{"id":5081,"date":"2024-01-15T12:21:35","date_gmt":"2024-01-15T12:21:35","guid":{"rendered":"https:\/\/www.farlong.com\/?p=5081"},"modified":"2024-01-27T10:42:32","modified_gmt":"2024-01-27T10:42:32","slug":"therapeutic-effects-of-breviscapine-in-cardiovascular-diseases-a-review","status":"publish","type":"post","link":"https:\/\/directcm.com\/zh\/therapeutic-effects-of-breviscapine-in-cardiovascular-diseases-a-review\/","title":{"rendered":"\u706f\u76cf\u82b1\u7d20\u5bf9\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u6cbb\u7597\u4f5c\u7528\uff1a\u7efc\u8ff0"},"content":{"rendered":"<div id=\"abstract-a.k.b.n\" class=\"tsec sec\" lang=\"en\">\n<div id=\"abstract-a.k.b.n\" class=\"tsec sec\" lang=\"en\">\n<div>\n<div class=\"fm-sec half_rhythm no_top_margin\">\n<div class=\"half_rhythm\"><\/div>\n<\/div>\n<div class=\"sec\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" style=\"font-size: 16px; background-color: #ffffff;\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"menuitem\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<div id=\"abstract-a.k.b.n\" class=\"tsec sec\" lang=\"en\">\n<h2 id=\"abstract-a.k.b.ntitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u62bd\u8c61\u7684<\/h2>\n<div>\n<p class=\"p p-first-last\"><span style=\"font-size: 16px;\">\u706f\u76cf\u82b1\u7d20\u662f\u591a\u79cd\u9ec4\u916e\u7c7b\u5316\u5408\u7269\u7684\u7c97\u63d0\u7269 <\/span><em style=\"font-size: 16px;\">\u706f\u76cf\u82b1 (Vant.) Hand.-Mazz.<\/em><span style=\"font-size: 16px;\">\uff0c\u542b\u670985%\u4ee5\u4e0a\u7684\u706f\u76cf\u82b1\u4e59\u7d20\uff0c\u5728\u6211\u56fd\u4f20\u7edf\u4e0a\u7528\u4f5c\u6d3b\u8840\u836f\uff0c\u6539\u5584\u8111\u4f9b\u8840\u3002\u6536\u96c6\u5404\u79cd\u8bc1\u636e\u00a0<\/span><em style=\"font-size: 16px;\">\u4f53\u5185<\/em><span style=\"font-size: 16px;\">\u00a0\u548c\u00a0<\/span><em style=\"font-size: 16px;\">\u4f53\u5916<\/em><span style=\"font-size: 16px;\">\u00a0\u7814\u7a76\u8868\u660e\u706f\u76cf\u82b1\u7d20\u5177\u6709\u5e7f\u6cdb\u7684\u5fc3\u8840\u7ba1\u836f\u7406\u4f5c\u7528\uff0c\u5305\u62ec\u8840\u7ba1\u8212\u5f20\u3001\u9632\u6b62\u7f3a\u8840\/\u518d\u704c\u6ce8\uff08I\/R\uff09\u3001\u6297\u708e\u3001\u6297\u51dd\u3001\u6297\u8840\u6813\u5f62\u6210\u3001\u5185\u76ae\u4fdd\u62a4\u3001\u5fc3\u808c\u4fdd\u62a4\u3001\u51cf\u5c11\u5e73\u6ed1\u808c\u7ec6\u80de\u8fc1\u79fb\u548c\u589e\u6b96\u3001\u6297\u5fc3\u810f\u91cd\u6784\u3001\u6297\u5fc3\u5f8b\u5931\u5e38\u3001\u964d\u8840\u8102\u3001\u6539\u5584\u52c3\u8d77\u529f\u80fd\u969c\u788d\u3002\u6b64\u5916\uff0c\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u62a5\u9053\uff0c\u706f\u76cf\u82b1\u7d20\u53ef\u4e0e\u897f\u836f\u8054\u5408\u7528\u4e8e\u6cbb\u7597\u51a0\u5fc3\u75c5\u3001\u5fc3\u808c\u6897\u585e\u3001\u9ad8\u8840\u538b\u3001\u5fc3\u623f\u98a4\u52a8\u3001\u9ad8\u8102\u8840\u75c7\u3001\u75c5\u6bd2\u6027\u5fc3\u808c\u708e\u3001\u6162\u6027\u5fc3\u529b\u8870\u7aed\u3001\u80ba\u5fc3\u75c5\u7b49\u5fc3\u8840\u7ba1\u75be\u75c5\u3002 \u3002\u7136\u800c\uff0c\u57fa\u4e8e\u5b9e\u9a8c\u7814\u7a76\u7684\u706f\u76cf\u82b1\u7d20\u5bf9\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u4fdd\u62a4\u4f5c\u7528\u53ca\u5176\u6f5c\u5728\u673a\u5236\u5c1a\u672a\u5f97\u5230\u7cfb\u7edf\u8bc4\u4ef7\u3002\u672c\u6587\u7efc\u8ff0\u4e86\u706f\u76cf\u82b1\u7d20\u5fc3\u810f\u4fdd\u62a4\u4f5c\u7528\u7684\u836f\u7406\u5b66\u673a\u5236\uff0c\u5e76\u9610\u660e\u4e86\u5176\u4e34\u5e8a\u5e94\u7528\u3002<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"sec\"><strong class=\"kwd-title\">\u5173\u952e\u8bcd\uff1a\u00a0<\/strong><span class=\"kwd-text\">\u706f\u76cf\u82b1\u7d20\u3001\u4e2d\u836f\u3001\u6c11\u65cf\u836f\u7406\u5b66\u3001\u8349\u836f\u3001\u8349\u836f\u6d3b\u6027\u5316\u5408\u7269<\/span><\/div>\n<div><\/div>\n<\/div>\n<div id=\"sec-a.l.a\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"sec-a.l.atitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u4ecb\u7ecd<\/h2>\n<p>&nbsp;<\/p>\n<p class=\"p p-first\"><em>\u706f\u76cf\u82b1<\/em>\u00a0(<em>\u706f\u76cf\u82b1 (Vant.) Hand.-Mazz.<\/em>\uff09\uff0c\u4e5f\u79f0\u4e3a\u00a0<em>\u706f\u76cf\u7ec6\u8f9b<\/em>\u00a0\u6216\u8005\u00a0<em>\u706f\u83ca<\/em>\u662f\u4e00\u79cd\u4f20\u7edf\u4e2d\u836f\u6750\uff0c\u5df2\u6709600\u591a\u5e74\u7684\u4f7f\u7528\u5386\u53f2\uff0c\u4ea7\u4e8e\u4e91\u5357\u3001\u56db\u5ddd\u3001\u8d35\u5dde\u7b49\u4e2d\u56fd\u897f\u5357\u7701\u4efd\u3002\u5b83\u5c5e\u4e8e\u96cf\u83ca\u79d1\uff0c\u662f\u4e00\u79cd\u591a\u5e74\u751f\u4e1b\u751f\u8349\u672c\u690d\u7269\uff0c\u53ef\u4ee5\u957f\u5230 50 \u5398\u7c73\uff0820 \u82f1\u5bf8\uff09\u9ad8\uff0c\u4f46\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u53ef\u4ee5\u957f\u5230\u4e0d\u5230 1 \u5398\u7c73\uff080.4 \u82f1\u5bf8\uff09\u9ad8\u3002\u6b64\u5916\uff0c\u5b83\u7684\u5934\u72b6\u82b1\u5e8f\u6709\u84dd\u8272\u3001\u7d2b\u8272\u6216\u767d\u8272\u7684\u820c\u72b6\u5c0f\u82b1\uff0c\u56f4\u7ed5\u7740\u9ec4\u8272\u7684\u5706\u76d8\u5c0f\u82b1\uff08\u5982\u56fe\u6240\u793a\uff09\u00a0<strong>\u6570\u5b57\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/figure\/F1\/\" target=\"figure\" rel=\"noopener\">\u200b<span class=\"figpopup-sensitive-area\">\u56fe1<\/span>1<\/a><\/strong>\uff09\u3002\u7684\u5e72\u71e5\u5168\u8349\u00a0<em>\u706f\u76cf\u82b1<\/em>\u00a0\u5728\u6c11\u95f4\u533b\u5b66\u4e2d\u7528\u4e8e\u6cbb\u7597\u762b\u75ea\u3001\u98ce\u6e7f\u3001\u80c3\u708e\u3001\u7259\u75db\u548c\u53d1\u70e7\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B92\" aria-expanded=\"false\" aria-haspopup=\"true\">\u4e91\u5357\u836f\u7269\u7814\u7a76\u6240\uff0c1976<\/a>).<\/p>\n<div id=\"F1\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm140218700826464\"><img decoding=\"async\" class=\"fig-image\" title=\"\u5305\u542b\u56fe\u7247\u3001\u63d2\u56fe\u7b49\u7684\u5916\u90e8\u6587\u4ef6\u3002\u5bf9\u8c61\u540d\u79f0\u4e3a fphar-08-00289-g001.jpg\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/bin\/fphar-08-00289-g001.jpg\" alt=\"An external file that holds a picture, illustration, etc. Object name is fphar-08-00289-g001.jpg\" \/><\/div>\n<div id=\"lgnd_F1\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/figure\/F1\/\" target=\"figure\" rel=\"noopener\">\u56fe1<\/a><\/div>\n<div class=\"caption\">\n<p><strong>\u706f\u76cf\u82b1 (A)<\/strong>\u00a0\u82b1;\u00a0<strong>(\u4e8c)<\/strong>\u00a0\u5168\u682a\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p>\u706f\u76cf\u82b1\u7d20\u662f\u591a\u79cd\u9ec4\u916e\u7c7b\u5316\u5408\u7269\u7684\u7c97\u63d0\u7269\u00a0<em>\u706f\u76cf\u82b1 (Vant.) Hand.-Mazz.<\/em>\u00a0(<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B96\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f20\u7b49\u4eba\uff0c1988<\/a>\uff09\u53ef\u5236\u6210\u6ce8\u5c04\u5242\u3001\u9897\u7c92\u5242\u3001\u666e\u901a\u7247\u5242\u3001\u5206\u6563\u7247\u3001\u80f6\u56ca\u5242\u3001\u5408\u5242\u3001\u6ef4\u4e38\u5242\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B67\" aria-expanded=\"false\" aria-haspopup=\"true\">\u7530\u7b49\u4eba\uff0c2014<\/a>\uff09\u3002\u636e\u6211\u4eec\u6240\u77e5\uff0c\u706f\u76cf\u82b1\u7d20\u7684\u4e3b\u8981\u6d3b\u6027\u6210\u5206\u662f\u706f\u76cf\u4e59\u7d20\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B96\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f20\u7b49\u4eba\uff0c1988<\/a>\uff09\u3002\u706f\u76cf\u82b1\u7d20\u7528\u4e8e\u6cbb\u7597\u9ad8\u8840\u538b\u3001\u8111\u6813\u585e\u548c\u8111\u8840\u7ba1\u610f\u5916\u5bfc\u81f4\u7684\u762b\u75ea\u53ef\u4ee5\u8ffd\u6eaf\u5230 20 \u4e16\u7eaa 70 \u5e74\u4ee3\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B92\" aria-expanded=\"false\" aria-haspopup=\"true\">\u4e91\u5357\u836f\u7269\u7814\u7a76\u6240\uff0c1976<\/a>\uff09\u3002\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\u706f\u76cf\u82b1\u7d20\u53ef\u7528\u4e8e\u6cbb\u7597\u8111\u6897\u585e\u548c\u7cd6\u5c3f\u75c5\u80be\u75c5\u3002\u4e00\u9879\u968f\u673a\u548c\u534a\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u7684\u835f\u8403\u5206\u6790\u5c06\u706f\u76cf\u82b1\u7d20\u52a0\u5e38\u89c4\u6cbb\u7597\u4e0e\u5355\u72ec\u5e38\u89c4\u6cbb\u7597\u8fdb\u884c\u6bd4\u8f83\uff0c\u7ed3\u679c\u663e\u793a\u4f7f\u7528\u706f\u76cf\u82b1\u7d20\u5bf9\u60a3\u8005\u9884\u540e\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u76ca\u5904\uff0c\u795e\u7ecf\u7cfb\u7edf\u6709\u663e\u7740\u6539\u5584\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B88\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6768\u7b49\u4eba\uff0c2012<\/a>\uff09\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u53e6\u4e00\u9879\u706f\u76cf\u82b1\u7d20\u4e0e\u7532\u94b4\u80fa\u8054\u5408\u6cbb\u7597\u7cd6\u5c3f\u75c5\u5468\u56f4\u795e\u7ecf\u75c5\u53d8\u7684\u835f\u8403\u5206\u6790\u8868\u660e\uff0c\u8054\u5408\u6cbb\u7597\u7684\u7597\u6548\u4f18\u4e8e\u5355\u72ec\u4f7f\u7528\u7532\u94b4\u80fa\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B33\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5218\u7b49\u4eba\uff0c2016<\/a>\uff09\u3002\u53e6\u4e00\u9879\u5173\u4e8e\u706f\u76cf\u82b1\u7d20\u6ce8\u5c04\u6db2\u5bf9\u7cd6\u5c3f\u75c5\u80be\u75c5\u4e34\u5e8a\u53c2\u6570\u5f71\u54cd\u7684\u835f\u8403\u5206\u6790\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B101\" aria-expanded=\"false\" aria-haspopup=\"true\">\u90d1\u7b49\u4eba\uff0c2015<\/a>\uff09\u53d1\u73b0\u663e\u7740\u7684\u80be\u810f\u4fdd\u62a4\u4f5c\u7528\uff08\u964d\u4f4e\u5c3f\u86cb\u767d\u3001\u8840\u6e05\u808c\u9150\u548c\u8840\u5c3f\u7d20\u6c2e\uff09\u548c\u8c03\u8282\u8840\u8102\u5f02\u5e38\uff08\u5bf9\u80c6\u56fa\u9187\u3001\u7518\u6cb9\u4e09\u916f\uff08TG\uff09\u548c\u9ad8\u5bc6\u5ea6\u8102\u86cb\u767d\u6c34\u5e73\u7684\u5f71\u54cd\uff09\u3002<\/p>\n<p class=\"p\">\u76ee\u524d\uff0c\u7531\u4e8e\u5176\u5fc3\u8840\u7ba1\u836f\u7406\u4f5c\u7528\uff08<strong>\u8868\u683c\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/table\/T1\/\" target=\"table\" rel=\"noopener\">\u200b<span class=\"figpopup-sensitive-area\">\u88681\uff0c<\/span>1<\/a>,\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/table\/T2\/\" target=\"table\" rel=\"noopener\">\u200b<span class=\"figpopup-sensitive-area\">,2<\/span>2<\/a><\/strong>\uff09\u548c\u4e34\u5e8a\u76ca\u5904\uff08<strong>\u684c\u5b50\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/table\/T3\/\" target=\"table\" rel=\"noopener\">\u200b<span class=\"figpopup-sensitive-area\">\u88683<\/span>3<\/a><\/strong>\uff09\uff0c\u706f\u76cf\u82b1\u7d20\u5728\u4e2d\u56fd\u5df2\u5e7f\u6cdb\u7528\u4e8e\u4e0e\u897f\u836f\u8054\u5408\u6cbb\u7597\u7f3a\u8840\u6027\u5fc3\u8840\u7ba1\u75be\u75c5\uff0c\u5982\u5fc3\u7ede\u75db\u548c\u5fc3\u808c\u6897\u6b7b\uff08MI\uff09\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B4\" aria-expanded=\"false\" aria-haspopup=\"true\">\u66f9\u7b49\u4eba\uff0c2008<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B21\" aria-expanded=\"false\" aria-haspopup=\"true\">\u4ed6\u7b49\u4eba\uff0c2012<\/a>\uff09\u3002\u4e00\u9879\u8bc4\u4f30\u706f\u76cf\u82b1\u7d20\u8f85\u52a9\u6cbb\u7597\u5fc3\u7ede\u75db\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u835f\u8403\u5206\u6790\u8868\u660e\uff0c\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u6cbb\u7597\u7ec4\u5728\u4f7f\u5fc3\u7ede\u75db\u60a3\u8005\u53d7\u76ca\u65b9\u9762\u5177\u6709\u4f18\u52bf\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B47\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8042\u7b49\uff0c2012<\/a>\uff09\u3002\u6b64\u5916\uff0c\u706f\u76cf\u82b1\u7d20\u636e\u62a5\u9053\u5177\u6709\u5e7f\u6cdb\u7684\u5fc3\u8840\u7ba1\u836f\u7406\u4f5c\u7528\uff0c\u5305\u62ec\u8840\u7ba1\u8212\u5f20\u3001\u6297\u8840\u6813\u5f62\u6210\u4f5c\u7528\u3001\u8840\u5c0f\u677f\u805a\u96c6\u3001\u6297\u51dd\u3001\u6e05\u9664\u81ea\u7531\u57fa\u548c\u6539\u5584\u5fae\u5faa\u73af\u7b49\u3002\u00a0<em>\u4f53\u5185<\/em>\u00a0\u548c\u00a0<em>\u4f53\u5916<\/em>\u00a0\u5b9e\u9a8c\u3002\u706f\u76cf\u82b1\u7d20\u5177\u6709\u4e00\u7cfb\u5217\u836f\u7406\u7279\u6027\uff0c\u662f\u4e00\u79cd\u53ef\u7528\u4e8e\u4e34\u5e8a\u7684\u591a\u79cd\u9ec4\u916e\u7c7b\u5316\u5408\u7269\u7684\u6df7\u5408\u7269\uff0c\u4f46\u5176\u6f5c\u5728\u673a\u5236\u4ecd\u4e0d\u6e05\u695a\u3002<\/p>\n<div id=\"T1\" class=\"table-wrap anchored whole_rhythm\">\n<h3>\u8868\u683c1<\/h3>\n<div class=\"caption\">\n<p><em>\u4f53\u5185<\/em>\u00a0\u706f\u76cf\u82b1\u7d20\u548c\u706f\u76cf\u4e59\u7d20\u7684\u5fc3\u8840\u7ba1\u4f5c\u7528\u3002<\/p>\n<\/div>\n<div class=\"xtable\">\n<table class=\"rendered small default_table\" frame=\"hsides\" rules=\"groups\" cellspacing=\"5\" cellpadding=\"5\">\n<thead>\n<tr>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6548\u679c<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5316\u5408\u7269<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u52a8\u7269\/\u5668\u5b98<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u76ee\u6807<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u53c2\u8003<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">I\/R \u4fdd\u62a4\u6548\u679c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u4e59\u7d20\/\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u96c4\u6027\u65af\u666e\u62c9\u683c-\u9053\u5229 (SD) \u5927\u9f20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u808c\u6897\u6b7b\uff08MI\uff09\u5927\u5c0f\u5fc3\u808c\u7ec6\u80de\u51cb\u4ea1\uff1b<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B32\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6797\u7b49\u4eba\uff0c2007<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">I\/R \u4fdd\u62a4\u6548\u679c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">I\/R\u635f\u4f24\u5927\u9f20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">PI3K\/Akt\/eNOS \u4fe1\u53f7\u901a\u8def\u3002<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B73\" aria-expanded=\"false\" aria-haspopup=\"true\">\u738b\u6770\u7b49\uff0c2015<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">I\/R \u4fdd\u62a4\u6548\u679c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5de6\u5fc3I\/R\u5927\u9f20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">IL-18 \u548c ICAM-1<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B79\" aria-expanded=\"false\" aria-haspopup=\"true\">\u738b\u52c7\u7b49\uff0c2013<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6297\u708e\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u65b0\u897f\u5170\u5154\u7684\u5fc3\u808c I\/R<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u86cb\u767d\u8d28 TNF-\u03b1 \u548c NF-\u03baB<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B99\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8d75\uff0c2010<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6297\u708e\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u7f3a\u8840\u518d\u704c\u6ce8\u5927\u9f20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u86cb\u767d\u8d28 TNF-\u03b1 \u548c IL-6<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B15\" aria-expanded=\"false\" aria-haspopup=\"true\">\u9f9a\u7b49\uff0c2013<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6297\u51dd<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u8001\u9f20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u51dd\u8840\u65f6\u95f4\uff08CT\uff09\uff1b\u51dd\u8840\u9176\u539f\u65f6\u95f4\uff08PT\uff09\uff1b\u8840\u5c0f\u677f\u56e0\u5b50 III (PF3)\uff1b\u4f18\u7403\u86cb\u767d\u88c2\u89e3\u65f6\u95f4 (ELT)<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B80\" aria-expanded=\"false\" aria-haspopup=\"true\">\u738b\u7b49\u4eba\uff0c2003<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6297\u8840\u6813\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><em>\u706f\u76cf\u82b1<\/em>\u00a0\u9ec4\u916e\u7c7b<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5927\u9f20\/\u5154<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">ADP\u3001AA \u548c\u8840\u5c0f\u677f\u6fc0\u6d3b\u56e0\u5b50 (PAF)<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B61\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6c89\u7b49\u4eba\uff0c2000<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6297\u8840\u6813\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u9ec4\u82a9\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u8001\u9f20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">ADP\u8bf1\u5bfc\u8840\u5c0f\u677f<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B64\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5b8b\u7b49\uff0c2011<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5185\u76ae\u4fdd\u62a4\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u7ec6\u8f9b\u6ce8\u5c04\u6db2<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u7ef4\u65af\u5854\u9f20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u80bf\u7624\u574f\u6b7b\u56e0\u5b50-\u03b1\uff1b\u708e\u75c7\u53cd\u5e94<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B94\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f20\u7b49\u4eba\uff0c2009<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u808c\u4fdd\u62a4\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u538b\u529b\u8fc7\u8f7d\u5f15\u8d77\u7684\u5c0f\u9f20\u5fc3\u810f\u80a5\u5927<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">PKC-\u03b1 \u4f9d\u8d56\u6027 ERK1\/2 PI3K\/AKT \u4fe1\u53f7\u4f20\u5bfc<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B86\" aria-expanded=\"false\" aria-haspopup=\"true\">\u4e25\u7b49\u4eba\uff0c2010<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u808c\u4fdd\u62a4\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u9ec4\u82a9\u7519<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u8001\u9f20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u810f\u5185\u76ae-\u95f4\u8d28\u8f6c\u5316Notch\u901a\u8def<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B104\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5468\u7b49\uff0c2014<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u808c\u4fdd\u62a4\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u94fe\u8132\u4f50\u83cc\u7d20\u8bf1\u5bfc\u7684\u7cd6\u5c3f\u75c5\u5927\u9f20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u86cb\u767d\u6fc0\u9176C\uff08PKC\uff09\uff1b\u53d7\u78f7\u86cb\u767d\uff08PLB\uff09\uff1b\u86cb\u767d\u78f7\u9178\u9176\u6291\u5236\u5242-1 (PPI-1)\uff1b Ca(2+)-ATP \u9176 (SERCA-2)\uff1b\u5170\u5c3c\u78b1\u53d7\u4f53 (RyR)<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B77\" aria-expanded=\"false\" aria-haspopup=\"true\">\u738b\u7b49\u4eba\uff0c2010<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6297\u5fc3\u810f\u91cd\u6784\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u529b\u8870\u7aed\u5927\u9f20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u808c\u6536\u7f29\u548c\u8212\u5f20\u529f\u80fd<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B30\" aria-expanded=\"false\" aria-haspopup=\"true\">\u674e\uff0c2011<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u964d\u8102\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u7cd6\u5c3f\u75c5\u5927\u9f20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u8840\u8102<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B81\" aria-expanded=\"false\" aria-haspopup=\"true\">\u9b4f\u7b49\u4eba\uff0c2010<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u964d\u8102\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5154\u5b50<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5185\u819c\u589e\u751f\u4e0e\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u8fdb\u5c55<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B37\" aria-expanded=\"false\" aria-haspopup=\"true\">\u697c\u548c\u5218\uff0c2009<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6539\u5584\u52c3\u8d77\u529f\u80fd<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u81ea\u53d1\u6027\u9ad8\u8840\u538b\u5927\u9f20 (SHR)<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">RhoA\/Rho\u6fc0\u9176\u9014\u5f84<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B29\" aria-expanded=\"false\" aria-haspopup=\"true\">\u674e\u7b49\u4eba\uff0c2014<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div id=\"largeobj_idm140218659817184\" class=\"largeobj-link align_right\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/table\/T1\/?report=objectonly\" target=\"object\" rel=\"noopener\">\u5728\u5355\u72ec\u7684\u7a97\u53e3\u4e2d\u6253\u5f00<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<div><\/div>\n<div><\/div>\n<div id=\"abstract-a.k.b.n\" class=\"tsec sec\" lang=\"en\">\n<div id=\"sec-a.l.a\" class=\"tsec sec\">\n<div id=\"T2\" class=\"table-wrap anchored whole_rhythm\">\n<h3>\u88682<\/h3>\n<div class=\"caption\">\n<p><em>\u4f53\u5916<\/em>\u00a0\u706f\u76cf\u82b1\u7d20\u548c\u706f\u76cf\u4e59\u7d20\u7684\u5fc3\u8840\u7ba1\u4f5c\u7528\u3002<\/p>\n<\/div>\n<div class=\"xtable\">\n<table class=\"rendered small default_table\" frame=\"hsides\" rules=\"groups\" cellspacing=\"5\" cellpadding=\"5\">\n<thead>\n<tr>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6548\u679c<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5316\u5408\u7269<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u7ec6\u80de\/\u7ec4\u7ec7<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u76ee\u6807<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u53c2\u8003<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u8840\u7ba1\u8212\u5f20\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5927\u9f20\u4e3b\u52a8\u8109\u5e73\u6ed1\u808c\u7ec6\u80de\uff08ASMC\uff09<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">Ca2+ \u4f9d\u8d56\u6027 K+ \u901a\u9053 \u901a\u9053\u5f00\u653e\u6982\u7387 (Po) \u901a\u9053\u7535\u5bfc<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B84\" aria-expanded=\"false\" aria-haspopup=\"true\">\u79c0\u7434, 2006<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u9488\u5bf9 I\/R \u7684\u4fdd\u62a4\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u8840\u6e05\u548c\u5fc3\u808c\u7ec4\u7ec7<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u808cICAM-I\u86cb\u767dNa(+)-K(+)-ATP\u9176\u3001Mg(2+)-ATP\u9176\u3001\u5fc3\u808c\u7ebf\u7c92\u4f53Ca(2+)-ATP\u9176<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B23\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8d3e\u7b49\u4eba\uff0c2008<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6297\u51dd<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5185\u76ae\u7ec6\u80de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u8840\u6813\u8c03\u8282\u86cb\u767d<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B105\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5468\u7b49\u4eba\uff0c1992<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5185\u76ae\u4fdd\u62a4\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u4eba\u8110\u9759\u8109\u5185\u76ae\u7ec6\u80de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6297\u6c27\u5316\u4f5c\u7528\uff1b NF-\u03baB \u6fc0\u6d3b<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B5\" aria-expanded=\"false\" aria-haspopup=\"true\">\u9648\u7b49\u4eba\uff0c2015<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5185\u76ae\u4fdd\u62a4\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u9ec4\u82a9\u7519<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u4eba\u8110\u9759\u8109\u5185\u76ae\u7ec6\u80de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">VEGF\u589e\u52a0<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B31\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6797\u7b49\u4eba\uff0c2011<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u808c\u4fdd\u62a4\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u808c\u7ec6\u80de\u7f3a\u6c27<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">LDH \u6e17\u6f0f \u7ec6\u80de\u5185\u6e38\u79bb Ca2+ \u6c34\u5e73 \u7ec6\u80de\u51cb\u4ea1\u574f\u6b7b<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B28\" aria-expanded=\"false\" aria-haspopup=\"true\">\u674e\u7b49\u4eba\uff0c2004<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u808c\u4fdd\u62a4\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u57f9\u517b\u7684\u65b0\u751f\u5927\u9f20\u5fc3\u808c\u7ec6\u80de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">PKC-\u03b1 \u4f9d\u8d56\u6027 ERK1\/2\uff1b PI3K\/AKT \u4fe1\u53f7\u8f6c\u5bfc<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B86\" aria-expanded=\"false\" aria-haspopup=\"true\">\u4e25\u7b49\u4eba\uff0c2010<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u51cf\u5c11\u5e73\u6ed1\u808c\u7ec6\u80de\u8fc1\u79fb\u548c\u589e\u6b96<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5927\u9f20\u4e3b\u52a8\u8109\u5e73\u6ed1\u808c\u7ec6\u80de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u51dd\u8840\u9176\/\u51dd\u8840\u9176\u53d7\u4f53\u57fa\u56e0<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B22\" aria-expanded=\"false\" aria-haspopup=\"true\">\u4faf\u7b49\u4eba\uff0c2009<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u51cf\u5c11\u5e73\u6ed1\u808c\u7ec6\u80de\u8fc1\u79fb\u548c\u589e\u6b96<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5154\u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de\uff08VSMC\uff09<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">VSMC NF-\u03baB \u6d3b\u6027<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B49\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5e9e\u7b49\u4eba\uff0c2004<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u51cf\u5c11\u5e73\u6ed1\u808c\u7ec6\u80de\u8fc1\u79fb\u548c\u589e\u6b96<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">ERK1\/2 MAPK \u4fe1\u53f7\u4f20\u5bfc<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B21\" aria-expanded=\"false\" aria-haspopup=\"true\">\u4ed6\u7b49\u4eba\uff0c2012<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6297\u5fc3\u5f8b\u5931\u5e38\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5927\u9f20\u5fc3\u5ba4\u808c\u7ec6\u80de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u94be\u7535\u6d41\uff08Ito\uff09<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B6\" aria-expanded=\"false\" aria-haspopup=\"true\">\u9093\u7b49\uff0c2008<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6297\u5fc3\u5f8b\u5931\u5e38\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5927\u9f20\u5fc3\u5ba4\u808c\u7ec6\u80de<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">INa \u901a\u9053\u7535\u6d41<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B65\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5510\u7b49\u4eba\uff0c2009<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u8840\u7ba1\u8212\u5f20\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5927\u9f20\u79bb\u4f53\u80f8\u4e3b\u52a8\u8109\u73af<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u53d7\u4f53\u64cd\u7eb5\u7684\u9499\u901a\u9053<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B102\" aria-expanded=\"false\" aria-haspopup=\"true\">\u90d1\u7b49\u4eba\uff0c1998<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6297\u5fc3\u5f8b\u5931\u5e38\u4f5c\u7528<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u706f\u76cf\u82b1\u7d20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5154\u5fc3\u810f\u80a5\u5927<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u8de8\u58c1\u590d\u6781\u5316\u8272\u6563\uff1b (TDR) \u53bb\u6781\u5316\u540e\u65e9\u671f\uff1b (EAD) \u5c16\u7aef\u626d\u8f6c\u578b\u5ba4\u901f\uff1b \uff08\u603b\u6e29\u5ea6\uff09<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B1\" aria-expanded=\"false\" aria-haspopup=\"true\">\u535a\u7b49\u4eba\uff0c2011<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div id=\"largeobj_idm140218663351120\" class=\"largeobj-link align_right\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/table\/T2\/?report=objectonly\" target=\"object\" rel=\"noopener\">\u5728\u5355\u72ec\u7684\u7a97\u53e3\u4e2d\u6253\u5f00<\/a><\/div>\n<div><\/div>\n<\/div>\n<div id=\"T3\" class=\"table-wrap anchored whole_rhythm\">\n<h3>\u88683<\/h3>\n<div class=\"caption\">\n<p>\u5305\u62ec\u706f\u76cf\u82b1\u7d20\u6cbb\u7597\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u8bd5\u9a8c\u3002<\/p>\n<\/div>\n<div class=\"xtable\">\n<table class=\"rendered small default_table\" frame=\"hsides\" rules=\"groups\" cellspacing=\"5\" cellpadding=\"5\">\n<thead>\n<tr>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u76ee\u6807<sup>A<\/sup><\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u8bbe\u8ba1<sup>\u4e59<\/sup><\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u671f\u95f4<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u5242\u91cf<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u6848\u4f8b\/\u5bf9\u7167<\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u4e3b\u8981\u7ed3\u679c\u6307\u6807<sup>C<\/sup><\/th>\n<th colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u53c2\u8003<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6811\u6db2<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">14\u5929<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">40 \u6beb\u514b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">25\/25<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5178\u578b\u75c7\u72b6\u3001\u5fc3\u7535\u56feST-T\u6539\u5584\u60c5\u51b5\u53ca\u52a8\u6001\u5fc3\u7535\u56feST-T\u65f6\u95f4<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B95\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f20\u548c\u5f20\uff0c2012<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u8054\u5408\u5e94\u7528\u7a0b\u5e8f<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">2\u5468<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">20 \u6beb\u5347\uff0c\u6bcf\u65e5\u4e00\u6b21<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">53\/51<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u785d\u9178\u5f02\u5c71\u68a8\u916f\u7528\u91cf\u3001\u5fc3\u7535\u56fe\u7597\u6548\u3001WBHV\u3001PV\u3001FIB\u3001hs-CRP\u3001\u7ea2\u7ec6\u80de\u805a\u96c6\u6307\u6570<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B60\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6c89\u7b49\u4eba\uff0c2014<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6025\u6027\u5fc3\u808c\u6897\u6b7b<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u76f8\u5173\u8272\u6e29<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">10\u5929<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">60 \u6beb\u514b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">25\/20<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">LVEF\u3001\u5916\u5468\u8840\u7ba1\u963b\u529b\u4e0e\u540e\u5fc3\u7ede\u75db\u53d1\u751f\u7387<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B18\" aria-expanded=\"false\" aria-haspopup=\"true\">\u987eTB\u7b49\uff0c2002<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6025\u6027\u5fc3\u808c\u6897\u6b7b<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">14\u5929<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">100 \u6beb\u514b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">60\/60<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u529f\u80fd\u7684\u6539\u5584\u3001\u5fc3\u810f\u4e0d\u826f\u4e8b\u4ef6\u7684\u53d1\u751f\u7387<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B87\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6768\u548c\u9648\uff0c2013<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u6025\u6027\u5fc3\u808c\u6897\u6b7b<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">14\u5929<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">50 \u6beb\u514b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">54\/54<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u8fd0\u52a8\u5f15\u8d77\u5fc3\u7535\u56feST\u6bb5\u538b\u4f4e\u7684\u65f6\u95f4\u3001ST\u6bb5\u538b\u4f4e\u6301\u7eed\u65f6\u95f4\u7684\u7f29\u77ed<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B76\" aria-expanded=\"false\" aria-haspopup=\"true\">\u738b\u7b49\u4eba\uff0c2009<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u57c3\u5e0c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">4-6\u5468<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">40 \u6beb\u5347\uff0c\u6bcf\u65e5\u4e00\u6b21<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">25\/25<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5c3fNAG\u548c\u03b2\u7684\u91cf<sub>2<\/sub>- MG\u3001\u8840\u538b<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B72\" aria-expanded=\"false\" aria-haspopup=\"true\">\u738b\uff0c2000<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u9ad8\u7ea7\u536b\u751f\u4fdd\u5065\u4e2d\u5fc3<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">14\u5929<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">10 \u6beb\u5347\uff0c\u6bcf\u65e5\u4e00\u6b21<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">39\/39<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u8840\u80bf\u91cf\u3001\u6c34\u80bf\u9762\u79ef\u3001\u65af\u582a\u7684\u7eb3\u7ef4\u4e9a\u5352\u4e2d\u91cf\u8868 (SSS)<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B63\" aria-expanded=\"false\" aria-haspopup=\"true\">\u65bd\u548c\u4e01\uff0c2009<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">AF<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u6848\u4f8b\u7cfb\u5217<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">2\u5468<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">36 \u6beb\u514b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">20\/-<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5fc3\u7387<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B19\" aria-expanded=\"false\" aria-haspopup=\"true\">\u97e9, 1999<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u9ad8\u8102\u8840\u75c7<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u6848\u4f8b\u7cfb\u5217<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">2\u5468<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">25 \u6beb\u514b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">25\/-<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">TC\u3001LDL-c\u3001HDL-c \u548c TG<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B91\" aria-expanded=\"false\" aria-haspopup=\"true\">\u4f59, 2011<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u9ad8\u8102\u8840\u75c7<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u6848\u4f8b\u7cfb\u5217<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">4\u5468<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">30 \u6beb\u5347\uff0c\u6bcf\u65e5\u4e00\u6b21<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">36\/-<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">TC\u3001LDL-c\u3001HDL-c \u548c TG<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B82\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6587\u548c\u962e\uff0c2004<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">UPA\u548c\u9ad8\u8102\u8840\u75c7<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">2\u5468<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">50 \u6beb\u514b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">30\/32<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u8840\u8102\u3001WBV\u3001PV\u3001\u5fc3\u7ede\u75db\u6b21\u6570<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B51\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f6d\u548c\u53f6\uff0c2011<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u75c5\u6bd2\u6027\u5fc3\u808c\u708e<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u76f8\u5173\u8272\u6e29<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">2\u5468<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">10 \u6beb\u514b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">40\/30<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u76f4\u6d41\u3001CK-MB<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B17\" aria-expanded=\"false\" aria-haspopup=\"true\">\u987e\u7b49\uff0c2014<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u75c5\u6bd2\u6027\u5fc3\u808c\u708e<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">2\u5468<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">10 \u6beb\u514b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">30\/30<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u80bf\u7624\u574f\u6b7b\u56e0\u5b50-\u03b1<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B78\" aria-expanded=\"false\" aria-haspopup=\"true\">\u738b\u548c\u738b\uff0c2009<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u9ad8\u9891NEF<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">10\u5929<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">40 \u6beb\u514b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">50\/50<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">BNP\u3001LVEF\u3001LVEDV\u3001\u5178\u578b\u75c7\u72b6<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B93\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f20\u82b3, 2014<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u9ad8\u9891<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">14\u5929<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">50 \u6beb\u514b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">64\/62<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5de6\u5fc3\u5ba4\u5c04\u8840\u5206\u6570\uff0c6-MWT<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B68\" aria-expanded=\"false\" aria-haspopup=\"true\">\u7530, 2010<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u4e25\u91cd\u5fc3\u529b\u8870\u7aed<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u76f8\u5173\u8272\u6e29<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">14\u5929<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">50 \u6beb\u514b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">46\/23<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">LVEF\u3001LVEDV\u30016-MWT<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B27\" aria-expanded=\"false\" aria-haspopup=\"true\">\u674e\uff0c2007<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u535a\u58eb\u751f<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">28\u5929<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">40 \u6beb\u514b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">42\/41<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">bFGF\u3001PaO<sub>2<\/sub>, \u5e73\u5747\u538b\u529b<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B13\" aria-expanded=\"false\" aria-haspopup=\"true\">\u9ad8\u548c\u6881\uff0c2009<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u5931\u4ee3\u507f\u6027\u6162\u6027PHD<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u76f8\u5173\u8272\u6e29<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">20\u5929<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">50 \u6beb\u514b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">38\/46<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">\u7ea2\u7ec6\u80de\u53d8\u5f62\u80fd\u529b\u548c\u767d\u7ec6\u80de\u6d3b\u5316\u80fd\u529b<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B25\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5b54\u7b49\u4eba\uff0c2006<\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">PHD \u6025\u6027\u52a0\u91cd<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">\u76f8\u5173\u8272\u6e29<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">2\u5468<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">20 \u6beb\u514b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"center\" valign=\"top\">104\/104<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\">WBV\u3001FIB\u3001\u5178\u578b\u75c7\u72b6<\/td>\n<td colspan=\"1\" rowspan=\"1\" align=\"left\" valign=\"top\"><a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B3\" aria-expanded=\"false\" aria-haspopup=\"true\">\u66f9\u7b49\u4eba\uff0c2006<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div id=\"largeobj_idm140218699722016\" class=\"largeobj-link align_right\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/table\/T3\/?report=objectonly\" target=\"object\" rel=\"noopener\">\u5728\u5355\u72ec\u7684\u7a97\u53e3\u4e2d\u6253\u5f00<\/a><\/div>\n<div class=\"tblwrap-foot\">\n<div class=\"half_rhythm align_right attrib\">\n<p>&nbsp;<\/p>\n<p><sup>A<\/sup>SAP\uff0c\u7a33\u5b9a\u578b\u5fc3\u7ede\u75db\uff1b UAP\uff0c\u4e0d\u7a33\u5b9a\u578b\u5fc3\u7ede\u75db\uff1b AMI\uff0c\u6025\u6027\u5fc3\u808c\u6897\u585e\uff1b EH\uff0c\u539f\u53d1\u6027\u9ad8\u8840\u538b\uff1b AHCH\uff0c\u6025\u6027\u9ad8\u8840\u538b\u8111\u51fa\u8840\uff1b AF\uff0c\u5fc3\u623f\u98a4\u52a8\uff1b\u5fc3\u529b\u8870\u7aed\uff0c\u5fc3\u529b\u8870\u7aed\uff1b HF-NEF\uff0c\u5c04\u8840\u5206\u6570\u6b63\u5e38\u7684\u5fc3\u529b\u8870\u7aed\uff1b\u535a\u58eb\uff0c\u80ba\u5fc3\u75c5\u3002\u00a0<sup>\u4e59<\/sup>RCT\uff0c\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff1b CCT\uff0c\u4e34\u5e8a\u5bf9\u7167\u8bd5\u9a8c\u3002\u00a0<sup>C<\/sup>WBV\uff0c\u5168\u8840\u7c98\u5ea6\uff1b PV\u3001\u8840\u6d46\u7c98\u5ea6\uff1b FIB\uff0c\u7ea4\u7ef4\u86cb\u767d\u539f\uff1b WBHV\uff0c\u5168\u8840\u9ad8\u7c98\u5ea6\uff1b LVEF\uff0c\u5de6\u5fc3\u5ba4\u5c04\u8840\u5206\u6570\uff1b TC\uff0c\u603b\u80c6\u56fa\u9187\uff1b TG\u3001\u7518\u6cb9\u4e09\u916f\uff1b\u76f4\u6d41\u3001\u51cf\u901f\u80fd\u529b\uff1b LVEDV\uff0c\u5de6\u5fc3\u5ba4\u8212\u5f20\u672b\u671f\u5bb9\u79ef\uff1b 6-MWT\uff0c6 \u5206\u949f\u6b65\u884c\u6d4b\u8bd5\uff1b bFGF\uff0c\u78b1\u6027\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff1b\u6c27\u5206\u538b<sub>2<\/sub>, \u6c27\u5206\u538b; mPAP\uff0c\u5e73\u5747\u80ba\u52a8\u8109\u538b\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div><\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"sec-a.l.b\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"sec-a.l.btitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u65b9\u6cd5<\/h2>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u4f7f\u7528\u672f\u8bed\u201cBreviscapine\u201d\u6216\u201c<em>\u706f\u76cf\u82b1<\/em>\u201c \u6216\u8005 \u201d<em>\u706f\u76cf\u7ec6\u8f9b<\/em>\u201c \u6216\u8005 \u201d<em>\u706f\u83ca<\/em>\u201d\u6216\u201c\u706f\u76cf\u4e59\u7d20\u201d\u6216\u201c\u82b9\u83dc\u7d20-7-<em>\u6c27<\/em>-glucuronide\u201d\u6216\u201cdengzhanxixin\u201d\u4f5c\u4e3a\u201c\u6807\u9898\/\u6458\u8981\u201d\u6216 MeSH \u672f\u8bed\u201cBreviscapine\u201d\u6216\u201cscutellarin-7-<em>\u6c27<\/em>-\u8461\u8404\u7cd6\u82f7\u9178\u201d\u3002\u4e0e\u5fc3\u8840\u7ba1\u75be\u75c5\uff08CVD\uff09\u6cbb\u7597\u6548\u679c\u76f8\u5173\u7684\u6587\u7ae0\u662f\u4eba\u5de5\u6311\u9009\u7684\u3002\u6240\u6709\u5e26\u6709\u6458\u8981\u7684\u6587\u7ae0\u90fd\u5305\u542b\u5728\u5185\uff0c\u5e76\u4e14\u6211\u4eec\u6ca1\u6709\u5e94\u7528\u8bed\u8a00\u9650\u5236\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.c\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"sec-a.l.ctitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u5316\u5b66\u6210\u5206<\/h2>\n<p>&nbsp;<\/p>\n<p class=\"p p-first\">\u706f\u76cf\u82b1\u7d20\u4e3b\u8981\u542b\u6709\u706f\u76cf\u4e59\u7d20\uff084\u2032,5,6,7-\u56db\u7f9f\u57fa\u9ec4\u916e-7-<em>\u6c27<\/em>-\u8461\u8404\u7cd6\u919b\u9178\u82f7\uff09\u548c\u82b9\u83dc\u7d20-7-<em>\u6c27<\/em>-\u8461\u8404\u7cd6\u82f7\u9178\u3002\u706f\u76cf\u4e59\u7d20\u662f\u4e3b\u8981\u6d3b\u6027\u6210\u5206\u3002\u5176\u5206\u5b50\u5f0f\u4e3aC<sub>21<\/sub>H<sub>18<\/sub>\u6c27<sub>12<\/sub>\uff0c\u76f8\u5bf9\u5206\u5b50\u8d28\u91cf\u4e3a462.35\u3002\u5176\u5316\u5b66\u7ed3\u6784\u5982\u56fe\u00a0<strong>\u6570\u5b57\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\u200b<span class=\"figpopup-sensitive-area\">\u56fe2<\/span>2<\/a><\/strong>\u3002\u4f46\u706f\u76cf\u82b1\u4e59\u7d20\u6c34\u6eb6\u6027\u4f4e\u3001\u5316\u5b66\u7a33\u5b9a\u6027\u5dee\u3001\u751f\u7269\u534a\u8870\u671f\u77ed\u3001\u8840\u6d46\u6d88\u9664\u7387\u5feb\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B20\" aria-expanded=\"false\" aria-haspopup=\"true\">\u90dd\u7b49\u4eba\uff0c2005<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B38\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5362\u7b49\uff0c2010<\/a>\uff09\u3002\u82b9\u83dc\u7d20-7-\u7684\u5316\u5b66\u7ed3\u6784<em>\u6c27<\/em>-\u8461\u8404\u7cd6\u919b\u9178\u82f7\u663e\u793a\u5728\u00a0<strong>\u6570\u5b57\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/figure\/F3\/\" target=\"figure\" rel=\"noopener\">\u200b<span class=\"figpopup-sensitive-area\">\u56fe3<\/span>3<\/a><\/strong>;\u5b83\u7684\u5206\u5b50\u5f0f\u662fC<sub>21<\/sub>H<sub>18<\/sub>\u6c27<sub>11<\/sub>\u00a0\u76f8\u5bf9\u5206\u5b50\u8d28\u91cf\u4e3a446\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B83\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5434\uff0c2011<\/a>).<\/p>\n<div id=\"F2\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm140218698629024\"><img decoding=\"async\" class=\"fig-image\" title=\"\u5305\u542b\u56fe\u7247\u3001\u63d2\u56fe\u7b49\u7684\u5916\u90e8\u6587\u4ef6\u3002\u5bf9\u8c61\u540d\u79f0\u4e3a fphar-08-00289-g002.jpg\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/bin\/fphar-08-00289-g002.jpg\" alt=\"An external file that holds a picture, illustration, etc. Object name is fphar-08-00289-g002.jpg\" \/><\/div>\n<div id=\"lgnd_F2\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\u56fe2<\/a><\/div>\n<div class=\"caption\">\n<p><strong>\u706f\u76cf\u82b1\u4e59\u7d20\u7684\u7ed3\u6784<\/strong>.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"F3\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm140218698625760\"><img decoding=\"async\" class=\"fig-image\" title=\"\u5305\u542b\u56fe\u7247\u3001\u63d2\u56fe\u7b49\u7684\u5916\u90e8\u6587\u4ef6\u3002\u5bf9\u8c61\u540d\u79f0\u4e3a fphar-08-00289-g003.jpg\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/bin\/fphar-08-00289-g003.jpg\" alt=\"An external file that holds a picture, illustration, etc. Object name is fphar-08-00289-g003.jpg\" \/><\/div>\n<div id=\"lgnd_F3\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/figure\/F3\/\" target=\"figure\" rel=\"noopener\">\u56fe3<\/a><\/div>\n<div class=\"caption\">\n<p><strong>\u82b9\u83dc\u7d20-7-\u7684\u7ed3\u6784<em>\u6c27<\/em>-\u8461\u8404\u7cd6\u82f7\u9178<\/strong>.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"sec-a.l.d\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"sec-a.l.dtitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u5bf9\u5fc3\u8840\u7ba1\u7684\u5f71\u54cd<\/h2>\n<div id=\"sec-a.l.d.b\" class=\"sec sec-first\">\n<h3 id=\"sec-a.l.d.btitle\">\u8840\u7ba1\u8212\u5f20\u4f5c\u7528<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u6267\u884c\u7ef4\u6301\u8840\u7ba1\u7a33\u6001\u529f\u80fd\u7684\u8109\u7ba1\u7cfb\u7edf\u5728\u7ef4\u6301\u8840\u538b\u548c\u6839\u636e\u52a8\u6001\u8eab\u4f53\u72b6\u51b5\u63d0\u4f9b\u9002\u5f53\u7684\u8840\u6db2\u704c\u6d41\u65b9\u9762\u53d1\u6325\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u4f5c\u4e3a\u5176\u8c03\u8282\u673a\u5236\u4e4b\u4e00\uff0c\u8840\u7ba1\u5e73\u6ed1\u808c\uff08VSM\uff09\u7684\u677e\u5f1b\u53ef\u4ee5\u901a\u8fc7\u4e00\u7cfb\u5217\u5185\u76ae\u4f9d\u8d56\u6027\u548c\u975e\u5185\u76ae\u4f9d\u8d56\u6027\u56e0\u5b50\u7684\u91ca\u653e\u6765\u89e6\u53d1\uff0c\u5e76\u5df2\u88ab\u8bc1\u660e\u4e0e\u03b1\u53d7\u4f53\u3001\u03b2\u53d7\u4f53\u6709\u5173\u3002\u53d7\u4f53\uff0c\u9499<sup>2+<\/sup>\u00a0\u901a\u9053\u548c\u9499<sup>2+<\/sup>\u4f9d\u8d56K<sup>+<\/sup>\u00a0\u7ec6\u80de\u819c\u4e0a\u7684\u901a\u9053\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B12\" aria-expanded=\"false\" aria-haspopup=\"true\">\u798f\u5947\u6208\u7279\uff0c1983<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B54\" aria-expanded=\"false\" aria-haspopup=\"true\">\u62c9\u6ce2\u6ce2\u7279\u7b49\u4eba\uff0c1983<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B66\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5854\u96f7\u7b49\u4eba\uff0c1990<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B2\" aria-expanded=\"false\" aria-haspopup=\"true\">\u535a\u6d1b\u8482\u7eb3\u7b49\u4eba\uff0c1994<\/a>\uff09\u3002\u57fa\u4e8e\u00a0<em>\u4f53\u5916<\/em>\u00a0\u7814\u7a76\u8868\u660e\uff0c\u706f\u76cf\u82b1\u7d20\u53ef\u4ee5\u4ee5\u6d53\u5ea6\u4f9d\u8d56\u7684\u65b9\u5f0f\u677e\u5f1b\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u5f15\u8d77\u7684\u8840\u7ba1\u6536\u7f29\uff0c\u800c\u4e0d\u5f71\u54cd\u5185\u76ae\u529f\u80fd\uff0c\u4e0d\u8c03\u6574\u03b1\u53d7\u4f53\u548c\u03b2\u53d7\u4f53\uff0c\u5c3d\u7ba1\u6709\u4eba\u8ba4\u4e3a\u5176\u8840\u7ba1\u8212\u5f20\u4f5c\u7528\u53ef\u80fd\u4e0e\u53d7\u4f53\u64cd\u7eb5\u7684\u9499\u901a\u9053\u7684\u6291\u5236\u6709\u5173\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B102\" aria-expanded=\"false\" aria-haspopup=\"true\">\u90d1\u7b49\u4eba\uff0c1998<\/a>\uff09\u3002\u8fd8\u6709\u53e6\u4e00\u79cd\u00a0<em>\u4f53\u5185<\/em>\u00a0\u7814\u7a76\u8868\u660e\u9499\u6fc0\u6d3b\u94be\u901a\u9053\uff08K<sub>\u9499<\/sub>\uff09\u53ef\u4ee5\u901a\u8fc7\u5728\u5927\u9f20\u4e3b\u52a8\u8109\u5e73\u6ed1\u808c\u7ec6\u80de\uff08ASMC\uff09\u4e2d\u5e94\u7528\u706f\u76cf\u82b1\u7d20\uff0c\u901a\u8fc7\u4fc3\u8fdb\u901a\u9053\u7684\u5f00\u653e\u6982\u7387\uff08Po\uff09\u548c\u589e\u5f3a\u901a\u9053\u7535\u5bfc\u6765\u6fc0\u6d3b\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B84\" aria-expanded=\"false\" aria-haspopup=\"true\">\u79c0\u7434, 2006<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.d.c\" class=\"sec\">\n<h3 id=\"sec-a.l.d.ctitle\">\u5bf9\u7f3a\u8840\/\u518d\u704c\u6ce8 (I\/R) \u7684\u4fdd\u62a4\u4f5c\u7528<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">I\/R\u635f\u4f24\u5e38\u8868\u73b0\u4e3a\u5185\u76ae\u635f\u4f24\u52a0\u91cd\uff0c\u5bfc\u81f4\u5fc3\u808c\u7ec6\u80de\u52a0\u901f\u51cb\u4ea1\u6216\u6b7b\u4ea1\uff0c\u8fd9\u53ef\u4ee5\u901a\u8fc7MI\u7684\u5927\u5c0f\u6765\u8861\u91cf\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B24\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5b54\u7b49\u4eba\uff0c2016<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B90\" aria-expanded=\"false\" aria-haspopup=\"true\">\u4f59\u7b49\u4eba\uff0c2016<\/a>\uff09\u3002\u7814\u7a76\u8868\u660e\uff0c\u5355\u72ec\u4f7f\u7528\u706f\u76cf\u82b1\u4e59\u7d20\u5bf9\u5fc3\u808c\u6897\u6b7b\u5927\u9f20\u5fc3\u8840\u7ba1\u7f3a\u8840\u7684\u4fdd\u62a4\u4f5c\u7528\u5728\u5fc3\u808c\u6897\u6b7b\u5927\u5c0f\u548c\u5fc3\u808c\u7ec6\u80de\u51cb\u4ea1\u65b9\u9762\u4f18\u4e8e\u706f\u76cf\u82b1\u7d20\uff0c\u4e14\u5176\u4f5c\u7528\u5177\u6709\u5242\u91cf\u4f9d\u8d56\u6027\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B32\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6797\u7b49\u4eba\uff0c2007<\/a>\uff09\u3002\u5fc3\u808cI\/R\u635f\u4f24\u7684\u53d1\u751f\u5df2\u88ab\u8bc1\u660e\u6d89\u53ca\u591a\u79cd\u673a\u5236\uff0c\u5305\u62ec\u5e72\u6270\u8c03\u8282\u67d0\u4e9b\u57fa\u56e0\u8868\u8fbe\u7684\u7279\u5b9a\u9014\u5f84\u4ee5\u53ca\u6fc0\u6d3b\u76f8\u5173ATP\u9176\u3002\u4e00\u9879\u7814\u7a76\u8868\u660e\u706f\u76cf\u82b1\u7d20\u53ef\u4ee5\u5bf9 MI I\/R \u635f\u4f24\u63d0\u4f9b\u663e\u7740\u7684\u4fdd\u62a4\u4f5c\u7528\uff0c\u5176\u673a\u5236\u53ef\u80fd\u6d89\u53ca\u901a\u8fc7\u6fc0\u6d3b PI3K\/Akt\/eNOS \u4fe1\u53f7\u901a\u8def\u6291\u5236\u5fc3\u808c\u7ec6\u80de\u51cb\u4ea1\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B73\" aria-expanded=\"false\" aria-haspopup=\"true\">\u738b\u6770\u7b49\uff0c2015<\/a>\uff09\u3002\u6b64\u5916\uff0c\u53e6\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u706f\u76cf\u82b1\u7d20\u53ef\u4ee5\u6291\u5236 IL-18 \u548c ICAM-1 \u7684\u8868\u8fbe\uff0c\u4ece\u800c\u4fdd\u62a4\u80ba\u90e8\u514d\u53d7\u708e\u75c7\u7ea7\u8054\u53cd\u5e94\u7684\u5f71\u54cd\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B79\" aria-expanded=\"false\" aria-haspopup=\"true\">\u738b\u52c7\u7b49\uff0c2013<\/a>\uff09\u3002\u6b64\u5916\uff0c\u706f\u76cf\u82b1\u7d20\u7684\u4fdd\u62a4\u4f5c\u7528\u4e0e\u6e05\u9664\u6c27\u81ea\u7531\u57fa\u3001\u964d\u4f4e\u5fc3\u808cICAM-I\u86cb\u767d\u8868\u8fbe\u3001\u589e\u52a0Na(+)-K(+)-ATPase\u3001Mg(\u5fc3\u808c\u7ebf\u7c92\u4f53\u4e2d\u7684 2+)-ATP \u9176\u3001Ca(2+)-ATP \u9176\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B23\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8d3e\u7b49\u4eba\uff0c2008<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.d.d\" class=\"sec\">\n<h3 id=\"sec-a.l.d.dtitle\">\u6297\u708e\u4f5c\u7528<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u708e\u75c7\u8fc7\u7a0b\u5728 CVD \u53ca\u5176\u76f8\u5173\u5e76\u53d1\u75c7\u7684\u53d1\u751f\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B58\" aria-expanded=\"false\" aria-haspopup=\"true\">\u9c81\u5e15\u96f7\u5229\u4e9a\u7b49\u4eba\uff0c2017<\/a>\uff09\u3002\u52a8\u8109\u7ca5\u6837\u786c\u5316\u88ab\u8ba4\u4e3a\u662f\u4e00\u79cd\u708e\u75c7\u6027\u75be\u75c5\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B57\" aria-expanded=\"false\" aria-haspopup=\"true\">\u7f57\u65af\uff0c1999<\/a>\uff09\u3002\u8bb8\u591a\u751f\u7269\u56e0\u7d20\uff0c\u5982\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\u3001\u9176\u548c\u5176\u4ed6\u4ecb\u8d28\u5df2\u88ab\u8bc1\u660e\u4e0e\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u5f71\u54cd\u6709\u5173\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B70\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6c83\u5c14\u4ec0\uff0c2003<\/a>\uff09\u3002\u5df2\u8bc1\u660e\u706f\u76cf\u82b1\u7d20\u80fd\u591f\u6cbb\u7597\u51a0\u5fc3\u75c5\u5e76\u51cf\u5c11\u76f8\u5173\u7684\u708e\u75c7\u53cd\u5e94\u3002\u4e00\u9879\u6bd4\u8f83\u7f3a\u8840\u9884\u5904\u7406\u4e0e\u706f\u76cf\u82b1\u7d20\u548c\u5355\u72ec\u7f3a\u8840\u9884\u5904\u7406\u7684\u7814\u7a76\u8bc1\u660e\u4e86\u89c2\u5bdf\u5230\u7684\u706f\u76cf\u82b1\u7d20\u7684\u6297\u708e\u4f5c\u7528\uff1b\u8054\u5408\u6cbb\u7597\u5bf9\u65b0\u897f\u5170\u5154\u5fc3\u808cI\/R\u8fc7\u7a0b\u4e2d\u964d\u4f4eTNF-\u03b1\u548cNF-\u03baB\u7684\u8868\u8fbe\u3001\u51cf\u8f7b\u708e\u75c7\u635f\u4f24\u8fbe\u5230\u5fc3\u808c\u4fdd\u62a4\u4f5c\u7528\u6548\u679c\u8f83\u597d\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B99\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8d75\uff0c2010<\/a>\uff09\u3002\u540c\u6837\uff0c\u5b83\u8fd8\u53ef\u4ee5\u964d\u4f4eTNF-\u03b1\u548cIL-6\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u51cf\u8f7b\u5927\u9f20I\/R\u7684\u635f\u4f24\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B15\" aria-expanded=\"false\" aria-haspopup=\"true\">\u9f9a\u7b49\uff0c2013<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.d.e\" class=\"sec\">\n<h3 id=\"sec-a.l.d.etitle\">\u6297\u51dd\u4f5c\u7528<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u51dd\u8840\u7cfb\u7edf\u4e0e\u6297\u51dd\u3001\u7ea4\u6eb6\u7cfb\u7edf\u52a8\u6001\u76f8\u4e92\u4f5c\u7528\uff0c\u5728\u751f\u7406\u6b62\u8840\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u8fd9\u79cd\u76f8\u4e92\u4f5c\u7528\u4e5f\u53ef\u80fd\u662f\u591a\u79cd\u75be\u75c5\u7684\u5171\u540c\u70b9\uff0c\u5373\u5b83\u53ef\u80fd\u6709\u52a9\u4e8e\u5404\u79cd\u75be\u75c5\u7684\u75c5\u7406\u5b66\uff0c\u7279\u522b\u662f\u5fc3\u810f\u75c5\u3001\u764c\u75c7\u548c\u708e\u75c7\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B40\" aria-expanded=\"false\" aria-haspopup=\"true\">\u9a6c\u514b\u601d\uff0c1982<\/a>\uff09\u3002\u6709\u8bc1\u636e\u8868\u660e\uff0c\u706f\u76cf\u82b1\u7d20\u53ef\u4ee5\u6a21\u62df\u5185\u76ae\u7ec6\u80de\u7684\u7ea4\u6eb6\u548c\u6297\u51dd\u4f5c\u7528\uff0c\u8868\u73b0\u4e3a\u8bf1\u5bfc\u8840\u6813\u8c03\u8282\u86cb\u767d\uff08TM\uff09\u7684\u4ea7\u751f\u3001\u4e0b\u8c03\u7ec6\u80de\u8868\u9762TM\u7684\u8868\u8fbe\u4ee5\u53ca\u6291\u5236\u7ec6\u80de\u4e2dTM\u7684\u91ca\u653e\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B105\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5468\u7b49\u4eba\uff0c1992<\/a>\uff09\u3002\u6b64\u5916\uff0c\u53e6\u4e00\u9879\u7814\u7a76\u8868\u660e\u706f\u76cf\u82b1\u63d0\u53d6\u7269\u901a\u8fc7\u663e\u7740\u5ef6\u8fdf\u51dd\u8840\u65f6\u95f4\uff08CT\uff09\u548c\u51dd\u8840\u9176\u539f\u65f6\u95f4\uff08PT\uff09\u3001\u6291\u5236\u8840\u5c0f\u677f\u56e0\u5b50III\uff08PF3\uff09\u6d3b\u6027\u548c\u51cf\u5c11\u4f18\u7403\u86cb\u767d\u6eb6\u89e3\u65f6\u95f4\uff08ELT\uff09\u6765\u5f71\u54cd\u6297\u51dd\u4f5c\u7528\uff1b\u6b64\u5916\uff0c\u5b83\u8fd8\u53ef\u4ee5\u589e\u5f3a\u7ea4\u7ef4\u86cb\u767d\u6eb6\u89e3\u7684\u6d3b\u6027\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B80\" aria-expanded=\"false\" aria-haspopup=\"true\">\u738b\u7b49\u4eba\uff0c2003<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.d.f\" class=\"sec\">\n<h3 id=\"sec-a.l.d.ftitle\">\u6297\u8840\u6813\u4f5c\u7528<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u81f4\u75c5\u6027\u8840\u6813\u662f\u6025\u6027\u4e34\u5e8a\u52a8\u8109\u7ca5\u6837\u786c\u5316\u8840\u6813\u6027\u75be\u75c5\u7684\u539f\u56e0\uff0c\u4f8b\u5982\u6025\u6027\u51a0\u72b6\u52a8\u8109\u7efc\u5408\u5f81\u548c\u7f3a\u8840\u6027\u4e2d\u98ce\u3002\u6d3b\u5316\u7684\u8840\u5c0f\u677f\u5728\u81f4\u75c5\u6027\u8840\u6813\u7684\u5f62\u6210\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u5728\u8840\u5c0f\u677f\u6d3b\u5316\u8fc7\u7a0b\u4e2d\uff0c\u8840\u6813\u7d20A2\uff08TxA2\uff09\u3001\u4e8c\u78f7\u9178\u817a\u82f7\uff08ADP\uff09\u548c\u51dd\u8840\u9176\u7b49\u7279\u5f02\u6027\u6fc0\u52a8\u5242\u4e0e\u8840\u5c0f\u677f\u8868\u9762\u76f8\u5e94\u7684\u53d7\u4f53\u7ed3\u5408\u3002\u60a3\u6709\u52a8\u8109\u7ca5\u6837\u786c\u5316\u8840\u6813\u5f62\u6210\u7684\u60a3\u8005\u53d7\u76ca\u4e8e\u4f7f\u7528\u9488\u5bf9 TxA2\uff08\u963f\u53f8\u5339\u6797\uff09\u548c ADP\uff08P2Y12 \u6291\u5236\u5242\uff0c\u5982\u6c2f\u5421\u683c\u96f7\u3001\u567b\u6c2f\u5339\u5b9a\uff09\u8840\u5c0f\u677f\u6fc0\u6d3b\u9014\u5f84\u7684\u53e3\u670d\u6297\u8840\u5c0f\u677f\u836f\u7269\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B11\" aria-expanded=\"false\" aria-haspopup=\"true\">\u82ac\u7279\u5c14\uff0c2012<\/a>\uff09\u3002\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u00a0<em>\u706f\u76cf\u82b1<\/em>\u00a0\u9ec4\u916e\u80fd\u663e\u7740\u6291\u5236ADP\u3001\u82b1\u751f\u56db\u70ef\u9178\uff08AA\uff09\u548c\u8840\u5c0f\u677f\u6d3b\u5316\u56e0\u5b50\uff08PAF\uff09\u5f62\u6210\u8840\u6813\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B61\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6c89\u7b49\u4eba\uff0c2000<\/a>\uff09\u3002\u540c\u65f6\uff0c\u53e6\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u706f\u76cf\u82b1\u4e59\u7d20\u53ef\u901a\u8fc7\u5242\u91cf\u4f9d\u8d56\u7684\u65b9\u5f0f\u9650\u5236ADP\u8bf1\u5bfc\u7684\u5927\u9f20\u8840\u5c0f\u677f\u805a\u96c6\u7387\uff0c\u4ece\u800c\u9884\u9632\u8840\u6813\u5f62\u6210\u548c\u8840\u5c0f\u677f\u805a\u96c6\uff0c\u6539\u5584\u8840\u6db2\u6d41\u53d8\u5b66\u7279\u5f81\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B64\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5b8b\u7b49\uff0c2011<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.d.g\" class=\"sec\">\n<h3 id=\"sec-a.l.d.gtitle\">\u5185\u76ae\u4fdd\u62a4\u4f5c\u7528<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\uff08VEC\uff09\u5bf9\u4e8e\u5185\u5206\u6ccc\u7cfb\u7edf\u548c\u9776\u5668\u5b98\u5f88\u91cd\u8981\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B59\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8428\u52d2\u65af\u7b49\u4eba\uff0c2016<\/a>\uff09\u3002 VEC \u635f\u4f24\u53ef\u5f15\u8d77\u5404\u79cd\u8840\u7ba1\u529f\u80fd\u969c\u788d\uff0c\u901a\u5e38\u4f34\u6709\u5185\u76ae\u7ec6\u80de\u635f\u4f24\u3001\u6c27\u81ea\u7531\u57fa\u7684\u4ea7\u751f\u548c\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\u7684\u91ca\u653e\u3002\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u706f\u76cf\u7ec6\u8f9b\u6ce8\u5c04\u6db2\uff08\u4e3b\u8981\u6210\u5206\u4e3a\u706f\u76cf\u82b1\u7d20\uff09\u53ef\u901a\u8fc7\u6291\u5236\u708e\u75c7\u53cd\u5e94\uff0c\u51cf\u8f7bTNF-\u03b1\u5bf9\u5fc3\u810f\u5faeVEC\u7684\u635f\u4f24\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B94\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f20\u7b49\u4eba\uff0c2009<\/a>\uff09\u3002\u540c\u65f6\uff0c\u706f\u76cf\u82b1\u7d20\u88ab\u8bc1\u660e\u5bf9 ox-LDL \u8bf1\u5bfc\u7684\u5185\u76ae\u7ec6\u80de\u635f\u4f24\u5177\u6709\u4fdd\u62a4\u4f5c\u7528\uff0c\u8fd9\u53ef\u80fd\u4e0e\u5176\u6297\u6c27\u5316\u4f5c\u7528\u548c\u6291\u5236 NF-\u03baB \u6fc0\u6d3b\u6709\u5173\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B5\" aria-expanded=\"false\" aria-haspopup=\"true\">\u9648\u7b49\u4eba\uff0c2015<\/a>\uff09\u3002\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u662f\u751f\u7406\u548c\u75c5\u7406\u6027\u8840\u7ba1\u751f\u6210\u4e2d\u6700\u6709\u6548\u7684\u8840\u7ba1\u751f\u6210\u56e0\u5b50\uff0c\u5728\u635f\u4f24\u540e\u7684\u4fee\u590d\u8fc7\u7a0b\u4e2d\u53d1\u6325\u7740\u81f3\u5173\u91cd\u8981\u7684\u4e00\u6b65\u3002\u540c\u6837\uff0c\u53e6\u4e00\u9879\u7814\u7a76\u63d0\u793a\u706f\u76cf\u82b1\u4e59\u7d20\u5bf9\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u540e\u7684VEC\u5177\u6709\u4fdd\u62a4\u4f5c\u7528\uff0c\u5176\u673a\u5236\u53ef\u80fd\u4e0eVEGF\u7684\u65e9\u671f\u5347\u9ad8\u6709\u5173\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B31\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6797\u7b49\u4eba\uff0c2011<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.d.h\" class=\"sec\">\n<h3 id=\"sec-a.l.d.htitle\">\u5fc3\u808c\u4fdd\u62a4\u4f5c\u7528<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u5f53\u5fc3\u808c\u7ec6\u80de\u53d7\u5230\u5fc3\u810f\u624b\u672f\u3001\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u3001\u7cd6\u5c3f\u75c5\u635f\u4f24\u3001\u7f3a\u6c27\u635f\u4f24\u7b49\u75c5\u7406\u56e0\u7d20\u635f\u4f24\u65f6\uff0c\u5176\u75c5\u7406\u8fc7\u7a0b\u53ef\u80fd\u4ece\u6700\u521d\u7684\u7ec6\u80de\u6c34\u80bf\u3001\u53d8\u6027\u3001\u574f\u6b7b\u6f14\u53d8\u4e3a\u5fc3\u808c\u80a5\u539a\u548c\u5fc3\u808c\u7ea4\u7ef4\u5316\u3002\u6709\u51e0\u9879\u7814\u7a76\u9610\u660e\u4e86\u706f\u76cf\u82b1\u7d20\u7684\u6f5c\u5728\u5fc3\u808c\u4fdd\u62a4\u4f5c\u7528\u53ca\u5176\u673a\u5236\u3002\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u706f\u76cf\u82b1\u7d20\u901a\u8fc7\u663e\u7740\u51cf\u5c11 LDH \u6e17\u6f0f\u3001\u7ec6\u80de\u5185\u6e38\u79bb Ca<sup>2+<\/sup>\u00a0\u7f3a\u6c27\u65f6\u5fc3\u808c\u7ec6\u80de\u7684\u6c34\u5e73\u3001\u51cb\u4ea1\u548c\u574f\u6b7b\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B28\" aria-expanded=\"false\" aria-haspopup=\"true\">\u674e\u7b49\u4eba\uff0c2004<\/a>\uff09\u3002\u5728\u7cd6\u5c3f\u75c5\u635f\u4f24\u7684\u60c5\u51b5\u4e0b\uff0c\u706f\u76cf\u82b1\u7d20\u53ef\u80fd\u901a\u8fc7\u964d\u4f4e\u86cb\u767d\u6fc0\u9176C\uff08PKC\uff09\u548c\u53d7\u78f7\u86cb\u767d\uff08PLB\uff09\u7684\u8868\u8fbe\u4ee5\u53ca\u589e\u52a0\u86cb\u767d\u78f7\u9178\u9176\u6291\u5236\u5242-1\uff08PPI-1\uff09\u7684\u8868\u8fbe\u800c\u5bf9\u7cd6\u5c3f\u75c5\u5fc3\u808c\u75c5\u4ea7\u751f\u4fdd\u62a4\u4f5c\u7528\u3002 Ca(2+)-ATP \u9176 (SERCA-2) \u548c\u5170\u5c3c\u78b1\u53d7\u4f53 (RyR)\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B77\" aria-expanded=\"false\" aria-haspopup=\"true\">\u738b\u7b49\u4eba\uff0c2010<\/a>\uff09\u3002\u5728\u8840\u7ba1\u7d27\u5f20\u7d20 II (Ang II) \u8bf1\u5bfc\u7684\u5fc3\u810f\u80a5\u5927\u60c5\u51b5\u4e0b\uff0c\u7814\u7a76\u8868\u660e\u706f\u76cf\u82b1\u7d20\u53ef\u80fd\u4ecd\u5177\u6709\u901a\u8fc7\u7834\u574f\u5fc3\u808c\u7ec6\u80de\u4e2d PKC-\u03b1 \u4f9d\u8d56\u6027 ERK1\/2 \u548c PI3K\/AKT \u4fe1\u53f7\u4f20\u5bfc\u6765\u9884\u9632\u5fc3\u810f\u80a5\u5927\u7684\u6f5c\u529b\u00a0<em>\u4f53\u5916<\/em>\u00a0\u548c\u8001\u9f20\u00a0<em>\u4f53\u5185<\/em>\u00a0(<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B86\" aria-expanded=\"false\" aria-haspopup=\"true\">\u4e25\u7b49\u4eba\uff0c2010<\/a>\uff09\u3002\u53e6\u4e00\u9879\u7814\u7a76\u8fd8\u8868\u660e\uff0c\u706f\u76cf\u4e59\u7d20\u53ef\u4ee5\u901a\u8fc7\u6291\u5236\u5fc3\u810f\u5185\u76ae-\u95f4\u8d28\u8f6c\u5316\u6765\u9884\u9632\u5f02\u4e19\u80be\u4e0a\u817a\u7d20\u8bf1\u5bfc\u7684\u5fc3\u808c\u7ea4\u7ef4\u5316\uff0c\u8fd9\u53ef\u80fd\u4e0eNotch\u901a\u8def\u6709\u5173\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B104\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5468\u7b49\uff0c2014<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.d.i\" class=\"sec\">\n<h3 id=\"sec-a.l.d.ititle\">\u51cf\u5c11\u5e73\u6ed1\u808c\u7ec6\u80de\u8fc1\u79fb\u548c\u589e\u6b96<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de\uff08VSMC\uff09\u8fc1\u79fb\u548c\u589e\u6b96\u662f\u52a8\u8109\u7ca5\u6837\u786c\u5316\u53d1\u5c55\u7684\u4e3b\u8981\u75c5\u7406\u751f\u7406\u6b65\u9aa4\u3002\u6b64\u5916\uff0c\u8c03\u8282 VSMC \u589e\u6b96\u53ef\u80fd\u5bf9\u8840\u7ba1\u75be\u75c5\u5177\u6709\u6cbb\u7597\u4f5c\u7528\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B56\" aria-expanded=\"false\" aria-haspopup=\"true\">\u7f57\u65af\uff0c1993<\/a>\uff09\u3002\u51dd\u8840\u9176\u5df2\u88ab\u8bc1\u660e\u53ef\u8bf1\u5bfc VSMC \u589e\u6b96\u3002\u51dd\u8840\u9176\u53d7\u4f53\u5b58\u5728\u4e8e\u6240\u6709\u5bf9\u51dd\u8840\u9176\u6709\u53cd\u5e94\u7684\u7ec6\u80de\u7c7b\u578b\u4e2d\uff0c\u5305\u62ec\u8840\u5c0f\u677f\u3001\u5185\u76ae\u7ec6\u80de\u548c\u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de\u3002\u6b64\u5916\uff0c\u51dd\u8840\u9176\u53d7\u4f53\u62ee\u6297\u5242\u53ef\u7528\u4f5c\u6cbb\u7597\u5242\uff0c\u901a\u8fc7\u7279\u5f02\u6027\u6291\u5236\u7ec6\u80de\u589e\u6b96\u800c\u5177\u6709\u4ef7\u503c\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B48\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5e15\u5361\u62c9\u7b49\u4eba\uff0c2001<\/a>\uff09\u3002\u6709\u7814\u7a76\u8868\u660e\u706f\u76cf\u82b1\u7d20\u80fd\u663e\u7740\u6291\u5236\u5927\u9f20\u4e3b\u52a8\u8109\u5e73\u6ed1\u808c\u7ec6\u80de\u589e\u6b96\u8bf1\u5bfc\u51dd\u8840\u9176\u3002\u53ef\u80fd\u7684\u673a\u5236\u662f\u963b\u65ad\u51dd\u8840\u9176\u53d7\u4f53\u57fa\u56e0\u7684\u8868\u8fbe\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B22\" aria-expanded=\"false\" aria-haspopup=\"true\">\u4faf\u7b49\u4eba\uff0c2009<\/a>\uff09\u3002\u6b64\u5916\uff0c\u706f\u76cf\u82b1\u7d20\u80fd\u660e\u663e\u6291\u5236VSMC\u589e\u6b96\uff0c\u53ef\u80fd\u9884\u9632\u52a8\u8109\u7ca5\u6837\u786c\u5316\uff0c\u5176\u673a\u5236\u53ef\u80fd\u90e8\u5206\u662f\u901a\u8fc7\u8c03\u8282VSMC NF-\u03baB\u6d3b\u6027\u6765\u5b9e\u73b0\u7684\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B49\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5e9e\u7b49\u4eba\uff0c2004<\/a>\uff09\u3002\u6b64\u5916\uff0c\u706f\u76cf\u82b1\u7d20\u53ef\u4ee5\u901a\u8fc7\u6291\u5236 ERK1\/2 MAPK \u4fe1\u53f7\u4f20\u5bfc\u6765\u6539\u5584\u9ad8\u8461\u8404\u7cd6\u8bf1\u5bfc\u7684 VSMC \u589e\u6b96\u548c\u8fc1\u79fb\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B21\" aria-expanded=\"false\" aria-haspopup=\"true\">\u4ed6\u7b49\u4eba\uff0c2012<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.d.j\" class=\"sec\">\n<h3 id=\"sec-a.l.d.jtitle\">\u6297\u5fc3\u810f\u91cd\u6784\u4f5c\u7528<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u5fc3\u5ba4\u91cd\u6784\u662f\u75c5\u7406\u4fee\u590d\u3001\u5fc3\u5ba4\u4ee3\u507f\u548c\u7ee7\u53d1\u6027\u75c5\u7406\u751f\u7406\u53cd\u5e94\u7684\u8fc7\u7a0b\uff0c\u4f34\u968f\u7740\u5fc3\u5ba4\u5fc3\u808c\u635f\u4f24\u76f8\u5173\u7684\u4e00\u7cfb\u5217\u5927\u5c0f\u3001\u5f62\u72b6\u3001\u58c1\u539a\u548c\u7ec4\u7ec7\u7ed3\u6784\u7b49\u53c2\u6570\u7684\u53d8\u5316\u3002\u4e00\u9879\u7814\u7a76\u8868\u660e\u706f\u76cf\u82b1\u7d20\u53ef\u4ee5\u901a\u8fc7\u6539\u5584\u5fc3\u808c\u6536\u7f29\u548c\u8212\u5f20\u529f\u80fd\u6765\u8c03\u8282\u5fc3\u529b\u8870\u7aed\u52a8\u7269\u7684\u5fc3\u5ba4\u91cd\u6784\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B30\" aria-expanded=\"false\" aria-haspopup=\"true\">\u674e\uff0c2011<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.d.k\" class=\"sec\">\n<h3 id=\"sec-a.l.d.ktitle\">\u6297\u5fc3\u5f8b\u5931\u5e38\u4f5c\u7528<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u706f\u76cf\u82b1\u7d20\u5df2\u88ab\u8bc1\u660e\u53ef\u4ee5\u5bf9\u5154\u5fc3\u810f\u548c\u5927\u9f20\u5fc3\u5ba4\u808c\u7ec6\u80de\u4ea7\u751f\u67d0\u4e9b\u7279\u5b9a\u7684\u6297\u5fc3\u5f8b\u5931\u5e38\u4f5c\u7528\uff0c\u5c3d\u7ba1\u5176\u4f5c\u7528\u80cc\u540e\u7684\u6f5c\u5728\u673a\u5236\u5c1a\u4e0d\u6e05\u695a\uff0c\u5e76\u4e14\u4ecd\u5728\u7814\u7a76\u4e2d\u3002\u4e00\u9879\u7814\u7a76\u8868\u660e\u706f\u76cf\u82b1\u7d20\u53ef\u4ee5\u51cf\u5c11\u8de8\u58c1\u590d\u6781\u8272\u6563\uff08TDR\uff09\u5e76\u964d\u4f4e\u9664\u6781\u65e9\u671f\uff08EAD\uff09\u548c\u5c16\u7aef\u626d\u8f6c\u578b\u5ba4\u901f\uff08Tdp\uff09\u7684\u53d1\u751f\u7387\uff0c\u4ece\u800c\u964d\u4f4e\u80a5\u539a\u5154\u5fc3\u810f\u7684\u5ba4\u6027\u5fc3\u5f8b\u5931\u5e38\u7684\u53d1\u751f\u7387\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B1\" aria-expanded=\"false\" aria-haspopup=\"true\">\u535a\u7b49\u4eba\uff0c2011<\/a>\uff09\u3002\u5df2\u7ecf\u8bc1\u660e\uff0c\u5fc3\u810f\u7535\u6d3b\u52a8\u4f9d\u8d56\u4e8e\u5fc3\u810f\u7ec6\u80de\u819c\u4e0a\u7684\u79bb\u5b50\u901a\u9053\u7684\u751f\u7406\u529f\u80fd\u3002\u7136\u540e\uff0c\u4eba\u4eec\u62c5\u5fc3\u4f1a\u5f71\u54cd\u5fc3\u5ba4\u808c\u7ec6\u80de\u4e2d\u7684\u94be\u548c\u94a0\u7535\u6d41\u3002\u636e\u89c2\u5bdf\uff0c\u706f\u76cf\u82b1\u7d20\u53ef\u4ee5\u6291\u5236\u94be\u7535\u6d41\uff08I<sub>\u5230<\/sub>\uff09\u4ee5\u6d53\u5ea6\u548c\u7535\u538b\u4f9d\u8d56\u6027\u65b9\u5f0f\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B6\" aria-expanded=\"false\" aria-haspopup=\"true\">\u9093\u7b49\uff0c2008<\/a>\uff09 \u548c\u6211<sub>\u94a0<\/sub>\u00a0\u901a\u9053\u7535\u6d41\u4ee5\u6d53\u5ea6\u4f9d\u8d56\u6027\u65b9\u5f0f\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B65\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5510\u7b49\u4eba\uff0c2009<\/a>\uff09\uff0c\u8fd9\u53ef\u80fd\u662f\u5176\u6297\u5fc3\u5f8b\u5931\u5e38\u4f5c\u7528\u7684\u91cd\u8981\u673a\u5236\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.d.l\" class=\"sec\">\n<h3 id=\"sec-a.l.d.ltitle\">\u964d\u8102\u4f5c\u7528<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u964d\u8102\u662fCVD\u7684\u5e38\u89c4\u6cbb\u7597\u65b9\u6cd5\u3002\u4e00\u4e9b\u4e34\u5e8a\u7814\u7a76\u8868\u660e\u706f\u76cf\u82b1\u7d20\u53ef\u4ee5\u964d\u4f4e\u8840\u8102\u3002\u7136\u800c\uff0c\u52a8\u7269\u5b9e\u9a8c\u5374\u5f97\u5230\u4e86\u4e0d\u540c\u7684\u7ed3\u679c\u3002\u4e00\u9879\u7814\u7a76\u8868\u660e\u706f\u76cf\u82b1\u7d20\u53ef\u4ee5\u964d\u4f4e\u7cd6\u5c3f\u75c5\u5927\u9f20\u7684\u8840\u8102\u6c34\u5e73\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B81\" aria-expanded=\"false\" aria-haspopup=\"true\">\u9b4f\u7b49\u4eba\uff0c2010<\/a>\uff09\u3002\u53e6\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u5b83\u53ef\u4ee5\u6291\u5236\u5185\u819c\u589e\u751f\u548c\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u8fdb\u5c55\uff0c\u4f46\u4e0d\u80fd\u964d\u4f4e\u8840\u6e05\u80c6\u56fa\u9187\u6c34\u5e73\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B37\" aria-expanded=\"false\" aria-haspopup=\"true\">\u697c\u548c\u5218\uff0c2009<\/a>\uff09\u3002\u6b64\u5916\uff0c\u5c1a\u65e0\u7814\u7a76\u89e3\u91ca\u5176\u964d\u8102\u4f5c\u7528\u7684\u673a\u5236\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.d.m\" class=\"sec sec-last\">\n<h3 id=\"sec-a.l.d.mtitle\">\u6539\u5584\u52c3\u8d77\u529f\u80fd\u969c\u788d<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u52c3\u8d77\u53cd\u5e94\u53d7\u635f\u662f\u539f\u53d1\u6027\u9ad8\u8840\u538b\u7684\u6f5c\u5728\u5e76\u53d1\u75c7\u4e4b\u4e00\u3002\u6b63\u5982 2013 \u5e74 ESH\/ESC \u52a8\u8109\u9ad8\u8840\u538b\u7ba1\u7406\u6307\u5357\u4e2d\u63d0\u5230\u7684\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B9\" aria-expanded=\"false\" aria-haspopup=\"true\">ESH\/ESC \u52a8\u8109\u9ad8\u8840\u538b\u7ba1\u7406\u5de5\u4f5c\u7ec4\uff0c2013 \u5e74<\/a>\uff09\uff0c\u52c3\u8d77\u529f\u80fd\u969c\u788d\u53ef\u88ab\u89c6\u4e3a\u72ec\u7acb\u7684\u5fc3\u8840\u7ba1\u5371\u9669\u56e0\u7d20\u548c\u4e34\u5e8a\u5668\u5b98\u635f\u5bb3\u7684\u65e9\u671f\u8bca\u65ad\u6307\u6807\u3002\u56e0\u6b64\uff0c\u4eba\u4eec\u4e00\u76f4\u81f4\u529b\u4e8e\u7814\u7a76\u706f\u76cf\u82b1\u7d20\u662f\u5426\u53ef\u4ee5\u9006\u8f6c\u9ad8\u8840\u538b\u5f15\u8d77\u7684\u52c3\u8d77\u529f\u80fd\u969c\u788d\u3002\u7ed3\u8bba\u662f\uff0c\u81ea\u53d1\u6027\u9ad8\u8840\u538b\u5927\u9f20 (SHR) \u7684\u52c3\u8d77\u53cd\u5e94\u53d7\u635f\u53ef\u80fd\u662f\u7531 RhoA\/Rho \u6fc0\u9176\u4fe1\u53f7\u4f20\u5bfc\u589e\u52a0\u548c\u4e00\u6c27\u5316\u6c2e (NO) \u4fe1\u53f7\u4f20\u5bfc\u51cf\u5c11\u5f15\u8d77\u7684\u3002\u4e00\u9879\u7814\u7a76\u8868\u660e\u706f\u76cf\u82b1\u7d20\u53ef\u4ee5\u901a\u8fc7\u4e0b\u8c03 RhoA\/Rho \u6fc0\u9176\u9014\u5f84\u6765\u6539\u5584\u52c3\u8d77\u529f\u80fd\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B29\" aria-expanded=\"false\" aria-haspopup=\"true\">\u674e\u7b49\u4eba\uff0c2014<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<div id=\"sec-a.l.e\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"sec-a.l.etitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u706f\u76cf\u82b1\u7d20\u6cbb\u7597\u4e34\u5e8a\u5fc3\u8840\u7ba1\u75be\u75c5<\/h2>\n<p>&nbsp;<\/p>\n<p class=\"p p-first\">\u5fc3\u8840\u7ba1\u75be\u75c5\u4ecd\u7136\u662f\u5168\u4e16\u754c\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u3002 2008 \u5e74\u5168\u7403\u6b7b\u4ea1\u4eba\u6570\u4e3a 5700 \u4e07\u4eba\uff0c\u5176\u4e2d\u8d85\u8fc7 1730 \u4e07\u4eba (30%) \u6b7b\u4e8e\u5fc3\u8840\u7ba1\u75be\u75c5\u3002\u5c3d\u7ba1\u8fc7\u53bb20\u5e74\u8bb8\u591a\u9ad8\u6536\u5165\u56fd\u5bb6\u7684\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u7387\u6709\u6240\u4e0b\u964d\uff0c\u4f46\u7531\u4e8e\u7f3a\u4e4f\u5168\u6c11\u521d\u7ea7\u9884\u9632\u548c\u4e2a\u4eba\u533b\u7597\u4fdd\u5065\u5e72\u9884\uff0c\u4f4e\u6536\u5165\u548c\u4e2d\u7b49\u6536\u5165\u56fd\u5bb6\u7684\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u7387\u5374\u8fc5\u901f\u4e0a\u5347\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B43\" aria-expanded=\"false\" aria-haspopup=\"true\">\u95e8\u8fea\u65af\u7b49\u4eba\uff0c2011<\/a>\uff09\u3002\u706f\u76cf\u82b1\u7d20\u56e0\u5176\u5177\u6709\u8212\u5f20\u8840\u7ba1\u3001\u4fdd\u62a4\u5fc3\u808c\u3001\u6297\u5fc3\u5f8b\u5931\u5e38\u3001\u964d\u4f4e\u52a8\u8109\u8840\u538b\u7b49\u4f5c\u7528\uff0c\u5728\u6211\u56fd\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u9884\u9632\uff0c\u5927\u91cf\u7814\u7a76\u63d0\u4f9b\u4e86\u8bc1\u636e\u652f\u6301\u8fd9\u4e9b\u6709\u5229\u4f5c\u7528\uff1b\u7136\u800c\uff0c\u4e00\u4e9b\u7814\u7a76\u4e5f\u62a5\u544a\u4e86\u5fc3\u8840\u7ba1\u75be\u75c5\u4e2d\u53d1\u751f\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u4f8b\u5982\u76ae\u75b9\u3001\u8fc7\u654f\u6027\u4f11\u514b\u3001\u5fc3\u623f\u98a4\u52a8 (AF) \u548c\u8179\u6cfb\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B35\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5218\u548c\u767d\uff0c2012<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B97\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f20\u7b49\uff0c2016<\/a>\uff09\u3002\u672c\u6587\u4e25\u683c\u5ba1\u67e5\u4e86\u62a5\u9053\u706f\u76cf\u82b1\u7d20\u5bf9\u5fc3\u8840\u7ba1\u75be\u75c5 [\u51a0\u5fc3\u75c5 (CHD)\u3001MI\u3001\u9ad8\u8840\u538b\u3001\u5fc3\u5f8b\u5931\u5e38\u7b49] \u5f71\u54cd\u7684\u79d1\u5b66\u6587\u732e\u3002\u6839\u636e\u672c\u6b21\u8bc4\u4ef7\u7684\u65b9\u6cd5\uff0c\u672c\u6b21\u8bc4\u4ef7\u7eb3\u5165\u4e86 19 \u9879\u8bd5\u9a8c\uff0c\u5176\u4e2d 2 \u9879\u5173\u4e8e CHD \u7684\u8bd5\u9a8c\uff0c3 \u9879\u5173\u4e8e MI \u7684\u8bd5\u9a8c\uff0c2 \u9879\u5173\u4e8e\u9ad8\u8840\u538b\u7684\u8bd5\u9a8c\uff0c1 \u9879\u5173\u4e8e\u5fc3\u5f8b\u5931\u5e38\u7684\u8bd5\u9a8c\uff0c3 \u9879\u5173\u4e8e\u9ad8\u8102\u8840\u75c7\u7684\u8bd5\u9a8c\uff0c2 \u9879\u5173\u4e8e\u75c5\u6bd2\u6027\u7684\u8bd5\u9a8c\u3002\u5fc3\u808c\u708e (VMC)\u3001\u6162\u6027\u5fc3\u529b\u8870\u7aed (CHF) \u7684 3 \u9879\u8bd5\u9a8c\u548c\u80ba\u5fc3\u75c5 (PHD) \u7684 3 \u9879\u8bd5\u9a8c\uff08\u89c1\u00a0<strong>\u684c\u5b50\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/table\/T2\/\" target=\"table\" rel=\"noopener\">\u200b<span class=\"figpopup-sensitive-area\">\u88682<\/span>2<\/a><\/strong>).<\/p>\n<p>&nbsp;<\/p>\n<div id=\"sec-a.l.e.c\" class=\"sec\">\n<h3 id=\"sec-a.l.e.ctitle\">\u51a0\u72b6\u52a8\u8109\u5fc3\u810f\u75be\u75c5<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first\">\u51a0\u5fc3\u75c5\u662f\u6700\u5e38\u89c1\u7684CVD\u7c7b\u578b\uff0c\u4e5f\u662f\u81f4\u547d\u75be\u75c5\u4e4b\u4e00\u3002\u6700\u65b0\u6570\u636e\u663e\u793a\uff0c2013\u5e74\uff0c\u51a0\u5fc3\u75c5\u5bfc\u81f4814\u4e07\u4eba\u6b7b\u4ea1\uff0c\u5360\u5168\u7403\u603b\u6b7b\u4ea1\u4eba\u6570\u768416.8%\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B14\" aria-expanded=\"false\" aria-haspopup=\"true\">GBD 2013 \u6b7b\u4ea1\u7387\u548c\u6b7b\u56e0\u5408\u4f5c\u8005\uff0c2015 \u5e74<\/a>\uff09\u3002\u76ee\u524d\uff0c\u901a\u8fc7\u6539\u53d8\u751f\u6d3b\u65b9\u5f0f\uff0c\u5982\u953b\u70bc\u8eab\u4f53\u3001\u5065\u5eb7\u996e\u98df\u3001\u6cbb\u7597\u9ad8\u8840\u538b\u4ee5\u53ca\u836f\u7269\u6cbb\u7597\uff0c\u5305\u62ec\u6297\u8840\u5c0f\u677f\u836f\u7269\u5982\u963f\u53f8\u5339\u6797\u3001\u785d\u5316\u7518\u6cb9\u3001\u03b2\u53d7\u4f53\u963b\u6ede\u5242\u548c\u4ed6\u6c40\u7c7b\u836f\u7269\uff0c\u51a0\u5fc3\u75c5\u7684\u53d1\u75c5\u7387\u5df2\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u964d\u4f4e\u3002 \u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u836f\u7269\u4e5f\u6709\u4e00\u4e9b\u4e0d\u53ef\u907f\u514d\u7684\u526f\u4f5c\u7528\u3002\u706f\u76cf\u82b1\u7d20\u662f\u4e00\u79cd\u8865\u5145\u836f\u7269\uff0c\u5728\u4e2d\u56fd\u51e0\u5341\u5e74\u6765\u4e00\u76f4\u4e0e\u5e38\u89c4\u836f\u7269\u8054\u5408\u7528\u4e8e\u9884\u9632\u548c\u6cbb\u7597\u51a0\u5fc3\u75c5\u3002\u5b83\u63d0\u4f9b\u4e86\u5f88\u591a\u597d\u5904\uff1b\u4f8b\u5982\uff0c\u4e0e\u5355\u72ec\u7684\u5e38\u89c4\u6cbb\u7597\u76f8\u6bd4\uff0c\u5b83\u63d0\u9ad8\u4e86\u6cbb\u7597\u6548\u679c\uff0c\u5e76\u4e14\u6709\u52a9\u4e8e\u51cf\u5c11\u53ef\u80fd\u5f15\u8d77\u4e0d\u826f\u53cd\u5e94\u7684\u51e0\u79cd\u836f\u7269\u7684\u5242\u91cf\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B71\" aria-expanded=\"false\" aria-haspopup=\"true\">\u738b\u6210\u7b49\uff0c2015<\/a>\uff09\u3002\u5df2\u7ecf\u8fdb\u884c\u4e86\u5927\u91cf\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u6765\u63a2\u8ba8\u706f\u76cf\u82b1\u7d20\u5bf9\u51a0\u5fc3\u75c5\u7684\u4f5c\u7528\u3002<\/p>\n<p class=\"p p-last\">\u5728\u4e00\u9879\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u4e2d\uff0c50 \u540d\u7a33\u5b9a\u578b\u5fc3\u7ede\u75db\u60a3\u8005\u88ab\u968f\u673a\u5206\u4e3a\u4e24\u7ec4\uff0c\u63a5\u53d7\u706f\u76cf\u82b1\u7d20\uff0840 mg\/250 ml 0.9% \u6c2f\u5316\u94a0\uff0c\u9759\u8109\u6ef4\u6ce8\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u8054\u5408\u6807\u51c6\u836f\u7269\u6cbb\u7597\uff08<em>n<\/em>\u00a0= 25) \u6216\u5355\u72ec\u4f7f\u7528\u6807\u51c6\u836f\u7269 (<em>n<\/em>\u00a0= 25) 14 \u5929\u3002\u7ed3\u679c\u663e\u793a\uff0c\u8bd5\u9a8c\u7ec4\u5fc3\u7ede\u75db\u75c7\u72b6\u3001\u5fc3\u7535\u56feST-T\u53d8\u5316\u3001\u52a8\u6001\u5fc3\u7535\u56feST-T\u53d8\u5316\u65f6\u95f4\u5747\u8f83\u5bf9\u7167\u7ec4\u6709\u6539\u5584\u3002\u6b64\u5916\uff0c\u8bd5\u9a8c\u7ec4\u7684\u8840\u6db2\u6d41\u53d8\u5b66\u6307\u6807\uff0c\u5982\u5168\u8840\u7c98\u5ea6\uff08WBV\uff09\u3001\u8840\u6d46\u7c98\u5ea6\uff08PV\uff09\u3001\u7ea4\u7ef4\u86cb\u767d\u539f\uff08FIB\uff09\u548c\u8840\u8102\u7684\u6539\u5584\u5747\u8f83\u5bf9\u7167\u7ec4\u66f4\u4e3a\u663e\u7740\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B95\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f20\u548c\u5f20\uff0c2012<\/a>\uff09\u3002\u540c\u6837\uff0c\u8fdb\u884c\u4e86\u53e6\u4e00\u9879\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff0c\u6d4b\u8bd5\u706f\u76cf\u82b1\u7d20\u5bf9\u4e0d\u7a33\u5b9a\u5fc3\u7ede\u75db\u60a3\u8005\u7684\u7597\u6548\uff0c\u8fd9\u4e9b\u60a3\u8005\u88ab\u968f\u673a\u5206\u914d\u5728\u5e38\u89c4\u897f\u836f\u57fa\u7840\u4e0a\u6bcf\u5929\u63a5\u53d7 20 \u6beb\u5347\u706f\u76cf\u82b1\u7d20\u6cbb\u7597\uff08<em>n<\/em>\u00a0= 53\uff09\u6216\u5355\u72ec\u4f7f\u7528\u4f20\u7edf\u897f\u533b\uff08<em>n<\/em>\u00a0= 51) \u4e24\u5468\u3002\u7ed3\u679c\u8868\u660e\uff0c\u8bd5\u9a8c\u7ec4\u785d\u9178\u5f02\u5c71\u68a8\u916f\u7684\u7528\u91cf\u4f4e\u4e8e\u5bf9\u7167\u7ec4\uff0c\u4e14\u8bd5\u9a8c\u7ec4\u5bf9\u5fc3\u7535\u56fe\u7684\u7597\u6548\u8f83\u597d\u3002\u6b64\u5916\uff0c\u8bd5\u9a8c\u7ec4\u7684\u5168\u8840\u9ad8\u7c98\u5ea6\uff08WBHV\uff09\u3001PV\u3001\u7ea2\u7ec6\u80de\u805a\u96c6\u6307\u6570\u3001FIB\u3001hs-CRP\u4e5f\u4f4e\u4e8e\u5bf9\u7167\u7ec4\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u7814\u7a76\u4eba\u5458\u5e76\u672a\u53d1\u73b0\u4e24\u7ec4\u4e4b\u95f4\u7684\u5168\u8840\u4f4e\u526a\u5207\u7c98\u5ea6\u548c\u7ea2\u7ec6\u80de\u521a\u6027\u6307\u6570\u5b58\u5728\u663e\u7740\u5dee\u5f02\u3002\u6b64\u5916\uff0c\u672c\u7814\u7a76\u62a5\u544a\u5bf9\u7167\u7ec4\u6709 4 \u4f8b\u6076\u5fc3\u548c 1 \u4f8b\u5fc3\u60b8\uff0c\u8bd5\u9a8c\u7ec4\u6709 3 \u4f8b\u6076\u5fc3\u548c 2 \u4f8b\u8179\u80c0\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B60\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6c89\u7b49\u4eba\uff0c2014<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.e.d\" class=\"sec\">\n<h3 id=\"sec-a.l.e.dtitle\">\u5fc3\u808c\u6897\u585e (MI)<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">MI\uff0c\u4e5f\u79f0\u4e3a\u6025\u6027\u5fc3\u808c\u6897\u585e\uff08AMI\uff09\uff0c\u662f\u7531\u4e8e\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u7834\u88c2\u5f62\u6210\u8840\u6813\uff0c\u5bfc\u81f4\u6d41\u5411\u5fc3\u810f\u7684\u8840\u6d41\u53d7\u963b\u800c\u5f15\u8d77\u7684\u5fc3\u810f\u75c5\u53d1\u4f5c\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B43\" aria-expanded=\"false\" aria-haspopup=\"true\">\u95e8\u8fea\u65af\u7b49\u4eba\uff0c2011<\/a>\uff09\u3002\u4e00\u9879\u7814\u7a76\u62a5\u544a\u79f0\uff0c1990 \u5e74\u81f3 2010 \u5e74\u95f4\uff0c\u5168\u7403\u5fc3\u6897\u53d1\u751f\u7387\u6709\u6240\u4e0b\u964d\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B14\" aria-expanded=\"false\" aria-haspopup=\"true\">GBD 2013 \u6b7b\u4ea1\u7387\u548c\u6b7b\u56e0\u5408\u4f5c\u8005\uff0c2015 \u5e74<\/a>\uff09\u3002\u5c3d\u7ba1\u901a\u8fc7\u65e9\u671f\u6709\u6548\u7684\u9884\u9632\u63aa\u65bd\u548c\u5e72\u9884\u63aa\u65bd\uff0c\u5fc3\u808c\u6897\u6b7b\u7684\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u5df2\u5f97\u5230\u8f83\u5927\u7a0b\u5ea6\u7684\u63a7\u5236\uff0c\u4f46\u5fc3\u808c\u6897\u6b7b\u60a3\u8005\u7684\u4e8c\u7ea7\u9884\u9632\u548c\u5eb7\u590d\u4ecd\u5b58\u5728\u4e00\u4e9b\u95ee\u9898\u3002\u4e2d\u533b\uff08CM\uff09\u5728\u8fd9\u4e9b\u65b9\u9762\u663e\u793a\u51fa\u4e00\u4e9b\u4f18\u52bf\uff0c\u4f8b\u5982\u6539\u5584\u751f\u6d3b\u8d28\u91cf\uff08QOL\uff09\u548c\u964d\u4f4e\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B85\" aria-expanded=\"false\" aria-haspopup=\"true\">\u65ed\u5cf0\u7b49\uff0c2010<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B7\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6bb5\u7b49\uff0c2012<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B98\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f20\u7389\u534e, 2014<\/a>\uff09\u3002\u706f\u76cf\u82b1\u7d20\u7684\u51e0\u9879\u4e34\u5e8a\u7814\u7a76\u62a5\u544a\u4e86\u5176\u5bf9\u5fc3\u808c\u6897\u6b7b\u7684\u5f71\u54cd\u3002\u4e00\u9879\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u65e8\u5728\u89c2\u5bdf\u706f\u76cf\u82b1\u7d20\u5bf9\u63a5\u53d7\u706f\u76cf\u82b1\u7d20\uff0860 mg\/d\uff09\u548c\u5e38\u89c4\u6cbb\u7597\u7684 AMI \u60a3\u8005\u7684\u7597\u6548\uff08<em>n<\/em>\u00a0= 25\uff09\u6216\u5355\u72ec\u8fdb\u884c\u5e38\u89c4\u6cbb\u7597\uff08<em>n<\/em>\u00a0= 20) \u4e3a\u671f 10 \u5929\u3002\u8054\u5408\u7ec4\u60a3\u8005\u7684\u5de6\u5fc3\u5ba4\u5c04\u8840\u5206\u6570\uff08LVEF\uff09\u3001\u5916\u5468\u8840\u7ba1\u963b\u529b\u548c\u540e\u5fc3\u7ede\u75db\u53d1\u751f\u7387\u4e0e\u5bf9\u7167\u7ec4\u60a3\u8005\u76f8\u6bd4\u6709\u663e\u7740\u5dee\u5f02\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B18\" aria-expanded=\"false\" aria-haspopup=\"true\">\u987eTB\u7b49\uff0c2002<\/a>\uff09\u3002\u540c\u6837\uff0c\u53e6\u4e00\u9879\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u9488\u5bf9 60 \u540d\u7ecf\u76ae\u51a0\u72b6\u52a8\u8109\u4ecb\u5165\u6cbb\u7597 (PCI) \u540e\u63a5\u53d7\u5e38\u89c4\u836f\u7269\u548c\u706f\u76cf\u82b1\u7d20\u6ce8\u5c04\u6cbb\u7597\u7684\u60a3\u8005\u8fdb\u884c\u3002\u7ed3\u679c\u663e\u793a\uff0c\u8bd5\u9a8c\u7ec4\u5fc3\u529f\u80fd\u5206\u7ea7\u2264NYHA\u529f\u80fd\u5206\u7ea7II\u7ea7\u7684\u6bd4\u4f8b\uff0888.3%\uff09\u9ad8\u4e8e\u5bf9\u7167\u7ec4\uff0861.7%\uff09\u3002\u6b64\u5916\uff0c\u4e0e\u5bf9\u7167\u7ec4\uff0821.7%\uff09\u76f8\u6bd4\uff0c\u8bd5\u9a8c\u7ec4\uff086.7%\uff09\u5fc3\u810f\u4e0d\u826f\u4e8b\u4ef6\uff08MI\u3001\u5fc3\u5f8b\u5931\u5e38\u3001\u6b7b\u4ea1\uff09\u7684\u53d1\u751f\u7387\u8f83\u4f4e\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B87\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6768\u548c\u9648\uff0c2013<\/a>\uff09\u3002\u53e6\u4e00\u9879\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u65e8\u5728\u89c2\u5bdf\u706f\u76cf\u82b1\u7d20\u5bf9\u63a5\u53d7\u6210\u529f\u9759\u8109\u6eb6\u6813\u6cbb\u7597\u7684 AMI \u60a3\u8005\u8fd0\u52a8\u8010\u91cf\u7684\u5f71\u54cd\u3002 98 \u540d\u60a3\u8005\u88ab\u968f\u673a\u5206\u914d\u63a5\u53d7\u706f\u76cf\u82b1\u7d20\u8054\u5408\u5e38\u89c4\u6cbb\u7597\u6216\u5355\u72ec\u5e38\u89c4\u6cbb\u7597 14 \u5929\u3002\u5e73\u677f\u8fd0\u52a8\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u7b2c36\u5929\uff0c\u8054\u5408\u7ec4\u8f83\u5bf9\u7167\u7ec4\u8fd0\u52a8\u8bf1\u53d1\u5fc3\u7535\u56feST\u6bb5\u538b\u4f4e\u7684\u65f6\u95f4\u663e\u7740\u5ef6\u957f\uff08\u22650.1 mV\uff09\uff0c\u4e14ST\u6bb5\u538b\u4f4e\u7684\u6301\u7eed\u65f6\u95f4\u660e\u663e\u7f29\u77ed\u3002 \u3002\u7136\u800c\uff0c\u7b2c14\u5929\u6ca1\u6709\u663e\u7740\u5dee\u5f02\u3002\u8fd9\u610f\u5473\u7740\u706f\u76cf\u82b1\u7d20\u53ef\u80fd\u5177\u6709\u6301\u7eed\u4f5c\u7528\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B76\" aria-expanded=\"false\" aria-haspopup=\"true\">\u738b\u7b49\u4eba\uff0c2009<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.e.e\" class=\"sec\">\n<h3 id=\"sec-a.l.e.etitle\">\u9ad8\u8840\u538b<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u9ad8\u8840\u538b\u6bcf\u5e74\u5bfc\u81f4 780 \u4e07\u4eba\u6b7b\u4ea1\uff0c\u5360\u5168\u7403\u6b7b\u4ea1\u603b\u4eba\u6570\u7684 12.8%\u3002 1980 \u5e74\u81f3 2008 \u5e74\u95f4\uff0c\u8840\u538b\u4e0d\u53d7\u63a7\u5236\u7684\u4eba\u53e3\u89c4\u6a21\u5df2\u4ece 600 \u4e07\u589e\u52a0\u5230\u8fd1 10 \u4ebf\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B43\" aria-expanded=\"false\" aria-haspopup=\"true\">\u95e8\u8fea\u65af\u7b49\u4eba\uff0c2011<\/a>\uff09\u3002\u8840\u538b\u4e0d\u53d7\u63a7\u5236\u4e0d\u4ec5\u662f\u5bfc\u81f4\u51a0\u5fc3\u75c5\u548c\u4e2d\u98ce\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u4e5f\u662f\u5bfc\u81f4\u5fc3\u529b\u8870\u7aed\u3001\u6162\u6027\u80be\u75c5\u7b49\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B52\" aria-expanded=\"false\" aria-haspopup=\"true\">\u4fdd\u5c14\u7279\u7b49\u4eba\uff0c2015<\/a>\uff09\u3002\u5728\u4e1c\u65b9\u548c\u897f\u65b9\u56fd\u5bb6\uff0c\u8349\u836f\u4e0e\u6297\u9ad8\u8840\u538b\u836f\u7269\u76f8\u7ed3\u5408\u8d8a\u6765\u8d8a\u591a\u5730\u88ab\u7528\u4f5c\u63a7\u5236\u8840\u538b\u548c\u76f8\u5173\u5e76\u53d1\u75c7\u7684\u7efc\u5408\u7597\u6cd5\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B8\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6069\u65af\u7279\uff0c2005<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B75\" aria-expanded=\"false\" aria-haspopup=\"true\">\u738b\u7b49\u4eba\uff0c2012<\/a>\uff09\u3002\u4e00\u9879\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\u4e86\u706f\u76cf\u82b1\u6ce8\u5c04\u6db2\u5bf9\u8001\u5e74\u539f\u53d1\u6027\u9ad8\u8840\u538b\u60a3\u8005\u80be\u529f\u80fd\u7684\u5f71\u54cd\u3002\u7ed3\u679c\u8868\u660e\uff0c\u706f\u76cf\u82b1\u6ce8\u5c04\u6db2\uff08\u4e3b\u8981\u6210\u5206\u4e3a\u706f\u76cf\u82b1\u7d20\uff09\uff0840ml\uff0cqd\uff09\u5177\u6709\u4e0e\u4f9d\u90a3\u666e\u5229\uff0820mg\uff0cqd\uff09\u76f8\u4f3c\u7684\u6297\u9ad8\u8840\u538b\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u5c3fNAG\u548c\u03b2<sub>2<\/sub>\u706f\u76cf\u82b1\u7d20\u7ec4\u7684-MG\u663e\u7740\u4e0b\u964d\uff0c\u8fd9\u8868\u660e\u706f\u76cf\u82b1\u7d20\u53ef\u80fd\u6539\u5584\u8fd9\u4e9b\u60a3\u8005\u7684\u80be\u5c0f\u7ba1\u529f\u80fd\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B72\" aria-expanded=\"false\" aria-haspopup=\"true\">\u738b\uff0c2000<\/a>\uff09\u3002\u53e6\u4e00\u9879\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u65e8\u5728\u7814\u7a76\u706f\u76cf\u82b1\u7d20\u5bf9\u6025\u6027\u9ad8\u8840\u538b\u8111\u51fa\u8840\u60a3\u8005\u7684\u7597\u6548\u3002\u60a3\u8005\u5747\u91c7\u7528\u706f\u76cf\u82b1\u7d20\u52a0\u5e38\u89c4\u897f\u836f\u6cbb\u7597\uff08<em>n<\/em>\u00a0= 39\uff09\u6216\u5355\u72ec\u5e38\u89c4\u897f\u533b\uff08<em>n<\/em>\u00a0= 39) \u4e24\u5468\u3002\u706f\u76cf\u82b1\u7d20\u7ec4\u7684\u8840\u80bf\u91cf\u3001\u6c34\u80bf\u9762\u79ef\u548c\u65af\u582a\u7684\u7eb3\u7ef4\u4e9a\u5352\u4e2d\u91cf\u8868\uff08SSS\uff09\u7ed3\u679c\u5747\u660e\u663e\u4f18\u4e8e\u5bf9\u7167\u7ec4\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B63\" aria-expanded=\"false\" aria-haspopup=\"true\">\u65bd\u548c\u4e01\uff0c2009<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.e.f\" class=\"sec\">\n<h3 id=\"sec-a.l.e.ftitle\">\u5fc3\u5f8b\u5931\u5e38<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u5728\u4e34\u5e8a\u5b9e\u8df5\u4e2d\uff0c\u5927\u591a\u6570\u5fc3\u5f8b\u5931\u5e38\u7684\u6cbb\u7597\u65b9\u6cd5\u90fd\u662f\u6709\u533b\u5b66\u6307\u5f81\u7684\u3002\u7136\u800c\uff0cAF\uff0c\u4e00\u79cd\u4e25\u91cd\u7684\u5fc3\u5f8b\u5931\u5e38\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B45\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8292\u683c\u7b49\u4eba\uff0c2014<\/a>\uff09\uff0c\u4ecd\u7136\u4e0d\u5bb9\u6613\u89e3\u51b3\u3002 AF \u662f\u5fc3\u6e90\u6027\u731d\u6b7b\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u5360\u5168\u7403 CVD \u6b7b\u4ea1\u4eba\u6570\u7684\u4e00\u534a\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B42\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6885\u8d6b\u62c9\uff0c2007<\/a>\uff09\u3002\u5c3d\u7ba1\u706f\u76cf\u82b1\u7d20\u7684\u6297\u5fc3\u5f8b\u5931\u5e38\u4f5c\u7528\u5df2\u5728\u591a\u9879\u52a8\u7269\u7814\u7a76\u4e2d\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u4f46\u4e34\u5e8a\u8bd5\u9a8c\u8fd8\u5f88\u5c11\u3002\u4e00\u9879\u7531 30 \u540d\u6301\u7eed\u6027\u623f\u98a4\u8001\u5e74\u60a3\u8005\u7ec4\u6210\u7684\u75c5\u4f8b\u7cfb\u5217\uff0c\u63a5\u53d7\u706f\u76cf\u82b1\u7d20\u6ce8\u5c04\u6db2\uff0836 mg\uff0c\u9759\u8109\u6ef4\u6ce8\uff0c\u6bcf\u65e5\u4e00\u6b21\uff092 \u5468\uff0c\u62a5\u544a\u6cbb\u7597\u540e\u60a3\u8005\u5fc3\u7387\u4ece 115.4 \u00b1 8.2 \u4e0b\u964d\u81f3 83.3 \u00b1 7.6\u3002\u62a5\u544a\u7684\u4e0d\u826f\u4e8b\u4ef6\u5305\u62ec\u4e09\u4f8b\u5934\u6655\uff0c\u4f46\u5747\u81ea\u884c\u7f13\u89e3\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B19\" aria-expanded=\"false\" aria-haspopup=\"true\">\u97e9, 1999<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.e.g\" class=\"sec\">\n<h3 id=\"sec-a.l.e.gtitle\">\u9ad8\u8102\u8840\u75c7<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u9ad8\u8102\u8840\u75c7\u662f\u8840\u6db2\u4e2d\u8102\u8d28\u5f02\u5e38\u5347\u9ad8\uff0c\u901a\u5e38\u6307\u8840\u6e05\u80c6\u56fa\u9187\u548c\u7518\u6cb9\u4e09\u916f\u5347\u9ad8\u3002\u9ad8\u80c6\u56fa\u9187\u548c\u7518\u6cb9\u4e09\u916f\u4f1a\u589e\u52a0\u60a3\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u98ce\u9669\u3002\u6570\u636e\u663e\u793a\uff0c\u5982\u679c\u8840\u6e05\u80c6\u56fa\u9187\u964d\u4f4e10%\uff0c40\u5c81\u7537\u6027\u7684\u5fc3\u810f\u75c5\u60a3\u75c5\u7387\u5c06\u5728\u4e94\u5e74\u5185\u964d\u4f4e50%\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B43\" aria-expanded=\"false\" aria-haspopup=\"true\">\u95e8\u8fea\u65af\u7b49\u4eba\uff0c2011<\/a>\uff09\u3002\u56e0\u6b64\uff0c\u6709\u5fc5\u8981\u63a7\u5236\u8840\u6e05\u80c6\u56fa\u9187\u548cTGs\u7684\u6c34\u5e73\u3002\u52a8\u7269\u7814\u7a76\u53d1\u73b0\u706f\u76cf\u82b1\u7d20\u53ef\u4ee5\u5e2e\u52a9\u964d\u4f4e\u5347\u9ad8\u7684\u8840\u8102\u3002\u8fd8\u8fdb\u884c\u4e86\u4e00\u9879\u4e34\u5e8a\u7814\u7a76\uff0c\u89c2\u5bdf\u5176\u5bf9\u9ad8\u8102\u8840\u75c7\u60a3\u8005\u7684\u5f71\u54cd\u3002\u7ed3\u679c\u663e\u793a\uff0c\u6bcf\u65e5\u670d\u7528 25 \u6beb\u514b\u706f\u76cf\u82b1\u7d20\u6cbb\u7597\u4e24\u5468\u540e\uff0c\u603b\u80c6\u56fa\u9187 (TC)\u3001LDL-c \u548c TG \u6c34\u5e73\u6709\u6240\u4e0b\u964d\u3002\u76f8\u53cd\uff0cHDL-c \u6c34\u5e73\u589e\u52a0\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B91\" aria-expanded=\"false\" aria-haspopup=\"true\">\u4f59, 2011<\/a>\uff09\u3002\u53e6\u4e00\u9879\u8bd5\u9a8c\u7814\u7a76\u4e86 36 \u540d\u60a3\u6709\u9ad8\u8102\u8840\u75c7\u7684\u8001\u5e74\u60a3\u8005\uff0c\u4ed6\u4eec\u63a5\u53d7\u706f\u76cf\u82b1\u6ce8\u5c04\u6db2\uff0830 \u6beb\u514b\uff0c\u6bcf\u65e5\u4e00\u6b21\uff092 \u5468\u3002\u5f97\u5230\u4e86\u7c7b\u4f3c\u7684\u7ed3\u679c\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B82\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6587\u548c\u962e\uff0c2004<\/a>\uff09\u3002\u53e6\u4e00\u9879\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u65e8\u5728\u7814\u7a76\u706f\u76cf\u82b1\u7d20\u5bf9\u4f34\u6709\u9ad8\u8102\u8840\u75c7\u7684\u4e0d\u7a33\u5b9a\u578b\u5fc3\u7ede\u75db\u60a3\u8005\u7684\u7597\u6548\u3002\u6d4b\u8bd5\u7ec4\u548c\u5bf9\u7167\u7ec4\u5747\u672a\u63a5\u53d7\u4ed6\u6c40\u7c7b\u836f\u7269\u6cbb\u7597\u3002\u8bd5\u9a8c\u7ec4\u7684\u8840\u8102\u3001WBV\u548cPV\u7ed3\u679c\u663e\u793a\u51fa\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u7740\u5dee\u5f02\u3002\u6b64\u5916\uff0c\u6d4b\u8bd5\u7ec4\u7684\u5fc3\u7ede\u75db\u6301\u7eed\u65f6\u95f4\u4e5f\u51cf\u5c11\u4e86\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B51\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f6d\u548c\u53f6\uff0c2011<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.e.h\" class=\"sec\">\n<h3 id=\"sec-a.l.e.htitle\">\u75c5\u6bd2\u6027\u5fc3\u808c\u708e<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u75c5\u6bd2\u6027\u5fc3\u808c\u708e\u662f\u7531\u75c5\u6bd2\u611f\u67d3\u5f15\u8d77\u7684\u5fc3\u808c\u708e\u75c7\u3002\u5b83\u6709\u52a9\u4e8e\u5fc3\u529b\u8870\u7aed\u7684\u53d1\u5c55\u3002\u76ee\u524d\uff0c\u5bf9\u75c7\u6cbb\u7597\u662fVMC\u7684\u4e3b\u8981\u6cbb\u7597\u65b9\u6cd5\uff0c\u5176\u4ed6\u7597\u6cd5\uff0c\u5982\u9759\u8109\u6ce8\u5c04\u514d\u75ab\u7403\u86cb\u767d\uff08IVIG\uff09\u6216\u8349\u836f\u5c1a\u672a\u663e\u793a\u51fa\u4efb\u4f55\u57fa\u4e8e\u8bc1\u636e\u7684\u76ca\u5904\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B55\" aria-expanded=\"false\" aria-haspopup=\"true\">\u7f57\u5bbe\u900a\u7b49\u4eba\uff0c2005<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B36\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5218\u7b49\u4eba\uff0c2012<\/a>\uff09\u3002\u591a\u9879\u7814\u7a76\u5df2\u8bc1\u660e\u706f\u76cf\u82b1\u7d20\u5bf9 VMC \u7684\u5f71\u54cd\u3002\u4e00\u9879\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u65e8\u5728\u7814\u7a76\u706f\u76cf\u82b1\u7d20\u6ce8\u5c04\u6db2\u5bf9 VMC \u513f\u7ae5\u6bcf\u5929\u6ce8\u5c04 10 mg \u706f\u76cf\u82b1\u7d20\u7684\u5fc3\u7387\u51cf\u901f\u80fd\u529b\uff08DC\uff0c\u4e00\u79cd\u5b9a\u91cf\u68c0\u6d4b\u81ea\u4e3b\u795e\u7ecf\u5f20\u529b\u7684\u6280\u672f\uff09\u7684\u5f71\u54cd\u3002<em>n<\/em>\u00a0= 30) \u6216 100 U \u8f85\u9176 A (CoA) \u548c 40 mg \u4e09\u78f7\u9178\u817a\u82f7 (ATP) (<em>n<\/em>\u00a0= 30) 2 \u5468\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u706f\u76cf\u82b1\u7d20\u7ec4\u7684 DC \u663e\u7740\u5347\u9ad8\u3002\u7814\u7a76\u4eba\u5458\u8fd8\u53d1\u73b0\uff0c\u6d4b\u8bd5\u7ec4\u7684 CK-MB \u4e0b\u964d\u5e45\u5ea6\u6bd4\u5bf9\u7167\u7ec4\u66f4\u660e\u663e\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B17\" aria-expanded=\"false\" aria-haspopup=\"true\">\u987e\u7b49\uff0c2014<\/a>\uff09\u3002\u53e6\u4e00\u9879\u7814\u7a76\u62a5\u544a\u4e86\u7c7b\u4f3c\u7684\u7ed3\u679c\uff1b\u7814\u7a76\u4eba\u5458\u8bc1\u660e\u4e86TNF-\u03b1\uff0c\u4e00\u79cd\u53ef\u4ee5\u53cd\u6620\u5fc3\u808c\u708e\u75c7\u7a0b\u5ea6\u7684\u7ec6\u80de\u56e0\u5b50\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B26\" aria-expanded=\"false\" aria-haspopup=\"true\">\u4f26\u4f50\u7b49\u4eba\uff0c2001<\/a>\uff09\uff0c\u5728\u706f\u76cf\u82b1\u7d20\u7ec4\u4e2d\u660e\u663e\u4e0b\u964d\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B78\" aria-expanded=\"false\" aria-haspopup=\"true\">\u738b\u548c\u738b\uff0c2009<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.e.i\" class=\"sec\">\n<h3 id=\"sec-a.l.e.ititle\">\u6162\u6027\u5fc3\u529b\u8870\u7aed<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u6162\u6027\u5fc3\u529b\u8870\u7aed\u901a\u5e38\u53d1\u751f\u5728\u5927\u591a\u6570\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u672b\u671f\u3002\u6d41\u884c\u75c5\u5b66\u8c03\u67e5\u663e\u793a\uff0c\u53d1\u8fbe\u56fd\u5bb6\u6210\u4ebaCHF\u60a3\u75c5\u7387\u7ea6\u4e3a2%\uff0c\u6211\u56fd\u4e3a0.9%\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B16\" aria-expanded=\"false\" aria-haspopup=\"true\">\u987e\u7b49\u4eba\uff0c2002<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B41\" aria-expanded=\"false\" aria-haspopup=\"true\">\u9ea6\u514b\u9ed8\u91cc\u548c\u666e\u8d39\u5f17\uff0c2005<\/a>\uff09\u3002\u5c3d\u7ba1\u670930-40%\u7684\u60a3\u8005\u5728CVD\u8bca\u65ad\u540e\u4e00\u5e74\u5185\u6b7b\u4ea1\uff0c\u4f46\u6bcf\u5e74\u7684\u6b7b\u4ea1\u7387\u4f4e\u4e8e10%\u3002\u9700\u8981\u89e3\u51b3\u7684\u5173\u952e\u95ee\u9898\u662f\u5bf9QOL\u7684\u5f71\u54cd\uff0c\u6bd4\u5982\u60c5\u7eea\u969c\u788d\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B46\" aria-expanded=\"false\" aria-haspopup=\"true\">\u56fd\u5bb6\u4e34\u5e8a\u6307\u5bfc\u4e2d\u5fc3\uff0c2010<\/a>\uff09\u3002\u5728\u4e00\u9879\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u4e2d\uff0c100 \u540d NYHA III\u223cIV \u671f\u5c04\u8840\u5206\u6570\u6b63\u5e38\u7684\u5fc3\u529b\u8870\u7aed (HF-NEF) \u60a3\u8005\u88ab\u6307\u5bfc\u670d\u7528 40 mg\/d \u706f\u76cf\u82b1\u7d20\u52a0\u5e38\u89c4\u836f\u7269\u6216\u5355\u72ec\u5e38\u89c4\u836f\u7269\u6cbb\u7597 10 \u5929\u3002\u7ed3\u679c\u53c2\u6570\u8868\u660e\uff0c\u6d4b\u8bd5\u7ec4\u7684 B \u578b\u5229\u5c3f\u94a0\u80bd (BNP) \u4e0b\u964d\u66f4\u591a\u3002\u7136\u800c\uff0c\u6d4b\u8bd5\u7ec4\u548c\u5bf9\u7167\u7ec4\u4e4b\u95f4\u7684 LVEF \u548c\u5de6\u5fc3\u5ba4\u8212\u5f20\u672b\u671f\u5bb9\u79ef (LVEDV) \u6ca1\u6709\u5dee\u5f02\u3002\u6b64\u5916\uff0c\u8bd5\u9a8c\u7ec4\u7684\u6c14\u77ed\u3001\u80f8\u95f7\u3001\u4e4f\u529b\u3001\u65e0\u529b\u7b49\u5178\u578b\u75c7\u72b6\u6bd4\u5bf9\u7167\u7ec4\u6709\u5f88\u5927\u6539\u5584\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B93\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f20\u82b3, 2014<\/a>\uff09\u3002\u4e00\u9879\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u5728 126 \u540d NYHA II\u223cIII \u671f\u60a3\u8005\u4e2d\u8fdb\u884c\uff0c\u8fd9\u4e9b\u60a3\u8005\u88ab\u968f\u673a\u7ed9\u4e88\u706f\u76cf\u82b1\u7d20\uff0850 mg\uff0cqd\uff09\u4e0e\u5e38\u89c4\u836f\u7269\u6216\u5355\u72ec\u5e38\u89c4\u836f\u7269\u6cbb\u7597 2 \u5468\u3002\u7ed3\u679c\u663e\u793a\uff0c\u8054\u5408\u7ec4\u7684 LVEF \u548c 6 \u5206\u949f\u6b65\u884c\u6d4b\u8bd5\uff086 MWT\uff09\u660e\u663e\u4f18\u4e8e\u5bf9\u7167\u7ec4\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B68\" aria-expanded=\"false\" aria-haspopup=\"true\">\u7530, 2010<\/a>\uff09\u3002\u53e6\u4e00\u9879\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\u4e86 46 \u540d NYHA III\u223cIV \u671f\u4e25\u91cd\u5fc3\u529b\u8870\u7aed\u60a3\u8005\uff0c\u5f97\u5230\u4e86\u7c7b\u4f3c\u7684\u7ed3\u679c\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B27\" aria-expanded=\"false\" aria-haspopup=\"true\">\u674e\uff0c2007<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.e.j\" class=\"sec sec-last\">\n<h3 id=\"sec-a.l.e.jtitle\">\u80ba\u5fc3\u75c5<\/h3>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u80ba\u5fc3\u75c5\u5bfc\u81f4\u5fc3\u529b\u8870\u7aed\u548c\/\u6216\u547c\u5438\u8870\u7aed\u3002\u538b\u529b\u540e\u8d1f\u8377\u662f\u8be5\u75be\u75c5\u7684\u7b2c\u4e00\u6b65\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B69\" aria-expanded=\"false\" aria-haspopup=\"true\">Voelkel \u7b49\u4eba\uff0c2013<\/a>\uff09\u3002\u76ee\u524d\uff0c\u6297\u751f\u7d20\u3001\u6c27\u7597\u3001\u6297\u51dd\u5242\u548c\u8840\u7ba1\u6269\u5f20\u5242\u662fPHD\u7684\u4e3b\u8981\u6cbb\u7597\u65b9\u6cd5\u3002\u591a\u9879\u7814\u7a76\u8868\u660e\u4e2d\u836f\uff08\u53c2\u9ea6\u6ce8\u5c04\u6db2\uff09\u8054\u5408\u5e38\u89c4\u6cbb\u7597\u5bf9\u8be5\u75c5\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B62\" aria-expanded=\"false\" aria-haspopup=\"true\">\u65bd\u7b49\u4eba\uff0c2015<\/a>\uff09\u3002\u4e5f\u6709\u4e00\u4e9b\u7814\u7a76\u62a5\u544a\u4e86\u706f\u76cf\u82b1\u7d20\u5bf9 PHD \u7684\u5f71\u54cd\u3002\u4e00\u9879\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u8c03\u67e5\u4e86\u706f\u76cf\u82b1\u7d20\u5bf9 83 \u540d PHD \u60a3\u8005\u7684\u5f71\u54cd\uff0c\u8fd9\u4e9b\u60a3\u8005\u63a5\u53d7\u5e38\u89c4\u836f\u7269\u52a0 40 mg\/d \u706f\u76cf\u82b1\u7d20\u6216\u5355\u72ec\u5e38\u89c4\u836f\u7269\u6cbb\u7597 28 \u5929\u3002\u7ed3\u679c\u8868\u660e\uff0c\u78b1\u6027\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff08bFGF\uff0c\u4e00\u79cd\u80fd\u8bf1\u5bfc\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u7684\u591a\u80bd\uff09\u3001\u6c27\u5206\u538b\uff08PaO<sub>2<\/sub>\uff09\u548c\u706f\u76cf\u82b1\u7d20\u7ec4\u7684\u5e73\u5747\u80ba\u52a8\u8109\u538b\uff08mPAP\uff09\u663e\u7740\u6539\u5584\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B13\" aria-expanded=\"false\" aria-haspopup=\"true\">\u9ad8\u548c\u6881\uff0c2009<\/a>\uff09\u3002\u53e6\u4e00\u9879\u8bd5\u9a8c\u4e5f\u89c2\u5bdf\u4e86\u706f\u76cf\u82b1\u7d20\u5bf9 PHD \u60a3\u8005\u7684\u5f71\u54cd\uff1b\u706f\u76cf\u82b1\u7d20\u7ec4\u4e0e\u5bf9\u7167\u7ec4\u7684\u7ea2\u7ec6\u80de\u53d8\u5f62\u80fd\u529b\u548c\u767d\u7ec6\u80de\u6d3b\u5316\u7ed3\u679c\u663e\u793a\u51fa\u663e\u7740\u5dee\u5f02\u3002\u6709\u4eba\u63d0\u51fa\uff0c\u706f\u76cf\u82b1\u7d20\u53ef\u80fd\u901a\u8fc7\u6539\u5584\u7ea2\u7ec6\u80de\u53d8\u5f62\u6027\u548c\u767d\u7ec6\u80de\u6d3b\u5316\u6765\u963b\u6b62PHD\u7684\u8fdb\u5c55\uff0c\u4ece\u800c\u5f71\u54cd\u5931\u4ee3\u507f\u6027\u6162\u6027PHD\u60a3\u8005\u7684\u8840\u6e05\u9ad8\u51dd\u72b6\u6001\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B25\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5b54\u7b49\u4eba\uff0c2006<\/a>\uff09\u3002\u4e00\u9879\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\u4e86\u706f\u76cf\u82b1\u7d20\u5bf9 PHD \u6025\u6027\u52a0\u91cd\u60a3\u8005\u7684\u5f71\u54cd\u3002\u7ed3\u679c\u663e\u793a\uff0c\u8bd5\u9a8c\u7ec4\u7684\u547c\u5438\u56f0\u96be\u3001\u54b3\u55fd\u3001\u6c34\u80bf\u3001\u53d1\u7ec0\u7b49\u75c7\u72b6\u6bd4\u5bf9\u7167\u7ec4\u6709\u66f4\u591a\u6539\u5584\u3002\u6b64\u5916\uff0c\u6d4b\u8bd5\u7ec4\u7684WBV\u3001FIB\u7b49\u4e00\u4e9b\u6307\u6807\u4e5f\u6709\u660e\u663e\u4e0b\u964d\uff0c\u8bf4\u660e\u8840\u6db2\u7c98\u5ea6\u6709\u6240\u6539\u5584\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B3\" aria-expanded=\"false\" aria-haspopup=\"true\">\u66f9\u7b49\u4eba\uff0c2006<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<div id=\"sec-a.l.f\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"sec-a.l.ftitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u5242\u91cf\u548c\u526f\u4f5c\u7528<\/h2>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u706f\u76cf\u82b1\u7d20\u4ee5\u6ce8\u5c04\u5242\u548c\u53e3\u670d\u5242\u7684\u5f62\u5f0f\u5e7f\u6cdb\u5e94\u7528\u4e8e\u4e34\u5e8a\u3002\u6ce8\u5c04\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u65e55\uff5e20mg\uff0c\u4e00\u6b21\uff1b\u53e3\u670d\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u65e5120\uff5e240mg\uff0c\u52063\u6b21\u670d\u7528\u3002\u7531\u4e8e\u5176\u6c34\u6eb6\u6027\u5dee\u3001\u751f\u7269\u5229\u7528\u5ea6\u4f4e\u00a0<em>\u4f53\u5185<\/em>\uff0c\u8bb8\u591a\u65b0\u7684\u9012\u9001\u65b9\u6cd5\u88ab\u8bbe\u8ba1\u548c\u5f00\u53d1\uff0c\u5305\u62ec\u5206\u6563\u7247\u3001\u6ef4\u4e38\u3001\u8102\u8d28\u4f53\u3001\u7eb3\u7c73\u9897\u7c92\u3001\u7eb3\u7c73\u4e73\u5242\u548c\u8102\u80aa\u4e73\u5242\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B103\" aria-expanded=\"false\" aria-haspopup=\"true\">\u949f\u7b49\uff0c2005<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B50\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5e15\u7279\u5c14\u7b49\u4eba\uff0c2012<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B39\" aria-expanded=\"false\" aria-haspopup=\"true\">\u9a6c\u7b49\u4eba\uff0c2015<\/a>\uff09\u3002\u706f\u76cf\u82b1\u7d20\u7684\u4e0d\u826f\u53cd\u5e94\u5927\u591a\u53d1\u751f\u5728\u6ce8\u5c04\u8fc7\u7a0b\u4e2d\u3002\u4e00\u9879\u5bf9\u706f\u76cf\u82b1\u7d20\u4e0d\u826f\u53cd\u5e94\u7684\u835f\u8403\u5206\u6790\u5305\u62ec 1761 \u540d\u60a3\u8005\u7684 33 \u9879\u4e34\u5e8a\u7814\u7a76\u3002\u603b\u4f53\u62a5\u544a\u4e0d\u826f\u53cd\u5e9472\u4f8b\uff0c\u53d1\u751f\u7387\u4e3a4.09%\u3002\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u8fc7\u654f\u3001\u76ae\u80a4\u7619\u75d2\u3001\u76ae\u75b9\u3001\u9762\u90e8\u6f6e\u7ea2\u3001\u80f8\u95f7\u3001\u5fc3\u60b8\u3001\u5934\u6655\/\u7729\u6655\u3001\u5934\u75db\u548c\u80c3\u80a0\u9053\u4e0d\u9002\u3002\u7136\u800c\uff0c\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u8005\u8fd8\u53d1\u73b0\uff0c\u706f\u76cf\u82b1\u7d20\u6ce8\u5c04\u6db2\u4e0e\u5bf9\u5e94\u836f\u7269\u76f8\u6bd4\uff0c\u4e0d\u826f\u53cd\u5e94\u6ca1\u6709\u663e\u7740\u5dee\u5f02\uff0c\u5c24\u5176\u662f\u572815\u5929\u5185\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B10\" aria-expanded=\"false\" aria-haspopup=\"true\">\u51af\u7b49\uff0c2016<\/a>\uff09\u3002\u5173\u4e8e\u836f\u7269\u76f8\u4e92\u4f5c\u7528\uff0c\u706f\u76cf\u82b1\u7d20\u53ef\u4ee5\u5728\u77ed\u671f\u5185\u6291\u5236 CYP1A2 \u4ecb\u5bfc\u7684\u975e\u90a3\u897f\u4e01\u4ee3\u8c22\u3002\u00a0<em>\u4f53\u5916<\/em>\u00a0\u5b9e\u9a8c\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B53\" aria-expanded=\"false\" aria-haspopup=\"true\">\u79e6\u7b49\uff0c2012<\/a>) \u5e76\u6291\u5236 CYP3A4 \u7684\u6d3b\u6027\u00a0<em>\u4f53\u5185<\/em>\u3002\u706f\u76cf\u82b1\u7d20\u8fd8\u663e\u7740\u589e\u52a0\u5927\u9f20\u4f53\u5185\u6c28\u82ef\u781c\u7684\u8840\u6d46\u6d53\u5ea6\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B34\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5218\u7b49\u4eba\uff0c2013<\/a>\uff09\u3002\u706f\u76cf\u82b1\u6ce8\u5c04\u6db2\u7684\u4e34\u5e8a\u5b89\u5168\u6027\u548c\u5408\u7406\u5e94\u7528\u660e\u786e\u6307\u51fa\u706f\u76cf\u82b1\u7d20\u4e0e\u4e0b\u5217\u836f\u7269\u4e0d\u76f8\u914d\u4f0d\uff1a\u6c28\u82c4\u897f\u6797\u94a0\u3001\u786b\u9178\u5e86\u5927\u9709\u7d20\u3001\u6c2f\u9709\u7d20\u3001\u4e73\u9178\u73af\u4e19\u6c99\u661f\u3001\u786b\u9178\u9541\u3001\u76d0\u9178\u666e\u9c81\u5361\u56e0\u3001\u5934\u5b62\u62c9\u5b9a\u3001\u4f4e\u5206\u5b50\u53f3\u65cb\u7cd6\u9150\u3001\u901f\u5c3f\u3001\u918b\u9178\u6c22\u5316\u6cfc\u5c3c\u677e\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B100\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8d75\u7b49\u4eba\uff0c2008<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.g\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"sec-a.l.gtitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u7ed3\u8bba\u4e0e\u5c55\u671b<\/h2>\n<p>&nbsp;<\/p>\n<p class=\"p p-first\">\u4e2d\u836f\u5728\u6211\u56fd\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u9632\u6cbb\u4e2d\u7ee7\u7eed\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002\u4e0e\u897f\u836f\u4e0d\u540c\uff0c\u4e2d\u836f\u7684\u6574\u4f53\u6027\u548c\u534f\u540c\u6027\u6e90\u4e8e\u5176\u8349\u836f\u6210\u5206\uff0c\u5176\u4e2d\u5305\u542b\u6570\u767e\u79cd\u5316\u5408\u7269\uff0c\u901a\u8fc7\u591a\u79cd\u5316\u5408\u7269\u4e0e\u591a\u4e2a\u4e0d\u540c\u9776\u70b9\u7684\u7ed3\u5408\u6765\u53d1\u6325\u4f5c\u7528\uff0c\u4ece\u800c\u63d0\u9ad8\u5176\u5bf9\u590d\u6742\u75be\u75c5\u7684\u7cfb\u7edf\u5e72\u9884\u6548\u679c\u3002\u7136\u800c\uff0c\u4e2d\u836f\u7684\u4f5c\u7528\u673a\u5236\u5c1a\u4e0d\u6e05\u695a\uff0c\u8fd9\u4f7f\u5f97\u4e16\u754c\u5176\u4ed6\u56fd\u5bb6\u5f88\u96be\u4e86\u89e3\u5176\u4f5c\u7528\u539f\u7406\u5e76\u963b\u788d\u5176\u5168\u7403\u5e94\u7528\u3002\u56e0\u6b64\uff0c\u8349\u836f\u5c42\u9762\u7684\u7814\u7a76\u53ef\u80fd\u662f\u5168\u9762\u4e86\u89e3\u4e2d\u836f\u7684\u597d\u65b9\u6cd5\u3002\u4ee5\u5f80\u4e2d\u836f\u590d\u65b9\u7814\u7a76\u7684\u4e3b\u8981\u7b56\u7565\u4e4b\u4e00\u5c31\u662f\u7814\u7a76\u5176\u4f5c\u7528\u673a\u5236\u3002\u7531\u4e8e\u5b58\u5728\u591a\u79cd\u5316\u5408\u7269\uff0c\u59cb\u7ec8\u4e0d\u6e05\u695a\u54ea\u4e9b\u6210\u5206\u4ea7\u751f\u771f\u6b63\u7684\u6548\u679c\u3002\u4e2d\u8349\u836f\uff08CHM\uff09\u7684\u5355\u4f53\u6210\u5206\uff0c\u53c8\u79f0\u5929\u7136\u7eaf\u590d\u65b9\u836f\u7269\uff0c\u8fd1\u5e74\u6765\u5907\u53d7\u5173\u6ce8\u3002\u5929\u7136\u63d0\u53d6\u7269\u9752\u84bf\u7d20\u53ca\u5176\u884d\u751f\u7269\u662f\u4e2d\u836f\u5355\u4f53\u6210\u5206\u7684\u826f\u597d\u4f8b\u5b50\uff0c\u53ef\u4ee5\u901a\u8fc7\u591a\u79cd\u6d3b\u6027\u6cbb\u7597\u75be\u75c5\uff0c\u5e76\u4e14\u53ef\u4ee5\u6210\u4e3a\u63ed\u793a\u4e2d\u836f\u673a\u5236\u7684\u826f\u597d\u8d77\u70b9\u3002<\/p>\n<p>\u540c\u6837\uff0c\u5728\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u91cc\uff0c\u4eba\u4eec\u5bf9\u5927\u91cf\u5177\u6709\u5fc3\u8840\u7ba1\u4f5c\u7528\u7684\u4e2d\u836f\u5355\u4f53\u6210\u5206\u8fdb\u884c\u4e86\u7814\u7a76\u3002\u4f8b\u5982\uff0c\u5df2\u7ecf\u5bf9\u4e39\u915a\u9178 B \u8fdb\u884c\u4e86\u591a\u9879\u7cfb\u7edf\u8bc4\u4ef7\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B74\" aria-expanded=\"false\" aria-haspopup=\"true\">\u738b\u6770\u7b49\uff0c2013<\/a>)\u3001\u56db\u7532\u57fa\u5421\u55ea (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B44\" aria-expanded=\"false\" aria-haspopup=\"true\">\u660e\u7b49\u4eba\uff0c2016<\/a>),\u00a0<em>\u4e09\u4e03<\/em>\u00a0\u7682\u7519\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#B89\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6768\u7b49\u4eba\uff0c2014<\/a>\u5176\u4e2d\uff0c\u706f\u76cf\u82b1\u7d20\u7684\u4e3b\u8981\u6210\u5206\u706f\u76cf\u4e59\u7d20\u662f\u4e2d\u836f\u5355\u4f53\u6210\u5206\u7684\u4e00\u79cd\uff0c\u706f\u76cf\u82b1\u7d20\u5177\u6709\u663e\u7740\u7684\u8840\u7ba1\u8212\u5f20\u4f5c\u7528\uff08\u6539\u5584\u52c3\u8d77\u529f\u80fd\uff09\uff1b\u9632\u6b62 I\/R\uff1b\u6297\u51dd\u548c\u6297\u8840\u6813\u5f62\u6210\uff1b\u51cf\u5c11\u5e73\u6ed1\u808c\u7ec6\u80de\u8fc1\u79fb\u548c\u589e\u6b96\uff1b\u6297\u5fc3\u810f\u91cd\u6784\uff1b\u6297\u5fc3\u5f8b\u5931\u5e38\u3001\u964d\u4f4e\u8840\u8102\u3002\u7531\u4e8e\u5176\u6297\u708e\u4f5c\u7528\uff0c\u706f\u76cf\u82b1\u7d20\u8fd8\u5bf9\u5fc3\u808c\u548c\u5185\u76ae\u7ed3\u6784\u5177\u6709\u4fdd\u62a4\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u56de\u987e\u4e34\u5e8a\u7814\u7a76\uff0c\u6211\u4eec\u8ba4\u4e3a\u706f\u76cf\u82b1\u7d20\u6700\u663e\u7740\u7684\u7279\u70b9\u662f\u5b83\u5177\u6709\u8c03\u8282\u8840\u7ba1\u7684\u591a\u79cd\u529f\u80fd\uff0c\u8fd9\u4e9b\u529f\u80fd\u4e0e\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u4e2d\u98ce\u548c\u7cd6\u5c3f\u75c5\u6709\u5173\u3002<\/p>\n<p class=\"p p-last\">\u5c3d\u7ba1\u706f\u76cf\u82b1\u7d20\u5728\u9884\u9632\u548c\u6cbb\u7597\u5fc3\u8840\u7ba1\u75be\u75c5\u65b9\u9762\u5177\u6709\u5e7f\u6cdb\u7684\u5fc3\u8840\u7ba1\u4f5c\u7528\uff0c\u4f46\u4e5f\u6709\u4e00\u4e9b\u95ee\u9898\u9700\u8981\u6211\u4eec\u8003\u8651\u3002\u9996\u5148\uff0c\u6211\u4eec\u56de\u987e\u7684\u4e0a\u8ff0\u5b9e\u9a8c\u7814\u7a76\u96c6\u4e2d\u5728\u706f\u76cf\u82b1\u7d20\u4f5c\u7528\u673a\u5236\u7684\u4e00\u4e2a\u65b9\u9762\uff0c\u7531\u4e8e\u65b9\u6cd5\u5b66\u8d28\u91cf\u8f83\u4f4e\uff0c\u5f88\u5c11\u6709\u7814\u7a76\u80fd\u591f\u5f97\u51fa\u660e\u786e\u7684\u7ed3\u8bba\uff0c\u5e76\u4e14\u6ca1\u6709\u4e00\u9879\u7814\u7a76\u9a8c\u8bc1\u4e86\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u00a0<em>\u4f53\u5916<\/em>\u00a0\u548c\u00a0<em>\u4f53\u5185<\/em>\u3002\u4e0e\u5176\u4ed6\u673a\u5236\u76f8\u6bd4\uff0c\u7814\u7a76\u5176\u8840\u7ba1\u8212\u5f20\u3001I\/R\u3001\u6297\u51dd\u548c\u6297\u8840\u6813\u4f5c\u7528\u7279\u6027\u7684\u7814\u7a76\u8f83\u591a\u3002\u4f46\u4e24\u9879\u7814\u7a76\u5176\u52a8\u7269\u5b9e\u9a8c\u7684\u964d\u8102\u4f5c\u7528\u7ed3\u679c\u5374\u4e0d\u540c\u3002\u6b64\u5916\uff0c\u5c1a\u65e0\u7814\u7a76\u63a2\u8ba8\u5176\u76f8\u5173\u673a\u5236\u3002\u5176\u6b21\uff0c\u7531\u4e8e\u8fd9\u4e9b\u7814\u7a76\u4e3b\u8981\u5728\u4e2d\u56fd\u53d1\u8868\uff0c\u8bc1\u636e\u7684\u5f3a\u5ea6\u53d7\u5230\u7f3a\u4e4f\u5bf9\u7167\u6216\u5b89\u6170\u5242\u3001\u975e\u968f\u673a\u3001\u975e\u76f2\u8bbe\u8ba1\u548c\/\u6216\u5c0f\u6837\u672c\u60a3\u8005\u7684\u9650\u5236\u3002\u56e0\u6b64\uff0c\u9700\u8981\u5f00\u5c55\u591a\u4e2d\u5fc3\u3001\u5927\u6837\u672c\u3001\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u6765\u8bc4\u4ef7\u706f\u76cf\u82b1\u7d20\u6cbb\u7597CVD\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u7b2c\u4e09\uff0c\u706f\u76cf\u82b1\u7d20\u7684\u526f\u4f5c\u7528\u4e3b\u8981\u53d1\u751f\u5728\u6ce8\u5c04\u65f6\uff0c\u8fd9\u8868\u660e\u5e94\u8003\u8651\u5408\u9002\u7684\u7ed9\u836f\u65b9\u5f0f\u3002\u6b64\u5916\uff0c\u6392\u9664\u6025\u6027\u8111\u51fa\u8840\u6216\u6709\u51fa\u8840\u503e\u5411\u7684\u60a3\u8005\u3002\u603b\u7684\u6765\u8bf4\uff0c\u7814\u7a76\u706f\u76cf\u82b1\u7d20\u6cbb\u7597 CVD \u7684\u7528\u9014\u975e\u5e38\u91cd\u8981\u3002\u7136\u800c\uff0c\u6240\u6709\u8fd9\u4e9b\u7d27\u8feb\u7684\u95ee\u9898\u90fd\u5e94\u8be5\u5728\u672a\u6765\u7684\u7814\u7a76\u4e2d\u5f97\u5230\u89e3\u51b3\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.h\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"sec-a.l.htitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u4f5c\u8005\u8d21\u732e<\/h2>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">JG\u548cGC\u8bbe\u8ba1\u4e86\u8bc4\u5ba1\u5de5\u4f5c\uff1b JG\u3001GC\u3001HH \u548c CL \u56de\u987e\u4e86\u6709\u5173\u8be5\u4e3b\u9898\u7684\u73b0\u6709\u6587\u732e\u5e76\u64b0\u5199\u4e86\u8bba\u6587\uff1b XX\u548cJL\u5bf9\u7a3f\u4ef6\u7684\u79d1\u5b66\u5199\u4f5c\u505a\u51fa\u4e86\u8d21\u732e\uff1b JG\u3001GC \u548c JW \u4fee\u6539\u4e86\u624b\u7a3f\u3002\u6240\u6709\u4f5c\u8005\u5747\u6279\u51c6\u8be5\u8bba\u6587\u53d1\u8868\u3002 JG\u3001GC\u3001HH \u548c CL \u5bf9\u8fd9\u9879\u5de5\u4f5c\u505a\u51fa\u4e86\u540c\u7b49\u8d21\u732e\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"sec-a.l.i\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"sec-a.l.ititle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u5229\u76ca\u51b2\u7a81\u58f0\u660e<\/h2>\n<p>&nbsp;<\/p>\n<p class=\"p p-first-last\">\u4f5c\u8005\u58f0\u660e\uff0c\u8be5\u7814\u7a76\u662f\u5728\u4e0d\u5b58\u5728\u4efb\u4f55\u53ef\u80fd\u88ab\u89c6\u4e3a\u6f5c\u5728\u5229\u76ca\u51b2\u7a81\u7684\u5546\u4e1a\u6216\u8d22\u52a1\u5173\u7cfb\u7684\u60c5\u51b5\u4e0b\u8fdb\u884c\u7684\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"fn-group-a.m.a\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"fn-group-a.m.atitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u811a\u6ce8<\/h2>\n<div class=\"fm-sec half_rhythm small\">\n<p class=\"p p-first-last\"><strong>\u8d44\u91d1\u3002<\/strong>\u00a0\u672c\u6587\u5f97\u5230\u4e86\u535a\u58eb\u521b\u65b0\u8d44\u52a9\u7684\u652f\u6301\u3002\u4e2d\u56fd\u4e2d\u533b\u79d1\u5b66\u9662\u5b66\u751f\uff0c2016CX003\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<div id=\"ref-list-a.m.b\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"ref-list-a.m.btitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u53c2\u8003<\/h2>\n<p>&nbsp;<\/p>\n<div id=\"reference-list\" class=\"ref-list-sec sec\">\n<ol class=\"back-ref-list\">\n<li id=\"B1\"><span class=\"mixed-citation\">\u674e\u6ce2\uff0c\u8d75\u560e\uff0c\u6bb7\u56fd\u901a\uff0c\u5b59\u6d77\u6d69\uff0c\u987e\u9ad8\u5cad\uff0c\u6768\u96ea\u83b2\uff082011\uff09\u3002\u00a0<span class=\"ref-title\">\u706f\u76cf\u82b1\u7d20\u7247\u5bf9\u5154\u80a5\u539a\u5fc3\u808c\u5ba4\u6027\u5fc3\u5f8b\u5931\u5e38\u7684\u5f71\u54cd<\/span>\u00a0<span class=\"ref-journal\"><em>J.\u65b0\u4e61\u533b\u5b66\u535a\u58eb\u3002\u79d1\u5c14\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">2<\/span>\u00a0154\u2013156\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.+Xinxiang+Med.+Coll.&amp;title=Effect+of+breviscapine+tablets+on+ventricular+arrhythmias+in+hypertrophic+myocardium+of+rabbit+heart.&amp;author=L.+I.+Bo&amp;author=G.+A.+Zhao&amp;author=G.+T.+Yin&amp;author=H.+Y.+Sun&amp;author=G.+U.+Gao-Ling&amp;volume=2&amp;publication_year=2011&amp;pages=154-156&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" 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aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B21\"><span class=\"mixed-citation\">\u4f55\u660e\uff0c\u859b\u6b63\uff0c\u674e\u9759\uff0c\u5468\u6ce2\uff082012\uff09\u3002\u00a0<span class=\"ref-title\">Breviscapine \u901a\u8fc7\u6291\u5236 erk1\/2 mapk \u4fe1\u53f7\u901a\u8def\u6765\u6291\u5236\u9ad8\u7cd6\u8bf1\u5bfc\u7684\u5927\u9f20\u57f9\u517b\u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de\u7684\u589e\u6b96\u548c\u8fc1\u79fb\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u836f\u7406\u5b66\u5b66\u62a5\u3002\u7f6a\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">33<\/span>\u00a0606\u2013614\u3002 10.1038\/aps.2012.6\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4010347\/\">PMC \u514d\u8d39\u6587\u7ae0<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22465949\">\u8003\u7814<\/a>] [<a href=\"https:\/\/doi.org\/10.1038%2Faps.2012.6\" target=\"_blank\" rel=\"noopener noreferrer\">\u4ea4\u53c9\u5f15\u7528<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Acta+Pharmacol.+Sin.&amp;title=Breviscapine+inhibits+high+glucose-induced+proliferation+and+migration+of+cultured+vascular+smooth+muscle+cells+of+rats+via+suppressing+the+erk1\/2+mapk+signaling+pathway.&amp;author=M.+He&amp;author=Z.+Xue&amp;author=J.+Li&amp;author=B.+Zhou&amp;volume=33&amp;publication_year=2012&amp;pages=606-614&amp;pmid=22465949&amp;doi=10.1038\/aps.2012.6&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B22\"><span class=\"mixed-citation\">\u4faf\u4e66\u751f\uff0c\u5f20\u5e86\u534e\uff0c\u5f20\u6c38\u5e86\uff082009\uff09\u3002\u00a0<span 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class=\"mixed-citation\">\u8d3eJH\uff0c\u9648KP\uff0c\u9648SX\uff0c\u5218KZ\uff0c\u8303TL\uff0c\u9648YC\uff082008\uff09\u3002\u00a0<span class=\"ref-title\">\u706f\u76cf\u82b1\u7d20\u662f\u4e00\u79cd\u4e2d\u836f\uff0c\u53ef\u51cf\u8f7b\u7cd6\u5c3f\u75c5\u5927\u9f20\u5fc3\u808c\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u5fc3\u810f\u5b66\u62a5\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">63<\/span>\u00a0757\u2013762\u3002 10.2143\/AC.63.6.2033394 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19157172\">\u8003\u7814<\/a>] [<a href=\"https:\/\/doi.org\/10.2143%2FAC.63.6.2033394\" target=\"_blank\" rel=\"noopener noreferrer\">\u4ea4\u53c9\u5f15\u7528<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Acta+Cardiol.&amp;title=Breviscapine,+a+traditional+Chinese+medicine,+alleviates+myocardial+ischaemia+reperfusion+injury+in+diabetic+rats.&amp;author=J.+H.+Jia&amp;author=K.+P.+Chen&amp;author=S.+X.+Chen&amp;author=K.+Z.+Liu&amp;author=T.+L.+Fan&amp;volume=63&amp;publication_year=2008&amp;pages=757-762&amp;pmid=19157172&amp;doi=10.2143\/AC.63.6.2033394&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B24\"><span class=\"mixed-citation\">\u5b54Q.\uff0c\u6234L.\uff0c\u738bY.\uff0c\u5f20X.\uff0c\u674eC.\uff0c\u6c5fS.\uff0c\u7b49\u3002 \uff082016\uff09\u3002\u00a0<span class=\"ref-title\">Hspa12b \u901a\u8fc7\u4ee5 pi3k\/akt\/mtor \u4f9d\u8d56\u6027\u673a\u5236\u7ef4\u6301\u5185\u76ae\u5b8c\u6574\u6027\u6765\u51cf\u8f7b\u6025\u6027\u5fc3\u808c\u7f3a\u8840\/\u518d\u704c\u6ce8\u635f\u4f24\u3002<\/span>\u00a0<span 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class=\"ref-journal\"><em>\u8fc7\u671f\u3002\u745f\u5c14\u3002\u533b\u5b66\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">12<\/span>\u00a01383\u20131397\u3002 10.3892\/etm.2016.3483\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4998064\/\">PMC \u514d\u8d39\u6587\u7ae0<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27588060\">\u8003\u7814<\/a>] [<a href=\"https:\/\/doi.org\/10.3892%2Fetm.2016.3483\" target=\"_blank\" rel=\"noopener noreferrer\">\u4ea4\u53c9\u5f15\u7528<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" 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\uff082012\uff09\u3002\u00a0<span class=\"ref-title\">\u4e2d\u6210\u836f\u516d\u5473\u5730\u9ec4\u4e38\u8054\u5408\u964d\u538b\u836f\u6cbb\u7597\u539f\u53d1\u6027\u9ad8\u8840\u538b\u7684\u4e2d\u897f\u533b\u7ed3\u5408\u65b0\u7597\u6cd5\uff1a\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u7684\u7cfb\u7edf\u8bc4\u4ef7<\/span>\u00a0<span class=\"ref-journal\"><em>\u7535\u5b50CAM<\/em><\/span>\u00a0<span class=\"ref-vol\">2012<\/span>:<span class=\"ref-iss\">714805<\/span>\u00a010.1155\/2012\/714805\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3520441\/\">PMC \u514d\u8d39\u6587\u7ae0<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23258998\">\u8003\u7814<\/a>] [<a href=\"https:\/\/doi.org\/10.1155%2F2012%2F714805\" target=\"_blank\" rel=\"noopener noreferrer\">\u4ea4\u53c9\u5f15\u7528<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" 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id=\"B80\"><span class=\"mixed-citation\">\u738bY.\uff0c\u6768X.\uff0c\u5218H.\uff0c\u5510X.(2003)\u3002\u00a0<span class=\"ref-title\">\u5f71\u54cd\u7814\u7a76\u00a0<em>\u706f\u76cf\u82b1<\/em>\u00a0\u63d0\u53d6\u7269\u7684\u6297\u51dd\u4f5c\u7528\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>J\u00b7\u94a6.\u533b\u5b66\u3002\u9a6c\u7279\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">26<\/span>\u00a0656\u2013658\u3002 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14692325\">\u8003\u7814<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.+Chin.+Med.+Mater.&amp;title=Study+on+effects+of+Erigeron+breviscapus+extract+on+anticoagulation.&amp;author=Y.+Wang&amp;author=X.+Yang&amp;author=H.+Liu&amp;author=X.+Tang&amp;volume=26&amp;publication_year=2003&amp;pages=656-658&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B81\"><span class=\"mixed-citation\">\u9b4f\u592a\u5e73\uff0c\u674e\u9759\uff0c\u77f3\u6b63\uff0c\u738b\u6c38\u519b\uff082010\uff09\u3002\u00a0<span class=\"ref-title\">\u706f\u76cf\u7ec6\u8f9b\u6ce8\u5c04\u6db2\u5bf9\u5bb6\u5154\u52a8\u8109\u7ca5\u6837\u786c\u5316\u8fdb\u5c55\u7684\u6291\u5236\u4f5c\u7528\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u674e\u65f6\u73cd\u533b\u5b66.\u9a6c\u7279\u3002\u533b\u5b66\u3002\u8d44\u6e90\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">21<\/span>\u00a0750\u2013751\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Lishizhen+Med.+Mater.+Med.+Res.&amp;title=Inhibitory+effect+of+Erigeron+injection+on+the+progression+of+atherosclerosis+in+rabbits.&amp;author=J.+P.+Wei&amp;author=J.+Li&amp;author=Z.+Shi&amp;author=Y.+J.+Wang&amp;volume=21&amp;publication_year=2010&amp;pages=750-751&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B82\"><span class=\"mixed-citation\">\u6e29\u5efa\u826f\uff0c\u962e\u80dc\uff082004\uff09\u3002\u00a0<span class=\"ref-title\">\u706f\u76cf\u6ce8\u5c04\u6db2\u6cbb\u7597\u8001\u5e74\u9ad8\u8102\u8840\u75c736\u4f8b\u4e34\u5e8a\u89c2\u5bdf<\/span>\u00a0<span class=\"ref-journal\"><em>\u5e7f\u4e1c\u533b\u5b66. J\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">25<\/span>\u00a0<span class=\"ref-iss\">163<\/span>.\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Guangdong+Med.+J.&amp;title=Clinical+observation+of+36+cases+of+Erigeron+Injection+in+the+treatment+of+elderly+patients+with+hyperlipidemia.&amp;author=J.+L.+Wen&amp;author=S.+Ruan&amp;volume=25&amp;issue=163&amp;publication_year=2004&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B83\"><span class=\"mixed-citation\">\u5434\u6d9b\uff082011\uff09\u3002\u00a0<span class=\"ref-journal\"><em>\u9ec4\u916e\u82f7\u7519Apigenin-7-OpD-\u8461\u8404\u7cd6\u919b\u9178\u7684\u5168\u5408\u6210\u3002<\/em><\/span>\u00a0\u7855\u58eb\u8bba\u6587\uff0c\u6606\u660e\u7406\u5de5\u5927\u5b66\uff1b\u6606\u660e\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" 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href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Chin.+J.+New+Drugs&amp;title=Efficacy+of+compound+danshen+drop+pill+in+42+patients+with+early+acute+myocardial+infarction.&amp;author=L.+I.+Xu-Feng&amp;author=F.+Liu&amp;author=T.+L.+Jiang&amp;author=Z.+J.+Wang&amp;author=Y.+H.+Han&amp;volume=18&amp;publication_year=2010&amp;pages=1699-1702&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B86\"><span class=\"mixed-citation\">\u4e25\u4e3d\uff0c\u9ec4\u8f89\uff0c\u5510\u5e86\u5f81\uff0c\u6731\u4e3d\u534e\uff0c\u738b\u4e3d\uff0c\u5218\u6210\uff0c\u7b49\u3002 \uff082010\uff09\u3002\u00a0<span class=\"ref-title\">\u706f\u76cf\u82b1\u7d20\u901a\u8fc7\u963b\u65ad PKC-\u03b1 \u4f9d\u8d56\u6027\u4fe1\u53f7\u4f20\u5bfc\u6765\u9884\u9632\u5fc3\u810f\u80a5\u5927\u3002<\/span>\u00a0<span 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class=\"mixed-citation\">\u6768\u6587\uff0c\u7a0b\u8f89\uff0c\u8c22\u7389\u660e\uff0c\u6768\u8f89\uff0c\u5e84\u8273\uff082012\uff09\u3002\u00a0<span class=\"ref-title\">\u706f\u76cf\u7ec6\u8f9b\u6ce8\u5c04\u6db2\u5728\u4e34\u5e8a\u4e2d\u4f7f\u7528\u57fa\u4e8e\u771f\u5b9e\u4e16\u754c\u6570\u636e\u5e93\u7684\u7279\u5f81\u5206\u6790\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u4e2d\u56fdJ. Chin.\u9a6c\u7279\u3002\u533b\u5b66\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">37<\/span>\u00a02718\u20132722\u3002 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23285918\">\u8003\u7814<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=China+J.+Chin.+Mater.+Med.&amp;title=Dengzhanxixin+injection+using+character+analysis+in+clinical+based+on+real+world+his+database.&amp;author=W.+Yang&amp;author=H.+Cheng&amp;author=Y.+M.+Xie&amp;author=H.+Yang&amp;author=Y.+Zhuang&amp;volume=37&amp;publication_year=2012&amp;pages=2718-2722&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B89\"><span class=\"mixed-citation\">\u6768X.\uff0c\u718aX.\uff0c\u738b\u534e\uff0c\u738bJ.(2014)\u3002\u00a0<span class=\"ref-title\">\u4e09\u4e03\u7682\u82f7\u5bf9\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u4fdd\u62a4\u4f5c\u7528\uff1a\u5b9e\u9a8c\u7814\u7a76\u7684\u7efc\u5408\u6982\u8ff0\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u8bc1\u636e\u786e\u51ff\u3002\u57fa\u7840\u8865\u8bed\u3002\u66ff\u4ee3\u3002\u533b\u5b66\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">2014<\/span>:<span class=\"ref-iss\">204840<\/span>\u00a010.1155\/2014\/204840\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4131460\/\">PMC \u514d\u8d39\u6587\u7ae0<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25152758\">\u8003\u7814<\/a>] [<a href=\"https:\/\/doi.org\/10.1155%2F2014%2F204840\" target=\"_blank\" rel=\"noopener noreferrer\">\u4ea4\u53c9\u5f15\u7528<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Evid.+Based+Complement.+Alternat.+Med.&amp;title=Protective+effects+of+panax+notoginseng+saponins+on+cardiovascular+diseases:+a+comprehensive+overview+of+experimental+studies.&amp;author=X.+Yang&amp;author=X.+Xiong&amp;author=H.+Wang&amp;author=J.+Wang&amp;volume=2014&amp;issue=204840&amp;publication_year=2014&amp;doi=10.1155\/2014\/204840&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B90\"><span class=\"mixed-citation\">\u4f59\u8f89\uff0c\u5f20\u8f89\uff0c\u8d75\u4f1f\uff0c\u90ed\u7acb\uff0c\u674eX\uff0c\u674eY\uff0c\u7b49\u3002 \uff082016\uff09\u3002\u00a0<span class=\"ref-title\">\u7ede\u80a1\u84dd\u7682\u82f7\u901a\u8fc7\u6291\u5236chop\u901a\u8def\u548c\u6fc0\u6d3bpi3k\/akt\u901a\u8def\u6291\u5236\u5fc3\u808c\u7ec6\u80de\u51cb\u4ea1\uff0c\u4ece\u800c\u9884\u9632\u5fc3\u808c\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u00a0<em>\u4f53\u5185<\/em>\u00a0\u548c\u00a0<em>\u4f53\u5916<\/em>.<\/span>\u00a0<span class=\"ref-journal\"><em>\u7ec6\u80de\u3002\u751f\u7406\u5b66\u3002\u751f\u7269\u5316\u5b66\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">39<\/span>\u00a0123\u2013136\u3002 10.1159\/000445611 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27322831\">\u8003\u7814<\/a>] [<a href=\"https:\/\/doi.org\/10.1159%2F000445611\" target=\"_blank\" rel=\"noopener noreferrer\">\u4ea4\u53c9\u5f15\u7528<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Cell.+Physiol.+Biochem.&amp;title=Gypenoside+protects+against+myocardial+ischemia-reperfusion+injury+by+inhibiting+cardiomyocytes+apoptosis+via+inhibition+of+chop+pathway+and+activation+of+pi3k\/akt+pathway+in+vivo+and+in+vitro.&amp;author=H.+Yu&amp;author=H.+Zhang&amp;author=W.+Zhao&amp;author=L.+Guo&amp;author=X.+Li&amp;volume=39&amp;publication_year=2016&amp;pages=123-136&amp;pmid=27322831&amp;doi=10.1159\/000445611&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B91\"><span class=\"mixed-citation\">\u4e8eXP (2011)\u3002\u00a0<span class=\"ref-title\">\u706f\u76cf\u82b1\u7d20\u6ce8\u5c04\u6db2\u6cbb\u7597\u9ad8\u8102\u8840\u75c7\u7684\u7597\u6548\u53ca\u673a\u5236\u7814\u7a76<\/span>\u00a0<span class=\"ref-journal\"><em>\u7ec3\u4e60\u3002\u4e34\u5e8a\u3002 J. \u6574\u5408\u3002\u4f20\u7edf\u3002\u4e0b\u5df4\u3002\u897f\u65b9\u3002\u533b\u5b66\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">11<\/span>\u00a020-21\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Pract.+Clin.+J.+Integr.+Tradit.+Chin.+West.+Med.&amp;title=Study+on+effect+of+breviscapine+injection+in+the+treatment+of+patients+with+hyperlipidemia+and+its+mechanism.&amp;author=X.+P.+Yu&amp;volume=11&amp;publication_year=2011&amp;pages=20-21&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B92\"><span class=\"mixed-citation\">\u4e91\u5357\u836f\u7269\u7814\u7a76\u6240(1976)\u3002\u00a0<span class=\"ref-title\">\u5316\u5b66\u6210\u5206\u7814\u7a76\u00a0<em>\u706f\u76cf\u82b1<\/em>.<\/span>\u00a0<span class=\"ref-journal\"><em>\u4e0b\u5df4\u3002\u4f20\u7edf\u3002\u8349\u836f<\/em><\/span>\u00a0<span class=\"ref-vol\">11<\/span>\u00a011-14\u3002\u4e91\u5357\u836f\u7269\u7814\u7a76\u6240\u6240\u957f\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Chin.+Tradit.+Herbal+Drugs&amp;title=Study+on+the+chemical+constituents+of+Erigeron+breviscapus.&amp;volume=11&amp;publication_year=1976&amp;pages=11-14&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B93\"><span class=\"mixed-citation\">\u5f20\u5cf0\uff082014\uff09\u3002\u00a0<span class=\"ref-title\">\u706f\u76cf\u82b1\u7d20\u5bf9\u5c04\u8840\u5206\u6570\u6b63\u5e38\u5fc3\u529b\u8870\u7aed\u60a3\u8005\u7684\u5f71\u54cd\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u5e7f\u4e1c\u533b\u5b66. J\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">35<\/span>\u00a03254\u20133256\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Guangdong+Med.+J.&amp;title=The+effect+of+breviscapine+on+heart+failure+patients+with+normal+ejection+fraction.&amp;author=F.+Zhang&amp;volume=35&amp;publication_year=2014&amp;pages=3254-3256&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B94\"><span class=\"mixed-citation\">\u5f20\u7ea2\uff0c\u738b\u96ea\u6885\uff0c\u5218\u71d5\uff0c\u67f4\u4e3d\u6676\uff0c\u738b\u7ea2\uff0c\u5f20\u5b9d\u4e50\uff0c\u7b49\u3002 \uff082009\uff09\u3002\u00a0<span class=\"ref-title\">\u706f\u76cf\u7ec6\u8f9b\u6ce8\u5c04\u6db2\u5bf9\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u8bf1\u5bfc\u7684\u5927\u9f20\u5fc3\u810f\u5fae\u8840\u7ba1\u7ec6\u80de\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u4ea7\u751f\u7684\u5f71\u54cd<\/span>\u00a0<span class=\"ref-journal\"><em>J\u00b7\u94a6.\u533b\u836f\u3002\u79d1\u5b66\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">44<\/span>\u00a01791\u20131795\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.+Chin.+Pharm.+Sci.&amp;title=Effects+of+dengzhan+xixin+injection+on+inflammatory+cytokine+production+in+rat+cardiac+microvascular+cells+induced+by+tumor+necrosis+factor.&amp;author=H.+Zhang&amp;author=X.+Y.+Wang&amp;author=Y.+Liu&amp;author=L.+J.+Chai&amp;author=H.+Wang&amp;volume=44&amp;publication_year=2009&amp;pages=1791-1795&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B95\"><span class=\"mixed-citation\">\u5f20\u5e86\u660e\uff0c\u5f20\u98de\u9f99 (2012)\u3002\u00a0<span class=\"ref-title\">\u706f\u76cf\u82b1\u7d20\u7c89\u6ce8\u5c04\u6db2\u6cbb\u7597\u51a0\u5fc3\u75c5\u5fc3\u8111\u8840\u7ba1\u75c5\u7684\u4e34\u5e8a\u89c2\u5bdf<\/span>\u00a0<span class=\"ref-journal\"><em>\u5929\u6d25\u4e2d\u533b\u6742\u5fd7.\u4e0b\u5df4\u3002\u533b\u5b66\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">29<\/span>\u00a0133\u2013135\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Tianjin+J.+Tradit.+Chin.+Med.&amp;title=Clinical+observation+on+the+curative+effect+of+breviscapine+powder+injection+in+treating+heart+stroke+of+coronary+heart+disease.&amp;author=Q.+M.+Zhang&amp;author=F.+L.+Zhang&amp;volume=29&amp;publication_year=2012&amp;pages=133-135&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B96\"><span class=\"mixed-citation\">\u5f20\u6587\u8363\uff0c\u5f20\u6c38\u6797\uff0c\u738b\u6d4e\u751f\uff0c\u6797YY\uff0c\u5c1aB.(1988)\u3002\u00a0<span class=\"ref-title\">\u84ec\u84ec\u4e2d\u9ec4\u916e\u7c7b\u5316\u5408\u7269\u7684\u5206\u79bb\u4e0e\u9274\u5b9a<em>\u706f\u76cf\u82b1<\/em>).<\/span>\u00a0<span class=\"ref-journal\"><em>\u4e0b\u5df4\u3002\u4f20\u7edf\u3002\u8349\u836f<\/em><\/span>\u00a0<span class=\"ref-vol\">19<\/span>:<span class=\"ref-iss\">7<\/span>.\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Chin.+Tradit.+Herb+Drugs&amp;title=Isolation+and+identification+of+flavonoids+from+shortscape+fleabane+(Erigeron+breviscapus).&amp;author=R.+W.+Zhang&amp;author=Y.+L.+Zhang&amp;author=J.+S.+Wang&amp;author=Y.+Y.+Lin&amp;author=B.+Shang&amp;volume=19&amp;issue=7&amp;publication_year=1988&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B97\"><span class=\"mixed-citation\">\u5f20S.\uff0c\u5218JY\uff0c\u8d75L.\uff0c\u96f7K.\uff0c\u5218Y.\uff082016\uff09\u3002\u00a0<span class=\"ref-title\">\u706f\u76cf\u82b1\u6ce8\u5c04\u6db2\u5f15\u8d77\u836f\u54c1\u4e0d\u826f\u53cd\u5e94204\u4f8b\u5206\u6790<\/span>\u00a0<span class=\"ref-journal\"><em>\u4e0b\u5df4\u3002 J.\u970d\u65af\u666e\u3002\u533b\u836f\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">36<\/span>\u00a01585\u20131588\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Chin.+J.+Hosp.+Pharm.&amp;title=Analysis+of+204+cases+of+adverse+drug+reactions+caused+by+breviscapine+injection.&amp;author=S.+Zhang&amp;author=J.+Y.+Liu&amp;author=L.+Zhao&amp;author=K.+Lei&amp;author=Y.+Liu&amp;volume=36&amp;publication_year=2016&amp;pages=1585-1588&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B98\"><span class=\"mixed-citation\">\u5f20\u7389\u534e\uff082014\uff09\u3002\u00a0<span class=\"ref-title\">\u7a33\u5fc3\u9897\u7c92\u8054\u5408\u7f8e\u6258\u6d1b\u5c14\u5bf9PCI\u672f\u540e\u91cd\u5927\u5fc3\u8840\u7ba1\u6025\u6027\u5fc3\u808c\u6897\u6b7b\u7684\u5f71\u54cd<\/span>\u00a0<span class=\"ref-journal\"><em>\u4e0b\u5df4\u3002 J. \u6574\u5408\u3002\u533b\u5b66\u3002\u5fc3\u810f\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">12<\/span>\u00a0180\u2013182\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Chin.+J.+Integr.+Med.+Cardiol.&amp;title=Effect+of+Wenxin+Granule+combined+with+metoprolol+on+major+cardiovascular+acute+myocardial+infarction+after+PCI.&amp;author=Y.+H.+Zhang&amp;volume=12&amp;publication_year=2014&amp;pages=180-182&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B99\"><span class=\"mixed-citation\">\u8d75\u521a. (2010).\u00a0<span class=\"ref-title\">\u706f\u76cf\u82b1\u7d20\u8054\u5408\u7f3a\u8840\/\u9884\u5904\u7406\u5bf9\u5bb6\u5154\u5fc3\u808c\u7f3a\u8840\/\u518d\u704c\u6ce8\u65f6\u5fc3\u808c\u86cb\u767d\u80bf\u7624\u574f\u6b7b\u56e0\u5b50-\u03b1\u3001\u6838\u56e0\u5b50-\u03bab\u8868\u8fbe\u5f71\u54cd\u7684\u5b9e\u9a8c\u7814\u7a76<\/span>\u00a0<span class=\"ref-journal\"><em>J.\u514b\u6797\u3002\u5fc3\u810f\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">8<\/span>\u00a0631\u2013634\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.+Clin.+Cardiol.&amp;title=Experimental+study+of+effect+of+combining+breviscapine+with+ischemic\/preconditioning+on+the+expression+of+myocardial+protein+tumor+necrosis+factor-%CE%B1,+nuclear+factor-kappa+b+during+myocardial+ischemia\/reperfusion+in+rabbits.&amp;author=G.+Zhao&amp;volume=8&amp;publication_year=2010&amp;pages=631-634&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B100\"><span class=\"mixed-citation\">\u8d75ZG\uff0c\u9ad8HC\uff0c\u738bAG\uff082008\uff09\u3002\u00a0<span class=\"ref-journal\"><em>\u6ce8\u5c04\u5242\u7684\u4e34\u5e8a\u5b89\u5168\u6027\u4e0e\u5408\u7406\u5e94\u7528\u3002<\/em><\/span>\u00a0\u5317\u4eac\uff1a\u5316\u5b66\u5de5\u4e1a\u51fa\u7248\u793e\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Clinical+Safety+and+Rational+Application+of+Injection.&amp;author=Z.+G.+Zhao&amp;author=H.+C.+Gao&amp;author=A.+G.+Wang&amp;publication_year=2008&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B101\"><span class=\"mixed-citation\">\u90d1\u6210\uff0c\u6b27\u4f1f\uff0c\u6c89\u534e\uff0c\u5468\u5b50\uff0c\u738b\u5065\uff082015\uff09\u3002\u00a0<span class=\"ref-title\">\u706f\u76cf\u82b1\u7d20\u548c\u7532\u94b4\u80fa\u8054\u5408\u6cbb\u7597\u7cd6\u5c3f\u75c5\u5468\u56f4\u795e\u7ecf\u75c5\u53d8\uff1a\u4e2d\u56fd\u7814\u7a76\u7684\u7cfb\u7edf\u8bc4\u4ef7\u548c\u835f\u8403\u5206\u6790\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u751f\u7269\u533b\u5b66\u3002\u8d44\u6e90\u3002\u56fd\u9645\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">2015<\/span>:<span class=\"ref-iss\">680756<\/span>\u00a010.1155\/2015\/680756\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4383387\/\">PMC \u514d\u8d39\u6587\u7ae0<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25866802\">\u8003\u7814<\/a>] [<a href=\"https:\/\/doi.org\/10.1155%2F2015%2F680756\" target=\"_blank\" rel=\"noopener noreferrer\">\u4ea4\u53c9\u5f15\u7528<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Biomed.+Res.+Int.&amp;title=Combined+therapy+of+diabetic+peripheral+neuropathy+with+breviscapine+and+mecobalamin:+a+systematic+review+and+a+meta-analysis+of+Chinese+studies.&amp;author=C.+Zheng&amp;author=W.+Ou&amp;author=H.+Shen&amp;author=Z.+Zhou&amp;author=J.+Wang&amp;volume=2015&amp;issue=680756&amp;publication_year=2015&amp;doi=10.1155\/2015\/680756&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B102\"><span class=\"mixed-citation\">\u90d1\u521a\uff0c\u8463\u5b87\uff0c\u6881\u5b87\uff081998\uff09\u3002\u00a0<span class=\"ref-title\">\u706f\u76cf\u82b1\u7d20\u5bf9\u79bb\u4f53\u5927\u9f20\u80f8\u4e3b\u52a8\u8109\u73af\u7684\u5f71\u54cd\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u4e0b\u5df4\u3002\u4f20\u7edf\u3002\u8349\u836f<\/em><\/span>\u00a0<span class=\"ref-vol\">10<\/span>\u00a0680\u2013683\u3002\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Chin.+Tradit.+Herbal+Drugs&amp;title=Effects+of+breviscapine+on+isolated+rat+thoracic+aortic+ring.&amp;author=G.+Zheng&amp;author=Y.+Dong&amp;author=Y.+Liang&amp;volume=10&amp;publication_year=1998&amp;pages=680-683&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B103\"><span class=\"mixed-citation\">\u949f\u534e\uff0c\u9093\u52c7\uff0c\u738b\u65ed\uff0c\u6768\u6ce2\uff082005\uff09\u3002\u00a0<span class=\"ref-title\">\u7528\u4e8e\u6301\u7eed\u9012\u9001\u706f\u76cf\u82b1\u7d20\u7684\u591a\u56ca\u8102\u8d28\u4f53\u5236\u5242\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u56fd\u9645\u3002 J.Pharm\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">301<\/span>\u00a015-24\u3002 10.1016\/j.ijpharm.2005.04.001 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16023316\">\u8003\u7814<\/a>] [<a href=\"https:\/\/doi.org\/10.1016%2Fj.ijpharm.2005.04.001\" target=\"_blank\" rel=\"noopener noreferrer\">\u4ea4\u53c9\u5f15\u7528<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Int.+J.+Pharm.&amp;title=Multivesicular+liposome+formulation+for+the+sustained+delivery+of+breviscapine.&amp;author=H.+Zhong&amp;author=Y.+Deng&amp;author=X.+Wang&amp;author=B.+Yang&amp;volume=301&amp;publication_year=2005&amp;pages=15-24&amp;pmid=16023316&amp;doi=10.1016\/j.ijpharm.2005.04.001&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B104\"><span class=\"mixed-citation\">\u5468H.\uff0c\u9648X.\uff0c\u9648L.\uff0c\u5468X.\uff0c\u90d1G.\uff0c\u5f20H.\uff0c\u7b49\u3002 \uff082014\uff09\u3002\u00a0<span class=\"ref-title\">\u706f\u76cf\u4e59\u7d20\u901a\u8fc7\u6291\u5236\u5185\u76ae-\u95f4\u8d28\u8f6c\u5316\u5bf9\u5f02\u4e19\u80be\u4e0a\u817a\u7d20\u8bf1\u5bfc\u7684\u5927\u9f20\u5fc3\u808c\u7ea4\u7ef4\u5316\u7684\u6297\u7ea4\u7ef4\u5316\u4f5c\u7528\u3002<\/span>\u00a0<span class=\"ref-journal\"><em>\u5206\u5b50<\/em><\/span>\u00a0<span class=\"ref-vol\">19<\/span>\u00a015611\u201315623\u3002 10.3390\/\u5206\u5b50191015611\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6271942\/\">PMC \u514d\u8d39\u6587\u7ae0<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25268717\">\u8003\u7814<\/a>] [<a href=\"https:\/\/doi.org\/10.3390%2Fmolecules191015611\" target=\"_blank\" rel=\"noopener noreferrer\">\u4ea4\u53c9\u5f15\u7528<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Molecules&amp;title=Anti-fibrosis+effect+of+scutellarin+via+inhibition+of+endothelial-mesenchymal+transition+on+isoprenaline-induced+myocardial+fibrosis+in+rats.&amp;author=H.+Zhou&amp;author=X.+Chen&amp;author=L.+Chen&amp;author=X.+Zhou&amp;author=G.+Zheng&amp;volume=19&amp;publication_year=2014&amp;pages=15611-15623&amp;pmid=25268717&amp;doi=10.3390\/molecules191015611&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B105\"><span class=\"mixed-citation\">\u5468\u5e86\u751f\uff0c\u8d75\u6c38\u660e\uff0c\u767d\u971e\uff0c\u674e\u9e4f\u661f\uff0c\u962e\u957f\u5149\uff081992\uff09\u3002\u00a0<span class=\"ref-title\">\u65b0\u706f\u76cf\u82b1\u7d20\u5bf9\u4eba\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7ea4\u6eb6\u53ca\u6297\u51dd\u4f5c\u7528\u7684\u5f71\u54cd<\/span>\u00a0<span class=\"ref-journal\"><em>\u836f\u7406\u5b66\u5b66\u62a5\u3002\u7f6a\u3002<\/em><\/span>\u00a0<span class=\"ref-vol\">13<\/span>\u00a0239\u2013242\u3002 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/1332421\">\u8003\u7814<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Acta+Pharmacol.+Sin.&amp;title=Effect+of+new-breviscapine+on+fibrinolysis+and+anticoagulation+of+human+vascular+endothelial+cells.&amp;author=Q.+S.+Zhou&amp;author=Y.+M.+Zhao&amp;author=X.+Bai&amp;author=P.+X.+Li&amp;author=C.+G.+Ruan&amp;volume=13&amp;publication_year=1992&amp;pages=239-242&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<\/ol>\n<\/div>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5441392\/#:~:text=A%20meta,2012\">\u6765\u6e90<\/a><\/p>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Breviscapine is a crude extract of several flavonoids of Erigeron breviscapus (Vant.) Hand.-Mazz., containing more than 85% of scutellarin, which has been traditionally used in China as an activating blood circulation medicine to improve cerebral blood supply.<\/p>","protected":false},"author":1,"featured_media":5374,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9],"tags":[],"class_list":["post-5081","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-supplements"],"_links":{"self":[{"href":"https:\/\/directcm.com\/zh\/wp-json\/wp\/v2\/posts\/5081","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/directcm.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/directcm.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/directcm.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/directcm.com\/zh\/wp-json\/wp\/v2\/comments?post=5081"}],"version-history":[{"count":1,"href":"https:\/\/directcm.com\/zh\/wp-json\/wp\/v2\/posts\/5081\/revisions"}],"predecessor-version":[{"id":5396,"href":"https:\/\/directcm.com\/zh\/wp-json\/wp\/v2\/posts\/5081\/revisions\/5396"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/directcm.com\/zh\/wp-json\/wp\/v2\/media\/5374"}],"wp:attachment":[{"href":"https:\/\/directcm.com\/zh\/wp-json\/wp\/v2\/media?parent=5081"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/directcm.com\/zh\/wp-json\/wp\/v2\/categories?post=5081"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/directcm.com\/zh\/wp-json\/wp\/v2\/tags?post=5081"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}