{"id":5097,"date":"2024-01-15T12:23:02","date_gmt":"2024-01-15T12:23:02","guid":{"rendered":"https:\/\/farlong.com\/?p=5097"},"modified":"2024-01-27T10:21:00","modified_gmt":"2024-01-27T10:21:00","slug":"optimization-of-quercitrin-and-total-flavonoids-extraction-from-herba-polygoni-capitati-by-response-surface-methodology","status":"publish","type":"post","link":"https:\/\/directcm.com\/zh\/optimization-of-quercitrin-and-total-flavonoids-extraction-from-herba-polygoni-capitati-by-response-surface-methodology\/","title":{"rendered":"\u54cd\u5e94\u9762\u6cd5\u4f18\u5316\u5934\u9996\u8349\u4e2d\u69f2\u76ae\u82f7\u548c\u603b\u9ec4\u916e\u7684\u63d0\u53d6\u5de5\u827a"},"content":{"rendered":"
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\u91c7\u7528\u54cd\u5e94\u9762\u6cd5\uff08RSM\uff09\u4f18\u5316\u5934\u82b1\u5bee\u4e2d\u69f2\u76ae\u82f7\u548c\u603b\u9ec4\u916e\uff08TF\uff09\u7684\u63d0\u53d6\u6761\u4ef6\u3002<\/p>\n<\/div>\n

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\u91c7\u7528\u4e2d\u5fc3\u590d\u5408\u8bbe\u8ba1\uff08CCD\uff09\u6765\u7814\u7a76\u4e09\u4e2a\u81ea\u53d8\u91cf\uff0c\u5305\u62ec\u6eb6\u5242\u7ec4\u6210\uff08%\uff09\u3001\u6eb6\u5242\u6750\u6599\u6bd4\uff08ml\/g\uff09\u548c\u63d0\u53d6\u65f6\u95f4\uff08min\uff09\u5bf9\u54cd\u5e94\u3001\u69f2\u76ae\u82f7\u548cTF\u4ea7\u91cf\u7684\u5f71\u54cd\u3002<\/p>\n<\/div>\n

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\u6700\u4f73\u63d0\u53d6\u6761\u4ef6\u4e3a\uff1a\u4e59\u9187\u6d53\u5ea665.63%\uff1b\u6eb6\u5242-\u7269\u6599\u6bd4\uff0c10.55:1(ml\/g)\uff1b\u63d0\u53d6\u65f6\u95f4\uff0c54.33 \u5206\u949f\u3002\u5efa\u7acb\u7684\u6570\u5b66\u6a21\u578b\u5f88\u597d\u5730\u63cf\u8ff0\u4e86\u5b9e\u9a8c\u53c2\u6570\u7684\u56e0\u7d20\uff0c\u5e76\u4e3a\u69f2\u76ae\u82f7\u548cTF\u7684\u6700\u4f73\u4ea7\u7387\u63d0\u4f9b\u4e86\u7edf\u8ba1\u4e0a\u51c6\u786e\u7684\u9884\u6d4b\u3002<\/p>\n<\/div>\n

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\u5b9e\u9a8c\u503c\u4e0e\u6240\u5efa\u7acb\u7684\u6570\u5b66\u6a21\u578b\u9884\u6d4b\u503c\u4e00\u81f4\uff0c\u8868\u660e\u6240\u7528\u6a21\u578b\u7684\u9002\u7528\u6027\u4ee5\u53caRSM\u5728\u4f18\u5316\u63d0\u53d6\u6761\u4ef6\u65b9\u9762\u7684\u6210\u529f\u3002<\/p>\n<\/div>\n<\/div>\n

\u5173\u952e\u8bcd\uff1a\u00a0<\/strong>\u4e2d\u5fc3\u590d\u5408\u8bbe\u8ba1\u3001\u63d0\u53d6\u3001\u84fc\u3001\u4f18\u5316\u3001\u54cd\u5e94\u9762\u6cd5<\/span><\/div>\n
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\u84fc\u8349\uff08Herba Polygoni Capitati\uff09\u7684\u5730\u4e0a\u90e8\u5206\u6216\u5168\u8349\u00a0\u5934\u82b1\u84fc<\/em>\u00a0\u5e03\u8d6b-\u706b\u817f\u3002 ex D. Don\uff0c\u5728\u4e2d\u56fd\uff0c\u7279\u522b\u662f\u5728\u4e00\u4e9b\u5c11\u6570\u6c11\u65cf\u5730\u533a\uff0c\u957f\u671f\u4ee5\u6765\u4e00\u76f4\u88ab\u7528\u4f5c\u4f20\u7edf\u4e2d\u836f\uff08TCM\uff09\u4e4b\u4e00\u3002\u7ecf\u9274\u5b9a\uff0c\u5934\u9996\u8349\u7684\u6d3b\u6027\u5316\u5b66\u6210\u5206\u4e3a\u9ec4\u916e\u7c7b\u3001\u915a\u9178\u7c7b\u548c\u5355\u5b81\u7c7b\uff0c[1<\/a>,2<\/a>,3<\/a>] \u5176\u4e2d\u7c7b\u9ec4\u916e\u88ab\u8ba4\u4e3a\u662f\u4e3b\u8981\u7684\u751f\u7269\u6d3b\u6027\u5316\u5408\u7269\u3002\u836f\u7406\u548c\u4e34\u5e8a\u7814\u7a76\u8868\u660e\u69f2\u76ae\u7d20\u53ca\u5176\u82f7\u7c7b\u662f\u5177\u6709\u6297\u764c\u4f5c\u7528\u7684\u751f\u7269\u6d3b\u6027\u5316\u5408\u7269\u30024<\/a>,5<\/a>] \u6297\u6c27\u5316[6<\/a>,7<\/a>] \u548c\u9176\u8c03\u8282\u6d3b\u6027\u3002[8<\/a>,9<\/a>,10<\/a>] \u6d41\u884c\u75c5\u5b66\u7814\u7a76\u8fd8\u8868\u660e\uff0c\u5927\u91cf\u6444\u5165\u9ec4\u916e\u7c7b\u5316\u5408\u7269\uff08\u4e3b\u8981\u662f\u69f2\u76ae\u7d20\uff09\u4e0e\u5fc3\u8840\u7ba1\u75be\u75c5\u4e4b\u95f4\u5448\u53cd\u6bd4\u5173\u7cfb\u3002[11<\/a>]<\/p>\n

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\u5728\u5934\u84fc\u4e2d\u5b58\u5728\u7684\u6240\u6709\u5316\u5408\u7269\u4e2d\uff0c\u915a\u9178\u548c\u9ec4\u916e\u7c7b\u6210\u5206\u6700\u53d7\u5173\u6ce8\uff0c\u5e76\u88ab\u8ba4\u4e3a\u5bf9\u5176\u836f\u7406\u4f5c\u7528\u975e\u5e38\u91cd\u8981\u300217<\/a>] \u4ec5\u4ee5\u4e00\u6b21\u4e00\u56e0\u5b50\u7684\u65b9\u6cd5\u4ece\u5934\u72b6\u8349\u4e2d\u63d0\u53d6\u6ca1\u98df\u5b50\u9178 (GA) \u6216 TF\uff0c[18<\/a>] \u6216\u4e0e\u6b63\u4ea4\u8bbe\u8ba1\u76f8\u5173\uff0c[19<\/a>] \u6b64\u524d\u5df2\u62a5\u9053\u8fc7\u3002\u4e00\u6b21\u53ea\u6709\u4e00\u4e2a\u56e0\u7d20\u7684\u65b9\u6cd5\uff0c\u5176\u4e2d\u4e00\u6b21\u53ea\u6709\u4e00\u4e2a\u56e0\u7d20\u662f\u53ef\u53d8\u7684\uff0c\u540c\u65f6\u4fdd\u6301\u6240\u6709\u5176\u4ed6\u56e0\u7d20\u4e0d\u53d8\uff0c[20<\/a>] \u975e\u5e38\u8017\u65f6\uff0c\u5e76\u4e14\u53ef\u80fd\u4f1a\u5bfc\u81f4\u8bef\u5bfc\u6027\u7684\u7ed3\u8bba\uff0c\u56e0\u4e3a\u5b83\u4e0d\u5305\u62ec\u56e0\u7d20\u4e4b\u95f4\u7684\u4ea4\u4e92\u4f5c\u7528\u3002\u6b63\u4ea4\u8bbe\u8ba1\u5728\u6d4b\u8bd5\u8bbe\u8ba1\u4e2d\u5f88\u6709\u7528[21<\/a>] \u4f46\u5b83\u4e0d\u63d0\u4f9b\u6a21\u578b\u65b9\u7a0b\u7684\u9884\u6d4b\u3002\u54cd\u5e94\u9762\u65b9\u6cd5 (RSM) \u662f\u7edf\u8ba1\u548c\u6570\u5b66\u6280\u672f\u7684\u96c6\u5408\uff0c\u53ef\u4ee5\u514b\u670d\u8fd9\u4e9b\u7f3a\u70b9\uff0c\u56e0\u4e3a\u5b83\u8003\u8651\u4e86\u53d8\u91cf\u4e4b\u95f4\u53ef\u80fd\u7684\u76f8\u4e92\u4f5c\u7528\u6548\u5e94\u300222<\/a>,23<\/a>] \u901a\u8fc7RSM\u53ef\u4ee5\u5f97\u5230\u54cd\u5e94\u4f5c\u4e3a\u72ec\u7acb\u53c2\u6570\u51fd\u6570\u7684\u54cd\u5e94\u66f2\u9762\u56fe\u548c\u7b49\u503c\u7ebf\u56fe\u3002[24<\/a>] \u5728\u672c\u7814\u7a76\u4e2d\uff0c\u91c7\u7528RSM\u65b9\u6cd5\u6765\u4f18\u5316\u5934\u82b1\u8349\u7684\u63d0\u53d6\u6761\u4ef6\uff08\u6eb6\u5242\u6bd4\u4f8b\u3001\u6eb6\u5242\u6750\u6599\u6bd4\u3001\u63d0\u53d6\u65f6\u95f4\u7b49\uff09\uff0c\u4ee5\u540c\u65f6\u6700\u5927\u5316\u69f2\u76ae\u7d20\u548cTF\u7684\u4ea7\u91cf\u3002<\/p>\n

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\u53bb\uff1a<\/a><\/div>\n

\u6750\u6599\u548c\u65b9\u6cd5<\/h2>\n

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\u6750\u6599\u548c\u5316\u5b66\u54c1<\/h3>\n

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\u5934\u84fc\u7ecf\u9648\u5fb7\u6e90\u6559\u6388\u690d\u7269\u5b66\u9274\u5b9a\uff0c\u8d2d\u81ea\u4e2d\u56fd\u8d35\u5dde\u8d35\u5dde\u6c83\u66fc\u836f\u4e1a\u516c\u53f8\u3002\u5c06\u5934\u9996\u8349\u5168\u8349\u5728\u5f3a\u5236\u5bf9\u6d41\u901a\u7528\u70d8\u7bb1\uff08101-2AB Taijin\uff0c\u4e2d\u56fd\uff09\u4e2d\u4e8e 50\u00b0C \u5e72\u71e5 4 \u5c0f\u65f6\u3002\u5c06\u5e72\u71e5\u540e\u7684\u6837\u54c1\u5728\u65cb\u8f6c\u78e8\u673a\uff08DFY-200\u6e29\u5cad\uff0c\u4e2d\u56fd\uff09\u4e2d\u7814\u78e8\u5e76\u8fc7\u7b5b\u7c89\u672b\u3002\u6536\u96c6\u5c3a\u5bf8\u5728 10 \u81f3 40 \u76ee\uff080.3~2mm\uff0c\u5185\u5f84\uff09\u4e4b\u95f4\u7684\u9897\u7c92\u7528\u4e8e\u7814\u7a76\u3002\u53c2\u8003\u5316\u5408\u7269\u69f2\u76ae\u82f7\uff08111538-200403\uff09\u548c\u82a6\u4e01\uff08080-9303\uff09\u8d2d\u81ea\u4e2d\u56fd\u751f\u7269\u5236\u54c1\u68c0\u5b9a\u6240\uff08\u4e2d\u56fd\u5317\u4eac\uff09\u3002\u4e59\u8148\u548c\u7532\u9187\u4e3a HPLC \u7ea7\uff08Tedia\uff0c\u7f8e\u56fd\uff09\u3002\u6c34\u4e3a\u4e50\u767e\u6c0f\u996e\u7528\u7eaf\u51c0\u6c34\uff08\u5e7f\u4e1c\u4e50\u767e\u4ed5\u98df\u54c1\u996e\u6599\u6709\u9650\u516c\u53f8\uff09\u3002\u7532\u9178\u4e3a MS \u7ea7\uff08Roe Scientific Inc\uff0c\u7f8e\u56fd\uff09\u3002\u6240\u6709\u5176\u4ed6\u5316\u5b66\u54c1\u548c\u6eb6\u5242\u5747\u4e3a\u5206\u6790\u7ea7\u4e14\u5e02\u552e\u3002<\/p>\n

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\u6837\u54c1\u5236\u5907<\/h3>\n

 <\/p>\n

\u51c6\u786e\u79f0\u53d6\u5934\u9996\u8349\u7c89\u672b2g\uff0c\u5728\u4e00\u5b9a\u6761\u4ef6\u4e0b\u63d0\u53d6\uff0c3500\u2103\u79bb\u5fc3\u3002\u00a0\u8f6c\u901f<\/em>\u00a010\u5206\u949f\u3002\u6536\u96c6\u4e0a\u6e05\u6db2\u5e76\u901a\u8fc7\u6ee4\u7eb8\u8fc7\u6ee4\u7528\u4e8e\u540e\u7eed\u5206\u6790\u3002<\/p>\n

 <\/p>\n<\/div>\n

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\u4eea\u5668<\/h3>\n

 <\/p>\n

\u672c\u7814\u7a76\u4e2d\u4f7f\u7528\u7684\u5206\u6790\u7cfb\u7edf\u5982\u4e0b\uff1a\u5728\u53cc\u5149\u675f\u5206\u5149\u5149\u5ea6\u8ba1\uff08Cary 100-Varian\uff09\u4e0a\u8bb0\u5f55\u7d2b\u5916-\u53ef\u89c1\u5149\u8c31\uff0c\u6c60\u957f\u5ea6\u4e3a 1 cm\u3002 DIONEX\/UltiMate 3000 \u7cfb\u5217 UHPLC-DAD \u7cfb\u7edf\u7531\u771f\u7a7a\u8131\u6c14\u673a\u3001\u56db\u5143\u6cf5\u3001\u81ea\u52a8\u8fdb\u6837\u5668\u3001\u6052\u6e29\u67f1\u6e29\u7bb1\u548c DAD \u68c0\u6d4b\u5668 (DIONEX, ThermoFisher, Sunnyvale, USA) \u7ec4\u6210\uff0c\u7528\u4e8e\u83b7\u53d6\u8272\u8c31\u56fe\u3002<\/p>\n

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\u603b\u9ec4\u916e\u542b\u91cf\u7684\u6d4b\u5b9a<\/h3>\n

 <\/p>\n

\u603b\u9ec4\u916e\u542b\u91cf\uff08TFC\uff09\u6309\u7167\u524d\u8ff0\u94dd\u6bd4\u8272\u6cd5\u6d4b\u5b9a[25<\/a>,26<\/a>,27<\/a>,28<\/a>] \u8fdb\u884c\u4fee\u6539\u3002\u7b80\u800c\u8a00\u4e4b\uff0c\u5c06\u6bcf\u79cd\u690d\u7269\u63d0\u53d6\u7269\u7684\u7b49\u5206\u8bd5\u6837\uff080.5ml\uff09\u4e0e 4.3ml \u76f8\u5173\u6eb6\u5242\u6df7\u5408\uff0c\u7136\u540e\u6dfb\u52a0 0.1ml 10% \u6c2f\u5316\u94dd\uff08AlCl3<\/sub>\uff09\u548c0.1ml 1M\u4e59\u9178\u94a0\uff08CH3<\/sub>\u00a0\u5e93\u7eb3\uff09\u3002\u4f7f\u7528\u82a6\u4e01\u4f5c\u4e3a\u53c2\u8003\u6807\u51c6\u3002\u5ba4\u6e29\u5b75\u80b2 30 \u5206\u949f\u540e\uff0c\u5c06\u53cd\u5e94\u6df7\u5408\u7269\u5728 405 nm \u5904\u5bf9\u7167\u7a7a\u767d\u8fdb\u884c\u6d4b\u91cf\u3002\u8ba1\u7b97\u6bcf\u4e2a\u6837\u54c1\u7684 TFC \u503c\u5e76\u8868\u793a\u4e3a\u6bcf\u514b\u5e72\u71e5\u6750\u6599 (DM) \u7684\u82a6\u4e01\u5f53\u91cf\u6beb\u514b\u6570\u3002<\/p>\n

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\u8272\u8c31\u5206\u79bb<\/h3>\n

 <\/p>\n

\u4f7f\u7528 DIONEX\/UltiMate 3000 \u7cfb\u5217\u5bf9\u63d0\u53d6\u7269\u8fdb\u884c HPLC \u5206\u6790\u3002\u5206\u79bb\u5728 ZORBAX SB-C \u4e0a\u8fdb\u884c18<\/sub>\u00a0\u8272\u8c31\u67f1\uff08150 mm \u00d7 4.6 mm\uff0c5 \u03bcm\uff1bAgilent\uff0cCA\uff0cUSA\uff09\uff0c\u6d41\u901f 1.0ml\/min\u3002\u6d41\u52a8\u76f8\u7531 A\uff08\u4e59\u8148\uff09\u548c B\uff080.2% \u7532\u9178\u6c34\u6eb6\u6db2\uff09\u7684\u7ec4\u5408\u7ec4\u6210\u3002\u7ebf\u6027\u68af\u5ea6\u4e3a\u4ece 5% \u5230 15% A (\u4f53\u79ef\/\u4f53\u79ef<\/em>\uff095\u5206\u949f\uff0c10\u5206\u949f16%A\uff0c20\u5206\u949f20%A\uff0c\u7136\u540e\u572820%A\u4fdd\u630122\u5206\u949f\u3002\u6bcf\u6b21\u8fd0\u884c\u540e\u90fd\u6709 5 \u5206\u949f\u7684\u5e73\u8861\u65f6\u95f4\u3002\u7d2b\u5916\u68c0\u6d4b\u5668\u7684\u6ce2\u957f\u8bbe\u7f6e\u4e3a260 nm\uff0c\u67f1\u6e29\u7bb1\u7684\u6e29\u5ea6\u4fdd\u6301\u572830\u2103\u3002\u6ce8\u5c04\u524d\u5bf9\u6837\u54c1\u8fdb\u884c\u8fc7\u6ee4\uff08PTFE \u6ce8\u5c04\u5668\u8fc7\u6ee4\u5668\uff1b0.45 \u03bcm\uff1bHanbon Ltd\uff0c\u4e2d\u56fd\uff1b013045\uff09\u3002\u4f7f\u7528 Chromeleon 7.1 \u8f6f\u4ef6\u6536\u96c6\u548c\u5206\u6790\u6570\u636e\u3002<\/p>\n

 <\/p>\n<\/div>\n

\n

\u6807\u51c6\u6eb6\u6db2\u7684\u5236\u5907<\/h3>\n

 <\/p>\n

\u7528\u7532\u9187\u5236\u5907\u82a6\u4e01\u548c\u69f2\u76ae\u82f7\u7684\u6807\u51c6\u50a8\u5907\u6eb6\u6db2\uff0c\u6d53\u5ea6\u5206\u522b\u4e3a 190.8 \u03bcg\/ml \u548c 106.0 \u03bcg\/ml\u3002\u5206\u522b\u6839\u636e\u5cf0\u9762\u79ef\u548c\u5438\u5149\u5ea6\u63a8\u5bfc\u7ebf\u6027\u6700\u5c0f\u4e8c\u4e58\u56de\u5f52\u65b9\u7a0b\u6821\u51c6\u69f2\u76ae\u82f7\u548cTF\u7684\u6807\u51c6\u66f2\u7ebf\uff0c\u6839\u636e\u6807\u51c6\u66f2\u7ebf\u8ba1\u7b97\u6837\u54c1\u4e2d\u69f2\u76ae\u82f7\u548cTF\u7684\u6d53\u5ea6\u3002<\/p>\n

 <\/p>\n<\/div>\n

\n

\u9009\u62e9\u5408\u9002\u7684\u63d0\u53d6\u6761\u4ef6<\/h3>\n

 <\/p>\n

\u5728\u4f7f\u7528 RSM \u5f00\u5c55\u7814\u7a76\u4e4b\u524d\uff0c\u8fdb\u884c\u4e86\u4e00\u7ec4\u521d\u6b65\u6d4b\u8bd5\u4ee5\u9009\u62e9\u76f8\u5173\u81ea\u53d8\u91cf\u5e76\u786e\u5b9a\u5176\u5b9e\u9a8c\u8303\u56f4\u3002\u521d\u6b65\u5b9e\u9a8c\u7684\u7b2c\u4e00\u6b65\u662f\u9009\u62e9\u5408\u9002\u7684\u5934\u9996\u8349\u63d0\u53d6\u65b9\u6cd5\u3002\u6d4b\u8bd5\u4e86\u4e09\u79cd\u4e0d\u540c\u7684\u65b9\u6cd5\uff0c\u5373\u6d78\u6e0d\u3001\u56de\u6d41\u548c\u8d85\u58f0\u63d0\u53d6\u3002\u521d\u6b65\u5b9e\u9a8c\u7684\u7b2c\u4e8c\u6b65\u662f\u9009\u62e9\u5408\u9002\u7684\u9996\u4e4c\u63d0\u53d6\u6eb6\u5242\u3002\u4f7f\u75280-100%\u8303\u56f4\u5185\u7684\u4e00\u7cfb\u5217\u8403\u53d6\u6eb6\u5242\uff08\u4e59\u9187\u6216\u7532\u9187\u6c34\u6eb6\u6db2\uff09\uff0c\u786e\u5b9a\u6700\u4f73\u6eb6\u5242\u3002\u4e09\u3001\u6eb6\u5242\u4e0e\u7269\u6599\u6bd4\u7684\u56e0\u7d20\uff086:1\u30018:1\u300110:1\u300112:1\u300114:1\uff1b\u00a0\u4f53\u79ef\/\u7c73<\/em>\uff09\u4f7f\u7528\u4e59\u9187\uff1a\u6c34\uff0870\uff1a30\uff0c\u00a0\u4f53\u79ef\/\u4f53\u79ef<\/em>\uff09\u4e3a\u6eb6\u5242\uff0c\u5728\u5ba4\u6e29\u4e0b\u8d85\u58f0\u63d0\u53d630\u5206\u949f\u3002\u7b2c\u56db\uff0c\u9009\u62e9\u5408\u9002\u7684\u7c92\u5f84\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76\u3002\u6700\u540e\uff0c\u8fd8\u6d4b\u8bd5\u4e86\u63d0\u53d6\u6301\u7eed\u65f6\u95f4\uff0810 \u5206\u949f\u300120 \u5206\u949f\u300130 \u5206\u949f\u300140 \u5206\u949f\u300150 \u5206\u949f\u300160 \u5206\u949f\uff09\u3002<\/p>\n

\u57fa\u4e8e\u8fd9\u4e9b\u7ed3\u679c\uff0c\u9009\u62e9\u6bcf\u4e2a\u76f8\u5173\u53d8\u91cf\u7684\u4e09\u4e2a\u6c34\u5e73\uff08\u4e0b\u3001\u4e2d\u3001\u4e0a\uff09\u8fdb\u884c\u4e2d\u5fc3\u7ec4\u5408\u8bbe\u8ba1\uff08CCD\uff09\u6765\u5206\u6790\u54cd\u5e94\u6a21\u5f0f\u5e76\u5efa\u7acb\u6a21\u578b\u3002<\/p>\n

 <\/p>\n<\/div>\n

\n

\u7edf\u8ba1\u5206\u6790<\/h3>\n

 <\/p>\n

\u4f7f\u7528RSM\u5bf9\u4eceCCD\u7a0b\u5e8f\u83b7\u5f97\u7684\u5b9e\u9a8c\u6570\u636e\u8fdb\u884c\u5206\u6790\uff0c\u4ee5\u62df\u5408\u4ee5\u4e0b\u4e8c\u9636\u591a\u9879\u5f0f\u6a21\u578b\uff08\u5f0f\uff081\uff09\uff09\u5e76\u83b7\u5f97\u56de\u5f52\u7cfb\u6570\u3002<\/p>\n

\"An<\/p>\n

\u5176\u4e2dX1<\/sub>\uff0c X2<\/sub>\uff0c\u2026\uff0c Xk<\/sub>\u00a0\u662f\u5f71\u54cd\u54cd\u5e94 Y \u7684\u7f16\u7801\u81ea\u53d8\u91cf\uff1b \u03b20<\/sub>, \u03b2\u6211<\/sub>\u00a0(i = 1, 2, \u2026, k), \u03b2\u4e8c\u3001<\/sub>\u00a0(i = 1, 2,\u2026,k) \u548c \u03b2ij<\/sub>\u00a0(i = 1, 2,\u2026, k) \u5206\u522b\u662f\u622a\u8ddd\u9879\u3001\u7ebf\u6027\u9879\u3001\u4e8c\u6b21\u9879\u548c\u4ea4\u4e92\u9879\u7684\u56de\u5f52\u7cfb\u6570\uff1b k \u662f\u53d8\u91cf\u7684\u6570\u91cf\u3002<\/p>\n

\u4f7f\u7528 Design Expert 8.0.5b \u7248\uff08STAT-EASE Inc.\uff09\u8f6f\u4ef6\u5bf9\u5b9e\u9a8c\u6570\u636e\u8fdb\u884c\u56de\u5f52\u548c\u56fe\u5f62\u5206\u6790\u3002\u4f7f\u7528\u51b3\u5b9a\u7cfb\u6570\u8bc4\u4f30\u6a21\u578b\u7684\u9002\u5e94\u6027\u8d28\u91cf\uff08\u53f3<\/em>2<\/sup>\uff09\u548c\u65b9\u5dee\u5206\u6790\uff08ANOVA\uff09\u3002\u4f7f\u7528\u62df\u5408\u7684\u4e8c\u6b21\u591a\u9879\u5f0f\u65b9\u7a0b\u7ed8\u5236\u54cd\u5e94\u66f2\u9762\u548c\u7b49\u9ad8\u7ebf\u56fe\u3002<\/p>\n

 <\/p>\n<\/div>\n<\/div>\n

\n
\u53bb\uff1a<\/a><\/div>\n

\u7ed3\u679c\u4e0e\u8ba8\u8bba<\/h2>\n

 <\/p>\n

\n

HPLC \u6216 UV-Vis \u7684\u7cfb\u7edf\u7cbe\u5ea6\u3001\u7ebf\u6027\u5ea6<\/h3>\n

 <\/p>\n

\u69f2\u76ae\u82f7\u548cTF\u88ab\u6307\u5b9a\u4e3a\u8bc4\u4ef7\u63d0\u53d6\u6548\u7387\u7684\u6807\u8bb0\u7269\u3002\u53c2\u8003\u6807\u51c6\u54c1\u548c\u5934\u72b6\u84fc\u63d0\u53d6\u7269\u7684 HPLC \u8c31\u663e\u793a\u5728\u00a0\u56fe1<\/a>\u3002\u5cf0\u9762\u79ef\u4e0e\u69f2\u76ae\u82f7\u6c34\u5e73\u7684\u6821\u51c6\u66f2\u7ebf\u4e3a\u00a0y<\/em>\u00a0= 47.622\u00a0X<\/em>\u00a0\u2212 0.2231\uff0c\u7ebf\u6027\u8303\u56f4\u4e3a 0.033-1.06 \u00b5g\uff08\u53f3<\/em>2<\/sup>\u00a0= 1.0000,\u00a0y<\/em>\u00a0= \u5cf0\u9762\u79ef\u548c\u00a0X<\/em>\u00a0= \u69f2\u76ae\u7519\u91cf\uff09\u3002\u5438\u5149\u5ea6\u4e0e TF \u91cf\u7684\u6821\u51c6\u66f2\u7ebf\u4e3a\u00a0y<\/em>\u00a0= 0.0029\u00a0X<\/em>\u00a0\u2013 0.0088\uff0c\u7ebf\u6027\u8303\u56f4\u4e3a 74.32-267.12 \u03bcg\uff08\u53f3<\/em>2<\/sup>\u00a0= 0.9996,\u00a0y<\/em>\u00a0= \u5438\u5149\u5ea6\u548c\u00a0X<\/em>\u00a0= TF \u91d1\u989d\uff09\u3002<\/p>\n

\n
\"An<\/div>\n
\n
\u56fe1<\/a><\/div>\n
\n

\u69f2\u76ae\u82f7\u5bf9\u7167\u54c1(a)\u548c\u5934\u82b1\u63d0\u53d6\u7269(b)\u5728260nm\u5904\u7684HPLC\u56fe\u8c31<\/p>\n

 <\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\n

\u53c2\u6570\u7684\u786e\u5b9a\u548c\u6c34\u5e73\u7684\u9009\u62e9<\/h3>\n
\n

 <\/p>\n

\u63d0\u53d6\u65b9\u6cd5\u7684\u6548\u679c<\/h4>\n

 <\/p>\n

\u6d4b\u8bd5\u4e86\u4e09\u79cd\u4e0d\u540c\u7684\u63d0\u53d6\u65b9\u6cd5\uff0c\u5305\u62ec\u6d78\u6e0d\u3001\u56de\u6d41\u548c\u8d85\u58f0\u63d0\u53d6\uff0c\u53c2\u6570\u503c\u5982\u4e0b\uff1a\u7c92\u5f84\uff0c10\u76ee\uff1b\u6eb6\u5242\u4e0e\u7269\u6599\u7684\u6bd4\u4f8b\uff0c10:1\uff08ml\/g\uff09\uff1b\u63d0\u53d6\u65f6\u95f4\uff0c\u56de\u6d41\u8d85\u58f0\u63d0\u53d630\u5206\u949f\uff0c\u6d78\u6e0d\u63d0\u53d612\u5c0f\u65f6\uff1b\u6eb6\u5242\u6210\u5206\uff0c70%\u4e59\u9187\u6c34\u6eb6\u6db2\uff1b\u6e29\u5ea6\uff0c\u5ba4\u6e29\u3002\u6bcf\u514b DM \u4e2d\u63d0\u53d6\u7684\u69f2\u76ae\u82f7\u548c TF \u7684\u91cf\u89c1\u4e0b\u8868\uff1a\u00a0\u56fe2<\/a>\u3002\u5b9e\u9a8c\u7ed3\u679c\u7684\u65b9\u5dee\u5206\u6790\u663e\u793a\u8fd9\u4e09\u79cd\u63d0\u53d6\u65b9\u6cd5\u4e4b\u95f4\u5b58\u5728\u663e\u7740\u5dee\u5f02\uff08\u78f7<\/em>\u00a0< 0.01\uff09\u3002\u540c\u65f6\uff0c\u8d85\u58f0\u63d0\u53d6\u65b9\u6cd5\u5f97\u5230\u7684\u69f2\u76ae\u82f7\u548cTF\u7684\u5f97\u7387\u6700\u9ad8\uff0c\u56e0\u6b64\u9009\u62e9\u5b83\u4f5c\u4e3a\u6211\u4eec\u7684\u63d0\u53d6\u65b9\u6cd5\u3002<\/p>\n

\n
\"An<\/div>\n
\n
\u56fe2<\/a><\/div>\n
\n

\u4e0d\u540c\u65b9\u6cd5\u4ece\u5934\u82b1\u4e2d\u63d0\u53d6\u69f2\u76ae\u7d20\uff08\u5de6\uff09\u548cTF\uff08\u53f3\uff09\u7684\u6548\u679c<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\n

 <\/p>\n

\u8403\u53d6\u6eb6\u5242\u7684\u5f71\u54cd<\/h4>\n

 <\/p>\n

\u6eb6\u5242\u662f\u5f71\u54cd\u5206\u6790\u7269\u56de\u6536\u7387\u7684\u5173\u952e\u56e0\u7d20\u3002\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u6d4b\u8bd5\u4e86\u6c34\u3001\u4e0d\u540c\u6d53\u5ea6\u7684\u7532\u9187\u548c\u4e0d\u540c\u6d53\u5ea6\u7684\u4e59\u9187\u3002\u5982\u56fe\u6240\u793a\u00a0\u56fe3<\/a>\uff0c60%\u4e59\u9187\u6c34\u6eb6\u6db2\u7684\u63d0\u53d6\u6548\u7387\u6700\u9ad8\u3002\u56e0\u6b64\uff0c\u9009\u62e950%\u300160%\u548c70%\u4e59\u9187\u4f5c\u4e3a\u4e0b\u3001\u4e2d\u3001\u4e0a\u5c42\u6eb6\u5242\u7ec4\u5408\u7269\uff0c\u8fdb\u884c\u8fdb\u4e00\u6b65\u7684RSM\u7814\u7a76\u3002<\/p>\n

\n
\"An<\/div>\n
\n
\u56fe3<\/a><\/div>\n
\n

\u6eb6\u5242\u7ec4\u6210\u5bf9\u8d85\u58f0\u6ce2\u8f85\u52a9\u63d0\u53d6\u5934\u9996\u8349\u69f2\u76ae\u82f7\u548cTF\u7684\u5f71\u54cd<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\n

 <\/p>\n

\u6eb6\u5242\u4e0e\u6750\u6599\u7684\u6bd4\u4f8b<\/h4>\n

 <\/p>\n

\u4f7f\u7528\u4e94\u4e2a\u503c\uff086:1\u30018:1\u300110:1\u300112:1\u300114:1\uff1b\u00a0\u4f53\u79ef\/\u7c73<\/em>\uff09\u3002\u6839\u636e\u89c4\u5219\u9009\u62e9\u5408\u9002\u7684\u6eb6\u5242\u6750\u6599\u6bd4\u503c[29<\/a>] \u8be5\u503c\u65e2\u4e0d\u80fd\u592a\u5c0f\uff08\u751f\u7269\u6d3b\u6027\u6210\u5206\u4e0d\u80fd\u5b8c\u5168\u63d0\u53d6\u51fa\u6765\uff09\uff0c\u4e5f\u4e0d\u80fd\u592a\u9ad8\uff08\u52a0\u5de5\u6210\u672c\u96be\u4ee5\u627f\u53d7\uff09\u3002\u5982\u4e2d\u6240\u4ecb\u7ecd\u7684\u00a0\u56fe4<\/a>\uff0c\u89c2\u5bdf\u5230\u69f2\u76ae\u82f7\u548cTF\u4ea7\u91cf\u5448\u589e\u52a0\u8d8b\u52bf\uff0c\u5f53\u6bd4\u4f8b\u7ea6\u4e3a10:1\u65f6\u8fbe\u5230\u6700\u9ad8\u503c\u3002\u53ef\u80fd\u7684\u89e3\u91ca\u662f\uff0c\u6eb6\u5242-\u6750\u6599\u6bd4\u4f8b\u7684\u589e\u52a0\u53ef\u80fd\u4f1a\u589e\u52a0\u6eb6\u5242\u8fdb\u5165\u7ec6\u80de\u7684\u6269\u6563\u6027\uff0c\u5e76\u589e\u5f3a\u915a\u7c7b\u5316\u5408\u7269\u4ece\u7ec6\u80de\u4e2d\u7684\u89e3\u5438\u300230<\/a>] \u5728\u672c\u7814\u7a76\u4e2d\uff0c\u5f53\u6bd4\u4f8b\u503c\u9ad8\u4e8e10:1\u65f6\uff0c\u69f2\u76ae\u7d20\u548cTF\u7684\u4ea7\u7387\u7565\u6709\u4e0b\u964d\uff0c\u8fd9\u53ef\u80fd\u662f\u7531\u4e8e\u4ea7\u54c1\u6536\u96c6\u6216\u5de5\u827a\u64cd\u4f5c\u4e2d\u7684\u635f\u5931\u8f83\u5927\u3002\u56e0\u6b64\uff0c\u540e\u7eed\u7814\u7a76\u4e2d\u5c06\u6eb6\u5242\u4e0e\u7269\u6599\u7684\u6bd4\u4f8b\u8bbe\u5b9a\u4e3a10\uff1a1\u4f5c\u4e3aRSM\u7684\u4e2d\u95f4\u6c34\u5e73\u3002<\/p>\n

\n
\"An<\/div>\n
\n
\u56fe4<\/a><\/div>\n
\n

\u6599\u6599\u6bd4\u5bf9\u69f2\u76ae\u82f7\u548cTF\u6536\u7387\u7684\u5f71\u54cd<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\n

 <\/p>\n

\u7c92\u5f84\u7684\u5f71\u54cd<\/h4>\n

 <\/p>\n

\u7c92\u5ea6\u662f\u53e6\u4e00\u4e2a\u9700\u8981\u8003\u8651\u7684\u91cd\u8981\u53d8\u91cf\u3002\u4e00\u822c\u6765\u8bf4\uff0c\u8403\u53d6\u6548\u7387\u968f\u7740\u7c92\u5f84\u7684\u51cf\u5c0f\u800c\u589e\u52a0[\u56fe5<\/a>]\u3002\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u7c92\u5f84\u8bbe\u5b9a\u4e3a\u76f4\u5f840.45-0.9\u6beb\u7c73\u3002<\/p>\n

\n
\"An<\/div>\n
\n
\u56fe5<\/a><\/div>\n
\n

\u7c92\u5f84\u5bf9\u69f2\u76ae\u82f7\u548cTF\u5f97\u7387\u7684\u5f71\u54cd<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\n

 <\/p>\n

\u63d0\u53d6\u65f6\u95f4\u7684\u5f71\u54cd<\/h4>\n

 <\/p>\n

\u9009\u62e9\u5408\u9002\u7684\u63d0\u53d6\u65f6\u95f4\u662f\u6211\u4eec\u521d\u6b65\u7814\u7a76\u7684\u6700\u540e\u4e00\u6b65\u3002\u6d4b\u8bd5\u4e86 10\u300120\u300130\u300140\u300150 \u548c 60 \u5206\u949f\u7684\u4e0d\u540c\u63d0\u53d6\u957f\u5ea6\u4ee5\u68c0\u67e5\u6700\u4f73\u503c\u3002\u7ed3\u679c\u8868\u660e\uff0c\u968f\u7740\u63d0\u53d6\u65f6\u95f4\u4ece10 min\u5ef6\u957f\u81f350 min\uff0c\u69f2\u76ae\u82f7\u548cTF\u7684\u5f97\u7387\u589e\u52a0\u3002\u56fe6<\/a>]\u3002\u572850 min\u6c34\u5e73\u65f6\uff0c\u69f2\u76ae\u82f7\u548cTF\u7684\u4ea7\u91cf\u8fbe\u5230\u6700\u9ad8\u91cf\u3002\u56e0\u6b64\uff0c\u9009\u53d640\u300150\u548c60 min\u4f5c\u4e3a\u63d0\u53d6\u65f6\u95f4\u7684\u4e0b\u3001\u4e2d\u3001\u4e0a\u6c34\u5e73\u3002<\/p>\n

\n
\"An<\/div>\n
\n
\u56fe6<\/a><\/div>\n
\n

\u63d0\u53d6\u65f6\u95f4\u5bf9\u69f2\u76ae\u82f7\u548cTF\u5f97\u7387\u7684\u5f71\u54cd<\/p>\n

 <\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\n

\u901a\u8fc7 RSM \u4f18\u5316\u8403\u53d6\u53c2\u6570<\/h3>\n
\n

 <\/p>\n

\u591a\u5143\u7ebf\u6027\u56de\u5f52\u7ed3\u679c\u53ca\u62df\u5408\u6a21\u578b\u7684\u5145\u5206\u6027\u5206\u6790<\/h4>\n

 <\/p>\n

\u91c7\u7528\u7531 20 \u6b21\u5b9e\u9a8c\u8fd0\u884c\u7ec4\u6210\u7684\u4e09\u56e0\u7d20\u4e09\u7ea7\u53ef\u65cb\u8f6c CCD\uff0c\u5728\u4e2d\u5fc3\u70b9\u8fdb\u884c 6 \u6b21\u91cd\u590d\u3002\u901a\u8fc7\u968f\u673a\u5316\u5b9e\u9a8c\u987a\u5e8f\uff0c\u53ef\u4ee5\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u65e0\u6cd5\u89e3\u91ca\u7684\u53d8\u5f02\u6027\u7684\u5f71\u54cd\u3002\u81ea\u53d8\u91cf\u662f\u6eb6\u5242\u6210\u5206 (X1<\/sub>, %,\u00a0\u4f53\u79ef\/\u4f53\u79ef<\/em>\uff0c\u4e59\u9187\/\u6c34\uff09\uff0c\u6eb6\u5242\u6750\u6599\u6bd4\uff08X2<\/sub>, ml\/g) \u548c\u8403\u53d6\u65f6\u95f4 (X3<\/sub>\uff0cmin\uff09\uff0c\u4ee5\u69f2\u76ae\u7d20\u548c TF \u4ea7\u91cf\u4e3a\u6307\u6807\u3002\u9009\u62e9\u56fa\u5b9a\u7684\u9897\u7c92\u5c3a\u5bf8\uff080.45-0.9 mm\uff09\u3002\u6240\u6709\u8fd0\u884c\u7684\u69f2\u76ae\u82f7\u548c TF \u4ea7\u91cf\u663e\u793a\u5728\u00a0\u8868\u683c1<\/a>\u3002\u57fa\u4e8e\u8fd9\u4e9b\u7ed3\u679c\uff0c\u4f7f\u7528\u4e8c\u9636\u591a\u9879\u5f0f\u6a21\u578b\uff08\u65b9\u7a0b\uff081\uff09\uff09\u8fdb\u884c\u591a\u5143\u7ebf\u6027\u56de\u5f52\u3002<\/p>\n

 <\/p>\n

\n

\u8868\u683c1<\/h3>\n
\n

\u53ef\u65cb\u8f6c\u4e2d\u5fc3\u590d\u5408\u8bbe\u8ba1\u8bbe\u7f6e\uff0c\u4ee5\u81ea\u53d8\u91cf\u7684\u539f\u59cb\u548c\u7f16\u7801\u5f62\u5f0f\uff08X1<\/sub>\uff0c X2<\/sub>\uff0c X3<\/sub>\uff09\u4ee5\u53ca\u54cd\u5e94\u53d8\u91cf\u69f2\u76ae\u82f7\u548c TF \u7684\u5b9e\u9a8c\u7ed3\u679c<\/p>\n<\/div>\n

\"An<\/div>\n<\/div>\n

\u81ea\u53d8\u91cf\u7684\u65b9\u5dee\u5206\u6790\u663e\u793a\u5728\u00a0\u88682<\/a>\u00a0\u8868\u660e\u6240\u6709\u8fd9\u4e09\u4e2a\u81ea\u53d8\u91cf\u90fd\u663e\u7740\u5f71\u54cd\u63d0\u53d6\u6548\u7387\uff08\u78f7<\/em>\u00a0< 0.05\uff09\u3002\u62df\u5408\u4e8c\u6b21\u6a21\u578b\u7684\u56de\u5f52\u53c2\u6570\u53ca\u5176\u5bf9\u5e94\u7684\u591a\u6b21\u6d4b\u5b9a\u7cfb\u6570\uff08\u53f3<\/em>2<\/sup>\uff09\u663e\u793a\u5728\u00a0\u88683<\/a>\u3002\u5b9e\u73b0\u4e86\u826f\u597d\u7684\u62df\u5408\uff0c\u5e76\u4e14\u6a21\u578b\u89e3\u91ca\u4e86\u54cd\u5e94\u7684\u53ef\u53d8\u6027\u3002\u9ad8\u00a0\u53f3<\/em>2<\/sup>\u00a0\u69f2\u76ae\u82f7\u548c TF \u7684\u503c\u5206\u522b\u4e3a 0.94 \u548c 0.96\uff0c\u8fd9\u610f\u5473\u7740\u5b9e\u9a8c\u6570\u636e\u8bc1\u5b9e\u4e86\u4e0e\u6a21\u578b\u9884\u6d4b\u7684\u6570\u636e\u7684\u517c\u5bb9\u6027\u3002\u53d8\u5f02\u7cfb\u6570\u7684\u8f83\u4f4e\u503c\uff08\u69f2\u76ae\u82f7\u4e3a 1.92%\uff0cTF \u4e3a 3.28%\uff09\u8868\u660e\u4ece\u62df\u5408\u6a21\u578b\u83b7\u5f97\u7684\u7ed3\u679c\u662f\u53ef\u9760\u7684\u3002\u8c03\u6574\u540e\u7684\u51b3\u5b9a\u7cfb\u6570\uff08\u53f3<\/em>2<\/sup>\u00a0Adj.) value \u91cd\u5efa\u5305\u542b\u6240\u6709*\u91cd\u8981\u672f\u8bed\u548c\u9ad8\u503c\u7684\u8868\u8fbe\u5f0f\u00a0\u53f3<\/em>2<\/sup>\u00a0\u8c03\u6574\u3002 \uff08\u53f3<\/em>2<\/sup>\u00a0\u8c03\u6574\u3002\u5206\u522b\u7b49\u4e8e87%\u300192%\uff09\u652f\u6301\u4e86\u8be5\u6a21\u578b\u7684\u91cd\u8981\u6027\u3002<\/p>\n

 <\/p>\n

\n

\u88682<\/h3>\n
\n

\u54cd\u5e94\u9762\u4e8c\u6b21\u6a21\u578b\u7684\u65b9\u5dee\u5206\u6790<\/p>\n<\/div>\n

\"An<\/div>\n
<\/div>\n<\/div>\n
\n

<\/h3>\n

\u88683<\/h3>\n
\n

\u54cd\u5e94\u53d8\u91cf\u69f2\u76ae\u7d20\u548c TF \u7684\u9884\u6d4b\u4e8c\u9636\u6a21\u578b\u7684\u56de\u5f52\u7cfb\u6570<\/p>\n<\/div>\n

\"An<\/div>\n<\/div>\n

\u5931\u62df\u68c0\u9a8c\u7528\u4e8e\u9a8c\u8bc1\u6a21\u578b\u9002\u5408\u5ea6\u7684\u5145\u5206\u6027\u3002\u5931\u62df\u68c0\u9a8c\u7684\u65b9\u5dee\u5206\u6790\u5bf9\u4e8e\u69f2\u76ae\u82f7\u548c TF \u4ea7\u91cf\u5e76\u4e0d\u663e\u7740\uff08\u78f7<\/em>\u00a0> 0.05)\uff0c\u8868\u660e\u6a21\u578b\u80fd\u591f\u5145\u5206\u62df\u5408\u5b9e\u9a8c\u6570\u636e[\u88684<\/a>].<\/p>\n

 <\/p>\n

\n

\u88684<\/h3>\n
\n

\u69f2\u76ae\u82f7\u548c TF \u5931\u62df\u68c0\u9a8c\u7684\u65b9\u5dee\u5206\u6790<\/p>\n<\/div>\n

\"An<\/div>\n<\/div>\n<\/div>\n
\n

 <\/p>\n

\u54cd\u5e94\u9762\u5206\u6790<\/h4>\n

 <\/p>\n

\u81ea\u4ece;\u6a21\u578b\u62df\u5408\u826f\u597d\uff0c\u56de\u5f52\u65b9\u7a0b\u5145\u5206\u89e3\u91ca\u4e86\u54cd\u5e94\u503c\u3002\u7ed8\u5236\u54cd\u5e94\u66f2\u9762\u66f2\u7ebf\u4ee5\u5c55\u793a\u81ea\u53d8\u91cf\u7684\u76f8\u4e92\u4f5c\u7528\u5e76\u786e\u5b9a\u6bcf\u4e2a\u81ea\u53d8\u91cf\u7684\u6700\u5927\u54cd\u5e94\u7684\u6700\u4f73\u503c\u3002\u81ea\u53d8\u91cf\u548c\u56e0\u53d8\u91cf\u4e4b\u95f4\u7684\u5173\u7cfb\u901a\u8fc7\u4e09\u7ef4 (3D) \u54cd\u5e94\u66f2\u9762\u56fe\u548c\u4e8c\u7ef4 (2D) \u7b49\u503c\u7ebf\u56fe\u8fdb\u884c\u8bf4\u660e\u3002 3D \u54cd\u5e94\u9762\u548c 2D \u7b49\u503c\u7ebf\u56fe\u4ee5\u56de\u5f52\u65b9\u7a0b\u7684\u56fe\u5f62\u8868\u793a\u5f62\u5f0f\u63d0\u4f9b [\u56fe\u00a0\u200b[\u56fe7<\/span>7<\/a>\u00a0\u548c\u00a0\u200b\u548c8]\u3002<\/span>8<\/a>]\u3002\u6bcf\u6761\u8f6e\u5ed3\u66f2\u7ebf\u4ee3\u8868\u4e24\u4e2a\u81ea\u53d8\u91cf\u7684\u65e0\u9650\u591a\u4e2a\u7ec4\u5408\uff0c\u540c\u65f6\u5c06\u53e6\u4e00\u4e2a\u81ea\u53d8\u91cf\u4fdd\u6301\u5728\u9759\u6b62\u70b9\u3002\u901a\u8fc7\u8fd9\u79cd\u65b9\u5f0f\uff0c\u53ef\u4ee5\u8f7b\u677e\u5730\u53ef\u89c6\u5316 3D \u54cd\u5e94\u9762\u3002\u00a0\u56fe7a<\/a>\u00a0\u663e\u793a\u4e86\u7531\u6eb6\u5242\u6210\u5206\u548c\u6eb6\u5242\u6750\u6599\u6bd4\u6a21\u578b\u5f00\u53d1\u7684 3D \u54cd\u5e94\u9762\u51fd\u6570\u3002\u6eb6\u5242\u6210\u5206\u8868\u73b0\u51fa\u5bf9\u54cd\u5e94\u7684\u4e8c\u6b21\u5f71\u54cd\u3002\u5f53\u4f7f\u752865%\u4e59\u9187\u65f6\u69f2\u76ae\u82f7\u542b\u91cf\u8fbe\u5230\u6700\u9ad8\u503c\u3002\u7c7b\u4f3c\u5730\uff0c\u6eb6\u5242\u4e0e\u6750\u6599\u7684\u6bd4\u4f8b\u540c\u65f6\u8868\u73b0\u51fa\u5bf9\u69f2\u76ae\u82f7\u7684\u4e8c\u6b21\u6548\u5e94\u3002\u6eb6\u5242\u7ec4\u6210\u548c\u6eb6\u5242\u6750\u6599\u6bd4\u5bf9TF\u7684\u5f71\u54cd\u7ed3\u679c\u663e\u793a\u5728\u00a0\u56fe8a<\/a>\u3002\u6eb6\u5242\u7ec4\u6210\u5bf9 60% \u548c 70% \u4e59\u9187\u4e4b\u95f4\u7684\u6700\u5927\u54cd\u5e94\u663e\u793a\u51fa\u4e8c\u6b21\u6548\u5e94\u3002\u7c7b\u4f3c\u5730\uff0c\u5f53\u6eb6\u5242\u7ec4\u6210\u4e00\u5b9a\u65f6\uff0c\u968f\u7740\u6eb6\u5242\u4e0e\u7269\u6599\u6bd4\u7684\u589e\u52a0\uff0cTF\u9010\u6e10\u589e\u52a0\uff0c\u5e76\u5728\u6eb6\u5242\u4e0e\u7269\u6599\u6bd4\u7ea6\u4e3a10:1\u65f6\u8fbe\u5230\u6700\u9ad8\u503c\u3002<\/p>\n

\n
\"An<\/div>\n
\n
\u56fe7<\/a><\/div>\n
\n

\u54cd\u5e94\u66f2\u9762\u56fe\uff08a\u3001c \u548c e\uff09\u548c\u7b49\u9ad8\u7ebf\u56fe\uff08b\u3001d \u548c f\uff09\u663e\u793a\u6eb6\u5242\u7ec4\u6210 (X1)\u3001\u6eb6\u5242\u6750\u6599\u6bd4\u4f8b (X2) \u548c\u8403\u53d6\u65f6\u95f4 (X3) \u5bf9\u69f2\u76ae\u82f7\u4ea7\u7387\u7684\u5f71\u54cd<\/p>\n<\/div>\n<\/div>\n<\/div>\n

\n
\"An<\/div>\n
\n
\u56fe8<\/a><\/div>\n
<\/div>\n
\n

\u54cd\u5e94\u66f2\u9762\u56fe\uff08a\u3001c \u548c e\uff09\u548c\u7b49\u9ad8\u7ebf\u56fe\uff08b\u3001d \u548c f\uff09\u663e\u793a\u6eb6\u5242\u7ec4\u6210 (X1)\u3001\u6eb6\u5242\u6750\u6599\u6bd4\u4f8b (X2) \u548c\u8403\u53d6\u65f6\u95f4 (X3) \u5bf9 TF \u4ea7\u7387\u7684\u5f71\u54cd<\/p>\n<\/div>\n<\/div>\n<\/div>\n

\u81ea\u53d8\u91cf\u6eb6\u5242\u7ec4\u6210\u548c\u63d0\u53d6\u65f6\u95f4\u5bf9\u69f2\u76ae\u82f7\u548c TF \u4ea7\u91cf\u54cd\u5e94\u503c\u7684\u5f71\u54cd\u5982\u56fe\u6240\u793a\u00a0\u200b\u56fe7c\uff0c<\/span>7c<\/a>,\u00a0\u200b,7d,<\/span>7\u5929<\/a>,\u00a0\u200b,8c,<\/span>8c<\/a>,\u00a0\u200b,8\u5929,<\/span>8\u5929<\/a>\uff0c \u5206\u522b\u3002\u901a\u8fc7\u68c0\u67e5\u4fdd\u6301\u53e6\u4e00\u4e2a\u81ea\u53d8\u91cf\u6eb6\u5242\u6750\u6599\u6bd4\u5728\u56fa\u5b9a\u70b9\u6052\u5b9a\u800c\u751f\u6210\u7684\u7b49\u503c\u7ebf\u56fe\uff0c\u53ef\u4ee5\u8f7b\u677e\u7406\u89e3\u4e24\u4e2a\u81ea\u53d8\u91cf\u4e4b\u95f4\u7684\u4ea4\u4e92\u5173\u7cfb[\u56fe\u00a0\u200b[\u56fe7d<\/span>7\u5929<\/a>\u00a0\u548c\u00a0\u200b\u548c8d]\u3002<\/span>8\u5929<\/a>]\u3002\u968f\u7740\u6eb6\u5242\u7ec4\u6210\u548c\u63d0\u53d6\u65f6\u95f4\u7684\u589e\u52a0\uff0c\u69f2\u76ae\u82f7\u548cTF\u7684\u4ea7\u7387\u663e\u7740\u589e\u52a0\u3002\u7136\u800c\uff0c\u5f53\u81ea\u53d8\u91cf\u8d85\u8fc7\u4e00\u5b9a\u503c\u65f6\uff0c\u69f2\u76ae\u82f7\u548c TF \u4ea7\u91cf\u4e0d\u518d\u589e\u52a0\u3002\u6eb6\u5242\u7ec4\u6210\u548c\u63d0\u53d6\u65f6\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u5bf9\u69f2\u76ae\u82f7\u4ea7\u91cf\u7684\u5f71\u54cd\u5e76\u4e0d\u5177\u6709\u7edf\u8ba1\u663e\u7740\u6027\uff0c\u4f46\u5177\u6709\u663e\u7740\u6027\uff08\u78f7<\/em>\u00a0< 0.01) \u5bf9 TF \u63d0\u53d6\u7684\u5f71\u54cd\u3002<\/p>\n

\u4eba\u7269\u00a0\u200b\u56fe7e<\/span>7e<\/a>\u00a0\u548c\u00a0\u200b\u548c8e<\/span>8e<\/a>\u00a0\u8bc1\u660e\u4e86\u6eb6\u5242-\u6750\u6599\u6bd4\u548c\u63d0\u53d6\u65f6\u95f4\u5bf9\u69f2\u76ae\u82f7\u548c TF \u4ea7\u7387\u7684\u5f71\u54cd\u3002\u968f\u7740\u63d0\u53d6\u65f6\u95f4\u548c\u6eb6\u5242-\u6750\u6599\u6bd4\u7684\u589e\u52a0\uff0c\u69f2\u76ae\u82f7\u548c TF \u7684\u5f97\u7387\u589e\u52a0\uff0c\u8fd9\u8868\u660e\u69f2\u76ae\u82f7\u548c TF \u7684\u63d0\u53d6\u7387\u4e0e\u63d0\u53d6\u65f6\u95f4\u548c\u6eb6\u5242-\u6750\u6599\u6bd4\u6210\u6b63\u6bd4\u3002\u4ece\u5934\u82b1\u4e2d\u63d0\u53d6\u69f2\u76ae\u82f7\u548c TF \u7684\u4e24\u4e2a\u81ea\u53d8\u91cf\u7684\u4ea4\u4e92\u4f5c\u7528\u4e0d\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u3002<\/p>\n

 <\/p>\n<\/div>\n<\/div>\n

\n

\u9a8c\u8bc1\u5b9e\u9a8c<\/h3>\n

 <\/p>\n

\u4e3a\u4e86\u9a8c\u8bc1\u6a21\u578b\u7684\u9884\u6d4b\u80fd\u529b\uff0c\u5728RSM\u5cad\u5206\u6790\u5f97\u51fa\u7684\u4f18\u5316\u6761\u4ef6\u4e0b\u6d4b\u8bd5\u4e86\u6700\u4f73\u54cd\u5e94\u53d8\u91cf\u3002\u56e0\u6b64\uff0c\u89c2\u6d4b\u503c\u53ef\u4ee5\u5728\u6a21\u578b\u9884\u6d4b\u503c\u7684 95% \u7f6e\u4fe1\u533a\u95f4\u5185\u4ee4\u4eba\u6ee1\u610f\u5730\u5b9e\u73b0 [\u88685<\/a>].<\/p>\n

 <\/p>\n

\n

\u88685<\/h3>\n
\n

\u54cd\u5e94\u53d8\u91cf\u69f2\u76ae\u7d20\u548c TF \u7684\u9884\u6d4b\u503c\u548c\u89c2\u6d4b\u503c\u4e4b\u95f4\u7684\u6bd4\u8f83<\/p>\n<\/div>\n

\"An<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\u53bb\uff1a<\/a><\/div>\n

\u7ed3\u8bba<\/h2>\n

 <\/p>\n

\u91c7\u7528\u4e00\u6b21\u4e00\u56e0\u7d20\u6cd5\u7ed3\u5408CCD\uff0c\u5bf9\u8d85\u58f0\u8f85\u52a9\u63d0\u53d6\u53c2\u6570\uff08\u5305\u62ec\u6eb6\u5242\u7ec4\u6210\u3001\u6eb6\u5242\u4e0e\u7269\u6599\u6bd4\u548c\u63d0\u53d6\u65f6\u95f4\uff09\u8fdb\u884c\u4e86\u4f18\u5316\uff0c\u4ee5\u63d0\u53d6\u9996\u4e4c\u4e2d\u69f2\u76ae\u82f7\u548cTF\u3002\u7ed3\u679c\u8868\u660e\u4e8c\u9636\u591a\u9879\u5f0f\u6a21\u578b\u5bf9\u63d0\u53d6\u6570\u636e\u7ed9\u51fa\u4e86\u4ee4\u4eba\u6ee1\u610f\u7684\u63cf\u8ff0\u3002\u4f18\u5316\u6761\u4ef6\u4e3a\uff1a\u63d0\u53d6\u65b9\u6cd5\uff0c\u8d85\u58f0\u63d0\u53d6\uff1b\u6eb6\u5242\uff0c\u6700\u597d\u752865%\u4e59\u9187\u6c34\u6eb6\u6db2\u8fdb\u884c\u5706\u6574\uff1b\u7c92\u5f84\uff0c0.45-0.9\u6beb\u7c73\uff1b\u6eb6\u5242\u4e0e\u7269\u6599\u7684\u6bd4\u4f8b\uff0c\u820d\u5165\u81f310:1\uff1b\u63d0\u53d6\u65f6\u95f4\uff0c\u820d\u5165\u4e3a 54 \u5206\u949f\u3002\u8fd9\u9879\u7814\u7a76\u53ef\u4ee5\u4e3a\u4f55\u9996\u4e4c\u7684\u5de5\u4e1a\u63d0\u53d6\u8fc7\u7a0b\u63d0\u4f9b\u57fa\u7840\u4fe1\u606f\u548c\u6709\u4ef7\u503c\u7684\u89c1\u89e3\u3002<\/p>\n

 <\/p>\n<\/div>\n

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\u53bb\uff1a<\/a><\/div>\n

\u81f4\u8c22<\/h2>\n

 <\/p>\n

\n

\u4f5c\u8005\u8877\u5fc3\u611f\u8c22\u8d35\u5dde\u6c83\u66fc\u836f\u4e1a\u516c\u53f8\u63d0\u4f9b\u539f\u6599\u4ee5\u53ca\u8d35\u5dde\u7701\u91cd\u5927\u79d1\u6280\u4e13\u9879\uff082011 6019-02\uff09\u3001\u8d35\u5dde\u7701\u836f\u7269\u5206\u6790\u79d1\u6280\u521b\u65b0\u4eba\u624d\u56e2\u961f\u8ba1\u5212\uff082011 6019-02\uff09\u7684\u8d44\u52a9\u3002\u8d35\u5dde\u7701\u4e2d\u836f\u73b0\u4ee3\u5316\u79d1\u6280\u4ea7\u4e1a\u7814\u7a76\u4e0e\u53d1\u5c55\u4e13\u9879\uff08ZY 2011 3013\uff09\u3001\u4e2d\u836f\u56fd\u836f\u6807\u51c6\u5316\u7279\u8272\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u3001\u8d35\u5dde\u7701\u7279\u8272\u91cd\u70b9\u5b9e\u9a8c\u5ba4\uff082011 4008\uff09\u7701\u6559\u80b2\u5385\uff0e \uff08\u7f16\u53f7\uff1aKY 2012 005\uff09\u3002<\/p>\n

 <\/p>\n<\/div>\n<\/div>\n

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\u53bb\uff1a<\/a><\/div>\n

\u811a\u6ce8<\/h2>\n
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\n

\u652f\u6301\u6765\u6e90\uff1a<\/strong>\u00a0\u96f6<\/p>\n

\u5229\u76ca\u51b2\u7a81\uff1a<\/strong>\u00a0\u6ca1\u6709\u5ba3\u5e03\u3002<\/p>\n

 <\/p>\n<\/div>\n<\/div>\n

\n
\u53bb\uff1a<\/a><\/div>\n

\u53c2\u8003<\/h2>\n

 <\/p>\n

\n
1.\u00a0\u4efb\u521a, \u5e38\u5cf0, \u9646\u4e66, \u949f\u6d69, \u5f20\u521a. \u836f\u7406\u7814\u7a76\u00a0\u5934\u82b1\u84fc<\/em>\u00a0Buch-Ham.ex D. Don\u3002\u00a0\u4e2d\u56fd\u4e2d\u836f\u6742\u5fd7\u3002\u00a0<\/span>1995;2<\/span>\uff1a107-9\u3002 28.[\u8003\u7814<\/a>]\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
2.\u00a0\u674e\u660e\u5347\uff0c\u6881\u6ce2\uff0c\u5510\u5efa\u4f1f\uff0c\u8c22\u52c7\uff0c\u5de6\u7231\u5e73\uff0c\u675c\u950b\u3002\u70ed\u6dcb\u6e05\u9897\u7c92\u6cb9\u7ec6\u83cc\u6027\u80be\u76c2\u80be\u708e\u6a21\u578b\u5927\u9f20\u836f\u6548\u5b66\u7814\u7a76\u3002\u00a0\u4e2d\u56fd\u4e2d\u836f\u6742\u5fd7\u3002\u00a0<\/span>2006;2<\/span>\uff1a153\u20135\u3002 [\u8003\u7814<\/a>]\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
3.\u00a0\u7a0b\u6c38\u751f, \u738bJY, \u90ddJJ.\u6258\u7279\u7f57\u5b9a\u8054\u5408\u70ed\u6dcb\u6e05\u9897\u7c92\u6cbb\u7597\u8180\u80f1\u8fc7\u5ea6\u6d3b\u52a8\u75c7\u7684\u7597\u6548\u89c2\u5bdf\u00a0\u4e0b\u5df4\u7597\u6cd5\u4e34\u5e8a\u3002\u00a0<\/span>2012;4<\/span>\uff1a500\u20131\u3002\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
4.\u00a0Pereira MA\u3001Grubbs CJ\u3001Barnes LH\u3001Li H\u3001Olson GR\u3001Eto I \u7b49\u3002\u690d\u7269\u5316\u5b66\u7269\u8d28\u59dc\u9ec4\u7d20\u548c\u69f2\u76ae\u7d20\u5bf9\u6c27\u5316\u5076\u6c2e\u7532\u70f7\u8bf1\u5bfc\u7684\u7ed3\u80a0\u764c\u548c 7,12-\u4e8c\u7532\u57fa\u82ef\u5e76[a]\u84bd\u8bf1\u5bfc\u7684\u5927\u9f20\u4e73\u817a\u764c\u7684\u5f71\u54cd\u3002\u00a0\u81f4\u764c\u4f5c\u7528\u3002\u00a0<\/span>1996;6<\/span>\uff1a1305\u201311\u3002 [\u8003\u7814<\/a>]\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
5.\u00a0\u5361\u5c14\u5854\u5409\u9f99 S\u3001Ranelletti FO\u3001Rinelli A\u3001Maggiano N\u3001Colasante A\u3001Musiani P \u7b49\u3002\u4ed6\u83ab\u6614\u82ac\u548c\u69f2\u76ae\u7d20\u4e0e II \u578b\u96cc\u6fc0\u7d20\u7ed3\u5408\u4f4d\u70b9\u7684\u76f8\u4e92\u4f5c\u7528\u4ee5\u53ca\u4ed6\u83ab\u6614\u82ac\u548c\u69f2\u76ae\u7d20\u5728\u4eba\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2d\u7684\u6297\u589e\u6b96\u6d3b\u6027\u3002\u00a0Am J Respir Cell Mol Biol\u3002\u00a0<\/span>1997;1<\/span>\uff1a51-9\u3002 [\u8003\u7814<\/a>]\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
6.\u00a0Aviram M\uff0cFuhrman B\u3002\u591a\u915a\u7c7b\u9ec4\u916e\u6291\u5236\u5de8\u566c\u7ec6\u80de\u4ecb\u5bfc\u7684 LDL \u6c27\u5316\u5e76\u51cf\u5f31\u52a8\u8109\u7ca5\u6837\u786c\u5316\u5f62\u6210\u3002\u00a0\u52a8\u8109\u7ca5\u6837\u786c\u5316\u3002\u00a0<\/span>1998;137<\/span>\uff08\u8865\u5145\uff09\uff1aS45\u201350\u3002 [\u8003\u7814<\/a>]\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
7.\u00a0\u4e25\u6653\u9f99\uff0c\u674e\u957f\u6e05\uff0c\u5218\u6c38\u65b0\uff0c\u5e38\u6653\uff0c\u5eb7\u4f1f\u82f1\u3002\u5934\u82b1\u84fc\u7684\u6297\u6c27\u5316\u6d3b\u6027\u3002\u00a0\u94a6\u836f\u4e1a.\u00a0<\/span>2010;39<\/span>\uff1a3659\u201361\u3002\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
8.\u00a0Siess MH\u3001Leclerc J\u3001Canivenc-Lavier MC\u3001Rat P\u3001Suschetet M\u3002\u5929\u7136\u7c7b\u9ec4\u916e\u5bf9\u4eba\u548c\u5927\u9f20\u809d\u5fae\u7c92\u4f53\u5355\u52a0\u6c27\u9176\u6d3b\u6027\u7684\u5f02\u8d28\u6027\u5f71\u54cd\u3002\u00a0\u6bd2\u7406\u5b66\u5e94\u7528\u836f\u7406\u5b66\u3002\u00a0<\/span>1995;1<\/span>\uff1a73\u20138\u3002 [\u8003\u7814<\/a>]\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
9.\u00a0Agullo G\u3001Gamet-Payrastre L\u3001Manenti S\u3001Viala C\u3001R\u00e9m\u00e9sy C\u3001Chap H \u7b49\u3002\u7c7b\u9ec4\u916e\u7ed3\u6784\u4e0e\u78f7\u8102\u9170\u808c\u9187 3-\u6fc0\u9176\u6291\u5236\u4e4b\u95f4\u7684\u5173\u7cfb\uff1a\u4e0e\u916a\u6c28\u9178\u6fc0\u9176\u548c\u86cb\u767d\u6fc0\u9176 C \u6291\u5236\u7684\u6bd4\u8f83\u3002\u00a0\u751f\u7269\u5316\u5b66\u836f\u7406\u5b66\u3002\u00a0<\/span>1997;11<\/span>\uff1a1649\u201357\u3002 [\u8003\u7814<\/a>]\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
10.\u00a0Conseil G\u3001Baubichon-Cortay H\u3001Dayan G\u3001Jault JM\u3001Barron D\u3001Di Pietro A\u3002\u7c7b\u9ec4\u916e\uff1a\u4e00\u7c7b\u5728\u5c0f\u9f20 P-\u7cd6\u86cb\u767d\u4e0a\u7684\u90bb\u8fd1 ATP \u548c\u7c7b\u56fa\u9187\u7ed3\u5408\u4f4d\u70b9\u5177\u6709\u53cc\u529f\u80fd\u76f8\u4e92\u4f5c\u7528\u7684\u8c03\u8282\u5242\u3002\u00a0\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a A.\u00a0<\/span>1998;17<\/span>\uff1a9831\u20136\u3002\u00a0[PMC \u514d\u8d39\u6587\u7ae0<\/a>]<\/span>\u00a0[\u8003\u7814<\/a>]\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
11.\u00a0Hertog MG\u3001Kromhout D\u3001Aravanis C\u3001Blackburn H\u3001Buzina R\u3001Fidanza F \u7b49\u3002\u4e03\u4e2a\u56fd\u5bb6\u7814\u7a76\u4e2d\u7684\u7c7b\u9ec4\u916e\u6444\u5165\u91cf\u4e0e\u51a0\u5fc3\u75c5\u548c\u764c\u75c7\u7684\u957f\u671f\u98ce\u9669\u3002\u00a0\u62f1\u95e8\u5b9e\u4e60\u533b\u751f\u3002\u00a0<\/span>1995;4<\/span>\uff1a381\u20136\u3002 [\u8003\u7814<\/a>]\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
12.\u00a0Liyana-Pathirana C\uff0cShahidi F\u3002\u4f7f\u7528\u54cd\u5e94\u9762\u6cd5\u4f18\u5316\u5c0f\u9ea6\u4e2d\u915a\u7c7b\u5316\u5408\u7269\u7684\u63d0\u53d6\u3002\u00a0\u98df\u54c1\u5316\u5b66\u3002\u00a0<\/span>2005;1<\/span>\uff1a47\u201356\u3002\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
13.\u00a0Li WL\uff0cZheng HC\uff0cBukuru J\uff0cDe Kimpe N\u3002\u4f20\u7edf\u4e2d\u533b\u7cfb\u7edf\u4e2d\u7528\u4e8e\u6cbb\u7597\u7cd6\u5c3f\u75c5\u7684\u5929\u7136\u836f\u7269\u3002\u00a0J Ethnopharmacol\u3002\u00a0<\/span>2004;1<\/span>\uff1a1-21\u3002 [\u8003\u7814<\/a>]\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
14.\u00a0Normile D. \u4e9a\u6d32\u533b\u5b66\u3002\u4e2d\u533b\u65b0\u9762\u8c8c\u3002\u00a0\u79d1\u5b66\u3002\u00a0<\/span>2003;5604<\/span>\uff1a188\u201390\u3002 [\u8003\u7814<\/a>]\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
15.\u00a0DeFeudis FV\u3001Drieu K. \u94f6\u674f\u53f6\u63d0\u53d6\u7269 (EGb 761) \u548c CNS \u529f\u80fd\uff1a\u57fa\u7840\u7814\u7a76\u548c\u4e34\u5e8a\u5e94\u7528\u3002\u00a0\u5f53\u524d\u836f\u7269\u9776\u70b9\u3002\u00a0<\/span>2000;1<\/span>\uff1a25\u201358\u3002 [\u8003\u7814<\/a>]\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
16.\u00a0Rowland I. \u6700\u4f73\u8425\u517b\uff1a\u7ea4\u7ef4\u548c\u690d\u7269\u5316\u5b66\u7269\u8d28\u3002\u00a0Proc Nutr Soc\u3002\u00a0<\/span>1999;02<\/span>\uff1a415\u20139\u3002 [\u8003\u7814<\/a>]\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
17.\u00a0\u6768BB\uff0c\u51afR\uff0c\u738bWC\uff0c\u5f20\u4e3d\u4e91\uff0c\u53f6\u6653\u660e\uff0c\u738bY\uff0c\u7b49\u3002\u91c7\u7528 HPLC\/DAD\/MS \u5b9a\u91cf\u5206\u6790\u82d7\u65cf\u5730\u65b9\u8349\u836f\u5934\u82b1\u84fc\u4e2d\u7684 3 \u79cd\u6d3b\u6027\u6210\u5206\u3002\u00a0\u4e2d\u56fd\u836f\u7269\u5206\u6790\u6742\u5fd7\u3002\u00a0<\/span>2008;11<\/span>\uff1a1793\u20136\u3002\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
18.\u00a0\u5f90\u5efa\uff0c\u5f20\u6c38\u5e73\uff0c\u7a0b\u6dd1\u8d24\u3002\u5fae\u6ce2\u8f85\u52a9\u63d0\u53d6\u4e2d\u836f\u6750\u7684\u7814\u7a76\u00a0\u5934\u72b6\u84fc Buch.-Ham\u3002\u524d\u4efb<\/em>\u00a0D .\u00a0Don J Med Pharm Chin Minor\u3002\u00a0<\/span>2012;8<\/span>\uff1a76\u20137\u3002\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
19.\u00a0\u8d75\u65b0\u6210\uff0c\u767d\u534e\uff0c\u738b\u6c38\u751f\uff0c\u5218\u963fQ\uff0c\u674e\u56fd\u5e86\u3002\u5934\u82b1\u84fc\u603b\u9ec4\u916e\u7684\u63d0\u53d6\u5de5\u827a\u3002\u00a0\u674e\u65f6\u73cd\u533b\u5b66\u533b\u5b66\u7814\u7a76\u4e2d\u5fc3\u3002\u00a0<\/span>2009;11<\/span>\uff1a2815\u20136\u3002\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
20.\u00a0Silva EM\u3001Rogez H\u3001Larondelle Y\u3002\u4f7f\u7528\u54cd\u5e94\u9762\u6cd5\u4f18\u5316\u4ece Inga edulis \u53f6\u4e2d\u63d0\u53d6\u915a\u7c7b\u7269\u8d28\u3002\u00a0\u4e5d\u6708\u666e\u91cc\u592b\u6280\u672f\u3002\u00a0<\/span>2007;3<\/span>\uff1a381\u20137\u3002\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
21.\u00a0\u7530S\uff0c\u5468X\uff0c\u9f9a\u534e\uff0c\u9a6cX\uff0c\u5f20F\u3002\u65b0\u7586\u828d\u836f\u591a\u7cd6\u63d0\u53d6\u4f18\u5316\u7684\u6b63\u4ea4\u8bd5\u9a8c\u8bbe\u8ba1\u3002\u00a0Pharmacogn \u6742\u5fd7\u3002\u00a0<\/span>2011;25<\/span>\uff1a4-8\u3002\u00a0[PMC \u514d\u8d39\u6587\u7ae0<\/a>]<\/span>\u00a0[\u8003\u7814<\/a>]\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
22.\u00a0Arslan-Alaton I\u3001Tureli G\u3001Olmez-Hanci T\u3002\u4f7f\u7528\u7c7b Photo-Fenton \u9ad8\u7ea7\u6c27\u5316\u5de5\u827a\u5904\u7406\u5076\u6c2e\u67d3\u6599\u751f\u4ea7\u5e9f\u6c34\uff1a\u901a\u8fc7\u54cd\u5e94\u9762\u65b9\u6cd5\u8fdb\u884c\u4f18\u5316\u3002\u00a0J Photochem Photobiol A Chem\u3002\u00a0<\/span>2009;2-3<\/span>\uff1a142\u201353\u3002\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
23.\u00a0\u5510\u6653\uff0c\u989c\u4e3d\uff0c\u9ad8\u5065\uff0c\u845b\u534e\uff0c\u6768\u534e\uff0c\u6797\u5a1c\u3002 \u6839\u591a\u7cd6\u63d0\u53d6\u5de5\u827a\u4f18\u5316\u53ca\u6297\u6c27\u5316\u4f5c\u7528\u7814\u7a76\u00a0\u8865\u8840\u8349<\/em>\u00a0\u6606\u7b56\u3002\u00a0Pharmacogn \u6742\u5fd7\u3002\u00a0<\/span>2011;27<\/span>\uff1a186\u201392\u3002\u00a0[PMC \u514d\u8d39\u6587\u7ae0<\/a>]<\/span>\u00a0[\u8003\u7814<\/a>]\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
24.\u00a0Ba\u015f D\uff0c\u535a\u4e9a\u897f HIH\u3002\u5efa\u6a21\u548c\u4f18\u5316 I\uff1a\u54cd\u5e94\u9762\u65b9\u6cd5\u7684\u53ef\u7528\u6027\u3002\u00a0\u98df\u54c1\u5de5\u7a0b\u6742\u5fd7\u3002\u00a0<\/span>2007;3<\/span>\uff1a836\u201345\u3002\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
25.\u00a0Bahorun T\u3001Luximon-Ramma A\u3001Crozier A\u3001Aruoma OI\u3002\u6bdb\u91cc\u6c42\u65af\u852c\u83dc\u7684\u603b\u915a\u3001\u7c7b\u9ec4\u916e\u3001\u539f\u82b1\u9752\u7d20\u548c\u7ef4\u751f\u7d20 C \u6c34\u5e73\u4ee5\u53ca\u6297\u6c27\u5316\u6d3b\u6027\u3002\u00a0\u98df\u54c1\u519c\u4e1a\u6742\u5fd7\u3002\u00a0<\/span>2004;12<\/span>\uff1a1553\u201361\u3002\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
26.\u00a0\u6797JY\uff0c\u5510CY.\u6d4b\u5b9a\u6240\u9009\u6c34\u679c\u548c\u852c\u83dc\u4e2d\u7684\u603b\u915a\u548c\u7c7b\u9ec4\u916e\u542b\u91cf\uff0c\u53ca\u5176\u5bf9\u5c0f\u9f20\u813e\u7ec6\u80de\u589e\u6b96\u7684\u523a\u6fc0\u4f5c\u7528\u3002\u00a0\u98df\u54c1\u5316\u5b66\u3002\u00a0<\/span>2007;1<\/span>\uff1a140\u20137\u3002\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
27.\u00a0Meda A\u3001Lamien CE\u3001Romito M\u3001Millogo J\u3001Nacoulma OG\u3002\u5e03\u57fa\u7eb3\u6cd5\u6851\u8702\u871c\u4e2d\u603b\u915a\u3001\u7c7b\u9ec4\u916e\u548c\u812f\u6c28\u9178\u542b\u91cf\u7684\u6d4b\u5b9a\u53ca\u5176\u81ea\u7531\u57fa\u6e05\u9664\u6d3b\u6027\u3002\u00a0\u98df\u54c1\u5316\u5b66\u3002\u00a0<\/span>2005;3<\/span>\uff1a571\u20137\u3002\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
28.\u00a0\u8c22Z\uff0c\u8d75Y\uff0c\u9648P\uff0c\u9759P\uff0c\u5cb3J\uff0c\u4f59L\u3002\u4e8c\u500d\u4f53\u548c\u56db\u500d\u4f53\u7ede\u80a1\u84dd\u53f6\u548c\u5168\u682a\u6837\u54c1\u7684\u8272\u8c31\u6307\u7eb9\u56fe\u8c31\u5206\u6790\u53ca\u82a6\u4e01\u548c\u69f2\u76ae\u7d20\u6210\u5206\u3002\u00a0\u519c\u4e1a\u98df\u54c1\u5316\u5b66\u6742\u5fd7\u3002\u00a0<\/span>2011;7<\/span>\uff1a3042\u20139\u3002 [\u8003\u7814<\/a>]\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
29.\u00a0Volpi N. \u9ad8\u6027\u80fd\u6bdb\u7ec6\u7ba1\u7535\u6cf3\u5728\u7eaf\u5316\u8fc7\u7a0b\u4e2d\u7684\u5e94\u7528\u00a0\u5927\u80a0\u6746\u83cc<\/em>\u00a0K4\u591a\u7cd6\u3002\u00a0J Chromatogr B.\u00a0<\/span>2004;2<\/span>\uff1a253\u20136\u3002 [\u8003\u7814<\/a>]\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n
30.\u00a0Ray B. \u6241\u6d52\u82d4\u591a\u7cd6\uff1a\u5206\u79bb\u3001\u7eaf\u5316\u548c\u7ed3\u6784\u7279\u5f81\u3002\u00a0\u78b3\u6c34\u5316\u5408\u7269\u805a\u5408\u7269\u3002\u00a0<\/span>2006;3<\/span>\uff1a408\u201316\u3002\u00a0[\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

Herba Polygoni Capitati, the aerial part or whole plant of Polygonum capitatum Buch.-Ham. ex D. Don, has been used as one of the Traditional Chinese Medicines (TCMs) for a long time in China, especially in some ethnic minority regions.<\/p>","protected":false},"author":1,"featured_media":5353,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9],"tags":[],"class_list":["post-5097","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-supplements"],"_links":{"self":[{"href":"https:\/\/directcm.com\/zh\/wp-json\/wp\/v2\/posts\/5097","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/directcm.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/directcm.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/directcm.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/directcm.com\/zh\/wp-json\/wp\/v2\/comments?post=5097"}],"version-history":[{"count":1,"href":"https:\/\/directcm.com\/zh\/wp-json\/wp\/v2\/posts\/5097\/revisions"}],"predecessor-version":[{"id":5380,"href":"https:\/\/directcm.com\/zh\/wp-json\/wp\/v2\/posts\/5097\/revisions\/5380"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/directcm.com\/zh\/wp-json\/wp\/v2\/media\/5353"}],"wp:attachment":[{"href":"https:\/\/directcm.com\/zh\/wp-json\/wp\/v2\/media?parent=5097"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/directcm.com\/zh\/wp-json\/wp\/v2\/categories?post=5097"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/directcm.com\/zh\/wp-json\/wp\/v2\/tags?post=5097"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}