{"id":4897,"date":"2024-01-15T06:31:30","date_gmt":"2024-01-15T06:31:30","guid":{"rendered":"https:\/\/corp.farlong.com\/the-effect-of-proto-type-wearable-light-emitting-devices-on-serum-25-hydroxyvitamin-d-levels-in-healthy-adults-a-4-week-randomized-controlled-trial\/"},"modified":"2024-01-27T10:17:53","modified_gmt":"2024-01-27T10:17:53","slug":"the-effect-of-proto-type-wearable-light-emitting-devices-on-serum-25-hydroxyvitamin-d-levels-in-healthy-adults-a-4-week-randomized-controlled-trial","status":"publish","type":"post","link":"https:\/\/directcm.com\/zh\/the-effect-of-proto-type-wearable-light-emitting-devices-on-serum-25-hydroxyvitamin-d-levels-in-healthy-adults-a-4-week-randomized-controlled-trial\/","title":{"rendered":"\u539f\u578b\u53ef\u7a7f\u6234\u53d1\u5149\u8bbe\u5907\u5bf9\u5065\u5eb7\u6210\u4eba\u8840\u6e05 25-\u7f9f\u57fa\u7ef4\u751f\u7d20 D \u6c34\u5e73\u7684\u5f71\u54cd\uff1a\u4e00\u9879\u4e3a\u671f 4 \u5468\u7684\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c"},"content":{"rendered":"<div id=\"Sec2-content\">\n<h3 id=\"Sec3\" class=\"c-article__sub-heading\">\u7814\u7a76\u4eba\u7fa4<\/h3>\n<p>\u672c\u7814\u7a76\u5728\u97e9\u56fd\u57ce\u5357\u5e02\u9996\u5c14\u56fd\u7acb\u5927\u5b66\u76c6\u5510\u533b\u9662 (SNUBH) \u7684\u7761\u7720\u8bca\u6240\u8fdb\u884c\u30022020 \u5e74 8 \u6708\u81f3 2021 \u5e74 8 \u6708\u671f\u95f4\uff0c\u901a\u8fc7\u5f53\u5730\u793e\u533a\u7684\u5e7f\u544a\u62db\u52df\u4e86 20-65 \u5c81\u7684\u5065\u5eb7\u6210\u5e74\u4eba\u3002\u5165\u9009\u7684\u53c2\u4e0e\u8005\u5728\u7b2c\u4e00\u6b21\u5c31\u8bca\u65f6\u63a5\u53d7\u4e86\u7b5b\u67e5\u6d4b\u8bd5\uff0c\u5373\u5728\u5e72\u9884\u5f00\u59cb\u524d\u4e00\u5468\u5185\u3002\u5728\u7b5b\u67e5\u6d4b\u8bd5\u4e2d\u51fa\u73b0\u4e0d\u826f\u76ae\u80a4\u53cd\u5e94\u7684\u4eba\u88ab\u6392\u9664\u5728\u5916\u3002\u6211\u4eec\u8fd8\u6392\u9664\u4e86\u7b26\u5408\u4ee5\u4e0b\u6807\u51c6\u7684\u4eba\uff1a(1) \u5728\u7814\u7a76\u5f00\u59cb\u524d\u4e24\u4e2a\u6708\u5185\u6709\u8fc7\u5149\u7597\u6216\u7ef4\u751f\u7d20 D \u8865\u5145\u53f2\uff1b(2) \u76ae\u80a4\u75c5\uff0c\u5305\u62ec\u76ae\u80a4\u764c\u548c\u5149\u654f\u6027\uff1b(3) \u6076\u6027\u80bf\u7624\u3001\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u3001\u4f20\u67d3\u75c5\u3001\u809d\u80be\u529f\u80fd\u4e0d\u5168\u548c\u5934\u90e8\u521b\u4f24\u7b49\u75be\u75c5\uff1b(4) \u7cbe\u795e\u75be\u75c5\uff0c\u5305\u62ec\u60c5\u7eea\u969c\u788d\u3001\u7126\u8651\u75c7\u3001\u7761\u7720\u969c\u788d\u548c\u7cbe\u795e\u75c5\u3002\u5728\u7814\u7a76\u5f00\u59cb\u524d\uff0c\u5df2\u83b7\u5f97\u6240\u6709\u53c2\u4e0e\u8005\u7684\u4e66\u9762\u77e5\u60c5\u540c\u610f\u3002\u672c\u7814\u7a76\u5df2\u83b7\u5f97 SNUBH \u673a\u6784\u5ba1\u67e5\u59d4\u5458\u4f1a (B-2002-597-003) \u7684\u6279\u51c6\uff0c\u5e76\u5728\u97e9\u56fd\u4e34\u5e8a\u7814\u7a76\u4fe1\u606f\u670d\u52a1 (CRIS) \u6ce8\u518c (\u6ce8\u518c\u53f7 KCT0007033)\u3002<\/p>\n<h3 id=\"Sec4\" class=\"c-article__sub-heading c-article__sub-heading--divider\">\u5e72\u6d89<\/h3>\n<p>\u6211\u4eec\u4f7f\u7528\u4e86\u4e24\u79cd\u4e0d\u540c\u7c7b\u578b\u7684\u539f\u578b\u53ef\u7a7f\u6234\u53d1\u5149\u88c5\u7f6e\uff08\u6709\u6e90\u88c5\u7f6e\u548c\u5047\u88c5\u7f6e\uff09\uff0c\u5b83\u4eec\u90fd\u662f\u7531\u97e9\u56fd\u5927\u7530\u97e9\u56fd\u79d1\u5b66\u6280\u672f\u9662\u7535\u6c14\u5de5\u7a0b\u5b66\u9662\u5b9a\u5236\u8bbe\u8ba1\u7684\u3002\u6709\u6e90\u88c5\u7f6e\u7531 48 \u4e2a LED\uff08QD Jason\uff0c\u4e2d\u56fd\uff0c\u578b\u53f7 J35ABA285P09A\uff09\u7ec4\u6210\uff0c\u5b83\u4eec\u53d1\u5c04\u5cf0\u503c\u6ce2\u957f\u4e3a 285 nm \u7684 UVB \u5149\uff0c\u534a\u5cf0\u5168\u5bbd\u4e3a 11 nm\u3002LED \u4ee5 6\u00d78 \u77e9\u9635\u5f62\u5f0f\u6392\u5217\u5728\u67d4\u6027\u5370\u5237\u7535\u8def\u677f (FPCB) \u4e0a\uff0c\u76f8\u90bb LED \u4e4b\u95f4\u7684\u95f4\u9694\u4e3a 13 mm\u3002\u7136\u540e\uff0c\u5c06\u5e26\u6709\u8fd9 48 \u4e2a UVB LED \u7684 FPCB \u653e\u7f6e\u5728 3D \u6253\u5370\u5916\u58f3\u4e2d\uff0c\u8be5\u5916\u58f3\u53ef\u4ee5\u7f20\u7ed5\u5728\u4e0b\u81c2\u6216\u4e0a\u81c2\u4e0a\u3002LED \u4e0e\u7167\u660e\u4e0b\u7684\u76ae\u80a4\u8868\u9762\u4e4b\u95f4\u7684\u8ddd\u79bb\u4fdd\u6301\u5728\u7ea6 5 mm\uff0c\u4ee5\u786e\u4fdd LED \u53d1\u51fa\u7684\u5149\u7ebf\u53ef\u4ee5\u6269\u6563\u5230\u76ae\u80a4\u4e0a\u3002\u6b64\u5916\uff0cLED \u548c\u76ae\u80a4\u8868\u9762\u4e4b\u95f4\u653e\u7f6e\u4e86\u900f\u660e\u7684\u805a\u4e8c\u7532\u57fa\u7845\u6c27\u70f7 (PDMS) \u5f39\u6027\u4f53\uff0c\u4ee5\u786e\u4fdd\u76ae\u80a4\u4e0e LED \u4e4b\u95f4\u7684\u8ddd\u79bb\u4fdd\u6301\u4e0d\u53d8\u3002PDMS \u5c42\u7684\u4e00\u4fa7\u91c7\u7528\u5fae\u7ed3\u6784\uff0c\u4ee5\u8fdb\u4e00\u6b65\u589e\u5f3a LED \u5149\u7684\u6269\u6563\u3002\u6574\u4f53\u7167\u660e\u9762\u79ef\u7ea6\u4e3a 80 \u5398\u7c73<sup>2<\/sup>\u5149\u6269\u6563\u7ed3\u6784\u53ef\u627f\u53d7\u7ea6 7.8 mJ\/cm2 \u7684\u5242\u91cf<sup>2<\/sup> \u6bcf\u5206\u949f\u66dd\u5149\u4e00\u6b21\u3002\u5047\u88c5\u7f6e\u5177\u6709\u76f8\u540c\u7684\u7ed3\u6784\uff0c\u53ea\u662f LED \u53d1\u51fa\u7684\u662f\u5cf0\u503c\u6ce2\u957f\u4e3a 465 nm \u7684\u84dd\u5149\uff0c\u800c\u4e0d\u662f UVB \u5149\uff08\u56fe\uff09\u3002 <a href=\"http:\/\/www.nature.com\/articles\/s41430-022-01241-z#Fig1\" data-track=\"click\" data-track-label=\"link\" data-track-action=\"figure anchor\">1<\/a>).<\/p>\n<div id=\"figure-1\" class=\"c-article-section__figure js-c-reading-companion-figures-item\" data-test=\"figure\" data-container-section=\"figure\" data-title=\"Photographs of the proto-type wearable devices.\">\n<figure><figcaption><b id=\"Fig1\" class=\"c-article-section__figure-caption\" data-test=\"figure-caption-text\">\u56fe 1\uff1a\u539f\u578b\u53ef\u7a7f\u6234\u8bbe\u5907\u7684\u7167\u7247\u3002<\/b><\/figcaption><div class=\"c-article-section__figure-content\">\n<div class=\"c-article-section__figure-item\"><a class=\"c-article-section__figure-link\" href=\"https:\/\/www.nature.com\/articles\/s41430-022-01241-z\/figures\/1\" rel=\"nofollow\" data-test=\"img-link\" data-track=\"click\" data-track-label=\"image\" data-track-action=\"view figure\"><picture><source srcset=\"https:\/\/media.springernature.com\/lw685\/springer-static\/image\/art%3A10.1038%2Fs41430-022-01241-z\/MediaObjects\/41430_2022_1241_Fig1_HTML.png?as=webp\" type=\"image\/webp\" \/><img fetchpriority=\"high\" decoding=\"async\" src=\"https:\/\/media.springernature.com\/lw685\/springer-static\/image\/art%3A10.1038%2Fs41430-022-01241-z\/MediaObjects\/41430_2022_1241_Fig1_HTML.png\" alt=\"figure 1\" width=\"685\" height=\"284\" aria-describedby=\"Fig1\" \/><\/picture><\/a><\/div>\n<div id=\"figure-1-desc\" class=\"c-article-section__figure-description\" data-test=\"bottom-caption\">\n<p><b>A<\/b> \u62df\u8bae\u7684\u7d2b\u5916\u7ebf B \u53ef\u7a7f\u6234\u8bbe\u5907\u5e26\u6709\u5b9a\u5236\u63a7\u5236\u5668\u7684\u7167\u7247\u3002 <b>\u4e59<\/b> \u4f69\u6234\u5728\u524d\u81c2\u4e0a\u7684\u7d2b\u5916\u7ebfB\u53ef\u7a7f\u6234\u8bbe\u5907\u7684\u7167\u7247\u3002<\/p>\n<\/div>\n<\/div>\n<\/figure>\n<\/div>\n<p>\u7b2c\u4e00\u6b21\u8bbf\u95ee\u65f6\uff0c\u4f7f\u7528\u7531\u5355\u4e2a LED \u5236\u6210\u7684\u6d4b\u8bd5\u88c5\u7f6e\u8fdb\u884c\u7b5b\u9009\u6d4b\u8bd5\uff0c\u8be5\u88c5\u7f6e\u53d1\u5c04\u4e0e\u6709\u6e90\u88c5\u7f6e\u76f8\u540c\u6ce2\u957f\u548c\u5f3a\u5ea6\u7684 UVB \u5149\uff0c\u7167\u5c04\u5230 3 \u5398\u7c73\u7684\u5e73\u9762\u4e0a\u3002<sup>2<\/sup> \u524d\u81c2\u76ae\u80a4\u533a\u57df\u3002\u6b64\u540e\uff0c\u7b26\u5408\u6761\u4ef6\u7684\u53c2\u4e0e\u8005\u4ee5 1:1 \u7684\u6bd4\u4f8b\u968f\u673a\u5206\u914d\u5230\u5b9e\u9a8c\u7ec4\u6216\u5bf9\u7167\u7ec4\uff0c\u5e76\u5bf9\u5e72\u9884\u5206\u914d\u4e0d\u77e5\u60c5\u3002\u968f\u673a\u5206\u914d\u7531\u7b2c\u4e09\u65b9\u901a\u8fc7\u5206\u5c42\u7f6e\u6362\u533a\u7ec4\u968f\u673a\u5316\u65b9\u6cd5\u8fdb\u884c\u3002\u5728\u7b2c\u4e00\u6b21\u8bbf\u95ee\u540e\u4e00\u5468\u5185\u7684\u7b2c\u4e8c\u6b21\u8bbf\u95ee\u4e2d\uff0c\u53c2\u4e0e\u8005\u6839\u636e\u4ed6\u4eec\u7684\u968f\u673a\u5206\u7ec4\u5206\u914d\u63a5\u53d7\u4e3b\u52a8\u6216\u5047\u8bbe\u5907\u3002\u4ed6\u4eec\u88ab\u8981\u6c42\u4f69\u6234\u8be5\u8bbe\u5907\u603b\u5171 2 \u5206\u949f\uff0c\u6bcf\u5929\u6bcf\u53ea\u524d\u81c2\u4f69\u6234 1 \u5206\u949f\uff0c\u6301\u7eed 4 \u5468\u3002\u6bcf\u53ea\u624b\u81c2\u4e0a\u4e00\u5206\u949f\u7684\u7d2b\u5916\u7ebf\u7167\u5c04\u7531\u8bbe\u5907\u7684\u63a7\u5236\u5668\u5355\u5143\u63a7\u5236\u3002\u56e0\u6b64\uff0c\u6709\u6e90\u88c5\u7f6e\u6bcf\u5355\u4f4d\u9762\u79ef UVB \u8f90\u5c04\u7684\u6bcf\u65e5\u5242\u91cf\u786e\u5b9a\u4e3a\u5927\u7ea6 7.8 mJ\/cm2<sup>2<\/sup>\uff0c\u6709\u6548\u66dd\u5149\u9762\u79ef\u7ea6\u4e3a80 cm<sup>2<\/sup> \u6bcf\u53ea\u524d\u81c2\u7684\u65e5\u603b\u5242\u91cf\u4e3a 1.25 J (=7.8 mJ\/cm<sup>2<\/sup> \u00d7 80 \u5398\u7c73<sup>2<\/sup>\u00d7 2\uff09\u3002\u4e3a\u4e86\u53d7\u8bd5\u8005\u7684\u5b89\u5168\uff0c\u6211\u4eec\u5728\u7b2c\u4e09\u6b21\u548c\u7b2c\u56db\u6b21\u8bbf\u89c6\uff08\u5206\u522b\u5728\u5e72\u9884\u5f00\u59cb\u540e 2 \u5468\u548c 4 \u5468\uff09\u76d1\u6d4b\u4efb\u4f55\u4e0d\u826f\u4e8b\u4ef6\u7684\u53d1\u751f\u60c5\u51b5\u548c\u8bbe\u5907\u4f7f\u7528\u4f9d\u4ece\u6027\u3002\u5982\u679c\u5e72\u9884\u540e\u51fa\u73b0\u4efb\u4f55\u53ef\u7591\u7684\u4e0d\u826f\u76ae\u80a4\u53cd\u5e94\uff0c\u5305\u62ec\u7ea2\u6591\u6216\u76ae\u75b9\uff0c\u5219\u7acb\u5373\u505c\u6b62\u4f7f\u7528\u8be5\u8bbe\u5907\uff0c\u5e76\u4e14\u53d7\u8bd5\u8005\u9000\u51fa\u8bd5\u9a8c\u3002<\/p>\n<h3 id=\"Sec5\" class=\"c-article__sub-heading c-article__sub-heading--divider\">\u8840\u6e0525-\u7f9f\u57fa\u7ef4\u751f\u7d20D\u6d4b\u5b9a<\/h3>\n<p>\u6211\u4eec\u91c7\u7528\u8840\u6e05 25-\u7f9f\u57fa\u7ef4\u751f\u7d20 D [25(OH)D] \u6d53\u5ea6\u4f5c\u4e3a\u8840\u6e05\u7ef4\u751f\u7d20 D \u8425\u517b\u72b6\u51b5\u7684\u6307\u6807\uff0c\u56e0\u4e3a\u5b83\u88ab\u5e7f\u6cdb\u7528\u4e8e\u6d4b\u91cf\u8840\u6e05\u7ef4\u751f\u7d20 D \u8425\u517b\u72b6\u51b5[<a id=\"ref-link-section-d591248957e790\" title=\"Cashman KD\u3001van den Heuvel EG\u3001Schoemaker RJ\u3001Pr\u00e9v\u00e9raud DP\u3001Macdonald HM\u3001Arcot J\u300225-\u7f9f\u57fa\u7ef4\u751f\u7d20 D \u4f5c\u4e3a\u7ef4\u751f\u7d20 D \u72b6\u6001\u7684\u751f\u7269\u6807\u5fd7\u7269\u53ca\u5176\u5efa\u6a21\uff0c\u4e3a\u9884\u9632\u4eba\u7fa4\u4e2d\u7ef4\u751f\u7d20 D \u7f3a\u4e4f\u7684\u7b56\u7565\u63d0\u4f9b\u4fe1\u606f\u3002\u9ad8\u7ea7\u8425\u517b\u3002 2017\uff1b8\uff1a947\u201357\u3002\" href=\"http:\/\/www.nature.com\/articles\/s41430-022-01241-z#ref-CR17\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"\u53c2\u8003\u6587\u732e 17\">17<\/a>]\u3002\u91c7\u7528\u9ad8\u6548\u6db2\u76f8\u8272\u8c31\u4e32\u8054\u8d28\u8c31\u6cd5\u6d4b\u91cf\u8840\u6e0525(OH)D\u6d53\u5ea6\u3002\u7ef4\u751f\u7d20D\u901a\u8fc7\u809d\u810f\u548c\u80be\u810f\u4ee3\u8c22\uff0c\u5176\u4ee3\u8c22\u4e0e\u8840\u6e05\u9499\u548c\u78f7\u9178\u76d0\u6709\u5173[<a id=\"ref-link-section-d591248957e793\" title=\"Bikle DD\u3002\u7ef4\u751f\u7d20 D \u4ee3\u8c22\u3001\u4f5c\u7528\u673a\u5236\u548c\u4e34\u5e8a\u5e94\u7528\u3002Chem Biol. 2014\uff1b21\uff1a319-29\u3002\" href=\"http:\/\/www.nature.com\/articles\/s41430-022-01241-z#ref-CR18\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"\u53c2\u8003\u6587\u732e18\">18<\/a>]\u3002\u56e0\u6b64\uff0c\u5728\u6d4b\u91cf\u8840\u6e05 25(OH)D \u7684\u540c\u65f6\uff0c\u8fd8\u8bc4\u4f30\u4e86\u8840\u6e05\u9499\u3001\u78f7\u9178\u76d0\u3001\u4e19\u6c28\u9178\u8f6c\u6c28\u9176\u3001\u5929\u51ac\u6c28\u9178\u8f6c\u6c28\u9176\u3001\u78b1\u6027\u78f7\u9178\u9176\u3001\u03b3-\u8c37\u6c28\u9170\u8f6c\u80bd\u9176\u3001\u603b\u80c6\u7ea2\u7d20\u3001\u808c\u9150\u548c\u8840\u5c3f\u7d20\u6c2e\u7684\u6c34\u5e73\u3002\u5728\u7b2c\u4e00\u6b21\uff08\u57fa\u7ebf\uff09\u3001\u7b2c\u4e09\u6b21\uff08\u7b2c 2 \u5468\uff09\u3001\u7b2c\u56db\u6b21\uff08\u7b2c 4 \u5468\uff09\u548c\u6700\u540e\u4e00\u6b21\u8bbf\u89c6\u65f6\u8fdb\u884c\u4e86\u56db\u6b21\u8840\u6db2\u6d4b\u8bd5\u3002\u6700\u540e\u4e00\u6b21\u8bbf\u89c6\u662f\u5728\u5e72\u9884\u7ed3\u675f\u4e24\u5468\u540e\uff08\u7b2c 6 \u5468\uff09\u8fdb\u884c\u7684\u3002\u6240\u6709\u8840\u6db2\u6837\u672c\u5747\u5728\u767d\u5929\uff08\u4e0a\u5348 9:30 \u81f3\u4e0b\u5348 4:00\uff09\u975e\u7a7a\u8179\u72b6\u6001\u4e0b\u91c7\u96c6\uff0c\u5e76\u7ecf\u8fc7\u9002\u5f53\u5904\u7406\u540e\u8fd0\u9001\u5230\u68c0\u6d4b\u673a\u6784\uff08\u9996\u5c14\u4e34\u5e8a\u5b9e\u9a8c\u5ba4\uff0c\u97e9\u56fd\u9996\u5c14\uff09\u3002\u6bcf\u4f4d\u53c2\u4e0e\u8005\u7684\u6240\u6709\u8840\u6db2\u6d4b\u8bd5\u90fd\u5728\u4e00\u5929\u4e2d\u7684\u540c\u4e00\u65f6\u95f4\u8fdb\u884c\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u97e9\u56fd\u6210\u5e74\u4eba\u53e3\u8840\u6e05 25(OH)D \u6c34\u5e73\u7684\u5b63\u8282\u6027\u53d8\u5316\uff0c\u53c2\u4e0e\u8005\u53c2\u52a0\u7814\u7a76\u7684\u5b63\u8282\u88ab\u89c6\u4e3a\u6df7\u6742\u56e0\u7d20[<a id=\"ref-link-section-d591248957e796\" title=\"Nah EH\uff0cKim S\uff0cCho HI\u3002\u97e9\u56fd\u4eba\u7684\u7ef4\u751f\u7d20 D \u6c34\u5e73\u548c\u7ef4\u751f\u7d20 D \u7f3a\u4e4f\u75c7\u60a3\u75c5\u7387\u4e0e\u6027\u522b\u3001\u5e74\u9f84\u3001\u5730\u533a\u548c\u5b63\u8282\u76f8\u5173\u3002\u5b9e\u9a8c\u5ba4\u533b\u5b66\u5728\u7ebf\u3002 2015\uff1b5\uff1a84\u201391\u3002\" href=\"http:\/\/www.nature.com\/articles\/s41430-022-01241-z#ref-CR19\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"\u53c2\u8003\u6587\u732e19\">19<\/a>]\uff0c\u6839\u636e\u7814\u7a76\u5165\u5b66\u5b63\u8282\uff0c\u6211\u4eec\u5c06\u7814\u7a76\u5bf9\u8c61\u5206\u4e3a\u56db\u7ec4\uff1a\u6625\u5b63\uff083\u6708\u81f35\u6708\uff09\u3001\u590f\u5b63\uff086\u6708\u81f38\u6708\uff09\u3001\u79cb\u5b63\uff089\u6708\u81f311\u6708\uff09\u548c\u51ac\u5b63\uff0812\u6708\u81f32\u6708\uff09\u3002<\/p>\n<h3 id=\"Sec6\" class=\"c-article__sub-heading c-article__sub-heading--divider\">\u4eba\u53e3\u7279\u5f81<\/h3>\n<p>\u9996\u6b21\u5c31\u8bca\u65f6\u83b7\u5f97\u4e86\u4eba\u53e3\u7edf\u8ba1\u4fe1\u606f\uff0c\u5305\u62ec\u5e74\u9f84\u3001\u6027\u522b\u3001\u4f53\u91cd\u6307\u6570\u3001\u5a5a\u59fb\u72b6\u51b5\u3001\u6559\u80b2\u6c34\u5e73\u3001\u5f53\u524d\u5438\u70df\u72b6\u51b5\u3001\u996e\u9152\u4e60\u60ef\u548c\u4f53\u529b\u6d3b\u52a8\u6c34\u5e73\u3002\u81f3\u4e8e\u996e\u9152\u4e60\u60ef\uff0c\u5982\u679c\u53c2\u4e0e\u8005\u5728\u8fc7\u53bb\u4e00\u4e2a\u6708\u81f3\u5c11\u996e\u9152\u4e00\u6b21\uff0c\u5219\u88ab\u5206\u7ec4\u4e3a\u9633\u6027\u3002\u5728\u4f53\u529b\u6d3b\u52a8\u6c34\u5e73\u65b9\u9762\uff0c\u6bcf\u5468\u8fdb\u884c3\u6b21\u3001\u6bcf\u6b21\u81f3\u5c1130\u5206\u949f\u7684\u4efb\u4f55\u8fd0\u52a8\u7684\u4eba\u88ab\u5f52\u7c7b\u4e3a\u9633\u6027\u3002<\/p>\n<h3 id=\"Sec7\" class=\"c-article__sub-heading c-article__sub-heading--divider\">\u8425\u517b\u548c\u6237\u5916\u6d3b\u52a8<\/h3>\n<p>\u8840\u6e05 25(OH)D \u6c34\u5e73\u53ef\u80fd\u4f1a\u53d7\u5230\u76ae\u80a4\u901a\u8fc7\u9633\u5149\u7167\u5c04\u6216\u81b3\u98df\u8865\u5145\u5242\u4ea7\u751f\u7684\u7ef4\u751f\u7d20 D \u7684\u5f71\u54cd\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u68c0\u67e5\u4e86\u5e72\u9884\u540e 2 \u5468\u548c 4 \u5468\u4ee5\u53ca\u5e72\u9884\u7ed3\u675f\u540e 2 \u5468\u65f6\u6bcf\u65e5\u81b3\u98df\u7ef4\u751f\u7d20 D \u6444\u5165\u91cf\u548c\u6237\u5916\u6d3b\u52a8\u65f6\u95f4\u3002\u6240\u6709\u53c2\u4e0e\u8005\u90fd\u88ab\u8981\u6c42\u5728\u5e72\u9884\u671f\u95f4\u7684\u6574\u4e2a 4 \u5468\u4ee5\u53ca\u5e72\u9884\u7ed3\u675f\u540e\u7684\u53e6\u5916 2 \u5468\u5185\u6bcf\u5929\u8bb0\u5f55\u996e\u98df\u548c\u6237\u5916\u6d3b\u52a8\u6c34\u5e73\u3002\u6211\u4eec\u8fd8\u8ba1\u7b97\u4e86\u4ece\u5e72\u9884\u5f00\u59cb\u5230\u6bcf\u6b21\u8bc4\u4f30\u7684\u5e73\u5747\u6bcf\u65e5\u81b3\u98df\u7ef4\u751f\u7d20 D \u6444\u5165\u91cf\u548c\u6237\u5916\u6d3b\u52a8\u65f6\u95f4\u3002<\/p>\n<h3 id=\"Sec8\" class=\"c-article__sub-heading c-article__sub-heading--divider\">\u7edf\u8ba1\u5206\u6790<\/h3>\n<p>\u6211\u4eec\u4f7f\u7528 G*Power \u8f6f\u4ef6\u8ba1\u7b97\u51fa\u6240\u9700\u7684\u6700\u5c0f\u6837\u672c\u91cf\u4e3a 128 \u540d\u53d7\u8bd5\u8005\uff08\u6bcf\u7ec4 64 \u540d\uff09\uff0c\u7f6e\u4fe1\u5ea6\u4e3a 95%\uff0c\u6548\u5e94\u91cf\u4e3a 0.5\uff0c\u7edf\u8ba1\u529f\u6548\u4e3a 0.8\u3002\u91c7\u7528\u6548\u5e94\u91cf 0.5 \u662f\u56e0\u4e3a\u5b83\u4ee3\u8868\u201c\u4e2d\u7b49\u201d\u6548\u5e94\u91cf\u3002\u8003\u8651\u5230 15% \u7684\u9000\u51fa\u7387\uff0c\u6211\u4eec\u51b3\u5b9a\u62db\u52df\u4e0d\u5c11\u4e8e 150 \u540d\u53d7\u8bd5\u8005\uff08\u6bcf\u7ec4 75 \u540d\uff09\u3002\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u5728\u6392\u9664\u9000\u51fa\u8005\u7684\u6570\u636e\u540e\u8fdb\u884c\u4e86\u7b26\u5408\u65b9\u6848 (PP) \u5206\u6790\u3002<\/p>\n<p>\u4f7f\u7528\u72ec\u7acb t \u68c0\u9a8c\u6216 Mann Whitney U \u68c0\u9a8c\u5bf9\u8fde\u7eed\u53d8\u91cf\u8fdb\u884c\u6bd4\u8f83\uff0c\u5e76\u4f7f\u7528\u5361\u65b9\u68c0\u9a8c\u5bf9\u5b9e\u9a8c\u7ec4\u548c\u5bf9\u7167\u7ec4\u4e4b\u95f4\u7684\u5206\u7c7b\u53d8\u91cf\u8fdb\u884c\u6bd4\u8f83\u3002\u5173\u4e8e\u6bcf\u6b21\u8840\u6e05 25(OH)D \u6c34\u5e73\u8bc4\u4f30\u4e2d\u76f8\u5bf9\u4e8e\u57fa\u7ebf\u7684\u53d8\u5316\uff0c\u914d\u5bf9 t \u68c0\u9a8c\u548c\u72ec\u7acb t \u68c0\u9a8c\uff08\u6216 Mann Whitney <i>U<\/i> \u91c7\u7528\u68c0\u9a8c\uff09\u5206\u522b\u8bc4\u4ef7\u7ec4\u5185\u5dee\u5f02\u548c\u7ec4\u95f4\u5dee\u5f02\u3002\u8fd8\u8fdb\u884c\u4e86\u534f\u65b9\u5dee\u5206\u6790\uff0c\u4ee5\u6bd4\u8f83\u63a7\u5236\u53ef\u80fd\u7684\u6df7\u6742\u56e0\u7d20\u540e\u8840\u6e05 25(OH)D \u6c34\u5e73\u7684\u53d8\u5316\u3002\u4f5c\u4e3a\u5b9e\u9a8c\u7ec4\u7684\u4e9a\u5206\u6790\uff0c\u6211\u4eec\u4f7f\u7528\u72ec\u7acbt\u68c0\u9a8c\u548cANCOVA\u6765\u6bd4\u8f83\u57fa\u7ebf\u8bc4\u4f30\u65f6\u6709\u548c\u6ca1\u6709\u7ef4\u751f\u7d20D\u7f3a\u4e4f\u8005\u5728\u5e72\u98844\u5468\u540e\u8840\u6e0525(OH)D\u6c34\u5e73\u7684\u53d8\u5316\u3002\u7ef4\u751f\u7d20 D \u7f3a\u4e4f\u75c7\u5b9a\u4e49\u4e3a\u8840\u6e05 25(OH)D \u6c34\u5e73&lt;20 ng\/ml [<a id=\"ref-link-section-d591248957e830\" title=\"\u666e\u798f\u6ed5\u8c6a\u5c14 KM\uff0c\u8212\u5e03\u9c81\u514b JH\u3002\u7ef4\u751f\u7d20 D \u7f3a\u4e4f\u75c7\u3001\u5176\u5728\u5065\u5eb7\u548c\u75be\u75c5\u4e2d\u7684\u4f5c\u7528\u4ee5\u53ca\u5f53\u524d\u7684\u8865\u5145\u5efa\u8bae\u3002 J Am \u6574\u9aa8\u7597\u6cd5\u534f\u4f1a\u3002 2017\uff1b117\uff1a301\u20135\u3002\" href=\"http:\/\/www.nature.com\/articles\/s41430-022-01241-z#ref-CR20\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"\u53c2\u8003\u6587\u732e 20\">20<\/a>]\u3002\u6240\u6709\u7edf\u8ba1\u5206\u6790\u5747\u4f7f\u7528 Windows \u7248 SPSS 25.0 \u7248\uff08SPSS\uff0c\u829d\u52a0\u54e5\uff0c\u4f0a\u5229\u8bfa\u4f0a\u5dde\uff0c\u7f8e\u56fd\uff09\u548c\u53cc\u5c3e <i>p<\/i> \u5c0f\u4e8e0.05\u7684\u503c\u88ab\u8ba4\u4e3a\u5177\u6709\u7edf\u8ba1\u663e\u7740\u6027\u3002<\/p>\n<\/div>\n<p>[\u5e7f\u544a_2]<\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41430-022-01241-z\">\u6765\u6e90\u94fe\u63a5 <\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>At the first visit, a screening test was conducted using a testing device made of a single LED, which emitted UVB light with the same wavelength and intensity as the active device, onto a 3-cm2 area of forearm skin.<\/p>","protected":false},"author":1,"featured_media":5359,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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