>. B\u1ec7nh pyroptosis ph\u1ee5 thu\u1ed9c v\u00e0o t\u00ecnh tr\u1ea1ng vi\u00eam\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 th\u00e1c t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/caspase\">th\u00e1c n\u01b0\u1edbc<\/a>\u00a0(ch\u1ee7 y\u1ebfu l\u00e0 caspase-1, 4, 5, 11) v\u00e0 k\u00e8m theo \u0111\u00f3 l\u00e0 gi\u1ea3i ph\u00f3ng m\u1ed9t s\u1ed1 l\u01b0\u1ee3ng l\u1edbn c\u00e1c y\u1ebfu t\u1ed1 g\u00e2y vi\u00eam. N\u00f3 \u0111\u01b0\u1ee3c bi\u1ec3u hi\u1ec7n b\u1eb1ng s\u1ef1 m\u1edf r\u1ed9ng li\u00ean t\u1ee5c c\u1ee7a t\u1ebf b\u00e0o cho \u0111\u1ebfn khi t\u1ebf b\u00e0o\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 hi\u1ec7n t\u01b0\u1ee3ng v\u1ee1 m\u00e0ng t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/membrane-rupture\">v\u1ee1 m\u00e0ng<\/a>, d\u1eabn \u0111\u1ebfn vi\u1ec7c gi\u1ea3i ph\u00f3ng c\u00e1c ch\u1ea5t trong t\u1ebf b\u00e0o v\u00e0 k\u00edch ho\u1ea1t ph\u1ea3n \u1ee9ng vi\u00eam m\u1ea1nh m\u1ebd\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib17\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib17\"><span class=\"anchor-text\">[17]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib18\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib18\"><span class=\"anchor-text\">[18]<\/span><\/a>. C\u00e1c\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c \u0111\u1eb7c \u0111i\u1ec3m h\u00ecnh th\u00e1i t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/morphological-trait\">\u0111\u1eb7c \u0111i\u1ec3m h\u00ecnh th\u00e1i<\/a>, c\u01a1 ch\u1ebf xu\u1ea5t hi\u1ec7n v\u00e0 \u0111i\u1ec1u h\u00f2a c\u1ee7a b\u1ec7nh pyroptosis kh\u00e1c v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p ch\u1ebft t\u1ebf b\u00e0o kh\u00e1c nh\u01b0 apoptosis v\u00e0 ho\u1ea1i t\u1eed\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib18\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib18\"><span class=\"anchor-text\">[18]<\/span><\/a>. B\u1ec7nh pyroptosis c\u00f3 li\u00ean quan r\u1ed9ng r\u00e3i \u0111\u1ebfn s\u1ef1 xu\u1ea5t hi\u1ec7n v\u00e0 ph\u00e1t tri\u1ec3n c\u1ee7a nhi\u1ec1u b\u1ec7nh kh\u00e1c nhau nh\u01b0 b\u1ec7nh truy\u1ec1n nhi\u1ec5m, b\u1ec7nh li\u00ean quan \u0111\u1ebfn h\u1ec7 th\u1ea7n kinh, b\u1ec7nh x\u01a1 v\u1eefa \u0111\u1ed9ng m\u1ea1ch v\u00e0 kh\u1ed1i u \u00e1c t\u00ednh\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib19\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib19\"><span class=\"anchor-text\">[19]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib20\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib20\"><span class=\"anchor-text\">[20]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib21\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib21\"><span class=\"anchor-text\">[21]<\/span><\/a>. C\u00e1c nghi\u00ean c\u1ee9u m\u1edbi nh\u1ea5t cho th\u1ea5y b\u1ec7nh pyroptosis v\u00e0 ph\u1ea3n \u1ee9ng vi\u00eam qua trung gian c\u1ee7a n\u00f3 c\u00f3 li\u00ean quan \u0111\u1ebfn\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 qu\u00e1 tr\u00ecnh b\u1ec7nh l\u00fd t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathological-process\">qu\u00e1 tr\u00ecnh b\u1ec7nh l\u00fd<\/a>\u00a0c\u1ee7a IS v\u00e0 vi\u1ec7c ng\u0103n ch\u1eb7n s\u1ef1 k\u00edch ho\u1ea1t c\u1ee7a b\u1ec7nh pyroptosis c\u00f3 l\u1ee3i cho vi\u1ec7c \u1ee9c ch\u1ebf d\u00f2ng vi\u00eam v\u00e0 gi\u1ea3m t\u1ed5n th\u01b0\u01a1ng n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib22\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib22\"><span class=\"anchor-text\">[22]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib23\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib23\"><span class=\"anchor-text\">[23]<\/span><\/a>. D\u1ef1a tr\u00ean \u0111i\u1ec1u n\u00e0y, vi\u1ec7c nghi\u00ean c\u1ee9u b\u1ec7nh pyroptosis l\u00e0 r\u1ea5t quan tr\u1ecdng \u0111\u1ed1i v\u1edbi\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1ch \u0111i\u1ec1u tr\u1ecb t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/therapeutic-procedure\">s\u1ef1 \u0111\u1ed1i \u0111\u00e3i<\/a>\u00a0c\u1ee7a IS; \u0111i\u1ec1u ch\u1ec9nh b\u1ec7nh pyroptosis c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m t\u1ef7 l\u1ec7 t\u1eed vong c\u1ee7a IS, c\u1ea3i thi\u1ec7n t\u1ef7 l\u1ec7 s\u1ed1ng s\u00f3t c\u1ee7a t\u1ebf b\u00e0o th\u1ea7n kinh v\u00e0 c\u1ea3i thi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh nh\u00e2n IS. Hi\u1ec7n nay,\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 thu\u1ed1c t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chemotherapeutic-agent\">thu\u1ed1c<\/a>\u00a0n\u1ed7 l\u1ef1c \u0111\u00f3\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 ch\u1ea5t b\u1ea3o v\u1ec7 th\u1ea7n kinh t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroprotective-agent\">b\u1ea3o v\u1ec7 th\u1ea7n kinh<\/a>\u00a0t\u00e1c \u0111\u1ed9ng b\u1eb1ng c\u00e1ch \u0111i\u1ec1u ch\u1ec9nh con \u0111\u01b0\u1eddng pyroptosis \u0111ang \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n. \u0110\u1eb7c bi\u1ec7t, c\u00f3 nhi\u1ec1u nghi\u00ean c\u1ee9u v\u1ec1 c\u00e1c th\u00e0nh ph\u1ea7n th\u1ef1c v\u1eadt t\u1ef1 nhi\u00ean \u0111i\u1ec1u h\u00f2a qu\u00e1 tr\u00ecnh pyroptosis c\u1ee7a c\u00e1c \u0111\u01a1n v\u1ecb t\u1ebf b\u00e0o th\u1ea7n kinh m\u1ea1ch m\u00e1u trong IS. C\u00e1c nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e2y c\u1ee7a ch\u00fang t\u00f4i c\u0169ng cho th\u1ea5y\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 saponin t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/saponin\">saponin<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib24\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib24\"><span class=\"anchor-text\">[24]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib25\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib25\"><span class=\"anchor-text\">[25]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib26\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib26\"><span class=\"anchor-text\">[26]<\/span><\/a>\u00a0v\u00e0 c\u00e1c h\u1ee3p ch\u1ea5t \u0111a th\u00e0nh ph\u1ea7n\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib27\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib27\"><span class=\"anchor-text\">[27]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib28\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib28\"><span class=\"anchor-text\">[28]<\/span><\/a>\u00a0c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 quy tr\u00ecnh sinh h\u1ecdc t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/biological-phenomena-and-functions-concerning-the-entire-organism\">Qu\u00e1 tr\u00ecnh sinh h\u1ecdc<\/a>\u00a0b\u1ec7nh pyroptosis \u1edf IS. Do \u0111\u00f3, b\u00e0i t\u1ed5ng quan n\u00e0y kh\u00f4ng ch\u1ec9 t\u00f3m t\u1eaft c\u01a1 ch\u1ebf ph\u00e2n t\u1eed c\u1ee7a b\u1ec7nh pyroptosis v\u00e0 vai tr\u00f2 c\u1ee7a n\u00f3 trong \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 m\u00e0 c\u00f2n t\u00f3m t\u1eaft vai tr\u00f2 c\u1ee7a c\u00e1c th\u00e0nh ph\u1ea7n th\u1ef1c v\u1eadt t\u1ef1 nhi\u00ean trong vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh b\u1ec7nh pyroptosis \u0111\u1ec3 cung c\u1ea5p c\u00e1c h\u1ee3p ch\u1ea5t ch\u00ec ho\u1eb7c c\u00e1c th\u00e0nh ph\u1ea7n th\u1ef1c v\u1eadt t\u1ef1 nhi\u00ean cho s\u1ef1 ph\u00e1t tri\u1ec3n thu\u1ed1c li\u00ean quan \u0111\u1ebfn b\u1ec7nh pyroptosis trong t\u01b0\u01a1ng lai.<\/p>\n<\/section>\n<section id=\"sec0010\">\n<h2 id=\"sect0030\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">2. B\u1ec7nh pyroptosis<\/h2>\n<section id=\"sec0015\">\n<h3 id=\"sect0035\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.1. \u0110\u1eb7c \u0111i\u1ec3m c\u1ee7a b\u1ec7nh pyroptosis<\/h3>\n<div>\n<p id=\"p0035\"><a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Pyroptosis t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyroptosis\">b\u1ec7nh pyroptosis<\/a>\u00a0l\u00e0 m\u1ed9t d\u1ea1ng c\u1ee7a\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 qu\u00e1 tr\u00ecnh ch\u1ebft t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c l\u1eadp tr\u00ecnh t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/programmed-cell-death\">ch\u1ebft t\u1ebf b\u00e0o theo ch\u01b0\u01a1ng tr\u00ecnh<\/a>\u00a0ph\u1ee5 thu\u1ed9c v\u00e0o ch\u1ea5t g\u00e2y vi\u00eam\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 th\u00e1c t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/caspase\">th\u00e1c n\u01b0\u1edbc<\/a>, \u0111\u01b0\u1ee3c \u0111\u1eb7c tr\u01b0ng b\u1edfi s\u1ef1 h\u00ecnh th\u00e0nh c\u00e1c l\u1ed7 xuy\u00ean m\u00e0ng, s\u01b0ng t\u1ea5y v\u00e0 v\u1ee1 m\u00e0ng t\u1ebf b\u00e0o v\u00e0 gi\u1ea3i ph\u00f3ng c\u00e1c ch\u1ea5t g\u00e2y vi\u00eam\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib29\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib29\"><span class=\"anchor-text\">[29]<\/span><\/a>. Trong qu\u00e1 tr\u00ecnh apoptosis, c\u00e1c t\u1ebf b\u00e0o c\u00f3 s\u1ef1 ph\u00e2n m\u1ea3nh h\u1ea1t nh\u00e2n v\u00e0 t\u00ednh to\u00e0n v\u1eb9n c\u1ee7a m\u00e0ng t\u1ebf b\u00e0o, kh\u00f4ng g\u00e2y ra ph\u1ea3n \u1ee9ng vi\u00eam \u1edf c\u00e1c m\u00f4 xung quanh, trong khi c\u00e1c t\u1ebf b\u00e0o trong qu\u00e1 tr\u00ecnh pyroptosis c\u00f3 h\u00ecnh th\u00e1i h\u1ea1t nh\u00e2n v\u00e0 t\u1ebf b\u00e0o ho\u00e0n ch\u1ec9nh.\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 hi\u1ec7n t\u01b0\u1ee3ng v\u1ee1 m\u00e0ng t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/membrane-rupture\">v\u1ee1 m\u00e0ng<\/a>, g\u00e2y vi\u00eam ngo\u1ea1i bi\u00ean\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib30\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib30\"><span class=\"anchor-text\">[30]<\/span><\/a>. Khi pyroptosis x\u1ea3y ra, m\u00e0ng t\u1ebf b\u00e0o s\u1ebd d\u1ea7n d\u1ea7n v\u1ee1 ra \u0111\u1ec3 h\u00ecnh th\u00e0nh c\u00e1c l\u1ed7 m\u00e0ng t\u1ebf b\u00e0o 1\u20132nm, sau \u0111\u00f3 c\u00e1c n\u1ed9i dung trong t\u1ebf b\u00e0o nh\u01b0 c\u00e1c y\u1ebfu t\u1ed1 g\u00e2y vi\u00eam n\u1ed9i b\u00e0o v\u00e0 c\u00e1c ch\u1ea5t kh\u00e1c s\u1ebd \u0111\u01b0\u1ee3c gi\u1ea3i ph\u00f3ng ra b\u00ean ngo\u00e0i m\u00e0ng t\u1ebf b\u00e0o. Thu\u1ed1c nhu\u1ed9m xuy\u00ean m\u00e0ng nh\u01b0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 ethidium bromide t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ethidium-bromide\">ethidium bromide<\/a>\u00a0c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 quan s\u00e1t xem c\u00e1c t\u1ebf b\u00e0o c\u00f3 tr\u1ea3i qua qu\u00e1 tr\u00ecnh pyroptosis hay kh\u00f4ng\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib31\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib31\"><span class=\"anchor-text\">[31]<\/span><\/a>. Ngo\u00e0i ra, s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a ho\u1ea1i t\u1eed c\u00f2n ph\u1ee5 thu\u1ed9c v\u00e0o chu\u1ed7i h\u1ed7n h\u1ee3p protein kinase gi\u1ed1ng\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 protein mi\u1ec1n t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/protein-domain\">protein mi\u1ec1n<\/a>\u00a0(MLKL), c\u00f3 t\u00ednh ch\u1ecdn l\u1ecdc \u0111\u1ed1i v\u1edbi c\u00e1c ion \u0111i v\u00e0o t\u1ebf b\u00e0o v\u00e0 ch\u1ea5t nhi\u1ec5m s\u1eafc h\u1ea1t nh\u00e2n \u1edf d\u1ea1ng k\u1ebft b\u00f4ng ho\u1eb7c v\u00f3n c\u1ee5c \u1edf c\u1ea1nh. B\u1ec7nh pyroptosis ph\u1ee5 thu\u1ed9c v\u00e0o protein h\u00ecnh th\u00e0nh l\u1ed7 ch\u00e2n l\u00f4ng GSDMD, m\u1ed9t lo\u1ea1i protein kh\u00f4ng ch\u1ecdn l\u1ecdc g\u00e2y ra hi\u1ec7n t\u01b0\u1ee3ng h\u1ea1t nh\u00e2n\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 b\u1ec7nh pyknosis t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyknosis\">b\u1ec7nh pyknosis<\/a>\u00a0V\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 s\u1ef1 ph\u00e2n m\u1ea3nh DNA t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/dna-fragmentation\">s\u1ef1 ph\u00e2n m\u1ea3nh DNA<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib32\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib32\"><span class=\"anchor-text\">[32]<\/span><\/a>. C\u00f3 nh\u1eefng \u0111i\u1ec3m t\u01b0\u01a1ng \u0111\u1ed3ng v\u00e0 kh\u00e1c bi\u1ec7t gi\u1eefa pyroptosis, apoptosis, ho\u1ea1i t\u1eed v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 b\u1ec7nh ferroptosis t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ferroptosis\">b\u1ec7nh s\u1eaft t\u1eeb<\/a>, ch\u1eb3ng h\u1ea1n nh\u01b0 nguy\u00ean nh\u00e2n, thay \u0111\u1ed5i t\u1ebf b\u00e0o, v.v. Chi ti\u1ebft \u0111\u01b0\u1ee3c hi\u1ec3n th\u1ecb trong\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#tbl0005\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"tbl0005\"><span class=\"anchor-text\">B\u1ea3ng 1<\/span><\/a>.<\/p>\n<div id=\"tbl0005\" class=\"tables colsep-0 rowsep-0 frame-topbot\">\n<p id=\"sp0020\"><span class=\"label\">B\u1ea3ng 1<\/span>. \u0110i\u1ec3m t\u01b0\u01a1ng \u0111\u1ed3ng v\u00e0 kh\u00e1c bi\u1ec7t gi\u1eefa b\u1ec7nh pyroptosis, apoptosis v\u00e0 ho\u1ea1i t\u1eed.<\/p>\n<div class=\"groups\">\n<table>\n<thead>\n<tr class=\"rowsep-1\">\n<th scope=\"col\">\u0110\u1eb7c tr\u01b0ng<\/th>\n<th scope=\"col\">Th\u00e0nh ph\u1ea7n ch\u1eef k\u00fd<\/th>\n<th scope=\"col\">Nh\u1eefng thay \u0111\u1ed5i trong t\u1ebf b\u00e0o<\/th>\n<th scope=\"col\">Nguy\u00ean nh\u00e2n chung<\/th>\n<th scope=\"col\">ch\u1ea5t \u1ee9c ch\u1ebf<\/th>\n<th scope=\"col\">Th\u1ea9m quy\u1ec1n gi\u1ea3i quy\u1ebft<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<th scope=\"row\">b\u1ec7nh pyroptosis<\/th>\n<td>Pyroptosome, vi\u00eam<\/td>\n<td>H\u00ecnh th\u00e0nh l\u1ed7 ch\u00e2n l\u00f4ng, s\u01b0ng t\u1ebf b\u00e0o, v\u1ee1 m\u00e0ng sinh ch\u1ea5t, ng\u01b0ng t\u1ee5 ch\u1ea5t nhi\u1ec5m s\u1eafc, ph\u00e2n m\u1ea3nh DNA nh\u01b0ng c\u00f2n nguy\u00ean v\u1eb9n h\u1ea1t nh\u00e2n, v.v.<\/td>\n<td>DAMP, PAMP, nhi\u1ec5m tr\u00f9ng<\/td>\n<td>Thu\u1ed1c \u1ee9c ch\u1ebf GSDMD<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib19\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib19\"><span class=\"anchor-text\">[19]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib33\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib33\"><span class=\"anchor-text\">[33]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib34\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib34\"><span class=\"anchor-text\">[34]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib35\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib35\"><span class=\"anchor-text\">[35]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib36\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib36\"><span class=\"anchor-text\">[36]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">S\u1ef1 ch\u1ebft t\u1ebf b\u00e0o<\/th>\n<td>Apoptosome<\/td>\n<td>T\u1ebf b\u00e0o co l\u1ea1i v\u1edbi m\u00e0ng nguy\u00ean v\u1eb9n, m\u00e0ng sinh ch\u1ea5t ch\u1ea3y m\u00e1u, ng\u01b0ng t\u1ee5 ch\u1ea5t nhi\u1ec5m s\u1eafc, ph\u00e2n m\u1ea3nh DNA, v.v.<\/td>\n<td>Gen \u0111i\u1ec1u h\u00f2a c\u00e1c tr\u1ea1ng th\u00e1i sinh l\u00fd<\/td>\n<td>\u0110i\u1ec1u ch\u1ec9nh h\u1ecd caspase, h\u1ecd Bcl-2, p53, v.v.<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib37\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib37\"><span class=\"anchor-text\">[37]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib38\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib38\"><span class=\"anchor-text\">[38]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib39\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib39\"><span class=\"anchor-text\">[39]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">ho\u1ea1i t\u1eed<\/th>\n<td>ho\u1ea1i t\u1eed<\/td>\n<td>S\u01b0ng t\u1ebf b\u00e0o, v\u1ee1 m\u00e0ng huy\u1ebft t\u01b0\u01a1ng, s\u01b0ng c\u01a1 quan, ng\u01b0ng t\u1ee5 ch\u1ea5t nhi\u1ec5m s\u1eafc, v.v.<\/td>\n<td>Ch\u1ea5n th\u01b0\u01a1ng nghi\u00eam tr\u1ecdng<\/td>\n<td>Nec-1, NSA, v.v.<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib33\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib33\"><span class=\"anchor-text\">[33]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib40\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib40\"><span class=\"anchor-text\">[40]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib41\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib41\"><span class=\"anchor-text\">[41]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib42\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib42\"><span class=\"anchor-text\">[42]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib43\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib43\"><span class=\"anchor-text\">[43]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">b\u1ec7nh s\u1eaft t\u1eeb<\/th>\n<td>NRF2, GPX4, ACSL4, v.v.<\/td>\n<td>X\u1ea3y ra ch\u1ee7 y\u1ebfu \u1edf ty th\u1ec3, v\u1edbi c\u00e1c m\u00e0ng ty th\u1ec3 b\u1ecb suy gi\u1ea3m, m\u00e0ng ng\u01b0ng t\u1ee5 v\u00e0 m\u00e0ng ngo\u00e0i b\u1ecb v\u1ee1.<\/td>\n<td>Qu\u00e1 t\u1ea3i Fe2 + v\u00e0 ROS<\/td>\n<td>GSH, deferoxamine, lipproxstatin-1, ferrostatin-1, v.v.<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib44\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib44\"><span class=\"anchor-text\">[44]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib45\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib45\"><span class=\"anchor-text\">[45]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib46\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib46\"><span class=\"anchor-text\">[46]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib47\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib47\"><span class=\"anchor-text\">[47]<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section id=\"sec0020\">\n<h3 id=\"sect0040\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.2. C\u01a1 ch\u1ebf ph\u00e2n t\u1eed c\u1ee7a b\u1ec7nh pyroptosis<\/h3>\n<p id=\"p0040\">S\u1ef1 h\u00ecnh th\u00e0nh c\u1ee7a\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 hi\u1ec7n t\u01b0\u1ee3ng g\u00e2y s\u1ed1t t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammasome\">g\u00e2y s\u1ed1t<\/a>\u00a0l\u00e0 ch\u1ea5t ch\u1ee7 y\u1ebfu g\u00e2y pyroptosis sau ch\u1ea5n th\u01b0\u01a1ng. Khi b\u1ecb th\u01b0\u01a1ng, c\u01a1 th\u1ec3 c\u00f3 th\u1ec3 k\u00edch ho\u1ea1t t\u00edn hi\u1ec7u m\u1eabu li\u00ean quan \u0111\u1ebfn m\u1eabu ph\u00e2n t\u1eed li\u00ean quan \u0111\u1ebfn m\u1ea7m b\u1ec7nh (PAMP) v\u00e0 m\u1eabu ph\u00e2n t\u1eed li\u00ean quan \u0111\u1ebfn t\u1ed5n th\u01b0\u01a1ng (DAMP)\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib48\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib48\"><span class=\"anchor-text\">[48]<\/span><\/a>. Khi k\u00edch th\u00edch t\u00edn hi\u1ec7u x\u1ea3y ra, n\u1ed9i b\u00e0o\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 protein qu\u1ea3ng b\u00e1 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/promoter-protein\">protein th\u00fac \u0111\u1ea9y<\/a>\u00a0th\u1ee5 th\u1ec3 gi\u1ed1ng mi\u1ec1n oligome h\u00f3a li\u00ean k\u1ebft v\u1edbi nucleotide\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 mi\u1ec1n pyrin t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyrin-domain\">mi\u1ec1n pyrin<\/a>\u00a0ch\u1ee9a 3 (NLRP3) c\u00f3 th\u1ec3 tuy\u1ec3n d\u1ee5ng m\u1ed9t l\u01b0\u1ee3ng l\u1edbn Procaspase-1 b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng ph\u00e2n t\u1eed b\u1ed9 chuy\u1ec3n \u0111\u1ed5i h\u1ed3ng c\u1ea7u ASC th\u00f4ng qua qu\u00e1 tr\u00ecnh oligome h\u00f3a\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib49\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib49\"><span class=\"anchor-text\">[49]<\/span><\/a>, s\u1ef1 h\u00ecnh th\u00e0nh c\u00e1c protein t\u1ed5ng h\u1ee3p h\u1ed3ng c\u1ea7u. Procaspase-1 l\u00e0 ti\u1ec1n th\u00e2n c\u1ee7a caspase-1 v\u00e0 th\u00f4ng th\u01b0\u1eddng Procaspase-1 t\u1ed3n t\u1ea1i trong c\u01a1 th\u1ec3 d\u01b0\u1edbi d\u1ea1ng\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 zymogen t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/enzyme-precursor\">zymogen<\/a>. Khi t\u00edn hi\u1ec7u k\u00edch th\u00edch \u0111\u01b0\u1ee3c truy\u1ec1n \u0111\u1ebfn Procaspase-1, n\u00f3 s\u1ebd t\u1ea1o ra c\u00e1c ti\u1ec3u \u0111\u01a1n v\u1ecb P20 v\u00e0 P10 b\u1eb1ng qu\u00e1 tr\u00ecnh t\u1ef1 th\u1ee7y ph\u00e2n. Ti\u1ec3u \u0111\u01a1n v\u1ecb n\u00e0y \u0111\u1ea7u ti\u00ean t\u1ea1o th\u00e0nh m\u1ed9t\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 d\u1ecb v\u00f2ng t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/heterodimer\">ch\u1ea5t d\u1ecb v\u00f2ng<\/a>\u00a0kh\u00f4ng th\u1ec3 ho\u1ea1t \u0111\u1ed9ng v\u00e0 sau \u0111\u00f3 t\u1eadp h\u1ee3p l\u1ea1i \u0111\u1ec3 t\u1ea1o th\u00e0nh m\u1ed9t\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 tetramer t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tetramer\">t\u1ee9 gi\u00e1c<\/a>\u00a0th\u00fac \u0111\u1ea9y ho\u1ea1t \u0111\u1ed9ng caspase-1, d\u1eabn \u0111\u1ebfn k\u00edch ho\u1ea1t caspase-1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib50\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib50\"><span class=\"anchor-text\">[50]<\/span><\/a>. Khi caspase-1 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t, caspase-1 ho\u1ea1t \u0111\u1ed9ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m h\u00ecnh th\u00e0nh c\u00e1c l\u1ed7 m\u00e0ng t\u1ebf b\u00e0o v\u00e0 ph\u00e2n gi\u1ea3i nhanh m\u00e0ng t\u1ebf b\u00e0o \u0111\u1ec3 h\u00ecnh th\u00e0nh ph\u1ea3n \u1ee9ng vi\u00eam. Trong khi \u0111\u00f3, caspase-1 c\u0169ng c\u00f3 th\u1ec3 t\u1ea1o ra ti\u1ec1n ch\u1ea5t c\u1ee7a IL-1\u03b2 v\u00e0 IL-18, pro-IL-1\u03b2 v\u00e0 pro-IL-18, \u0111\u1ec3 \u0111\u1ea9y nhanh qu\u00e1 tr\u00ecnh tr\u01b0\u1edfng th\u00e0nh. IL-1\u03b2 v\u00e0 IL-18 tr\u01b0\u1edfng th\u00e0nh \u0111\u01b0\u1ee3c gi\u1ea3i ph\u00f3ng ngo\u1ea1i b\u00e0o, do \u0111\u00f3 thu h\u00fat nhi\u1ec1u h\u1ed3ng c\u1ea7u h\u01a1n. Sau khi t\u1eadp h\u1ee3p c\u00e1c h\u1ed3ng c\u1ea7u, ph\u1ea3n \u1ee9ng vi\u00eam s\u1ebd tr\u1edf n\u00ean tr\u1ea7m tr\u1ecdng h\u01a1n v\u00e0 t\u1ed5n th\u01b0\u01a1ng m\u00f4 s\u1ebd tr\u1ea7m tr\u1ecdng h\u01a1n. Sau khi IL-1\u03b2 \u0111\u01b0\u1ee3c gi\u1ea3i ph\u00f3ng kh\u1ecfi t\u1ebf b\u00e0o, c\u00e1c y\u1ebfu t\u1ed1 g\u00e2y vi\u00eam s\u1ebd lan sang c\u00e1c m\u00f4 l\u00e2n c\u1eadn c\u00f9ng v\u1edbi d\u00f2ng b\u1ea1ch huy\u1ebft, l\u00e0m tr\u1ea7m tr\u1ecdng th\u00eam ph\u1ea3n \u1ee9ng vi\u00eam. S\u1ef1 ti\u1ebft ra m\u1ed9t l\u01b0\u1ee3ng l\u1edbn IL-18 g\u00e2y ra ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch Th1 v\u00e0 Th2, \u0111\u1ed3ng th\u1eddi k\u00edch th\u00edch ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch \u0111\u00f3ng vai tr\u00f2\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib51\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib51\"><span class=\"anchor-text\">[51]<\/span><\/a>.<\/p>\n<section id=\"sec0025\">\n<h4 id=\"sect0045\" class=\"u-margin-m-top u-margin-xs-bottom\">2.2.1. Con \u0111\u01b0\u1eddng pyroptosis Canonical<\/h4>\n<p id=\"p0045\">Caspase-1 l\u00e0 m\u1ed9t protein quan tr\u1ecdng trong con \u0111\u01b0\u1eddng pyroptotic ch\u00ednh t\u1eafc, trong \u0111\u00f3 h\u1ed3ng c\u1ea7u \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c k\u00edch ho\u1ea1t Caspase-1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib52\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib52\"><span class=\"anchor-text\">[52]<\/span><\/a>. Inflammasome l\u00e0 m\u1ed9t ph\u1ea7n quan tr\u1ecdng c\u1ee7a h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch b\u1ea9m sinh v\u00e0 l\u00e0 m\u1ed9t ph\u1ee9c h\u1ee3p \u0111a protein bao g\u1ed3m c\u00e1c protein c\u1ea3m bi\u1ebfn, ASC v\u00e0 pro-Caspase-1. N\u00f3 t\u1ed3n t\u1ea1i trong t\u1ebf b\u00e0o ch\u1ea5t c\u1ee7a ch\u1ea5t b\u1ecb k\u00edch th\u00edch\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunocompetent-cell\">t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch<\/a>\u00a0v\u00e0 c\u00f3 th\u1ec3 c\u1ea3m nh\u1eadn \u0111\u01b0\u1ee3c c\u00e1c t\u00edn hi\u1ec7u k\u00edch th\u00edch ngo\u1ea1i b\u00e0o\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib53\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib53\"><span class=\"anchor-text\">[53]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib54\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib54\"><span class=\"anchor-text\">[54]<\/span><\/a>. C\u00e1c d\u00f2ng si\u00eau nh\u1ecf \u0111\u01b0\u1ee3c chia th\u00e0nh c\u00e1c d\u00f2ng si\u00eau nh\u1ecf ch\u1ee9a c\u00e1c th\u1ee5 th\u1ec3 gi\u1ed1ng mi\u1ec1n oligome h\u00f3a li\u00ean k\u1ebft v\u1edbi nucleotide (NLR), tr\u1eebu t\u01b0\u1ee3ng trong\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 kh\u1ed1i u \u00e1c t\u00ednh t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nodular-melanoma\">kh\u1ed1i u \u00e1c t\u00ednh<\/a>\u00a0C\u00e1c d\u00f2ng si\u00eau nh\u1ecf 2 (AIM2) v\u00e0 c\u00e1c d\u00f2ng si\u00eau nh\u1ecf NLRC4\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib55\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib55\"><span class=\"anchor-text\">[55]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib56\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib56\"><span class=\"anchor-text\">[56]<\/span><\/a>. Th\u1ee5 th\u1ec3 Purinergic 2 \u00d7 7 (P2X7) l\u00e0 m\u1ed9t th\u1ee5 th\u1ec3 k\u00eanh ion xuy\u00ean m\u00e0ng c\u00f3 c\u1ed5ng ATP \u0111\u01b0\u1ee3c bi\u1ec3u hi\u1ec7n \u1edf\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 microglia t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microglia\">microglia<\/a>\u00a0v\u00e0 l\u00e0 y\u1ebfu t\u1ed1 then ch\u1ed1t trong vi\u1ec7c k\u00edch ho\u1ea1t h\u1ed3ng c\u1ea7u. C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng ATP ngo\u1ea1i b\u00e0o c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh d\u00f2ng K+ b\u1eb1ng c\u00e1ch k\u00edch ho\u1ea1t\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 th\u1ee5 th\u1ec3 P2X7 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/purinergic-p2x7-receptor\">Th\u1ee5 th\u1ec3 P2X7<\/a>, k\u00edch ho\u1ea1t h\u1ecd NLR, ch\u1ee9a mi\u1ec1n pyrin 3 (NLRP3)\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib57\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib57\"><span class=\"anchor-text\">[57]<\/span><\/a>. D\u00f2ng si\u00eau nh\u1ecf NLRP3 hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u nhi\u1ec1u nh\u1ea5t. Vi\u1ec7c k\u00edch ho\u1ea1t d\u00f2ng si\u00eau nh\u1ecf NLRP3 y\u00eau c\u1ea7u ph\u1ea3n \u1ee9ng g\u1ed3m hai b\u01b0\u1edbc: b\u1eaft \u0111\u1ea7u ph\u1ea3n \u1ee9ng, y\u1ebfu t\u1ed1 h\u1ea1t nh\u00e2n vi khu\u1ea9n ho\u1eb7c n\u1ed9i sinh-\u03baB (NF-\u03baB) v\u00e0o nh\u00e2n v\u00e0 \u0111i\u1ec1u h\u00f2a l\u1ea1i bi\u1ec3u hi\u1ec7n NLRP3 v\u00e0 pro-IL-1\u03b2\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib58\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib58\"><span class=\"anchor-text\">[58]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib59\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib59\"><span class=\"anchor-text\">[59]<\/span><\/a>. Khi c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch \u0111\u01b0\u1ee3c k\u00edch th\u00edch b\u1edfi DAMPs, protein c\u1ea3m bi\u1ebfn s\u1ebd tuy\u1ec3n d\u1ee5ng pro-Caspase-1 th\u00f4ng qua ASC, sau \u0111\u00f3 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t b\u1eb1ng qu\u00e1 tr\u00ecnh t\u1ef1 th\u1ee7y ph\u00e2n. Caspase-1 tr\u01b0\u1edfng th\u00e0nh x\u1eed l\u00fd pro-IL-1\u03b2 v\u00e0 pro-IL-18 kh\u00f4ng ho\u1ea1t \u0111\u1ed9ng xu\u00f4i d\u00f2ng th\u00e0nh IL-1\u03b2 v\u00e0 IL-18 ho\u1ea1t \u0111\u1ed9ng\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib60\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib60\"><span class=\"anchor-text\">[60]<\/span><\/a>. Trong khi \u0111\u00f3, Caspase-1 t\u00e1ch protein GSDMD xu\u00f4i d\u00f2ng th\u00e0nh \u0111o\u1ea1n GSDMD-N v\u00e0 \u0111o\u1ea1n GSDMD-C v\u1edbi ho\u1ea1t \u0111\u1ed9ng t\u1ea1o l\u1ed7 ch\u00e2n l\u00f4ng. \u0110o\u1ea1n GSDMD-N nh\u1eadn bi\u1ebft v\u00e0 li\u00ean k\u1ebft c\u1ee5 th\u1ec3 v\u1edbi\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 lipid m\u00e0ng t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/membrane-lipid\">lipid m\u00e0ng<\/a>\u00a0\u1edf m\u1eb7t trong c\u1ee7a m\u00e0ng t\u1ebf b\u00e0o, g\u00e2y ra nh\u1eefng thay \u0111\u1ed5i v\u1ec1 \u00e1p su\u1ea5t th\u1ea9m th\u1ea5u n\u1ed9i b\u00e0o v\u00e0 ngo\u1ea1i b\u00e0o, t\u1eeb \u0111\u00f3 d\u1eabn \u0111\u1ebfn s\u01b0ng t\u1ea5y, v\u1ee1 t\u1ebf b\u00e0o v\u00e0 gi\u1ea3i ph\u00f3ng c\u00e1c y\u1ebfu t\u1ed1 g\u00e2y vi\u00eam IL-1\u03b2 v\u00e0 IL-18, g\u00e2y ra ph\u1ea3n \u1ee9ng vi\u00eam v\u00e0 ch\u1ee9ng pyroptosis t\u1ebf b\u00e0o\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib61\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib61\"><span class=\"anchor-text\">[61]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0030\">\n<h4 id=\"sect0050\" class=\"u-margin-m-top u-margin-xs-bottom\">2.2.2. Con \u0111\u01b0\u1eddng pyroptosis kh\u00f4ng ch\u00ednh t\u1eafc<\/h4>\n<p id=\"p0050\">H\u1ecd Caspase ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c chia th\u00e0nh hai lo\u1ea1i: li\u00ean quan \u0111\u1ebfn apoptosis v\u00e0 li\u00ean quan \u0111\u1ebfn vi\u00eam theo c\u00e1c ch\u1ee9c n\u0103ng kh\u00e1c nhau. Caspase-3\/2\/10 ch\u1ee7 y\u1ebfu l\u00e0m trung gian cho qu\u00e1 tr\u00ecnh apoptosis, trong khi caspase-1\/4\/5\/11 l\u00e0 ch\u1ea5t trung gian ch\u00ednh c\u1ee7a t\u00ecnh tr\u1ea1ng vi\u00eam v\u00e0 ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch b\u1ea9m sinh\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib62\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib62\"><span class=\"anchor-text\">[62]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib63\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib63\"><span class=\"anchor-text\">[63]<\/span><\/a>. Con \u0111\u01b0\u1eddng pyroptotic kh\u00f4ng ch\u00ednh t\u1eafc ph\u1ee5 thu\u1ed9c v\u00e0o k\u00edch ho\u1ea1t Caspase-4\/5\/11, trong khi \u0111\u00f3 d\u00f2ng h\u1ed3ng c\u1ea7u kh\u00f4ng c\u1ea7n thi\u1ebft cho s\u1ef1 tr\u01b0\u1edfng th\u00e0nh c\u1ee7a IL-1\u03b2 v\u00e0 IL-18\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib64\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib64\"><span class=\"anchor-text\">[64]<\/span><\/a>. Con \u0111\u01b0\u1eddng phi c\u1ed5 \u0111i\u1ec3n c\u1ee7a b\u1ec7nh pyroptosis \u0111\u01b0\u1ee3c g\u00e2y ra b\u1edfi\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 lipopolysaccharide t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/lipopolysaccharide\">lipopolysacarit<\/a>\u00a0(LPS), th\u00e0nh ph\u1ea7n th\u00e0nh t\u1ebf b\u00e0o c\u1ee7a vi khu\u1ea9n gram \u00e2m. LPS c\u00f3 th\u1ec3 li\u00ean k\u1ebft tr\u1ef1c ti\u1ebfp v\u1edbi Caspase-4\/5 c\u1ee7a con ng\u01b0\u1eddi v\u00e0 chu\u1ed9t Caspase-11. Nh\u1eefng caspase n\u00e0y ho\u1ea1t \u0111\u1ed9ng nh\u01b0 c\u1ea3 protein c\u1ea3m bi\u1ebfn v\u00e0 ph\u00e2n t\u1eed t\u00e1c \u0111\u1ed9ng c\u1ee7a LPS. Caspase-4\/5\/11 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t tr\u1ef1c ti\u1ebfp ph\u00e2n c\u1eaft GSDMD v\u00e0 g\u00e2y ra b\u1ec7nh pyroptosis\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib65\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib65\"><span class=\"anchor-text\">[65]<\/span><\/a>. Ngo\u00e0i ra, c\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng Caspase-11 c\u00f3 th\u1ec3 k\u00edch ho\u1ea1t qu\u00e1 tr\u00ecnh h\u1ea1 l\u01b0u\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 m\u1ed1i n\u1ed1i kho\u1ea3ng c\u00e1ch t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/gap-junction\">ng\u00e3 ba kho\u1ea3ng c\u00e1ch<\/a>\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 protein k\u00eanh t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/channel-protein\">protein k\u00eanh<\/a>\u00a0Pannexin-1 \u0111\u1ec3 th\u00fac \u0111\u1ea9y d\u00f2ng ch\u1ea3y K+ v\u00e0 d\u00f2ng ch\u1ea3y K+ c\u00f3 th\u1ec3 k\u00edch ho\u1ea1t d\u00f2ng si\u00eau nh\u1ecf NLRP3, t\u1eeb \u0111\u00f3 k\u00edch ho\u1ea1t Caspase-1 v\u00e0 th\u00fac \u0111\u1ea9y s\u1ef1 tr\u01b0\u1edfng th\u00e0nh c\u1ee7a IL-1\u03b2 v\u00e0 IL-18\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib66\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib66\"><span class=\"anchor-text\">[66]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0035\">\n<h4 id=\"sect0055\" class=\"u-margin-m-top u-margin-xs-bottom\">2.2.3. M\u1ed1i quan h\u1ec7 gi\u1eefa GSDMD v\u00e0 b\u1ec7nh pyroptosis<\/h4>\n<p id=\"p0055\">GSDMD (Gsdermin D) l\u00e0 m\u1ed9t protein bao g\u1ed3m 484 m\u1ea3nh d\u01b0 l\u01b0\u1ee3ng axit amin v\u00e0 l\u00e0 th\u00e0nh vi\u00ean c\u1ee7a h\u1ecd protein Gasdermin. Ch\u1ee7 y\u1ebfu c\u00f3 5 th\u00e0nh vi\u00ean trong h\u1ecd n\u00e0y l\u00e0: DFNA5, DFNB59, GSDMA, GSDMB, GSDMCD. C\u1ea5u tr\u00fac axit amin c\u1ee7a n\u0103m lo\u1ea1i protein n\u00e0y r\u1ea5t gi\u1ed1ng nhau v\u00e0 nh\u1eefng protein n\u00e0y ch\u1ee9a hai mi\u1ec1n kh\u00f4ng gian, \u0111\u1ea7u N v\u00e0 \u0111\u1ea7u C.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib67\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib67\"><span class=\"anchor-text\">[67]<\/span><\/a>. Protein GSDMD l\u00e0 m\u1ed9t amino chu\u1ed7i d\u00e0i\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 protein axit t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/acid-protein\">protein axit<\/a>v\u00e0 c\u1ea5u tr\u00fac gi\u1eefa mi\u1ec1n N-terminal v\u00e0 C-terminal c\u1ee7a n\u00f3 t\u01b0\u01a1ng \u0111\u1ed1i l\u1ecfng l\u1ebbo. GSDMD th\u01b0\u1eddng \u0111\u01b0\u1ee3c c\u1eaft \u1edf\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 tr\u00ecnh t\u1ef1 axit amin t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/peptide-sequence\">tr\u00ecnh t\u1ef1 axit amin<\/a>\u00a0275, hi\u1ec3n th\u1ecb mi\u1ec1n N-terminal v\u00e0 C-terminal. TRONG\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 t\u1ebf b\u00e0o \u0111\u1ed9ng v\u1eadt c\u00f3 v\u00fa t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mammalian-cell\">t\u1ebf b\u00e0o \u0111\u1ed9ng v\u1eadt c\u00f3 v\u00fa<\/a>, c\u1ea5u tr\u00fac \u0111\u1ea7u N \u0111\u01a1n gi\u1ea3n c\u1ee7a GSDMD c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh qu\u00e1 tr\u00ecnh pyroptosis c\u1ee7a t\u1ebf b\u00e0o. Do \u0111\u00f3, GSDMD th\u01b0\u1eddng bi\u1ec3u th\u1ecb mi\u1ec1n N-terminal nh\u01b0ng kh\u00f4ng th\u1ec3 bi\u1ec3u th\u1ecb t\u1ea5t c\u1ea3 c\u00e1c protein GSDMD\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib68\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib68\"><span class=\"anchor-text\">[68]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib69\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib69\"><span class=\"anchor-text\">[69]<\/span><\/a>. Tuy nhi\u00ean, c\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng khi mi\u1ec1n N-terminal c\u1ee7a GSDMD \u0111\u01b0\u1ee3c \u0111\u01b0a v\u00e0o E. coli \u0111\u1ec3 nu\u00f4i c\u1ea5y, t\u00e1c d\u1ee5ng \u0111\u1ed9c h\u1ea1i m\u1ea1nh \u0111\u00e3 x\u1ea3y ra. Ng\u01b0\u1ee3c l\u1ea1i, GSDMD nguy\u00ean v\u1eb9n v\u00e0 mi\u1ec1n \u0111\u1ea7u C c\u1ee7a GSDMD cho th\u1ea5y \u0111\u1ed9c t\u00ednh t\u01b0\u01a1ng \u0111\u1ed1i th\u1ea5p\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib70\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib70\"><span class=\"anchor-text\">[70]<\/span><\/a>. C\u1ea5u tr\u00fac \u0111\u1ea7u N c\u1ee7a GSDMD n\u1ed9i b\u00e0o s\u1ebd d\u1ea7n d\u1ea7n chuy\u1ec3n sang m\u00e0ng t\u1ebf b\u00e0o v\u1edbi s\u1ef1 x\u00e2m nh\u1eadp c\u1ee7a c\u00e1c y\u1ebfu t\u1ed1 g\u00e2y t\u1ed5n h\u1ea1i v\u00e0 tr\u00ean m\u00e0ng t\u1ebf b\u00e0o, n\u01a1i n\u00f3 li\u00ean k\u1ebft \u0111\u1eb7c bi\u1ec7t v\u1edbi phosphosarcosinase v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 phosphatidylserine t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/phosphatidylserine\">phosphatidylserine<\/a>\u00a0tr\u00ean m\u00e0ng t\u1ebf b\u00e0o \u0111\u1ec3 t\u1ea1o ra t\u00e1c d\u1ee5ng sinh h\u1ecdc\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib71\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib71\"><span class=\"anchor-text\">[71]<\/span><\/a>. S\u1eed d\u1ee5ng thi\u1ebft b\u1ecb nh\u01b0 l\u1ef1c nguy\u00ean t\u1eed\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 k\u00ednh hi\u1ec3n vi \u0111i\u1ec7n t\u1eed t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/electron-microscopy\">k\u00ednh hi\u1ec3n vi \u0111i\u1ec7n t\u1eed<\/a>\u00a0v\u00e0 k\u00ednh hi\u1ec3n vi \u0111i\u1ec7n t\u1eed l\u1ea1nh, L. Sborigi \u0111\u00e3 quan s\u00e1t th\u1ea5y c\u1ea5u tr\u00fac \u0111\u1ea7u N c\u1ee7a GSDMD c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c k\u1ebft h\u1ee3p v\u1edbi m\u00e0ng sinh h\u1ecdc \u0111\u1ec3 t\u1ea1o th\u00e0nh polyme d\u1ea1ng v\u00f2ng r\u1ed7ng tr\u00ean m\u00e0ng sinh h\u1ecdc. Polyme n\u00e0y g\u00e2y ra s\u1ef1 h\u00ecnh th\u00e0nh c\u00e1c l\u1ed7 m\u00e0ng sinh h\u1ecdc, do \u0111\u00f3 GSDMD g\u00e2y ra hi\u1ec7n t\u01b0\u1ee3ng pyroptosis trong t\u1ebf b\u00e0o khi x\u1ea3y ra t\u1ed5n th\u01b0\u01a1ng n\u1ed9i sinh. Khi \u1edf b\u00ean ngo\u00e0i\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 m\u1ea7m b\u1ec7nh t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathogen\">m\u1ea7m b\u1ec7nh<\/a>\u00a0x\u00e2m nh\u1eadp, ch\u00fang c\u00f3 kh\u1ea3 n\u0103ng h\u1ea5p ph\u1ee5 m\u1ea7m b\u1ec7nh tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o v\u00e0 b\u1ea3o v\u1ec7 c\u01a1 th\u1ec3 kh\u1ecfi c\u00e1c ch\u1ea5t c\u00f3 h\u1ea1i b\u00ean ngo\u00e0i b\u1eb1ng c\u00e1ch ly gi\u1ea3i t\u1ebf b\u00e0o\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib72\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib72\"><span class=\"anchor-text\">[72]<\/span><\/a>. GSDMD l\u00e0 m\u1ed9t ch\u1ea5t li\u00ean k\u1ebft \u0111\u1eb7c bi\u1ec7t v\u1edbi protein caspase-1\/4\/5\/11 \u1edf h\u1ea1 l\u01b0u c\u1ee7a\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 vi\u1ec7c truy\u1ec1n t\u00edn hi\u1ec7u t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/signal-transduction\">truy\u1ec1n t\u00edn hi\u1ec7u<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib73\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib73\"><span class=\"anchor-text\">[73]<\/span><\/a>. Caspase-1 th\u00fac \u0111\u1ea9y gi\u1ea3i ph\u00f3ng IL-1\u03b2 v\u00e0 IL-18 \u1edf h\u1ea1 l\u01b0u ra kh\u1ecfi m\u00e0ng t\u1ebf b\u00e0o th\u00f4ng qua c\u00e1c ph\u1ea3n \u1ee9ng h\u1ed3ng c\u1ea7u \u0111\u01b0\u1ee3c t\u1ea1o ra b\u1edfi c\u00e1c ph\u1ee9c h\u1ee3p v\u1edbi nhi\u1ec1u lo\u1ea1i protein kh\u00e1c nhau. Caspase-1 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t s\u1ebd t\u00e1ch protein GSDMD, chuy\u1ec3n GSDMD th\u00e0nh c\u00e1c peptide ho\u1ea1t \u0111\u1ed9ng. C\u00e1c s\u1ea3n ph\u1ea9m ph\u00e2n h\u1ee7y c\u1ee7a GSDMD li\u00ean k\u1ebft \u0111\u1eb7c bi\u1ec7t v\u1edbi m\u00e0ng t\u1ebf b\u00e0o v\u00e0 c\u00e1c th\u00e0nh ph\u1ea7n nh\u01b0 ph\u00e2n t\u1eed n\u01b0\u1edbc ngo\u1ea1i b\u00e0o x\u00e2m nh\u1eadp v\u00e0o m\u00e0ng t\u1ebf b\u00e0o qua c\u00e1c l\u1ed7 ch\u00e2n l\u00f4ng, khi\u1ebfn t\u1ebf b\u00e0o s\u01b0ng l\u00ean v\u00e0 cu\u1ed1i c\u00f9ng v\u1ee1 ra\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib74\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib74\"><span class=\"anchor-text\">[74]<\/span><\/a>.<\/p>\n<\/section>\n<\/section>\n<section id=\"sec0040\">\n<h3 id=\"sect0060\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.3. C\u00e1c RNA kh\u00f4ng m\u00e3 h\u00f3a tham gia v\u00e0o qu\u00e1 tr\u00ecnh bi\u1ec3u hi\u1ec7n gen pyroptotic trong IS<\/h3>\n<p id=\"p0060\">Trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, c\u01a1 ch\u1ebf \u0111i\u1ec1u h\u00f2a \u1edf c\u1ea5p \u0111\u1ed9 gen li\u00ean quan \u0111\u1ebfn s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a b\u1ec7nh pyroptosis c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n \u0111\u1ea7y \u0111\u1ee7. C\u00e1c nghi\u00ean c\u1ee9u sinh h\u1ecdc ph\u00e2n t\u1eed hi\u1ec7n \u0111\u1ea1i cho th\u1ea5y 98% c\u1ee7a b\u1ed9 gen kh\u00f4ng li\u00ean quan \u0111\u1ebfn vi\u1ec7c m\u00e3 h\u00f3a protein. RNA m\u00e3 h\u00f3a chu\u1ed7i d\u00e0i (lncRNA) l\u00e0 c\u00e1c RNA kh\u00f4ng c\u00f3 ch\u1ee9c n\u0103ng m\u00e3 h\u00f3a protein, \u0111\u01b0\u1ee3c \u0111\u1eb7t t\u00ean nh\u01b0 v\u1eady v\u00ec ch\u00fang c\u00f3 chi\u1ec1u d\u00e0i h\u01a1n 200 nucleotide\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib75\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib75\"><span class=\"anchor-text\">[75]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib76\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib76\"><span class=\"anchor-text\">[76]<\/span><\/a>. Tuy nhi\u00ean, m\u1eb7c d\u00f9\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 lncRNA t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/long-untranslated-rna\">lncRNA<\/a>\u00a0kh\u00f4ng c\u00f3 ch\u1ee9c n\u0103ng m\u00e3 h\u00f3a protein, l\u00e0 gen \u0111\u01b0\u1ee3c bi\u1ec3u hi\u1ec7n nhi\u1ec1u nh\u1ea5t trong c\u01a1 th\u1ec3 v\u00e0 l\u00e0 gen \u0111\u01b0\u1ee3c b\u1ea3o t\u1ed3n nhi\u1ec1u nh\u1ea5t trong qu\u00e1 tr\u00ecnh phi\u00ean m\u00e3. N\u00f3 tham gia v\u00e0o c\u00e1c qu\u00e1 tr\u00ecnh b\u1ec7nh l\u00fd v\u00e0 sinh l\u00fd quan tr\u1ecdng trong c\u01a1 th\u1ec3, \u0111\u1eb7c bi\u1ec7t l\u00e0 trong c\u00e1c b\u1ec7nh li\u00ean quan \u0111\u1ebfn ch\u1ea5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u v\u00e0 \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib77\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib77\"><span class=\"anchor-text\">[77]<\/span><\/a>. C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng \u1edf microglia, m\u1ee9c \u0111\u1ed9 bi\u1ec3u hi\u1ec7n c\u1ee7a lncRNA-H19 c\u00f3 m\u1ed1i t\u01b0\u01a1ng quan thu\u1eadn v\u1edbi th\u1eddi gian t\u00e1i t\u01b0\u1edbi m\u00e1u\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib78\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib78\"><span class=\"anchor-text\">[78]<\/span><\/a>. S\u1ef1 bi\u1ec3u hi\u1ec7n qu\u00e1 m\u1ee9c c\u1ee7a LncRNA-H19 \u0111\u00f3ng vai tr\u00f2 g\u00e2y vi\u00eam khi n\u00f3 th\u00fac \u0111\u1ea9y s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a ph\u00e2n t\u1eed t\u00edn hi\u1ec7u xu\u00f4i d\u00f2ng NLRP3\/6 v\u00e0 kh\u1edfi \u0111\u1ea7u GSDMD\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib79\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib79\"><span class=\"anchor-text\">[79]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib80\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib80\"><span class=\"anchor-text\">[80]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib81\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib81\"><span class=\"anchor-text\">[81]<\/span><\/a>. lncRNA-H19 c\u00f3 th\u1ec3 k\u00edch ho\u1ea1t c\u00e1c th\u00e0nh vi\u00ean c\u1ee7a h\u1ecd protein caspase\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib82\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib82\"><span class=\"anchor-text\">[82]<\/span><\/a>, d\u1eabn \u0111\u1ebfn r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng ty th\u1ec3, tham gia k\u00edch ho\u1ea1t c\u00e1c t\u1ebf b\u00e0o vi\u00eam v\u00e0 g\u00e2y t\u1ed5n th\u01b0\u01a1ng t\u1ebf b\u00e0o th\u1ea7n kinh\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib83\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib83\"><span class=\"anchor-text\">[83]<\/span><\/a>. Ngo\u00e0i vi\u1ec7c \u0111i\u1ec1u h\u00f2a c\u1ea5u tr\u00fac ph\u00e2n t\u1eed, lncRNA-H19 c\u00f2n c\u00f3 th\u1ec3 tuy\u1ec3n d\u1ee5ng th\u00eam c\u00e1c y\u1ebfu t\u1ed1 phi\u00ean m\u00e3 \u0111\u1ec3 \u0111i\u1ec1u ch\u1ec9nh qu\u00e1 tr\u00ecnh phi\u00ean m\u00e3 mRNA\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib84\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib84\"><span class=\"anchor-text\">[84]<\/span><\/a>. Ngo\u00e0i ra, lncRNA-H19 c\u0169ng c\u00f3 th\u1ec3 th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 v\u1eadn chuy\u1ec3n h\u1ea1t nh\u00e2n t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nucleocytoplasmic-transport\">v\u1eadn chuy\u1ec3n h\u1ea1t nh\u00e2n<\/a>\u00a0qu\u00e1 tr\u00ecnh c\u1ee7a c\u00e1c y\u1ebfu t\u1ed1 phi\u00ean m\u00e3, t\u1eeb \u0111\u00f3 l\u00e0m t\u0103ng s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee5 th\u1ec3 c\u1ee7a nhi\u1ec1u gen m\u1ee5c ti\u00eau h\u01a1n v\u00e0 t\u1ea1o ra m\u1ea1ng l\u01b0\u1edbi t\u1ea7ng vi\u00eam khi\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 b\u1ec7nh thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemia\">thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9<\/a>\u00a0x\u1ea3y ra\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib84\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib84\"><span class=\"anchor-text\">[84]<\/span><\/a>. V\u00ec v\u1eady, lncRNA-H19 l\u00e0 t\u00edn hi\u1ec7u nguy hi\u1ec3m m\u1ea1nh khi\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 CIRI t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunoreactive-insulin\">CIRI<\/a>\u00a0x\u1ea3y ra v\u00e0 s\u1ef1 \u1ee9c ch\u1ebf H19 c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t kh\u1ea3 n\u0103ng\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1ch \u0111i\u1ec1u tr\u1ecb t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/therapeutic-procedure\">s\u1ef1 \u0111\u1ed1i \u0111\u00e3i<\/a>\u00a0\u0111\u1ed1i v\u1edbi t\u1ed5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib84\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib84\"><span class=\"anchor-text\">[84]<\/span><\/a>. Trong b\u1ec7nh pyroptosis qua trung gian h\u1ed3ng c\u1ea7u AIM2 c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y t\u1ed5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9, tr\u1ee5c lincRNA MEG3\/miR-485\/AIM2 th\u00fac \u0111\u1ea9y b\u1ec7nh pyroptosis b\u1eb1ng c\u00e1ch k\u00edch ho\u1ea1t t\u00edn hi\u1ec7u caspase1 trong CIRI, v\u00e0 do \u0111\u00f3 tr\u1ee5c n\u00e0y c\u00f3 th\u1ec3 l\u00e0 m\u1ee5c ti\u00eau \u0111i\u1ec1u tr\u1ecb hi\u1ec7u qu\u1ea3 cho\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 IS t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/brain-ischemia\">L\u00c0<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib84\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib84\"><span class=\"anchor-text\">[84]<\/span><\/a>. Cho\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 quy \u0111\u1ecbnh mi\u1ec5n d\u1ecbch t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunoregulation\">\u0111i\u1ec1u h\u00f2a mi\u1ec5n d\u1ecbch<\/a>\u00a0c\u1ee7a microglia, Wang v\u00e0 c\u1ed9ng s\u1ef1. ph\u00e1t hi\u1ec7n ra r\u1eb1ng LncRNA-Fendrr b\u1ea3o v\u1ec7\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 ph\u1ed5 bi\u1ebfn t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ubiquitination\">s\u1ef1 ph\u1ed5 bi\u1ebfn kh\u1eafp n\u01a1i<\/a>\u00a0v\u00e0 s\u1ef1 tho\u00e1i bi\u1ebfn c\u1ee7a protein NLRC4 th\u00f4ng qua HERC2 v\u00e0 \u0111i\u1ec1u ch\u1ec9nh b\u1ec7nh pyroptosis vi m\u00f4\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib85\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib85\"><span class=\"anchor-text\">[85]<\/span><\/a>. Zhang v\u00e0 c\u1ed9ng s\u1ef1. ph\u00e1t hi\u1ec7n ra r\u1eb1ng tr\u1ee5c lncRNA NEAT1\/miR-22\u20133p \u0111\u00e3 \u1ee9c ch\u1ebf ch\u1ee9ng pyroptosis v\u00e0 l\u00e0m gi\u1ea3m t\u1ed5n th\u01b0\u01a1ng CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib86\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib86\"><span class=\"anchor-text\">[86]<\/span><\/a>. C\u00e1c th\u00ed nghi\u1ec7m g\u00e2y t\u1ed5n th\u01b0\u01a1ng do thi\u1ebfu oxy-glucose (OGD) trong \u1ed1ng nghi\u1ec7m sau IS cho th\u1ea5y OGD l\u00e0m t\u0103ng bi\u1ec3u hi\u1ec7n protein th\u1ee5 th\u1ec3 gi\u1ed1ng NOD 3 (NLRP3) \u0111\u1ec3 g\u00e2y ra c\u00e1i ch\u1ebft do pyroptotic c\u1ee7a NSC, \u0111\u01b0\u1ee3c gi\u1ea3i c\u1ee9u b\u1eb1ng c\u00e1ch\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 li\u1ec7u ph\u00e1p oxy cao \u00e1p t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hyperbaric-medicine\">\u0110i\u1ec1u tr\u1ecb oxy b\u1eb1ng kh\u00ed \u00e1p hyperbaric<\/a>. LncRNA-H19 \u0111\u01b0\u1ee3c \u0111i\u1ec1u h\u00f2a ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t mi\u1ebfng b\u1ecdt bi\u1ec3n ph\u00e2n t\u1eed cho miR-423\u20135p, nh\u1eafm m\u1ee5c ti\u00eau NLRP3 sau OGD \u0111\u1ec3 g\u00e2y ra b\u1ec7nh pyroptosis t\u1ebf b\u00e0o g\u1ed1c th\u1ea7n kinh (NSC). Do \u0111\u00f3, ng\u01b0\u1eddi ta \u0111\u00e3 x\u00e1c nh\u1eadn r\u1eb1ng li\u1ec7u ph\u00e1p oxy cao \u00e1p b\u1ea3o v\u1ec7 NSC kh\u1ecfi b\u1ec7nh pyroptosis b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf tr\u1ee5c lncRNA-H19\/miR-423\u20135p\/NLRP3\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib87\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib87\"><span class=\"anchor-text\">[87]<\/span><\/a>. miR-21 l\u00e0 m\u1ed9t\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 microRNA t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microrna\">microRNA<\/a>\u00a0(miRNA) c\u00f3 li\u00ean quan ch\u1eb7t ch\u1ebd \u0111\u1ebfn s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a b\u1ec7nh pyroptosis. C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng miR-21 c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh c\u1ee5 th\u1ec3 protein NLRP3, k\u00edch ho\u1ea1t protein NLRP3, k\u00edch th\u00edch b\u00e0i ti\u1ebft NLRP3 v\u00e0 bi\u1ec3u hi\u1ec7n trong c\u00e1c \u0111\u1ea1i th\u1ef1c b\u00e0o th\u00f4ng qua t\u00edn hi\u1ec7u NF-\u03baB th\u00f4ng qua con \u0111\u01b0\u1eddng ph\u1ea3n h\u1ed3i vi\u00eam\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib88\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib88\"><span class=\"anchor-text\">[88]<\/span><\/a>. Ngo\u00e0i vi\u1ec7c k\u00edch ho\u1ea1t NLRP3, miR-21 c\u00f2n c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh vi\u1ec7c k\u00edch ho\u1ea1t caspase-1 \u1edf h\u1ea1 l\u01b0u, th\u00fac \u0111\u1ea9y s\u1ef1 ti\u1ebft IL-1\u03b2 v\u00e0 th\u00fac \u0111\u1ea9y s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a b\u1ec7nh pyroptosis. Khi thi\u1ebfu miR-21, bi\u1ec3u hi\u1ec7n c\u1ee7a con \u0111\u01b0\u1eddng caspase-1 do NLRP3 \u0111i\u1ec1u ch\u1ec9nh s\u1ebd gi\u1ea3m \u0111\u00e1ng k\u1ec3. Do \u0111\u00f3, m\u1ee9c \u0111\u1ed9 bi\u1ec3u hi\u1ec7n c\u1ee7a miR-21 c\u0169ng l\u00e0 m\u1eaft x\u00edch quan tr\u1ecdng trong vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a b\u1ec7nh pyroptosis\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib89\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib89\"><span class=\"anchor-text\">[89]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib90\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib90\"><span class=\"anchor-text\">[90]<\/span><\/a>. C\u00e1c nghi\u00ean c\u1ee9u sinh h\u1ecdc ph\u00e2n t\u1eed hi\u1ec7n \u0111\u1ea1i \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng miR-214\u20133p c\u00f3 v\u1ecb tr\u00ed g\u1eafn k\u1ebft v\u1edbi caspase-1, c\u00f3 th\u1ec3 li\u00ean k\u1ebft \u0111\u1eb7c bi\u1ec7t v\u1edbi s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a caspase-1, t\u1eeb \u0111\u00f3 \u0111i\u1ec1u ch\u1ec9nh ph\u1ea3n \u1ee9ng vi\u00eam v\u00e0 t\u0103ng t\u1ef7 l\u1ec7 m\u1eafc b\u1ec7nh pyroptosis\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib91\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib91\"><span class=\"anchor-text\">[91]<\/span><\/a>.<\/p>\n<div>\n<p id=\"p0065\">C\u01a1 ch\u1ebf ph\u00e2n t\u1eed c\u1ee7a b\u1ec7nh pyroptosis \u0111\u01b0\u1ee3c t\u00f3m t\u1eaft trong\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#fig0005\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"fig0005\"><span class=\"anchor-text\">H\u00ecnh 1<\/span><\/a>.<\/p>\n<figure id=\"fig0005\" class=\"figure text-xs\"><img decoding=\"async\" src=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr1.jpg\" alt=\"Fig. 1\" height=\"414\" aria-describedby=\"cap0005\" \/><\/p>\n<ol class=\"u-margin-s-bottom\">\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"T\u1ea3i xu\u1ed1ng h\u00ecnh \u1ea3nh c\u00f3 \u0111\u1ed9 ph\u00e2n gi\u1ea3i cao (294KB)\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr1_lrg.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">T\u1ea3i xu\u1ed1ng :\u00a0<span class=\"download-link-title\">T\u1ea3i xu\u1ed1ng h\u00ecnh \u1ea3nh c\u00f3 \u0111\u1ed9 ph\u00e2n gi\u1ea3i cao (294KB)<\/span><\/span><\/a><\/li>\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"T\u1ea3i xu\u1ed1ng h\u00ecnh \u1ea3nh k\u00edch th\u01b0\u1edbc \u0111\u1ea7y \u0111\u1ee7\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr1.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">T\u1ea3i xu\u1ed1ng :\u00a0<span class=\"download-link-title\">T\u1ea3i xu\u1ed1ng h\u00ecnh \u1ea3nh k\u00edch th\u01b0\u1edbc \u0111\u1ea7y \u0111\u1ee7<\/span><\/span><\/a><\/li>\n<\/ol>\n<p id=\"sp0005\"><span class=\"label\">H\u00ecnh 1<\/span>. C\u01a1 ch\u1ebf ph\u00e2n t\u1eed c\u1ee7a b\u1ec7nh pyroptosis (C\u00e1c c\u01a1 ch\u1ebf c\u1ee7a b\u1ec7nh pyroptosis bao g\u1ed3m con \u0111\u01b0\u1eddng vi\u00eam nhi\u1ec5m ch\u00ednh t\u1eafc v\u00e0 con \u0111\u01b0\u1eddng vi\u00eam nhi\u1ec5m kh\u00f4ng ch\u00ednh t\u1eafc. Con \u0111\u01b0\u1eddng vi\u00eam nhi\u1ec5m ch\u00ednh t\u1eafc \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t b\u1edfi DAMPs ho\u1eb7c PAMPs. Con \u0111\u01b0\u1eddng vi\u00eam nhi\u1ec5m kh\u00f4ng ch\u00ednh t\u1eafc \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t b\u1edfi LPS c\u1ee7a vi khu\u1ea9n gram \u00e2m ngo\u1ea1i b\u00e0o ho\u1eb7c k\u00edch th\u00edch t\u1eed vong.Sau khi k\u00edch ho\u1ea1t, pyroptosis \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t th\u00f4ng qua m\u1ed9t lo\u1ea1t c\u00e1c t\u01b0\u01a1ng t\u00e1c gi\u1eefa c\u00e1c ph\u00e2n t\u1eed.\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 TLR t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/toll-like-receptor\">TLR<\/a>: C\u01a1 quan th\u1ee5 c\u1ea3m gi\u1ed1ng thu ph\u00ed; GSDM: Gsdermin; NLRP3: th\u1ee5 th\u1ec3 gi\u1ed1ng mi\u1ec1n oligome h\u00f3a li\u00ean k\u1ebft v\u1edbi nucleotide\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 mi\u1ec1n pyrin t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyrin-domain\">mi\u1ec1n pyrin<\/a>\u00a0ch\u1ee9a 3; DAMP: m\u00f4 h\u00ecnh ph\u00e2n t\u1eed li\u00ean quan \u0111\u1ebfn thi\u1ec7t h\u1ea1i; PAMP: m\u1eabu ph\u00e2n t\u1eed li\u00ean quan \u0111\u1ebfn m\u1ea7m b\u1ec7nh).<\/p>\n<\/figure>\n<\/div>\n<\/section>\n<section id=\"sec0045\">\n<h3 id=\"sect0065\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.4. M\u1ed1i quan h\u1ec7 gi\u1eefa pyroptosis v\u00e0 t\u1ed5n th\u01b0\u01a1ng t\u1ebf b\u00e0o kh\u00e1c<\/h3>\n<p id=\"p0070\">C\u00f3 nhi\u1ec1u c\u01a1 ch\u1ebf li\u00ean quan \u0111\u1ebfn s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a t\u1ed5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9. C\u00e1c c\u01a1 ch\u1ebf \u0111\u00e3 bi\u1ebft c\u00f3 li\u00ean quan \u0111\u1ebfn nhi\u1ec1u c\u01a1 ch\u1ebf kh\u00e1c nhau nh\u01b0 ph\u1ea3n \u1ee9ng vi\u00eam, r\u1ed1i lo\u1ea1n k\u00eanh canxi, suy gi\u1ea3m ch\u1ee9c n\u0103ng ty th\u1ec3 v\u00e0 b\u1ec7nh t\u1ef1 th\u1ef1c. Pyroptosis li\u00ean quan \u0111\u1ebfn t\u1ea5t c\u1ea3 c\u00e1c kh\u00eda c\u1ea1nh c\u1ee7a ch\u1ea5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 v\u00e0 li\u00ean quan ch\u1eb7t ch\u1ebd \u0111\u1ebfn c\u00e1c ch\u1ea5n th\u01b0\u01a1ng kh\u00e1c.<\/p>\n<p id=\"p0075\">S\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a pyroptosis v\u00e0 apoptosis \u0111\u1ec1u thu\u1ed9c v\u1ec1 m\u1ed9t c\u00e1ch ch\u1ebft t\u1ebf b\u00e0o, nh\u01b0ng v\u1ec1 c\u01a1 b\u1ea3n ch\u00fang kh\u00e1c nhau. Apoptosis l\u00e0 m\u1ed9t c\u00e1ch ch\u1ebft t\u1ebf b\u00e0o sinh l\u00fd, trong khi pyroptosis th\u01b0\u1eddng li\u00ean quan \u0111\u1ebfn ch\u1ebft t\u1ebf b\u00e0o b\u1ec7nh l\u00fd sau ch\u1ea5n th\u01b0\u01a1ng c\u01a1 th\u1ec3\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib92\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib92\"><span class=\"anchor-text\">[92]<\/span><\/a>. Autophagy l\u00e0 m\u1ed9t lo\u1ea1i hi\u1ec7n t\u01b0\u1ee3ng autophagy t\u1ed3n t\u1ea1i r\u1ed9ng r\u00e3i trong\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 t\u1ebf b\u00e0o nh\u00e2n chu\u1ea9n t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/eukaryotic-cell\">t\u1ebf b\u00e0o nh\u00e2n th\u1ef1c<\/a>. Autophagy th\u01b0\u1eddng \u0111\u01b0\u1ee3c chia th\u00e0nh ba lo\u1ea1i, \u0111\u00f3 l\u00e0 autophagy qua trung gian chaperone, microautophagy v\u00e0 macroautophagy. Hi\u1ec7n nay c\u00f3 r\u1ea5t nhi\u1ec1u nghi\u00ean c\u1ee9u v\u1ec1 macroautophagy\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib93\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib93\"><span class=\"anchor-text\">[93]<\/span><\/a>. Autophagy l\u00e0 m\u1ed9t ph\u1ea7n kh\u00f4ng th\u1ec3 thi\u1ebfu trong qu\u00e1 tr\u00ecnh trao \u0111\u1ed5i ch\u1ea5t b\u00ecnh th\u01b0\u1eddng c\u1ee7a t\u1ebf b\u00e0o. Vi\u1ec7c \u1ee9c ch\u1ebf qu\u00e1 tr\u00ecnh t\u1ef1 th\u1ef1c c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn s\u1ef1 t\u00edch t\u1ee5 c\u00e1c ch\u1ea5t c\u00f3 h\u1ea1i trong c\u00e1c m\u00f4, c\u01a1 quan ho\u1eb7c t\u1ebf b\u00e0o. Vi\u1ec7c k\u00edch ho\u1ea1t qu\u00e1 m\u1ee9c qu\u00e1 tr\u00ecnh autophagy s\u1ebd ph\u00e1 h\u1ee7y c\u00e1c b\u00e0o quan n\u1ed9i b\u00e0o quan tr\u1ecdng v\u00e0 c\u00e1c protein thi\u1ebft y\u1ebfu, g\u00e2y ra apoptosis autophagic\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib94\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib94\"><span class=\"anchor-text\">[94]<\/span><\/a>.<\/p>\n<p id=\"p0080\">Pyroptosis v\u00e0 autophagy c\u00f3 m\u1ed1i li\u00ean h\u1ec7 ch\u1eb7t ch\u1ebd v\u1edbi nhau. Trong nh\u1eefng tr\u01b0\u1eddng h\u1ee3p b\u00ecnh th\u01b0\u1eddng, s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a b\u1ec7nh autophagy v\u00e0 pyroptosis in vivo \u1edf tr\u1ea1ng th\u00e1i c\u00e2n b\u1eb1ng \u0111\u1ed9ng. Khi c\u01a1 th\u1ec3 ph\u1ea3n \u1ee9ng vi\u00eam v\u1edbi c\u00e1c k\u00edch th\u00edch b\u00ean ngo\u00e0i, s\u1ef1 c\u00e2n b\u1eb1ng gi\u1eefa qu\u00e1 tr\u00ecnh t\u1ef1 th\u1ef1c b\u00e0o v\u00e0 b\u1ec7nh pyroptosis b\u1ecb ph\u00e1 v\u1ee1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib95\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib95\"><span class=\"anchor-text\">[95]<\/span><\/a>. V\u00ed d\u1ee5, NF-\u03baB l\u00e0 m\u1ed9t\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 \u0111\u01b0\u1eddng d\u1eabn truy\u1ec1n t\u00edn hi\u1ec7u t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/signal-transduction-pathway\">con \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u<\/a>\u00a0tham gia v\u00e0o vi\u1ec7c truy\u1ec1n t\u00edn hi\u1ec7u c\u1ee7a nhi\u1ec1u\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 \u0111\u01b0\u1eddng d\u1eabn t\u00edn hi\u1ec7u t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-signaling-pathway\">\u0111\u01b0\u1eddng d\u1eabn t\u00edn hi\u1ec7u<\/a>\u00a0\u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c s\u1ef1 truy\u1ec1n t\u00edn hi\u1ec7u. Nghi\u00ean c\u1ee9u cho th\u1ea5y \u1edf chu\u1ed9t IS b\u1ecb lo\u1ea1i b\u1ecf gen NF-\u03baB,\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 mTOR t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mammalian-target-of-rapamycin\">mTOR<\/a>\u00a0ho\u1ea1t \u0111\u1ed9ng b\u1ecb \u1ee9c ch\u1ebf v\u00e0 m\u1ee9c \u0111\u1ed9 autophagy \u0111\u01b0\u1ee3c t\u0103ng c\u01b0\u1eddng. Con \u0111\u01b0\u1eddng k\u00edch ho\u1ea1t t\u00edn hi\u1ec7u c\u1ee7a NF-\u03baB l\u00e0 m\u1ed9t s\u1ed1 l\u01b0\u1ee3ng l\u1edbn c\u00e1c k\u00edch th\u00edch \u0111\u1ec3 k\u00edch ho\u1ea1t c\u00e1c kinase do NF-\u03baB g\u00e2y ra, k\u00edch ho\u1ea1t c\u00e1c b\u1ed9 c\u1eaft I\u03baK\u03b1, I\u03baKB v\u00e0 I\u03baK\u03b3, d\u1eabn \u0111\u1ebfn s\u1ef1 phosphoryl h\u00f3a v\u00e0 suy tho\u00e1i c\u1ee7a I\u03baB, v\u00e0 cu\u1ed1i c\u00f9ng k\u00edch ho\u1ea1t \u0111\u01b0\u1eddng d\u1eabn t\u00edn hi\u1ec7u NF-\u03baB . Sau khi k\u00edch ho\u1ea1t, NF-\u03baB x\u00e2m nh\u1eadp v\u00e0o t\u1ebf b\u00e0o v\u00e0 li\u00ean k\u1ebft \u0111\u1eb7c bi\u1ec7t v\u1edbi th\u1ee5 th\u1ec3 DNA t\u01b0\u01a1ng \u1ee9ng c\u1ee7a n\u00f3, t\u1eeb \u0111\u00f3 k\u00edch th\u00edch s\u1ef1 phi\u00ean m\u00e3 c\u1ee7a c\u00e1c y\u1ebfu t\u1ed1 g\u00e2y vi\u00eam v\u00e0 th\u00fac \u0111\u1ea9y s\u1ef1 bi\u1ec3u hi\u1ec7n m\u1ea1nh m\u1ebd c\u1ee7a c\u00e1c y\u1ebfu t\u1ed1 g\u00e2y vi\u00eam TNF-\u03b1, IL-1\u03b2 v\u00e0 IL-6. C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u NF-\u03baB c\u00f3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh s\u1ef1 k\u00edch ho\u1ea1t m\u1ee9c \u0111\u1ed9 tr\u01b0\u1edbc v\u00e0 sau phi\u00ean m\u00e3 c\u1ee7a protein pyroptotic quan tr\u1ecdng NLRP3 \u0111\u1ec3 g\u00e2y ra b\u1ec7nh pyroptosis. C\u00e1c y\u1ebfu t\u1ed1 g\u00e2y vi\u00eam \u0111\u01b0\u1ee3c bi\u1ec3u hi\u1ec7n nhi\u1ec1u c\u00f3 th\u1ec3 g\u00e2y ra m\u1ed9t \u0111\u1ee3t vi\u00eam trong c\u01a1 th\u1ec3, g\u00e2y ra b\u1ec7nh pyroptosis v\u00e0 m\u1edf r\u1ed9ng h\u01a1n n\u1eefa ph\u1ea3n \u1ee9ng vi\u00eam, do \u0111\u00f3 l\u00e0m n\u1eb7ng th\u00eam t\u1ed5n th\u01b0\u01a1ng n\u00e3o.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib96\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib96\"><span class=\"anchor-text\">[96]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib97\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib97\"><span class=\"anchor-text\">[97]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib98\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib98\"><span class=\"anchor-text\">[98]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0050\">\n<h3 id=\"sect0070\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.5. C\u01a1 ch\u1ebf g\u00e2y pyroptosis v\u00e0 vi\u00eam li\u00ean quan \u0111\u1ebfn IS<\/h3>\n<p id=\"p0085\">C\u00e1c t\u1ea7ng vi\u00eam t\u1ed3n t\u1ea1i \u1edf c\u00e1c giai \u0111o\u1ea1n kh\u00e1c nhau c\u1ee7a IS\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib99\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib99\"><span class=\"anchor-text\">[99]<\/span><\/a>. Trong giai \u0111o\u1ea1n \u0111\u1ea7u c\u1ee7a IS, l\u01b0u l\u01b0\u1ee3ng m\u00e1u trong n\u00e3o ch\u1eadm l\u1ea1i v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 b\u1ea1ch c\u1ea7u trung t\u00ednh t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neutrophil\">b\u1ea1ch c\u1ea7u trung t\u00ednh<\/a>\u00a0tu\u00e2n th\u1ee7\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c t\u1ebf b\u00e0o n\u1ed9i m\u00f4 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/endothelial-cell\">t\u1ebf b\u00e0o n\u1ed9i m\u00f4<\/a>\u00a0m\u1ea1ch m\u00e1u thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 v\u00e0 ph\u1ea3n \u1ee9ng vi\u00eam c\u1ea5p t\u00ednh ban \u0111\u1ea7u b\u1eaft \u0111\u1ea7u\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib100\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib100\"><span class=\"anchor-text\">[100]<\/span><\/a>. V\u1edbi s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a t\u00e1i t\u01b0\u1edbi m\u00e1u sau thi\u1ebfu m\u00e1u n\u00e3o, c\u00e1c y\u1ebfu t\u1ed1 vi\u00eam ngo\u1ea1i sinh, t\u1ebf b\u00e0o vi\u00eam v\u00e0 c\u00e1c y\u1ebfu t\u1ed1 vi\u00eam \u0111i qua h\u00e0ng r\u00e0o m\u00e1u n\u00e3o, d\u1eabn \u0111\u1ebfn h\u1eadu qu\u1ea3 th\u1ee9 ph\u00e1t l\u00e0 thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 sau t\u00e1i t\u01b0\u1edbi m\u00e1u, d\u1eabn \u0111\u1ebfn gi\u1ea3i ph\u00f3ng m\u1ed9t s\u1ed1 l\u01b0\u1ee3ng l\u1edbn c\u00e1c y\u1ebfu t\u1ed1 oxy h\u00f3a v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c g\u1ed1c t\u1ef1 do t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/radical-chemistry\">g\u1ed1c t\u1ef1 do<\/a>. V\u00e0o th\u1eddi \u0111i\u1ec3m n\u00e0y, microglia trong\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 m\u00f4 n\u00e3o t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-tissue\">m\u00f4 n\u00e3o<\/a>\u00a0d\u1ea7n d\u1ea7n \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t v\u1edbi s\u1ed1 l\u01b0\u1ee3ng l\u1edbn v\u00e0 s\u1ea3n xu\u1ea5t nhi\u1ec1u h\u01a1n\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c ch\u1ea5t trung gian g\u00e2y vi\u00eam t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammatory-mediator\">C\u00e1c trung gian g\u00e2y vi\u00eam<\/a>. Lo\u1ea1i ch\u1ea5t trung gian g\u00e2y vi\u00eam n\u00e0y c\u00f3 th\u1ec3 k\u00edch ho\u1ea1t qu\u00e1 m\u1ee9c c\u00e1c t\u1ebf b\u00e0o n\u1ed9i m\u00f4 trong m\u00f4 n\u00e3o v\u00e0 t\u1ea1o ra m\u1ed9t l\u01b0\u1ee3ng l\u1edbn\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 y\u1ebfu t\u1ed1 m\u00f4 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/thromboplastin\">y\u1ebfu t\u1ed1 m\u00f4<\/a>\u00a0t\u00edch l\u0169y \u0111\u1ed9c t\u00ednh c\u1ee7a axit amin. \u0110i\u1ec1u n\u00e0y c\u00e0ng l\u00e0m tr\u1ea7m tr\u1ecdng th\u00eam vi\u1ec7c gi\u1ea3i ph\u00f3ng c\u00e1c y\u1ebfu t\u1ed1 oxy h\u00f3a, c\u00e1c g\u1ed1c t\u1ef1 do v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 carbon monoxide t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/carbon-monoxide\">cacbon monoxit<\/a>v\u00e0 k\u00edch ho\u1ea1t c\u00e1c \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u li\u00ean quan \u0111\u1ebfn ph\u1ea3n \u1ee9ng vi\u00eam nh\u01b0 NF-\u03baB, th\u1ee5 th\u1ec3 gi\u1ed1ng Toll v\u00e0 th\u1ee5 th\u1ec3 gi\u1ed1ng Nod (NLR)\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib101\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib101\"><span class=\"anchor-text\">[101]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib102\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib102\"><span class=\"anchor-text\">[102]<\/span><\/a>. V\u00ed d\u1ee5, NLR, c\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng c\u00f3 23 th\u00e0nh vi\u00ean trong h\u1ecd NLR, ch\u00fang ch\u1ee7 y\u1ebfu bi\u1ec3u hi\u1ec7n \u1edf t\u1ebf b\u00e0o ch\u1ea5t c\u1ee7a t\u1ebf b\u00e0o v\u00e0 \u0111\u00f3ng vai tr\u00f2 ch\u00ednh trong ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch b\u1ea9m sinh c\u1ee7a c\u01a1 th\u1ec3. C\u00e1c th\u00e0nh vi\u00ean c\u1ee7a gia \u0111\u00ecnh NLR, Nalp1, Nalp3, Nalp5 v\u00e0 Ipaf, c\u00f3 th\u1ec3 k\u00edch ho\u1ea1t k\u00edch ho\u1ea1t caspase-1 th\u00f4ng qua\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 protein b\u1ed9 chuy\u1ec3n \u0111\u1ed5i t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/adaptor-protein\">b\u1ed9 chuy\u1ec3n \u0111\u1ed5i protein<\/a>\u00a0ASC, b\u1eaft \u0111\u1ea7u m\u1ed9t lo\u1ea1t c\u00e1c ph\u1ea3n \u1ee9ng vi\u00eam v\u00e0 l\u00e0m trung gian ch\u1ee9ng pyroptosis\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib103\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib103\"><span class=\"anchor-text\">[103]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib104\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib104\"><span class=\"anchor-text\">[104]<\/span><\/a>. NLRP3 l\u00e0 th\u00e0nh ph\u1ea7n quan tr\u1ecdng c\u1ee7a c\u00e1c y\u1ebfu t\u1ed1 g\u00e2y vi\u00eam. NLRP3 ch\u1ee9a ba mi\u1ec1n: PYD, NACHT v\u00e0 LRR, c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c bi\u1ec3u th\u1ecb b\u1eb1ng LRR-NACHT-PYD: PYD-CARD: CARD-CARDC m\u1ed9t mi\u1ec1n spase. N\u00f3 ph\u1ea3n \u1ee9ng v\u1edbi c\u00e1c t\u00edn hi\u1ec7u kh\u00e1c nhau c\u1ee7a t\u1ed5n th\u01b0\u01a1ng n\u1ed9i sinh, do \u0111\u00f3, vi\u1ec7c k\u00edch ho\u1ea1t d\u00f2ng si\u00eau nh\u1ecf NLRP3 \u0111\u01b0\u1ee3c coi l\u00e0 lo\u1ea1i b\u1ec7nh pyroptosis ch\u00ednh\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib105\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib105\"><span class=\"anchor-text\">[105]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib106\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib106\"><span class=\"anchor-text\">[106]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib107\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib107\"><span class=\"anchor-text\">[107]<\/span><\/a>.<\/p>\n<p id=\"p0090\">Inflammasome l\u00e0 c\u00e1c ph\u1ee9c h\u1ee3p protein \u0111\u01b0\u1ee3c t\u1eadp h\u1ee3p sau khi c\u01a1 th\u1ec3 nh\u1eadn \u0111\u01b0\u1ee3c t\u00edn hi\u1ec7u nhi\u1ec5m tr\u00f9ng ho\u1eb7c t\u1ed5n th\u01b0\u01a1ng t\u1ebf b\u00e0o v\u00e0 \u0111\u00f3ng vai tr\u00f2 l\u00e0 n\u1ec1n t\u1ea3ng cho vi\u1ec7c tuy\u1ec3n d\u1ee5ng v\u00e0 k\u00edch ho\u1ea1t pro-caspase-1. Protein kh\u1edfi \u0111\u1ed9ng NLRP3 c\u00f3 th\u1ec3 huy \u0111\u1ed9ng m\u1ed9t l\u01b0\u1ee3ng l\u1edbn Procaspase-1 th\u00f4ng qua qu\u00e1 tr\u00ecnh oligome h\u00f3a b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng ph\u00e2n t\u1eed ti\u1ebfp h\u1ee3p h\u1ed3ng c\u1ea7u ASC\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib108\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib108\"><span class=\"anchor-text\">[108]<\/span><\/a>. Procaspase-1 l\u00e0 ti\u1ec1n th\u00e2n c\u1ee7a caspase-1, v\u00e0 caspase-1 ho\u1ea1t \u0111\u1ed9ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m ly gi\u1ea3i nhanh c\u00e1c t\u1ebf b\u00e0o \u0111\u1ec3 k\u00edch ho\u1ea1t v\u00e0 gi\u1ea3i ph\u00f3ng IL-1\u03b2 v\u00e0 IL-18 ngo\u1ea1i b\u00e0o, \u0111i\u1ec1u n\u00e0y c\u00e0ng l\u00e0m tr\u1ea7m tr\u1ecdng th\u00eam ph\u1ea3n \u1ee9ng vi\u00eam. Do \u0111\u00f3, s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a b\u1ec7nh pyroptosis c\u00f3 li\u00ean quan ch\u1eb7t ch\u1ebd \u0111\u1ebfn s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a ph\u1ea3n \u1ee9ng vi\u00eam v\u00e0 s\u1ef1 h\u00ecnh th\u00e0nh c\u00e1c d\u00f2ng si\u00eau nh\u1ecf. S\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a t\u1ed5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 n\u00e3o c\u00f3 li\u00ean quan ch\u1eb7t ch\u1ebd h\u01a1n \u0111\u1ebfn s\u1ef1 t\u01b0\u01a1ng t\u00e1c gi\u1eefa ch\u1ee9ng pyroptosis v\u00e0 ph\u1ea3n \u1ee9ng vi\u00eam\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib109\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib109\"><span class=\"anchor-text\">[109]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib110\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib110\"><span class=\"anchor-text\">[110]<\/span><\/a>. \u0110\u1eb7c bi\u1ec7t l\u00e0 trong h\u1ec7 th\u1ed1ng th\u1ea7n kinh trung \u01b0\u01a1ng, t\u1ebf b\u00e0o h\u00ecnh sao k\u00edch ho\u1ea1t v\u00e0 t\u0103ng sinh microglia v\u00e0 t\u1ea1o ra m\u1ed9t s\u1ed1 l\u01b0\u1ee3ng l\u1edbn c\u00e1c ch\u1ea5t trung gian g\u00e2y vi\u00eam. Nh\u1eefng ch\u1ea5t trung gian g\u00e2y vi\u00eam n\u00e0y c\u00f3 th\u1ec3 k\u00edch ho\u1ea1t c\u00e1c t\u1ebf b\u00e0o n\u1ed9i m\u00f4 \u0111\u1ec3 t\u1ea1o ra nhi\u1ec1u lo\u1ea1i y\u1ebfu t\u1ed1 m\u00f4, l\u00e0m t\u0103ng \u0111\u1ed9c t\u00ednh c\u1ee7a\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c axit amin k\u00edch th\u00edch t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/excitatory-amino-acid\">axit amin k\u00edch th\u00edch<\/a>v\u00e0 th\u00fac \u0111\u1ea9y vi\u1ec7c ph\u00e1t h\u00e0nh\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 oxit nitric t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nitric-oxide\">oxit nitric<\/a>\u00a0v\u00e0 c\u00e1c g\u1ed1c t\u1ef1 do oxy. C\u00e1c ch\u1ea5t tr\u00ean c\u00f2n d\u1eabn \u0111\u1ebfn vi\u1ec7c k\u00edch ho\u1ea1t nhi\u1ec1u \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u vi\u00eam nh\u01b0 NF-\u03baB v\u00e0 JNK2\/STAT3, \u0111\u1ed3ng th\u1eddi th\u00fac \u0111\u1ea9y s\u1ef1 t\u1eadp h\u1ee3p c\u00e1c d\u00f2ng si\u00eau nh\u1ecf nh\u01b0 NLRP1 v\u00e0 NLRP3. Caspase-1 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t g\u00e2y ra hi\u1ec7n t\u01b0\u1ee3ng pyroptosis c\u1ee7a t\u1ebf b\u00e0o, m\u1edf r\u1ed9ng ph\u1ea3n \u1ee9ng vi\u00eam v\u00e0 l\u00e0m n\u1eb7ng th\u00eam t\u1ed5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 n\u00e3o\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib111\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib111\"><span class=\"anchor-text\">[111]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib112\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib112\"><span class=\"anchor-text\">[112]<\/span><\/a>. M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng so v\u1edbi chu\u1ed9t hoang d\u00e3, n\u1ed3ng \u0111\u1ed9 AIM2 v\u00e0 IL-1\u03b2 trong n\u00e3o c\u1ee7a AIM2\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 chu\u1ed9t b\u1ecb lo\u1ea1i t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/knockout-mouse\">h\u1ea1 g\u1ee5c chu\u1ed9t<\/a>\u00a0sau khi t\u00e1i t\u01b0\u1edbi m\u00e1u n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 gi\u1ea3m \u0111\u00e1ng k\u1ec3, th\u1ec3 t\u00edch v\u00f9ng nh\u1ed3i m\u00e1u gi\u1ea3m \u0111\u00e1ng k\u1ec3 v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 ch\u1ee9c n\u0103ng th\u1ea7n kinh t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nervous-system-physiology\">ch\u1ee9c n\u0103ng th\u1ea7n kinh<\/a>\u00a0\u0111i\u1ec3m s\u1ed1 c\u0169ng \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n \u0111\u00e1ng k\u1ec3. Vi\u1ec7c \u1ee9c ch\u1ebf k\u00edch ho\u1ea1t h\u1ed3ng c\u1ea7u AIM2 c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a b\u1ec7nh pyroptosis \u1edf m\u1ed9t m\u1ee9c \u0111\u1ed9 nh\u1ea5t \u0111\u1ecbnh, do \u0111\u00f3 l\u00e0m gi\u1ea3m ch\u1ea5n th\u01b0\u01a1ng n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib113\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib113\"><span class=\"anchor-text\">[113]<\/span><\/a>. V\u00ec v\u1eady, pyroptosis \u0111\u00f3ng m\u1ed9t vai tr\u00f2 quan tr\u1ecdng trong qu\u00e1 tr\u00ecnh ch\u1ea5n th\u01b0\u01a1ng do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 - t\u00e1i t\u01b0\u1edbi m\u00e1u n\u00e3o. Inflammasome NLRP3 l\u00e0 m\u1ed9t protein quan tr\u1ecdng trong con \u0111\u01b0\u1eddng pyroptotic v\u00e0 vi\u1ec7c \u1ee9c ch\u1ebf bi\u1ec3u hi\u1ec7n c\u1ee7a n\u00f3 c\u00f3 th\u1ec3 \u0111\u1ed3ng th\u1eddi \u1ee9c ch\u1ebf s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a c\u00e1c protein li\u00ean quan \u0111\u1ebfn con \u0111\u01b0\u1eddng pyroptotic \u1edf h\u1ea1 l\u01b0u, h\u1ea1n ch\u1ebf ph\u1ea3n \u1ee9ng vi\u00eam v\u00e0 l\u00e0m gi\u1ea3m t\u1ed5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 n\u00e3o.<\/p>\n<\/section>\n<section id=\"sec0055\">\n<h3 id=\"sect0075\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.6. B\u1ec7nh pyroptosis v\u00e0 t\u1ed5n th\u01b0\u01a1ng ty th\u1ec3 l\u00e0m trung gian cho t\u1ed5n th\u01b0\u01a1ng do stress oxy h\u00f3a sau IS<\/h3>\n<p id=\"p0095\">Ty th\u1ec3 ch\u1ee7 y\u1ebfu tham gia v\u00e0o qu\u00e1 tr\u00ecnh h\u00f4 h\u1ea5p hi\u1ebfu kh\u00ed c\u1ee7a t\u1ebf b\u00e0o v\u00e0 l\u00e0 n\u01a1i di\u1ec5n ra qu\u00e1 tr\u00ecnh h\u00f4 h\u1ea5p hi\u1ebfu kh\u00ed. Ty th\u1ec3 cung c\u1ea5p c\u01a1 s\u1edf ion h\u00f3a \u0111\u1ec3 truy\u1ec1n t\u00edn hi\u1ec7u b\u00ecnh th\u01b0\u1eddng gi\u1eefa c\u00e1c t\u1ebf b\u00e0o v\u00e0 truy\u1ec1n t\u00edn hi\u1ec7u c\u1ee7a t\u1ebf b\u00e0o th\u1ea7n kinh\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib114\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib114\"><span class=\"anchor-text\">[114]<\/span><\/a>. T\u1ed5n th\u01b0\u01a1ng ty th\u1ec3 ch\u1ee7 y\u1ebfu l\u00e0 do b\u1ea5t th\u01b0\u1eddng\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 qu\u00e1 tr\u00ecnh trao \u0111\u1ed5i ch\u1ea5t c\u1ee7a ty th\u1ec3 t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitochondrial-respiration\">chuy\u1ec3n h\u00f3a ty th\u1ec3<\/a>\u00a0v\u00e0 t\u1ed5n th\u01b0\u01a1ng oxy h\u00f3a\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib115\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib115\"><span class=\"anchor-text\">[115]<\/span><\/a>. C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng t\u1ed5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 n\u00e3o c\u00f3 li\u00ean quan ch\u1eb7t ch\u1ebd \u0111\u1ebfn r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng ty th\u1ec3\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib116\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib116\"><span class=\"anchor-text\">[116]<\/span><\/a>. C\u0103ng th\u1eb3ng oxy h\u00f3a, l\u00e0 ch\u00eca kh\u00f3a d\u1eabn \u0111\u1ebfn s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a t\u1ed5n th\u01b0\u01a1ng oxy h\u00f3a, c\u00f3 li\u00ean quan ch\u1eb7t ch\u1ebd \u0111\u1ebfn ch\u1ee9ng pyroptosis\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib117\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib117\"><span class=\"anchor-text\">[117]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib118\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib118\"><span class=\"anchor-text\">[118]<\/span><\/a>. C\u0103ng th\u1eb3ng oxy h\u00f3a c\u00f3 nhi\u1ec1u kh\u1ea3 n\u0103ng \u0111\u01b0\u1ee3c bi\u1ec3u hi\u1ec7n trong t\u1ed5n th\u01b0\u01a1ng m\u00f4 n\u00e3o, \u0111\u1eb7c bi\u1ec7t l\u00e0 trong thi\u1ebfu m\u00e1u n\u00e3o v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 ch\u1ea5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/reperfusion-injury\">ch\u1ea5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u<\/a>\u00a0sau thi\u1ebfu m\u00e1u n\u00e3o\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib119\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib119\"><span class=\"anchor-text\">[119]<\/span><\/a>. Khi c\u01a1 th\u1ec3 b\u1ecb t\u1ea5n c\u00f4ng b\u1edfi c\u00e1c ch\u1ea5t \u0111\u1ed9c h\u1ea1i b\u00ean ngo\u00e0i, t\u1ebf b\u00e0o c\u00f3 th\u1ec3 ti\u1ebft ra m\u1ed9t l\u01b0\u1ee3ng l\u1edbn\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 ROS t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/reactive-oxygen-species\">ROS<\/a>\u00a0V\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 than ho\u1ea1t t\u00ednh t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/activated-charcoal\">than ho\u1ea1t t\u00ednh<\/a>, ph\u00e1 v\u1ee1 s\u1ef1 c\u00e2n b\u1eb1ng gi\u1eefa qu\u00e1 tr\u00ecnh oxy h\u00f3a v\u00e0 ch\u1ed1ng oxy h\u00f3a, d\u1eabn \u0111\u1ebfn m\u1ed9t lo\u1ea1t c\u00e1c ph\u1ea3n \u1ee9ng ph\u00e1 h\u1ee7y oxy h\u00f3a\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib120\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib120\"><span class=\"anchor-text\">[120]<\/span><\/a>. H\u1ea7u h\u1ebft ROS \u0111\u01b0\u1ee3c ti\u1ebft ra b\u1edfi ty th\u1ec3\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib121\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib121\"><span class=\"anchor-text\">[121]<\/span><\/a>. Khi b\u1ecb k\u00edch th\u00edch b\u1edfi c\u00e1c k\u00edch th\u00edch b\u00ean ngo\u00e0i ho\u1eb7c x\u1ea3y ra t\u1ed5n th\u01b0\u01a1ng n\u1ed9i sinh, c\u01a1 th\u1ec3 s\u1ebd k\u00edch th\u00edch s\u1ef1 li\u00ean k\u1ebft c\u1ee7a nucleotide v\u1edbi NLRP3 b\u1eb1ng c\u00e1ch t\u1ea1o ra n\u1ed3ng \u0111\u1ed9 ROS cao, k\u00edch ho\u1ea1t ph\u1ee9c h\u1ee3p protein h\u1ed3ng c\u1ea7u. Khi ROS b\u1ecb k\u00edch ho\u1ea1t qu\u00e1 m\u1ee9c, tr\u1eadt t\u1ef1 b\u00ecnh th\u01b0\u1eddng c\u1ee7a c\u00e1c \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u trong c\u01a1 th\u1ec3 b\u1ecb gi\u00e1n \u0111o\u1ea1n, d\u1eabn \u0111\u1ebfn s\u1ef1 ph\u00e1 h\u1ee7y v\u1eadt li\u1ec7u di truy\u1ec1n, protein v\u00e0 c\u00e1c b\u00e0o quan kh\u00e1c nhau (bao g\u1ed3m c\u1ea3 ty th\u1ec3) trong t\u1ebf b\u00e0o. Khi c\u00e1c b\u00e0o quan kh\u00e1c nhau nh\u01b0 ty th\u1ec3 trong t\u1ebf b\u00e0o b\u1ecb t\u1ed5n th\u01b0\u01a1ng, t\u1ebf b\u00e0o c\u00f3 ch\u1ebf \u0111\u1ed9 dinh d\u01b0\u1ee1ng v\u00e0 trao \u0111\u1ed5i ch\u1ea5t b\u1ea5t th\u01b0\u1eddng, v\u00e0 ROS c\u00f3 th\u1ec3 l\u00e0m n\u1eb7ng th\u00eam t\u00ecnh tr\u1ea1ng t\u1ed5n th\u01b0\u01a1ng c\u1ee7a t\u1ebf b\u00e0o.\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 n\u1ed9i m\u00f4 m\u1ea1ch m\u00e1u t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascular-endothelium\">n\u1ed9i m\u1ea1c m\u1ea1ch m\u00e1u<\/a>\u00a0v\u00e0 g\u00e2y ra s\u1ef1 x\u00e1o tr\u1ed9n c\u1ee7a\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 vi tu\u1ea7n ho\u00e0n t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microcirculation\">vi tu\u1ea7n ho\u00e0n<\/a>\u00a0trong n\u00e3o. S\u1ef1 r\u1ed1i lo\u1ea1n t\u00ednh th\u1ea5m c\u1ee7a h\u00e0ng r\u00e0o m\u00e1u n\u00e3o trong n\u00e3o g\u00e2y ra s\u1ef1 bi\u1ec3u hi\u1ec7n qu\u00e1 m\u1ee9c c\u1ee7a\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c ph\u00e2n t\u1eed k\u1ebft d\u00ednh t\u1ebf b\u00e0o t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-adhesion-molecule\">ph\u00e2n t\u1eed k\u1ebft d\u00ednh t\u1ebf b\u00e0o<\/a>, t\u1eeb \u0111\u00f3 l\u00e0m n\u1eb7ng th\u00eam ch\u1ea5n th\u01b0\u01a1ng s\u1ecd n\u00e3o\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib122\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib122\"><span class=\"anchor-text\">[122]<\/span><\/a>. Trong khi \u0111\u00f3,\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 stress oxy h\u00f3a t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/oxidative-stress\">c\u0103ng th\u1eb3ng oxy h\u00f3a<\/a>\u00a0l\u00e0m cho c\u00e1c t\u1ebf b\u00e0o d\u1ea7n d\u1ea7n bi\u1ec3u hi\u1ec7n ch\u1ebf \u0111\u1ed9 ch\u1ebft t\u1ebf b\u00e0o, \u0111\u1eb7c tr\u01b0ng b\u1edfi s\u1ef1 gia t\u0103ng\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 t\u00ednh th\u1ea5m c\u1ee7a m\u00e0ng t\u1ebf b\u00e0o t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-membrane-permeability\">t\u00ednh th\u1ea5m c\u1ee7a m\u00e0ng t\u1ebf b\u00e0o<\/a>\u00a0v\u00e0 gi\u1ea3i ph\u00f3ng n\u1ed9i dung t\u1ebf b\u00e0o - pyroptosis\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib120\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib120\"><span class=\"anchor-text\">[120]<\/span><\/a>. Do \u0111\u00f3, c\u1ea3 b\u1ec7nh pyroptosis v\u00e0 t\u1ed5n th\u01b0\u01a1ng ty th\u1ec3 \u0111\u1ec1u li\u00ean quan \u0111\u1ebfn qu\u00e1 tr\u00ecnh b\u1ec7nh l\u00fd c\u1ee7a ch\u1ea5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 n\u00e3o. Ng\u01b0\u1eddi ta \u0111\u00e3 b\u00e1o c\u00e1o r\u1eb1ng protein li\u00ean quan \u0111\u1ebfn s\u1ef1 v\u1eadn \u0111\u1ed9ng c\u1ee7a ty th\u1ec3 Drp1 l\u00e0 protein quan tr\u1ecdng c\u1ea7n thi\u1ebft \u0111\u1ec3 ty th\u1ec3 duy tr\u00ec c\u00e1c ch\u1ee9c n\u0103ng sinh l\u00fd b\u00ecnh th\u01b0\u1eddng.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib123\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib123\"><span class=\"anchor-text\">[123]<\/span><\/a>. Khi m\u1ee9c \u0111\u1ed9 bi\u1ec3u hi\u1ec7n c\u1ee7a Drp1 t\u0103ng l\u00ean, n\u00f3 c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 qu\u00e1 tr\u00ecnh ph\u00e2n h\u1ea1ch ty th\u1ec3 t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitochondrial-fission\">s\u1ef1 ph\u00e2n h\u1ea1ch c\u1ee7a ty th\u1ec3<\/a>\u00a0x\u1eed l\u00fd v\u00e0 gi\u1ea3m m\u1ee9c \u0111\u1ed9 pyroptosis, do \u0111\u00f3 l\u00e0m ch\u1eadm s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a thi\u1ec7t h\u1ea1i\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib124\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib124\"><span class=\"anchor-text\">[124]<\/span><\/a>. Khi c\u01a1 th\u1ec3 nh\u1eadn \u0111\u01b0\u1ee3c nhi\u1ec1u lo\u1ea1i k\u00edch th\u00edch g\u00e2y t\u1ed5n th\u01b0\u01a1ng n\u1ed9i sinh v\u00e0 ngo\u1ea1i sinh, qu\u00e1 tr\u00ecnh \u0111i\u1ec1u ch\u1ec9nh c\u00e1c \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u trong c\u01a1 th\u1ec3 s\u1ebd thay \u0111\u1ed5i. N\u00f3 \u0111\u01b0\u1ee3c bi\u1ec3u hi\u1ec7n b\u1eb1ng vi\u1ec7c gi\u1ea3m b\u00e0i ti\u1ebft Drp1, t\u1ed5n th\u01b0\u01a1ng ty th\u1ec3, r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng ty th\u1ec3 v\u00e0 t\u0103ng apoptosis v\u00e0 pyroptosis, d\u1eabn \u0111\u1ebfn c\u00e1c b\u1ec7nh kh\u00e1c nhau trong c\u01a1 th\u1ec3\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib125\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib125\"><span class=\"anchor-text\">[125]<\/span><\/a>. C\u00e1c nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y cho th\u1ea5y r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng ty th\u1ec3 g\u00e2y ra s\u1ef1 k\u00edch ho\u1ea1t h\u1ed3ng c\u1ea7u NLRP3 trong ch\u1ea5n th\u01b0\u01a1ng do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 \/ t\u00e1i t\u01b0\u1edbi m\u00e1u n\u00e3o\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib126\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib126\"><span class=\"anchor-text\">[126]<\/span><\/a>. ty th\u1ec3\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 vi\u1ec7c t\u00e1ch protein 2 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/uncoupling-protein-2\">t\u00e1ch protein 2<\/a>\u00a0(UCP2) l\u00e0m tr\u1ea7m tr\u1ecdng th\u00eam t\u1ed5n th\u01b0\u01a1ng n\u00e3o sau CIRI, v\u00e0 c\u00e1c nghi\u00ean c\u1ee9u m\u1edbi cho th\u1ea5y s\u1ef1 thi\u1ebfu h\u1ee5t UCP2 gi\u00fap t\u0103ng c\u01b0\u1eddng k\u00edch ho\u1ea1t h\u1ed3ng c\u1ea7u NLRP3 sau khi l\u00e0m tr\u1ea7m tr\u1ecdng th\u00eam CIRI do t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft trong \u1ed1ng nghi\u1ec7m v\u00e0 in vivo. UCP2 c\u00f3 th\u1ec3 l\u00e0 m\u1ee5c ti\u00eau \u0111i\u1ec1u tr\u1ecb ti\u1ec1m n\u0103ng cho t\u00ecnh tr\u1ea1ng CIRI x\u1ea5u \u0111i do t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft. S\u1ef1 thi\u1ebfu h\u1ee5t UCP2 c\u0169ng t\u0103ng c\u01b0\u1eddng k\u00edch ho\u1ea1t h\u1ed3ng c\u1ea7u NLRP3 v\u00e0 s\u1ea3n xu\u1ea5t ROS trong t\u1ebf b\u00e0o th\u1ea7n kinh in vitro v\u00e0 in vivo\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib127\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib127\"><span class=\"anchor-text\">[127]<\/span><\/a>.\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Adiponectin t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/adiponectin\">Adiponectin<\/a>\u00a0l\u00e0 m\u1ed9t lo\u1ea1i hormone c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb m\u1ee1 v\u1edbi t\u00e1c d\u1ee5ng ch\u1ed1ng oxy h\u00f3a v\u00e0 ch\u1ed1ng vi\u00eam r\u1ed9ng r\u00e3i. Adiponectin peptide l\u00e0m gi\u1ea3m c\u0103ng th\u1eb3ng oxy h\u00f3a v\u00e0 k\u00edch ho\u1ea1t h\u1ed3ng c\u1ea7u NLRP3 sau ch\u1ea5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 n\u00e3o b\u1eb1ng c\u00e1ch \u0111i\u1ec1u ch\u1ec9nh AMPK \/ GSK-3\u03b2\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib128\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib128\"><span class=\"anchor-text\">[128]<\/span><\/a>. Do \u0111\u00f3, trong IS, c\u00f3 m\u1ed1i quan h\u1ec7 ch\u1eb7t ch\u1ebd gi\u1eefa s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a b\u1ec7nh pyroptosis v\u00e0 t\u1ed5n th\u01b0\u01a1ng ty th\u1ec3 v\u00e0 c\u00f3 s\u1ef1 t\u01b0\u01a1ng t\u00e1c ch\u1eb7t ch\u1ebd gi\u1eefa hai \u0111i\u1ec1u n\u00e0y.<\/p>\n<\/section>\n<section id=\"sec0060\">\n<h3 id=\"sect0080\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.7. C\u0103ng th\u1eb3ng oxy h\u00f3a\/c\u0103ng th\u1eb3ng nitro h\u00f3a l\u00e0m trung gian cho ch\u1ee9ng pyroptosis sau IS<\/h3>\n<p id=\"p0100\">C\u0103ng th\u1eb3ng oxy h\u00f3a \/ nitro h\u00f3a v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 t\u00ecnh tr\u1ea1ng vi\u00eam th\u1ea7n kinh t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroinflammation\">vi\u00eam d\u00e2y th\u1ea7n kinh<\/a>\u00a0l\u00e0 ch\u00eca kh\u00f3a\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c qu\u00e1 tr\u00ecnh b\u1ec7nh l\u00fd t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathological-process\">qu\u00e1 tr\u00ecnh b\u1ec7nh l\u00fd<\/a>\u00a0c\u1ee7a ch\u1ea5n th\u01b0\u01a1ng do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9-t\u00e1i t\u01b0\u1edbi m\u00e1u n\u00e3o, t\u1ed5n th\u01b0\u01a1ng t\u1ebf b\u00e0o th\u1ea7n kinh trung gian, t\u1ed5n th\u01b0\u01a1ng h\u00e0ng r\u00e0o m\u00e1u n\u00e3o v\u00e0 chuy\u1ec3n d\u1ea1ng xu\u1ea5t huy\u1ebft trong \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib129\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib129\"><span class=\"anchor-text\">[129]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib130\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib130\"><span class=\"anchor-text\">[130]<\/span><\/a>. Oxit nitric (NO) v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 peroxynitrite t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/peroxynitrite\">peroxynitrit<\/a>\u00a0(ONOO-) l\u00e0 c\u00e1c RNS \u0111i\u1ec3n h\u00ecnh trong CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib130\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib130\"><span class=\"anchor-text\">[130]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib131\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib131\"><span class=\"anchor-text\">[131]<\/span><\/a>. C\u00f3 3 \u0111\u1ed3ng ph\u00e2n c\u1ee7a\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 nitric oxit t\u1ed5ng h\u1ee3p t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nitric-oxide-synthase\">t\u1ed5ng h\u1ee3p oxit nitric<\/a>:\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 enzyme t\u1ed5ng h\u1ee3p oxit nitric n\u1ed9i m\u00f4 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/endothelial-nitric-oxide-synthase\">t\u1ed5ng h\u1ee3p oxit nitric n\u1ed9i m\u00f4<\/a>\u00a0(eNOS) t\u1ea1o ra n\u1ed3ng \u0111\u1ed9 NO th\u1ea5p v\u00e0 c\u00f3 ch\u1ee9c n\u0103ng sinh l\u00fd; trong khi\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 enzyme t\u1ed5ng h\u1ee3p oxit nitric t\u1ebf b\u00e0o th\u1ea7n kinh t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuronal-nitric-oxide-synthase\">t\u1ed5ng h\u1ee3p oxit nitric t\u1ebf b\u00e0o th\u1ea7n kinh<\/a>\u00a0(nNOS) v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 enzyme t\u1ed5ng h\u1ee3p oxit c\u1ea3m \u1ee9ng t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inducible-nitric-oxide-synthase\">t\u1ed5ng h\u1ee3p oxit nitric c\u1ea3m \u1ee9ng<\/a>\u00a0(iNOS) t\u1ea1o ra n\u1ed3ng \u0111\u1ed9 NO cao, g\u00e2y vi\u00eam v\u00e0 t\u0103ng t\u00ednh th\u1ea5m c\u1ee7a h\u00e0ng r\u00e0o m\u00e1u n\u00e3o\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib132\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib132\"><span class=\"anchor-text\">[132]<\/span><\/a>. Vi\u1ec7c s\u1ea3n xu\u1ea5t qu\u00e1 m\u1ee9c ROS\/RNS t\u1ea1o ra m\u1ed9t m\u00f4i tr\u01b0\u1eddng vi m\u00f4 c\u0103ng th\u1eb3ng v\u00e0 d\u1eabn \u0111\u1ebfn m\u1ed9t lo\u1ea1t c\u00e1c t\u1ea7ng t\u00edn hi\u1ec7u t\u1ebf b\u00e0o, d\u1eabn \u0111\u1ebfn t\u00ecnh tr\u1ea1ng vi\u00eam, t\u0103ng t\u00ednh th\u1ea5m c\u1ee7a h\u00e0ng r\u00e0o m\u00e1u n\u00e3o,\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 ch\u1ee9ng ph\u00f9 n\u00e3o t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-edema\">ph\u00f9 n\u00e3o<\/a>\u00a0v\u00e0 c\u00e1i ch\u1ebft c\u1ee7a t\u1ebf b\u00e0o th\u1ea7n kinh\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib133\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib133\"><span class=\"anchor-text\">[133]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib134\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib134\"><span class=\"anchor-text\">[134]<\/span><\/a>. Peroxynitrit trung gian\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 chu\u1ed7i DNA t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/dna-strand\">s\u1ee3i DNA<\/a>\u00a0ph\u00e1 v\u1ee1 v\u00e0 k\u00edch ho\u1ea1t\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 ribozyme t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ribozyme\">ribozyme<\/a>\u00a0poly(ADP-ribose) synthase (PARS), c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 poly(ADP-ribose) polymerase (PARP) ho\u1eb7c poly(ADPribose)\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 transferase t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/transferase\">ch\u1ea5t chuy\u1ec3n h\u00f3a<\/a>\u00a0(pADPRT). ONOO- c\u00f3 th\u1ec3 k\u00edch ho\u1ea1t tr\u1ef1c ti\u1ebfp PARP\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib135\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib135\"><span class=\"anchor-text\">[135]<\/span><\/a>, v\u00e0 c\u00e1c th\u00ed nghi\u1ec7m in vivo v\u00e0 in vitro \u0111\u00e3 ch\u1ee9ng minh vai tr\u00f2 c\u1ee7a con \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u ONOO-\/PARP trong ch\u1ea5n th\u01b0\u01a1ng n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9. C\u00e1c th\u00ed nghi\u1ec7m in vivo cho th\u1ea5y chu\u1ed9t thi\u1ebfu NOS bi\u1ec3u hi\u1ec7n \u00edt k\u00edch ho\u1ea1t PARP h\u01a1n trong m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt b\u1ecb \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9. C\u00e1c th\u00ed nghi\u1ec7m in vitro cho th\u1ea5y c\u00e1c nh\u00e0 t\u00e0i tr\u1ee3 ONOO, ch\u1ee9 kh\u00f4ng ph\u1ea3i c\u00e1c nh\u00e0 t\u00e0i tr\u1ee3 NO, g\u00e2y ra s\u1ef1 k\u00edch ho\u1ea1t \u0111\u00e1ng k\u1ec3 PARP \u1edf C6 nu\u00f4i c\u1ea5y\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c t\u1ebf b\u00e0o u th\u1ea7n kinh \u0111\u1ec7m t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glioma-cell\">t\u1ebf b\u00e0o u th\u1ea7n kinh \u0111\u1ec7m<\/a>.\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 s\u1ef1 gi\u00e1n \u0111o\u1ea1n gen t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/gene-disruption\">S\u1ef1 gi\u00e1n \u0111o\u1ea1n gen<\/a>\u00a0ho\u1eb7c s\u1ef1 im l\u1eb7ng c\u1ee7a PARP l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 k\u00edch th\u01b0\u1edbc nh\u1ed3i m\u00e1u n\u00e3o t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-infarction-size\">k\u00edch th\u01b0\u1edbc nh\u1ed3i m\u00e1u n\u00e3o<\/a>, l\u00e0m gi\u1ea3m b\u1edbt\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 \u0111\u1ed9c t\u00ednh th\u1ea7n kinh t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neurotoxicity\">\u0111\u1ed9c t\u00ednh th\u1ea7n kinh<\/a>, b\u1ea3o v\u1ec7 c\u00e1c \u0111\u01a1n v\u1ecb th\u1ea7n kinh m\u1ea1ch m\u00e1u v\u00e0 c\u1ea3i thi\u1ec7n k\u1ebft qu\u1ea3 th\u1ea7n kinh\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib136\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib136\"><span class=\"anchor-text\">[136]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib137\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib137\"><span class=\"anchor-text\">[137]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib138\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib138\"><span class=\"anchor-text\">[138]<\/span><\/a>. C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng ROS\/RNS c\u00f3 th\u1ec3 l\u00e0 t\u00e1c nh\u00e2n k\u00edch ho\u1ea1t h\u1ed3ng c\u1ea7u trong CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib139\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib139\"><span class=\"anchor-text\">[139]<\/span><\/a>. Inflammasome l\u00e0 m\u1ed9t ph\u1ee9c h\u1ee3p \u0111a protein trong t\u1ebf b\u00e0o ch\u1ea5t c\u1ee7a microglia, trong \u0111\u00f3 th\u1ee5 th\u1ec3 gi\u1ed1ng NOD 3 (NLRP3) l\u00e0 th\u1ee5 th\u1ec3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u r\u1ed9ng r\u00e3i nh\u1ea5t. NLRP3 k\u00edch ho\u1ea1t v\u00e0 k\u00edch ho\u1ea1t caspase-1, k\u00edch ho\u1ea1t IL-1\u03b2 v\u00e0 IL-18 v\u00e0 gi\u1ea3i ph\u00f3ng ch\u00fang v\u00e0o\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 kh\u00f4ng gian ngo\u1ea1i b\u00e0o t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/extracellular-space\">kh\u00f4ng gian ngo\u1ea1i b\u00e0o<\/a>, th\u00fac \u0111\u1ea9y s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a ch\u1ee9ng vi\u00eam\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib140\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib140\"><span class=\"anchor-text\">[140]<\/span><\/a>. C\u00e1c th\u00ed nghi\u1ec7m in vivo cho th\u1ea5y k\u00edch th\u01b0\u1edbc v\u00f9ng nh\u1ed3i m\u00e1u n\u00e3o v\u00e0 t\u1ed5n th\u01b0\u01a1ng BBB \u1edf chu\u1ed9t b\u1ecb lo\u1ea1i NLPR3 th\u1ea5p h\u01a1n so v\u1edbi chu\u1ed9t hoang d\u00e3. C\u00e1c th\u00ed nghi\u1ec7m ti\u1ebfp theo cho th\u1ea5y NLRP3 c\u00f3 th\u1ec3 l\u00e0m trung gian gi\u1ea3i ph\u00f3ng IL-1\u03b2 v\u00e0 t\u0103ng t\u00ednh th\u1ea5m c\u1ee7a t\u1ebf b\u00e0o n\u1ed9i m\u00f4 m\u1ea1ch m\u00e1u n\u00e3o\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib141\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib141\"><span class=\"anchor-text\">[141]<\/span><\/a>. Y\u1ebfu t\u1ed1 h\u1ea1t nh\u00e2n li\u00ean quan \u0111\u1ebfn E2\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 y\u1ebfu t\u1ed1 2 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/prothrombin\">y\u1ebfu t\u1ed1 2<\/a>\u00a0(Nrf2) \u0111i\u1ec1u ch\u1ec9nh c\u00e1c ph\u1ea3n \u1ee9ng ch\u1ed1ng oxy h\u00f3a c\u1ee7a t\u1ebf b\u00e0o v\u00e0 Nrf2 \u1ee9c ch\u1ebf s\u1ea3n xu\u1ea5t NLRP3 qua trung gian ROS trong microglia BV2 trong \u0111i\u1ec1u ki\u1ec7n thi\u1ebfu oxy v\u00e0 glucose\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib142\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib142\"><span class=\"anchor-text\">[142]<\/span><\/a>. Ng\u01b0\u1eddi ta ph\u00e1t hi\u1ec7n ra r\u1eb1ng stress oxy h\u00f3a\/nitrosit g\u00e2y ra s\u1ef1 h\u00ecnh th\u00e0nh peroxynitrite, c\u00f3 th\u1ec3 l\u00e0 t\u00e1c nh\u00e2n ch\u00ednh k\u00edch ho\u1ea1t caspase1\/inflammasome\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib143\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib143\"><span class=\"anchor-text\">[143]<\/span><\/a>. Do \u0111\u00f3, c\u00e1c d\u00f2ng si\u00eau nh\u1ecf qua trung gian ROS\/RNS c\u00f3 th\u1ec3 l\u00e0 m\u1ee5c ti\u00eau \u0111i\u1ec1u tr\u1ecb ti\u1ec1m n\u0103ng cho ch\u1ea5n th\u01b0\u01a1ng n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9.<\/p>\n<p id=\"p0105\">Ngo\u00e0i ra, ROS\/RNS l\u00e0m trung gian cho vi\u1ec7c k\u00edch ho\u1ea1t c\u00e1c th\u1ee5 th\u1ec3 gi\u1ed1ng Toll. C\u00e1c nghi\u00ean c\u1ee9u hi\u1ec7n t\u1ea1i \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng c\u00e1c th\u1ee5 th\u1ec3 gi\u1ed1ng Toll (TLR) \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u r\u1ed9ng r\u00e3i nh\u01b0 m\u1ed9t th\u1ee5 th\u1ec3 b\u1ea9m sinh.\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 th\u1ee5 th\u1ec3 mi\u1ec5n d\u1ecbch t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immune-system-receptors\">th\u1ee5 th\u1ec3 mi\u1ec5n d\u1ecbch<\/a>v\u00e0 TLR4\/2 \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u nhi\u1ec1u h\u01a1n \u1edf n\u00e3o\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 ch\u1ea5n th\u01b0\u01a1ng do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemic-injury\">ch\u1ea5n th\u01b0\u01a1ng do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9<\/a>.\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 TLR4 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/toll-like-receptor-4\">TLR4<\/a>\u00a0c\u00f3 th\u1ec3 l\u00e0m trung gian cho s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a IL-1\u03b2, MMP-9, iNOS v\u00e0 COX-2, \u0111\u1ed3ng th\u1eddi l\u00e0m n\u1eb7ng th\u00eam t\u1ed5n th\u01b0\u01a1ng n\u00e3o do stress oxy h\u00f3a g\u00e2y ra\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib144\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib144\"><span class=\"anchor-text\">[144]<\/span><\/a>. \u1ee8ng d\u1ee5ng c\u1ee7a ch\u1ea5t \u1ee9c ch\u1ebf TLR4\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 E5564 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/eritoran\">E5564<\/a>\u00a0cho th\u1ea5y r\u1eb1ng n\u00f3 c\u00f3 th\u1ec3 ch\u01a1i m\u1ed9t\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 ch\u1ea5t b\u1ea3o v\u1ec7 th\u1ea7n kinh t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroprotective-agent\">b\u1ea3o v\u1ec7 th\u1ea7n kinh<\/a>\u00a0vai tr\u00f2 b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf s\u1ef1 k\u00edch ho\u1ea1t c\u1ee7a microglia v\u00e0 s\u1ea3n xu\u1ea5t ROS\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib145\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib145\"><span class=\"anchor-text\">[145]<\/span><\/a>. Sau IS, k\u00edch th\u01b0\u1edbc v\u00f9ng nh\u1ed3i m\u00e1u c\u1ee7a chu\u1ed9t thi\u1ebfu TLR4 nh\u1ecf h\u01a1n \u0111\u00e1ng k\u1ec3 so v\u1edbi chu\u1ed9t hoang d\u00e3\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib146\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib146\"><span class=\"anchor-text\">[146]<\/span><\/a>. TLR4 c\u0169ng tham gia v\u00e0o giai \u0111o\u1ea1n h\u1eadu IS\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 s\u1ef1 h\u00ecnh th\u00e0nh th\u1ea7n kinh t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neurogenesis\">s\u1ef1 h\u00ecnh th\u00e0nh th\u1ea7n kinh<\/a>.\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 ch\u1ee5p c\u1eaft l\u1edbp ph\u00e1t x\u1ea1 Positron t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/positron-emission-tomography\">Ch\u1ee5p c\u1eaft l\u1edbp ph\u00e1t x\u1ea1 positron<\/a>\u00a0c\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng nh\u1eefng con chu\u1ed9t thi\u1ebfu TLR4 \u0111\u00e3 t\u0103ng c\u01b0\u1eddng s\u1ef1 h\u00ecnh th\u00e0nh th\u1ea7n kinh v\u00e0 \u1ee9c ch\u1ebf c\u00e1c ph\u1ea3n \u1ee9ng vi\u00eam \u1edf IS\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib147\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib147\"><span class=\"anchor-text\">[147]<\/span><\/a>. Ngo\u00e0i ra, c\u00e1c nghi\u00ean c\u1ee9u th\u1ef1c nghi\u1ec7m in vivo \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng vi\u1ec7c \u1ee9c ch\u1ebf \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u TLR2\/4\/NF-\u03baB c\u00f3 t\u00e1c d\u1ee5ng nh\u1ea5t \u0111\u1ecbnh trong vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh stress oxy h\u00f3a, ph\u1ea3n \u1ee9ng vi\u00eam v\u00e0 b\u1ea3o v\u1ec7 m\u00f4 n\u00e3o thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib148\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib148\"><span class=\"anchor-text\">[148]<\/span><\/a>. Do \u0111\u00f3, TLR4\/2 c\u00f3 th\u1ec3 l\u00e0 m\u1ee5c ti\u00eau \u0111i\u1ec1u tr\u1ecb ch\u1ea5n th\u01b0\u01a1ng n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9.<\/p>\n<\/section>\n<\/section>\n<section id=\"sec0065\">\n<h2 id=\"sect0085\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">3. M\u1ed1i li\u00ean h\u1ec7 gi\u1eefa ch\u1ee9ng pyroptosis v\u00e0 IS<\/h2>\n<p id=\"p0110\">C\u01a1 ch\u1ebf b\u1ec7nh l\u00fd c\u1ee7a b\u1ec7nh n\u00e3o\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 b\u1ec7nh thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemia\">thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9<\/a>\u00a0v\u00e0 t\u1ed5n th\u01b0\u01a1ng sau t\u00e1i t\u01b0\u1edbi m\u00e1u sau thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 r\u1ea5t ph\u1ee9c t\u1ea1p. C\u00e1c c\u01a1 ch\u1ebf li\u00ean quan \u0111\u1ebfn qu\u00e1 tr\u00ecnh n\u00e0y bao g\u1ed3m vi\u00eam, stress oxy h\u00f3a, qu\u00e1 tr\u00ecnh t\u1ef1 th\u1ef1c b\u00e0o, r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng ty th\u1ec3, qu\u00e1 t\u1ea3i canxi v\u00e0 ch\u1ebft t\u1ebf b\u00e0o theo ch\u01b0\u01a1ng tr\u00ecnh.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib149\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib149\"><span class=\"anchor-text\">[149]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib150\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib150\"><span class=\"anchor-text\">[150]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib151\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib151\"><span class=\"anchor-text\">[151]<\/span><\/a>. M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng qu\u00e1 tr\u00ecnh ch\u1ebft t\u1ebf b\u00e0o theo ch\u01b0\u01a1ng tr\u00ecnh c\u00f3 vai tr\u00f2 quan tr\u1ecdng trong qu\u00e1 tr\u00ecnh b\u1ec7nh l\u00fd c\u1ee7a thi\u1ebfu m\u00e1u n\u00e3o v\u00e0 t\u1ed5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9, c\u00f3 m\u1ed1i li\u00ean h\u1ec7 m\u1eadt thi\u1ebft v\u1edbi nhau v\u00e0 ch\u1eb7t ch\u1ebd v\u1edbi c\u00e1c c\u01a1 ch\u1ebf tr\u00ean, \u0111\u1eb7c bi\u1ec7t l\u00e0 b\u1ec7nh pyroptosis.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib152\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib152\"><span class=\"anchor-text\">[152]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib153\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib153\"><span class=\"anchor-text\">[153]<\/span><\/a>. S\u1ef1 ch\u1ebft t\u1ebf b\u00e0o theo ch\u01b0\u01a1ng tr\u00ecnh l\u00e0 bi\u1ebfn c\u1ed1 ch\u00ednh c\u1ee7a \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9, li\u00ean quan \u0111\u1ebfn t\u1ebf b\u00e0o th\u1ea7n kinh,\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 microglia t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microglia\">microglia<\/a>, t\u1ebf b\u00e0o h\u00ecnh sao,\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c t\u1ebf b\u00e0o n\u1ed9i m\u00f4 m\u1ea1ch m\u00e1u t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascular-endothelial-cell\">t\u1ebf b\u00e0o n\u1ed9i m\u00f4 m\u1ea1ch m\u00e1u<\/a>, v.v., ch\u1eb3ng h\u1ea1n nh\u01b0 apoptosis\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib154\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib154\"><span class=\"anchor-text\">[154]<\/span><\/a>, t\u1ef1 th\u1ef1c\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib155\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib155\"><span class=\"anchor-text\">[155]<\/span><\/a>, ho\u1ea1i t\u1eed theo ch\u01b0\u01a1ng tr\u00ecnh ho\u1eb7c ho\u1ea1i t\u1eed\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib156\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib156\"><span class=\"anchor-text\">[156]<\/span><\/a>,\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 b\u1ec7nh ferroptosis t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ferroptosis\">b\u1ec7nh s\u1eaft t\u1eeb<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib157\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib157\"><span class=\"anchor-text\">[157]<\/span><\/a>, v\u00e0 b\u1ec7nh pyroptosis\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib158\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib158\"><span class=\"anchor-text\">[158]<\/span><\/a>. \u0110\u1eb7c bi\u1ec7t trong b\u1ec7nh pyroptosis, s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a c\u00e1c protein li\u00ean quan \u0111\u1ebfn pyroptosis nh\u01b0 NLRP1, ASC, Caspase-1 v\u00e0 GSDMD t\u0103ng l\u00ean trong m\u00f4 h\u00ecnh chu\u1ed9t b\u1ecb thi\u1ebfu m\u00e1u n\u00e3o v\u00e0 vi\u1ec7c \u1ee9c ch\u1ebf NLRP1 c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m t\u00ecnh tr\u1ea1ng vi\u00eam v\u00e0 n\u00e3o.\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 ch\u1ea5n th\u01b0\u01a1ng do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemic-injury\">ch\u1ea5n th\u01b0\u01a1ng do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9<\/a>. Ngo\u00e0i ra, trong tr\u01b0\u1eddng h\u1ee3p thi\u1ebfu m\u00e1u n\u00e3o m\u00e3n t\u00ednh, c\u00e1c t\u1ebf b\u00e0o th\u00fac \u0111\u1ea9y ph\u1ea3n \u1ee9ng vi\u00eam b\u1eb1ng c\u00e1ch gi\u1ea3i ph\u00f3ng c\u00e1c t\u00edn hi\u1ec7u nh\u01b0 DAMPs v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 PAMP t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathogen-associated-molecular-pattern\">PAMP<\/a>v\u00e0 k\u00edch ho\u1ea1t m\u1ed9t lo\u1ea1t ph\u1ea3n \u1ee9ng ph\u00e2n t\u1eed ph\u1ee9c t\u1ea1p. T\u1ea1i th\u1eddi \u0111i\u1ec3m n\u00e0y, c\u00e1c t\u1ebf b\u00e0o vi\u00eam th\u1ea7n kinh mi\u1ec5n d\u1ecbch n\u1ed9i s\u1ecd, ch\u1eb3ng h\u1ea1n nh\u01b0 microglia v\u00e0 t\u1ebf b\u00e0o h\u00ecnh sao, d\u01b0\u1eddng nh\u01b0 sinh s\u00f4i n\u1ea3y n\u1edf v\u00e0 k\u00edch ho\u1ea1t, l\u00e0m t\u1ed5n th\u01b0\u01a1ng th\u00eam \u0111\u01a1n v\u1ecb m\u1ea1ch m\u00e1u th\u1ea7n kinh.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib159\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib159\"><span class=\"anchor-text\">[159]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib160\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib160\"><span class=\"anchor-text\">[160]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib161\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib161\"><span class=\"anchor-text\">[161]<\/span><\/a>.<\/p>\n<section id=\"sec0070\">\n<h3 id=\"sect0090\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">3.1. Pyroptosis v\u00e0 t\u1ebf b\u00e0o th\u1ea7n kinh<\/h3>\n<p id=\"p0115\">Sau IS, ho\u1ea1i t\u1eed x\u1ea3y ra \u1edf v\u00f9ng thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 trung t\u00e2m trong th\u1eddi gian ng\u1eafn v\u00e0 t\u1ebf b\u00e0o ch\u1ebft ph\u00e1t ra c\u00e1c t\u00edn hi\u1ec7u nguy hi\u1ec3m nh\u01b0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 protein HMGB1 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/high-mobility-group-b1-protein\">protein HMGB1<\/a>,\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 protein s\u1ed1c nhi\u1ec7t t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/heat-shock-protein\">Protein s\u1ed1c nhi\u1ec7t<\/a>,\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 peroxidase t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/peroxidase\">peroxidaza<\/a>\u00a0protein gia \u0111\u00ecnh, v.v. Nh\u1eefng ph\u00e2n t\u1eed t\u00edn hi\u1ec7u nguy hi\u1ec3m n\u00e0y li\u00ean k\u1ebft v\u1edbi\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u01a1 quan ti\u1ebfp nh\u1eadn nh\u1eadn d\u1ea1ng m\u1eabu t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pattern-recognition-receptor\">th\u1ee5 th\u1ec3 nh\u1eadn d\u1ea1ng m\u1eabu<\/a>, h\u00ecnh th\u1ee9c\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c d\u00f2ng si\u00eau nh\u1ecf t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammasome\">h\u1ed3ng c\u1ea7u<\/a>, k\u00edch ho\u1ea1t c\u00e1c ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch b\u1ea9m sinh v\u00e0 g\u00e2y ch\u1ebft t\u1ebf b\u00e0o th\u1ea7n kinh\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib162\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib162\"><span class=\"anchor-text\">[162]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib163\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib163\"><span class=\"anchor-text\">[163]<\/span><\/a>. C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 x\u00e1c nh\u1eadn r\u1eb1ng thi\u1ebfu m\u00e1u n\u00e3o c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn bi\u1ec3u hi\u1ec7n cao c\u1ee7a NLRP1 v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 NLRP3 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nucleotide-binding-oligomerization-domain-like-receptor\">NLRP3<\/a>\u00a0trong m\u00f4 n\u00e3o v\u00e0 t\u1ebf b\u00e0o th\u1ea7n kinh thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9, v\u00e0 vi\u1ec7c k\u00edch ho\u1ea1t NLRP1 ch\u1ee7 y\u1ebfu t\u1ed3n t\u1ea1i trong t\u1ebf b\u00e0o th\u1ea7n kinh\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib164\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib164\"><span class=\"anchor-text\">[164]<\/span><\/a>. Vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf Caspase-1 ho\u1eb7c c\u00e1c ch\u1ebf ph\u1ea9m globulin mi\u1ec5n d\u1ecbch c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a NLRP1 v\u00e0 NLRP3 trong c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh v\u1ecf n\u00e3o nguy\u00ean ph\u00e1t v\u00e0 l\u00e0m gi\u1ea3m k\u00edch th\u01b0\u1edbc c\u1ee7a\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 nh\u1ed3i m\u00e1u n\u00e3o t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-infarction\">nh\u1ed3i m\u00e1u n\u00e3o<\/a>v\u00e0 c\u01a1 ch\u1ebf n\u00e0y c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn s\u1ef1 \u1ee9c ch\u1ebf k\u00edch ho\u1ea1t \u0111\u01b0\u1eddng d\u1eabn NF-\u03baB v\u00e0 MAPK\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib164\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib164\"><span class=\"anchor-text\">[164]<\/span><\/a>. \u1ede chu\u1ed9t IS Li et al.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib165\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib165\"><span class=\"anchor-text\">[165]<\/span><\/a>\u00a0ph\u00e1t hi\u1ec7n ra r\u1eb1ng v\u00e0o ng\u00e0y th\u1ee9 3 sau khi thi\u1ebfu m\u00e1u n\u00e3o, t\u1ed5n th\u01b0\u01a1ng si\u00eau c\u1ea5u tr\u00fac c\u1ee7a huy\u1ebft t\u01b0\u01a1ng th\u1ea7n kinh, h\u1ea1t nh\u00e2n v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 m\u00e0ng ty th\u1ec3 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitochondrial-membrane\">m\u00e0ng ty th\u1ec3<\/a>\u00a0\u0111\u00e3 x\u1ea3y ra v\u00e0 c\u00e1c bi\u1ec3u hi\u1ec7n c\u1ee7a Caspase-1, GSDMD v\u00e0 IL-1\u03b2 \u0111\u00e3 t\u0103ng l\u00ean \u0111\u00e1ng k\u1ec3. Ch\u1ea5t \u1ee9c ch\u1ebf Caspase-1\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Vx765 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/belnacasan\">Vx765<\/a>\u00a0c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf ch\u1ee9ng pyroptosis, th\u00fac \u0111\u1ea9y s\u1ef1 s\u1ed1ng s\u00f3t c\u1ee7a t\u1ebf b\u00e0o th\u1ea7n kinh \u1edf nh\u1eefng v\u00f9ng thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 v\u00e0 c\u1ea3i thi\u1ec7n\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng n\u00e3o t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-dysfunction\">r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng n\u00e3o<\/a>\u00a0\u1edf chu\u1ed9t. Liang v\u00e0 c\u1ed9ng s\u1ef1.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib166\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib166\"><span class=\"anchor-text\">[166]<\/span><\/a>\u00a0ph\u00e1t hi\u1ec7n ra r\u1eb1ng gen 3 (MEG3) bi\u1ec3u hi\u1ec7n RNA kh\u00f4ng m\u00e3 h\u00f3a d\u00e0i t\u1eeb m\u1eb9 th\u00fac \u0111\u1ea9y ch\u1ee9ng pyroptosis v\u00e0 ph\u1ea3n \u1ee9ng vi\u00eam b\u1eb1ng c\u00e1ch k\u00edch ho\u1ea1t con \u0111\u01b0\u1eddng AIM2\/Caspase-1, d\u1eabn \u0111\u1ebfn t\u1ed5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 n\u00e3o. Vi\u1ec7c lo\u1ea1i b\u1ecf gen MEG3 c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 AIM2 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nodular-melanoma\">AIM2<\/a>, Caspase-1, GSDMD v\u00e0 c\u00e1c protein kh\u00e1c, \u0111\u1ed3ng th\u1eddi l\u00e0m gi\u1ea3m ch\u1ea5n th\u01b0\u01a1ng n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y MEG3 c\u00f3 th\u1ec3 l\u00e0 m\u1ee5c ti\u00eau \u0111i\u1ec1u tr\u1ecb hi\u1ec7u qu\u1ea3 cho b\u1ec7nh \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9.<\/p>\n<\/section>\n<section id=\"sec0075\">\n<h3 id=\"sect0095\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">3.2. Pyroptosis v\u00e0 t\u1ebf b\u00e0o h\u00ecnh sao<\/h3>\n<p id=\"p0120\">T\u1ebf b\u00e0o h\u00ecnh sao c\u00f3 nhi\u1ec1u nh\u1ea5t\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 t\u1ebf b\u00e0o th\u1ea7n kinh \u0111\u1ec7m t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glial-cells\">t\u1ebf b\u00e0o th\u1ea7n kinh \u0111\u1ec7m<\/a>\u00a0b\u00ean trong\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/central-nervous-system\">h\u1ec7 th\u1ed1ng th\u1ea7n kinh trung \u01b0\u01a1ng<\/a>\u00a0v\u00e0 tham gia v\u00e0o vi\u1ec7c h\u00ecnh th\u00e0nh h\u00e0ng r\u00e0o m\u00e1u n\u00e3o, \u0111i\u1ec1u h\u00f2a chuy\u1ec3n h\u00f3a t\u1ebf b\u00e0o th\u1ea7n kinh v\u00e0 \u1ed5n \u0111\u1ecbnh giao ti\u1ebfp gi\u1eefa c\u00e1c t\u1ebf b\u00e0o\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib167\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib167\"><span class=\"anchor-text\">[167]<\/span><\/a>. Sau IS, m\u1ed9t s\u1ef1 thay \u0111\u1ed5i b\u1ec7nh l\u00fd n\u1ed5i b\u1eadt c\u00f3 t\u00ednh ph\u1ea3n \u1ee9ng\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 b\u1ec7nh astrogliosis t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/astrocytosis\">b\u1ec7nh astrogliosis<\/a>\u00a0v\u00e0 s\u1eb9o th\u1ea7n kinh \u0111\u1ec7m, gi\u00fap th\u00fac \u0111\u1ea9y t\u00ednh linh ho\u1ea1t c\u1ee7a t\u1ebf b\u00e0o th\u1ea7n kinh s\u1edbm sau ch\u1ea5n th\u01b0\u01a1ng do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib168\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib168\"><span class=\"anchor-text\">[168]<\/span><\/a>. Ng\u01b0\u1eddi ta th\u01b0\u1eddng tin r\u1eb1ng khi\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 h\u1ea3i m\u00e3 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hippocampus\">h\u1ed3i h\u1ea3i m\u00e3<\/a>\u00a0l\u00e0 thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 t\u00ecnh tr\u1ea1ng thi\u1ebfu oxy t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hypoxia\">t\u00ecnh tr\u1ea1ng thi\u1ebfu oxy<\/a>, c\u00e1c\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 kh\u1ea3 n\u0103ng ch\u1ed1ng oxy h\u00f3a t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antioxidant-capacity\">kh\u1ea3 n\u0103ng ch\u1ed1ng oxy h\u00f3a<\/a>\u00a0c\u1ee7a v\u00f9ng h\u1ea3i m\u00e3 s\u1ebd b\u1ecb suy y\u1ebfu v\u00e0 m\u1ed9t s\u1ed1 l\u01b0\u1ee3ng l\u1edbn c\u00e1c y\u1ebfu t\u1ed1 g\u00e2y vi\u00eam c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c gi\u1ea3i ph\u00f3ng, t\u1eeb \u0111\u00f3 l\u00e0m t\u1ed5n th\u01b0\u01a1ng v\u00f9ng h\u1ea3i m\u00e3 tr\u1edf n\u00ean tr\u1ea7m tr\u1ecdng h\u01a1n.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib169\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib169\"><span class=\"anchor-text\">[169]<\/span><\/a>. Ba (3) gi\u1edd sau khi b\u1ecb thi\u1ebfu m\u00e1u n\u00e3o c\u1ee5c b\u1ed9 \u1edf\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 chu\u1ed9t SD t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/sprague-dawley-rat\">chu\u1ed9t SD<\/a>, c\u00e1c t\u1ebf b\u00e0o d\u01b0\u01a1ng t\u00ednh ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch gi\u1ed1ng IL-1\u03b2 xu\u1ea5t hi\u1ec7n \u1edf v\u00f9ng thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9, ch\u1ee7 y\u1ebfu l\u00e0 t\u1ebf b\u00e0o h\u00ecnh sao b\u1ea5t ho\u1ea1t. Cho \u0111\u1ebfn 2 th\u00e1ng sau khi thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9, c\u00e1c t\u1ebf b\u00e0o d\u01b0\u01a1ng t\u00ednh v\u1eabn c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n \u1edf b\u00e1n c\u1ea7u thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9, \u0111\u1eb7c bi\u1ec7t l\u00e0 xung quanh c\u00e1c \u1ed5 ho\u1ea1i t\u1eed v\u00e0 m\u1ee9c \u0111\u1ed9 k\u00edch ho\u1ea1t c\u00e0ng cao.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib170\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib170\"><span class=\"anchor-text\">[170]<\/span><\/a>. T\u1ebf b\u00e0o h\u00ecnh sao \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t c\u00f3 th\u1ec3 t\u1ea1o ra s\u1ef1 gi\u1ea3i ph\u00f3ng\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 y\u1ebfu t\u1ed1 ho\u1ea1i t\u1eed kh\u1ed1i u t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tumor-necrosis-factor\">y\u1ebfu t\u1ed1 ho\u1ea1i t\u1eed kh\u1ed1i u<\/a>, interleukin, y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng v\u00e0 c\u00e1c y\u1ebfu t\u1ed1 g\u00e2y vi\u00eam kh\u00e1c ho\u1eb7c c\u00e1c ch\u1ea5t trung gian g\u00e2y \u0111\u1ed9c cho t\u1ebf b\u00e0o th\u1ea7n kinh, d\u1eabn \u0111\u1ebfn t\u1ed5n th\u01b0\u01a1ng t\u1ebf b\u00e0o th\u1ea7n kinh\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib171\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib171\"><span class=\"anchor-text\">[171]<\/span><\/a>. NLRP2 ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c bi\u1ec3u hi\u1ec7n \u1edf t\u1ebf b\u00e0o h\u00ecnh sao, nh\u01b0ng h\u1ea7u nh\u01b0 kh\u00f4ng bi\u1ec3u hi\u1ec7n \u1edf t\u1ebf b\u00e0o th\u1ea7n kinh v\u00e0 microglia. H\u01a1n n\u1eefa, s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a NLRP2 \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh t\u0103ng \u0111\u00e1ng k\u1ec3 trong m\u00f4 h\u00ecnh thi\u1ebfu m\u00e1u n\u00e3o \u1edf chu\u1ed9t v\u00e0 sau khi thi\u1ebfu oxy v\u00e0 glucose trong t\u1ebf b\u00e0o h\u00ecnh sao, v\u00e0 vi\u1ec7c l\u00e0m im l\u1eb7ng NLRP2 c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m ch\u1ee9ng pyroptosis g\u00e2y ra do thi\u1ebfu oxy v\u00e0 glucose\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib172\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib172\"><span class=\"anchor-text\">[172]<\/span><\/a>. M\u1ed9t nghi\u00ean c\u1ee9u kh\u00e1c cho th\u1ea5y trong m\u00f4 h\u00ecnh in vitro c\u1ee7a thi\u1ebfu m\u00e1u n\u00e3o, s\u1ef1 thi\u1ebfu h\u1ee5t oxy-glucose d\u1eabn \u0111\u1ebfn s\u1ef1 gia t\u0103ng NLRP3, ASC, Caspase-1, IL-1\u03b2 v\u00e0 IL-18, \u0111\u1ed3ng th\u1eddi gi\u1ea3m kh\u1ea3 n\u0103ng s\u1ed1ng s\u00f3t c\u1ee7a t\u1ebf b\u00e0o h\u00ecnh sao.\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Hispidulin t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hispidulin\">Hispidulin<\/a>\u00a0l\u00e0 m\u1ed9t h\u1ee3p ch\u1ea5t xeton \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp t\u1eeb\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 thu\u1ed1c th\u1ea3o d\u01b0\u1ee3c Trung Qu\u1ed1c t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chinese-herbal-medicine\">Thu\u1ed1c th\u1ea3o d\u01b0\u1ee3c Trung Qu\u1ed1c<\/a>. C\u00e1c th\u00ed nghi\u1ec7m in vitro v\u00e0 in vivo \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng Hispidulin c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf b\u1ec7nh pyroptosis qua trung gian NLRP3 v\u00e0 c\u00f3 t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 n\u00e3o, v\u00e0 c\u01a1 ch\u1ebf c\u1ee7a n\u00f3 c\u00f3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c k\u00edch ho\u1ea1t AMPK\/GSK-3\u03b2\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 l\u1ed9 tr\u00ecnh truy\u1ec1n t\u00edn hi\u1ec7u t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/signal-transduction\">\u0111\u01b0\u1eddng t\u00edn hi\u1ec7u<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib173\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib173\"><span class=\"anchor-text\">[173]<\/span><\/a>. M\u1ea1nh v\u00e0 c\u1ed9ng s\u1ef1.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib174\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib174\"><span class=\"anchor-text\">[174]<\/span><\/a>\u00a0nh\u1eadn th\u1ea5y r\u1eb1ng bi\u1ec3u hi\u1ec7n c\u1ee7a NLRP6 \u0111\u1ea1t \u0111\u1ebfn \u0111\u1ec9nh \u0111i\u1ec3m sau 48 gi\u1edd sau khi t\u00e1i t\u01b0\u1edbi m\u00e1u n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 \u1edf chu\u1ed9t. Sau khi thi\u1ebfu oxy v\u00e0 glucose trong t\u1ebf b\u00e0o h\u00ecnh sao, vi\u1ec7c s\u1ea3n xu\u1ea5t NLRP6 v\u00e0 c\u00e1c s\u1ea3n ph\u1ea9m k\u00edch ho\u1ea1t c\u1ee7a n\u00f3 t\u0103ng l\u00ean, \u0111\u1ed3ng th\u1eddi vi\u1ec7c l\u00e0m im l\u1eb7ng NLRP6 c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m ASC v\u00e0 Caspase-1, gi\u1ea3m s\u1ef1 gi\u1ea3i ph\u00f3ng c\u00e1c y\u1ebfu t\u1ed1 g\u00e2y vi\u00eam v\u00e0 t\u0103ng ho\u1ea1t \u0111\u1ed9ng c\u1ee7a t\u1ebf b\u00e0o th\u1ea7n kinh\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib175\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib175\"><span class=\"anchor-text\">[175]<\/span><\/a>. Do \u0111\u00f3, c\u00e1c bi\u1ec7n ph\u00e1p can thi\u1ec7p nh\u1eafm m\u1ee5c ti\u00eau k\u00edch ho\u1ea1t h\u1ed3ng c\u1ea7u trong t\u1ebf b\u00e0o h\u00ecnh sao c\u00f3 th\u1ec3 mang l\u1ea1i nh\u1eefng \u00fd t\u01b0\u1edfng m\u1edbi cho vi\u1ec7c \u0111i\u1ec1u tr\u1ecb IS.<\/p>\n<\/section>\n<section id=\"sec0080\">\n<h3 id=\"sect0100\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">3.3. B\u1ec7nh pyroptosis v\u00e0 microglia<\/h3>\n<p id=\"p0125\">Microglia l\u00e0 b\u1ea9m sinh\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunocompetent-cell\">t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch<\/a>\u00a0c\u1ee7a h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng v\u00e0 c\u00e1c t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t s\u1edbm nh\u1ea5t sau \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib176\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib176\"><span class=\"anchor-text\">[176]<\/span><\/a>. Trong giai \u0111o\u1ea1n c\u1ea5p t\u00ednh c\u1ee7a t\u1ed5n th\u01b0\u01a1ng thi\u1ebfu m\u00e1u n\u00e3o, microglia nhanh ch\u00f3ng di chuy\u1ec3n \u0111\u1ebfn v\u1ecb tr\u00ed t\u1ed5n th\u01b0\u01a1ng v\u00e0 ti\u1ebft ra c\u00e1c y\u1ebfu t\u1ed1 g\u00e2y vi\u00eam v\u00e0 ch\u1ea5t g\u00e2y \u0111\u1ed9c t\u1ebf b\u00e0o, l\u00e0m n\u1eb7ng th\u00eam t\u1ed5n th\u01b0\u01a1ng m\u00f4.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib177\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib177\"><span class=\"anchor-text\">[177]<\/span><\/a>. \u1ede giai \u0111o\u1ea1n m\u00e3n t\u00ednh, microglia c\u00f3 th\u1ec3 s\u1ea3n xu\u1ea5t ra c\u00e1c cytokine ch\u1ed1ng vi\u00eam v\u00e0 c\u00e1c y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng \u0111\u1ec3 th\u00fac \u0111\u1ea9y\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 s\u1eeda ch\u1eefa m\u00f4 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tissue-repair\">s\u1eeda ch\u1eefa m\u00f4<\/a>\u00a0v\u00e0 tu s\u1eeda\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib178\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib178\"><span class=\"anchor-text\">[178]<\/span><\/a>. C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng b\u1ec7nh pyroptosis vi m\u00f4 \u0111\u00f3ng m\u1ed9t vai tr\u00f2 quan tr\u1ecdng trong ch\u1ea5n th\u01b0\u01a1ng n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9. NLRC4 l\u00e0 d\u00f2ng h\u1ed3ng c\u1ea7u \u0111\u1ea7u ti\u00ean t\u0103ng \u0111\u00e1ng k\u1ec3 khi microglia b\u1ecb thi\u1ebfu oxy v\u00e0 glucose trong 3 gi\u1edd, trong khi NLRP1, NLRP3 v\u00e0 AIM2 kh\u00f4ng t\u0103ng \u0111\u00e1ng k\u1ec3 cho \u0111\u1ebfn sau 6 gi\u1edd thi\u1ebfu glucose oxy. Vi\u1ec7c l\u00e0m im l\u1eb7ng NLRC4 c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m vi\u1ec7c s\u1ea3n xu\u1ea5t GSDMD, IL-1\u03b2 v\u00e0 IL-18, \u0111\u1ed3ng th\u1eddi \u1ee9c ch\u1ebf b\u1ec7nh pyroptosis vi m\u00f4\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib179\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib179\"><span class=\"anchor-text\">[179]<\/span><\/a>. Xu v\u00e0 c\u1ed9ng s\u1ef1.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib180\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib180\"><span class=\"anchor-text\">[180]<\/span><\/a>\u00a0b\u00e1o c\u00e1o r\u1eb1ng th\u1ee5 th\u1ec3 tr\u00ecnh \u0111i\u1ec1u khi\u1ec3n 1 (TREM-1) \u0111\u01b0\u1ee3c bi\u1ec3u th\u1ecb b\u1eb1ng\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c t\u1ebf b\u00e0o t\u1ee7y t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/myeloid-cell\">t\u1ebf b\u00e0o t\u1ee7y<\/a>\u00a0trong microglia sau khi t\u00e1i t\u01b0\u1edbi m\u00e1u n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 c\u00f3 th\u1ec3 k\u00edch ho\u1ea1t con \u0111\u01b0\u1eddng pyroptosis qua trung gian NLRP3\/Caspase-1 v\u00e0 g\u00e2y ra ph\u1ea3n \u1ee9ng vi\u00eam th\u1ea7n kinh. S\u1ef1 \u1ee9c ch\u1ebf TREM-1 l\u00e0m gi\u1ea3m ch\u1ee9ng pyroptosis vi m\u00f4 v\u00e0 t\u1ed5n th\u01b0\u01a1ng th\u1ea7n kinh. Li v\u00e0 c\u1ed9ng s\u1ef1.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib181\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib181\"><span class=\"anchor-text\">[181]<\/span><\/a>\u00a0x\u00e1c nh\u1eadn r\u1eb1ng s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a guanosine monophosphate-adenosine synthase (cGAS) theo chu k\u1ef3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh t\u0103ng sau khi thi\u1ebfu m\u00e1u n\u00e3o c\u1ee5c b\u1ed9 v\u00e0 k\u00edch ho\u1ea1t d\u00f2ng h\u1ed3ng c\u1ea7u AIM2 \u0111\u1ec3 g\u00e2y ra b\u1ec7nh pyroptosis vi m\u00f4. Ch\u1ea5t \u0111\u1ed1i kh\u00e1ng cGAS A151 c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf ho\u1ea1t h\u00f3a AIM2 v\u00e0 ch\u1ee9ng pyroptosis vi m\u00f4, l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 th\u1ec3 t\u00edch nh\u1ed3i m\u00e1u n\u00e3o v\u00e0 gi\u1ea3m b\u1edbt t\u1ed5n th\u01b0\u01a1ng th\u1ea7n kinh. C\u00e1c nghi\u00ean c\u1ee9u tr\u00ean ch\u1ec9 ra r\u1eb1ng ch\u1ee9ng pyroptosis microglia v\u00e0 ph\u1ea3n \u1ee9ng vi\u00eam th\u1ea7n kinh qua trung gian c\u1ee7a n\u00f3 c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t c\u01a1 ch\u1ebf quan tr\u1ecdng d\u1eabn \u0111\u1ebfn ch\u1ea5n th\u01b0\u01a1ng n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9. \u1ee8c ch\u1ebf t\u00e1c d\u1ee5ng g\u00e2y \u0111\u1ed9c th\u1ea7n kinh c\u1ee7a microglia c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t chi\u1ebfn l\u01b0\u1ee3c m\u1edbi trong \u0111i\u1ec1u tr\u1ecb \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9.<\/p>\n<\/section>\n<section id=\"sec0085\">\n<h3 id=\"sect0105\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">3.4. Pyroptosis v\u00e0 t\u1ebf b\u00e0o n\u1ed9i m\u00f4<\/h3>\n<p id=\"p0130\">C\u00e1c t\u1ebf b\u00e0o n\u1ed9i m\u00f4 t\u1ea1o th\u00e0nh h\u00e0ng r\u00e0o \u0111\u1ea7u ti\u00ean c\u1ee7a h\u00e0ng r\u00e0o m\u00e1u n\u00e3o, cung c\u1ea5p gi\u00e0n gi\u00e1o cho\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 claudin t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/claudin\">claudin<\/a>,\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c ph\u00e2n t\u1eed b\u00e1m d\u00ednh t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-adhesion-molecule\">ph\u00e2n t\u1eed b\u00e1m d\u00ednh<\/a>\u00a0V\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 ma tr\u1eadn ngo\u1ea1i b\u00e0o t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/extracellular-matrix\">ma tr\u1eadn ngo\u1ea1i b\u00e0o<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib182\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib182\"><span class=\"anchor-text\">[182]<\/span><\/a>. Trong qu\u00e1 tr\u00ecnh thi\u1ebfu m\u00e1u n\u00e3o, ph\u1ea3n \u1ee9ng vi\u00eam mi\u1ec5n d\u1ecbch v\u00e0 stress oxy h\u00f3a c\u00f3 th\u1ec3 g\u00e2y t\u1ed5n th\u01b0\u01a1ng\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c t\u1ebf b\u00e0o n\u1ed9i m\u00f4 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/endothelial-cell\">t\u1ebf b\u00e0o n\u1ed9i m\u00f4<\/a>\u00a0v\u00e0 ph\u00e1 v\u1ee1 t\u00ednh to\u00e0n v\u1eb9n c\u1ee7a h\u00e0ng r\u00e0o m\u00e1u n\u00e3o, d\u1eabn \u0111\u1ebfn ph\u00f9 m\u1ea1ch, chuy\u1ec3n d\u1ea1ng xu\u1ea5t huy\u1ebft v\u00e0 t\u0103ng t\u1ef7 l\u1ec7 t\u1eed vong.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib183\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib183\"><span class=\"anchor-text\">[183]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib184\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib184\"><span class=\"anchor-text\">[184]<\/span><\/a>. Sau khi b\u1ecb thi\u1ebfu m\u00e1u n\u00e3o, NLRP3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh t\u0103ng trong t\u1ebf b\u00e0o th\u1ea7n kinh, microglia v\u00e0 t\u1ebf b\u00e0o n\u1ed9i m\u00f4 m\u1ea1ch m\u00e1u, v\u00e0 vi\u1ec7c l\u00e0m im l\u1eb7ng gen NLRP3 c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m th\u1ec3 t\u00edch nh\u1ed3i m\u00e1u n\u00e3o \u1edf chu\u1ed9t m\u1eafc b\u1ec7nh\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 \u0111\u1ed9ng m\u1ea1ch n\u00e3o gi\u1eefa t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/middle-cerebral-artery\">\u0110\u1ed9ng m\u1ea1ch n\u00e3o gi\u1eefa<\/a>\u00a0thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 v\u00e0 l\u00e0m gi\u1ea3m t\u00ednh th\u1ea5m c\u1ee7a h\u00e0ng r\u00e0o m\u00e1u n\u00e3o\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib185\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib185\"><span class=\"anchor-text\">[185]<\/span><\/a>. V\u01b0\u01a1ng v\u00e0 c\u1ed9ng s\u1ef1.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib186\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib186\"><span class=\"anchor-text\">[186]<\/span><\/a>\u00a0x\u00e1c nh\u1eadn r\u1eb1ng thi\u1ebfu m\u00e1u n\u00e3o c\u00f3 th\u1ec3 g\u00e2y ra b\u1ec7nh pyroptosis c\u1ee7a c\u00e1c t\u1ebf b\u00e0o n\u1ed9i m\u00f4 vi m\u1ea1ch v\u00e0 l\u00e0m n\u1eb7ng th\u00eam t\u1ed5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9. H\u1ecd c\u0169ng ph\u00e1t hi\u1ec7n ra r\u1eb1ng vi\u1ec7c k\u00edch ho\u1ea1t h\u1ec7 s\u1ed1 gamma th\u1ee5 th\u1ec3 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t b\u1eb1ng ch\u1ea5t t\u0103ng sinh peroxisome 1\u03b1 (PGC-1\u03b1) l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a c\u00e1c protein li\u00ean quan \u0111\u1ebfn ch\u1ee9ng pyroptosis v\u00e0 t\u0103ng bi\u1ec3u hi\u1ec7n c\u1ee7a ZO-1 v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Occludin t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/occludin\">b\u1ecbt k\u00edn<\/a>\u00a0protein trong c\u00e1c t\u1ebf b\u00e0o n\u1ed9i m\u00f4 vi m\u1ea1ch n\u00e3o, \u0111\u1ec3 b\u1ea3o v\u1ec7 t\u00ednh to\u00e0n v\u1eb9n c\u1ee7a h\u00e0ng r\u00e0o m\u00e1u n\u00e3o. Ngo\u00e0i ra, c\u00e1c nghi\u00ean c\u1ee9u c\u00f2n ph\u00e1t hi\u1ec7n hi\u1ec7n t\u01b0\u1ee3ng pyroptosis c\u1ee7a t\u1ebf b\u00e0o n\u1ed9i m\u00f4 m\u1ea1ch m\u00e1u n\u00e3o c\u00f3 th\u1ec3 l\u00e0m t\u0103ng kh\u1ea3 n\u0103ng xu\u1ea5t huy\u1ebft sau IS, d\u1eabn \u0111\u1ebfn c\u00e1c bi\u1ebfn ch\u1ee9ng nghi\u00eam tr\u1ecdng nh\u01b0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 xu\u1ea5t huy\u1ebft n\u00e3o t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebral-hemorrhage\">xu\u1ea5t huy\u1ebft n\u00e3o<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib187\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib187\"><span class=\"anchor-text\">[187]<\/span><\/a>.<\/p>\n<div>\n<p id=\"p0135\">M\u1ed1i li\u00ean quan gi\u1eefa thi\u1ebfu m\u00e1u n\u00e3o c\u1ee5c b\u1ed9 v\u00e0 ch\u1ee9ng pyroptosis \u0111\u01b0\u1ee3c t\u00f3m t\u1eaft trong\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#fig0010\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"fig0010\"><span class=\"anchor-text\">H\u00ecnh 2<\/span><\/a>.<\/p>\n<figure id=\"fig0010\" class=\"figure text-xs\"><img decoding=\"async\" src=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr2.jpg\" alt=\"Fig. 2\" height=\"362\" aria-describedby=\"cap0010\" \/><\/p>\n<ol class=\"u-margin-s-bottom\">\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"T\u1ea3i xu\u1ed1ng h\u00ecnh \u1ea3nh c\u00f3 \u0111\u1ed9 ph\u00e2n gi\u1ea3i cao (274KB)\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr2_lrg.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">T\u1ea3i xu\u1ed1ng :\u00a0<span class=\"download-link-title\">T\u1ea3i xu\u1ed1ng h\u00ecnh \u1ea3nh c\u00f3 \u0111\u1ed9 ph\u00e2n gi\u1ea3i cao (274KB)<\/span><\/span><\/a><\/li>\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"T\u1ea3i xu\u1ed1ng h\u00ecnh \u1ea3nh k\u00edch th\u01b0\u1edbc \u0111\u1ea7y \u0111\u1ee7\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr2.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">T\u1ea3i xu\u1ed1ng :\u00a0<span class=\"download-link-title\">T\u1ea3i xu\u1ed1ng h\u00ecnh \u1ea3nh k\u00edch th\u01b0\u1edbc \u0111\u1ea7y \u0111\u1ee7<\/span><\/span><\/a><\/li>\n<\/ol>\n<p id=\"sp0010\"><span class=\"label\">H\u00ecnh 2<\/span>. T\u00f3m t\u1eaft c\u01a1 ch\u1ebf c\u1ee7a b\u1ec7nh pyroptosis \u1edf c\u00e1c \u0111\u01a1n v\u1ecb t\u1ebf b\u00e0o th\u1ea7n kinh m\u1ea1ch m\u00e1u sau IS [C\u01a1 ch\u1ebf ph\u00e2n t\u1eed c\u1ee7a b\u1ec7nh pyroptosis tr\u00ean c\u00e1c \u0111\u01a1n v\u1ecb t\u1ebf b\u00e0o th\u1ea7n kinh m\u1ea1ch m\u00e1u (bao g\u1ed3m microglia, t\u1ebf b\u00e0o h\u00ecnh sao, t\u1ebf b\u00e0o th\u1ea7n kinh,\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c t\u1ebf b\u00e0o n\u1ed9i m\u00f4 m\u1ea1ch m\u00e1u t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascular-endothelial-cell\">t\u1ebf b\u00e0o n\u1ed9i m\u00f4 m\u1ea1ch m\u00e1u<\/a>, Pericyte) sau IS. IRF:\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 y\u1ebfu t\u1ed1 \u0111i\u1ec1u h\u00f2a interferon t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/interferon-regulatory-factor\">y\u1ebfu t\u1ed1 \u0111i\u1ec1u h\u00f2a interferon<\/a>; N\u1ebeU:\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Interferon t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/interferon\">Interferon<\/a>; CASP: Caspase; GPX4: Glutathione peroxidase 4].<\/p>\n<\/figure>\n<\/div>\n<\/section>\n<\/section>\n<section id=\"sec0090\">\n<h2 id=\"sect0110\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">4. Ti\u1ec1m n\u0103ng \u0111i\u1ec1u tr\u1ecb IS c\u1ee7a thu\u1ed1c \u1ee9c ch\u1ebf pyroptosis<\/h2>\n<p id=\"p0140\">Trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, nghi\u00ean c\u1ee9u v\u1ec1 ch\u1ea5t \u1ee9c ch\u1ebf pyroptosis \u1edf IS nh\u1eadn \u0111\u01b0\u1ee3c nhi\u1ec1u s\u1ef1 quan t\u00e2m. Liang v\u00e0 c\u1ed9ng s\u1ef1.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib188\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib188\"><span class=\"anchor-text\">[188]<\/span><\/a>\u00a0ph\u00e1t hi\u1ec7n ra r\u1eb1ng ch\u1ea5t \u1ee9c ch\u1ebf Caspase-1 VX-765 c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m Caspase-1, ASC, GSDMD v\u00e0 IL-1\u03b2, \u0111\u1ed3ng th\u1eddi \u0111i\u1ec1u ch\u1ec9nh t\u0103ng m\u1ee9c \u0111\u1ed9\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c protein li\u00ean k\u1ebft ch\u1eb7t ch\u1ebd t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tight-junction-protein\">protein li\u00ean k\u1ebft ch\u1eb7t ch\u1ebd<\/a>\u00a0V\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf m\u00f4 c\u1ee7a metallicoproteinase t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/metalloprotease-inhibitor\">ch\u1ea5t \u1ee9c ch\u1ebf m\u00f4 c\u1ee7a metallicoproteinase<\/a>, b\u1ea3o v\u1ec7 s\u1ef1 to\u00e0n v\u1eb9n c\u1ee7a h\u00e0ng r\u00e0o m\u00e1u n\u00e3o. Ngo\u00e0i ra, VX-765 c\u00f2n th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh chuy\u1ec3n \u0111\u1ed5i microglia t\u1eeb lo\u1ea1i M1 sang lo\u1ea1i M2, l\u00e0m gi\u1ea3m ph\u1ea3n \u1ee9ng vi\u00eam qua trung gian microglia v\u00e0 ph\u00e1t huy t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 th\u1ea7n kinh.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib189\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib189\"><span class=\"anchor-text\">[189]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib190\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib190\"><span class=\"anchor-text\">[190]<\/span><\/a>. MCC950 l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf NLRP3 ch\u1ecdn l\u1ecdc. C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng MCC950 c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a NLRP3, Caspase-1 v\u00e0 IL-1\u03b2 \u1edf v\u00f9ng tranh ch\u1ea5p thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 v\u00e0 c\u00f3 t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 \u0111\u1ed1i v\u1edbi t\u00ecnh tr\u1ea1ng thi\u1ebfu m\u00e1u n\u00e3o c\u1ee5c b\u1ed9 \u1edf chu\u1ed9t\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib191\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib191\"><span class=\"anchor-text\">[191]<\/span><\/a>. C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng m\u1ed9t s\u1ed1\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 microRNA t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microrna\">microRNA<\/a>\u00a0c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf hi\u1ec7n t\u01b0\u1ee3ng pyroptosis trong m\u00f4 h\u00ecnh thi\u1ebfu m\u00e1u n\u00e3o v\u00e0 \u0111\u00f3ng vai tr\u00f2 b\u1ea3o v\u1ec7 th\u1ea7n kinh\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib192\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib192\"><span class=\"anchor-text\">[192]<\/span><\/a>. LP17 c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 t\u1ebf b\u00e0o myeloid t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/myeloid-cell\">t\u1ebf b\u00e0o t\u1ee7y<\/a>\u00a0k\u00edch ho\u1ea1t th\u1ee5 th\u1ec3-1, do \u0111\u00f3 \u1ee9c ch\u1ebf stress oxy h\u00f3a v\u00e0 ch\u1ee9ng pyroptosis, \u0111\u1ed3ng th\u1eddi gi\u1ea3m t\u1ed5n th\u01b0\u01a1ng t\u1ebf b\u00e0o th\u1ea7n kinh do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 n\u00e3o g\u00e2y ra\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib192\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib192\"><span class=\"anchor-text\">[192]<\/span><\/a>.\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Histidine t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/histidine\">Histidin<\/a>\u00a0c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf ch\u1ee9ng pyroptosis qua trung gian NLRP3 b\u1eb1ng c\u00e1ch \u0111i\u1ec1u ch\u1ec9nh con \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u protein kinase\/glycogen synthase kinase-3\u03b2 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t b\u1edfi adenylate, do \u0111\u00f3 c\u00f3 t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 th\u1ea7n kinh ch\u1ed1ng CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib193\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib193\"><span class=\"anchor-text\">[193]<\/span><\/a>. C\u00e1c th\u1ee5 th\u1ec3 lipoprotein m\u1eadt \u0111\u1ed9 th\u1ea5p c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf ch\u1ee9ng pyroptosis t\u1ebf b\u00e0o th\u1ea7n kinh qua trung gian NLRP3 sau CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib194\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib194\"><span class=\"anchor-text\">[194]<\/span><\/a>. Th\u1ee5 th\u1ec3 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t b\u1edfi ch\u1ea5t t\u0103ng sinh peroxisome qua trung gian r\u01b0\u1ee3u lipid \u03b1-glutamate oxaloacetate transaminase 1 tr\u1ee5c c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf qu\u00e1 tr\u00ecnh pyroptosis c\u1ee7a c\u00e1c t\u1ebf b\u00e0o n\u1ed9i m\u00f4 sau IS v\u00e0 c\u1ea3i thi\u1ec7n ch\u1ea5n th\u01b0\u01a1ng n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib195\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib195\"><span class=\"anchor-text\">[195]<\/span><\/a>. S\u1ef1 bi\u1ec3u hi\u1ec7n qu\u00e1 m\u1ee9c c\u1ee7a CHRFAM7A c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf b\u1ec7nh pyroptosis vi m\u00f4 ph\u1ee5 thu\u1ed9c v\u00e0o con \u0111\u01b0\u1eddng NLRP3 \/ caspase-1 v\u00e0 l\u00e0m gi\u1ea3m CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib196\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib196\"><span class=\"anchor-text\">[196]<\/span><\/a>. C\u00e1c ch\u1ea5t \u0111i\u1ec1u h\u00f2a glycolysis v\u00e0 apoptosis do TP53 g\u00e2y ra c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m ch\u1ee9ng pyroptosis vi m\u00f4 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 n\u00e3o v\u00e0 ch\u1ea5n th\u01b0\u01a1ng n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib197\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib197\"><span class=\"anchor-text\">[197]<\/span><\/a>. Ngo\u00e0i ra,\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 exosome t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/exosome\">exosome<\/a>\u00a0c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb t\u1ee7y x\u01b0\u01a1ng thi\u1ebfu oxy\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mesenchymal-stem-cell\">t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4<\/a>\u00a0c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh ki\u1ec3u h\u00ecnh M1\/M2 microglial \u0111\u1ec3 l\u00e0m gi\u1ea3m ch\u1ee9ng pyroptosis t\u1ebf b\u00e0o th\u1ea7n kinh do CIRI g\u00e2y ra\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib198\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib198\"><span class=\"anchor-text\">[198]<\/span><\/a>. Thi\u1ebfu oxy ti\u1ec1n \u0111i\u1ec1u ki\u1ec7n\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 ni\u00eam m\u1ea1c kh\u1ee9u gi\u00e1c t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/olfactory-mucosa\">ni\u00eam m\u1ea1c kh\u1ee9u gi\u00e1c<\/a>\u00a0T\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf qu\u00e1 tr\u00ecnh pyroptosis v\u00e0 apoptosis c\u1ee7a microglia g\u00e2y ra b\u1edfi thi\u1ebfu m\u00e1u n\u00e3o b\u1eb1ng c\u00e1ch k\u00edch ho\u1ea1t y\u1ebfu t\u1ed1 thi\u1ebfu oxy-c\u1ea3m \u1ee9ng-1\u03b1, do \u0111\u00f3 l\u00e0m gi\u1ea3m CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib199\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib199\"><span class=\"anchor-text\">[199]<\/span><\/a>.<\/p>\n<p id=\"p0145\">L\u00e0 ng\u01b0\u1eddi th\u1ef1c hi\u1ec7n b\u1ec7nh pyroptosis, GSDMD l\u00e0 m\u1ee5c ti\u00eau ph\u00e2n t\u1eed l\u00fd t\u01b0\u1edfng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb IS. Tuy nhi\u00ean, nghi\u00ean c\u1ee9u hi\u1ec7n t\u1ea1i v\u1ec1 thu\u1ed1c \u1ee9c ch\u1ebf GSDMD v\u1eabn c\u00f2n \u1edf giai \u0111o\u1ea1n s\u01a1 khai v\u00e0 c\u00f2n thi\u1ebfu b\u1eb1ng ch\u1ee9ng v\u1ec1 hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c \u1ee9c ch\u1ebf GSDMD trong \u0111i\u1ec1u tr\u1ecb \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9. C\u00e1c nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng m\u1ed9t s\u1ed1 th\u00e0nh ph\u1ea7n th\u1ef1c v\u1eadt t\u1ef1 nhi\u00ean c\u00f3 th\u1ec3 \u0111i\u1ec1u tr\u1ecb IS b\u1eb1ng c\u00e1ch \u0111i\u1ec1u ch\u1ec9nh con \u0111\u01b0\u1eddng pyroptotic.<\/p>\n<\/section>\n<section id=\"sec0095\">\n<h2 id=\"sect0115\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">5. C\u00e1c s\u1ea3n ph\u1ea9m t\u1ef1 nhi\u00ean l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf pyroptosis m\u1edbi v\u00e0 do \u0111\u00f3 tr\u1edf th\u00e0nh \u1ee9ng c\u1eed vi\u00ean ti\u1ec1m n\u0103ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb IS<\/h2>\n<p id=\"p0150\">S\u1ea3n ph\u1ea9m t\u1eeb thi\u00ean nhi\u00ean c\u00f3 \u01b0u \u0111i\u1ec3m v\u01b0\u1ee3t tr\u1ed9i trong ph\u00f2ng ng\u1eeba v\u00e0 \u0111i\u1ec1u tr\u1ecb nh\u1ed3i m\u00e1u n\u00e3o\/thi\u1ebfu m\u00e1u n\u00e3o t\u00e1i t\u01b0\u1edbi m\u00e1u do \u01b0u \u0111i\u1ec3m \u0111a th\u00e0nh ph\u1ea7n, \u0111a m\u1ee5c ti\u00eau, \u0111a k\u00eanh, \u00edt \u0111\u1ed9c t\u00ednh v\u00e0 c\u00f3 tri\u1ec3n v\u1ecdng \u1ee9ng d\u1ee5ng t\u1ed1t. Hi\u1ec7n nay, vi\u1ec7c nghi\u00ean c\u1ee9u c\u00e1c s\u1ea3n ph\u1ea9m t\u1ef1 nhi\u00ean trong ph\u00f2ng ng\u1eeba v\u00e0 \u0111i\u1ec1u tr\u1ecb nh\u1ed3i m\u00e1u n\u00e3o\/CIRI \u0111ang d\u1ea7n \u0111\u01b0\u1ee3c gia t\u0103ng, li\u00ean quan \u0111\u1ebfn nhi\u1ec1u c\u01a1 ch\u1ebf b\u1ea3o v\u1ec7 kh\u00e1c nhau. Ph\u1ea7n n\u00e0y t\u00f3m t\u1eaft c\u00e1c s\u1ea3n ph\u1ea9m t\u1ef1 nhi\u00ean, m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt ho\u1eb7c t\u1ebf b\u00e0o, ph\u01b0\u01a1ng ph\u00e1p s\u1eed d\u1ee5ng, li\u1ec1u d\u00f9ng, th\u1eddi gian \u0111i\u1ec1u tr\u1ecb, t\u00e1c d\u1ee5ng v\u00e0 c\u01a1 ch\u1ebf \u0111i\u1ec1u tr\u1ecb (con \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u) \u0111\u1ec3 cung c\u1ea5p h\u1ed7 tr\u1ee3 v\u1ec1 m\u1eb7t l\u00fd thuy\u1ebft cho vi\u1ec7c t\u00ecm ki\u1ebfm nhanh ch\u00f3ng c\u00e1c th\u00e0nh ph\u1ea7n th\u1ef1c v\u1eadt t\u1ef1 nhi\u00ean an to\u00e0n, hi\u1ec7u qu\u1ea3, \u00edt \u0111\u1ed9c t\u00ednh. v\u00e0 \u0111i\u1ec1u ch\u1ec9nh b\u1ec7nh pyroptosis \u0111\u1ec3 ph\u00f2ng ng\u1eeba v\u00e0 \u0111i\u1ec1u tr\u1ecb IS\/CIRI.<\/p>\n<section id=\"sec0100\">\n<h3 id=\"sect0120\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">5.1. Th\u00e0nh ph\u1ea7n th\u1ef1c v\u1eadt t\u1ef1 nhi\u00ean<\/h3>\n<div>\n<p id=\"p0155\">C\u1ea5u tr\u00fac ch\u00ednh c\u1ee7a c\u00e1c th\u00e0nh ph\u1ea7n th\u1ef1c v\u1eadt t\u1ef1 nhi\u00ean \u0111\u01b0\u1ee3c th\u1ec3 hi\u1ec7n \u1edf\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#fig0015\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"fig0015\"><span class=\"anchor-text\">H\u00ecnh 3<\/span><\/a>.<\/p>\n<figure id=\"fig0015\" class=\"figure text-xs\"><img decoding=\"async\" src=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr3.jpg\" alt=\"Fig. 3\" height=\"397\" aria-describedby=\"cap0015\" \/><\/p>\n<ol class=\"u-margin-s-bottom\">\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"T\u1ea3i xu\u1ed1ng h\u00ecnh \u1ea3nh c\u00f3 \u0111\u1ed9 ph\u00e2n gi\u1ea3i cao (208KB)\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr3_lrg.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">T\u1ea3i xu\u1ed1ng :\u00a0<span class=\"download-link-title\">T\u1ea3i xu\u1ed1ng h\u00ecnh \u1ea3nh c\u00f3 \u0111\u1ed9 ph\u00e2n gi\u1ea3i cao (208KB)<\/span><\/span><\/a><\/li>\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"T\u1ea3i xu\u1ed1ng h\u00ecnh \u1ea3nh k\u00edch th\u01b0\u1edbc \u0111\u1ea7y \u0111\u1ee7\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr3.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">T\u1ea3i xu\u1ed1ng :\u00a0<span class=\"download-link-title\">T\u1ea3i xu\u1ed1ng h\u00ecnh \u1ea3nh k\u00edch th\u01b0\u1edbc \u0111\u1ea7y \u0111\u1ee7<\/span><\/span><\/a><\/li>\n<\/ol>\n<p id=\"sp0015\"><span class=\"label\">H\u00ecnh 3<\/span>. C\u1ea5u tr\u00fac ch\u00ednh c\u1ee7a c\u00e1c th\u00e0nh ph\u1ea7n th\u1ef1c v\u1eadt t\u1ef1 nhi\u00ean.<\/p>\n<\/figure>\n<\/div>\n<section id=\"sec0105\">\n<h4 id=\"sect0125\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.1. Gastrodin (GAS)<\/h4>\n<p id=\"p0160\">GAS l\u00e0 m\u1ed9t h\u1ee3p ch\u1ea5t \u0111a ch\u1ee9c n\u0103ng c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb th\u1ea3o m\u1ed9c,\u00a0<em><a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Gastrodia elata t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/gastrodia-elata\">d\u1ea1 d\u00e0y ru\u1ed9t<\/a><\/em>, v\u1edbi nhi\u1ec1u lo\u1ea1i\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c ho\u1ea1t \u0111\u1ed9ng d\u01b0\u1ee3c l\u00fd t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/pharmacological-activity\">ho\u1ea1t \u0111\u1ed9ng d\u01b0\u1ee3c l\u00fd<\/a>, ch\u1eb3ng h\u1ea1n nh\u01b0 c\u00e1c ho\u1ea1t \u0111\u1ed9ng ch\u1ed1ng oxy h\u00f3a v\u00e0 ch\u1ed1ng vi\u00eam. Ngo\u00e0i ra, GAS \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 c\u00e1c tri\u1ec7u ch\u1ee9ng t\u00e1i t\u01b0\u1edbi m\u00e1u n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 b\u1eb1ng c\u00e1ch \u0111i\u1ec1u ch\u1ec9nh c\u00e1c y\u1ebfu t\u1ed1 g\u00e2y apoptotic bao g\u1ed3m s\u1ef1 ph\u00e2n c\u1eaft caspase-3, IL-18 v\u00e0 IL-1\u03b2. M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng GAS c\u1ea3i thi\u1ec7n ch\u1ea5n th\u01b0\u01a1ng do thi\u1ebfu m\u00e1u n\u00e3o v\u00e0 l\u00e0m gi\u1ea3m m\u1ee9c \u0111\u1ed9\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c lo\u1ea1i oxy ph\u1ea3n \u1ee9ng t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/reactive-oxygen-species\">c\u00e1c lo\u1ea1i oxy ph\u1ea3n \u1ee9ng<\/a>\u00a0V\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c cytokine g\u00e2y vi\u00eam t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammatory-cytokine\">cytokine g\u00e2y vi\u00eam<\/a>\u00a0\u1edf chu\u1ed9t\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib200\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib200\"><span class=\"anchor-text\">[200]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib201\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib201\"><span class=\"anchor-text\">[201]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib202\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib202\"><span class=\"anchor-text\">[202]<\/span><\/a>. Lu v\u00e0 c\u1ed9ng s\u1ef1. ph\u00e1t hi\u1ec7n ra r\u1eb1ng GAS c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n t\u00ecnh tr\u1ea1ng pyroptosis li\u00ean quan \u0111\u1ebfn t\u1ed5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 vi m\u1ea1ch tim b\u1eb1ng c\u00e1ch nh\u1eafm m\u1ee5c ti\u00eau v\u00e0o tr\u1ee5c NLRP3 \/ caspase-1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib203\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib203\"><span class=\"anchor-text\">[203]<\/span><\/a>. GAS c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n \u0111\u00e1ng k\u1ec3\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 ch\u1ee9c n\u0103ng th\u1ea7n kinh t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nervous-system-physiology\">ch\u1ee9c n\u0103ng th\u1ea7n kinh<\/a>\u00a0ghi \u0111i\u1ec3m v\u00e0 gi\u1ea3m k\u00edch th\u01b0\u1edbc c\u1ee7a\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 nh\u1ed3i m\u00e1u n\u00e3o t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-infarction\">nh\u1ed3i m\u00e1u n\u00e3o<\/a>. Trong khi \u0111\u00f3, GAS \u1ee9c ch\u1ebf ch\u1ee9ng pyroptosis b\u1eb1ng c\u00e1ch \u0111i\u1ec1u h\u00f2a gi\u1ea3m NLRP3, c\u00e1c y\u1ebfu t\u1ed1 g\u00e2y vi\u00eam (IL-1\u03b2, IL-18) v\u00e0 t\u00e1ch caspase-1. H\u01a1n n\u1eefa, GAS l\u00e0m gi\u1ea3m t\u00ecnh tr\u1ea1ng vi\u00eam t\u1ebf b\u00e0o th\u1ea7n kinh do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 do t\u00e1i t\u01b0\u1edbi m\u00e1u b\u1eb1ng c\u00e1ch \u0111i\u1ec1u ch\u1ec9nh tr\u1ee5c lncRNA NEAT1 \/ miR-22\u20133p. GAS l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 t\u1ed5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 b\u1eb1ng c\u00e1ch \u0111i\u1ec1u ch\u1ec9nh tr\u1ee5c lncRNA NEAT1 \/ miR-22\u20133p\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib204\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib204\"><span class=\"anchor-text\">[204]<\/span><\/a>. V\u00ec v\u1eady, GAS c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nh\u01b0 m\u1ed9t ngu\u1ed3n ti\u1ec1m n\u0103ng\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 thu\u1ed1c t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chemotherapeutic-agent\">thu\u1ed1c<\/a>\u00a0\u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb CIRI.<\/p>\n<\/section>\n<section id=\"sec0110\">\n<h4 id=\"sect0130\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.2. Tanshinon IIA<\/h4>\n<p id=\"p0165\"><a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Tanshinone IIA t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tanshinone-iia\">Tanshinon IIA<\/a>\u00a0l\u00e0 th\u00e0nh ph\u1ea7n ho\u1ea1t \u0111\u1ed9ng ch\u00ednh c\u1ee7a\u00a0<em><a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Salvia miltiorrhiza t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/salvia-miltiorrhiza\">Salvia miltiorrhiza<\/a><\/em>. N\u00f3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh tim m\u1ea1ch v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c b\u1ec7nh m\u1ea1ch m\u00e1u n\u00e3o t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebrovascular-disease\">b\u1ec7nh m\u1ea1ch m\u00e1u n\u00e3o<\/a>\u00a0do t\u00e1c d\u1ee5ng ch\u1ed1ng oxy h\u00f3a v\u00e0 c\u1ea3i thi\u1ec7n tu\u1ea7n ho\u00e0n c\u1ee7a n\u00f3. Cai v\u00e0 c\u1ed9ng s\u1ef1.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib205\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib205\"><span class=\"anchor-text\">[205]<\/span><\/a>\u00a0ph\u00e1t hi\u1ec7n ra r\u1eb1ng tanshinone IIA l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 s\u1ef1 bi\u1ec3u hi\u1ec7n IL-1\u03b2 v\u00e0 IL-18 trong con \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u vi\u00eam NLRP3 v\u00e0 t\u00e1c d\u1ee5ng c\u1ee7a n\u00f3 ph\u1ee5 thu\u1ed9c v\u00e0o li\u1ec1u l\u01b0\u1ee3ng. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y tanshinone IIA \u1ee9c ch\u1ebf s\u1ef1 k\u00edch ho\u1ea1t \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u NLRP3, do \u0111\u00f3 l\u00e0m gi\u1ea3m t\u1ed5n th\u01b0\u01a1ng do thi\u1ebfu h\u1ee5t oxy-glucose\/t\u00e1i t\u01b0\u1edbi m\u00e1u tr\u00ean t\u1ebf b\u00e0o BV-2 sau \u0111\u1ed9t qu\u1ef5.<\/p>\n<\/section>\n<section id=\"sec0115\">\n<h4 id=\"sect0135\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.3. Leonurine<\/h4>\n<p id=\"p0170\"><a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Leonurine t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/leonurine\">Leonurine<\/a>\u00a0TRONG\u00a0<em><a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Leonuri t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/leonurus\">Leonuri<\/a><\/em><em>\u00a0th\u1ea3o m\u1ed9c<\/em>\u00a0c\u1ea3i thi\u1ec7n kh\u1ea3 n\u0103ng h\u1ecdc t\u1eadp v\u00e0 kh\u1ea3 n\u0103ng ghi nh\u1edb c\u1ee7a chu\u1ed9t b\u1ecb thi\u1ebfu m\u00e1u n\u00e3o m\u00e3n t\u00ednh v\u00e0 gi\u1ea3m bi\u1ec3u hi\u1ec7n NLRP3. Ng\u01b0\u1eddi ta suy \u0111o\u00e1n r\u1eb1ng m\u1ee5c \u0111\u00edch b\u1ea3o v\u1ec7 d\u00e2y th\u1ea7n kinh c\u00f3 th\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c th\u00f4ng qua t\u00e1c d\u1ee5ng ch\u1ed1ng vi\u00eam. Vi\u1ec7c k\u00edch ho\u1ea1t NLRP3 \u0111\u00e3 th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh chuy\u1ec3n \u0111\u1ed5i ti\u1ec1n ch\u1ea5t Caspase-1 th\u00e0nh Caspase-1 v\u00e0 th\u00fac \u0111\u1ea9y s\u1ea3n xu\u1ea5t IL-1\u03b2 v\u00e0 IL-18, do \u0111\u00f3 g\u00e2y ra m\u1ed9t lo\u1ea1t ph\u1ea3n \u1ee9ng vi\u00eam. Leonurine c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m ph\u1ea3n \u1ee9ng vi\u00eam trong m\u00f4 n\u00e3o, gi\u1ea3m \u0111i\u1ec3m th\u00e2m h\u1ee5t th\u1ea7n kinh b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf qu\u00e1 tr\u00ecnh pyroptosis c\u1ee7a t\u1ebf b\u00e0o v\u00e0 c\u00f3 t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 th\u1ea7n kinh t\u1ed1t\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib206\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib206\"><span class=\"anchor-text\">[206]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0120\">\n<h4 id=\"sect0140\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.4. Paeoniflorin<\/h4>\n<p id=\"p0175\"><a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Paeoniflorin t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/paeoniflorin\">Paeoniflorin<\/a>\u00a0xu\u1ea5t ph\u00e1t t\u1eeb th\u00e0nh ph\u1ea7n ch\u00ednh c\u1ee7a\u00a0<em><a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Paeoniae radix rubra t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/radix-paeoniae-rubra\">Paeoniae c\u01a1 s\u1ed1 rubra<\/a><\/em>. Paeoniflorin l\u00e0 th\u00e0nh ph\u1ea7n ho\u1ea1t ch\u1ea5t ch\u00ednh trong t\u1ed5ng s\u1ed1 glucoside c\u1ee7a\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 hoa m\u1eabu \u0111\u01a1n t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/paeonia\">m\u1eabu \u0111\u01a1n<\/a>\u00a0(TGP), c\u0169ng c\u00f3 ho\u1ea1t t\u00ednh ch\u1ed1ng vi\u00eam v\u00e0 \u0111i\u1ec1u h\u00f2a mi\u1ec5n d\u1ecbch t\u1ed1t\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib207\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib207\"><span class=\"anchor-text\">[207]<\/span><\/a>. TGP v\u00e0 paeoniflorin c\u0169ng c\u00f3 nhi\u1ec1u ho\u1ea1t t\u00ednh d\u01b0\u1ee3c l\u00fd kh\u00e1c nhau nh\u01b0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 thu\u1ed1c ch\u1ed1ng co th\u1eaft t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antispasmodic\">ch\u1ed1ng co th\u1eaft<\/a>,\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 thu\u1ed1c gi\u1ea3m \u0111au t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/anodyne\">thu\u1ed1c gi\u1ea3m \u0111au<\/a>, V\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 s\u1ef1 gi\u00e3n m\u1ea1ch t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vasodilatation\">s\u1ef1 gi\u00e3n m\u1ea1ch<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib208\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib208\"><span class=\"anchor-text\">[208]<\/span><\/a>. Zulifiya Ekemu v\u00e0 c\u1ed9ng s\u1ef1. ph\u00e1t hi\u1ec7n ra r\u1eb1ng sau khi t\u00e1i t\u01b0\u1edbi m\u00e1u n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 c\u1ea5p t\u00ednh, vi\u1ec7c k\u00edch ho\u1ea1t microglia v\u00e0 ch\u1ee9ng pyroptosis t\u1ebf b\u00e0o th\u1ea7n kinh trong n\u00e3o l\u00e0 r\u00f5 r\u00e0ng, vi\u1ec7c k\u00edch ho\u1ea1t NLRP3 \u0111\u00e3 t\u0103ng l\u00ean v\u00e0 Caspase-1 v\u00e0 IL-1\u03b2 \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh t\u0103ng\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib209\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib209\"><span class=\"anchor-text\">[209]<\/span><\/a>. Paeoniflorin l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 \u0111i\u1ec3m ch\u1ee9c n\u0103ng th\u1ea7n kinh, gi\u1ea3m \u0111\u00e1ng k\u1ec3\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 k\u00edch th\u01b0\u1edbc nh\u1ed3i m\u00e1u n\u00e3o t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-infarction-size\">k\u00edch th\u01b0\u1edbc nh\u1ed3i m\u00e1u n\u00e3o<\/a>, bi\u1ec3u hi\u1ec7n Iba1 \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3m \u0111\u00e1ng k\u1ec3 v\u00e0 t\u00ecnh tr\u1ea1ng t\u1ebf b\u00e0o th\u1ea7n kinh \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n \u0111\u00e1ng k\u1ec3. Ngo\u00e0i ra, c\u00e1c bi\u1ec3u hi\u1ec7n c\u1ee7a NLRP3, Caspase-1 v\u00e0 IL-1\u03b2 \u0111\u00e3 gi\u1ea3m \u0111\u00e1ng k\u1ec3 sau khi can thi\u1ec7p b\u1eb1ng paeoniflorin. C\u00f3 \u00fd ki\u1ebfn cho r\u1eb1ng paeoniflorin c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m s\u1ef1 k\u00edch ho\u1ea1t c\u1ee7a microglia, \u1ee9c ch\u1ebf ch\u1ee9ng pyroptosis t\u1ebf b\u00e0o th\u1ea7n kinh v\u00e0 c\u1ea3i thi\u1ec7n t\u1ed5n th\u01b0\u01a1ng th\u1ea7n kinh qua trung gian ACI b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf s\u1ef1 k\u00edch ho\u1ea1t NLRP3 v\u00e0 Caspase-1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib209\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib209\"><span class=\"anchor-text\">[209]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0125\">\n<h4 id=\"sect0145\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.5. Butylphtalit<\/h4>\n<p id=\"p0180\"><span class=\"small-caps\">L<\/span>-butylphthalide l\u1ea7n \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp t\u1eeb h\u1ea1t c\u1ea3i xoong v\u00e0 sau \u0111\u00f3 n\u00f3 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c t\u1ed5ng h\u1ee3p m\u1ed9t c\u00e1ch nh\u00e2n t\u1ea1o.\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Butylphthalide t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/butylphthalide\">Butylphtalit<\/a>\u00a0c\u00f3 m\u1ed9t vai tr\u00f2 k\u00e9p duy nh\u1ea5t, kh\u00f4ng ch\u1ec9 c\u00f3 th\u1ec3 t\u00e1i t\u1ea1o l\u1ea1i\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 vi tu\u1ea7n ho\u00e0n t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microcirculation\">vi tu\u1ea7n ho\u00e0n<\/a>\u00a0v\u00e0 t\u0103ng c\u01b0\u1eddng t\u00e1i t\u01b0\u1edbi m\u00e1u do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9, t\u1eeb \u0111\u00f3 b\u1ea3o v\u1ec7 t\u00ednh to\u00e0n v\u1eb9n c\u1ee7a\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u1ea5u tr\u00fac m\u1ea1ch m\u00e1u t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/blood-vessel\">c\u1ea5u tr\u00fac m\u1ea1ch m\u00e1u<\/a>, ph\u1ee5c h\u1ed3i \u0111\u01b0\u1eddng k\u00ednh m\u1ea1ch m\u00e1u, t\u0103ng l\u01b0u l\u01b0\u1ee3ng m\u00e1u \u1edf v\u00f9ng thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 v\u00e0 s\u1ed1 l\u01b0\u1ee3ng xung quanh\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c vi m\u1ea1ch t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microvessel\">vi m\u1ea1ch<\/a>, m\u00e0 c\u00f2n b\u1ea3o v\u1ec7 ty th\u1ec3 v\u00e0 gi\u1ea3m s\u1ef1 ch\u1ebft c\u1ee7a t\u1ebf b\u00e0o, t\u1eeb \u0111\u00f3 b\u1ea3o v\u1ec7 t\u00ednh to\u00e0n v\u1eb9n c\u1ee7a c\u1ea5u tr\u00fac ty th\u1ec3, c\u1ea3i thi\u1ec7n ho\u1ea1t \u0111\u1ed9ng c\u1ee7a enzyme ph\u1ee9c h\u1ee3p ty th\u1ec3 IV, c\u1ea3i thi\u1ec7n ho\u1ea1t \u0111\u1ed9ng c\u1ee7a enzyme ATP c\u1ee7a ty th\u1ec3 v\u00e0 duy tr\u00ec s\u1ef1 \u1ed5n \u0111\u1ecbnh c\u1ee7a\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 m\u00e0ng ty th\u1ec3 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitochondrial-membrane\">m\u00e0ng ty th\u1ec3<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib210\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib210\"><span class=\"anchor-text\">[210]<\/span><\/a>. Nghi\u00ean c\u1ee9u m\u1edbi nh\u1ea5t cho th\u1ea5y butylphthalide c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ch\u1ee9ng pyroptosis \u1edf chu\u1ed9t CIRI theo c\u00e1ch ph\u1ee5 thu\u1ed9c v\u00e0o li\u1ec1u l\u01b0\u1ee3ng th\u00f4ng qua con \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u h\u1ed3ng c\u1ea7u NLRP3.<\/p>\n<\/section>\n<section id=\"sec0130\">\n<h4 id=\"sect0150\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.6. Breviscapine<\/h4>\n<p id=\"p0185\"><a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Breviscapine t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/breviscapine\">Breviscapine<\/a>\u00a0\u0111\u01b0\u1ee3c chi\u1ebft xu\u1ea5t t\u1eeb\u00a0<em><a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Erigeron breviscapus t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/erigeron-breviscapus\">Erigeron breviscapus<\/a><\/em>\u00a0(Vant.) Tay. -Mazz. Breviscapine l\u00e0 h\u1ed7n h\u1ee3p c\u1ee7a\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 scutellarin t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/scutellarin\">scutellarin<\/a>\u00a0ch\u1ee7 y\u1ebfu ch\u1ee9a scutellarin v\u1edbi m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf scutellarin, c\u00f3 t\u00e1c d\u1ee5ng l\u00e0m gi\u00e3n m\u1ea1ch m\u00e1u n\u00e3o, gi\u1ea3m s\u1ee9c c\u1ea3n m\u1ea1ch m\u00e1u n\u00e3o, t\u0103ng l\u01b0u l\u01b0\u1ee3ng m\u00e1u n\u00e3o, c\u1ea3i thi\u1ec7n vi tu\u1ea7n ho\u00e0n, ch\u1ed1ng l\u1ea1i b\u1ec7nh t\u1eadt.\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 s\u1ef1 k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/thrombocyte-aggregation\">k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u<\/a>. Nghi\u00ean c\u1ee9u m\u1edbi nh\u1ea5t cho th\u1ea5y breviscapine \u1ee9c ch\u1ebf \u0111\u00e1ng k\u1ec3 s\u1ef1 k\u00edch ho\u1ea1t c\u00e1c t\u1ebf b\u00e0o vi\u00eam NLRP3 trong c\u01a1 th\u1ec3.\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 h\u1ea3i m\u00e3 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hippocampus\">h\u1ed3i h\u1ea3i m\u00e3<\/a>\u00a0c\u1ee7a chu\u1ed9t CCI, \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3m s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a protein Caspase 1, IL-6 v\u00e0 IL-1\u03b2, \u1ee9c ch\u1ebf s\u1ef1 k\u00edch ho\u1ea1t protein Caspase-3 v\u00e0 \u1ee9c ch\u1ebf\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 qu\u00e1 tr\u00ecnh t\u1ef1 h\u1ee7y t\u1ebf b\u00e0o th\u1ea7n kinh t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroapoptosis\">apoptosis th\u1ea7n kinh<\/a>. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y r\u1eb1ng breviscapine c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n \u0111\u00e1ng k\u1ec3 ch\u1ee9c n\u0103ng nh\u1eadn th\u1ee9c c\u1ee7a chu\u1ed9t CCI v\u00e0 gi\u1ea3m t\u1ed5n th\u01b0\u01a1ng b\u1ec7nh l\u00fd c\u1ee7a c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9, v\u00e0 c\u01a1 ch\u1ebf c\u1ee7a n\u00f3 c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c \u1ee9c ch\u1ebf qu\u00e1 tr\u00ecnh k\u00edch ho\u1ea1t h\u1ed3ng c\u1ea7u NLRP3 v\u00e0 con \u0111\u01b0\u1eddng pyroptosis trong m\u00f4 n\u00e3o\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib211\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib211\"><span class=\"anchor-text\">[211]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0135\">\n<h4 id=\"sect0155\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.7. Resveratrol<\/h4>\n<p id=\"p0190\"><a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Resveratrol t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/resveratrol\">Resveratrol<\/a>\u00a0l\u00e0 m\u1ed9t ch\u1ea5t kh\u00f4ng ch\u1ee9a flavonoid\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 h\u1ee3p ch\u1ea5t polyphenolic t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/polyphenol-derivative\">h\u1ee3p ch\u1ea5t polyphenolic<\/a>. N\u00f3 l\u1ea7n \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp t\u1eeb r\u1ec5 c\u1ee7a\u00a0<em><a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Veratrum t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/veratrum\">Veratrum<\/a><\/em><em>\u00a0hoa lan<\/em>v\u00e0 resveratrol \u0111\u00e3 \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y \u1edf h\u01a1n 700 lo\u1ea1i th\u1ef1c v\u1eadt. C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng resveratrol \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh stress oxy h\u00f3a trong nh\u1ed3i m\u00e1u n\u00e3o, \u1ee9c ch\u1ebf vi\u00eam v\u00e0 c\u1ea3i thi\u1ec7n tr\u00ed n\u00e3o.\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 b\u1ea3o v\u1ec7 th\u1ea7n kinh t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroprotection\">b\u1ea3o v\u1ec7 th\u1ea7n kinh<\/a>. Resveratrol \u0111i\u1ec1u ch\u1ec9nh qu\u00e1 tr\u00ecnh pyroptosis c\u1ee7a m\u00f4 n\u00e3o t\u00e1i t\u01b0\u1edbi m\u00e1u do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 ch\u1ee7 y\u1ebfu th\u00f4ng qua vi\u1ec7c \u0111i\u1ec1u h\u00f2a microglia NLRP3 inflammasome, Caspase-1 v\u00e0 ZO-1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib212\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib212\"><span class=\"anchor-text\">[212]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0140\">\n<h4 id=\"sect0160\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.8. Axit Salvianolic (SAFI)<\/h4>\n<p id=\"p0195\">C\u00e1c nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng SAFI l\u00e0m t\u0103ng \u0111\u00e1ng k\u1ec3 \u0111i\u1ec3m th\u00e2m h\u1ee5t th\u1ea7n kinh, gi\u1ea3m th\u1ec3 t\u00edch v\u00f9ng nh\u1ed3i m\u00e1u, l\u00e0m gi\u1ea3m t\u1ed5n th\u01b0\u01a1ng m\u00f4 h\u1ecdc \u0111\u1ed1i v\u1edbi\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 v\u1ecf n\u00e3o t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebral-cortex\">v\u1ecf n\u00e3o<\/a>\u00a0v\u00e0 apoptosis t\u1ebf b\u00e0o th\u1ea7n kinh trong m\u00f4 h\u00ecnh MCAO\/R, t\u0103ng kh\u1ea3 n\u0103ng t\u1ed3n t\u1ea1i c\u1ee7a t\u1ebf b\u00e0o th\u1ea7n kinh v\u00e0 gi\u1ea3m qu\u00e1 tr\u00ecnh apoptosis c\u1ee7a t\u1ebf b\u00e0o th\u1ea7n kinh trong m\u00f4 h\u00ecnh OGD. SAFI c\u0169ng \u0111\u00e3 \u0111i\u1ec1u ch\u1ec9nh l\u1ea1i ki\u1ec3u ph\u00e2n c\u1ef1c vi m\u00f4 t\u1eeb ki\u1ec3u h\u00ecnh gi\u1ed1ng M1 sang ki\u1ec3u h\u00ecnh gi\u1ed1ng M2 v\u00e0 \u1ee9c ch\u1ebf s\u1ef1 k\u00edch ho\u1ea1t c\u1ee7a d\u00f2ng h\u1ed3ng c\u1ea7u NLRP3 v\u00e0 s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a c\u00e1c protein li\u00ean quan \u0111\u1ebfn h\u1ed3ng c\u1ea7u\/pyroxia NLRP3 trong \u1ed1ng nghi\u1ec7m v\u00e0 in vivo. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y SAFI c\u00f3 th\u1ec3 ph\u00e1t huy t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 th\u1ea7n kinh b\u1eb1ng c\u00e1ch gi\u1ea3m qu\u00e1 tr\u00ecnh apoptosis c\u1ee7a t\u1ebf b\u00e0o th\u1ea7n kinh, chuy\u1ec3n ki\u1ec3u h\u00ecnh vi m\u00f4 t\u1eeb M1 sang M2 v\u00e0 \u1ee9c ch\u1ebf tr\u1ee5c h\u1ed3ng c\u1ea7u\/pyroptotic NLRP3 trong microglia\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib213\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib213\"><span class=\"anchor-text\">[213]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0145\">\n<h4 id=\"sect0165\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.9. Hispidulin<\/h4>\n<p id=\"p0200\"><a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Hispidulin t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hispidulin\">Hispidulin<\/a>\u00a0l\u00e0 m\u1ed9t\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 flavonoid t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/flavonoid\">flavonoid<\/a>\u00a0h\u1ee3p ch\u1ea5t c\u00f3 nhi\u1ec1u \u0111\u1eb7c t\u00ednh d\u01b0\u1ee3c l\u00fd kh\u00e1c nhau v\u00e0 l\u00e0 m\u1ed9t trong nh\u1eefng th\u00e0nh ph\u1ea7n ho\u1ea1t \u0111\u1ed9ng ch\u00ednh c\u1ee7a nhi\u1ec1u lo\u1ea1i\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c lo\u1ea1i thu\u1ed1c th\u1ea3o d\u01b0\u1ee3c Trung Qu\u1ed1c t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chinese-herbal-medicine\">Thu\u1ed1c th\u1ea3o d\u01b0\u1ee3c Trung Qu\u1ed1c<\/a>. Hispidulin c\u00f3 nhi\u1ec1u \u0111\u1eb7c t\u00ednh d\u01b0\u1ee3c l\u00fd, bao g\u1ed3m ch\u1ea5t ch\u1ed1ng oxy h\u00f3a,\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 thu\u1ed1c ch\u1ed1ng n\u1ea5m t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antifungal-agent\">thu\u1ed1c ch\u1ed1ng n\u1ea5m<\/a>,\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 thu\u1ed1c ch\u1ed1ng ung th\u01b0 t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/anticarcinogen\">ch\u1ed1ng ung th\u01b0<\/a>, \u0111\u1eb7c t\u00ednh ch\u1ed1ng lo\u00e3ng x\u01b0\u01a1ng, ch\u1ed1ng vi\u00eam v\u00e0 ch\u1ed1ng \u0111\u1ed9t bi\u1ebfn. Nghi\u00ean c\u1ee9u m\u1edbi nh\u1ea5t cho th\u1ea5y Hispidulin \u0111\u00e3 c\u1ea3i thi\u1ec7n\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c tri\u1ec7u ch\u1ee9ng th\u1ea7n kinh t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neurologic-disease\">tri\u1ec7u ch\u1ee9ng th\u1ea7n kinh<\/a>\u00a0\u1edf chu\u1ed9t sau IRI, \u0111\u1ed3ng th\u1eddi gi\u1ea3m k\u00edch th\u01b0\u1edbc v\u00f9ng nh\u1ed3i m\u00e1u v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 ch\u1ee9ng ph\u00f9 n\u00e3o t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-edema\">ph\u00f9 n\u00e3o<\/a>. V\u1ec1 m\u1eb7t c\u01a1 h\u1ecdc, herpidulin ph\u00e1t huy t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 th\u1ea7n kinh in vivo v\u00e0 in vitro b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf b\u1ec7nh pyroptosis qua trung gian NLRP3 b\u1eb1ng c\u00e1ch \u0111i\u1ec1u ch\u1ec9nh \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u AMPK\/GSK3\u03b2\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib214\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib214\"><span class=\"anchor-text\">[214]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0150\">\n<h4 id=\"sect0170\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.10. Astragaloside IV<\/h4>\n<p id=\"p0205\"><em><a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Astragali Radix t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/astragalus-root\">C\u01a1 s\u1ed1 x\u01b0\u01a1ng c\u1ef1a<\/a><\/em>\u00a0C\u00f3 th\u1ec3 b\u1ed5 sung s\u1ef1 thi\u1ebfu h\u1ee5t, c\u1ee7ng c\u1ed1 l\u00e1 l\u00e1ch v\u00e0 d\u1ea1 d\u00e0y, th\u00fac \u0111\u1ea9y l\u01b0u th\u00f4ng m\u00e1u v\u00e0 th\u00fac \u0111\u1ea9y l\u01b0u th\u00f4ng m\u00e1u, v\u00e0 c\u00f3 th\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 t\u00ecnh tr\u1ea1ng thi\u1ebfu Kh\u00ed t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/qi-deficiency\">Thi\u1ebfu kh\u00ed<\/a>\u00a0v\u00e0 thi\u1ebfu m\u00e1u\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib215\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib215\"><span class=\"anchor-text\">[215]<\/span><\/a>.\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Astragaloside IV t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/astragaloside-iv\">Astragaloside IV<\/a>\u00a0l\u00e0 m\u1ed9t trong nh\u1eefng th\u00e0nh ph\u1ea7n ho\u1ea1t \u0111\u1ed9ng ch\u00ednh c\u1ee7a\u00a0<em>C\u01a1 s\u1ed1 x\u01b0\u01a1ng c\u1ef1a<\/em>\u00a0v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 monome t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/monomer\">monome<\/a>\u00a0th\u00e0nh ph\u1ea7n c\u1ee7a\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 x\u01b0\u01a1ng c\u1ef1a t\u1eeb c\u00e1c trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/astragalus\">x\u01b0\u01a1ng c\u1ef1a<\/a>\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 saponin t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/saponin\">saponin<\/a>. N\u00f3 th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng l\u00e0m ti\u00eau chu\u1ea9n \u0111\u1ec3 ki\u1ec3m tra ch\u1ea5t l\u01b0\u1ee3ng c\u1ee7a x\u01b0\u01a1ng c\u1ef1a\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib216\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib216\"><span class=\"anchor-text\">[216]<\/span><\/a>. Astragaloside IV c\u00f3 nhi\u1ec1u lo\u1ea1i\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c ho\u1ea1t \u0111\u1ed9ng sinh h\u1ecdc t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/biological-activity\">ho\u1ea1t \u0111\u1ed9ng sinh h\u1ecdc<\/a>v\u00e0 ph\u1ea1m vi nghi\u00ean c\u1ee9u li\u00ean quan \u0111\u1ebfn nhi\u1ec1u c\u01a1 quan v\u00e0 m\u00f4 nh\u01b0 n\u00e3o, gan, tim, ph\u1ed5i, th\u1eadn, d\u1ea1 d\u00e0y, ru\u1ed9t, m\u1ea1ch m\u00e1u, v.v.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib217\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib217\"><span class=\"anchor-text\">[217]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib218\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib218\"><span class=\"anchor-text\">[218]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib219\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib219\"><span class=\"anchor-text\">[219]<\/span><\/a>\u00a0N\u00f3 c\u00f3 c\u00e1c ho\u1ea1t \u0111\u1ed9ng sinh h\u1ecdc nh\u01b0 ch\u1ed1ng vi\u00eam, ch\u1ed1ng vi-r\u00fat, ch\u1ed1ng apoptosis, th\u00fac \u0111\u1ea9y\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 s\u1ef1 t\u0103ng sinh t\u1ebf b\u00e0o t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-proliferation\">t\u0103ng sinh t\u1ebf b\u00e0o<\/a>, \u0111i\u1ec1u ti\u1ebft\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 b\u1ec7nh th\u1ecf t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/rabbit-disease\">b\u1ec7nh th\u1ecf<\/a>, \u0111i\u1ec1u h\u00f2a l\u01b0\u1ee3ng \u0111\u01b0\u1eddng trong m\u00e1u, l\u00e0m ch\u1eadm l\u00e3o h\u00f3a v\u00e0 \u1ee9c ch\u1ebf ung th\u01b0\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib217\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib217\"><span class=\"anchor-text\">[217]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib218\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib218\"><span class=\"anchor-text\">[218]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib219\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib219\"><span class=\"anchor-text\">[219]<\/span><\/a>. Nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e2y c\u1ee7a ch\u00fang t\u00f4i \u0111\u00e3 x\u00e1c \u0111\u1ecbnh astragaloside IV l\u00e0 m\u1ed9t t\u00e1c nh\u00e2n b\u1ea3o v\u1ec7 th\u1ea7n kinh ti\u1ec1m n\u0103ng, \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong \u0111i\u1ec1u tr\u1ecb IS. V\u00ed d\u1ee5, n\u00f3 c\u00f3 th\u1ec3 b\u1ea3o v\u1ec7 h\u00e0ng r\u00e0o m\u00e1u n\u00e3o, c\u1ea3i thi\u1ec7n chuy\u1ec3n h\u00f3a n\u0103ng l\u01b0\u1ee3ng, \u1ee9c ch\u1ebf qu\u00e1 tr\u00ecnh ch\u1ebft t\u1ebf b\u00e0o th\u1ea7n kinh, \u1ee9c ch\u1ebf ph\u1ea3n \u1ee9ng vi\u00eam, stress oxy h\u00f3a v\u00e0 ph\u00e1t huy t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 th\u1ea7n kinh, t\u1eeb \u0111\u00f3 c\u1ea3i thi\u1ec7n t\u00ecnh tr\u1ea1ng thi\u1ebfu m\u00e1u n\u00e3o\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib220\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib220\"><span class=\"anchor-text\">[220]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib221\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib221\"><span class=\"anchor-text\">[221]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib222\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib222\"><span class=\"anchor-text\">[222]<\/span><\/a>. V\u1ec1 m\u1eb7t pyroptosis, Tang et al. ph\u00e1t hi\u1ec7n ra r\u1eb1ng d\u00f2ng si\u00eau nh\u1ecf NLRP3 \u0111\u00e3 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t trong qu\u00e1 tr\u00ecnh t\u00e1i t\u01b0\u1edbi m\u00e1u n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 \u1edf chu\u1ed9t v\u00e0 vi\u1ec7c \u1ee9c ch\u1ebf d\u00f2ng si\u00eau nh\u1ecf NLRP3 ho\u1eb7c \u1ee9c ch\u1ebf Caspase-1 \u1edf h\u1ea1 l\u01b0u c\u1ee7a n\u00f3 c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m b\u1edbt t\u00ecnh tr\u1ea1ng t\u00e1i t\u01b0\u1edbi m\u00e1u do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 n\u00e3o \u1edf chu\u1ed9t b\u1ecb t\u1ed5n th\u01b0\u01a1ng\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib223\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib223\"><span class=\"anchor-text\">[223]<\/span><\/a>. Astragaloside IV c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m \u0111i\u1ec3m thi\u1ebfu h\u1ee5t th\u1ea7n kinh, gi\u1ea3m th\u1ec3 t\u00edch nh\u1ed3i m\u00e1u n\u00e3o v\u00e0 gi\u1ea3m n\u1ed3ng \u0111\u1ed9 protein NLRP3, Caspase-1, pro-IL-1\u03b2, IL-1\u03b2, pro-IL-18 v\u00e0 IL-18 trong m\u00f4 n\u00e3o v\u00e0 \u1ee9c ch\u1ebf s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a protein NF-\u03baB b\u1ecb phosphoryl h\u00f3a. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y astragaloside IV c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng CIRI v\u00e0 c\u01a1 ch\u1ebf c\u1ee7a n\u00f3 c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c \u1ee9c ch\u1ebf NF-\u03baB\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 qu\u00e1 tr\u00ecnh phosphoryl h\u00f3a protein t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/protein-phosphorylation\">s\u1ef1 phosphoryl h\u00f3a protein<\/a>\u00a0v\u00e0 s\u1ef1 \u1ee9c ch\u1ebf k\u00edch ho\u1ea1t h\u1ed3ng c\u1ea7u NLRP3\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib223\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib223\"><span class=\"anchor-text\">[223]<\/span><\/a>. Li v\u00e0 c\u1ed9ng s\u1ef1. c\u0169ng ph\u00e1t hi\u1ec7n ra r\u1eb1ng astragaloside IV c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m t\u1ed5n th\u01b0\u01a1ng n\u00e3o do thi\u1ebfu oxy-thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 \u1edf chu\u1ed9t s\u01a1 sinh v\u00e0 \u1ee9c ch\u1ebf ph\u1ea3n \u1ee9ng vi\u00eam c\u1ee7a m\u00f4 n\u00e3o thi\u1ebfu oxy-thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 v\u00e0 t\u1ebf b\u00e0o th\u1ea7n kinh v\u00f9ng \u0111\u1ed3i th\u1ecb HT22 \u1edf chu\u1ed9t s\u01a1 sinh, c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c t\u00e1c \u0111\u1ed9ng b\u1eb1ng c\u00e1ch \u0111i\u1ec1u ch\u1ec9nh NLRP3 qua trung gian MMP-9\/ \u0110\u01b0\u1eddng d\u1eabn t\u00edn hi\u1ec7u Caspase-1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib224\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib224\"><span class=\"anchor-text\">[224]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0155\">\n<h4 id=\"sect0175\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.11. Saponin Panax notoginseng (PNS)<\/h4>\n<p id=\"p0210\"><em>Notoginseng C\u01a1 s\u1ed1 v\u00e0 Rhizoma<\/em>\u00a0l\u00e0 r\u1ec5 kh\u00f4 v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 th\u00e2n r\u1ec5 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/rhizome\">th\u00e2n r\u1ec5<\/a>\u00a0c\u1ee7a\u00a0<em><a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Panax t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/panax\">Panax<\/a><\/em><em>\u00a0notoginsen (Burk.)<\/em>\u00a0FH Chen, c\u00f3 ho\u1ea1t \u0111\u1ed9ng d\u01b0\u1ee3c l\u00fd trong h\u1ec7 th\u1ed1ng m\u00e1u, tim m\u1ea1ch, th\u1ea7n kinh v\u00e0 mi\u1ec5n d\u1ecbch\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib225\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib225\"><span class=\"anchor-text\">[225]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib226\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib226\"><span class=\"anchor-text\">[226]<\/span><\/a>. PNS l\u00e0 th\u00e0nh ph\u1ea7n ho\u1ea1t ch\u1ea5t ch\u00ednh c\u1ee7a n\u00f3, ch\u1ee9a nhi\u1ec1u lo\u1ea1i saponin \u0111\u01a1n ph\u00e2n, v\u00e0 c\u00e1c ch\u1ebf ph\u1ea9m c\u1ee7a n\u00f3 nh\u01b0 thu\u1ed1c ti\u00eam Xuesaitong \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong ph\u00f2ng ng\u1eeba v\u00e0 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh v\u1ec1 tim m\u1ea1ch v\u00e0 m\u1ea1ch m\u00e1u n\u00e3o.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib227\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib227\"><span class=\"anchor-text\">[227]<\/span><\/a>. C\u00e1c nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e2y v\u00e0 nghi\u00ean c\u1ee9u hi\u1ec7n t\u1ea1i c\u1ee7a ch\u00fang t\u00f4i \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng PNS c\u00f3 nhi\u1ec1u t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd kh\u00e1c nhau trong ch\u1ea5n th\u01b0\u01a1ng n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9, ch\u1eb3ng h\u1ea1n nh\u01b0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 thu\u1ed1c ch\u1ed1ng huy\u1ebft kh\u1ed1i t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antithrombotic\">ch\u1ed1ng huy\u1ebft kh\u1ed1i<\/a>, ch\u1ed1ng vi\u00eam, ch\u1ed1ng oxy h\u00f3a, \u1ee9c ch\u1ebf qu\u00e1 tr\u00ecnh apoptosis c\u1ee7a t\u1ebf b\u00e0o th\u1ea7n kinh n\u00e3o v\u00e0 c\u1ea3i thi\u1ec7n t\u1ed5n th\u01b0\u01a1ng h\u00e0ng r\u00e0o m\u00e1u n\u00e3o\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib228\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib228\"><span class=\"anchor-text\">[228]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib229\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib229\"><span class=\"anchor-text\">[229]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib230\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib230\"><span class=\"anchor-text\">[230]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib231\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib231\"><span class=\"anchor-text\">[231]<\/span><\/a>. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y PNS c\u00f3 th\u1ec3 \u0111\u00f3ng vai tr\u00f2 b\u1ea3o v\u1ec7 trong t\u00ecnh tr\u1ea1ng thi\u1ebfu m\u00e1u n\u00e3o th\u00f4ng qua nhi\u1ec1u m\u1ee5c ti\u00eau. C\u00e1c nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng PNS c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf s\u1ef1 k\u00edch ho\u1ea1t c\u1ee7a d\u00f2ng si\u00eau nh\u1ecf NLRP3 v\u00e0 th\u00fac \u0111\u1ea9y c\u00f3 ch\u1ecdn l\u1ecdc\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 qu\u00e1 tr\u00ecnh gi\u1ea3m thi\u1ec3u t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitophagy\">ch\u1ee9ng gi\u1ea3m ph\u00e2n<\/a>\u00a0trong qu\u00e1 tr\u00ecnh t\u00e1i t\u01b0\u1edbi m\u00e1u n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 \u1edf chu\u1ed9t. Vi\u1ec7c \u1ee9c ch\u1ebf ty th\u1ec3 c\u00f3 th\u1ec3 \u0111\u1ea3o ng\u01b0\u1ee3c t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf c\u1ee7a PNS \u0111\u1ed1i v\u1edbi h\u1ed3ng c\u1ea7u NLRP3, cho th\u1ea5y r\u1eb1ng ty th\u1ec3 l\u00e0m trung gian t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf c\u1ee7a PNS \u0111\u1ed1i v\u1edbi ho\u1ea1t h\u00f3a h\u1ed3ng c\u1ea7u NLRP3 trong t\u00e1i t\u01b0\u1edbi m\u00e1u n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9. Ngo\u00e0i ra, m\u1ee9c \u0111\u1ed9 protein PINK1 v\u00e0 Parkin trong ty th\u1ec3 t\u0103ng l\u00ean trong qu\u00e1 tr\u00ecnh t\u00e1i t\u01b0\u1edbi m\u00e1u n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 \u1edf chu\u1ed9t v\u00e0 PNS c\u00f3 th\u1ec3 l\u00e0m t\u0103ng th\u00eam m\u1ee9c \u0111\u1ed9 protein PINK1 v\u00e0 Parkin trong ty th\u1ec3 c\u1ee7a m\u00f4 n\u00e3o. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y PNS c\u00f3 th\u1ec3 th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh gi\u1ea3m ph\u00e2n trong t\u00e1i t\u01b0\u1edbi m\u00e1u n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 th\u00f4ng qua con \u0111\u01b0\u1eddng PINK1\/Parkin\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib232\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib232\"><span class=\"anchor-text\">[232]<\/span><\/a>. T\u00f3m l\u1ea1i, PNS th\u00fac \u0111\u1ea9y c\u00f3 ch\u1ecdn l\u1ecdc t\u00ecnh tr\u1ea1ng gi\u1ea3m thi\u1ec3u th\u00f4ng qua con \u0111\u01b0\u1eddng PINK1\/Parkin, \u1ee9c ch\u1ebf s\u1ef1 k\u00edch ho\u1ea1t c\u1ee7a d\u00f2ng si\u00eau nh\u1ecf NLRP3 trong t\u00e1i t\u01b0\u1edbi m\u00e1u n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 v\u00e0 l\u00e0m gi\u1ea3m t\u1ed5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 n\u00e3o.<\/p>\n<\/section>\n<\/section>\n<section id=\"sec0160\">\n<h3 id=\"sect0180\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">5.2. Chi\u1ebft xu\u1ea5t th\u1ef1c v\u1eadt t\u1ef1 nhi\u00ean<\/h3>\n<section id=\"sec0165\">\n<h4 id=\"sect0185\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.1. Thu\u1ed1c s\u1eafc Taohong Siwu (THSWD)<\/h4>\n<p id=\"p0215\">THSWD l\u00e0 m\u1ed9t trong nh\u1eefng \u0111\u01a1n thu\u1ed1c kinh \u0111i\u1ec3n \u0111\u1ec3 th\u00fac \u0111\u1ea9y tu\u1ea7n ho\u00e0n m\u00e1u v\u00e0 lo\u1ea1i b\u1ecf\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 t\u00ecnh tr\u1ea1ng \u1ee9 m\u00e1u t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/blood-stasis\">\u1ee9 \u0111\u1ecdng m\u00e1u<\/a>, lo\u1ea1i b\u1ecf \u1ee9 m\u00e1u v\u00e0 t\u00e1i t\u1ea1o m\u00e1u m\u1edbi \u0111\u01b0\u1ee3c t\u1ea1o ra b\u1edfi \u201cG\u01b0\u01a1ng v\u00e0ng y h\u1ecdc\u201d c\u1ee7a Wu Qian th\u1eddi nh\u00e0 Thanh. C\u00e1c nghi\u00ean c\u1ee9u d\u01b0\u1ee3c l\u00fd hi\u1ec7n nay \u0111\u00e3 x\u00e1c nh\u1eadn r\u1eb1ng c\u00e1c th\u00e0nh ph\u1ea7n ho\u1ea1t ch\u1ea5t ch\u00ednh c\u1ee7a THSWD bao g\u1ed3m\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 axit ferulic t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ferulic-acid\">axit ferulic<\/a>,\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e2y rum t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/safflower\">c\u00e2y rum<\/a>\u00a0m\u00e0u v\u00e0ng v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 polysacarit t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glycan\">polysaccharid<\/a>. Trong s\u1ed1 \u0111\u00f3, axit ferulic c\u00f3 t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd nh\u01b0 \u1ee9c ch\u1ebf k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u, ch\u1ed1ng huy\u1ebft kh\u1ed1i, ch\u1ed1ng vi\u00eam v\u00e0 ch\u1ed1ng oxy h\u00f3a. C\u00e2y rum m\u00e0u v\u00e0ng c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng thi\u1ebfu m\u00e1u n\u00e3o, ch\u1ed1ng thi\u1ebfu m\u00e1u c\u01a1 tim, ch\u1ed1ng huy\u1ebft kh\u1ed1i, ch\u1ed1ng oxy h\u00f3a, ch\u1ed1ng kh\u1ed1i u v\u00e0 c\u00e1c t\u00e1c d\u1ee5ng kh\u00e1c. Chu v\u00e0 c\u1ed9ng s\u1ef1. ph\u00e1t hi\u1ec7n ra r\u1eb1ng THSWD \u0111\u00e3 c\u1ea3i thi\u1ec7n ch\u1ee9c n\u0103ng suy gi\u1ea3m th\u1ea7n kinh, th\u1ec3 t\u00edch nh\u1ed3i m\u00e1u n\u00e3o v\u00e0 h\u00ecnh th\u00e1i m\u00f4 n\u00e3o sau ch\u1ea5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 n\u00e3o v\u00e0 gi\u1ea3m \u0111\u00e1ng k\u1ec3 n\u1ed3ng \u0111\u1ed9 protein DRP1, NLRP3, Caspase-1 v\u00e0 IL-1 \u03b2\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib233\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib233\"><span class=\"anchor-text\">[233]<\/span><\/a>. N\u00f3 ch\u1ec9 ra r\u1eb1ng t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb c\u1ee7a THSWD \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u1ed3i m\u00e1u n\u00e3o c\u00f3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c \u1ee9c ch\u1ebf con \u0111\u01b0\u1eddng DRP1\/NLRP3 li\u00ean quan \u0111\u1ebfn b\u1ec7nh pyroptosis. Nghi\u00ean c\u1ee9u s\u00e2u h\u01a1n cho th\u1ea5y h\u00e0m l\u01b0\u1ee3ng IL-1\u03b2 v\u00e0 IL-18 trong nh\u00f3m THSWD \u0111\u00e3 gi\u1ea3m \u0111\u00e1ng k\u1ec3 v\u00e0 m\u1ee9c \u0111\u1ed9 NLRP3, Caspase-1, Caspase-1 p10, ASC, TXNIP v\u00e0 GSDMD \u0111\u00e3 gi\u1ea3m. Vi\u1ec7c ph\u00e1t hi\u1ec7n c\u00e1c \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u cho th\u1ea5y THSWD l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 m\u1ee9c bi\u1ec3u hi\u1ec7n c\u1ee7a HMGB1\/RAGE, TLR4\/NF-\u03baB,\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 p38 MAPK t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/p38-mitogen-activated-protein-kinase\">p38 B\u1ea2N \u0110\u1ed2<\/a>\u00a0v\u00e0 JNK \u1edf v\u00f9ng n\u1eeda t\u1ed1i. T\u00f3m l\u1ea1i, THSWD l\u00e0m gi\u1ea3m m\u1ee9c \u0111\u1ed9 ph\u1ea3n \u1ee9ng vi\u00eam \u1edf chu\u1ed9t MCAO\/R, \u1ee9c ch\u1ebf s\u1ef1 k\u00edch ho\u1ea1t d\u00f2ng si\u00eau nh\u1ecf NLRP3 \u1edf chu\u1ed9t MCAO\/R v\u00e0 GSDMD \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3m. THSWD c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf ch\u1ee9ng pyroptosis, c\u00f3 th\u1ec3 b\u1ecb \u1ea3nh h\u01b0\u1edfng do \u1ee9c ch\u1ebf c\u00e1c \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u HMGB1\/TLR4\/NF-kB v\u00e0 MAPK\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib234\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib234\"><span class=\"anchor-text\">[234]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0170\">\n<h4 id=\"sect0190\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.2. Vi\u00ean nang Naoxinqing (NXQC)<\/h4>\n<p id=\"p0220\">Th\u00e0nh ph\u1ea7n ch\u00ednh c\u1ee7a NXQC l\u00e0 l\u00e1 c\u00e2y\u00a0<em><a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Diospyros kaki t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/persimmon\">Diospyros kaki<\/a><\/em>\u00a0Thunb (l\u00e1 h\u1ed3ng). C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng chi\u1ebft xu\u1ea5t l\u00e1 h\u1ed3ng c\u00f3 ch\u1ee9a flavonoid, axit h\u1eefu c\u01a1 v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 coumarin t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/coumarin\">coumarin<\/a>\u00a0v\u00e0 c\u00e1c h\u00f3a ch\u1ea5t kh\u00e1c c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng vi\u00eam, ch\u1ed1ng oxy h\u00f3a,\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 thu\u1ed1c h\u1ea1 huy\u1ebft \u00e1p t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antihypertensive-agent\">h\u1ea1 huy\u1ebft \u00e1p<\/a>, h\u1ea1 lipid m\u00e1u, c\u1ea3i thi\u1ec7n\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u01a1 tr\u01a1n m\u1ea1ch m\u00e1u t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascular-smooth-muscle\">c\u01a1 tr\u01a1n m\u1ea1ch m\u00e1u<\/a>\u00a0ch\u1ee9c n\u0103ng v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 huy\u1ebft \u0111\u1ed9ng t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hemodynamic\">huy\u1ebft \u0111\u1ed9ng<\/a>\u00a0ch\u1ee9c n\u0103ng. Thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh v\u1ec1 tim m\u1ea1ch v\u00e0 m\u1ea1ch m\u00e1u n\u00e3o\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib235\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib235\"><span class=\"anchor-text\">[235]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib236\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib236\"><span class=\"anchor-text\">[236]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib237\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib237\"><span class=\"anchor-text\">[237]<\/span><\/a>. C\u00e1c nghi\u00ean c\u1ee9u hi\u1ec7n t\u1ea1i \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng NXQC c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n hi\u1ec7u qu\u1ea3\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 ch\u1ee9ng x\u01a1 c\u1ee9ng \u0111\u1ed9ng m\u1ea1ch n\u00e3o t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebral-atherosclerosis\">x\u01a1 c\u1ee9ng \u0111\u1ed9ng m\u1ea1ch n\u00e3o<\/a>\u00a0v\u00e0 b\u1ea3o v\u1ec7 t\u1ed5n th\u01b0\u01a1ng th\u1ea7n kinh do thi\u1ebfu m\u00e1u n\u00e3o\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib238\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib238\"><span class=\"anchor-text\">[238]<\/span><\/a>. Min v\u00e0 c\u1ed9ng s\u1ef1. nh\u1eadn th\u1ea5y r\u1eb1ng NXQC c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n hi\u1ec7u qu\u1ea3 t\u00ecnh tr\u1ea1ng suy gi\u1ea3m kh\u1ea3 n\u0103ng h\u1ecdc t\u1eadp sau thi\u1ebfu m\u00e1u n\u00e3o v\u00e0 t\u0103ng c\u01b0\u1eddng ho\u1ea1t \u0111\u1ed9ng c\u1ee7a\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 superoxide dismutase t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/superoxide-dismutase\">superoxide dismutase<\/a>\u00a0V\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 lactate dehydrogenase t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/lactate-dehydrogenase\">lactate dehydrogenase<\/a>, t\u0103ng h\u00e0m l\u01b0\u1ee3ng GSH v\u00e0 gi\u1ea3m h\u00e0m l\u01b0\u1ee3ng\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 malondialdehyde t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/malonaldehyde\">malondialdehyde<\/a>. NXQC c\u0169ng c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3m c\u00e1c protein ASC, NLRP3 v\u00e0 Caspase-1 \u1edf v\u00f9ng h\u1ea3i m\u00e3 v\u00e0 gi\u1ea3m \u0111\u00e1ng k\u1ec3 h\u00e0m l\u01b0\u1ee3ng IL-18 v\u00e0 IL-1\u03b2. H\u1ecd c\u0169ng ph\u00e1t hi\u1ec7n ra r\u1eb1ng c\u00e1c t\u1ebf b\u00e0o d\u01b0\u01a1ng t\u00ednh v\u1edbi ph\u00e2n t\u1eed-1 k\u1ebft d\u00ednh t\u1ebf b\u00e0o n\u1ed9i m\u00f4 ti\u1ec3u c\u1ea7u \u1edf chu\u1ed9t nh\u1ea3y \u0111\u00e3 t\u0103ng l\u00ean \u0111\u00e1ng k\u1ec3 sau khi can thi\u1ec7p b\u1eb1ng NXQC, v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c m\u1ed1i n\u1ed1i gi\u1eefa c\u00e1c t\u1ebf b\u00e0o t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-junction\">m\u1ed1i n\u1ed1i gi\u1eefa c\u00e1c t\u1ebf b\u00e0o<\/a>\u00a0\u0111\u00e3 ch\u1eb7t ch\u1ebd. C\u00f3 \u00fd ki\u1ebfn cho r\u1eb1ng NXQC c\u00f3 th\u1ec3 b\u1ea3o v\u1ec7 hi\u1ec7u qu\u1ea3 h\u00ecnh th\u00e1i c\u1ee7a\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 v\u00f9ng CA1 h\u1ed3i h\u1ea3i m\u00e3 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/sommers-sector\">v\u00f9ng CA1 h\u1ed3i h\u1ea3i m\u00e3<\/a>\u00a0c\u1ee7a chu\u1ed9t nh\u1ea3y, b\u1ea3o v\u1ec7 ch\u1ee9c n\u0103ng m\u1ea1ch m\u00e1u n\u00e3o v\u00e0 sau \u0111\u00f3 \u1ee9c ch\u1ebf ch\u1ea5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 n\u00e3o\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib239\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib239\"><span class=\"anchor-text\">[239]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0175\">\n<h4 id=\"sect0195\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.3. Thu\u1ed1c s\u1eafc Buyang Huanwu (BYHWD) v\u00e0 c\u00e1c bi\u1ebfn th\u1ec3 c\u1ee7a n\u00f3<\/h4>\n<p id=\"p0225\">BYHWD l\u00e0 m\u1ed9t ng\u01b0\u1eddi n\u1ed5i ti\u1ebfng\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 y h\u1ecdc c\u1ed5 truy\u1ec1n Trung Qu\u1ed1c t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/traditional-chinese-medicine\">y h\u1ecdc c\u1ed5 truy\u1ec1n Trung Qu\u1ed1c<\/a>\u00a0c\u00f4ng th\u1ee9c d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb \u0111\u1ed9t qu\u1ef5. B\u00e0i thu\u1ed1c n\u00e0y l\u1ea7n \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c ghi l\u1ea1i trong cu\u1ed1n \u201cY h\u1ecdc kinh \u0111i\u1ec3n\u201d c\u1ee7a V\u01b0\u01a1ng Thanh Nh\u00e2n v\u00e0o th\u1eddi nh\u00e0 Thanh\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib240\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib240\"><span class=\"anchor-text\">[240]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib241\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib241\"><span class=\"anchor-text\">[241]<\/span><\/a>. N\u00f3 l\u00e0 m\u1ed9t \u0111\u1ea1i di\u1ec7n xu\u1ea5t s\u1eafc c\u1ee7a b\u00e0i thu\u1ed1c b\u1ed5 kh\u00ed v\u00e0 k\u00edch ho\u1ea1t m\u00e1u. N\u00f3 c\u00f3 ch\u1ee9c n\u0103ng b\u1ed5 kh\u00ed, th\u00fac \u0111\u1ea9y tu\u1ea7n ho\u00e0n m\u00e1u v\u00e0 n\u1ea1o v\u00e9t c\u00e1c t\u00e0i s\u1ea3n th\u1ebf ch\u1ea5p. C\u00e1c nghi\u00ean c\u1ee9u y h\u1ecdc d\u1ef1a tr\u00ean b\u1eb1ng ch\u1ee9ng c\u1ee7a n\u00f3 \u0111\u00e3 cho th\u1ea5y hi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng t\u1ed1t\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib242\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib242\"><span class=\"anchor-text\">[242]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib243\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib243\"><span class=\"anchor-text\">[243]<\/span><\/a>. Nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e2y c\u1ee7a ch\u00fang t\u00f4i cho th\u1ea5y BYHWD\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 glycoside t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glycoside\">glycoside<\/a>\u00a0c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng th\u1ea7n kinh, gi\u1ea3m t\u1ed5n th\u01b0\u01a1ng t\u1ebf b\u00e0o th\u1ea7n kinh v\u00e0 \u1ee9c ch\u1ebf b\u1ec7nh pyroptosis t\u1ebf b\u00e0o th\u1ea7n kinh. Glycoside BYHWD l\u00e0 c\u00e1c ho\u1ea1t ch\u1ea5t \u0111\u01b0\u1ee3c chi\u1ebft xu\u1ea5t t\u1eeb BYHWD, ch\u1ee7 y\u1ebfu bao g\u1ed3m astragaloside IV, paeoniflorin v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 amygdalin t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/amygdalin\">amygdalin<\/a>. N\u00f3 l\u00e0 th\u00e0nh ph\u1ea7n ho\u1ea1t ch\u1ea5t d\u01b0\u1ee3c l\u00fd ch\u00ednh gi\u00fap b\u1ed5 th\u1eadn v\u00e0 k\u00edch ho\u1ea1t m\u00e1u, \u0111\u1ed3ng th\u1eddi c\u00f3 th\u1ec3 \u0111i\u1ec1u tr\u1ecb ch\u1ea5n th\u01b0\u01a1ng d\u00e2y th\u1ea7n kinh do thi\u1ebfu m\u00e1u n\u00e3o c\u1ee5c b\u1ed9.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib244\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib244\"><span class=\"anchor-text\">[244]<\/span><\/a>. H\u01a1n n\u1eefa, ch\u00fang t\u00f4i quan s\u00e1t th\u1ea5y r\u1eb1ng glycosid BYHWD \u1ee9c ch\u1ebf \u0111\u00e1ng k\u1ec3 s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a c\u00e1c protein NLRP3, ASC, pro-caspase-1, caspase-1 v\u00e0 IL-1\u03b2 c\u1ee7a con \u0111\u01b0\u1eddng pyroptosis ch\u00ednh t\u1eafc qua trung gian NLRP3\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib209\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib209\"><span class=\"anchor-text\">[209]<\/span><\/a>. T\u00f3m l\u1ea1i, glycosid BYHWD ph\u00e1t huy t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 th\u1ea7n kinh b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf ch\u1ee9ng pyroptosis t\u1ebf b\u00e0o th\u1ea7n kinh sau CIRI, c\u00f3 li\u00ean quan ch\u1eb7t ch\u1ebd \u0111\u1ebfn s\u1ef1 \u0111i\u1ec1u ch\u1ec9nh con \u0111\u01b0\u1eddng pyroptotic c\u1ed5 \u0111i\u1ec3n c\u1ee7a NLRP3. Ngo\u00e0i ra, Long Chi\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Thu\u1ed1c s\u1eafc t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/decoction\">Thu\u1ed1c s\u1eafc<\/a>\u00a0l\u00e0 m\u1ed9t c\u00f4ng th\u1ee9c th\u1ef1c nghi\u1ec7m \u0111\u01b0\u1ee3c BYHWD h\u00ecnh th\u00e0nh v\u1edbi \u0111\u1ec9a v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Achyranthes t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/achyranthes\">Achyranthes<\/a>\u00a0t\u1ee9 xuy\u00ean. N\u00f3 \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb l\u00e2m s\u00e0ng c\u01a1n \u0111\u1ed9t qu\u1ef5 c\u1ea5p t\u00ednh trong nhi\u1ec1u n\u0103m v\u00e0 hi\u1ec7u qu\u1ea3 r\u1ea5t t\u1ed1t\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib245\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib245\"><span class=\"anchor-text\">[245]<\/span><\/a>. C\u00e1c nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng Thu\u1ed1c s\u1eafc Long Chi c\u00f3 t\u00e1c d\u1ee5ng r\u00f5 r\u1ec7t trong vi\u1ec7c c\u1ea3i thi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng th\u1ea7n kinh \u1edf chu\u1ed9t sau CIRI, duy tr\u00ec tr\u1ea1ng th\u00e1i c\u1ee7a c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh trong m\u00f4 n\u00e3o v\u00e0 gi\u1ea3m th\u1ec3 t\u00edch nh\u1ed3i m\u00e1u n\u00e3o. V\u1ec1 m\u1eb7t can thi\u1ec7p b\u1ec7nh pyroptosis t\u1ebf b\u00e0o, Thu\u1ed1c s\u1eafc Long Chi c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a chu\u1ed9t sau CIRI v\u00e0 b\u1ea3o v\u1ec7\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 t\u1ed5n th\u01b0\u01a1ng t\u1ebf b\u00e0o th\u1ea7n kinh t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nerve-cell-lesion\">t\u1ed5n th\u01b0\u01a1ng t\u1ebf b\u00e0o th\u1ea7n kinh<\/a>\u00a0sau ch\u1ea5n th\u01b0\u01a1ng b\u1eb1ng c\u00e1ch \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3m s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a protein Caspase-1 v\u00e0 IL-18\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib245\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib245\"><span class=\"anchor-text\">[245]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0180\">\n<h4 id=\"sect0200\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.4. \u0110\u01a1n thu\u1ed1c Yiqi Huoxue (YQHXP)<\/h4>\n<p id=\"p0230\">YQHXP bao g\u1ed3m\u00a0<em>Angelicae Sinensis C\u01a1 s\u1ed1, C\u01a1 s\u1ed1 Astragali,\u00a0<\/em><em><a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Chuanxiong Rhizoma t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ligusticum-chuanxiong-extract\">Th\u00e2n r\u1ec5 Chuanxiong<\/a><\/em><em>, B\u00f2 C\u1ea1p, Leonuri Herba, Acori Tatarinowii Rhizoma, Borneolum Syntheticum<\/em>v\u00e0 \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c k\u1ebft qu\u1ea3 l\u00e2m s\u00e0ng t\u1ed1t\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib246\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib246\"><span class=\"anchor-text\">[246]<\/span><\/a>. C\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng YQHXP \u0111\u00e3 c\u1ea3i thi\u1ec7n \u0111i\u1ec3m ch\u1ee9c n\u0103ng th\u1ea7n kinh v\u00e0 t\u1ef7 l\u1ec7 nh\u1ed3i m\u00e1u n\u00e3o \u1edf chu\u1ed9t, \u0111\u1ed3ng th\u1eddi l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 IL-1\u03b2, TNF-\u03b1 v\u00e0 IL-18 trong m\u00f4 n\u00e3o v\u00e0 bi\u1ec3u hi\u1ec7n t\u01b0\u01a1ng \u0111\u1ed1i c\u1ee7a\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 P2RX7 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/p2rx7\">P2RX7<\/a>, Caspase-1, Caspase-11 v\u00e0 GSDMD trong m\u00f4 n\u00e3o thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9. Sau khi can thi\u1ec7p YQHXP, t\u00ecnh tr\u1ea1ng vi\u00eam ti\u1ebft ra v\u00e0 ph\u00f9 n\u1ec1 c\u1ee7a m\u00f4 n\u00e3o \u0111\u00e3 gi\u1ea3m \u0111\u00e1ng k\u1ec3, h\u00ecnh th\u00e1i t\u1ebf b\u00e0o v\u00e0 s\u1ef1 tho\u00e1i h\u00f3a kh\u00f4ng b\u00e0o th\u1ea7n kinh \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n. T\u00f3m l\u1ea1i, YQHXP c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m t\u00ecnh tr\u1ea1ng vi\u00eam m\u00f4 n\u00e3o \u1edf chu\u1ed9t b\u1ecb \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 c\u1ea5p t\u00ednh b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf ch\u1ee9ng pyroptosis\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib247\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib247\"><span class=\"anchor-text\">[247]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0185\">\n<h4 id=\"sect0205\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.5. Thu\u1ed1c s\u1eafc Shen Nao Fu Yuan (SNFYD)<\/h4>\n<p id=\"p0235\">SNFYD l\u00e0 li\u1ec1u thu\u1ed1c hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 d\u1ef1a tr\u00ean l\u00fd thuy\u1ebft \u0111i\u1ec1u tr\u1ecb \u0111\u1ed3ng th\u1eddi th\u1eadn v\u00e0 n\u00e3o. Th\u00e0nh ph\u1ea7n c\u1ee7a n\u00f3 l\u00e0:\u00a0<em>C\u01a1 s\u1ed1 x\u01b0\u01a1ng c\u1ef1a<\/em>\u00a030 g<em>,\u00a0<\/em><em><a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Rehmanniae t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/rehmannia\">Rehmanniae<\/a><\/em><em>\u00a0C\u01a1 s\u1ed1 Praeparata<\/em>\u00a010 g<em>, qu\u1ea3 ng\u00f4<\/em>\u00a010 g<em>, Dioscoreae Th\u00e2n r\u1ec5<\/em>\u00a015 g<em>, Rhodiolae Crenulatae Radix Et Rhizoma<\/em>\u00a020 g<em>,\u00a0<\/em><em><a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Moutan Cortex t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/moutan-cortex\">V\u1ecf n\u00fai<\/a><\/em>\u00a010 g<em>, Angelicae Sinensis C\u01a1 s\u1ed1<\/em>\u00a010 g<em>, Paeoniae C\u01a1 s\u1ed1 Rubra<\/em>\u00a010 g<em>,\u00a0<\/em><em><a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Pheretima t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/pheretima\">pheretima<\/a><\/em>\u00a010 g\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib248\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib248\"><span class=\"anchor-text\">[248]<\/span><\/a>. N\u00f3 \u0111\u01b0\u1ee3c k\u1ebft h\u1ee3p v\u1edbi m\u1ed9t s\u1ed1 l\u01b0\u1ee3ng l\u1edbn c\u00e1c lo\u1ea1i thu\u1ed1c b\u1ed5 kh\u00ed, b\u1ed5 sung tinh ch\u1ea5t v\u00e0 ti\u1ebfp th\u00eam sinh l\u1ef1c cho th\u1eadn, \u0111\u01b0\u1ee3c k\u1ebft h\u1ee3p v\u1edbi vi\u1ec7c k\u00edch ho\u1ea1t m\u00e1u v\u00e0 n\u1ea1o v\u00e9t t\u00e0i s\u1ea3n \u0111\u1ea3m b\u1ea3o. C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng sau khi l\u1eadp m\u00f4 h\u00ecnh OGD, PC12 b\u1ecb h\u01b0 h\u1ecfng \u0111\u00e1ng k\u1ec3 v\u00e0 c\u00e1c cytokine kh\u00e1c nhau trong qu\u00e1 tr\u00ecnh pyroptosis \u0111\u00e3 t\u0103ng l\u00ean \u0111\u00e1ng k\u1ec3\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib249\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib249\"><span class=\"anchor-text\">[249]<\/span><\/a>. Sau khi huy\u1ebft thanh ch\u1ee9a SNFYD v\u00e0 INF39 can thi\u1ec7p v\u00e0o c\u00e1c t\u1ed5n th\u01b0\u01a1ng\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 t\u1ebf b\u00e0o PC12 t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pc12-cell-line\">T\u1ebf b\u00e0o PC12<\/a>, h\u00ecnh th\u00e1i v\u00e0 ho\u1ea1t \u0111\u1ed9ng c\u1ee7a c\u00e1c t\u1ebf b\u00e0o PC12 \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n v\u00e0 vi\u1ec7c k\u00edch ho\u1ea1t con \u0111\u01b0\u1eddng pyroptosis NLRP3\/Caspase-1 c\u0169ng b\u1ecb suy y\u1ebfu theo \u0111\u00f3. N\u00f3 ch\u1ec9 ra r\u1eb1ng s\u1ef1 \u1ee9c ch\u1ebf con \u0111\u01b0\u1eddng n\u00e0y c\u00f3 li\u00ean quan \u0111\u1ebfn s\u1ef1 c\u1ea3i thi\u1ec7n tr\u1ea1ng th\u00e1i t\u1ebf b\u00e0o v\u00e0 c\u1ea3 SNFYD v\u00e0 INF39 \u0111\u1ec1u c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf s\u1ef1 k\u00edch ho\u1ea1t con \u0111\u01b0\u1eddng n\u00e0y. C\u00f3 \u00fd ki\u1ebfn cho r\u1eb1ng SNFYD c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m qu\u00e1 tr\u00ecnh apoptosis g\u00e2y vi\u00eam c\u1ee7a c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf NLRP3\/Caspase-1 v\u00e0 con \u0111\u01b0\u1eddng pyroptosis xu\u00f4i d\u00f2ng, t\u1eeb \u0111\u00f3 b\u1ea3o v\u1ec7 m\u00f4 th\u1ea7n kinh v\u00e0 \u0111\u1ea1t \u0111\u01b0\u1ee3c m\u1ee5c \u0111\u00edch \u0111i\u1ec1u tr\u1ecb nh\u1ed3i m\u00e1u n\u00e3o\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib250\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib250\"><span class=\"anchor-text\">[250]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0190\">\n<h4 id=\"sect0210\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.6. C\u00e1c chi\u1ebft xu\u1ea5t kh\u00e1c<\/h4>\n<p id=\"p0240\">Ngo\u00e0i ra, c\u00e1c nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng c\u00e1c lo\u1ea1i thu\u1ed1c ch\u1ed1ng huy\u1ebft kh\u1ed1i nh\u01b0 heparin c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n t\u1ed5n th\u01b0\u01a1ng ph\u1ed5i b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf b\u1ec7nh pyroptosis. V\u00ed d\u1ee5, Yang v\u00e0 c\u1ed9ng s\u1ef1. ph\u00e1t hi\u1ec7n ra r\u1eb1ng heparin \u1ee9c ch\u1ebf qu\u00e1 tr\u00ecnh apoptosis c\u1ee7a t\u1ebf b\u00e0o n\u1ed9i m\u00f4 ph\u1ed5i b\u1eb1ng c\u00e1ch ng\u0103n ch\u1eb7n ho\u1ea1t h\u00f3a caspase-11 do hMGB1 LPS g\u00e2y ra, \u0111\u00e2y c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t c\u00e1ch ti\u1ec1m n\u0103ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb t\u1ed5n th\u01b0\u01a1ng ph\u1ed5i do nhi\u1ec5m tr\u00f9ng huy\u1ebft\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib251\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib251\"><span class=\"anchor-text\">[251]<\/span><\/a>. Prathapan v\u00e0 c\u1ed9ng s\u1ef1. ph\u00e1t hi\u1ec7n ra r\u1eb1ng n\u01b0\u1edbc d\u1eeba m\u1ec1m c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng oxy h\u00f3a v\u00e0 ch\u1ed1ng huy\u1ebft kh\u1ed1i trong\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 nh\u1ed3i m\u00e1u c\u01a1 tim th\u1ef1c nghi\u1ec7m t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/experimental-myocardial-infarction\">nh\u1ed3i m\u00e1u c\u01a1 tim th\u1ef1c nghi\u1ec7m<\/a>\u00a0ng\u01b0\u1eddi m\u1eabu\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib252\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib252\"><span class=\"anchor-text\">[252]<\/span><\/a>, trong khi n\u01b0\u1edbc d\u1eeba non c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 m\u1ed9t s\u1ed1 b\u1ec7nh l\u00fd li\u00ean quan \u0111\u1ebfn\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 b\u1ec7nh Alzheimer t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/alzheimer-disease\">B\u1ec7nh Alzheimer<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib253\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib253\"><span class=\"anchor-text\">[253]<\/span><\/a>. Ng\u01b0\u1eddi ta ch\u1ec9 ra r\u1eb1ng n\u01b0\u1edbc d\u1eeba c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf ti\u1ec1m t\u00e0ng b\u1ec7nh pyroptosis v\u00e0 vai tr\u00f2 c\u1ee7a n\u00f3 trong vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh b\u1ec7nh pyroptosis \u1edf IS c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u trong t\u01b0\u01a1ng lai.<\/p>\n<p id=\"p0245\"><span class=\"small-caps\">L<\/span>-arginine l\u00e0 m\u1ed9t h\u1ee3p ch\u1ea5t h\u1eefu c\u01a1 c\u00f3 trong\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 protamine t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/protamine\">protamin<\/a>\u00a0v\u1edbi s\u1ed1 l\u01b0\u1ee3ng l\u1edbn\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib254\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib254\"><span class=\"anchor-text\">[254]<\/span><\/a>. N\u00f3 l\u00e0 ti\u1ec1n ch\u1ea5t cho qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 oxit nitric t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nitric-oxide\">oxit nitric<\/a>\u00a0(NO), b\u1ea3o v\u1ec7 n\u1ed9i m\u00f4 nguy\u00ean v\u1eb9n c\u1ee7a m\u1ea1ch m\u00e1u, ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 thu\u1ed1c gi\u00e3n m\u1ea1ch t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vasodilator-agent\">thu\u1ed1c gi\u00e3n m\u1ea1ch<\/a>\u00a0v\u00e0 m\u1ed9t ph\u00e2n t\u1eed ch\u1ed1ng x\u01a1 v\u1eefa \u0111\u1ed9ng m\u1ea1ch n\u1ed9i sinh\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib254\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib254\"><span class=\"anchor-text\">[254]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib255\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib255\"><span class=\"anchor-text\">[255]<\/span><\/a>. Th\u00ed nghi\u1ec7m tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y\u00a0<span class=\"small-caps\">L<\/span>-arginine c\u00f3 th\u1ec3 ph\u1ee9c t\u1ea1p\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/anticoagulation\">thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u<\/a>, ch\u1ed1ng \u0111\u00f4ng m\u00e1u v\u00e0\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 qu\u00e1 tr\u00ecnh ti\u00eau s\u1ee3i huy\u1ebft t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/fibrinolysis\">ti\u00eau fibrin<\/a>\u00a0c\u00e1c hi\u1ec7u \u1ee9ng\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib255\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib255\"><span class=\"anchor-text\">[255]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib256\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib256\"><span class=\"anchor-text\">[256]<\/span><\/a>. \u1ede chu\u1ed9t t\u0103ng huy\u1ebft \u00e1p, Cylwik et al. t\u00ecm th\u1ea5y r\u1eb1ng\u00a0<span class=\"small-caps\">L<\/span>-arginine c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m huy\u1ebft \u00e1p \u1edf chu\u1ed9t v\u00e0 \u0111i\u1ec1u tr\u1ecb l\u00e2u d\u00e0i gi\u00fap r\u00fat ng\u1eafn th\u1eddi gian h\u00f2a tan c\u1ee5c m\u00e1u \u0111\u00f4ng v\u00e0 th\u1eddi gian ch\u1ea3y m\u00e1u, \u0111\u1ed3ng th\u1eddi \u1ee9c ch\u1ebf k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u do collagen g\u00e2y ra. Ng\u01b0\u1eddi ta \u0111\u1ec1 ngh\u1ecb r\u1eb1ng\u00a0<span class=\"small-caps\">L<\/span>-arginine c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng huy\u1ebft kh\u1ed1i \u1edf chu\u1ed9t b\u1ecb t\u0103ng huy\u1ebft \u00e1p\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/phlebothrombosis\">huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch<\/a>\u00a0m\u1ed9t c\u00e1ch ph\u1ee9c t\u1ea1p\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib256\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib256\"><span class=\"anchor-text\">[256]<\/span><\/a>. M\u1ed9t nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y cho th\u1ea5y\u00a0<span class=\"small-caps\">L<\/span>-arginine c\u00f3 th\u1ec3 l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf ti\u1ec1m t\u00e0ng b\u1ec7nh pyroptosis: Tanuseputero et al. cho r\u1eb1ng\u00a0<span class=\"small-caps\">L<\/span>-arginine c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf m\u1ed9t ph\u1ea7n d\u00f2ng si\u00eau nh\u1ecf NLRP3 \u0111\u1ec3 l\u00e0m gi\u1ea3m nhi\u1ec5m tr\u00f9ng huy\u1ebft do nhi\u1ec5m tr\u00f9ng huy\u1ebft\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 ch\u1ea5n th\u01b0\u01a1ng th\u1eadn c\u1ea5p t\u00ednh t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/acute-kidney-injury\">ch\u1ea5n th\u01b0\u01a1ng th\u1eadn c\u1ea5p t\u00ednh<\/a>\u00a0\u1edf chu\u1ed9t\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib257\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib257\"><span class=\"anchor-text\">[257]<\/span><\/a>. D\u1ef1a tr\u00ean t\u00e1c d\u1ee5ng gi\u00e3n m\u1ea1ch, ch\u1ed1ng huy\u1ebft kh\u1ed1i v\u00e0 \u1ee9c ch\u1ebf c\u00e1c ho\u1ea1t \u0111\u1ed9ng g\u00e2y s\u1ed1t NLRP3 c\u1ee7a\u00a0<span class=\"small-caps\">L<\/span>-arginine, ng\u01b0\u1eddi ta cho r\u1eb1ng\u00a0<span class=\"small-caps\">L<\/span>-arginine c\u00f3 th\u1ec3 c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m t\u0103ng l\u01b0u l\u01b0\u1ee3ng m\u00e1u \u1edf v\u00f9ng thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 v\u00e0 \u1ee9c ch\u1ebf ch\u1ee9ng pyroptosis \u1edf IS.<\/p>\n<div>\n<p id=\"p0250\">B\u1ea3n t\u00f3m t\u1eaft c\u00e1c s\u1ea3n ph\u1ea9m t\u1ef1 nhi\u00ean \u0111i\u1ec1u ch\u1ec9nh b\u1ec7nh pyroptosis \u0111\u01b0\u1ee3c tr\u00ecnh b\u00e0y trong\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#tbl0010\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"tbl0010\"><span class=\"anchor-text\">ban 2<\/span><\/a>.<\/p>\n<div id=\"tbl0010\" class=\"tables colsep-0 rowsep-0 frame-topbot\">\n<p id=\"sp0025\"><span class=\"label\">ban 2<\/span>. T\u00f3m t\u1eaft c\u00e1c h\u1ee3p ch\u1ea5t t\u1ef1 nhi\u00ean \u0111i\u1ec1u h\u00f2a pyroptosis.<\/p>\n<div class=\"groups\">\n<table>\n<thead>\n<tr class=\"rowsep-1\">\n<th scope=\"col\">S\u1ea3n ph\u1ea9m t\u1ef1 nhi\u00ean<\/th>\n<th scope=\"col\">Ng\u01b0\u1eddi m\u1eabu\/B\u1ec7nh t\u1eadt<\/th>\n<th scope=\"col\">Gi\u1ed1ng lo\u00e0i<\/th>\n<th scope=\"col\">C\u00e1c hi\u1ec7u \u1ee9ng<\/th>\n<th scope=\"col\">Th\u1ea9m quy\u1ec1n gi\u1ea3i quy\u1ebft<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<th scope=\"row\">Gastrodin<\/th>\n<td>T\u1eafc\/t\u00e1i t\u01b0\u1edbi m\u00e1u \u0111\u1ed9ng m\u1ea1ch n\u00e3o gi\u1eefa (MCAO\/R), thi\u1ebfu oxy-glucose\/t\u00e1i oxy h\u00f3a (OGD\/R)<\/td>\n<td>Rattus norvegicus v\u00e0 t\u1ebf b\u00e0o th\u1ea7n kinh v\u1ecf n\u00e3o v\u00e0nh t\u1eeb Rattus norvegicus<\/td>\n<td>\u1ee8c ch\u1ebf b\u1ec7nh pyroptosis b\u1eb1ng c\u00e1ch \u0111i\u1ec1u h\u00f2a gi\u1ea3m NLRP3, c\u00e1c y\u1ebfu t\u1ed1 g\u00e2y vi\u00eam (IL-1\u03b2, IL-18) v\u00e0 caspase-1 b\u1ecb c\u1eaft; \u0111i\u1ec1u ch\u1ec9nh tr\u1ee5c lncRNA NEAT1\/miR-22\u20133p v\u00e0 tr\u1ee5c lncRNA NEAT1\/miR-22\u20133p<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib204\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib204\"><span class=\"anchor-text\">[204]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Tanshinon IIA<\/th>\n<td>OGD\/R<\/td>\n<td>T\u1ebf b\u00e0o BV2 (microglia t\u1eeb Mus musculus)<\/td>\n<td>Gi\u1ea3m s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a IL-1\u03b2 v\u00e0 IL-18 trong con \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u vi\u00eam NLRP3<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib205\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib205\"><span class=\"anchor-text\">[205]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Leonurine<\/th>\n<td>MCAO<\/td>\n<td>Rattus norvegicus<\/td>\n<td>Gi\u1ea3m bi\u1ec3u hi\u1ec7n c\u1ee7a NLRP3<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib206\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib206\"><span class=\"anchor-text\">[206]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Paeoniflorin<\/th>\n<td>MCAO<\/td>\n<td>Rattus norvegicus<\/td>\n<td>\u1ee8c ch\u1ebf m\u1ee9c \u0111\u1ed9 NLRP3, Caspase-1 v\u00e0 IL-1\u03b2<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib209\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib209\"><span class=\"anchor-text\">[209]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Butylphtalit<\/th>\n<td>MCAO<\/td>\n<td>Rattus norvegicus<\/td>\n<td>\u0110i\u1ec1u ch\u1ec9nh \u0111\u01b0\u1eddng d\u1eabn t\u00edn hi\u1ec7u h\u1ed3ng c\u1ea7u NLRP3<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib210\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib210\"><span class=\"anchor-text\">[210]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Breviscapine<\/th>\n<td>MCAO\/R<\/td>\n<td>Rattus norvegicus<\/td>\n<td>\u1ee8c ch\u1ebf s\u1ef1 k\u00edch ho\u1ea1t c\u00e1c t\u1ebf b\u00e0o vi\u00eam NLRP3 \u1edf v\u00f9ng \u0111\u1ed3i th\u1ecb c\u1ee7a chu\u1ed9t CCI, \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3m s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a protein Caspase 1, IL-6 v\u00e0 IL-1\u03b2, \u1ee9c ch\u1ebf s\u1ef1 k\u00edch ho\u1ea1t protein Caspase-3<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib211\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib211\"><span class=\"anchor-text\">[211]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Resveratrol<\/th>\n<td>MCAO\/R<\/td>\n<td>Rattus norvegicus<\/td>\n<td>\u0110i\u1ec1u ch\u1ec9nh c\u00e1c d\u00f2ng si\u00eau nh\u1ecf microglia NLRP3, Caspase-1 v\u00e0 ZO-1<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib212\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib212\"><span class=\"anchor-text\">[212]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">axit salvianolic<\/th>\n<td>MCAO\/R v\u00e0 OGD\/R<\/td>\n<td>Rattus norvegicus v\u00e0 microglia t\u1eeb Rattus norvegicus<\/td>\n<td>\u1ee8c ch\u1ebf s\u1ef1 k\u00edch ho\u1ea1t c\u1ee7a c\u00e1c d\u00f2ng h\u1ed3ng c\u1ea7u NLRP3 v\u00e0 s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a c\u00e1c protein li\u00ean quan \u0111\u1ebfn d\u00f2ng h\u1ed3ng c\u1ea7u\/pyroxia NLRP3<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib213\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib213\"><span class=\"anchor-text\">[213]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Hispidulin<\/th>\n<td>MCAO<\/td>\n<td>Rattus norvegicus<\/td>\n<td>\u1ee8c ch\u1ebf ch\u1ee9ng pyroptosis qua trung gian NLRP3 b\u1eb1ng c\u00e1ch \u0111i\u1ec1u ch\u1ec9nh \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u AMPK\/GSK3\u03b2<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib214\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib214\"><span class=\"anchor-text\">[214]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Astragaloside IV<\/th>\n<td>MCAO\/R<\/td>\n<td>Rattus norvegicus<\/td>\n<td>\u1ee8c ch\u1ebf s\u1ef1 k\u00edch ho\u1ea1t c\u1ee7a d\u00f2ng si\u00eau nh\u1ecf NLRP3; l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 protein NLRP3, Caspase-1, pro-IL-1\u03b2, IL-1\u03b2, pro-IL-18 v\u00e0 IL-18 trong m\u00f4 n\u00e3o; \u1ee9c ch\u1ebf s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a protein NF-\u03baB b\u1ecb phosphoryl h\u00f3a<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib223\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib223\"><span class=\"anchor-text\">[223]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Saponin Panax notoginseng<\/th>\n<td>MCAO\/R<\/td>\n<td>Rattus norvegicus<\/td>\n<td>\u0110i\u1ec1u ch\u1ec9nh con \u0111\u01b0\u1eddng PINK1\/Parkin; \u1ee9c ch\u1ebf s\u1ef1 k\u00edch ho\u1ea1t c\u1ee7a d\u00f2ng si\u00eau nh\u1ecf NLRP3<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib232\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib232\"><span class=\"anchor-text\">[232]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Thu\u1ed1c s\u1eafc Taohong Siwu<\/th>\n<td>MCAO<\/td>\n<td>Rattus norvegicus<\/td>\n<td>Gi\u1ea3m m\u1ee9c protein DRP1, NLRP3, Caspase-1 v\u00e0 IL-1 \u03b2<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib233\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib233\"><span class=\"anchor-text\">[233]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Thu\u1ed1c s\u1eafc Taohong Siwu<\/th>\n<td>MCAO\/R<\/td>\n<td>Rattus norvegicus<\/td>\n<td>\u1ee8c ch\u1ebf \u0111\u01b0\u1eddng d\u1eabn t\u00edn hi\u1ec7u HMGB1\/TLR4\/NF-kB v\u00e0 MAPK<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib234\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib234\"><span class=\"anchor-text\">[234]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Vi\u00ean nang Naoxinqing<\/th>\n<td>MCAO\/R<\/td>\n<td>Meriones unguiculatus<\/td>\n<td>\u0110i\u1ec1u ch\u1ec9nh gi\u1ea3m c\u00e1c protein ASC, NLRP3 v\u00e0 Caspase-1; Gi\u1ea3m h\u00e0m l\u01b0\u1ee3ng IL-18 v\u00e0 IL-1\u03b2.<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib239\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib239\"><span class=\"anchor-text\">[239]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Thu\u1ed1c s\u1eafc Buyang Huanwu<\/th>\n<td>MCAO\/R<\/td>\n<td>Rattus norvegicus<\/td>\n<td>\u1ee8c ch\u1ebf s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a c\u00e1c protein NLRP3, ASC, pro-caspase-1, caspase-1 v\u00e0 IL-1\u03b2 c\u1ee7a con \u0111\u01b0\u1eddng pyroptosis ch\u00ednh t\u1eafc qua trung gian NLRP3<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib244\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib244\"><span class=\"anchor-text\">[244]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Thu\u1ed1c s\u1eafc long chi<\/th>\n<td>MCAO\/R<\/td>\n<td>Rattus norvegicus<\/td>\n<td>\u0110i\u1ec1u ch\u1ec9nh gi\u1ea3m s\u1ef1 bi\u1ec3u hi\u1ec7n c\u1ee7a protein Caspase-1 v\u00e0 IL-18<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib245\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib245\"><span class=\"anchor-text\">[245]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u0110\u01a1n thu\u1ed1c Yiqi Huoxue<\/th>\n<td>MCAO<\/td>\n<td>Rattus norvegicus<\/td>\n<td>Gi\u1ea3m m\u1ee9c IL-1\u03b2, TNF-\u03b1 v\u00e0 IL-18 c\u0169ng nh\u01b0 bi\u1ec3u hi\u1ec7n t\u01b0\u01a1ng \u0111\u1ed1i c\u1ee7a P2RX7, Caspase-1, Caspase-11 v\u00e0 GSDMD<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib247\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib247\"><span class=\"anchor-text\">[247]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Thu\u1ed1c s\u1eafc Shen Nao Fu Yuan<\/th>\n<td>OGD<\/td>\n<td>T\u1ebf b\u00e0o PC12 t\u1eeb Rattus norvegicus<\/td>\n<td>\u1ee8c ch\u1ebf NLRP3\/Caspase-1<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib250\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib250\"><span class=\"anchor-text\">[250]<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/section>\n<\/section>\n<section id=\"sec0195\">\n<h2 id=\"sect0215\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">6. Tri\u1ec3n v\u1ecdng<\/h2>\n<p id=\"p0255\">Nh\u00f3m nghi\u00ean c\u1ee9u c\u1ee7a ch\u00fang t\u00f4i t\u1eeb l\u00e2u \u0111\u00e3 nghi\u00ean c\u1ee9u ch\u1ebf \u0111\u1ed9 ch\u1ebft t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c l\u1eadp tr\u00ecnh c\u1ee7a nhi\u1ec1u nh\u00f3m t\u1ebf b\u00e0o kh\u00e1c nhau (ch\u1eb3ng h\u1ea1n nh\u01b0 t\u1ebf b\u00e0o th\u1ea7n kinh, t\u1ebf b\u00e0o vi m\u00f4 v\u00e0 t\u1ebf b\u00e0o h\u00ecnh sao) trong \u0111\u01a1n v\u1ecb th\u1ea7n kinh m\u1ea1ch m\u00e1u sau IS. K\u1ebft h\u1ee3p v\u1edbi c\u00e1c b\u00e1o c\u00e1o nghi\u00ean c\u1ee9u kh\u00e1c, ch\u00fang t\u00f4i ph\u00e1t hi\u1ec7n ra r\u1eb1ng c\u00e1c ch\u1ebf \u0111\u1ed9 ch\u1ebft t\u1ebf b\u00e0o kh\u00e1c nhau nh\u01b0 apoptosis, ferroptosis v\u00e0 autophagy x\u1ea3y ra sau IS, v\u00e0 h\u00ecnh th\u00e1i c\u1ee7a apoptosis v\u00e0 pyroptosis c\u00f3 nh\u1eefng \u0111i\u1ec3m t\u01b0\u01a1ng \u0111\u1ed3ng nh\u1ea5t \u0111\u1ecbnh.\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 Vi\u00eam th\u1ea7n kinh t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroinflammation\">Vi\u00eam th\u1ea7n kinh<\/a>\u00a0sau IS l\u00e0 qu\u00e1 tr\u00ecnh b\u1ec7nh l\u00fd quan tr\u1ecdng nh\u1ea5t d\u1eabn \u0111\u1ebfn ch\u1ea5n th\u01b0\u01a1ng n\u00e3o, trong \u0111\u00f3 b\u1ec7nh pyroptosis l\u00e0 m\u1ed9t ph\u1ea7n quan tr\u1ecdng c\u1ee7a vi\u00eam th\u1ea7n kinh. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y pyroptosis c\u00f3 t\u1ea7m quan tr\u1ecdng b\u1ea5t th\u01b0\u1eddng trong qu\u00e1 tr\u00ecnh ch\u1ebft t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c l\u1eadp tr\u00ecnh li\u00ean quan \u0111\u1ebfn vi\u00eam th\u1ea7n kinh sau thi\u1ebfu m\u00e1u n\u00e3o. C\u00e1c con \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u li\u00ean quan \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t b\u1edfi b\u1ec7nh pyroptosis c\u0169ng giao nhau v\u1edbi c\u00e1c con \u0111\u01b0\u1eddng ch\u1ebft t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c l\u1eadp tr\u00ecnh kh\u00e1c, cho th\u1ea5y r\u1eb1ng vi\u1ec7c ph\u00e1t tri\u1ec3n thu\u1ed1c nh\u1eafm v\u00e0o b\u1ec7nh pyroptosis l\u00e0 m\u1ed9t c\u00e1ch quan tr\u1ecdng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb IS.<\/p>\n<p id=\"p0260\">\u0110\u1ed1i v\u1edbi nghi\u00ean c\u1ee9u hi\u1ec7n t\u1ea1i, v\u1eabn c\u00f2n nh\u1eefng l\u0129nh v\u1ef1c c\u1ea7n c\u1ea3i thi\u1ec7n: (1) Do c\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 b\u00ecnh th\u01b0\u1eddng h\u00f3a v\u00e0 th\u1ed1ng nh\u1ea5t trong m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt c\u1ee7a nghi\u00ean c\u1ee9u hi\u1ec7n t\u1ea1i, k\u1ebft lu\u1eadn v\u1ec1 b\u1ec7nh pyroptosis \u1edf c\u00e1c t\u1ebf b\u00e0o kh\u00e1c nhau c\u1ee7a\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 h\u1ec7 th\u1ea7n kinh t\u1eeb c\u00e1c Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nervous-system\">h\u1ec7 th\u1ea7n kinh<\/a>\u00a0kh\u00f4ng nh\u1ea5t qu\u00e1n. Do \u0111\u00f3, trong nghi\u00ean c\u1ee9u trong t\u01b0\u01a1ng lai v\u1ec1 b\u1ec7nh pyroptosis \u0111\u00f2i h\u1ecfi m\u1ed9t m\u00f4 h\u00ecnh \u1ed5n \u0111\u1ecbnh th\u1ed1ng nh\u1ea5t v\u00e0 chu\u1ea9n h\u00f3a h\u01a1n tr\u00ean m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt b\u1ecb \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9, m\u00f4 h\u00ecnh n\u00e0y c\u0169ng c\u00f3 th\u1ec3 x\u00e1c \u0111\u1ecbnh t\u00e1c d\u1ee5ng th\u1ef1c s\u1ef1 c\u1ee7a thu\u1ed1c ch\u1ed1ng pyroptosis. (2) C\u00e1c nghi\u00ean c\u1ee9u trong t\u01b0\u01a1ng lai c\u00f3 th\u1ec3 x\u00e1c minh t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 n\u00e3o l\u00e2u d\u00e0i c\u1ee7a c\u00e1c h\u1ee3p ch\u1ea5t t\u1ef1 nhi\u00ean v\u00e0 c\u01a1 ch\u1ebf \u0111i\u1ec1u ch\u1ec9nh b\u1ec7nh pyroptosis \u1edf nhi\u1ec1u m\u00f4 h\u00ecnh \u0111\u1ed9t qu\u1ef5 \u1edf lo\u00e0i g\u1eb7m nh\u1ea5m v\u00e0 \u0111\u1ed9ng v\u1eadt c\u00f3 v\u00fa l\u1edbn. Trong th\u1eddi gian t\u1edbi c\u1ea7n quan t\u00e2m nhi\u1ec1u h\u01a1n \u0111\u1ebfn\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pharmacokinetics\">d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/a>,\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 d\u01b0\u1ee3c l\u1ef1c h\u1ecdc t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pharmacodynamics\">d\u01b0\u1ee3c l\u1ef1c h\u1ecdc<\/a>v\u00e0 \u0111\u1eb7c t\u00ednh \u0111\u1ed9c t\u00ednh c\u1ee7a c\u00e1c h\u1ee3p ch\u1ea5t t\u1ef1 nhi\u00ean hi\u1ec7n \u0111ang \u0111i\u1ec1u ch\u1ec9nh b\u1ec7nh pyroptosis. (3) Ngo\u00e0i ra, t\u00e1c d\u1ee5ng hi\u1ec7p \u0111\u1ed3ng c\u1ee7a s\u1ef1 k\u1ebft h\u1ee3p c\u00e1c h\u1ee3p ch\u1ea5t t\u1ef1 nhi\u00ean trong vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh b\u1ec7nh pyroptosis trong \u0111\u1ed9t qu\u1ef5 thi\u1ebfu m\u00e1u n\u00e3o v\u00e0 t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 th\u1ea7n kinh trong vi\u1ec7c \u1ee9c ch\u1ebf vi\u00eam th\u1ea7n kinh c\u1ea7n \u0111\u01b0\u1ee3c kh\u00e1m ph\u00e1 trong t\u01b0\u01a1ng lai. (4) N\u1ebfu m\u1ecdi k\u1ebft qu\u1ea3 \u0111\u1ec1u thu\u1eadn l\u1ee3i th\u00ec b\u01b0\u1edbc ti\u1ebfp theo l\u00e0 ti\u1ebfn h\u00e0nh\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/clinical-trial\">c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng<\/a>\u00a0ti\u1ec1m n\u0103ng\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c ch\u1ea5t phytochemical t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o ra c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/phytochemical\">ch\u1ea5t th\u1ef1c v\u1eadt<\/a>\u00a0\u0111\u1ec3 nghi\u00ean c\u1ee9u t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 th\u1ea7n kinh c\u1ee7a ch\u00fang \u0111\u1ed1i v\u1edbi b\u1ec7nh thi\u1ebfu m\u00e1u n\u00e3o c\u1ee5c b\u1ed9\/\u0111\u1ed9t qu\u1ef5 (V\u00ed d\u1ee5: nh\u00f3m hi\u1ec7n \u0111ang ti\u1ebfn h\u00e0nh th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng Naotai Fang trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh m\u1ea1ch m\u00e1u n\u00e3o nh\u1ecf: ChiCTR1900024524).<\/p>\n<\/section>\n<section id=\"sec0200\">\n<h2 id=\"sect0220\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">7. T\u00f3m t\u1eaft<\/h2>\n<p id=\"p0265\">Pyroptosis, nh\u01b0 m\u1ed9t c\u00e1i ch\u1ebft t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c l\u1eadp tr\u00ecnh g\u00e2y vi\u00eam, \u0111\u00f3ng m\u1ed9t vai tr\u00f2 quan tr\u1ecdng trong qu\u00e1 tr\u00ecnh b\u1ec7nh l\u00fd c\u1ee7a \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 b\u1eb1ng c\u00e1ch g\u00e2y ch\u1ebft t\u1ebf b\u00e0o v\u00e0 vi\u00eam th\u1ea7n kinh ch\u1ee7 y\u1ebfu th\u00f4ng qua con \u0111\u01b0\u1eddng pyroptotic c\u1ed5 \u0111i\u1ec3n qua trung gian Caspase-1. M\u1ed1i quan h\u1ec7 gi\u1eefa c\u00e1c con \u0111\u01b0\u1eddng pyroptotic kh\u00f4ng ch\u00ednh t\u1eafc v\u00e0 IS v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c l\u00e0m r\u00f5. C\u00e1c c\u01a1 ch\u1ebf kh\u00e1c c\u1ee7a ch\u1ee9ng pyroptosis c\u1ea7n \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u th\u00eam trong t\u01b0\u01a1ng lai. Hi\u1ec7n nay, c\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 x\u00e1c nh\u1eadn r\u1eb1ng\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 vi\u1ec7c nh\u1eafm m\u1ee5c ti\u00eau thu\u1ed1c t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/drug-delivery-system\">nh\u1eafm m\u1ee5c ti\u00eau ma t\u00fay<\/a>\u00a0c\u00e1c protein ch\u00ednh c\u1ee7a con \u0111\u01b0\u1eddng pyroptosis c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m ch\u1ea5n th\u01b0\u01a1ng n\u00e3o do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 \u1edf m\u1ed9t m\u1ee9c \u0111\u1ed9 nh\u1ea5t \u0111\u1ecbnh, nh\u01b0ng nghi\u00ean c\u1ee9u c\u1ee7a h\u1ecd ch\u1ee7 y\u1ebfu gi\u1edbi h\u1ea1n \u1edf c\u00e1c th\u00ed nghi\u1ec7m tr\u00ean t\u1ebf b\u00e0o v\u00e0 \u0111\u1ed9ng v\u1eadt v\u00e0 thi\u1ebfu\u00a0<a class=\"topic-link\" title=\"T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng t\u1eeb Trang ch\u1ee7 \u0111\u1ec1 do AI t\u1ea1o c\u1ee7a ScienceDirect\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/clinical-research\">nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng<\/a>\u00a0ch\u1ee9ng c\u1edb. Do \u0111\u00f3, nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng s\u00e2u h\u01a1n \u0111\u1ec3 kh\u00e1m ph\u00e1 c\u01a1 ch\u1ebf \u0111i\u1ec1u h\u00f2a b\u1ec7nh pyroptosis \u1edf IS d\u1ef1 ki\u1ebfn s\u1ebd cung c\u1ea5p c\u00e1c chi\u1ebfn l\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb m\u1edbi v\u00e0 c\u01a1 s\u1edf l\u00fd thuy\u1ebft \u0111\u1ec3 ph\u00f2ng ng\u1eeba v\u00e0 \u0111i\u1ec1u tr\u1ecb \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9. V\u1ec1 vi\u1ec7c \u0111i\u1ec1u h\u00f2a b\u1ec7nh pyroptosis b\u1eb1ng c\u00e1c h\u1ee3p ch\u1ea5t t\u1ef1 nhi\u00ean, qua t\u1ed5ng qu\u00e1t h\u00f3a c\u1ee7a ch\u00fang t\u00f4i, c\u00f3 th\u1ec3 th\u1ea5y r\u1eb1ng c\u00e1c h\u1ee3p ch\u1ea5t th\u1ef1c v\u1eadt t\u1ef1 nhi\u00ean c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh t\u00ecnh tr\u1ea1ng thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 n\u00e3o b\u1eb1ng c\u00e1ch \u0111i\u1ec1u ch\u1ec9nh b\u1ec7nh pyroptosis kh\u00f4ng ch\u1ec9 tr\u00ean m\u1ed9t th\u00e0nh ph\u1ea7n duy nh\u1ea5t. C\u00e1c h\u1ee3p ch\u1ea5t th\u1ef1c v\u1eadt t\u1ef1 nhi\u00ean \u0111a th\u00e0nh ph\u1ea7n c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c th\u1ea5y l\u00e0 c\u00f3 t\u00e1c d\u1ee5ng hi\u1ec7p \u0111\u1ed3ng ti\u1ec1m n\u0103ng trong vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh d\u00f2ng vi\u00eam do pyroptosis g\u00e2y ra. \u0110i\u1ec1u n\u00e0y truy\u1ec1n c\u1ea3m h\u1ee9ng cho ch\u00fang t\u00f4i nghi\u00ean c\u1ee9u t\u00e1c d\u1ee5ng \u0111i\u1ec1u ch\u1ec9nh c\u1ee7a c\u00e1c h\u1ee3p ch\u1ea5t t\u1ef1 nhi\u00ean kh\u00e1c nhau \u0111\u1ed1i v\u1edbi t\u00ecnh tr\u1ea1ng vi\u00eam th\u1ea7n kinh qua trung gian pyroptosis g\u00e2y ra b\u1edfi c\u00e1c con \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u kh\u00e1c nhau trong t\u01b0\u01a1ng lai.<\/p>\n<\/section>\n<section id=\"sec0205\">\n<h2 id=\"sect0225\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">Tuy\u00ean b\u1ed1 \u0111\u00f3ng g\u00f3p quy\u1ec1n t\u00e1c gi\u1ea3 CRediT<\/h2>\n<p id=\"p0270\"><strong>Khai L\u00e2m D\u01b0\u01a1ng:<\/strong>\u00a0Kh\u00e1i ni\u1ec7m h\u00f3a, Ph\u01b0\u01a1ng ph\u00e1p lu\u1eadn, Ph\u00e2n t\u00edch h\u00ecnh th\u1ee9c, \u0110i\u1ec1u tra, Vi\u1ebft \u2013 b\u1ea3n th\u1ea3o g\u1ed1c;\u00a0<strong>L\u01b0u \u0110\u00ecnh T\u0103ng:<\/strong>\u00a0Kh\u00e1i ni\u1ec7m h\u00f3a, Ph\u01b0\u01a1ng ph\u00e1p lu\u1eadn, Ph\u1ea7n m\u1ec1m, Ph\u00e2n t\u00edch ch\u00ednh th\u1ee9c, \u0110i\u1ec1u tra, Vi\u1ebft \u2013 b\u1ea3n th\u1ea3o g\u1ed1c;\u00a0<strong>T\u0103ng T\u1ea5n T\u00f4ng:<\/strong>\u00a0Ph\u01b0\u01a1ng ph\u00e1p lu\u1eadn, Ph\u00e2n t\u00edch ch\u00ednh th\u1ee9c, \u0110i\u1ec1u tra;\u00a0<strong>\u0110\u00ecnh \u0110\u00ecnh B\u1ea3o:<\/strong>\u00a0Ph\u01b0\u01a1ng ph\u00e1p lu\u1eadn, Ph\u00e2n t\u00edch ch\u00ednh th\u1ee9c, \u0110i\u1ec1u tra, Vi\u1ebft \u2013 b\u1ea3n th\u1ea3o g\u1ed1c;\u00a0<strong>Ti\u1ec3u Vi\u1ec5n:<\/strong>\u00a0Ph\u01b0\u01a1ng ph\u00e1p lu\u1eadn, Ph\u00e2n t\u00edch ch\u00ednh th\u1ee9c, \u0110i\u1ec1u tra;\u00a0<strong>V\u01b0\u01a1ng S\u01a1n S\u01a1n:<\/strong>\u00a0Ph\u01b0\u01a1ng ph\u00e1p lu\u1eadn, Ph\u00e2n t\u00edch ch\u00ednh th\u1ee9c, \u0110i\u1ec1u tra;\u00a0<strong>V\u01b0\u01a1ng T\u01b0\u01a1ng:<\/strong>\u00a0Ph\u01b0\u01a1ng ph\u00e1p lu\u1eadn, Ph\u00e2n t\u00edch ch\u00ednh th\u1ee9c, \u0110i\u1ec1u tra;\u00a0<strong>H\u1ea1o Xu:<\/strong>\u00a0Ph\u01b0\u01a1ng ph\u00e1p lu\u1eadn, Ph\u00e2n t\u00edch ch\u00ednh th\u1ee9c, \u0110i\u1ec1u tra;\u00a0<strong>Kim V\u0103n Ca:<\/strong>\u00a0Kh\u00e1i ni\u1ec7m h\u00f3a, Ph\u01b0\u01a1ng ph\u00e1p lu\u1eadn, Ph\u00e2n t\u00edch h\u00ecnh th\u1ee9c, \u0110i\u1ec1u tra, Vi\u1ebft \u2013 \u0111\u00e1nh gi\u00e1 v\u00e0 ch\u1ec9nh s\u1eeda.<\/p>\n<\/section>\n<\/div>\n<section id=\"coi0005\">\n<h2 id=\"sect0230\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">Xung \u0111\u1ed9t v\u1ec1 tuy\u00ean b\u1ed1 l\u00e3i su\u1ea5t<\/h2>\n<p id=\"p0275\">C\u00e1c t\u00e1c gi\u1ea3 tuy\u00ean b\u1ed1 r\u1eb1ng h\u1ecd kh\u00f4ng c\u00f3 l\u1ee3i \u00edch t\u00e0i ch\u00ednh ho\u1eb7c m\u1ed1i quan h\u1ec7 c\u00e1 nh\u00e2n c\u1ea1nh tranh n\u00e0o c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn c\u00f4ng vi\u1ec7c \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o trong b\u00e0i vi\u1ebft n\u00e0y.<\/p>\n<\/section>\n<section id=\"ack0005\">\n<h2 id=\"sect0235\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">S\u1ef1 nh\u00ecn nh\u1eadn<\/h2>\n<p id=\"p0280\">C\u00f4ng vi\u1ec7c n\u00e0y \u0111\u01b0\u1ee3c h\u1ed7 tr\u1ee3 b\u1edfi\u00a0<span id=\"gs1\">Qu\u1ef9 khoa h\u1ecdc t\u1ef1 nhi\u00ean qu\u1ed1c gia Trung Qu\u1ed1c<\/span>\u00a0(<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs1\"><span class=\"anchor-text\">81774174<\/span><\/a>), c\u00e1c\u00a0<span id=\"gs2\">D\u1ef1 \u00e1n nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n tr\u1ecdng \u0111i\u1ec3m qu\u1ed1c gia c\u1ee7a Trung Qu\u1ed1c<\/span>\u00a0(KH\u00d4NG.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs2\"><span class=\"anchor-text\">2018YFC1704904<\/span><\/a>),\u00a0<span id=\"gs3\">Qu\u1ef9 khoa h\u1ecdc t\u1ef1 nhi\u00ean qu\u1ed1c gia t\u1ec9nh H\u1ed3 Nam<\/span>, Trung Qu\u1ed1c (<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs3\"><span class=\"anchor-text\">2020JJ5424<\/span><\/a>\u00a0V\u00e0\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs3\"><span class=\"anchor-text\">2020JJ5442<\/span><\/a>),\u00a0<span id=\"gs4\">D\u1ef1 \u00e1n Qu\u1ef9 m\u1edf k\u1ef7 lu\u1eadt \u201c\u0110\u00f4i h\u1ea1ng nh\u1ea5t\u201d c\u1ee7a \u0110\u1ea1i h\u1ecdc Y h\u1ecdc Trung Hoa H\u1ed3 Nam v\u1ec1 Y h\u1ecdc c\u1ed5 truy\u1ec1n Trung Qu\u1ed1c v\u00e0 ph\u01b0\u01a1ng T\u00e2y t\u00edch h\u1ee3p<\/span>\u00a0(<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs4\"><span class=\"anchor-text\">2020ZXYJH08<\/span><\/a>\u00a0V\u00e0\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs4\"><span class=\"anchor-text\">2020ZXYJH09<\/span><\/a>),\u00a0<span id=\"gs5\">D\u1ef1 \u00e1n Qu\u1ef9 Thanh ni\u00ean S\u1edf Gi\u00e1o d\u1ee5c t\u1ec9nh H\u1ed3 Nam<\/span>\u00a0(<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs5\"><span class=\"anchor-text\">21B0386<\/span><\/a>).<\/p>\n<\/section>\n<\/div>\n<div class=\"text-content u-font-serif\">\n<section id=\"da0005\">\n<h2 id=\"sect0020\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">S\u1ef1 s\u1eb5n c\u00f3 c\u1ee7a d\u1eef li\u1ec7u v\u00e0 t\u00e0i li\u1ec7u<\/h2>\n<p id=\"p0020\">D\u1eef li\u1ec7u \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 h\u1ed7 tr\u1ee3 nh\u1eefng ph\u00e1t hi\u1ec7n c\u1ee7a nghi\u00ean c\u1ee9u n\u00e0y \u0111\u01b0\u1ee3c bao g\u1ed3m trong b\u00e0i vi\u1ebft.<\/p>\n<\/section>\n<\/div>\n<div class=\"Tail text-s\"><\/div>\n<section id=\"bibliog0005\" class=\"bibliography u-font-serif text-s\">\n<h2 class=\"section-title u-h4 u-margin-l-top u-margin-xs-bottom\">Ng\u01b0\u1eddi gi\u1edbi thi\u1ec7u<\/h2>\n<section id=\"bb0005\" class=\"bibliography-sec\">\n<ol id=\"reference-links-bb0005\" class=\"references\">\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib1\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib1\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[1]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">LE Evans, JL Taylor, CJ Smith, HAT Pritchard, AS Greenstein, SM Allan<\/div>\n<div id=\"ref-id-sbref1\" class=\"title text-m\">C\u00e1c b\u1ec7nh \u0111i k\u00e8m v\u1ec1 tim m\u1ea1ch, vi\u00eam v\u00e0 b\u1ec7nh m\u1ea1ch m\u00e1u n\u00e3o nh\u1ecf<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Cardiovasc Res., 117 (13) (2021), trang 2575-2588,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1093\/cvr\/cvab284\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1093\/cvr\/cvab284<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Xem PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">B\u00e0i vi\u1ebft n\u00e0y \u0111\u01b0\u1ee3c truy c\u1eadp mi\u1ec5n ph\u00ed.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85121137397&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref1\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Cardiovascular%20comorbidities%2C%20inflammation%2C%20and%20cerebral%20small%20vessel%20disease&amp;publication_year=2021&amp;author=L.E.%20Evans&amp;author=J.L.%20Taylor&amp;author=C.J.%20Smith&amp;author=H.A.T.%20Pritchard&amp;author=A.S.%20Greenstein&amp;author=S.M.%20Allan\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref1\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib2\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib2\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[2]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">P. Han, W. Zhang, L. Kang, Y. Ma, L. Fu, L. Jia, H. Yu, X. Chen, L. Hou, L. Wang, X. Yu, M. Kohzuki, Q. Qu\u00e1ch<\/div>\n<div id=\"ref-id-sbref2\" class=\"title text-m\">B\u1eb1ng ch\u1ee9ng l\u00e2m s\u00e0ng v\u1ec1 l\u1ee3i \u00edch t\u1eadp th\u1ec3 d\u1ee5c \u0111\u1ed1i v\u1edbi \u0111\u1ed9t qu\u1ef5<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Khuy\u1ebfn c\u00e1o. Exp. Med. Biol., 1000 (2017), trang 131-151,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1007\/978-981-10-4304-8_9\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1007\/978-981-10-4304-8_9<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85032976954&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref2\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Clinical%20Evidence%20of%20Exercise%20Benefits%20for%20Stroke&amp;publication_year=2017&amp;author=P.%20Han&amp;author=W.%20Zhang&amp;author=L.%20Kang&amp;author=Y.%20Ma&amp;author=L.%20Fu&amp;author=L.%20Jia&amp;author=H.%20Yu&amp;author=X.%20Chen&amp;author=L.%20Hou&amp;author=L.%20Wang&amp;author=X.%20Yu&amp;author=M.%20Kohzuki&amp;author=Q.%20Guo\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref2\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib3\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib3\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[3]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">VL Feigin, M. Brainin, B. Norrving, S. Martins, RL Sacco, W. Hacke, M. Fisher, J. Pandian, P. Lindsay<\/div>\n<div id=\"ref-id-sbref3\" class=\"title text-m\">T\u1ed5 ch\u1ee9c \u0110\u1ed9t qu\u1ef5 Th\u1ebf gi\u1edbi (WSO): T\u1edd th\u00f4ng tin v\u1ec1 \u0110\u1ed9t qu\u1ef5 To\u00e0n c\u1ea7u 2022<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Int. J. Stroke, 17 (1) (2022), trang 18-29,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1177\/17474930211065917\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1177\/17474930211065917<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Xem PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">B\u00e0i vi\u1ebft n\u00e0y \u0111\u01b0\u1ee3c truy c\u1eadp mi\u1ec5n ph\u00ed.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85122375323&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref3\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=World%20Stroke%20Organization%20%3A%20Global%20Stroke%20Fact%20Sheet%202022&amp;publication_year=2022&amp;author=V.L.%20Feigin&amp;author=M.%20Brainin&amp;author=B.%20Norrving&amp;author=S.%20Martins&amp;author=R.L.%20Sacco&amp;author=W.%20Hacke&amp;author=M.%20Fisher&amp;author=J.%20Pandian&amp;author=P.%20Lindsay\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref3\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib4\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib4\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[4]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">PB Sporns, HJ Fullerton, S. Lee, H. Kim, WD Lo, MT Mackay, M. Wildgruber<\/div>\n<div id=\"ref-id-sbref4\" class=\"title text-m\">\u0110\u1ed9t qu\u1ef5 th\u1eddi th\u01a1 \u1ea5u<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Nat. M\u1ee5c s\u01b0 Dis. Prim., 8 (1) (2022), tr. 12,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1038\/s41572-022-00337-x\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1038\/s41572-022-00337-x<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85125345650&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref4\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Childhood%20stroke&amp;publication_year=2022&amp;author=P.B.%20Sporns&amp;author=H.J.%20Fullerton&amp;author=S.%20Lee&amp;author=H.%20Kim&amp;author=W.D.%20Lo&amp;author=M.T.%20Mackay&amp;author=M.%20Wildgruber\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref4\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib5\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib5\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[5]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">MY Wu, GT Yiang, WT Liao, AP Tsai, YL Cheng, PW Cheng, CY Li, CJ Li<\/div>\n<div id=\"ref-id-sbref5\" class=\"title text-m\">C\u00e1c kh\u00e1i ni\u1ec7m c\u01a1 h\u1ecdc hi\u1ec7n nay v\u1ec1 thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 v\u00e0 t\u1ed5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u<\/div>\n<\/div>\n<div class=\"host u-font-sans\">T\u1ebf b\u00e0o PhysiolBiochem, 46 (4) (2018), trang 1650-1667,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1159\/000489241\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1159\/000489241<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Xem PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">B\u00e0i vi\u1ebft n\u00e0y \u0111\u01b0\u1ee3c truy c\u1eadp mi\u1ec5n ph\u00ed.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85046014150&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref5\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Current%20mechanistic%20concepts%20in%20ischemia%20and%20reperfusion%20injury&amp;publication_year=2018&amp;author=M.Y.%20Wu&amp;author=G.T.%20Yiang&amp;author=W.T.%20Liao&amp;author=A.P.%20Tsai&amp;author=Y.L.%20Cheng&amp;author=P.W.%20Cheng&amp;author=C.Y.%20Li&amp;author=C.J.%20Li\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref5\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib6\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib6\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[6]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">K. 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Debette, AM Tuladhar, FE de Leeuw<\/div>\n<div id=\"ref-id-sbref7\" class=\"title text-m\">D\u1ecbch t\u1ec5 h\u1ecdc, nguy\u00ean nh\u00e2n v\u00e0 qu\u1ea3n l\u00fd \u0111\u1ed9t qu\u1ef5 thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 \u1edf ng\u01b0\u1eddi tr\u1ebb tu\u1ed5i<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Lancet Neurol., 17 (9) (2018), trang 790-801,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/S1474-4422(18)30233-3\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/S1474-4422(18)30233-3<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1474442218302333\/pdfft?md5=477909fe66f856d9a85dc0241c093220&amp;pid=1-s2.0-S1474442218302333-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref7\"><span class=\"anchor-text\">Xem PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1474442218302333\" aria-describedby=\"ref-id-sbref7\"><span class=\"anchor-text\">Xem b\u00e0i vi\u1ebft<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85051392583&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref7\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Epidemiology%2C%20aetiology%2C%20and%20management%20of%20ischaemic%20stroke%20in%20young%20adults&amp;publication_year=2018&amp;author=M.S.%20Ekker&amp;author=E.M.%20Boot&amp;author=A.B.%20Singhal&amp;author=K.S.%20Tan&amp;author=S.%20Debette&amp;author=A.M.%20Tuladhar&amp;author=F.E.%20de%20Leeuw\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref7\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib8\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib8\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[8]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">S. Wu, B. Wu, M. Liu, Z. Chen, W. Wang, CS Anderson, P. Sandercock, Y. Wang, Y. Huang, L. Cui, C. Pu, J. Jia, T. Zhang , X. Liu, S. Zhang, P. Xie, D. Fan, X. Ji, KL Wong, L. 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Ngh\u1ecb quy\u1ebft, 41 (3) (2020), trang 220-230,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.24272\/j.issn.2095-8137.2020.042\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.24272\/j.issn.2095-8137.2020.042<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85084692954&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref9\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=The%20pathological%20role%20of%20ferroptosis%20in%20ischemiareperfusion-related%20injury&amp;publication_year=2020&amp;author=H.F.%20Yan&amp;author=Q.Z.%20Tuo&amp;author=Q.Z.%20Yin&amp;author=P.%20Lei\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref9\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib10\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib10\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[10]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">MY Wu, GT Yiang, WT Liao, AP Tsai, YL Cheng, PW Cheng, CY Li, CJ Li<\/div>\n<div id=\"ref-id-sbref10\" class=\"title text-m\">C\u00e1c kh\u00e1i ni\u1ec7m c\u01a1 h\u1ecdc hi\u1ec7n t\u1ea1i v\u1ec1 ch\u1ea5n th\u01b0\u01a1ng thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 v\u00e0 t\u00e1i t\u01b0\u1edbi m\u00e1u<\/div>\n<\/div>\n<div class=\"host u-font-sans\">T\u1ebf b\u00e0o PhysiolBiochem, 46 (4) (2018), trang 1650-1667,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1159\/000489241\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1159\/000489241<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Xem PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">B\u00e0i vi\u1ebft n\u00e0y \u0111\u01b0\u1ee3c truy c\u1eadp mi\u1ec5n ph\u00ed.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85046014150&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref10\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Current%20Mechanistic%20Concepts%20in%20Ischemia%20and%20Reperfusion%20Injury&amp;publication_year=2018&amp;author=M.Y.%20Wu&amp;author=G.T.%20Yiang&amp;author=W.T.%20Liao&amp;author=A.P.%20Tsai&amp;author=Y.L.%20Cheng&amp;author=P.W.%20Cheng&amp;author=C.Y.%20Li&amp;author=C.J.%20Li\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref10\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib11\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib11\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[11]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">X. Li, N. Ma, J. Xu, Y. Zhang, P. Yang, X. Su, Y. Xing, N. An, F. Yang, G. Zhang, L. Zhang, Y. Xing<\/div>\n<div id=\"ref-id-sbref11\" class=\"title text-m\">Nh\u1eafm m\u1ee5c ti\u00eau b\u1ec7nh Ferroptosis: C\u01a1 ch\u1ebf b\u1ec7nh l\u00fd v\u00e0 \u0111i\u1ec1u tr\u1ecb ch\u1ea5n th\u01b0\u01a1ng do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9-t\u00e1i t\u01b0\u1edbi m\u00e1u<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Oxit. Med Cell Longev., 2021 (2021), \u0110i\u1ec1u 1587922,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1155\/2021\/1587922\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1155\/2021\/1587922<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85118990959&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref11\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Targeting%20Ferroptosis%3A%20Pathological%20Mechanism%20and%20Treatment%20of%20Ischemia-Reperfusion%20Injury&amp;publication_year=2021&amp;author=X.%20Li&amp;author=N.%20Ma&amp;author=J.%20Xu&amp;author=Y.%20Zhang&amp;author=P.%20Yang&amp;author=X.%20Su&amp;author=Y.%20Xing&amp;author=N.%20An&amp;author=F.%20Yang&amp;author=G.%20Zhang&amp;author=L.%20Zhang&amp;author=Y.%20Xing\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref11\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib12\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib12\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[12]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">M. Mahjoubin-Tehran, S. Rezaei, A. Jesmani, N. Birang, K. Morshedi, H. Khanbabaei, H. Khan, A. Piranviseh, M. Nejati, M. Aschner, H. Mirzaei<\/div>\n<div id=\"ref-id-sbref12\" class=\"title text-m\">T\u00e1c nh\u00e2n bi\u1ec3u sinh m\u1edbi trong sinh b\u1ec7nh h\u1ecdc \u0111\u1ed9t qu\u1ef5: T\u1eeb RNA kh\u00f4ng m\u00e3 h\u00f3a \u0111\u1ebfn RNA kh\u00f4ng m\u00e3 h\u00f3a ngo\u1ea1i b\u00e0o<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Sinh h\u1ecdc. Pharm., 140 (2021), \u0110i\u1ec1u 111753,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.biopha.2021.111753\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.biopha.2021.111753<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332221005357\/pdfft?md5=13a6710773ddbd431c3757f9058711d2&amp;pid=1-s2.0-S0753332221005357-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref12\"><span class=\"anchor-text\">Xem PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332221005357\" aria-describedby=\"ref-id-sbref12\"><span class=\"anchor-text\">Xem b\u00e0i vi\u1ebft<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85108373807&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref12\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=New%20epigenetic%20players%20in%20stroke%20pathogenesis%3A%20From%20non-coding%20RNAs%20to%20exosomal%20non-coding%20RNAs&amp;publication_year=2021&amp;author=M.%20Mahjoubin-Tehran&amp;author=S.%20Rezaei&amp;author=A.%20Jesmani&amp;author=N.%20Birang&amp;author=K.%20Morshedi&amp;author=H.%20Khanbabaei&amp;author=H.%20Khan&amp;author=A.%20Piranviseh&amp;author=M.%20Nejati&amp;author=M.%20Aschner&amp;author=H.%20Mirzaei\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref12\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib13\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib13\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[13]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">K. Yang, L. Zeng, A. Ge, S. Wang, J. Zeng, X. Yuan, Z. Mei, G. Wang, J. Ge<\/div>\n<div id=\"ref-id-sbref13\" class=\"title text-m\">M\u1ed9t t\u1ed5ng quan c\u00f3 h\u1ec7 th\u1ed1ng v\u1ec1 ti\u1ebfn tr\u00ecnh nghi\u00ean c\u1ee9u v\u1ec1 t\u00ecnh tr\u1ea1ng vi\u00eam th\u1ea7n kinh RNAin kh\u00f4ng m\u00e3 h\u00f3a v\u00e0 \u0111i\u1ec1u h\u00f2a mi\u1ec5n d\u1ecbch trong nh\u1ed3i m\u00e1u n\u00e3o\/t\u1ed5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9<\/div>\n<\/div>\n<div class=\"host u-font-sans\">\u0110\u1eb1ng tr\u01b0\u1edbc. Immunol., 13 (2022), \u0110i\u1ec1u 930171,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.3389\/fimmu.2022.930171\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.3389\/fimmu.2022.930171<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85140346409&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref13\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=A%20systematic%20review%20of%20theresearch%20progress%20of%20non-coding%20RNAin%20neuroinflammation%20and%20immuneregulation%20in%20cerebral%20infarctionischemia-reperfusion%20injury&amp;publication_year=2022&amp;author=K.%20Yang&amp;author=L.%20Zeng&amp;author=A.%20Ge&amp;author=S.%20Wang&amp;author=J.%20Zeng&amp;author=X.%20Yuan&amp;author=Z.%20Mei&amp;author=G.%20Wang&amp;author=J.%20Ge\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref13\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib14\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib14\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[14]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">K. Yang, L. Zeng, X. Yuan, S. Wang, A. Ge, H. Xu, J. Zeng, J. Ge<\/div>\n<div id=\"ref-id-sbref14\" class=\"title text-m\">C\u01a1 ch\u1ebf ferroptosis \u0111i\u1ec1u ch\u1ec9nh stress oxy h\u00f3a trong \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 v\u00e0 c\u01a1 ch\u1ebf \u0111i\u1ec1u h\u00f2a c\u00e1c th\u00e0nh ph\u1ea7n ho\u1ea1t t\u00ednh d\u01b0\u1ee3c l\u00fd t\u1ef1 nhi\u00ean<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Sinh h\u1ecdc. Pharm., 154 (2022), \u0110i\u1ec1u 113611,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.biopha.2022.113611\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.biopha.2022.113611<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222010009\/pdfft?md5=c10c64d3830cfc66d624f7112443f8c0&amp;pid=1-s2.0-S0753332222010009-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref14\"><span class=\"anchor-text\">Xem PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222010009\" aria-describedby=\"ref-id-sbref14\"><span class=\"anchor-text\">Xem b\u00e0i vi\u1ebft<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85137285700&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref14\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=The%20mechanism%20of%20ferroptosis%20regulating%20oxidative%20stress%20in%20ischemic%20stroke%20and%20the%20regulation%20mechanism%20of%20natural%20pharmacological%20active%20components&amp;publication_year=2022&amp;author=K.%20Yang&amp;author=L.%20Zeng&amp;author=X.%20Yuan&amp;author=S.%20Wang&amp;author=A.%20Ge&amp;author=H.%20Xu&amp;author=J.%20Zeng&amp;author=J.%20Ge\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref14\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib15\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib15\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[15]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">PJ Kelly, R. Lemmens, G. Tsivgoulis<\/div>\n<div id=\"ref-id-sbref15\" class=\"title text-m\">Nguy c\u01a1 vi\u00eam v\u00e0 \u0111\u1ed9t qu\u1ef5: m\u1ee5c ti\u00eau m\u1edbi \u0111\u1ec3 ph\u00f2ng ng\u1eeba<\/div>\n<\/div>\n<div class=\"host u-font-sans\">\u0110\u1ed9t qu\u1ef5, 52 (8) (2021), trang 2697-2706,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1161\/STROKEAHA.121.034388\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1161\/Strokeaha.121.034388<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span><\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85111435034&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref15\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Inflammation%20and%20stroke%20risk%3A%20a%20new%20target%20for%20prevention&amp;publication_year=2021&amp;author=P.J.%20Kelly&amp;author=R.%20Lemmens&amp;author=G.%20Tsivgoulis\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref15\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib16\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib16\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[16]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">D. Levard, I. Buendia, A. Lanquetin, M. Glavan, D. Vivien, M. Rubio<\/div>\n<div id=\"ref-id-sbref16\" class=\"title text-m\">L\u1ea5p \u0111\u1ea7y nh\u1eefng kho\u1ea3ng tr\u1ed1ng trong nghi\u00ean c\u1ee9u \u0111\u1ed9t qu\u1ef5: T\u1eadp trung v\u00e0o t\u00ecnh tr\u1ea1ng vi\u00eam v\u00e0 mi\u1ec5n d\u1ecbch<\/div>\n<\/div>\n<div class=\"host u-font-sans\">H\u00e0nh vi n\u00e3o. Mi\u1ec5n d\u1ecbch., 91 (2021), trang 649-667,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.bbi.2020.09.025\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.bbi.2020.09.025<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0889159120314835\/pdfft?md5=7f20c8efadebc4ba2e72b6ff156a4240&amp;pid=1-s2.0-S0889159120314835-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref16\"><span class=\"anchor-text\">Xem PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0889159120314835\" aria-describedby=\"ref-id-sbref16\"><span class=\"anchor-text\">Xem b\u00e0i vi\u1ebft<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85092252055&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref16\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Filling%20the%20gaps%20on%20stroke%20research%3A%20Focus%20on%20inflammation%20and%20immunity&amp;publication_year=2021&amp;author=D.%20Levard&amp;author=I.%20Buendia&amp;author=A.%20Lanquetin&amp;author=M.%20Glavan&amp;author=D.%20Vivien&amp;author=M.%20Rubio\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref16\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib17\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib17\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[17]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">J. Shi, W. Gao, F. Shao<\/div>\n<div id=\"ref-id-sbref17\" class=\"title text-m\">Pyroptosis: C\u00e1i ch\u1ebft t\u1ebf b\u00e0o ho\u1ea1i t\u1eed \u0111\u01b0\u1ee3c l\u1eadp tr\u00ecnh qua trung gian Gasdermin<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Xu h\u01b0\u1edbng Khoa h\u1ecdc H\u00f3a sinh, 42 (4) (2017), trang 245-254,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.tibs.2016.10.004\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.tibs.2016.10.004<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0968000416301827\/pdfft?md5=78b194c8f2c41e414a54a46eab39f285&amp;pid=1-s2.0-S0968000416301827-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref17\"><span class=\"anchor-text\">Xem PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0968000416301827\" aria-describedby=\"ref-id-sbref17\"><span class=\"anchor-text\">Xem b\u00e0i vi\u1ebft<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85007439966&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref17\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Pyroptosis%3A%20Gasdermin-Mediated%20Programmed%20Necrotic%20Cell%20Death&amp;publication_year=2017&amp;author=J.%20Shi&amp;author=W.%20Gao&amp;author=F.%20Shao\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref17\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib18\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib18\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[18]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">Y. Fang, S. Tian, Y. Pan, W. Li, Q. Wang, Y. Tang, T. Yu, X. Wu, Y. Shi, P. Ma, Y. Shu<\/div>\n<div id=\"ref-id-sbref18\" class=\"title text-m\">Pyroptosis: M\u1ed9t bi\u00ean gi\u1edbi m\u1edbi trong b\u1ec7nh ung th\u01b0<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Sinh h\u1ecdc. Pharm., 121 (2020), \u0110i\u1ec1u 109595,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.biopha.2019.109595\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.biopha.2019.109595<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332219352175\/pdfft?md5=7b9dcf8c8439cdfb441f17e4a6c467fb&amp;pid=1-s2.0-S0753332219352175-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref18\"><span class=\"anchor-text\">Xem PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332219352175\" aria-describedby=\"ref-id-sbref18\"><span class=\"anchor-text\">Xem b\u00e0i vi\u1ebft<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85074467088&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref18\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Pyroptosis%3A%20A%20new%20frontier%20in%20cancer&amp;publication_year=2020&amp;author=Y.%20Fang&amp;author=S.%20Tian&amp;author=Y.%20Pan&amp;author=W.%20Li&amp;author=Q.%20Wang&amp;author=Y.%20Tang&amp;author=T.%20Yu&amp;author=X.%20Wu&amp;author=Y.%20Shi&amp;author=P.%20Ma&amp;author=Y.%20Shu\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref18\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib19\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib19\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[19]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">YS Feng, ZX Tan, LY Wu, F. Dong, F. Zhang<\/div>\n<div id=\"ref-id-sbref19\" class=\"title text-m\">S\u1ef1 tham gia c\u1ee7a d\u00f2ng si\u00eau nh\u1ecf NLRP3 trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh tho\u00e1i h\u00f3a th\u1ea7n kinh<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Sinh h\u1ecdc. Pharm., 138 (2021), \u0110i\u1ec1u 111428,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.biopha.2021.111428\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.biopha.2021.111428<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332221002134\/pdfft?md5=71fc42926442dd2691967ef65289e469&amp;pid=1-s2.0-S0753332221002134-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref19\"><span class=\"anchor-text\">Xem PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332221002134\" aria-describedby=\"ref-id-sbref19\"><span class=\"anchor-text\">Xem b\u00e0i vi\u1ebft<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85101767999&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref19\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=The%20involvement%20of%20NLRP3%20inflammasome%20in%20the%20treatment%20of%20neurodegenerative%20diseases&amp;publication_year=2021&amp;author=Y.S.%20Feng&amp;author=Z.X.%20Tan&amp;author=L.Y.%20Wu&amp;author=F.%20Dong&amp;author=F.%20Zhang\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref19\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib20\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib20\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[20]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">J. Chen, Z. Wei, K. Fu, Y. Duan, M. Zhang, K. Li, T. Guo, R. Yin<\/div>\n<div id=\"ref-id-sbref20\" class=\"title text-m\">S\u1ef1 ch\u1ebft t\u1ebf b\u00e0o kh\u00f4ng apoptotic trong ung th\u01b0 bu\u1ed3ng tr\u1ee9ng: \u0110i\u1ec1u tr\u1ecb, kh\u00e1ng thu\u1ed1c v\u00e0 ti\u00ean l\u01b0\u1ee3ng<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Sinh h\u1ecdc. Pharm., 150 (2022), \u0110i\u1ec1u 112929,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.biopha.2022.112929\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.biopha.2022.112929<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222003183\/pdfft?md5=056cbffef01439e4b2fd4ed8e4300fd4&amp;pid=1-s2.0-S0753332222003183-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref20\"><span class=\"anchor-text\">Xem PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222003183\" aria-describedby=\"ref-id-sbref20\"><span class=\"anchor-text\">Xem b\u00e0i vi\u1ebft<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85129378630&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref20\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Non-apoptotic%20cell%20death%20in%20ovarian%20cancer%3A%20Treatment%2C%20resistance%20and%20prognosis&amp;publication_year=2022&amp;author=J.%20Chen&amp;author=Z.%20Wei&amp;author=K.%20Fu&amp;author=Y.%20Duan&amp;author=M.%20Zhang&amp;author=K.%20Li&amp;author=T.%20Guo&amp;author=R.%20Yin\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref20\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib21\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib21\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[21]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">K. Du, M. He, D. Zhao, Y. Wang, C. Ma, H. Liang, W. Wang, D. Min, L. Xue, F. Guo<\/div>\n<div id=\"ref-id-sbref21\" class=\"title text-m\">C\u01a1 ch\u1ebf c\u1ee7a con \u0111\u01b0\u1eddng ch\u1ebft t\u1ebf b\u00e0o trong tr\u1ea1ng th\u00e1i \u0111\u1ed9ng kinh v\u00e0 c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb li\u00ean quan<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Sinh h\u1ecdc. 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Chu, DW Abbott, TS Xiao<\/div>\n<div id=\"ref-id-sbref61\" class=\"title text-m\">Caspase-1 t\u01b0\u01a1ng t\u00e1c v\u1edbi Gasdermin D c\u00f3 chi\u1ec1u d\u00e0i \u0111\u1ea7y \u0111\u1ee7 th\u00f4ng qua hai giao di\u1ec7n ri\u00eang bi\u1ec7t gi\u00fap trung gian tuy\u1ec3n d\u1ee5ng Caspase v\u00e0 ph\u00e2n t\u00e1ch c\u01a1 ch\u1ea5t<\/div>\n<\/div>\n<div class=\"comment\">e5<\/div>\n<div class=\"host u-font-sans\">Mi\u1ec5n d\u1ecbch, 53 (1) (2020), trang 106-114,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.immuni.2020.06.007\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.immuni.2020.06.007<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Xem PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">B\u00e0i vi\u1ebft n\u00e0y \u0111\u01b0\u1ee3c truy c\u1eadp mi\u1ec5n ph\u00ed.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Caspase-1%20Engages%20Full-Length%20Gasdermin%20D%20through%20Two%20Distinct%20Interfaces%20That%20Mediate%20Caspase%20Recruitment%20and%20Substrate%20Cleavage&amp;publication_year=2020&amp;author=Z.%20Liu&amp;author=C.%20Wang&amp;author=J.%20Yang&amp;author=Y.%20Chen&amp;author=B.%20Zhou&amp;author=D.W.%20Abbott&amp;author=T.S.%20Xiao\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref61\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib62\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib62\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[62]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">CW Davies, I. Stowe, QT Phung, H. Ho, CE Bakalarski, A. Gupta, Y. Zhang, JR Lill, J. Payandeh, N. Kayagaki, JT Koerber<\/div>\n<div id=\"ref-id-sbref62\" class=\"title text-m\">Vi\u1ec7c ph\u00e1t hi\u1ec7n ra kh\u00e1ng th\u1ec3 m\u00f4-\u0111un ph\u00e2n t\u00e1ch caspase cho th\u1ea5y nh\u1eefng hi\u1ec3u bi\u1ebft s\u00e2u s\u1eafc v\u1ec1 ch\u1ee9c n\u0103ng h\u1ed3ng c\u1ea7u phi n\u00fai<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Proc. Natl. H\u1ecdc vi\u1ec7n. Khoa h\u1ecdc. Hoa K\u1ef3, 118 (12) (2021), \u0110i\u1ec1u e2018024118,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1073\/pnas.2018024118\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1073\/pnas.2018024118<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85102705479&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref62\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Discovery%20of%20a%20caspase%20cleavage%20motif%20antibody%20reveals%20insights%20into%20noncanonical%20inflammasome%20function&amp;publication_year=2021&amp;author=C.W.%20Davies&amp;author=I.%20Stowe&amp;author=Q.T.%20Phung&amp;author=H.%20Ho&amp;author=C.E.%20Bakalarski&amp;author=A.%20Gupta&amp;author=Y.%20Zhang&amp;author=J.R.%20Lill&amp;author=J.%20Payandeh&amp;author=N.%20Kayagaki&amp;author=J.T.%20Koerber\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref62\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib63\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib63\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[63]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">S. 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Immunol., 204 (12) (2020), trang 3063-3069,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.4049\/jimmunol.2000373\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.4049\/jimmunol.2000373<\/span><\/a><\/div>\n<div class=\"comment\">PMID: 32513874<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85086298206&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref63\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Function%20and%20Regulation%20of%20Noncanonical%20Caspase-4511%20Inflammasome&amp;publication_year=2020&amp;author=S.%20Matikainen&amp;author=T.A.%20Nyman&amp;author=W.%20Cypryk\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref63\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib64\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib64\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[64]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">CW Davies, I. 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Neurol., 325 (2020), \u0110i\u1ec1u 113139,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.expneurol.2019.113139\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.expneurol.2019.113139<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014488619302869\/pdfft?md5=c32009110f4a234e536f16bbd938c229&amp;pid=1-s2.0-S0014488619302869-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref84\"><span class=\"anchor-text\">Xem PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014488619302869\" aria-describedby=\"ref-id-sbref84\"><span class=\"anchor-text\">Xem b\u00e0i vi\u1ebft<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85076270980&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref84\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Long%20non-coding%20RNA%20MEG3%20promotes%20cerebral%20ischemia-reperfusion%20injury%20through%20increasing%20pyroptosis%20by%20targeting%20miR-485AIM2%20axis&amp;publication_year=2020&amp;author=J.%20Liang&amp;author=Q.%20Wang&amp;author=J.Q.%20Li&amp;author=T.%20Guo&amp;author=D.%20Yu\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref84\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib85\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib85\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[85]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">LQ Wang, YY Zheng, HJ Chu, XX Zhang, P. 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Joseph, PJ Jost, PP Juin, WJ Kaiser, M. Karin, T. Kaufmann, O. Kepp, A. Kimchi , RN Kitsis, DJ Klionsky, RA Knight, S. Kumar, SW Lee, JJ Lemasters, B. Levine, A. Linkermann, SA Lipton, RA Lockshin, C. L\u00f3pez-Ot\u00edn, SW Lowe, T. Luedde, E. Lugli , M. MacFarlane, F. Madeo, M. Malewicz, W. Malorni, G. Manic, JC Marine, SJ Martin, JC Martinou, JP Medema, P. Mehlen, P. Meier, S. Melino, EA Miao, JD Molkentin , UM Moll, C. Mu\u00f1oz-Pinedo, S. Nagata, G. Nu\u00f1ez, A. Oberst, M. Oren, M. Overholtzer, M. Pagano, T. Panaretakis, M. Pasparakis, JM Penninger, DM Pereira, S. Pervaiz, ME Peter, M. Piacentini, P. Pinton, JHM Prehn, H. Puthalakath, GA Rabinovich, M. Rehm, R. Rizzuto, CMP Rodrigues, DC Rubinsztein, T. Rudel, KM Ryan, E. Sayan, L. Scorrano, F. Shao, Y. Shi, J. Silke, HU Simon, A. Sistigu, BR Stockwell, A. Strasser, G. Szabadkai, SWG Tait, D. Tang, N. Tavernarakis, A. Thorburn, Y. Tsujimoto , B. Turk, T. Vanden Berghe, P. Vandenabeele, MG Vander Heiden, A. 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JPhysiol, 305 (1 Pt.1) (2013), trang C182-C189,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1152\/ajpcell.00086.2013\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1152\/ajpcell.00086.2013<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Xem PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">B\u00e0i vi\u1ebft n\u00e0y \u0111\u01b0\u1ee3c truy c\u1eadp mi\u1ec5n ph\u00ed.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-84880172305&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref95\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=NLRP3%20deletionprotects%20from%20hyperoxia%20-induced%20acute%20lung%20injury&amp;publication_year=2013&amp;author=J.%20Fukumoto&amp;author=I.%20Fukumoto&amp;author=P.T.%20Parthasarathy\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref95\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib97\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib97\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[97]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">PC Liao, LK Chao, JC Chou,\u00a0<em>et al.<\/em><\/div>\n<div id=\"ref-id-sbref96\" class=\"title text-m\">S\u1ef1 truy\u1ec1n t\u00edn hi\u1ec7u qua trung gian lipopolysacarit\/adenosine triphosphate trong vi\u1ec7c \u0111i\u1ec1u h\u00f2a bi\u1ec3u hi\u1ec7n protein NLRP3 v\u00e0 b\u00e0i ti\u1ebft interleukin-1 \u03b2 qua trung gian espase-1<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Vi\u00eam. 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Yu, T. Zhao, M. Liu, D. Cao, J. Li, Y. Li, M. Xia, X. Wang, T. Zheng, C. Liu, X. Mu, P. Sun<\/div>\n<div id=\"ref-id-sbref110\" class=\"title text-m\">Nh\u1eafm m\u1ee5c ti\u00eau d\u00f2ng si\u00eau nh\u1ecf NLRP3 trong \u0111i\u1ec1u tr\u1ecb t\u1ecbnh ti\u1ebfn c\u00e1c b\u1ec7nh v\u1ec1 h\u1ec7 th\u1ea7n kinh: b\u1ea3n c\u1eadp nh\u1eadt<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Front Pharm., 12 (2021), \u0110i\u1ec1u 707696,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.3389\/fphar.2021.707696\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.3389\/fphar.2021.707696<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85114828635&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref110\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Targeting%20NLRP3%20inflammasome%20in%20translational%20treatment%20of%20nervous%20system%20diseases%3A%20an%20update&amp;publication_year=2021&amp;author=Q.%20Yu&amp;author=T.%20Zhao&amp;author=M.%20Liu&amp;author=D.%20Cao&amp;author=J.%20Li&amp;author=Y.%20Li&amp;author=M.%20Xia&amp;author=X.%20Wang&amp;author=T.%20Zheng&amp;author=C.%20Liu&amp;author=X.%20Mu&amp;author=P.%20Sun\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref110\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib112\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib112\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[112]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">L. 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Neuroinflamm., 15 (1) (2018), tr. 242,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1186\/s12974-018-1282-6\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1186\/s12974-018-1282-6<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Xem PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">B\u00e0i vi\u1ebft n\u00e0y \u0111\u01b0\u1ee3c truy c\u1eadp mi\u1ec5n ph\u00ed.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85052498101&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref125\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Mitochondrial%20dysfunction%20induces%20NLRP3%20inflammasome%20activation%20during%20cerebral%20ischemiareperfusion%20injury&amp;publication_year=2018&amp;author=Z.%20Gong&amp;author=J.%20Pan&amp;author=Q.%20Shen&amp;author=M.%20Li&amp;author=Y.%20Peng\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref125\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib127\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib127\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[127]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">T. 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Zhu, KA Romano, L. Li, JA Buffa, N. Sangwan, P. Prakash, AN Tittle, XS Li, X. Fu, C. Androjna, AJ DiDonato, K. Brinson, BD Trapp, MA Fischbach, FE Rey, AM Hajjar, JA DiDonato, SL Hazen<\/div>\n<div id=\"ref-id-sbref128\" class=\"title text-m\">Vi khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng c\u1ee7a \u0111\u1ed9t qu\u1ef5 th\u00f4ng qua con \u0111\u01b0\u1eddng trimethylamine N-oxide<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Vi khu\u1ea9n ch\u1ee7 t\u1ebf b\u00e0o, 29 (7) (2021), trang 1199-1208,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.chom.2021.05.002\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.chom.2021.05.002<\/span><\/a><\/div>\n<div class=\"comment\">Epub 2021 Ng\u00e0y 16 th\u00e1ng 6. 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(Weinh. ), 8 (20) (2021), \u0110i\u1ec1u e2101526,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1002\/advs.202101526\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1002\/advs.202101526<\/span><\/a><\/div>\n<div class=\"comment\">Epub 2021 ng\u00e0y 26 th\u00e1ng 8. 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Rev., 98 (2) (2018), trang 813-880,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1152\/physrev.00011.2017\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1152\/physrev.00011.2017<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Xem PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">B\u00e0i vi\u1ebft n\u00e0y \u0111\u01b0\u1ee3c truy c\u1eadp mi\u1ec5n ph\u00ed.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85043579253&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref153\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Neuronal%20cell%20death&amp;publication_year=2018&amp;author=M.%20Fricker&amp;author=A.M.%20Tolkovsky&amp;author=V.%20Borutaite&amp;author=M.%20Coleman&amp;author=G.C.%20Brown\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref153\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib155\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib155\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[155]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">E. Sekerdag, I. Solaroglu, Y. Gursoy-Ozdemir<\/div>\n<div id=\"ref-id-sbref154\" class=\"title text-m\">C\u01a1 ch\u1ebf ch\u1ebft t\u1ebf b\u00e0o trong \u0111\u1ed9t qu\u1ef5 v\u00e0 c\u00e1c l\u1ef1a ch\u1ecdn \u0111i\u1ec1u tr\u1ecb t\u1ebf b\u00e0o v\u00e0 ph\u00e2n t\u1eed m\u1edbi<\/div>\n<\/div>\n<div class=\"host u-font-sans\">CurrNeuropharmacol, 16 (9) (2018), trang 1396-1415,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.2174\/1570159X16666180302115544\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.2174\/1570159X16666180302115544<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span><\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85052760195&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref154\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Cell%20death%20mechanisms%20in%20stroke%20and%20novel%20molecular%20and%20cellular%20treatment%20options&amp;publication_year=2018&amp;author=E.%20Sekerdag&amp;author=I.%20Solaroglu&amp;author=Y.%20Gursoy-Ozdemir\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref154\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib156\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib156\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[156]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">HL Wang, QH Chu, MB Xu, XL Chu, GQ Zheng<\/div>\n<div id=\"ref-id-sbref155\" class=\"title text-m\">Astragaloside IV trong \u0111i\u1ec1u tr\u1ecb thi\u1ebfu m\u00e1u n\u00e3o c\u1ee5c b\u1ed9 th\u1ef1c nghi\u1ec7m: b\u1eb1ng ch\u1ee9ng ti\u1ec1n l\u00e2m s\u00e0ng v\u00e0 c\u00e1c c\u01a1 ch\u1ebf c\u00f3 th\u1ec3<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Oxit. Med Cell Longev., 2017 (2017), \u0110i\u1ec1u 8424326,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1155\/2017\/8424326\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1155\/2017\/8424326<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85016128656&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref155\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Astragaloside%20IV%20for%20experimental%20focal%20cerebral%20ischemia%3A%20preclinical%20evidence%20and%20possible%20mechanisms&amp;publication_year=2017&amp;author=H.L.%20Wang&amp;author=Q.H.%20Zhou&amp;author=M.B.%20Xu&amp;author=X.L.%20Zhou&amp;author=G.Q.%20Zheng\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref155\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib157\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib157\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[157]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">H. Zhao, Y. Chen, H. Feng<\/div>\n<div id=\"ref-id-sbref156\" class=\"title text-m\">S\u1ef1 ch\u1ebft t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c l\u1eadp tr\u00ecnh li\u00ean quan \u0111\u1ebfn th\u1ee5 th\u1ec3 P2X7 trong sinh l\u00fd b\u1ec7nh c\u1ee7a \u0111\u1ed9t qu\u1ef5 xu\u1ea5t huy\u1ebft<\/div>\n<\/div>\n<div class=\"host u-font-sans\">CurrNeuropharmacol, 16 (9) (2018), trang 1282-1295,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.2174\/1570159X16666180516094500\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.2174\/1570159X16666180516094500<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span><\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85055080474&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref156\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=P2X7%20Receptor-Associated%20Programmed%20Cell%20Death%20in%20the%20Pathophysiology%20of%20Hemorrhagic%20Stroke&amp;publication_year=2018&amp;author=H.%20Zhao&amp;author=Y.%20Chen&amp;author=H.%20Feng\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref156\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib158\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib158\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[158]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">K. 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Jurajda<\/div>\n<div id=\"ref-id-sbref157\" class=\"title text-m\">Vai tr\u00f2 c\u1ee7a ph\u1ea3n \u1ee9ng vi\u00eam trong qu\u00e1 tr\u00ecnh ch\u1ebft t\u1ebf b\u00e0o theo ch\u01b0\u01a1ng tr\u00ecnh li\u00ean quan \u0111\u1ebfn \u0111\u1ed9t qu\u1ef5<\/div>\n<\/div>\n<div class=\"host u-font-sans\">CurrNeuropharmacol, 16 (9) (2018), trang 1365-1374,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.2174\/1570159X16666180222155833\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.2174\/1570159X16666180222155833<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span><\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85055080999&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref157\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=The%20Role%20of%20Inflammatory%20Response%20in%20Stroke%20Associated%20Programmed%20Cell%20Death&amp;publication_year=2018&amp;author=K.%20Duris&amp;author=Z.%20Splichal&amp;author=M.%20Jurajda\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref157\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib159\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib159\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[159]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">DY Fann, EP Nickles, L. 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Med, 23 (6) (2017), trang 512-533,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.molmed.2017.03.008\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.molmed.2017.03.008<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1471491417300473\/pdfft?md5=493d5864859705788e3932a88a92a5b1&amp;pid=1-s2.0-S1471491417300473-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref160\"><span class=\"anchor-text\">Xem PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1471491417300473\" aria-describedby=\"ref-id-sbref160\"><span class=\"anchor-text\">Xem b\u00e0i vi\u1ebft<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85018795527&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref160\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=TREM2%2C%20microglia%2C%20and%20neurodegenerative%20diseases&amp;publication_year=2017&amp;author=F.L.%20Yeh&amp;author=D.V.%20Hansen&amp;author=M.%20Sheng\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref160\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib162\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib162\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[162]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">V. Kumar<\/div>\n<div id=\"ref-id-sbref161\" class=\"title text-m\">C\u00e1c th\u1ee5 th\u1ec3 gi\u1ed1ng nh\u01b0 thu ph\u00ed trong c\u01a1 ch\u1ebf b\u1ec7nh sinh c\u1ee7a vi\u00eam th\u1ea7n kinh<\/div>\n<\/div>\n<div class=\"host u-font-sans\">J. Neuroimmunol., 332 (2019), trang 16-30,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.jneuroim.2019.03.012\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.jneuroim.2019.03.012<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S016557281930058X\/pdfft?md5=a4fe2352aa1b05da9ea79a3291e970ec&amp;pid=1-s2.0-S016557281930058X-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref161\"><span class=\"anchor-text\">Xem PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S016557281930058X\" aria-describedby=\"ref-id-sbref161\"><span class=\"anchor-text\">Xem b\u00e0i vi\u1ebft<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85063536274&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref161\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Toll-like%20receptors%20in%20the%20pathogenesis%20of%20neuroinflammation&amp;publication_year=2019&amp;author=V.%20Kumar\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref161\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib163\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib163\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[163]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">Z. Zhu, L. Zheng, Y. Li, T. Huang, YC Chao, L. Pan, H. Zhu, Y. Zhao, W. Yu, P. Li<\/div>\n<div id=\"ref-id-sbref162\" class=\"title text-m\">C\u00e1c m\u1ee5c ti\u00eau tr\u1ecb li\u1ec7u mi\u1ec5n d\u1ecbch ti\u1ec1m n\u0103ng tr\u00ean c\u00e1c t\u1ebf b\u00e0o t\u1ee7y \u0111\u1ec3 s\u1eeda ch\u1eefa th\u1ea7n kinh m\u1ea1ch m\u00e1u sau \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Front Neurosci., 13 (2019), tr. 758,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.3389\/fnins.2019.00758\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.3389\/finins.2019.00758<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85070612620&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref162\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Potential%20Immunotherapeutic%20Targets%20on%20Myeloid%20Cells%20for%20Neurovascular%20Repair%20After%20Ischemic%20Stroke&amp;publication_year=2019&amp;author=Z.%20Zhu&amp;author=L.%20Zheng&amp;author=Y.%20Li&amp;author=T.%20Huang&amp;author=Y.C.%20Chao&amp;author=L.%20Pan&amp;author=H.%20Zhu&amp;author=Y.%20Zhao&amp;author=W.%20Yu&amp;author=P.%20Li\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref162\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib164\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib164\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[164]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">DY Fann, YA Lim, YL Cheng, KZ Lok, P. 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Neurobiol., 55 (2) (2018), trang 1082-1096,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1007\/s12035-017-0394-9\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1007\/s12035-017-0394-9<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85009437506&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref163\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Evidence%20that%20NF-B%20and%20MAPK%20Signaling%20Promotes%20NLRP%20Inflammasome%20Activation%20in%20Neurons%20Following%20Ischemic%20Stroke&amp;publication_year=2018&amp;author=D.Y.%20Fann&amp;author=Y.A.%20Lim&amp;author=Y.L.%20Cheng&amp;author=K.Z.%20Lok&amp;author=P.%20Chunduri&amp;author=S.H.%20Baik&amp;author=G.R.%20Drummond&amp;author=S.T.%20Dheen&amp;author=C.G.%20Sobey&amp;author=D.G.%20Jo&amp;author=C.L.%20Chen&amp;author=T.V.%20Arumugam\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref163\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib165\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib165\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[165]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">J. 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Neurol., 325 (2020), \u0110i\u1ec1u 113139,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.expneurol.2019.113139\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.expneurol.2019.113139<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014488619302869\/pdfft?md5=c32009110f4a234e536f16bbd938c229&amp;pid=1-s2.0-S0014488619302869-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref165\"><span class=\"anchor-text\">Xem PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014488619302869\" aria-describedby=\"ref-id-sbref165\"><span class=\"anchor-text\">Xem b\u00e0i vi\u1ebft<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85076270980&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref165\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Long%20non-coding%20RNA%20MEG3%20promotes%20cerebral%20ischemia-reperfusion%20injury%20through%20increasing%20pyroptosis%20by%20targeting%20miR-485AIM2%20axis&amp;publication_year=2020&amp;author=J.%20Liang&amp;author=Q.%20Wang&amp;author=J.Q.%20Li&amp;author=T.%20Guo&amp;author=D.%20Yu\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref165\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib167\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib167\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[167]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">D. 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Neurobiol., 130 (2015), trang 86-120<\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0301008215000374\/pdfft?md5=1559dfe9f57d972ab95684120a559165&amp;pid=1-s2.0-S0301008215000374-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref166\"><span class=\"anchor-text\">Xem PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0301008215000374\" aria-describedby=\"ref-id-sbref166\"><span class=\"anchor-text\">Xem b\u00e0i vi\u1ebft<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-84931564272&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref166\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Astrocyte%20physiopathology%3A%20At%20the%20crossroads%20of%20intercellular%20networking%2C%20inflammation%20and%20cell%20death&amp;publication_year=2015&amp;author=D.%20Rossi\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref166\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib168\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib168\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[168]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">Sim NR, WP Yew<\/div>\n<div id=\"ref-id-sbref167\" class=\"title text-m\">Ch\u1ee9ng astrogliosis ph\u1ea3n \u1ee9ng trong \u0111\u1ed9t qu\u1ef5: S\u1ef1 \u0111\u00f3ng g\u00f3p c\u1ee7a t\u1ebf b\u00e0o h\u00ecnh sao trong vi\u1ec7c ph\u1ee5c h\u1ed3i ch\u1ee9c n\u0103ng th\u1ea7n kinh<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Neurochem Int, 107 (2017), trang 88-103,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.neuint.2016.12.016\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.neuint.2016.12.016<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0197018616303874\/pdfft?md5=7ac67d036f93d7e49973d9f05bd1df1a&amp;pid=1-s2.0-S0197018616303874-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref167\"><span class=\"anchor-text\">Xem PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0197018616303874\" aria-describedby=\"ref-id-sbref167\"><span class=\"anchor-text\">Xem b\u00e0i vi\u1ebft<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85009483754&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref167\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Reactive%20astrogliosis%20in%20stroke%3A%20Contributions%20of%20astrocytes%20to%20recovery%20of%20neurological%20function&amp;publication_year=2017&amp;author=N.R.%20Sims&amp;author=W.P.%20Yew\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref167\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib169\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib169\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[169]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">SL Macauley, M. 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Zhang, N. Jiang, L. Zhang, C. Meng, J. Zhao, J. 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Neurobiol., 42 (5) (2022), trang 1487-1500,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1007\/s10571-021-01040-3\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1007\/s10571-021-01040-3<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85101234736&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref190\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=MircoRNA-29a%20in%20Astrocyte-derived%20Extracellular%20Vesicles%20Suppresses%20Brain%20Ischemia%20Reperfusion%20Injury%20via%20TP53INP1%20and%20the%20NF-BNLRP3%20Axis&amp;publication_year=2022&amp;author=X.%20Liu&amp;author=X.%20Lv&amp;author=Z.%20Liu&amp;author=M.%20Zhang&amp;author=Y.%20Leng\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref190\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib192\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib192\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[192]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">YB Liang, PP Song, YH Zhu, JM Xu, PZ Zhu, RR Liu, YS Zhang<\/div>\n<div id=\"ref-id-sbref191\" class=\"title text-m\">LP17 nh\u1eafm m\u1ee5c ti\u00eau TREM-1 l\u00e0m gi\u1ea3m t\u1ed5n th\u01b0\u01a1ng t\u1ebf b\u00e0o th\u1ea7n kinh do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 n\u00e3o b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf stress oxy h\u00f3a v\u00e0 ch\u1ee9ng pyroptosis<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Sinh h\u00f3a sinh h\u1ecdc. Res Commun., 529 (3) (2020), trang 554-561,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.bbrc.2020.05.056\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.bbrc.2020.05.056<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006291X20309645\/pdfft?md5=8c05cfaed5cd8eebadcbfbb39e440900&amp;pid=1-s2.0-S0006291X20309645-mainext.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref191\"><span class=\"anchor-text\">Xem PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006291X20309645\" aria-describedby=\"ref-id-sbref191\"><span class=\"anchor-text\">Xem b\u00e0i vi\u1ebft<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85087844924&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref191\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=TREM-1-targeting%20LP17%20attenuates%20cerebral%20ischemia-induced%20neuronal%20injury%20by%20inhibiting%20oxidative%20stress%20and%20pyroptosis&amp;publication_year=2020&amp;author=Y.B.%20Liang&amp;author=P.P.%20Song&amp;author=Y.H.%20Zhu&amp;author=J.M.%20Xu&amp;author=P.Z.%20Zhu&amp;author=R.R.%20Liu&amp;author=Y.S.%20Zhang\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref191\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib193\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib193\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[193]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">P. 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Neuroinflamm., 17 (1) (2020), tr. 330,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1186\/s12974-020-01988-x\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1186\/s12974-020-01988-x<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Xem PDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">B\u00e0i vi\u1ebft n\u00e0y \u0111\u01b0\u1ee3c truy c\u1eadp mi\u1ec5n ph\u00ed.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85095116758&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref193\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Low-density%20lipoprotein%20receptor%20%20regulates%20NLRP3-mediated%20neuronal%20pyroptosis%20following%20cerebral%20ischemiareperfusion%20injury&amp;publication_year=2020&amp;author=R.%20Sun&amp;author=M.%20Peng&amp;author=P.%20Xu&amp;author=F.%20Huang&amp;author=Y.%20Xie&amp;author=J.%20Li&amp;author=Y.%20Hong&amp;author=H.%20Guo&amp;author=Q.%20Liu&amp;author=W.%20Zhu\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref193\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib195\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib195\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[195]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">Y. 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Gao<\/div>\n<div id=\"ref-id-sbref195\" class=\"title text-m\">S\u1ef1 bi\u1ec3u hi\u1ec7n qu\u00e1 m\u1ee9c CHRFAM7A l\u00e0m gi\u1ea3m t\u1ed5n th\u01b0\u01a1ng t\u00e1i t\u01b0\u1edbi m\u00e1u do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 n\u00e3o th\u00f4ng qua vi\u1ec7c \u1ee9c ch\u1ebf b\u1ec7nh pyroptosis microglia qua trung gian con \u0111\u01b0\u1eddng NLRP3 \/ Caspase-1<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Vi\u00eam, 44 (3) (2021), trang 1023-1034,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1007\/s10753-020-01398-4\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1007\/s10753-020-01398-4<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85099180923&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref195\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=CHRFAM7A%20overexpression%20attenuates%20cerebral%20ischemia-reperfusion%20injury%20via%20inhibiting%20microglia%20pyroptosis%20mediated%20by%20the%20NLRP3Caspase-1%20pathway&amp;publication_year=2021&amp;author=X.%20Cao&amp;author=Y.%20Wang&amp;author=L.%20Gao\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref195\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib197\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib197\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[197]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">LL Tan, XL Jiang, LX Xu, G. 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Ngh\u1ecb quy\u1ebft, 16 (6) (2021), trang 1037-1043,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.4103\/1673-5374.300453\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.4103\/1673-5374.300453<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85097393831&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref196\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=TP53-induced%20glycolysis%20and%20apoptosis%20regulator%20alleviates%20hypoxiaischemia-induced%20microglial%20pyroptosis%20and%20ischemic%20brain%20damage&amp;publication_year=2021&amp;author=L.L.%20Tan&amp;author=X.L.%20Jiang&amp;author=L.X.%20Xu&amp;author=G.%20Li&amp;author=C.X.%20Feng&amp;author=X.%20Ding&amp;author=B.%20Sun&amp;author=Z.H.%20Qin&amp;author=Z.B.%20Zhang&amp;author=X.%20Feng&amp;author=M.%20Li\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref196\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib198\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib198\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[198]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">X. 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Ethnopharmacol., 270 (2021), \u0110i\u1ec1u 113776,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.jep.2021.113776\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.jep.2021.113776<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874121000027\/pdfft?md5=c27ebe26e91dd8eb1eb175405c9de391&amp;pid=1-s2.0-S0378874121000027-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref212\"><span class=\"anchor-text\">Xem PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874121000027\" aria-describedby=\"ref-id-sbref212\"><span class=\"anchor-text\">Xem b\u00e0i vi\u1ebft<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85099133521&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref212\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Salvianolic%20Acids%20for%20Injection%20alleviates%20cerebral%20ischemiareperfusion%20injury%20by%20switching%20M1M2%20phenotypes%20and%20inhibiting%20NLRP3%20inflammasomepyroptosis%20axis%20in%20microglia%20in%20vivo%20and%20in%20vitro&amp;publication_year=2021&amp;author=D.C.%20Ma&amp;author=N.N.%20Zhang&amp;author=Y.N.%20Zhang&amp;author=H.S.%20Chen\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref212\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib214\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib214\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[214]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">P. 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DevelTher, 14 (2020), trang 3731-3746,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.2147\/DDDT.S272355\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.2147\/DDDT.S272355<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">Xem PDF<\/span><\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">B\u00e0i vi\u1ebft n\u00e0y \u0111\u01b0\u1ee3c truy c\u1eadp mi\u1ec5n ph\u00ed.<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85090878978&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref217\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=An%20effective%20drug%20for%20the%20treatment%20of%20cardiovascular%20diseases&amp;publication_year=2020&amp;author=Y.Q.%20Tan&amp;author=H.W.%20Chen&amp;author=J.%20Li&amp;author=I.V.%20Astragaloside\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref217\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib219\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib219\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[219]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">A. Datta, D. Sarmah, L. Mounica, H. Kaur, R. Kesharwani, G. Verma, P. Veeresh, V. Kotian, K. Kalia, A. Borah, X. Wang, KR Dave, DR Yavagal, P. 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Yang, L. Zeng, A. Ge, Y. Chen, S. Wang, X. Zhu, J. Ge<\/div>\n<div id=\"ref-id-sbref219\" class=\"title text-m\">Kh\u00e1m ph\u00e1 c\u01a1 ch\u1ebf \u0111i\u1ec1u h\u00f2a c\u1ee7a h\u1ee3p ch\u1ea5t HedysarumMultijugumMaxim.-Chuanxiong Rhizoma tr\u00ean con \u0111\u01b0\u1eddng HIF-VEGF v\u00e0 m\u1ea1ng l\u01b0\u1edbi sinh h\u1ecdc c\u1ee7a t\u1ed5n th\u01b0\u01a1ng do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9-t\u00e1i t\u01b0\u1edbi m\u00e1u n\u00e3o d\u1ef1a tr\u00ean d\u01b0\u1ee3c l\u00fd h\u1ecdc c\u00f3 h\u1ec7 th\u1ed1ng<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Front Pharmacol., 12 (2021), \u0110i\u1ec1u 601846,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.3389\/fphar.2021.601846\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.3389\/fphar.2021.601846<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85109788788&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref219\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Exploring%20the%20regulatory%20mechanism%20of%20HedysarumMultijugumMaxim.-Chuanxiong%20Rhizoma%20compound%20on%20HIF-VEGF%20pathway%20and%20cerebral%20ischemia-reperfusion%20injurys%20biological%20network%20based%20on%20systematic%20pharmacology&amp;publication_year=2021&amp;author=K.%20Yang&amp;author=L.%20Zeng&amp;author=A.%20Ge&amp;author=Y.%20Chen&amp;author=S.%20Wang&amp;author=X.%20Zhu&amp;author=J.%20Ge\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref219\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib221\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib221\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[221]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">G. Wang, X. Zeng, K. Yang, S. Gong, A. Ge, W. Liu, Q. He, W. Zhang, J. Ge<\/div>\n<div id=\"ref-id-sbref220\" class=\"title text-m\">Kh\u00e1m ph\u00e1 t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 th\u1ea7n kinh c\u1ee7a h\u1ee3p ch\u1ea5t th\u00e2n r\u1ec5 hedysarummultijugum maxim-chuanxiong \u0111\u1ed1i v\u1edbi nh\u1ed3i m\u00e1u n\u00e3o th\u00f4ng qua nghi\u00ean c\u1ee9u \u0111\u1ecbnh l\u01b0\u1ee3ng proteomics<\/div>\n<\/div>\n<div class=\"host u-font-sans\">R\u00f5 r\u00e0ng. D\u1ef1a tr\u00ean b\u1ed5 sung thay th\u1ebf. Med., 2022 (2022), \u0110i\u1ec1u 5241902,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1155\/2022\/5241902\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1155\/2022\/5241902<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85128414552&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref220\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Uncovering%20the%20neuroprotective%20effect%20of%20hedysarummultijugum%20maxim-chuanxiong%20rhizoma%20compound%20on%20cerebral%20infarction%20through%20quantitative%20proteomics&amp;publication_year=2022&amp;author=G.%20Wang&amp;author=X.%20Zeng&amp;author=K.%20Yang&amp;author=S.%20Gong&amp;author=A.%20Ge&amp;author=W.%20Liu&amp;author=Q.%20He&amp;author=W.%20Zhang&amp;author=J.%20Ge\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref220\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib222\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib222\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[222]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">K. Yang, L. Zeng, A. Ge, Y. Shi, X. Zhu, W. Liu, J. Ge<\/div>\n<div id=\"ref-id-sbref221\" class=\"title text-m\">T\u00e1c d\u1ee5ng c\u1ee7a h\u1ee3p ch\u1ea5t th\u00e2n r\u1ec5 hedysarummultijugummaxim.-Chuanxiong \u0111\u1ed1i v\u1edbi \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9: m\u1ed9t nghi\u00ean c\u1ee9u d\u1ef1a tr\u00ean m\u1ea1ng l\u01b0\u1edbi v\u00e0 d\u01b0\u1ee3c l\u00fd th\u1ef1c nghi\u1ec7m<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Oxit. Med. 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Sun<\/div>\n<div id=\"ref-id-sbref224\" class=\"title text-m\">Panax notoginseng saponin: \u0111\u00e1nh gi\u00e1 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng ch\u1ed1ng tr\u1ea7m c\u1ea3m ho\u1eb7c gi\u1ea3i lo \u00e2u v\u00e0 ph\u00e2n t\u00edch m\u1ea1ng l\u01b0\u1edbi v\u1ec1 h\u00f3a th\u1ef1c v\u1eadt v\u00e0 d\u01b0\u1ee3c l\u00fd<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Ph\u00e2n t\u1eed, 23 (4) (2018), tr. 940,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.3390\/molecules23040940\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.3390\/ph\u00e2n t\u1eed23040940<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85045663855&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref224\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Panax%20notoginseng%20saponins%3A%20a%20review%20of%20its%20mechanisms%20of%20antidepressant%20or%20anxiolytic%20effects%20and%20network%20analysis%20on%20phytochemistry%20and%20pharmacology&amp;publication_year=2018&amp;author=W.%20Xie&amp;author=X.%20Meng&amp;author=Y.%20Zhai&amp;author=P.%20Zhou&amp;author=T.%20Ye&amp;author=Z.%20Wang&amp;author=G.%20Sun&amp;author=X.%20Sun\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref224\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib226\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib226\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[226]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">J. Qu, N. Xu, J. Zhang, X. Geng, R. Zhang<\/div>\n<div id=\"ref-id-sbref225\" class=\"title text-m\">Saponin Panax notoginseng v\u00e0 \u1ee9ng d\u1ee5ng c\u1ee7a ch\u00fang trong c\u00e1c r\u1ed1i lo\u1ea1n h\u1ec7 th\u1ea7n kinh: t\u1ed5ng quan t\u01b0\u1eddng thu\u1eadt<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Ann. D\u1ecbch. 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Liu, X. Lu, Y. Hu, X. Fan<\/div>\n<div id=\"ref-id-sbref226\" class=\"title text-m\">Th\u00e0nh ph\u1ea7n h\u00f3a h\u1ecdc c\u1ee7a Nh\u00e2n s\u00e2m Panax v\u00e0 Panax notoginseng gi\u1ea3i th\u00edch t\u1ea1i sao ch\u00fang kh\u00e1c nhau v\u1ec1 hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb<\/div>\n<\/div>\n<div class=\"host u-font-sans\">D\u01b0\u1ee3c ph\u1ea9m. Ngh\u1ecb quy\u1ebft, 161 (2020), \u0110i\u1ec1u 105263,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.phrs.2020.105263\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.phrs.2020.105263<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1043661820315711\/pdfft?md5=f06179b256e8e23dd685c57247f67d5e&amp;pid=1-s2.0-S1043661820315711-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref226\"><span class=\"anchor-text\">Xem PDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1043661820315711\" aria-describedby=\"ref-id-sbref226\"><span class=\"anchor-text\">Xem b\u00e0i vi\u1ebft<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85095773224&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref226\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Chemical%20constituents%20of%20Panax%20ginseng%20and%20Panax%20notoginseng%20explain%20why%20they%20differ%20in%20therapeutic%20efficacy&amp;publication_year=2020&amp;author=H.%20Liu&amp;author=X.%20Lu&amp;author=Y.%20Hu&amp;author=X.%20Fan\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref226\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib228\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib228\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[228]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">H\u00e0 H\u00fac, C\u00e1t Kim V\u0103n, \u0110\u1eb7ng Tr\u01b0\u1eddng Thanh, Qu\u00e1ch Th\u00e1i B\u00ecnh, Phan \u00c1i Hoa, L\u00fd. Ch\u00ed Vi\u1ec5n Panax<\/div>\n<div id=\"ref-id-sbref227\" class=\"title text-m\">Saponin notoginseng \u1ee9c ch\u1ebf qu\u00e1 tr\u00ecnh apoptosis c\u1ee7a t\u1ebf b\u00e0o th\u1ea7n kinh \u1edf v\u00f9ng CA1 v\u00f9ng \u0111\u1ed3i th\u1ecb sau thi\u1ebfu m\u00e1u n\u00e3o c\u1ee5c b\u1ed9 to\u00e0n c\u1ea7u v\u00e0 c\u01a1 ch\u1ebf c\u1ee7a n\u00f3<\/div>\n<\/div>\n<div class=\"host u-font-sans\">C\u00e1i c\u1eb1m. Th\u1ea3o m\u1ed9c. 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C\u00e1i c\u1eb1m. Med. (2019),\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.27138\/d.cnki.ghuzc.2019.000014\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.27138\/d.cnki.ghuzc.2019.000014<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=The%20role%20of%20mitophagy-NLRP3%20inflammasome%20pathway%20in%20cerebral%20ischemia-reperfusion%20injury%20and%20the%20intervention%20of%20Panax%20notoginseng%20saponins%20and%20astragaloside%20IVD&amp;publication_year=2019&amp;author=Tang%20Biao\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref231\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib233\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib233\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[233]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">Chu Anh<\/div>\n<div id=\"ref-id-sbref232\" class=\"title text-m\">T\u00e1c d\u1ee5ng v\u00e0 c\u01a1 ch\u1ebf c\u1ee7a thu\u1ed1c s\u1eafc Taohong Siwu \u0111\u1ed1i v\u1edbi b\u1ec7nh pyroptosis sau nh\u1ed3i m\u00e1u n\u00e3o c\u1ea5p t\u00ednh d\u1ef1a tr\u00ean con \u0111\u01b0\u1eddng DRP1\/NLRP3[D]<\/div>\n<\/div>\n<div class=\"host u-font-sans\">\u0110\u1ea1i h\u1ecdc B\u1eafc Kinh Truy\u1ec1n th\u1ed1ng. 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(2019),\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.27138\/d.cnki.ghuzc.2019.000152\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.27138\/d.cnki.ghuzc.2019.000152<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Study%20on%20the%20protective%20effect%20of%20Shennao%20Fuyuan%20decoction%20on%20PC12%20cells%20deficient%20in%20glucose%20and%20oxygen%20based%20on%20the%20mechanism%20of%20cell%20pyroptosis%20D&amp;publication_year=2019&amp;author=Xin%20Li\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref249\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib251\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib251\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[251]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">R. Yang, X. Zhang<\/div>\n<div id=\"ref-id-sbref250\" class=\"title text-m\">M\u1ed9t con \u0111\u01b0\u1eddng m\u1edbi ti\u1ec1m n\u0103ng trong \u0111i\u1ec1u tr\u1ecb b\u1eb1ng heparin \u0111\u1ed1i v\u1edbi t\u1ed5n th\u01b0\u01a1ng ph\u1ed5i do nhi\u1ec5m tr\u00f9ng huy\u1ebft: \u1ee9c ch\u1ebf ch\u1ee9ng pyroptosis t\u1ebf b\u00e0o n\u1ed9i m\u00f4 ph\u1ed5i b\u1eb1ng c\u00e1ch ng\u0103n ch\u1eb7n ho\u1ea1t h\u00f3a caspase-11 do hMGB1-LPS g\u00e2y ra<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Nhi\u1ec5m tr\u00f9ng t\u1ebf b\u00e0o ph\u00eda tr\u01b0\u1edbc. Microbiol., 12 (2022), \u0110i\u1ec1u 984835,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.3389\/fcimb.2022.984835\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.3389\/fcimb.2022.984835<\/span><\/a><\/div>\n<div class=\"comment\">PMID: 36189354; PMCID: PMC9519888.<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85139032884&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref250\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=A%20potential%20new%20pathway%20for%20heparin%20treatment%20of%20sepsis-induced%20lung%20injury%3A%20inhibition%20of%20pulmonary%20endothelial%20cell%20pyroptosis%20by%20blocking%20hMGB1-LPS-induced%20caspase-11%20activation&amp;publication_year=2022&amp;author=R.%20Yang&amp;author=X.%20Zhang\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref250\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib252\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib252\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[252]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">A. 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Pharm., 55 (3) (2004), trang 563-574<\/div>\n<div class=\"comment\">PMID: 15381827<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-4844228829&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref255\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Antithrombotic%20effect%20of%20L-arginine%20in%20hypertensive%20rats&amp;publication_year=2004&amp;author=D.%20Cylwik&amp;author=A.%20Mogielnicki&amp;author=K.%20Kramkowski&amp;author=J.%20Stokowski&amp;author=W.%20Buczko\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref255\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib257\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib257\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[257]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">SA Tanuseputero, MT Lin, SL Yeh, CL Yeh<\/div>\n<div id=\"ref-id-sbref256\" class=\"title text-m\">Qu\u1ea3n l\u00fd Arginine ti\u00eam t\u0129nh m\u1ea1ch \u0111i\u1ec1u h\u00f2a ho\u1ea1t \u0111\u1ed9ng c\u1ee7a t\u1ebf b\u00e0o NLRP3 v\u00e0 l\u00e0m gi\u1ea3m t\u1ed5n th\u01b0\u01a1ng th\u1eadn c\u1ea5p t\u00ednh \u1edf chu\u1ed9t b\u1ecb nhi\u1ec5m tr\u00f9ng huy\u1ebft \u0111a vi khu\u1ea9n<\/div>\n<\/div>\n<div class=\"host u-font-sans\">H\u00f2a gi\u1ea3i. Inflamm., 2020 (2020), \u0110i\u1ec1u 3201635,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1155\/2020\/3201635\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1155\/2020\/3201635<\/span><\/a><\/div>\n<div class=\"comment\">PMID: 32454788; PMCID: PMC7238342.<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">Xem b\u00e0i vi\u1ebft<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85085510204&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref256\"><span class=\"anchor-text\">Xem trong Scopus<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Intravenous%20Arginine%20Administration%20Downregulates%20NLRP3%20inflammasome%20activity%20and%20attenuates%20acute%20kidney%20injury%20in%20mice%20with%20polymicrobial%20sepsis&amp;publication_year=2020&amp;author=S.A.%20Tanuseputero&amp;author=M.T.%20Lin&amp;author=S.L.%20Yeh&amp;author=C.L.%20Yeh\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref256\"><span class=\"anchor-text\">H\u1ecdc gi\u1ea3 Google<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<\/ol>\n<\/section>\n<\/section>\n<div id=\"section-cited-by\">\n<section class=\"ListArticles preview\" aria-label=\"Tr\u00edch d\u1eabn\">\n<div class=\"PageDivider\"><\/div>\n<header id=\"citing-articles-header\">\n<h2 class=\"u-h4 u-margin-l-ver u-font-serif\">\u0110\u01b0\u1ee3c tr\u00edch d\u1eabn b\u1edfi (7)<\/h2>\n<\/header>\n<div aria-describedby=\"citing-articles-header\">\n<div class=\"citing-articles u-margin-l-bottom\">\n<ul>\n<li class=\"ListArticleItem u-margin-l-bottom\">\n<div class=\"sub-heading u-margin-xs-bottom\">\n<p id=\"citing-articles-article-0-title\" class=\"u-font-serif\"><a class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874123009492\"><span class=\"anchor-text\">Chi\u1ebft xu\u1ea5t Bombyx batryticatus k\u00edch ho\u1ea1t y\u1ebfu t\u1ed1 \u0111\u00f4ng m\u00e1u \u216b \u0111\u1ec3 th\u00fac \u0111\u1ea9y s\u1ef1 h\u00ecnh th\u00e0nh m\u1ea1ch \u1edf chu\u1ed9t b\u1ecb t\u1ed5n th\u01b0\u01a1ng do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9\/t\u00e1i t\u01b0\u1edbi m\u00e1u n\u00e3o<\/span><\/a><\/p>\n<div class=\"text-s\">2024, T\u1ea1p ch\u00ed D\u00e2n t\u1ed9c h\u1ecdc<\/div>\n<\/div>\n<div class=\"buttons text-s\">\n<p>&nbsp;<\/p>\n<\/div>\n<\/li>\n<li class=\"ListArticleItem u-margin-l-bottom\">\n<div class=\"sub-heading u-margin-xs-bottom\">\n<p id=\"citing-articles-article-1-title\" class=\"u-font-serif\"><a class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874123008589\"><span class=\"anchor-text\">T\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 th\u1ea7n kinh c\u1ee7a thu\u1ed1c s\u1eafc Jie-du-huo-xue \u0111\u1ed1i v\u1edbi ch\u1ee9ng pyroptosis microglia sau thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 n\u00e3o v\u00e0 t\u00e1i t\u01b0\u1edbi m\u00e1u\u2014\u2014T\u1eeb g\u00f3c \u0111\u1ed9 c\u1ee7a \u0111\u01a1n v\u1ecb m\u1ea1ch m\u00e1u th\u1ea7n kinh \u0111\u1ec7m<\/span><\/a><\/p>\n<div class=\"text-s\">2024, T\u1ea1p ch\u00ed D\u00e2n t\u1ed9c h\u1ecdc<\/div>\n<\/div>\n<div class=\"buttons text-s\">\n<p>&nbsp;<\/p>\n<\/div>\n<\/li>\n<li class=\"ListArticleItem u-margin-l-bottom\">\n<div class=\"sub-heading u-margin-xs-bottom\">\n<p id=\"citing-articles-article-2-title\" class=\"u-font-serif\"><a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.21203\/rs.3.rs-3691555\/v1\" target=\"_blank\" rel=\"noopener\"><span class=\"anchor-text\">Ph\u00e2n t\u00edch h\u1ecdc m\u00e1y v\u1ec1 h\u1ed3 s\u01a1 bi\u1ec3u hi\u1ec7n gen c\u1ee7a c\u00e1c gen bi\u1ec3u hi\u1ec7n kh\u00e1c bi\u1ec7t li\u00ean quan \u0111\u1ebfn b\u1ec7nh Pyroptosis trong thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 \u0111\u00e3 ti\u1ebft l\u1ed9 c\u00e1c m\u1ee5c ti\u00eau ti\u1ec1m n\u0103ng \u0111\u1ec3 t\u00e1i s\u1eed d\u1ee5ng thu\u1ed1c<\/span><\/a><\/p>\n<div class=\"text-s\">2023, Qu\u1ea3ng tr\u01b0\u1eddng Nghi\u00ean c\u1ee9u<\/div>\n<\/div>\n<div class=\"buttons text-s\"><\/div>\n<\/li>\n<li class=\"ListArticleItem u-margin-l-bottom\">\n<div class=\"sub-heading u-margin-xs-bottom\">\n<p id=\"citing-articles-article-3-title\" class=\"u-font-serif\"><a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1002\/ptr.7994\" target=\"_blank\" rel=\"noopener\"><span class=\"anchor-text\">Nh\u1eefng ti\u1ebfn b\u1ed9 c\u1ee7a li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o h\u1ecdc trong \u0111i\u1ec1u tr\u1ecb \u0111\u1ed9t qu\u1ef5 do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 nh\u1eafm v\u00e0o t\u00edn hi\u1ec7u PI3K\/Akt<\/span><\/a><\/p>\n<div class=\"text-s\">2023, Nghi\u00ean c\u1ee9u t\u1ebf b\u00e0o h\u1ecdc<\/div>\n<\/div>\n<div class=\"buttons text-s\"><\/div>\n<\/li>\n<\/ul>\n<\/div>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889\">Ngu\u1ed3n<\/a><\/p>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>This suggests that breviscapine may significantly improve the cognitive function of CCI rats and reduce the pathological damage of ischemic neurons, and its mechanism may be related to the inhibition of NLRP3 inflammasome activation and pyroptosis pathway in brain tissue [211].<\/p>","protected":false},"author":1,"featured_media":5371,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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