{"id":5171,"date":"2024-01-16T11:01:40","date_gmt":"2024-01-16T11:01:40","guid":{"rendered":"https:\/\/farlong.com\/?p=5171"},"modified":"2024-01-27T10:30:11","modified_gmt":"2024-01-27T10:30:11","slug":"research-progress-on-pyroptosis-mediated-immune-inflammatory-response-in-ischemic-stroke-and-the-role-of-natural-plant-components-as-regulator-of-pyroptosis-a-review","status":"publish","type":"post","link":"https:\/\/directcm.com\/zh\/research-progress-on-pyroptosis-mediated-immune-inflammatory-response-in-ischemic-stroke-and-the-role-of-natural-plant-components-as-regulator-of-pyroptosis-a-review\/","title":{"rendered":"\u7f3a\u8840\u6027\u8111\u5352\u4e2d\u4ecb\u5bfc\u7684\u7ec6\u80de\u7126\u4ea1\u4ecb\u5bfc\u7684\u514d\u75ab\u708e\u75c7\u53cd\u5e94\u53ca\u5929\u7136\u690d\u7269\u6210\u5206\u5bf9\u7ec6\u80de\u7126\u4ea1\u8c03\u8282\u4f5c\u7528\u7684\u7814\u7a76\u8fdb\u5c55"},"content":{"rendered":"<div id=\"ab0015\" class=\"abstract author-highlights\">\n<h2 class=\"section-title u-h4 u-margin-l-top u-margin-xs-bottom\">\u5f3a\u8c03<\/h2>\n<div id=\"abs0015\">\n<ul>\n<li id=\"p0005\">\u672c\u6587\u5c31\u7f3a\u8840\u6027\u8111\u5352\u4e2d\u4e2d\u7ec6\u80de\u7126\u4ea1\u7684\u5206\u5b50\u673a\u5236\u7684\u6700\u65b0\u7814\u7a76\u8fdb\u5c55\u4f5c\u4e00\u7efc\u8ff0\u3002<\/li>\n<li id=\"p0010\">\u672c\u7efc\u8ff0\u603b\u7ed3\u4e86\u5929\u7136\u690d\u7269\u6210\u5206\u4f5c\u4e3a\u7f3a\u8840\u6027\u4e2d\u98ce\u4e2d\u7ec6\u80de\u7126\u4ea1\u8c03\u8282\u5242\u7684\u4f5c\u7528<\/li>\n<li id=\"p0015\">\u7f3a\u8840\u6027\u4e2d\u98ce\u4e2d\u7ec6\u80de\u7126\u4ea1\u7684\u8c03\u8282\u88ab\u63d0\u8bae\u4f5c\u4e3a\u4e00\u79cd\u6f5c\u5728\u7684\u6cbb\u7597\u7b56\u7565\u3002<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div id=\"ab0010\" class=\"abstract author\"><\/p>\n<h2><\/h2>\n<h2 class=\"section-title u-h4 u-margin-l-top u-margin-xs-bottom\">\u62bd\u8c61\u7684<\/h2>\n<div id=\"abs0010\">\n<p id=\"sp0030\"><a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI 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\u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8840\u6db2\u4f9b\u5e94\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascularity\">\u8840\u6db2\u4f9b\u5e94<\/a>\u00a0IS\u540e\u5c3d\u5feb\u901a\u8fc7\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8840\u6813\u6eb6\u89e3\u7597\u6cd5\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/fibrinolytic-therapy\">\u6eb6\u6813\u6cbb\u7597<\/a>\u00a0\u4fdd\u62a4\u795e\u7ecf\u5143\u7684\u6d3b\u529b\u548c\u529f\u80fd\u3002\u7136\u800c\uff0c\u8840\u6db2\u518d\u704c\u6ce8\u8fdb\u4e00\u6b65\u52a0\u901f\u7f3a\u8840\u635f\u4f24\uff0c\u9020\u6210\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u3002\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u7684\u75c5\u7406\u8fc7\u7a0b\u6d89\u53ca\u591a\u79cd\u673a\u5236\uff0c\u5177\u4f53\u673a\u5236\u5c1a\u672a\u5b8c\u5168\u9610\u660e\u3002\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7ec6\u80de\u7126\u4ea1\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyroptosis\">\u7126\u4ea1<\/a>\uff0c\u4e00\u79cd\u65b0\u53d1\u73b0\u7684\u708e\u75c7\u5f62\u5f0f\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/programmed-cell-death\">\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1<\/a>\uff0c\u5728\u708e\u75c7\u7684\u53d1\u751f\u548c\u8fdb\u5c55\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002\u8fd9\u662f\u4e00\u79cd\u4fc3\u708e\u75c7\u7a0b\u5e8f\u6027\u6b7b\u4ea1\uff0c\u7531\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 caspase \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/caspase\">\u80f1\u5929\u86cb\u767d\u9176<\/a>\u00a0Caspase-1\/4\/5\/11\u53ef\u5bfc\u81f4\u7ec6\u80de\u80bf\u80c0\u548c\u7834\u88c2\uff0c\u91ca\u653e\u708e\u75c7\u56e0\u5b50IL-1\u03b2\u548cIL-18\uff0c\u8bf1\u5bfc\u708e\u75c7\u7ea7\u8054\u53cd\u5e94\u3002\u8fd1\u5e74\u6765\u7814\u7a76\u8868\u660e\u7126\u4ea1\u53ca\u5176\u4ecb\u5bfc\u7684\u708e\u75c7\u53cd\u5e94\u662f\u52a0\u91cd\u7f3a\u8840\u6027\u8111\u635f\u4f24\u7684\u91cd\u8981\u56e0\u7d20\uff0c\u6291\u5236\u7126\u4ea1\u53ef\u80fd\u51cf\u8f7b\u7f3a\u8840\u6027\u8111\u635f\u4f24\u3002\u6b64\u5916\uff0c\u7814\u7a76\u53d1\u73b0\u5929\u7136\u690d\u7269\u6210\u5206\u53ef\u80fd\u5bf9\u7ec6\u80de\u7126\u4ea1\u5177\u6709\u8c03\u8282\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u672c\u6587\u4e0d\u4ec5\u5bf9\u7ec6\u80de\u7126\u4ea1\u7684\u5206\u5b50\u673a\u5236\u53ca\u5176\u5728\u7f3a\u8840\u6027\u4e2d\u98ce\u4e2d\u7684\u4f5c\u7528\u8fdb\u884c\u7efc\u8ff0\uff0c\u8fd8\u5bf9\u5929\u7136\u690d\u7269\u6210\u5206\u4f5c\u4e3a\u7ec6\u80de\u7126\u4ea1\u8c03\u8282\u5242\u7684\u4f5c\u7528\u8fdb\u884c\u7efc\u8ff0\uff0c\u4ee5\u671f\u4e3a\u7ec6\u80de\u7126\u4ea1\u63d0\u4f9b\u53c2\u8003\u4fe1\u606f\u3002\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6cbb\u7597\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/therapeutic-procedure\">\u6cbb\u7597<\/a>\u00a0IS \u7684\u672a\u6765\u3002<\/p>\n<div class=\"Keywords u-font-serif text-s\">\n<div id=\"keys0005\" class=\"keywords-section\">\n<h2 class=\"section-title u-h4 u-margin-l-top u-margin-xs-bottom\">\u5173\u952e\u8bcd<\/h2>\n<div id=\"key0005\" class=\"keyword\">\u7ec6\u80de\u7126\u4ea1\uff1b\u7f3a\u8840\u6027\u4e2d\u98ce\uff1b\u80f1\u5929\u86cb\u767d\u9176\uff1b\u5929\u7136\u690d\u7269\u6210\u5206\uff1b\u708e\u75c7\u5c0f\u4f53<\/div>\n<\/div>\n<\/div>\n<div id=\"body\" class=\"Body u-font-serif text-s\">\n<div>\n<section id=\"sec0005\">\n<h2 id=\"sect0025\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">1. \u7b80\u4ecb<\/h2>\n<p id=\"p0025\">\u968f\u7740\u4e16\u754c\u4eba\u53e3\u8001\u9f84\u5316\u7684\u52a0\u5267\uff0c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8111\u8840\u7ba1\u75be\u75c5\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebrovascular-disease\">\u8111\u8840\u7ba1\u75be\u75c5<\/a>\u00a0\uff08\u5982\u4e2d\u98ce\uff09\u5df2\u6210\u4e3a\u5168\u7403\u7b2c\u4e8c\u5927\u75be\u75c5\uff0c\u5bf9\u4eba\u7c7b\u7684\u5a01\u80c1\u65e5\u76ca\u52a0\u5927\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib1\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib1\"><span class=\"anchor-text\">[1]<\/span><\/a>\u3002\u884c\u7a0b\u5305\u62ec\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7f3a\u8840\u6027\u4e2d\u98ce\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/brain-ischemia\">\u7f3a\u8840\u6027\u4e2d\u98ce<\/a>\u00a0\uff08\u662f\uff09\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u51fa\u8840\u6027\u4e2d\u98ce\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebral-hemorrhage\">\u51fa\u8840\u6027\u4e2d\u98ce<\/a>\u9ad8\u8fbe 87% \u7684\u4e2d\u98ce\u662f\u7f3a\u8840\u6027\u7684\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib2\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib2\"><span class=\"anchor-text\">[2]<\/span><\/a>\u7279\u53d1\u6027\u810a\u9ad3\u708e\u662f\u4e34\u5e8a\u5e38\u89c1\u7684\u6025\u75c7\uff0c\u53d1\u75c5\u7387\u9010\u5e74\u4e0a\u5347\uff0c\u76ee\u524d\u4e34\u5e8a\u6cbb\u7597\u7279\u53d1\u6027\u810a\u9ad3\u708e\u7684\u65b9\u6cd5\u662f\u6062\u590d\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8840\u6db2\u4f9b\u5e94\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascularity\">\u8840\u6db2\u4f9b\u5e94<\/a>\u00a0IS\u540e\u5c3d\u5feb\u901a\u8fc7\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8840\u6813\u6eb6\u89e3\u7597\u6cd5\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/fibrinolytic-therapy\">\u6eb6\u6813\u6cbb\u7597<\/a>\u00a0\u4fdd\u62a4\u795e\u7ecf\u5143\u7684\u6d3b\u529b\u548c\u529f\u80fd\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib3\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib3\"><span class=\"anchor-text\">[3]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib4\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib4\"><span class=\"anchor-text\">[4]<\/span><\/a>\u3002\u7136\u800c\uff0c\u8840\u6d41\u6062\u590d\u540e\u7684\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\uff08IRI\uff09\u5f80\u5f80\u4f1a\u5bfc\u81f4\u66f4\u4e25\u91cd\u7684\u635f\u4f24\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8111\u7ec4\u7ec7\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-tissue\">\u8111\u7ec4\u7ec7<\/a>\u00a0\u548c\u795e\u7ecf\u7ec6\u80de\uff0c\u8fdb\u4e00\u6b65\u6210\u4e3a\u5bfc\u81f4\u60a3\u8005\u9884\u540e\u4e0d\u826f\u548c\u529f\u80fd\u969c\u788d\u7684\u91cd\u8981\u56e0\u7d20\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib5\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib5\"><span class=\"anchor-text\">[5]<\/span><\/a>\u3002\u6b64\u6b21\u5168\u7403\u6d41\u884c\u75c5\u5b66\u8c03\u67e5\u5206\u6790\u4e86\u5168\u7403204\u4e2a\u56fd\u5bb6\u548c\u5730\u533a1990\u5e74\u81f32019\u5e74\u7684\u6570\u636e\u3002\u4ed6\u4eec\u7684\u62a5\u544a\u6307\u51fa\uff0c\u4e2d\u98ce\u4ecd\u7136\u662f\u7b2c\u4e8c\u5927\u6b7b\u4ea1\u539f\u56e0\uff08\u5360\u603b\u6b7b\u4ea1\u4eba\u6570\u7684 11.6%\uff09\uff0c\u4e5f\u662f\u7b2c\u4e09\u5927\u6b7b\u4ea1\u548c\u6b8b\u75be\u539f\u56e0\uff08\u5360\u603b\u6b7b\u4ea1\u4eba\u6570\u7684 5.7%\uff09\u3002\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684\u4eba\u5de5\u667a\u80fd\u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6b8b\u75be\u8c03\u6574\u751f\u547d\u5e74\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/disability-adjusted-life-years\">\u4f24\u6b8b\u8c03\u6574\u751f\u547d\u5e74<\/a>\u00a0(DALYs)]\uff0c\u4ec5\u6b21\u4e8e\u00a0<a class=\"topic-link\" title=\"\u901a\u8fc7 ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u65b0\u751f\u513f\u75be\u75c5\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/newborn-disease\">\u65b0\u751f\u513f\u75be\u75c5<\/a>\u00a0\uff087.3% DALY\uff09\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7f3a\u8840\u6027\u5fc3\u810f\u75c5\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemic-heart-disease\">\u7f3a\u8840\u6027\u5fc3\u810f\u75c5<\/a>\u00a0\uff087.2% DALYs\uff09\uff0c\u4e14\u8111\u5352\u4e2d\u60a3\u8005\u6570\u91cf\u4ecd\u5728\u589e\u52a0\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib6\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib6\"><span class=\"anchor-text\">[6]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib7\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib7\"><span class=\"anchor-text\">[7]<\/span><\/a>\uff0c\u5c24\u5176\u662f\u5728\u4e2d\u56fd\u3002\u4e2d\u56fd\u5df2\u6210\u4e3a\u5168\u7403\u8111\u5352\u4e2d\u98ce\u9669\u6700\u9ad8\u7684\u56fd\u5bb6\uff0c\u5c45\u6c11\u8111\u5352\u4e2d\u98ce\u9669\u8fbe\u523039.3%\uff0c\u4e2d\u56fd\u7537\u6027\u8111\u5352\u4e2d\u98ce\u9669\u4e5f\u662f\u5168\u7403\u7537\u6027\u4e2d\u6700\u9ad8\uff0c\u8d85\u8fc741%\uff1b IS\u5df2\u4ece\u4e2d\u56fd\u5c45\u6c11\u7b2c\u4e09\u5927\u6b7b\u56e0\uff08\u622a\u81f31990\u5e74\uff09\u4e0a\u5347\u4e3a\u7b2c\u4e00\u5927\u6b7b\u56e0\uff08\u622a\u81f32017\u5e74\uff09\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib8\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib8\"><span class=\"anchor-text\">[8]<\/span><\/a>\u3002\u76ee\u524d\u7814\u7a76\u8ba4\u4e3a\u8111IRI\uff08CIRI\uff09\u7684\u75c5\u7406\u673a\u5236\u4e3b\u8981\u662f\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6c27\u5316\u5e94\u6fc0\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/oxidative-stress\">\u6c27\u5316\u5e94\u6fc0<\/a>\u00a0\u53d7\u4f24\uff0c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u708e\u75c7\u635f\u4f24\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammatory-injury\">\u708e\u6027\u635f\u4f24<\/a>\u3001\u7ebf\u7c92\u4f53\u635f\u4f24\u3001\u81ea\u566c\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7ec6\u80de\u51cb\u4ea1\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/programmed-cell-death\">\u7ec6\u80de\u51cb\u4ea1<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib9\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib9\"><span class=\"anchor-text\">[9]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib10\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib10\"><span class=\"anchor-text\">[10]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib11\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib11\"><span class=\"anchor-text\">[11]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib12\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib12\"><span class=\"anchor-text\">[12]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib13\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib13\"><span class=\"anchor-text\">[13]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib14\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib14\"><span class=\"anchor-text\">[14]<\/span><\/a>\u4f46\u8fd9\u4e9b\u8fd8\u4e0d\u8db3\u4ee5\u89e3\u91ca\u00a0<a class=\"topic-link\" title=\"\u901a\u8fc7 ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 CIRI \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunoreactive-insulin\">\u4e2d\u56fd\u5316\u5b66\u5de5\u4e1a\u7814\u7a76\u9662<\/a>\u3002\u4f8b\u5982\uff0cCIRI\u540e\u7684\u795e\u7ecf\u5143\u6b7b\u4ea1\u88ab\u8ba4\u4e3a\u4e3b\u8981\u662f\u7531\u7ec6\u80de\u51cb\u4ea1\u5f15\u8d77\u7684\uff0c\u795e\u7ecf\u7ec6\u80de\u4fdd\u62a4\u7684\u65b9\u5411\u4e3b\u8981\u662f\u6297\u51cb\u4ea1\u3002\u7136\u800c\uff0c\u7ec6\u80de\u51cb\u4ea1\u4e0e\u708e\u75c7\u5e76\u65e0\u76f4\u63a5\u5173\u7cfb\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib15\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib15\"><span class=\"anchor-text\">[15]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib16\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib16\"><span class=\"anchor-text\">[16]<\/span><\/a>\uff0c\u4f46 CIRI \u4e2d\u5b58\u5728\u663e\u7740\u7684\u708e\u75c7\u53cd\u5e94\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib16\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib16\"><span class=\"anchor-text\">[16]<\/span><\/a>\u56e0\u6b64\uff0c\u6709\u5fc5\u8981\u8fdb\u4e00\u6b65\u660e\u786eIS\u7684\u75c5\u7406\u751f\u7406\u673a\u5236\uff0c\u8fdb\u4e00\u6b65\u63a2\u8ba8CIRI\u7684\u75c5\u56e0\u3002<\/p>\n<p id=\"p0030\"><a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7ec6\u80de\u7126\u4ea1\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyroptosis\">\u7126\u4ea1<\/a>\uff0c\u4e5f\u79f0\u4e3a\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7ec6\u80de\u708e\u75c7\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammatory-cell\">\u7ec6\u80de\u708e\u75c7<\/a>\u00a0\u574f\u6b7b\uff0c\u662f\u8fd1\u5e74\u6765\u65b0\u53d1\u73b0\u5e76\u8bc1\u5b9e\u7684\u4e00\u79cd\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib17\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib17\"><span class=\"anchor-text\">[17]<\/span><\/a>. \u7ec6\u80de\u7126\u4ea1\u4f9d\u8d56\u4e8e\u708e\u75c7\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 caspase \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/caspase\">\u534a\u80f1\u5929\u51ac\u9176<\/a>\u00a0\uff08\u4e3b\u8981\u662fcaspase-1\u30014\u30015\u300111\uff09\u5e76\u4f34\u968f\u5927\u91cf\u4fc3\u708e\u56e0\u5b50\u7684\u91ca\u653e\uff0c\u8868\u73b0\u4e3a\u7ec6\u80de\u4e0d\u65ad\u6269\u5f20\u76f4\u81f3\u7ec6\u80de\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u819c\u7834\u88c2\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/membrane-rupture\">\u819c\u7834\u88c2<\/a>\u5bfc\u81f4\u7ec6\u80de\u5185\u5bb9\u7269\u7684\u91ca\u653e\u548c\u5f3a\u70c8\u7684\u708e\u75c7\u53cd\u5e94\u7684\u6fc0\u6d3b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib17\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib17\"><span class=\"anchor-text\">[17]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib18\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib18\"><span class=\"anchor-text\">[18]<\/span><\/a>\u3002\u8fd9\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e2d\u4e86\u89e3\u6709\u5173\u5f62\u6001\u7279\u5f81\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/morphological-trait\">\u5f62\u6001\u7279\u5f81<\/a>\u7ec6\u80de\u7126\u4ea1\u7684\u53d1\u751f\u548c\u8c03\u63a7\u673a\u5236\u4e0d\u540c\u4e8e\u51cb\u4ea1\u3001\u574f\u6b7b\u7b49\u5176\u4ed6\u7ec6\u80de\u6b7b\u4ea1\u65b9\u5f0f\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib18\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib18\"><span class=\"anchor-text\">[18]<\/span><\/a>\u7ec6\u80de\u7126\u4ea1\u5e7f\u6cdb\u53c2\u4e0e\u611f\u67d3\u6027\u75be\u75c5\u3001\u795e\u7ecf\u7cfb\u7edf\u76f8\u5173\u75be\u75c5\u3001\u52a8\u8109\u7ca5\u6837\u786c\u5316\u75be\u75c5\u3001\u6076\u6027\u80bf\u7624\u7b49\u591a\u79cd\u75be\u75c5\u7684\u53d1\u751f\u53d1\u5c55\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib19\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib19\"><span class=\"anchor-text\">[19]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib20\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib20\"><span class=\"anchor-text\">[20]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib21\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib21\"><span class=\"anchor-text\">[21]<\/span><\/a>\u6700\u65b0\u7814\u7a76\u8868\u660e\uff0c\u7ec6\u80de\u7126\u4ea1\u53ca\u5176\u4ecb\u5bfc\u7684\u708e\u75c7\u53cd\u5e94\u53c2\u4e0e\u4e86\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u75c5\u7406\u8fc7\u7a0b\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathological-process\">\u75c5\u7406\u8fc7\u7a0b<\/a>\u00a0\u6291\u5236IS\uff0c\u963b\u6b62\u7ec6\u80de\u7126\u4ea1\u7684\u6fc0\u6d3b\uff0c\u6709\u5229\u4e8e\u6291\u5236\u708e\u75c7\u7ea7\u8054\u53cd\u5e94\uff0c\u51cf\u8f7b\u7f3a\u8840\u6027\u8111\u635f\u4f24\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib22\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib22\"><span class=\"anchor-text\">[22]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib23\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib23\"><span class=\"anchor-text\">[23]<\/span><\/a>\u3002\u57fa\u4e8e\u6b64\uff0c\u7ec6\u80de\u7126\u4ea1\u7684\u7814\u7a76\u5bf9\u4e8e\u7ec6\u80de\u7126\u4ea1\u81f3\u5173\u91cd\u8981\u3002\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6cbb\u7597\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/therapeutic-procedure\">\u6cbb\u7597<\/a>\u00a0\u4fe1\u606f\u7cfb\u7edf\uff1b\u8c03\u8282\u7ec6\u80de\u7126\u4ea1\u53ef\u80fd\u964d\u4f4eIS\u7684\u75c5\u6b7b\u7387\uff0c\u63d0\u9ad8\u795e\u7ecf\u5143\u7684\u5b58\u6d3b\u7387\uff0c\u6539\u5584IS\u60a3\u8005\u7684\u75c7\u72b6\u3002\u73b0\u5728\uff0c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u836f\u7269\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chemotherapeutic-agent\">\u836f\u7269<\/a>\u00a0\u90a3\u4e2a\u53d1\u6325\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u795e\u7ecf\u4fdd\u62a4\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroprotective-agent\">\u795e\u7ecf\u4fdd\u62a4<\/a>\u00a0\u6b63\u5728\u5f00\u53d1\u901a\u8fc7\u8c03\u63a7\u7ec6\u80de\u7126\u4ea1\u9014\u5f84\u53d1\u6325\u5176\u4f5c\u7528\u7684\u65b0\u65b9\u6cd5\u3002\u7279\u522b\u662f\u5173\u4e8e\u5929\u7136\u690d\u7269\u6210\u5206\u8c03\u63a7IS\u8840\u7ba1\u795e\u7ecf\u5143\u5355\u5143\u7126\u4ea1\u7684\u7814\u7a76\u5f88\u591a\u3002\u6211\u4eec\u524d\u671f\u7684\u7814\u7a76\u4e5f\u8868\u660e\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7682\u82f7\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/saponin\">\u7682\u7519<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib24\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib24\"><span class=\"anchor-text\">[24]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib25\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib25\"><span class=\"anchor-text\">[25]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib26\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib26\"><span class=\"anchor-text\">[26]<\/span><\/a>\u00a0\u548c\u591a\u7ec4\u5206\u5316\u5408\u7269\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib27\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib27\"><span class=\"anchor-text\">[27]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib28\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib28\"><span class=\"anchor-text\">[28]<\/span><\/a>\u00a0\u53ef\u4ee5\u8c03\u8282\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u751f\u7269\u8fc7\u7a0b\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/biological-phenomena-and-functions-concerning-the-entire-organism\">\u751f\u7269\u8fc7\u7a0b<\/a>\u00a0IS \u4e2d\u7684\u7ec6\u80de\u7126\u4ea1\u3002\u56e0\u6b64\uff0c\u672c\u7efc\u8ff0\u4e0d\u4ec5\u603b\u7ed3\u4e86\u7ec6\u80de\u7126\u4ea1\u7684\u5206\u5b50\u673a\u5236\u53ca\u5176\u5728\u7f3a\u8840\u6027\u4e2d\u98ce\u4e2d\u7684\u4f5c\u7528\uff0c\u8fd8\u603b\u7ed3\u4e86\u5929\u7136\u690d\u7269\u6210\u5206\u4f5c\u4e3a\u7ec6\u80de\u7126\u4ea1\u8c03\u8282\u5242\u7684\u4f5c\u7528\uff0c\u4e3a\u672a\u6765\u7ec6\u80de\u7126\u4ea1\u76f8\u5173\u836f\u7269\u7684\u5f00\u53d1\u63d0\u4f9b\u5148\u5bfc\u5316\u5408\u7269\u6216\u5929\u7136\u690d\u7269\u6210\u5206\u3002<\/p>\n<\/section>\n<section id=\"sec0010\">\n<h2 id=\"sect0030\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">2. \u7ec6\u80de\u7126\u4ea1<\/h2>\n<section id=\"sec0015\">\n<h3 id=\"sect0035\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.1.\u7ec6\u80de\u7126\u4ea1\u7684\u7279\u70b9<\/h3>\n<div>\n<p id=\"p0035\"><a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7ec6\u80de\u7126\u4ea1\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyroptosis\">\u7126\u4ea1<\/a>\u00a0\u662f\u4e00\u79cd\u5f62\u5f0f\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/programmed-cell-death\">\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1<\/a>\u00a0\u4f9d\u8d56\u4fc3\u708e\u5242\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 caspase \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/caspase\">\u534a\u80f1\u5929\u51ac\u9176<\/a>\u5176\u7279\u70b9\u662f\u8de8\u819c\u5b54\u7684\u5f62\u6210\u3001\u7ec6\u80de\u819c\u7684\u80bf\u80c0\u548c\u7834\u88c2\u4ee5\u53ca\u4fc3\u708e\u5185\u5bb9\u7269\u7684\u91ca\u653e\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib29\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib29\"><span class=\"anchor-text\">[29]<\/span><\/a>\u3002\u7ec6\u80de\u51cb\u4ea1\u8fc7\u7a0b\u4e2d\uff0c\u7ec6\u80de\u6838\u788e\u88c2\uff0c\u7ec6\u80de\u819c\u5b8c\u6574\uff0c\u4e0d\u4f1a\u5f15\u8d77\u5468\u56f4\u7ec4\u7ec7\u7684\u708e\u75c7\u53cd\u5e94\uff0c\u800c\u7126\u4ea1\u8fc7\u7a0b\u4e2d\u7684\u7ec6\u80de\uff0c\u5177\u6709\u5b8c\u6574\u7684\u6838\u5f62\u6001\u548c\u7ec6\u80de\u7ed3\u6784\u3002\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u819c\u7834\u88c2\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/membrane-rupture\">\u80ce\u819c\u7834\u88c2<\/a>\uff0c\u5bfc\u81f4\u5468\u56f4\u708e\u75c7\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib30\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib30\"><span class=\"anchor-text\">[30]<\/span><\/a>\u3002\u5f53\u53d1\u751f\u7126\u4ea1\u65f6\uff0c\u7ec6\u80de\u819c\u4f1a\u9010\u6e10\u7834\u88c2\uff0c\u5f62\u62101~2 nm\u7684\u7ec6\u80de\u819c\u5b54\uff0c\u7136\u540e\u7ec6\u80de\u5185\u5bb9\u7269\u5982\u7ec6\u80de\u5185\u708e\u75c7\u56e0\u5b50\u7b49\u7269\u8d28\u91ca\u653e\u5230\u7ec6\u80de\u819c\u5916\u3002\u900f\u819c\u67d3\u6599\uff0c\u4f8b\u5982\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6eb4\u5316\u4e59\u952d\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ethidium-bromide\">\u6eb4\u5316\u4e59\u952d<\/a>\u00a0\u53ef\u7528\u4e8e\u89c2\u5bdf\u7ec6\u80de\u662f\u5426\u53d1\u751f\u7126\u4ea1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib31\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib31\"><span class=\"anchor-text\">[31]<\/span><\/a>\u6b64\u5916\uff0c\u574f\u6b7b\u7684\u53d1\u751f\u4f9d\u8d56\u4e8e\u6df7\u5408\u7cfb\u5217\u86cb\u767d\u6fc0\u9176\u6837\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u57df\u86cb\u767d\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/protein-domain\">\u7ed3\u6784\u57df\u86cb\u767d<\/a>\u00a0(MLKL)\uff0c\u5bf9\u8fdb\u5165\u7ec6\u80de\u7684\u79bb\u5b50\u6709\u9009\u62e9\u6027\uff0c\u6838\u67d3\u8272\u8d28\u5448\u7d6e\u72b6\u6216\u8fb9\u7f18\u805a\u96c6\u3002\u7126\u4ea1\u4f9d\u8d56\u4e8e\u6210\u5b54\u86cb\u767d GSDMD\uff0c\u8fd9\u662f\u4e00\u79cd\u975e\u9009\u62e9\u6027\u86cb\u767d\uff0c\u53ef\u5bfc\u81f4\u6838\u00a0<a class=\"topic-link\" title=\"\u901a\u8fc7 ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7ec6\u80de\u56fa\u7f29\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyknosis\">\u56fa\u7f29<\/a>\u00a0\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 DNA \u788e\u7247\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/dna-fragmentation\">DNA\u7247\u6bb5\u5316<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib32\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib32\"><span class=\"anchor-text\">[32]<\/span><\/a>\u3002\u7126\u4ea1\u3001\u7ec6\u80de\u51cb\u4ea1\u3001\u574f\u6b7b\u6027\u51cb\u4ea1\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u94c1\u6b7b\u4ea1\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ferroptosis\">\u94c1\u6b7b\u4ea1<\/a>\uff0c\u5982\u539f\u56e0\u3001\u7ec6\u80de\u53d8\u5316\u7b49\uff0c\u8be6\u60c5\u89c1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#tbl0005\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"tbl0005\"><span class=\"anchor-text\">\u8868\u683c1<\/span><\/a>.<\/p>\n<div id=\"tbl0005\" class=\"tables colsep-0 rowsep-0 frame-topbot\">\n<p id=\"sp0020\"><span class=\"label\">\u8868\u683c1<\/span>\u3002\u7126\u4ea1\u3001\u7ec6\u80de\u51cb\u4ea1\u548c\u574f\u6b7b\u6027\u51cb\u4ea1\u4e4b\u95f4\u7684\u5f02\u540c\u3002<\/p>\n<div class=\"groups\">\n<table>\n<thead>\n<tr class=\"rowsep-1\">\n<th scope=\"col\">\u7279\u5f81<\/th>\n<th scope=\"col\">\u7b7e\u540d\u7ec4\u4ef6<\/th>\n<th scope=\"col\">\u7ec6\u80de\u7684\u53d8\u5316<\/th>\n<th scope=\"col\">\u4e00\u822c\u539f\u56e0<\/th>\n<th scope=\"col\">\u6291\u5236\u5242<\/th>\n<th scope=\"col\">\u53c2\u8003<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<th scope=\"row\">\u7126\u4ea1<\/th>\n<td>\u7126\u78f7\u9178\u5316\u5c0f\u4f53\u3001\u708e\u75c7\u5c0f\u4f53<\/td>\n<td>\u5b54\u5f62\u6210\u3001\u7ec6\u80de\u80bf\u80c0\u3001\u8d28\u819c\u7834\u88c2\u3001\u67d3\u8272\u8d28\u6d53\u7f29\u3001DNA \u65ad\u88c2\u4f46\u6838\u5b8c\u6574\u6027\u7b49\u3002<\/td>\n<td>DAMP\u3001PAMP\u3001\u611f\u67d3<\/td>\n<td>GSDMD\u6291\u5236\u5242<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib19\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib19\"><span class=\"anchor-text\">[19]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib33\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib33\"><span class=\"anchor-text\">[33]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib34\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib34\"><span class=\"anchor-text\">[34]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib35\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib35\"><span class=\"anchor-text\">[35]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib36\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib36\"><span class=\"anchor-text\">[36]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u7ec6\u80de\u51cb\u4ea1<\/th>\n<td>\u51cb\u4ea1\u4f53<\/td>\n<td>\u7ec6\u80de\u6536\u7f29\uff0c\u819c\u5b8c\u6574\uff0c\u8d28\u819c\u8d77\u6ce1\uff0c\u67d3\u8272\u8d28\u51dd\u805a\uff0cDNA\u788e\u7247\u7b49\u3002<\/td>\n<td>\u751f\u7406\u72b6\u6001\u7684\u57fa\u56e0\u8c03\u63a7<\/td>\n<td>\u8c03\u8282caspase\u5bb6\u65cf\u3001Bcl-2\u5bb6\u65cf\u3001p53\u7b49\u3002<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib37\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib37\"><span class=\"anchor-text\">[37]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib38\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib38\"><span class=\"anchor-text\">[38]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib39\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib39\"><span class=\"anchor-text\">[39]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u574f\u6b7b\u6027\u51cb\u4ea1<\/th>\n<td>\u6b7b\u4f53<\/td>\n<td>\u7ec6\u80de\u80bf\u80c0\u3001\u8d28\u819c\u7834\u88c2\u3001\u7ec6\u80de\u5668\u80bf\u80c0\u3001\u67d3\u8272\u8d28\u6d53\u7f29\u7b49\u3002<\/td>\n<td>\u91cd\u4f24<\/td>\n<td>Nec-1\u3001NSA \u7b49<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib33\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib33\"><span class=\"anchor-text\">[33]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib40\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib40\"><span class=\"anchor-text\">[40]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib41\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib41\"><span class=\"anchor-text\">[41]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib42\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib42\"><span class=\"anchor-text\">[42]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib43\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib43\"><span class=\"anchor-text\">[43]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u94c1\u6b7b\u4ea1<\/th>\n<td>NRF2\u3001GPX4\u3001ACSL4 \u7b49<\/td>\n<td>\u4e3b\u8981\u53d1\u751f\u5728\u7ebf\u7c92\u4f53\uff0c\u7ebf\u7c92\u4f53\u5d74\u51cf\u5c11\uff0c\u819c\u6d53\u7f29\uff0c\u5916\u819c\u7834\u88c2\u3002<\/td>\n<td>Fe2+\u8d85\u8f7d\u548cROS<\/td>\n<td>GSH\u3001\u53bb\u94c1\u80fa\u3001\u5229\u666e\u53f8\u4ed6\u6c40-1\u3001\u94c1\u4ed6\u6c40-1\u7b49<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib44\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib44\"><span class=\"anchor-text\">[44]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib45\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib45\"><span class=\"anchor-text\">[45]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib46\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib46\"><span class=\"anchor-text\">[46]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib47\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib47\"><span class=\"anchor-text\">[47]<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section id=\"sec0020\">\n<h3 id=\"sect0040\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.2 \u7ec6\u80de\u7126\u4ea1\u7684\u5206\u5b50\u673a\u5236<\/h3>\n<p id=\"p0040\">\u7684\u5f62\u6210\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u708e\u75c7\u5c0f\u4f53\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammasome\">\u708e\u75c7\u5c0f\u4f53<\/a>\u00a0\u662f\u635f\u4f24\u540e\u7ec6\u80de\u7126\u4ea1\u7684\u5173\u952e\u7269\u8d28\uff0c\u673a\u4f53\u5728\u635f\u4f24\u65f6\u53ef\u6fc0\u6d3b\u4e0e\u75c5\u539f\u76f8\u5173\u5206\u5b50\u6a21\u5f0f\uff08PAMPs\uff09\u76f8\u5173\u7684\u6a21\u5f0f\u4fe1\u53f7\u548c\u4e0e\u635f\u4f24\u76f8\u5173\u5206\u5b50\u6a21\u5f0f\uff08DAMPs\uff09\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib48\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib48\"><span class=\"anchor-text\">[48]<\/span><\/a>. \u5f53\u4fe1\u53f7\u523a\u6fc0\u53d1\u751f\u65f6\uff0c\u7ec6\u80de\u5185\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u542f\u52a8\u5b50\u86cb\u767d\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/promoter-protein\">\u542f\u52a8\u5b50\u86cb\u767d<\/a>\u00a0\u6838\u82f7\u9178\u7ed3\u5408\u5be1\u805a\u5316\u7ed3\u6784\u57df\u6837\u53d7\u4f53\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5421\u5549\u7ed3\u6784\u57df\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyrin-domain\">\u5421\u5576\u7ed3\u6784\u57df<\/a>\u00a0\u542b\u67093\uff08NLRP3\uff09\u53ef\u4ee5\u5229\u7528\u708e\u6027\u5c0f\u4f53\u63a5\u5934\u5206\u5b50ASC\u901a\u8fc7\u5be1\u805a\u5316\u62db\u52df\u5927\u91cf\u7684procaspase-1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib49\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib49\"><span class=\"anchor-text\">[49]<\/span><\/a>\uff0c\u708e\u75c7\u5c0f\u4f53\u805a\u96c6\u86cb\u767d\u7684\u5f62\u6210\u3002Procaspase-1 \u662f caspase-1 \u7684\u524d\u4f53\uff0c\u6b63\u5e38\u60c5\u51b5\u4e0b\uff0cprocaspase-1 \u5728\u4f53\u5185\u4ee5\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u9176\u539f\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/enzyme-precursor\">\u9176\u539f<\/a>\u5f53\u523a\u6fc0\u4fe1\u53f7\u4f20\u9012\u5230 procaspase-1 \u65f6\uff0c\u5b83\u4f1a\u901a\u8fc7\u81ea\u6c34\u89e3\u751f\u6210 P20 \u548c P10 \u4e9a\u57fa\u3002\u8be5\u4e9a\u57fa\u9996\u5148\u5f62\u6210\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5f02\u4e8c\u805a\u4f53\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/heterodimer\">\u5f02\u4e8c\u805a\u4f53<\/a>\u00a0\u65e0\u6cd5\u53d1\u6325\u4f5c\u7528\uff0c\u7136\u540e\u805a\u96c6\u5f62\u6210\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u56db\u805a\u4f53\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tetramer\">\u56db\u805a\u4f53<\/a>\u00a0\u4fc3\u8fdb caspase-1 \u6d3b\u6027\uff0c\u5bfc\u81f4 caspase-1 \u6fc0\u6d3b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib50\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib50\"><span class=\"anchor-text\">[50]<\/span><\/a>\u3002\u5f53caspase-1\u88ab\u6fc0\u6d3b\u65f6\uff0c\u6d3b\u6027\u7684caspase-1\u8d1f\u8d23\u7ec6\u80de\u819c\u5b54\u7684\u5f62\u6210\uff0c\u5e76\u5feb\u901f\u88c2\u89e3\u7ec6\u80de\u819c\uff0c\u5f62\u6210\u708e\u75c7\u53cd\u5e94\u3002\u540c\u65f6\uff0ccaspase-1\u8fd8\u53ef\u4ee5\u8bf1\u5bfcIL-1\u03b2\u548cIL-18\u7684\u524d\u4f53pro-IL-1\u03b2\u548cpro-IL-18\u7684\u4ea7\u751f\uff0c\u52a0\u901f\u6210\u719f\u8fc7\u7a0b\u3002\u6210\u719f\u7684IL-1\u03b2\u548cIL-18\u88ab\u91ca\u653e\u5230\u7ec6\u80de\u5916\uff0c\u4ece\u800c\u52df\u96c6\u66f4\u591a\u7684\u708e\u6027\u4f53\u3002\u708e\u75c7\u5c0f\u4f53\u805a\u96c6\u540e\uff0c\u708e\u75c7\u53cd\u5e94\u8fdb\u4e00\u6b65\u52a0\u5267\uff0c\u7ec4\u7ec7\u635f\u4f24\u52a0\u91cd\u3002 IL-1\u03b2\u4ece\u7ec6\u80de\u4e2d\u91ca\u653e\u51fa\u6765\u540e\uff0c\u708e\u75c7\u56e0\u5b50\u968f\u7740\u6dcb\u5df4\u6db2\u7684\u6d41\u52a8\u6269\u6563\u5230\u90bb\u8fd1\u7ec4\u7ec7\uff0c\u8fdb\u4e00\u6b65\u52a0\u5267\u708e\u75c7\u53cd\u5e94\u3002\u5927\u91cfIL-18\u7684\u5206\u6ccc\u5f15\u8d77Th1\u548cTh2\u514d\u75ab\u53cd\u5e94\uff0c\u5e76\u523a\u6fc0\u514d\u75ab\u53cd\u5e94\u53d1\u6325\u4f5c\u7528\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib51\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib51\"><span class=\"anchor-text\">[51]<\/span><\/a>.<\/p>\n<section id=\"sec0025\">\n<h4 id=\"sect0045\" class=\"u-margin-m-top u-margin-xs-bottom\">2.2.1. \u5178\u578b\u7ec6\u80de\u7126\u4ea1\u9014\u5f84<\/h4>\n<p id=\"p0045\">Caspase-1\u662f\u7ecf\u5178\u7126\u4ea1\u9014\u5f84\u4e2d\u7684\u5173\u952e\u86cb\u767d\uff0c\u5176\u4e2d\u708e\u75c7\u5c0f\u4f53\u5728Caspase-1\u7684\u6fc0\u6d3b\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib52\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib52\"><span class=\"anchor-text\">[52]<\/span><\/a>\u3002\u708e\u75c7\u5c0f\u4f53\u662f\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\uff0c\u662f\u7531\u4f20\u611f\u5668\u86cb\u767d\u3001ASC\u548cpro-Caspase-1\u7ec4\u6210\u7684\u591a\u86cb\u767d\u590d\u5408\u7269\u3002\u5b83\u5b58\u5728\u4e8e\u53d7\u523a\u6fc0\u7684\u7ec6\u80de\u8d28\u4e2d\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u514d\u75ab\u7ec6\u80de\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunocompetent-cell\">\u514d\u75ab\u7ec6\u80de<\/a>\u00a0\u5e76\u80fd\u611f\u77e5\u7ec6\u80de\u5916\u523a\u6fc0\u4fe1\u53f7\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib53\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib53\"><span class=\"anchor-text\">[53]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib54\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib54\"><span class=\"anchor-text\">[54]<\/span><\/a>\u3002\u708e\u75c7\u5c0f\u4f53\u5206\u4e3a\u542b\u6709\u6838\u82f7\u9178\u7ed3\u5408\u5be1\u805a\u5316\u7ed3\u6784\u57df\u6837\u53d7\u4f53\uff08NLR\uff09\u7684\u708e\u75c7\u5c0f\u4f53\uff0c\u6458\u8981\u4e8e\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u9ed1\u8272\u7d20\u7624\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nodular-melanoma\">\u9ed1\u8272\u7d20\u7624<\/a>\u00a02 (AIM2) \u708e\u75c7\u5c0f\u4f53\u548c NLRC4 \u708e\u75c7\u5c0f\u4f53\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib55\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib55\"><span class=\"anchor-text\">[55]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib56\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib56\"><span class=\"anchor-text\">[56]<\/span><\/a>\u560c\u5464\u80fd 2\u00d77 (P2X7) \u53d7\u4f53\u662f\u4e00\u79cd ATP \u95e8\u63a7\u8de8\u819c\u79bb\u5b50\u901a\u9053\u53d7\u4f53\uff0c\u5728\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5c0f\u80f6\u8d28\u7ec6\u80de\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microglia\">\u5c0f\u80f6\u8d28\u7ec6\u80de<\/a>\u00a0\u662f\u708e\u75c7\u5c0f\u4f53\u6fc0\u6d3b\u7684\u5173\u952e\u56e0\u7d20\u3002\u7814\u7a76\u8868\u660e\uff0c\u7ec6\u80de\u5916 ATP \u53ef\u4ee5\u901a\u8fc7\u6fc0\u6d3b\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 P2X7 \u53d7\u4f53\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/purinergic-p2x7-receptor\">P2X7\u53d7\u4f53<\/a>\uff0c\u8bf1\u5bfcNLR\u5bb6\u65cf\u3001\u542b\u5421\u5576\u7ed3\u6784\u57df3\uff08NLRP3\uff09\u7684\u6fc0\u6d3b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib57\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib57\"><span class=\"anchor-text\">[57]<\/span><\/a>\u3002\u76ee\u524d\u7814\u7a76\u6700\u591a\u7684\u662fNLRP3\u708e\u75c7\u5c0f\u4f53\u3002 NLRP3 \u708e\u75c7\u5c0f\u4f53\u7684\u6fc0\u6d3b\u9700\u8981\u4e24\u6b65\u53cd\u5e94\uff1a\u542f\u52a8\u53cd\u5e94\u3001\u5fae\u751f\u7269\u6216\u5185\u6e90\u56e0\u5b50\u6838\u56e0\u5b50-\u03baB (NF-\u03baB) \u8fdb\u5165\u7ec6\u80de\u6838\uff0c\u4ee5\u53ca\u4e0a\u8c03 NLRP3 \u548c pro-IL-1\u03b2 \u8868\u8fbe\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib58\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib58\"><span class=\"anchor-text\">[58]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib59\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib59\"><span class=\"anchor-text\">[59]<\/span><\/a>\u3002\u5f53\u514d\u75ab\u7ec6\u80de\u53d7\u5230 DAMP \u523a\u6fc0\u65f6\uff0c\u4f20\u611f\u5668\u86cb\u767d\u901a\u8fc7 ASC \u52df\u96c6 pro-Caspase-1\uff0c\u7136\u540e\u901a\u8fc7\u81ea\u52a8\u6c34\u89e3\u5c06\u5176\u6fc0\u6d3b\u3002\u6210\u719f\u7684 Caspase-1 \u5c06\u4e0b\u6e38\u65e0\u6d3b\u6027\u7684 pro-IL-1\u03b2 \u548c pro-IL-18 \u52a0\u5de5\u6210\u6d3b\u6027\u7684 IL-1\u03b2 \u548c IL-18\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib60\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib60\"><span class=\"anchor-text\">[60]<\/span><\/a>\u3002\u540c\u65f6\uff0cCaspase-1\u5c06\u4e0b\u6e38GSDMD\u86cb\u767d\u5207\u5272\u6210\u5177\u6709\u6210\u5b54\u6d3b\u6027\u7684GSDMD-N\u7247\u6bb5\u548cGSDMD-C\u7247\u6bb5\u3002 GSDMD-N \u7247\u6bb5\u7279\u5f02\u6027\u8bc6\u522b\u5e76\u7ed3\u5408\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u819c\u8102\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/membrane-lipid\">\u819c\u8102<\/a>\u00a0\u7ec6\u80de\u819c\u5185\u4fa7\uff0c\u5f15\u8d77\u7ec6\u80de\u5185\u5916\u6e17\u900f\u538b\u53d8\u5316\uff0c\u5bfc\u81f4\u7ec6\u80de\u80bf\u80c0\u3001\u7834\u88c2\uff0c\u91ca\u653e\u708e\u75c7\u56e0\u5b50IL-1\u03b2\u548cIL-18\uff0c\u8bf1\u53d1\u708e\u75c7\u53cd\u5e94\u548c\u7ec6\u80de\u7126\u4ea1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib61\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib61\"><span class=\"anchor-text\">[61]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0030\">\n<h4 id=\"sect0050\" class=\"u-margin-m-top u-margin-xs-bottom\">2.2.2. \u975e\u7ecf\u5178\u7ec6\u80de\u7126\u4ea1\u9014\u5f84<\/h4>\n<p id=\"p0050\">Caspase\u5bb6\u65cf\u6839\u636e\u529f\u80fd\u4e0d\u540c\u4e3b\u8981\u5206\u4e3a\u51cb\u4ea1\u76f8\u5173\u548c\u708e\u75c7\u76f8\u5173\u4e24\u5927\u7c7b\uff0c\u5176\u4e2dCaspase-3\/2\/10\u4e3b\u8981\u4ecb\u5bfc\u7ec6\u80de\u51cb\u4ea1\uff0c\u800cCaspase-1\/4\/5\/11\u5219\u662f\u708e\u75c7\u548c\u5148\u5929\u514d\u75ab\u53cd\u5e94\u7684\u5173\u952e\u4ecb\u8d28\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib62\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib62\"><span class=\"anchor-text\">[62]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib63\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib63\"><span class=\"anchor-text\">[63]<\/span><\/a>\u3002\u975e\u7ecf\u5178\u7126\u4ea1\u9014\u5f84\u4f9d\u8d56\u4e8e Caspase-4\/5\/11 \u6fc0\u6d3b\uff0c\u800c\u708e\u75c7\u5c0f\u4f53\u5bf9\u4e8e IL-1\u03b2 \u548c IL-18 \u7684\u6210\u719f\u5e76\u4e0d\u662f\u5fc5\u9700\u7684\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib64\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib64\"><span class=\"anchor-text\">[64]<\/span><\/a>\u3002\u7126\u4ea1\u7684\u975e\u7ecf\u5178\u9014\u5f84\u662f\u7531\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8102\u591a\u7cd6\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/lipopolysaccharide\">\u8102\u591a\u7cd6<\/a>\u00a0\uff08LPS\uff09\uff0c\u9769\u5170\u6c0f\u9634\u6027\u7ec6\u83cc\u7684\u7ec6\u80de\u58c1\u6210\u5206\u3002LPS \u53ef\u76f4\u63a5\u4e0e\u4eba\u7c7b Caspase-4\/5 \u548c\u5c0f\u9f20 Caspase-11 \u7ed3\u5408\u3002\u8fd9\u4e9b\u80f1\u5929\u86cb\u767d\u9176\u65e2\u662f LPS \u7684\u4f20\u611f\u86cb\u767d\uff0c\u4e5f\u662f LPS \u7684\u6548\u5e94\u5206\u5b50\u3002\u6d3b\u5316\u7684 Caspase-4\/5\/11 \u53ef\u76f4\u63a5\u88c2\u89e3 GSDMD \u5e76\u8bf1\u5bfc\u7ec6\u80de\u7126\u4ea1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib65\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib65\"><span class=\"anchor-text\">[65]<\/span><\/a>\u6b64\u5916\uff0c\u7814\u7a76\u53d1\u73b0Caspase-11\u80fd\u591f\u6fc0\u6d3b\u4e0b\u6e38\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u95f4\u9699\u8fde\u63a5\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/gap-junction\">\u95f4\u9699\u8fde\u63a5<\/a>\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u901a\u9053\u86cb\u767d\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/channel-protein\">\u901a\u9053\u86cb\u767d<\/a>\u00a0Pannexin-1 \u4fc3\u8fdb K+ \u5916\u6d41\uff0cK+ \u5916\u6d41\u53ef\u6fc0\u6d3b NLRP3 \u708e\u75c7\u5c0f\u4f53\uff0c\u8fdb\u800c\u6fc0\u6d3b Caspase-1\uff0c\u4fc3\u8fdb IL-1\u03b2 \u548c IL-18 \u7684\u6210\u719f\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib66\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib66\"><span class=\"anchor-text\">[66]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0035\">\n<h4 id=\"sect0055\" class=\"u-margin-m-top u-margin-xs-bottom\">2.2.3. GSDMD\u4e0e\u7ec6\u80de\u7126\u4ea1\u7684\u5173\u7cfb<\/h4>\n<p id=\"p0055\">GSDMD\uff08Gsdermin D\uff09\u662f\u7531484\u4e2a\u6c28\u57fa\u9178\u6b8b\u57fa\u7247\u6bb5\u7ec4\u6210\u7684\u86cb\u767d\u8d28\uff0c\u5c5e\u4e8eGasdermin\u86cb\u767d\u5bb6\u65cf\u3002\u8be5\u5bb6\u65cf\u4e3b\u8981\u67095\u4e2a\u6210\u5458\uff0c\u5206\u522b\u662f\uff1aDFNA5\u3001DFNB59\u3001GSDMA\u3001GSDMB\u3001GSDMCD\u3002\u8fd95\u4e2a\u86cb\u767d\u8d28\u7684\u6c28\u57fa\u9178\u7ed3\u6784\u9ad8\u5ea6\u76f8\u4f3c\uff0c\u8fd9\u4e9b\u86cb\u767d\u8d28\u542b\u6709N\u7aef\u548cC\u7aef\u4e24\u4e2a\u7a7a\u95f4\u7ed3\u6784\u57df\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib67\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib67\"><span class=\"anchor-text\">[67]<\/span><\/a>\u3002 GSDMD \u86cb\u767d\u662f\u4e00\u79cd\u957f\u94fe\u6c28\u57fa\u9178\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u9178\u6027\u86cb\u767d\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/acid-protein\">\u9178\u6027\u86cb\u767d<\/a>\uff0c\u5176N\u7aef\u548cC\u7aef\u7ed3\u6784\u57df\u4e4b\u95f4\u7684\u7ed3\u6784\u76f8\u5bf9\u677e\u6563\u3002 GSDMD \u901a\u5e38\u5728\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6c28\u57fa\u9178\u5e8f\u5217\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/peptide-sequence\">\u6c28\u57fa\u9178\u5e8f\u5217<\/a>\u00a0275\uff0c\u66b4\u9732N\u672b\u7aef\u548cC\u672b\u7aef\u7ed3\u6784\u57df\u3002\u5728\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mammalian-cell\">\u54fa\u4e73\u52a8\u7269\u7ec6\u80de<\/a>\u7531\u4e8eGSDMD\u7684N\u7aef\u7ed3\u6784\u7b80\u5355\uff0c\u53ef\u4ee5\u8c03\u63a7\u7ec6\u80de\u7126\u4ea1\uff0c\u56e0\u6b64GSDMD\u5f80\u5f80\u53ea\u8868\u8fbeN\u7aef\u7ed3\u6784\u57df\uff0c\u800c\u4e0d\u80fd\u8868\u8fbe\u6240\u6709\u7684GSDMD\u86cb\u767d\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib68\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib68\"><span class=\"anchor-text\">[68]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib69\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib69\"><span class=\"anchor-text\">[69]<\/span><\/a>\u3002\u7136\u800c\u7814\u7a76\u8868\u660e\uff0c\u5f53\u5c06GSDMD\u7684N\u7aef\u7ed3\u6784\u57df\u5f15\u5165\u5927\u80a0\u6746\u83cc\u8fdb\u884c\u57f9\u517b\u65f6\uff0c\u4f1a\u4ea7\u751f\u5f3a\u70c8\u7684\u6bd2\u6027\u4f5c\u7528\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u5b8c\u6574\u7684GSDMD\u548cGSDMD\u7684C\u7aef\u7ed3\u6784\u57df\u8868\u73b0\u51fa\u76f8\u5bf9\u8f83\u4f4e\u7684\u6bd2\u6027\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib70\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib70\"><span class=\"anchor-text\">[70]<\/span><\/a>\u3002\u7ec6\u80de\u5185GSDMD\u7684N\u7aef\u7ed3\u6784\u4f1a\u968f\u7740\u635f\u4f24\u56e0\u5b50\u7684\u4fb5\u5165\u9010\u6e10\u8f6c\u79fb\u5230\u7ec6\u80de\u819c\u4e0a\uff0c\u5728\u7ec6\u80de\u819c\u4e0a\u4e0e\u78f7\u9178\u808c\u6c28\u9178\u9176\u7279\u5f02\u6027\u7ed3\u5408\uff0c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u78f7\u8102\u9170\u4e1d\u6c28\u9178\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/phosphatidylserine\">\u78f7\u8102\u9170\u4e1d\u6c28\u9178<\/a>\u00a0\u4f5c\u7528\u4e8e\u7ec6\u80de\u819c\u4ea7\u751f\u751f\u7269\u5b66\u6548\u5e94\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib71\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib71\"><span class=\"anchor-text\">[71]<\/span><\/a>. \u5229\u7528\u539f\u5b50\u529b\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7535\u5b50\u663e\u5fae\u955c\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/electron-microscopy\">\u7535\u5b50\u663e\u5fae\u955c<\/a>\u00a0\u548c\u4f4e\u6e29\u7535\u5b50\u663e\u5fae\u955c\u6280\u672f\uff0cL. Sborigi \u89c2\u5bdf\u5230 GSDMD \u7684 N \u7aef\u7ed3\u6784\u53ef\u4ee5\u4e0e\u751f\u7269\u819c\u7ed3\u5408\uff0c\u5728\u751f\u7269\u819c\u4e0a\u5f62\u6210\u4e2d\u7a7a\u7684\u73af\u72b6\u805a\u5408\u7269\u3002\u8be5\u805a\u5408\u7269\u8bf1\u5bfc\u751f\u7269\u819c\u5b54\u9699\u7684\u5f62\u6210\uff0c\u56e0\u6b64\u5f53\u5185\u6e90\u6027\u635f\u4f24\u53d1\u751f\u65f6\uff0cGSDMD \u4f1a\u8bf1\u5bfc\u7ec6\u80de\u7126\u4ea1\u3002\u5f53\u5916\u90e8\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u75c5\u539f\u4f53\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathogen\">\u75c5\u539f\u4f53<\/a>\u00a0\u5165\u4fb5\u65f6\uff0c\u5b83\u4eec\u80fd\u591f\u5438\u9644\u5728\u75c5\u539f\u4f53\u7684\u7ec6\u80de\u8868\u9762\uff0c\u901a\u8fc7\u6eb6\u89e3\u7ec6\u80de\u6765\u4fdd\u62a4\u8eab\u4f53\u514d\u53d7\u5916\u754c\u6709\u5bb3\u7269\u8d28\u7684\u4fb5\u5bb3\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib72\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib72\"><span class=\"anchor-text\">[72]<\/span><\/a>\u3002 GSDMD\u662f\u4e00\u79cd\u4e0ecaspase-1\/4\/5\/11\u4e0b\u6e38\u86cb\u767d\u7279\u5f02\u6027\u7ed3\u5408\u7684\u7269\u8d28\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u4fe1\u53f7\u8f6c\u5bfc\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/signal-transduction\">\u4fe1\u53f7\u8f6c\u5bfc<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib73\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib73\"><span class=\"anchor-text\">[73]<\/span><\/a>Caspase-1\u901a\u8fc7\u4e0e\u591a\u79cd\u86cb\u767d\u590d\u5408\u7269\u4ea7\u751f\u7684\u708e\u75c7\u5c0f\u4f53\u53cd\u5e94\uff0c\u4fc3\u4f7f\u4e0b\u6e38IL-1\u03b2\u548cIL-18\u91ca\u653e\u51fa\u7ec6\u80de\u819c\u3002\u6d3b\u5316\u7684caspase-1\u88c2\u89e3GSDMD\u86cb\u767d\uff0c\u5c06GSDMD\u8f6c\u5316\u4e3a\u6d3b\u6027\u80bd\u3002GSDMD\u7684\u5206\u89e3\u4ea7\u7269\u7279\u5f02\u6027\u5730\u4e0e\u7ec6\u80de\u819c\u7ed3\u5408\uff0c\u7ec6\u80de\u5916\u6c34\u5206\u5b50\u7b49\u6210\u5206\u901a\u8fc7\u7ec6\u80de\u819c\u5b54\u9699\u8fdb\u5165\u7ec6\u80de\u819c\uff0c\u5bfc\u81f4\u7ec6\u80de\u80bf\u80c0\u5e76\u6700\u7ec8\u7834\u88c2\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib74\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib74\"><span class=\"anchor-text\">[74]<\/span><\/a>.<\/p>\n<\/section>\n<\/section>\n<section id=\"sec0040\">\n<h3 id=\"sect0060\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.3 \u975e\u7f16\u7801RNA\u53c2\u4e0eIS\u4e2d\u7126\u4ea1\u57fa\u56e0\u7684\u8868\u8fbe<\/h3>\n<p id=\"p0060\">\u8fd1\u5e74\u6765\uff0c\u4e0e\u7126\u4ea1\u53d1\u751f\u76f8\u5173\u7684\u57fa\u56e0\u6c34\u5e73\u7684\u8c03\u63a7\u673a\u5236\u4e5f\u5f97\u5230\u4e86\u5145\u5206\u53d1\u5c55\u3002\u73b0\u4ee3\u5206\u5b50\u751f\u7269\u5b66\u7814\u7a76\u8868\u660e\uff0c\u57fa\u56e0\u7ec4\u768498%\u4e0d\u53c2\u4e0e\u7f16\u7801\u86cb\u767d\u8d28\u3002\u957f\u94fe\u7f16\u7801RNA\uff08lncRNA\uff09\u662f\u4e0d\u5177\u6709\u86cb\u767d\u8d28\u7f16\u7801\u529f\u80fd\u7684RNA\uff0c\u56e0\u5176\u957f\u5ea6\u8d85\u8fc7200\u4e2a\u6838\u82f7\u9178\u800c\u5f97\u540d\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib75\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib75\"><span class=\"anchor-text\">[75]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib76\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib76\"><span class=\"anchor-text\">[76]<\/span><\/a>\u3002 \u7136\u800c\uff0c\u5c3d\u7ba1\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 lncRNA \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/long-untranslated-rna\">\u957f\u94feRNA<\/a>\u00a0\u4e0d\u5177\u6709\u7f16\u7801\u86cb\u767d\u8d28\u7684\u529f\u80fd\uff0c\u662f\u4f53\u5185\u8868\u8fbe\u91cf\u6700\u591a\u7684\u57fa\u56e0\uff0c\u4e5f\u662f\u8f6c\u5f55\u6700\u4fdd\u5b88\u7684\u57fa\u56e0\u3002\u53c2\u4e0e\u673a\u4f53\u91cd\u8981\u7684\u75c5\u7406\u751f\u7406\u8fc7\u7a0b\uff0c\u7279\u522b\u662f\u5728\u518d\u704c\u6ce8\u635f\u4f24\u76f8\u5173\u75be\u75c5\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib77\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib77\"><span class=\"anchor-text\">[77]<\/span><\/a>\u7814\u7a76\u8868\u660e\uff0c\u5728\u5c0f\u80f6\u8d28\u7ec6\u80de\u4e2d\uff0clncRNA-H19\u7684\u8868\u8fbe\u6c34\u5e73\u4e0e\u518d\u704c\u6ce8\u6301\u7eed\u65f6\u95f4\u5448\u6b63\u76f8\u5173\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib78\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib78\"><span class=\"anchor-text\">[78]<\/span><\/a>. LncRNA-H19 \u7684\u8fc7\u8868\u8fbe\u901a\u8fc7\u4fc3\u8fdb\u4e0b\u6e38\u4fe1\u53f7\u5206\u5b50 NLRP3\/6 \u7684\u8868\u8fbe\u5e76\u542f\u52a8 GSDMD \u53d1\u6325\u708e\u75c7\u4f5c\u7528\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib79\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib79\"><span class=\"anchor-text\">[79]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib80\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib80\"><span class=\"anchor-text\">[80]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib81\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib81\"><span class=\"anchor-text\">[81]<\/span><\/a>. lncRNA-H19 \u80fd\u591f\u6fc0\u6d3b caspase \u86cb\u767d\u5bb6\u65cf\u6210\u5458\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib82\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib82\"><span class=\"anchor-text\">[82]<\/span><\/a>\uff0c\u5bfc\u81f4\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\uff0c\u53c2\u4e0e\u708e\u75c7\u5c0f\u4f53\u7684\u6fc0\u6d3b\uff0c\u5f15\u8d77\u795e\u7ecf\u5143\u635f\u4f24\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib83\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib83\"><span class=\"anchor-text\">[83]<\/span><\/a>\u9664\u4e86\u5206\u5b50\u7ed3\u6784\u7684\u8c03\u63a7\u5916\uff0clncRNA-H19\u8fd8\u80fd\u52df\u96c6\u66f4\u591a\u7684\u8f6c\u5f55\u56e0\u5b50\u6765\u8c03\u63a7mRNA\u7684\u8f6c\u5f55\u8fc7\u7a0b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib84\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib84\"><span class=\"anchor-text\">[84]<\/span><\/a>\u6b64\u5916\uff0clncRNA-H19 \u8fd8\u53ef\u4ee5\u4fc3\u8fdb\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6838\u8fd0\u8f93\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nucleocytoplasmic-transport\">\u6838\u8fd0\u8f93<\/a>\u00a0\u8f6c\u5f55\u56e0\u5b50\u7684\u8fc7\u7a0b\uff0c\u4ece\u800c\u589e\u52a0\u66f4\u591a\u9776\u57fa\u56e0\u7684\u7279\u5f02\u6027\u8868\u8fbe\uff0c\u5e76\u5728\u53d1\u751f\u65f6\u4ea7\u751f\u708e\u75c7\u7ea7\u8054\u7f51\u7edc\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7f3a\u8840\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemia\">\u7f3a\u8840<\/a>\u00a0\u53d1\u751f\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib84\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib84\"><span class=\"anchor-text\">[84]<\/span><\/a>\u3002\u56e0\u6b64\uff0clncRNA-H19\u662f\u4e00\u4e2a\u5f3a\u70c8\u7684\u5371\u9669\u4fe1\u53f7\u00a0<a class=\"topic-link\" title=\"\u901a\u8fc7 ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 CIRI \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunoreactive-insulin\">\u4e2d\u56fd\u5316\u5b66\u5de5\u4e1a\u7814\u7a76\u9662<\/a>\u00a0\u53d1\u751f\uff0c\u6291\u5236 H19 \u53ef\u80fd\u662f\u4e00\u4e2a\u6f5c\u5728\u7684\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6cbb\u7597\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/therapeutic-procedure\">\u6cbb\u7597<\/a>\u00a0\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib84\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib84\"><span class=\"anchor-text\">[84]<\/span><\/a>\u3002\u5728AIM2\u708e\u75c7\u5c0f\u4f53\u4ecb\u5bfc\u7684\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u4e2d\uff0clincRNA MEG3\/miR-485\/AIM2\u8f74\u5728CIRI\u671f\u95f4\u901a\u8fc7\u6fc0\u6d3bcaspase1\u4fe1\u53f7\u4f20\u5bfc\u4fc3\u8fdb\u7ec6\u80de\u7126\u4ea1\uff0c\u56e0\u6b64\u8be5\u8f74\u53ef\u80fd\u662f\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u7684\u6709\u6548\u6cbb\u7597\u9776\u70b9\u3002\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 IS \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/brain-ischemia\">\u662f<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib84\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib84\"><span class=\"anchor-text\">[84]<\/span><\/a>\u3002 \u4e3a\u4e86\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u514d\u75ab\u8c03\u8282\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunoregulation\">\u514d\u75ab\u8c03\u8282<\/a>\u00a0\u5c0f\u80f6\u8d28\u7ec6\u80de\uff0cWang \u7b49\u4eba\u3002\u53d1\u73b0 LncRNA-Fendrr \u53ef\u4ee5\u4fdd\u62a4\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6cdb\u7d20\u5316\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ubiquitination\">\u6cdb\u7d20\u5316<\/a>\u00a0\u5e76\u901a\u8fc7 HERC2 \u964d\u89e3 NLRC4 \u86cb\u767d\u5e76\u8c03\u8282\u5c0f\u80f6\u8d28\u7ec6\u80de\u7126\u4ea1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib85\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib85\"><span class=\"anchor-text\">[85]<\/span><\/a>Zhang \u7b49\u53d1\u73b0 lncRNA NEAT1\/miR-22\u20133p \u8f74\u53ef\u6291\u5236\u7ec6\u80de\u7126\u4ea1\u5e76\u51cf\u8f7b CIRI \u635f\u4f24\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib86\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib86\"><span class=\"anchor-text\">[86]<\/span><\/a>\u3002 IS\u540e\u4f53\u5916\u6c27\u7cd6\u5265\u593a\uff08OGD\uff09\u635f\u4f24\u5b9e\u9a8c\u8868\u660e\uff0cOGD\u589e\u52a0NOD\u6837\u53d7\u4f53\u86cb\u767d3\uff08NLRP3\uff09\u7684\u8868\u8fbe\uff0c\u8bf1\u5bfcNSC\u7126\u4ea1\uff0c\u5e76\u901a\u8fc7\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u9ad8\u538b\u6c27\u6cbb\u7597\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hyperbaric-medicine\">\u9ad8\u538b\u6c27\u7597\u6cd5<\/a>\u3002\u4e0a\u8c03\u7684lncRNA-H19\u5145\u5f53miR-423-5p\u7684\u5206\u5b50\u6d77\u7ef5\uff0c\u5728OGD\u540e\u9776\u5411NLRP3\u4ee5\u8bf1\u5bfc\u795e\u7ecf\u5e72\u7ec6\u80de\uff08NSC\uff09\u7126\u4ea1\u3002\u56e0\u6b64\uff0c\u8bc1\u5b9e\u9ad8\u538b\u6c27\u6cbb\u7597\u901a\u8fc7\u6291\u5236lncRNA-H19\/miR-423-5p\/NLRP3\u8f74\u6765\u4fdd\u62a4NSC\u514d\u4e8e\u7126\u4ea1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib87\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib87\"><span class=\"anchor-text\">[87]<\/span><\/a>\u3002 miR-21 \u662f\u4e00\u79cd\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 microRNA \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microrna\">\u5fae\u5c0fRNA<\/a>\u00a0\u4e0e\u7ec6\u80de\u7126\u4ea1\u53d1\u751f\u5bc6\u5207\u76f8\u5173\u7684miRNA\uff0c\u7814\u7a76\u8868\u660emiR-21\u80fd\u591f\u7279\u5f02\u6027\u8c03\u63a7NLRP3\u86cb\u767d\uff0c\u6fc0\u6d3bNLRP3\u86cb\u767d\uff0c\u523a\u6fc0NLRP3\u5206\u6ccc\uff0c\u5e76\u901a\u8fc7NF-\u03baB\u4fe1\u53f7\u901a\u8fc7\u708e\u75c7\u53cd\u9988\u901a\u8def\u5728\u5de8\u566c\u7ec6\u80de\u4e2d\u8868\u8fbe\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib88\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib88\"><span class=\"anchor-text\">[88]<\/span><\/a>\u3002 miR-21\u9664\u4e86\u6fc0\u6d3bNLRP3\u5916\uff0c\u8fd8\u53ef\u4ee5\u8c03\u8282\u4e0b\u6e38caspase-1\u7684\u6fc0\u6d3b\uff0c\u4fc3\u8fdbIL-1\u03b2\u7684\u5206\u6ccc\uff0c\u4fc3\u8fdb\u7ec6\u80de\u7126\u4ea1\u7684\u53d1\u751f\u3002\u5f53miR-21\u7f3a\u9677\u65f6\uff0cNLRP3\u8c03\u63a7\u7684caspase-1\u901a\u8def\u7684\u8868\u8fbe\u663e\u7740\u964d\u4f4e\u3002\u56e0\u6b64\uff0cmiR-21\u7684\u8868\u8fbe\u6c34\u5e73\u4e5f\u662f\u8c03\u63a7\u7ec6\u80de\u7126\u4ea1\u53d1\u751f\u7684\u5173\u952e\u73af\u8282\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib89\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib89\"><span class=\"anchor-text\">[89]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib90\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib90\"><span class=\"anchor-text\">[90]<\/span><\/a>\u3002\u73b0\u4ee3\u5206\u5b50\u751f\u7269\u5b66\u7814\u7a76\u8868\u660e\uff0cmiR-214-3p\u5177\u6709caspase-1\u7684\u7ed3\u5408\u4f4d\u70b9\uff0c\u53ef\u4ee5\u7279\u5f02\u6027\u7ed3\u5408caspase-1\u7684\u53d1\u751f\uff0c\u4ece\u800c\u8c03\u8282\u708e\u75c7\u53cd\u5e94\uff0c\u589e\u52a0\u7ec6\u80de\u7126\u4ea1\u7684\u53d1\u751f\u7387\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib91\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib91\"><span class=\"anchor-text\">[91]<\/span><\/a>.<\/p>\n<div>\n<p id=\"p0065\">\u7ec6\u80de\u7126\u4ea1\u7684\u5206\u5b50\u673a\u5236\u603b\u7ed3\u5982\u4e0b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#fig0005\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"fig0005\"><span class=\"anchor-text\">\u56fe\u30021<\/span><\/a>.<\/p>\n<figure id=\"fig0005\" class=\"figure text-xs\"><img decoding=\"async\" src=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr1.jpg\" alt=\"Fig. 1\" height=\"414\" aria-describedby=\"cap0005\" \/><\/p>\n<ol class=\"u-margin-s-bottom\">\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"\u4e0b\u8f7d\u9ad8\u5206\u8fa8\u7387\u56fe\u7247 (294KB)\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr1_lrg.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">\u4e0b\u8f7d \uff1a\u00a0<span class=\"download-link-title\">\u4e0b\u8f7d\u9ad8\u5206\u8fa8\u7387\u56fe\u7247 (294KB)<\/span><\/span><\/a><\/li>\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"\u4e0b\u8f7d\u5168\u5c3a\u5bf8\u56fe\u7247\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr1.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">\u4e0b\u8f7d \uff1a\u00a0<span class=\"download-link-title\">\u4e0b\u8f7d\u5168\u5c3a\u5bf8\u56fe\u7247<\/span><\/span><\/a><\/li>\n<\/ol>\n<p id=\"sp0005\"><span class=\"label\">\u56fe\u30021<\/span>\u3002\u7126\u4ea1\u7684\u5206\u5b50\u673a\u5236\uff08\u7126\u4ea1\u7684\u673a\u5236\u5305\u62ec\u7ecf\u5178\u708e\u75c7\u5c0f\u4f53\u9014\u5f84\u548c\u975e\u7ecf\u5178\u708e\u75c7\u5c0f\u4f53\u9014\u5f84\u3002\u7ecf\u5178\u708e\u75c7\u5c0f\u4f53\u9014\u5f84\u7531DAMPs\u6216PAMPs\u89e6\u53d1\u3002\u975e\u5178\u578b\u708e\u75c7\u5c0f\u4f53\u9014\u5f84\u7531\u7ec6\u80de\u5916\u9769\u5170\u6c0f\u9634\u6027\u83cc\u7684LPS\u89e6\u53d1\uff09\u6216\u6b7b\u4ea1\u523a\u6fc0\u3002\u89e6\u53d1\u540e\uff0c\u901a\u8fc7\u4e00\u7cfb\u5217\u5206\u5b50\u95f4\u76f8\u4e92\u4f5c\u7528\u89e6\u53d1\u7ec6\u80de\u7126\u4ea1\u3002\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 TLR \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/toll-like-receptor\">\u4fa7\u5411\u963b\u529b\u7cfb\u6570<\/a>\uff1aToll \u6837\u53d7\u4f53\uff1b GSDM\uff1aGsdermin\uff1b NLRP3\uff1a\u6838\u82f7\u9178\u7ed3\u5408\u5be1\u805a\u5316\u7ed3\u6784\u57df\u6837\u53d7\u4f53\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5421\u5549\u7ed3\u6784\u57df\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pyrin-domain\">\u5421\u5576\u7ed3\u6784\u57df<\/a>\u00a0\u5305\u542b3\uff1bDAMP\uff1a\u635f\u4f24\u76f8\u5173\u5206\u5b50\u6a21\u5f0f\uff1bPAMP\uff1a\u75c5\u539f\u4f53\u76f8\u5173\u5206\u5b50\u6a21\u5f0f\uff09\u3002<\/p>\n<\/figure>\n<\/div>\n<\/section>\n<section id=\"sec0045\">\n<h3 id=\"sect0065\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.4 \u7ec6\u80de\u7126\u4ea1\u4e0e\u5176\u4ed6\u7ec6\u80de\u635f\u4f24\u7684\u5173\u7cfb<\/h3>\n<p id=\"p0070\">\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u7684\u53d1\u751f\u673a\u5236\u6709\u5f88\u591a\uff0c\u5df2\u77e5\u7684\u673a\u5236\u4e0e\u708e\u75c7\u53cd\u5e94\u3001\u9499\u901a\u9053\u969c\u788d\u3001\u7ebf\u7c92\u4f53\u529f\u80fd\u53d7\u635f\u3001\u81ea\u566c\u7b49\u591a\u79cd\u673a\u5236\u6709\u5173\uff0c\u800c\u7ec6\u80de\u7126\u4ea1\u53c2\u4e0e\u4e86\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u7684\u5404\u4e2a\u73af\u8282\uff0c\u4e0e\u5176\u4ed6\u635f\u4f24\u5bc6\u5207\u76f8\u5173\u3002<\/p>\n<p id=\"p0075\">\u7ec6\u80de\u7126\u4ea1\u4e0e\u51cb\u4ea1\u90fd\u5c5e\u4e8e\u7ec6\u80de\u6b7b\u4ea1\u7684\u4e00\u79cd\u65b9\u5f0f\uff0c\u4f46\u4e8c\u8005\u6709\u7740\u672c\u8d28\u7684\u533a\u522b\uff0c\u51cb\u4ea1\u662f\u751f\u7406\u6027\u7684\u7ec6\u80de\u6b7b\u4ea1\u65b9\u5f0f\uff0c\u800c\u7ec6\u80de\u7126\u4ea1\u5f80\u5f80\u4f34\u968f\u673a\u4f53\u635f\u4f24\u540e\u7684\u75c5\u7406\u6027\u7ec6\u80de\u6b7b\u4ea1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib92\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib92\"><span class=\"anchor-text\">[92]<\/span><\/a>\u3002\u81ea\u566c\u662f\u5e7f\u6cdb\u5b58\u5728\u4e8e\u751f\u7269\u4f53\u4e2d\u7684\u4e00\u79cd\u81ea\u566c\u73b0\u8c61\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u771f\u6838\u7ec6\u80de\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/eukaryotic-cell\">\u771f\u6838\u7ec6\u80de<\/a>\u3002\u81ea\u566c\u4e00\u822c\u5206\u4e3a\u4e09\u79cd\u7c7b\u578b\uff0c\u5373\u5206\u5b50\u4f34\u4fa3\u4ecb\u5bfc\u7684\u81ea\u566c\u3001\u5fae\u81ea\u566c\u548c\u5de8\u81ea\u566c\u3002\u76ee\u524d\u5173\u4e8e\u5de8\u81ea\u566c\u7684\u7814\u7a76\u8f83\u591a\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib93\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib93\"><span class=\"anchor-text\">[93]<\/span><\/a>\u81ea\u566c\u662f\u7ec6\u80de\u6b63\u5e38\u4ee3\u8c22\u8fc7\u7a0b\u4e2d\u4e0d\u53ef\u7f3a\u5c11\u7684\u4e00\u90e8\u5206\uff0c\u81ea\u566c\u6291\u5236\u53ef\u5bfc\u81f4\u6709\u5bb3\u7269\u8d28\u5728\u7ec4\u7ec7\u3001\u5668\u5b98\u6216\u7ec6\u80de\u5185\u84c4\u79ef\uff0c\u800c\u81ea\u566c\u8fc7\u5ea6\u6fc0\u6d3b\u5219\u4f1a\u7834\u574f\u7ec6\u80de\u5185\u91cd\u8981\u7ec6\u80de\u5668\u548c\u5fc5\u9700\u86cb\u767d\u8d28\uff0c\u5f15\u53d1\u81ea\u566c\u6027\u51cb\u4ea1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib94\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib94\"><span class=\"anchor-text\">[94]<\/span><\/a>.<\/p>\n<p id=\"p0080\">\u7ec6\u80de\u7126\u4ea1\u548c\u81ea\u566c\u6709\u7740\u5343\u4e1d\u4e07\u7f15\u7684\u8054\u7cfb\u3002\u6b63\u5e38\u60c5\u51b5\u4e0b\uff0c\u4f53\u5185\u81ea\u566c\u548c\u7ec6\u80de\u7126\u4ea1\u7684\u53d1\u751f\u5904\u4e8e\u52a8\u6001\u5e73\u8861\u72b6\u6001\u3002\u5f53\u8eab\u4f53\u5bf9\u5916\u90e8\u523a\u6fc0\u4ea7\u751f\u708e\u75c7\u53cd\u5e94\u65f6\uff0c\u81ea\u566c\u548c\u7ec6\u80de\u7126\u4ea1\u4e4b\u95f4\u7684\u5e73\u8861\u5c31\u4f1a\u88ab\u7834\u574f\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib95\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib95\"><span class=\"anchor-text\">[95]<\/span><\/a>\u3002\u4f8b\u5982\uff0cNF-\u03baB \u662f\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u4fe1\u53f7\u8f6c\u5bfc\u9014\u5f84\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/signal-transduction-pathway\">\u4fe1\u53f7\u8f6c\u5bfc\u901a\u8def<\/a>\u00a0\u53c2\u4e0e\u8bb8\u591a\u4fe1\u53f7\u8f6c\u5bfc\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u4fe1\u53f7\u901a\u8def\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-signaling-pathway\">\u4fe1\u53f7\u901a\u8def<\/a>\u00a0\u6765\u5b9e\u73b0\u4fe1\u53f7\u4f20\u5bfc\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u6572\u9664 NF-\u03baB \u57fa\u56e0\u7684 IS \u5c0f\u9f20\u4e2d\uff0c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 mTOR \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mammalian-target-of-rapamycin\">\u7c73\u6258<\/a>\u00a0\u6d3b\u6027\u53d7\u5230\u6291\u5236\uff0c\u81ea\u566c\u6c34\u5e73\u589e\u5f3a\u3002 NF-\u03baB\u4fe1\u53f7\u6fc0\u6d3b\u9014\u5f84\u662f\u5927\u91cf\u523a\u6fc0\u6fc0\u6d3bNF-\u03baB\u8bf1\u5bfc\u7684\u6fc0\u9176\uff0c\u4ece\u800c\u6fc0\u6d3bI\u03baK\u03b1\u3001I\u03baKB\u548cI\u03baK\u03b3\u4e09\u805a\u4f53\uff0c\u5bfc\u81f4I\u03baB\u78f7\u9178\u5316\u548c\u964d\u89e3\uff0c\u6700\u7ec8\u6fc0\u6d3bNF-\u03baB\u4fe1\u53f7\u901a\u8def\u3002\u6fc0\u6d3b\u540e\uff0cNF-\u03baB\u8fdb\u5165\u7ec6\u80de\u5185\u5e76\u4e0e\u5176\u76f8\u5e94\u7684DNA\u53d7\u4f53\u7279\u5f02\u6027\u7ed3\u5408\uff0c\u4ece\u800c\u523a\u6fc0\u708e\u75c7\u56e0\u5b50\u7684\u8f6c\u5f55\uff0c\u4fc3\u8fdb\u708e\u75c7\u56e0\u5b50TNF-\u03b1\u3001IL-1\u03b2\u548cIL-6\u7684\u5927\u91cf\u8868\u8fbe\u3002\u7814\u7a76\u8868\u660e\uff0cNF-\u03baB\u4fe1\u53f7\u901a\u8def\u53c2\u4e0e\u8c03\u8282\u5173\u952e\u7126\u4ea1\u86cb\u767dNLRP3\u8f6c\u5f55\u524d\u548c\u8f6c\u5f55\u540e\u6c34\u5e73\u7684\u6fc0\u6d3b\uff0c\u4ece\u800c\u8bf1\u5bfc\u7126\u4ea1\u3002\u5927\u91cf\u8868\u8fbe\u7684\u708e\u75c7\u56e0\u5b50\u53ef\u80fd\u8bf1\u53d1\u4f53\u5185\u708e\u75c7\u7ea7\u8054\u53cd\u5e94\uff0c\u8bf1\u53d1\u7ec6\u80de\u7126\u4ea1\uff0c\u8fdb\u4e00\u6b65\u6269\u5927\u708e\u75c7\u53cd\u5e94\uff0c\u4ece\u800c\u52a0\u91cd\u8111\u635f\u4f24\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib96\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib96\"><span class=\"anchor-text\">[96]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib97\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib97\"><span class=\"anchor-text\">[97]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib98\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib98\"><span class=\"anchor-text\">[98]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0050\">\n<h3 id=\"sect0070\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.5. IS \u6d89\u53ca\u7684\u7126\u4ea1\u548c\u708e\u75c7\u673a\u5236<\/h3>\n<p id=\"p0085\">\u708e\u75c7\u7ea7\u8054\u53cd\u5e94\u5b58\u5728\u4e8e IS \u7684\u5404\u4e2a\u9636\u6bb5\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib99\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib99\"><span class=\"anchor-text\">[99]<\/span><\/a>\u5728IS\u7684\u65e9\u671f\u9636\u6bb5\uff0c\u5927\u8111\u8840\u6d41\u51cf\u6162\uff0c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u4e2d\u6027\u7c92\u7ec6\u80de\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neutrophil\">\u4e2d\u6027\u7c92\u7ec6\u80de<\/a>\u00a0\u575a\u6301\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5185\u76ae\u7ec6\u80de\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/endothelial-cell\">\u5167\u76ae\u7d30\u80de<\/a>\u00a0\u7f3a\u8840\u8840\u7ba1\uff0c\u5e76\u5f00\u59cb\u6700\u521d\u7684\u6025\u6027\u708e\u75c7\u53cd\u5e94\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib100\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib100\"><span class=\"anchor-text\">[100]<\/span><\/a>\u968f\u7740\u8111\u7f3a\u8840\u540e\u518d\u704c\u6ce8\u7684\u53d1\u751f\uff0c\u5916\u6e90\u6027\u708e\u75c7\u56e0\u5b50\u3001\u708e\u75c7\u7ec6\u80de\u53ca\u708e\u75c7\u56e0\u5b50\u901a\u8fc7\u8840\u8111\u5c4f\u969c\uff0c\u4ea7\u751f\u518d\u704c\u6ce8\u540e\u7f3a\u8840\u7684\u4e8c\u6b21\u6548\u5e94\uff0c\u5bfc\u81f4\u5927\u91cf\u6c27\u5316\u56e0\u5b50\u7684\u91ca\u653e\u53ca\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u81ea\u7531\u57fa\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/radical-chemistry\">\u81ea\u7531\u57fa<\/a>\u6b64\u65f6\uff0c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8111\u7ec4\u7ec7\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-tissue\">\u8111\u7ec4\u7ec7<\/a>\u00a0\u9010\u6e10\u5927\u91cf\u6fc0\u6d3b\u5e76\u4ea7\u751f\u66f4\u591a\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u708e\u75c7\u4ecb\u8d28\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammatory-mediator\">\u708e\u75c7\u4ecb\u8d28<\/a>\u8fd9\u7c7b\u708e\u75c7\u4ecb\u8d28\u53ef\u4ee5\u8fc7\u5ea6\u6fc0\u6d3b\u8111\u7ec4\u7ec7\u5185\u76ae\u7ec6\u80de\uff0c\u4ea7\u751f\u5927\u91cf\u7684\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7ec4\u7ec7\u56e0\u5b50\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/thromboplastin\">\u7ec4\u7ec7\u56e0\u5b50<\/a>\u00a0\u79ef\u7d2f\u6c28\u57fa\u9178\u7684\u6bd2\u6027\u3002\u8fd9\u8fdb\u4e00\u6b65\u52a0\u5267\u4e86\u6c27\u5316\u56e0\u5b50\u3001\u81ea\u7531\u57fa\u7684\u91ca\u653e\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u4e00\u6c27\u5316\u78b3\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/carbon-monoxide\">\u4e00\u6c27\u5316\u78b3<\/a>\u5e76\u6fc0\u6d3b\u708e\u75c7\u53cd\u5e94\u76f8\u5173\u4fe1\u53f7\u901a\u8def\uff0c\u5982 NF-\u03baB\u3001Toll \u6837\u53d7\u4f53\u548c Nod \u6837\u53d7\u4f53 (NLR)\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib101\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib101\"><span class=\"anchor-text\">[101]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib102\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib102\"><span class=\"anchor-text\">[102]<\/span><\/a>\u3002\u6bd4\u5982NLRs\uff0c\u7814\u7a76\u8868\u660eNLRs\u670923\u4e2a\u5bb6\u65cf\u6210\u5458\uff0c\u4e3b\u8981\u8868\u8fbe\u4e8e\u7ec6\u80de\u80de\u6d46\u4e2d\uff0c\u5728\u673a\u4f53\u5148\u5929\u514d\u75ab\u53cd\u5e94\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u3002 NLR \u5bb6\u65cf\u7684\u6210\u5458 Nalp1\u3001Nalp3\u3001Nalp5 \u548c Ipaf \u80fd\u591f\u901a\u8fc7\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8854\u63a5\u86cb\u767d\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/adaptor-protein\">\u8854\u63a5\u86cb\u767d<\/a>\u00a0ASC\uff0c\u5f15\u53d1\u4e00\u7cfb\u5217\u708e\u75c7\u53cd\u5e94\uff0c\u5e76\u4ecb\u5bfc\u7ec6\u80de\u7126\u4ea1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib103\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib103\"><span class=\"anchor-text\">[103]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib104\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib104\"><span class=\"anchor-text\">[104]<\/span><\/a>\u3002 NLRP3\u662f\u708e\u75c7\u56e0\u5b50\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\u3002 NLRP3\u5305\u542b\u4e09\u4e2a\u7ed3\u6784\u57df\uff1aPYD\u3001NACHT\u548cLRR\uff0c\u53ef\u4ee5\u7528LRR-NACHT-PYD\uff1aPYD-CARD\uff1aCARD-CARDC\u8868\u793aspase\u7ed3\u6784\u57df\u3002\u5b83\u5bf9\u5185\u6e90\u6027\u635f\u4f24\u7684\u5404\u79cd\u4fe1\u53f7\u505a\u51fa\u53cd\u5e94\uff0c\u56e0\u6b64NLRP3\u708e\u75c7\u5c0f\u4f53\u7684\u6fc0\u6d3b\u88ab\u8ba4\u4e3a\u662f\u7ec6\u80de\u7126\u4ea1\u7684\u4e3b\u8981\u7c7b\u578b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib105\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib105\"><span class=\"anchor-text\">[105]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib106\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib106\"><span class=\"anchor-text\">[106]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib107\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib107\"><span class=\"anchor-text\">[107]<\/span><\/a>.<\/p>\n<p id=\"p0090\">\u708e\u75c7\u5c0f\u4f53\u662f\u8eab\u4f53\u6536\u5230\u611f\u67d3\u6216\u7ec6\u80de\u635f\u4f24\u4fe1\u53f7\u540e\u7ec4\u88c5\u7684\u86cb\u767d\u8d28\u590d\u5408\u7269\uff0c\u662f\u62db\u52df\u548c\u6fc0\u6d3b caspase-1 \u524d\u4f53\u7684\u5e73\u53f0\u3002\u542f\u52a8\u5b50\u86cb\u767dNLRP3\u53ef\u4ee5\u4f7f\u7528\u708e\u6027\u5c0f\u4f53\u63a5\u5934\u5206\u5b50ASC\u901a\u8fc7\u5be1\u805a\u5316\u62db\u52df\u5927\u91cf\u7684procaspase-1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib108\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib108\"><span class=\"anchor-text\">[108]<\/span><\/a>\u3002 Procaspase-1\u662fcaspase-1\u7684\u524d\u4f53\uff0c\u6d3b\u6027\u7684caspase-1\u8d1f\u8d23\u5feb\u901f\u88c2\u89e3\u7ec6\u80de\uff0c\u6fc0\u6d3b\u5e76\u91ca\u653e\u7ec6\u80de\u5916IL-1\u03b2\u548cIL-18\uff0c\u8fdb\u4e00\u6b65\u52a0\u5267\u708e\u75c7\u53cd\u5e94\u3002\u56e0\u6b64\uff0c\u7126\u4ea1\u7684\u53d1\u751f\u4e0e\u708e\u75c7\u53cd\u5e94\u7684\u51fa\u73b0\u548c\u708e\u75c7\u5c0f\u4f53\u7684\u5f62\u6210\u5bc6\u5207\u76f8\u5173\u3002\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u7684\u53d1\u751f\u4e0e\u7ec6\u80de\u7126\u4ea1\u548c\u708e\u75c7\u53cd\u5e94\u7684\u76f8\u4e92\u4f5c\u7528\u66f4\u4e3a\u5bc6\u5207\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib109\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib109\"><span class=\"anchor-text\">[109]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib110\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib110\"><span class=\"anchor-text\">[110]<\/span><\/a>\u7279\u522b\u662f\u5728\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff0c\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u8bf1\u5bfc\u5c0f\u80f6\u8d28\u7ec6\u80de\u7684\u6d3b\u5316\u548c\u589e\u6b96\uff0c\u4ea7\u751f\u5927\u91cf\u7684\u708e\u75c7\u4ecb\u8d28\uff0c\u8fd9\u4e9b\u708e\u75c7\u4ecb\u8d28\u53ef\u4ee5\u6fc0\u6d3b\u5185\u76ae\u7ec6\u80de\uff0c\u4ea7\u751f\u591a\u79cd\u7ec4\u7ec7\u56e0\u5b50\uff0c\u589e\u52a0\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5174\u594b\u6027\u6c28\u57fa\u9178\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/excitatory-amino-acid\">\u5174\u594b\u6027\u6c28\u57fa\u9178<\/a>\u5e76\u63a8\u52a8\u91ca\u653e\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u4e00\u6c27\u5316\u6c2e\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nitric-oxide\">\u4e00\u6c27\u5316\u6c2e<\/a>\u00a0\u548c\u6c27\u81ea\u7531\u57fa\u3002\u4e0a\u8ff0\u7269\u8d28\u8fdb\u4e00\u6b65\u5bfc\u81f4NF-\u03baB\u3001JNK2\/STAT3\u7b49\u591a\u79cd\u708e\u75c7\u4fe1\u53f7\u8f6c\u5bfc\u901a\u8def\u7684\u6fc0\u6d3b\uff0c\u4fc3\u8fdbNLRP1\u3001NLRP3\u7b49\u708e\u75c7\u5c0f\u4f53\u7684\u7ec4\u88c5\u3002\u6fc0\u6d3b\u7684caspase-1\u8bf1\u5bfc\u7ec6\u80de\u7126\u4ea1\uff0c\u6269\u5927\u708e\u75c7\u53cd\u5e94\uff0c\u52a0\u91cd\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib111\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib111\"><span class=\"anchor-text\">[111]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib112\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib112\"><span class=\"anchor-text\">[112]<\/span><\/a>\u6709\u7814\u7a76\u53d1\u73b0\uff0c\u4e0e\u91ce\u751f\u578b\u5c0f\u9f20\u76f8\u6bd4\uff0cAIM2\u5c0f\u9f20\u8111\u5185AIM2\u548cIL-1\u03b2\u7684\u6c34\u5e73\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u57fa\u56e0\u6572\u9664\u5c0f\u9f20\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/knockout-mouse\">\u57fa\u56e0\u6572\u9664\u5c0f\u9f20<\/a>\u00a0\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u540e\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u663e\u7740\u51cf\u8f7b\uff0c\u6897\u585e\u4f53\u79ef\u663e\u7740\u7f29\u5c0f\uff0c\u00a0<a class=\"topic-link\" title=\"\u901a\u8fc7 ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u795e\u7ecf\u529f\u80fd\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nervous-system-physiology\">\u795e\u7ecf\u529f\u80fd<\/a>\u00a0\u8bc4\u5206\u4e5f\u663e\u8457\u6539\u5584\u3002\u6291\u5236AIM2\u708e\u75c7\u5c0f\u4f53\u7684\u6fc0\u6d3b\u53ef\u4ee5\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u6291\u5236\u7ec6\u80de\u7126\u4ea1\u7684\u53d1\u751f\uff0c\u4ece\u800c\u51cf\u8f7b\u7f3a\u8840\u6027\u8111\u635f\u4f24\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib113\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib113\"><span class=\"anchor-text\">[113]<\/span><\/a>\u56e0\u6b64\uff0c\u7ec6\u80de\u7126\u4ea1\u5728\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u8fc7\u7a0b\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\uff0cNLRP3\u708e\u75c7\u5c0f\u4f53\u662f\u7ec6\u80de\u7126\u4ea1\u9014\u5f84\u4e2d\u7684\u5173\u952e\u86cb\u767d\uff0c\u6291\u5236\u5176\u8868\u8fbe\u53ef\u540c\u65f6\u6291\u5236\u4e0b\u6e38\u7ec6\u80de\u7126\u4ea1\u9014\u5f84\u76f8\u5173\u86cb\u767d\u7684\u8868\u8fbe\uff0c\u9650\u5236\u708e\u75c7\u53cd\u5e94\uff0c\u51cf\u8f7b\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u3002<\/p>\n<\/section>\n<section id=\"sec0055\">\n<h3 id=\"sect0075\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.6\u3002 IS\u540e\u7126\u4ea1\u548c\u7ebf\u7c92\u4f53\u635f\u4f24\u4ecb\u5bfc\u6c27\u5316\u5e94\u6fc0\u635f\u4f24<\/h3>\n<p id=\"p0095\">\u7ebf\u7c92\u4f53\u4e3b\u8981\u53c2\u4e0e\u7ec6\u80de\u7684\u6709\u6c27\u547c\u5438\uff0c\u662f\u6709\u6c27\u547c\u5438\u53d1\u751f\u7684\u573a\u6240\u3002\u7ebf\u7c92\u4f53\u4e3a\u7ec6\u80de\u95f4\u7684\u6b63\u5e38\u4fe1\u53f7\u4f20\u9012\u548c\u795e\u7ecf\u7ec6\u80de\u7684\u4fe1\u53f7\u8f6c\u5bfc\u63d0\u4f9b\u4e86\u7535\u79bb\u57fa\u7840\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib114\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib114\"><span class=\"anchor-text\">[114]<\/span><\/a>\u3002\u7ebf\u7c92\u4f53\u635f\u4f24\u5927\u591a\u662f\u7531\u5f02\u5e38\u5f15\u8d77\u7684\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7ebf\u7c92\u4f53\u4ee3\u8c22\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitochondrial-respiration\">\u7ebf\u7c92\u4f53\u4ee3\u8c22<\/a>\u00a0\u548c\u6c27\u5316\u635f\u4f24\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib115\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib115\"><span class=\"anchor-text\">[115]<\/span><\/a>\u7814\u7a76\u8868\u660e\uff0c\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u4e0e\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u5bc6\u5207\u76f8\u5173\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib116\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib116\"><span class=\"anchor-text\">[116]<\/span><\/a>\u6c27\u5316\u5e94\u6fc0\u4f5c\u4e3a\u6c27\u5316\u635f\u4f24\u53d1\u751f\u7684\u5173\u952e\uff0c\u4e0e\u7ec6\u80de\u7126\u4ea1\u5bc6\u5207\u76f8\u5173\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib117\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib117\"><span class=\"anchor-text\">[117]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib118\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib118\"><span class=\"anchor-text\">[118]<\/span><\/a>\u6c27\u5316\u5e94\u6fc0\u66f4\u53ef\u80fd\u8868\u73b0\u5728\u8111\u7ec4\u7ec7\u635f\u4f24\u4e2d\uff0c\u5c24\u5176\u662f\u5728\u8111\u7f3a\u8840\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u518d\u704c\u6ce8\u635f\u4f24\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/reperfusion-injury\">\u518d\u704c\u6ce8\u635f\u4f24<\/a>\u00a0\u8111\u7f3a\u8840\u540e\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib119\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib119\"><span class=\"anchor-text\">[119]<\/span><\/a>\u3002\u5f53\u8eab\u4f53\u53d7\u5230\u5916\u754c\u6709\u5bb3\u7269\u8d28\u7684\u653b\u51fb\u65f6\uff0c\u7ec6\u80de\u4f1a\u5206\u6ccc\u5927\u91cf\u7684\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 ROS \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/reactive-oxygen-species\">\u6d3b\u6027\u6c27<\/a>\u00a0\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6d3b\u6027\u70ad\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/activated-charcoal\">\u6d3b\u6027\u70ad<\/a>\uff0c\u7834\u574f\u4e86\u6c27\u5316\u4e0e\u6297\u6c27\u5316\u7684\u5e73\u8861\uff0c\u5bfc\u81f4\u4e00\u7cfb\u5217\u6c27\u5316\u635f\u4f24\u53cd\u5e94\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib120\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib120\"><span class=\"anchor-text\">[120]<\/span><\/a>\u3002\u5927\u90e8\u5206ROS\u662f\u7531\u7ebf\u7c92\u4f53\u5206\u6ccc\u7684\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib121\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib121\"><span class=\"anchor-text\">[121]<\/span><\/a>\u5f53\u673a\u4f53\u53d7\u5230\u5916\u754c\u523a\u6fc0\u6216\u53d1\u751f\u5185\u6e90\u6027\u635f\u4f24\u65f6\uff0c\u673a\u4f53\u901a\u8fc7\u8bf1\u5bfc\u9ad8\u6c34\u5e73\u7684ROS\u523a\u6fc0\u6838\u82f7\u9178\u4e0eNLRP3\u7ed3\u5408\uff0c\u6fc0\u6d3b\u708e\u75c7\u5c0f\u4f53\u86cb\u767d\u590d\u5408\u7269\u3002\u5f53ROS\u8fc7\u5ea6\u6fc0\u6d3b\u65f6\uff0c\u673a\u4f53\u4fe1\u53f7\u901a\u8def\u7684\u6b63\u5e38\u987a\u5e8f\u88ab\u6253\u4e71\uff0c\u5bfc\u81f4\u9057\u4f20\u7269\u8d28\u3001\u86cb\u767d\u8d28\u4ee5\u53ca\u7ec6\u80de\u5185\u5404\u79cd\u7ec6\u80de\u5668\uff08\u5305\u62ec\u7ebf\u7c92\u4f53\uff09\u7684\u7834\u574f\u3002\u5f53\u7ec6\u80de\u5185\u7ebf\u7c92\u4f53\u7b49\u5404\u79cd\u7ec6\u80de\u5668\u53d7\u635f\u65f6\uff0c\u7ec6\u80de\u8425\u517b\u4ee3\u8c22\u5f02\u5e38\uff0cROS\u53ef\u8fdb\u4e00\u6b65\u52a0\u91cd\u7ec6\u80de\u7684\u635f\u4f24\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8840\u7ba1\u5185\u76ae\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascular-endothelium\">\u8840\u7ba1\u5185\u76ae<\/a>\u00a0\u5e76\u5f15\u8d77\u5e72\u6270\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5fae\u5faa\u73af\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microcirculation\">\u5fae\u5faa\u73af<\/a>\u00a0\u5728\u5927\u8111\u4e2d\u3002\u5927\u8111\u8840\u8111\u5c4f\u969c\u901a\u900f\u6027\u969c\u788d\u5bfc\u81f4\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7ec6\u80de\u7c98\u9644\u5206\u5b50\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-adhesion-molecule\">\u7ec6\u80de\u7c98\u9644\u5206\u5b50<\/a>\uff0c\u4ece\u800c\u52a0\u91cd\u8111\u635f\u4f24\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib122\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib122\"><span class=\"anchor-text\">[122]<\/span><\/a>\u3002 \u540c\u65f6\uff0c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6c27\u5316\u5e94\u6fc0\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/oxidative-stress\">\u6c27\u5316\u5e94\u6fc0<\/a>\u00a0\u5bfc\u81f4\u7ec6\u80de\u9010\u6e10\u8868\u73b0\u51fa\u7ec6\u80de\u6b7b\u4ea1\u6a21\u5f0f\uff0c\u5176\u7279\u5f81\u662f\u589e\u52a0\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7ec6\u80de\u819c\u6e17\u900f\u6027\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-membrane-permeability\">\u7ec6\u80de\u819c\u901a\u900f\u6027<\/a>\u00a0\u4ee5\u53ca\u7ec6\u80de\u5185\u5bb9\u7269\u7684\u91ca\u653e\u2014\u2014\u7ec6\u80de\u7126\u4ea1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib120\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib120\"><span class=\"anchor-text\">[120]<\/span><\/a>\u56e0\u6b64\uff0c\u7ec6\u80de\u7126\u4ea1\u548c\u7ebf\u7c92\u4f53\u635f\u4f24\u5747\u53c2\u4e0e\u4e86\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u7684\u75c5\u7406\u8fc7\u7a0b\u3002\u6709\u62a5\u9053\u6307\u51fa\uff0c\u7ebf\u7c92\u4f53\u8fd0\u52a8\u76f8\u5173\u86cb\u767dDrp1\u662f\u7ebf\u7c92\u4f53\u7ef4\u6301\u6b63\u5e38\u751f\u7406\u529f\u80fd\u6240\u5fc5\u9700\u7684\u5173\u952e\u86cb\u767d\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib123\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib123\"><span class=\"anchor-text\">[123]<\/span><\/a>\u3002\u5f53 Drp1 \u8868\u8fbe\u589e\u52a0\u65f6\uff0c\u53ef\u4ee5\u6291\u5236\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7ebf\u7c92\u4f53\u88c2\u53d8\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitochondrial-fission\">\u7ebf\u7c92\u4f53\u88c2\u53d8<\/a>\u00a0\u8fc7\u7a0b\uff0c\u964d\u4f4e\u7ec6\u80de\u7126\u4ea1\u7684\u7a0b\u5ea6\uff0c\u4ece\u800c\u51cf\u7f13\u635f\u4f24\u7684\u53d1\u751f\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib124\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib124\"><span class=\"anchor-text\">[124]<\/span><\/a>\u3002\u5f53\u673a\u4f53\u53d7\u5230\u591a\u79cd\u5185\u6e90\u6027\u548c\u5916\u6e90\u6027\u635f\u4f24\u523a\u6fc0\u65f6\uff0c\u4f53\u5185\u4fe1\u53f7\u901a\u8def\u7684\u8c03\u8282\u8fc7\u7a0b\u4f1a\u53d1\u751f\u53d8\u5316\u3002\u8868\u73b0\u4e3aDrp1\u5206\u6ccc\u51cf\u5c11\u3001\u7ebf\u7c92\u4f53\u635f\u4f24\u3001\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u4ee5\u53ca\u7ec6\u80de\u51cb\u4ea1\u548c\u7126\u4ea1\u589e\u591a\uff0c\u5bfc\u81f4\u4f53\u5185\u591a\u79cd\u75be\u75c5\u7684\u53d1\u751f\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib125\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib125\"><span class=\"anchor-text\">[125]<\/span><\/a>\u3002\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0c\u8111\u7f3a\u8840\/\u518d\u704c\u6ce8\u635f\u4f24\u671f\u95f4\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u4f1a\u8bf1\u5bfc NLRP3 \u708e\u75c7\u5c0f\u4f53\u6fc0\u6d3b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib126\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib126\"><span class=\"anchor-text\">[126]<\/span><\/a>. \u7ebf\u7c92\u4f53\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u89e3\u5076\u8054\u86cb\u767d\u8d28 2 \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/uncoupling-protein-2\">\u89e3\u5076\u8054\u86cb\u767d2<\/a>\u00a0(UCP2) \u7f3a\u4e4f\u4f1a\u52a0\u5267 CIRI \u540e\u7684\u8111\u635f\u4f24\uff0c\u65b0\u7814\u7a76\u8868\u660e\uff0cUCP2 \u7f3a\u4e4f\u4f1a\u5728\u4f53\u5185\u548c\u4f53\u5916\u9ad8\u8840\u7cd6\u8bf1\u53d1\u7684 CIRI \u52a0\u91cd\u540e\u589e\u5f3a NLRP3 \u708e\u75c7\u5c0f\u4f53\u6d3b\u5316\u3002UCP2 \u53ef\u80fd\u662f\u9ad8\u8840\u7cd6\u8bf1\u53d1\u7684 CIRI \u6076\u5316\u7684\u6f5c\u5728\u6cbb\u7597\u9776\u70b9\u3002UCP2 \u7f3a\u4e4f\u8fd8\u4f1a\u5728\u4f53\u5185\u548c\u4f53\u5916\u589e\u5f3a\u795e\u7ecf\u5143\u4e2d\u7684 NLRP3 \u708e\u75c7\u5c0f\u4f53\u6d3b\u5316\u548c ROS \u751f\u6210\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib127\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib127\"><span class=\"anchor-text\">[127]<\/span><\/a>.\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8102\u8054\u7d20\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/adiponectin\">\u8102\u8054\u7d20<\/a>\u00a0\u662f\u4e00\u79cd\u8102\u80aa\u6e90\u6027\u6fc0\u7d20\uff0c\u5177\u6709\u5e7f\u6cdb\u7684\u6297\u6c27\u5316\u548c\u6297\u708e\u4f5c\u7528\u3002\u8102\u8054\u7d20\u80bd\u901a\u8fc7\u8c03\u8282 AMPK\/GSK-3\u03b2 \u51cf\u8f7b\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u540e\u7684\u6c27\u5316\u5e94\u6fc0\u548c NLRP3 \u708e\u75c7\u5c0f\u4f53\u6fc0\u6d3b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib128\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib128\"><span class=\"anchor-text\">[128]<\/span><\/a>\u3002\u56e0\u6b64\uff0c\u5728IS\u4e2d\uff0c\u7ec6\u80de\u7126\u4ea1\u7684\u53d1\u751f\u4e0e\u7ebf\u7c92\u4f53\u635f\u4f24\u6709\u7740\u5bc6\u5207\u7684\u5173\u7cfb\uff0c\u5e76\u4e14\u4e24\u8005\u4e4b\u95f4\u5b58\u5728\u5bc6\u5207\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n<\/section>\n<section id=\"sec0060\">\n<h3 id=\"sect0080\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">2.7. \u6c27\u5316\u5e94\u6fc0\/\u4e9a\u785d\u5316\u5e94\u6fc0\u4ecb\u5bfcIS\u540e\u7684\u7ec6\u80de\u7126\u4ea1<\/h3>\n<p id=\"p0100\">\u6c27\u5316\/\u4e9a\u785d\u5316\u5e94\u6fc0\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u795e\u7ecf\u708e\u75c7\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroinflammation\">\u795e\u7ecf\u708e\u75c7<\/a>\u00a0\u662f\u5173\u952e\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u75c5\u7406\u8fc7\u7a0b\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathological-process\">\u75c5\u7406\u8fc7\u7a0b<\/a>\u00a0\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\uff0c\u4ecb\u5bfc\u7f3a\u8840\u6027\u4e2d\u98ce\u671f\u95f4\u7684\u795e\u7ecf\u5143\u635f\u4f24\u3001\u8840\u8111\u5c4f\u969c\u635f\u4f24\u548c\u51fa\u8840\u6027\u8f6c\u5316\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib129\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib129\"><span class=\"anchor-text\">[129]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib130\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib130\"><span class=\"anchor-text\">[130]<\/span><\/a>\u3002\u4e00\u6c27\u5316\u6c2e (NO) \u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8fc7\u6c27\u4e9a\u785d\u9178\u76d0\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/peroxynitrite\">\u8fc7\u6c27\u4e9a\u785d\u9178\u76d0<\/a>\u00a0(ONOO-)\u662fCIRI\u4e2d\u5178\u578b\u7684RNS\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib130\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib130\"><span class=\"anchor-text\">[130]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib131\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib131\"><span class=\"anchor-text\">[131]<\/span><\/a>. \u6709 3 \u79cd\u5f02\u6784\u4f53\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u4e00\u6c27\u5316\u6c2e\u5408\u9176\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nitric-oxide-synthase\">\u4e00\u6c27\u5316\u6c2e\u5408\u9176<\/a>:\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5185\u76ae\u4e00\u6c27\u5316\u6c2e\u5408\u9176\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/endothelial-nitric-oxide-synthase\">\u5185\u76ae\u4e00\u6c27\u5316\u6c2e\u5408\u9176<\/a>\u00a0(eNOS)\u4ea7\u751f\u4f4e\u6d53\u5ea6NO\u5e76\u5177\u6709\u751f\u7406\u529f\u80fd\uff1b\u5c3d\u7ba1\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u795e\u7ecf\u5143\u4e00\u6c27\u5316\u6c2e\u5408\u9176\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuronal-nitric-oxide-synthase\">\u795e\u7ecf\u5143\u578b\u4e00\u6c27\u5316\u6c2e\u5408\u9176<\/a>\u00a0\uff08nNOS\uff09\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8bf1\u5bfc\u578b\u4e00\u6c27\u5316\u6c2e\u5408\u9176\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inducible-nitric-oxide-synthase\">\u8bf1\u5bfc\u578b\u4e00\u6c27\u5316\u6c2e\u5408\u9176<\/a>\u00a0(iNOS) \u4ea7\u751f\u9ad8\u6d53\u5ea6\u7684\u4e00\u6c27\u5316\u6c2e\uff0c\u4ece\u800c\u8bf1\u53d1\u708e\u75c7\u5e76\u589e\u52a0\u8840\u8111\u5c4f\u969c\u7684\u901a\u900f\u6027\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib132\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib132\"><span class=\"anchor-text\">[132]<\/span><\/a>. ROS\/RNS \u7684\u8fc7\u91cf\u4ea7\u751f\u4f1a\u5f62\u6210\u538b\u529b\u6027\u5fae\u73af\u5883\uff0c\u5e76\u5f15\u53d1\u4e00\u7cfb\u5217\u7ec6\u80de\u4fe1\u53f7\u7ea7\u8054\u53cd\u5e94\uff0c\u4ece\u800c\u5bfc\u81f4\u708e\u75c7\u3001\u8840\u8111\u5c4f\u969c\u901a\u900f\u6027\u8fc7\u9ad8\u3001\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8111\u6c34\u80bf\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-edema\">\u8111\u6c34\u80bf<\/a>\u00a0\u4ee5\u53ca\u795e\u7ecf\u7ec6\u80de\u6b7b\u4ea1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib133\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib133\"><span class=\"anchor-text\">[133]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib134\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib134\"><span class=\"anchor-text\">[134]<\/span><\/a>. \u8fc7\u6c27\u4e9a\u785d\u9178\u76d0\u4ecb\u5bfc\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 DNA \u94fe\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/dna-strand\">DNA\u94fe<\/a>\u00a0\u6253\u7834\u5e76\u6fc0\u6d3b\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6838\u9176\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ribozyme\">\u6838\u9176<\/a>\u00a0\u805a\uff08ADP-\u6838\u7cd6\uff09\u5408\u9176\uff08PARS\uff09\uff0c\u4e5f\u79f0\u4e3a\u805a\uff08ADP-\u6838\u7cd6\uff09\u805a\u5408\u9176\uff08PARP\uff09\u6216\u805a\uff08ADP\u6838\u7cd6\uff09\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8f6c\u79fb\u9176\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/transferase\">\u8f6c\u79fb\u9176<\/a>\u00a0(pADPRT)\u3002ONOO-\u53ef\u4ee5\u76f4\u63a5\u6fc0\u6d3bPARP\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib135\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib135\"><span class=\"anchor-text\">[135]<\/span><\/a>\uff0c\u4f53\u5185\u5916\u5b9e\u9a8c\u8bc1\u660e\u4e86ONOO-\/PARP\u4fe1\u53f7\u901a\u8def\u5728\u7f3a\u8840\u6027\u8111\u635f\u4f24\u4e2d\u7684\u4f5c\u7528\u3002\u4f53\u5185\u5b9e\u9a8c\u8868\u660e\uff0cNOS \u7f3a\u9677\u5c0f\u9f20\u5728\u7f3a\u8840\u6027\u4e2d\u98ce\u52a8\u7269\u6a21\u578b\u4e2d\u663e\u793a\u51fa\u8f83\u5c11\u7684 PARP \u6fc0\u6d3b\u3002\u4f53\u5916\u5b9e\u9a8c\u8868\u660e\uff0cONOO \u4f9b\u4f53\u800c\u975e NO \u4f9b\u4f53\u5728\u57f9\u517b\u7684 C6 \u4e2d\u663e\u7740\u8bf1\u5bfc PARP \u6fc0\u6d3b\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u795e\u7ecf\u80f6\u8d28\u7624\u7ec6\u80de\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glioma-cell\">\u795e\u7ecf\u80f6\u8d28\u7624\u7ec6\u80de<\/a>.\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u57fa\u56e0\u7834\u574f\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/gene-disruption\">\u57fa\u56e0\u7834\u574f<\/a>\u00a0\u6216\u6c89\u9ed8PARP\u53ef\u663e\u8457\u964d\u4f4e\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8111\u6897\u585e\u5927\u5c0f\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-infarction-size\">\u8111\u6897\u585e\u9762\u79ef<\/a>\uff0c\u7f13\u89e3\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u795e\u7ecf\u6bd2\u6027\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neurotoxicity\">\u795e\u7ecf\u6bd2\u6027<\/a>\uff0c\u4fdd\u62a4\u795e\u7ecf\u8840\u7ba1\u5355\u4f4d\u5e76\u6539\u5584\u795e\u7ecf\u7cfb\u7edf\u7ed3\u679c\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib136\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib136\"><span class=\"anchor-text\">[136]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib137\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib137\"><span class=\"anchor-text\">[137]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib138\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib138\"><span class=\"anchor-text\">[138]<\/span><\/a>\u3002\u7814\u7a76\u53d1\u73b0ROS\/RNS\u53ef\u80fd\u662fCIRI\u8fc7\u7a0b\u4e2d\u708e\u75c7\u5c0f\u4f53\u7684\u6fc0\u6d3b\u5242\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib139\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib139\"><span class=\"anchor-text\">[139]<\/span><\/a>\u708e\u75c7\u5c0f\u4f53\u662f\u5c0f\u80f6\u8d28\u7ec6\u80de\u80de\u6d46\u4e2d\u7684\u591a\u86cb\u767d\u590d\u5408\u7269\uff0c\u5176\u4e2dNOD\u6837\u53d7\u4f533\uff08NLRP3\uff09\u662f\u7814\u7a76\u6700\u5e7f\u6cdb\u7684\u4e00\u79cd\u3002NLRP3\u89e6\u53d1\u5e76\u6fc0\u6d3bcaspase-1\uff0c\u6fc0\u6d3bIL-1\u03b2\u548cIL-18\u5e76\u5c06\u5b83\u4eec\u91ca\u653e\u5230\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7ec6\u80de\u5916\u7a7a\u95f4\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/extracellular-space\">\u7ec6\u80de\u5916\u7a7a\u95f4<\/a>\uff0c\u4fc3\u8fdb\u708e\u75c7\u7684\u53d1\u5c55\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib140\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib140\"><span class=\"anchor-text\">[140]<\/span><\/a>\u3002\u4f53\u5185\u5b9e\u9a8c\u8868\u660e\uff0cNLPR3\u6572\u9664\u5c0f\u9f20\u7684\u8111\u6897\u585e\u9762\u79ef\u548c\u8840\u8111\u5c4f\u969c\u635f\u4f24\u5747\u4f4e\u4e8e\u91ce\u751f\u578b\u5c0f\u9f20\u3002\u8fdb\u4e00\u6b65\u5b9e\u9a8c\u8868\u660eNLRP3\u53ef\u4ee5\u4ecb\u5bfcIL-1\u03b2\u7684\u91ca\u653e\u5e76\u589e\u52a0\u8111\u5fae\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u901a\u900f\u6027\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib141\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib141\"><span class=\"anchor-text\">[141]<\/span><\/a>. \u6838\u56e0\u5b50 E2 \u76f8\u5173\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u56e0\u5b50 2 \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/prothrombin\">\u56e0\u7d20 2<\/a>\u00a0(Nrf2) \u8c03\u8282\u7ec6\u80de\u6297\u6c27\u5316\u53cd\u5e94\uff0c\u5728\u6c27\u6c14\u548c\u8461\u8404\u7cd6\u5265\u593a\u6761\u4ef6\u4e0b\uff0cNrf2 \u6291\u5236 BV2 \u5c0f\u80f6\u8d28\u7ec6\u80de\u4e2d ROS \u4ecb\u5bfc\u7684 NLRP3 \u4ea7\u751f\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib142\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib142\"><span class=\"anchor-text\">[142]<\/span><\/a>\u3002\u7814\u7a76\u53d1\u73b0\u6c27\u5316\/\u4e9a\u785d\u5316\u5e94\u6fc0\u8bf1\u5bfc\u8fc7\u6c27\u4e9a\u785d\u9178\u76d0\u7684\u5f62\u6210\uff0c\u8fd9\u53ef\u80fd\u662f caspase1\/\u708e\u75c7\u5c0f\u4f53\u6fc0\u6d3b\u7684\u5173\u952e\u89e6\u53d1\u56e0\u7d20\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib143\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib143\"><span class=\"anchor-text\">[143]<\/span><\/a>\u3002\u56e0\u6b64\uff0cROS\/RNS\u4ecb\u5bfc\u7684\u708e\u75c7\u5c0f\u4f53\u53ef\u80fd\u662f\u7f3a\u8840\u6027\u8111\u635f\u4f24\u7684\u6f5c\u5728\u6cbb\u7597\u9776\u70b9\u3002<\/p>\n<p id=\"p0105\">\u6b64\u5916\uff0cROS\/RNS \u4ecb\u5bfc Toll \u6837\u53d7\u4f53\u7684\u6fc0\u6d3b\u3002\u76ee\u524d\u7684\u7814\u7a76\u8868\u660e\uff0cToll \u6837\u53d7\u4f53 (TLR) \u4f5c\u4e3a\u4e00\u79cd\u5148\u5929\u6027\u53d7\u4f53\u5df2\u88ab\u5e7f\u6cdb\u7814\u7a76\u3002\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u514d\u75ab\u53d7\u4f53\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immune-system-receptors\">\u514d\u75ab\u53d7\u4f53<\/a>\u548cTLR4\/2\u5728\u8111\u4e2d\u5f97\u5230\u66f4\u591a\u7814\u7a76\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7f3a\u8840\u6027\u635f\u4f24\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemic-injury\">\u7f3a\u8840\u6027\u635f\u4f24<\/a>.\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 TLR4 \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/toll-like-receptor-4\">TLR4<\/a>\u00a0\u53ef\u4ecb\u5bfcIL-1\u03b2\u3001MMP-9\u3001iNOS\u3001COX-2\u7684\u8868\u8fbe\uff0c\u52a0\u91cd\u6c27\u5316\u5e94\u6fc0\u5f15\u8d77\u7684\u8111\u635f\u4f24\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib144\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib144\"><span class=\"anchor-text\">[144]<\/span><\/a>\u3002 TLR4\u6291\u5236\u5242\u7684\u5e94\u7528\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 E5564 \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/eritoran\">E5564<\/a>\u00a0\u8868\u660e\u5b83\u53ef\u4ee5\u53d1\u6325\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u795e\u7ecf\u4fdd\u62a4\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroprotective-agent\">\u795e\u7ecf\u4fdd\u62a4<\/a>\u00a0\u901a\u8fc7\u6291\u5236\u5c0f\u80f6\u8d28\u7ec6\u80de\u7684\u6fc0\u6d3b\u548cROS\u7684\u4ea7\u751f\u6765\u53d1\u6325\u4f5c\u7528\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib145\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib145\"><span class=\"anchor-text\">[145]<\/span><\/a>\u3002 IS\u540e\uff0cTLR4\u7f3a\u9677\u5c0f\u9f20\u7684\u6897\u6b7b\u9762\u79ef\u660e\u663e\u5c0f\u4e8e\u91ce\u751f\u578b\u5c0f\u9f20\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib146\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib146\"><span class=\"anchor-text\">[146]<\/span><\/a>\u3002 TLR4\u4e5f\u53c2\u4e0e\u540eIS\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u795e\u7ecf\u53d1\u751f\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neurogenesis\">\u795e\u7ecf\u53d1\u751f<\/a>.\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6b63\u7535\u5b50\u53d1\u5c04\u65ad\u5c42\u626b\u63cf\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/positron-emission-tomography\">\u6b63\u7535\u5b50\u53d1\u5c04\u65ad\u5c42\u626b\u63cf<\/a>\u00a0\u7814\u7a76\u8868\u660e\uff0cTLR4 \u7f3a\u9677\u5c0f\u9f20\u7684 IS \u795e\u7ecf\u53d1\u751f\u589e\u5f3a\u5e76\u6291\u5236\u708e\u75c7\u53cd\u5e94\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib147\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib147\"><span class=\"anchor-text\">[147]<\/span><\/a>\u6b64\u5916\uff0c\u5728\u4f53\u5b9e\u9a8c\u7814\u7a76\u8868\u660e\uff0c\u6291\u5236TLR2\/4\/NF-\u03baB\u4fe1\u53f7\u901a\u8def\u5bf9\u8c03\u8282\u6c27\u5316\u5e94\u6fc0\u3001\u708e\u75c7\u53cd\u5e94\u3001\u4fdd\u62a4\u7f3a\u8840\u8111\u7ec4\u7ec7\u5177\u6709\u4e00\u5b9a\u4f5c\u7528\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib148\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib148\"><span class=\"anchor-text\">[148]<\/span><\/a>.\u56e0\u6b64\uff0cTLR4\/2\u53ef\u80fd\u6210\u4e3a\u7f3a\u8840\u6027\u8111\u635f\u4f24\u7684\u6cbb\u7597\u9776\u70b9\u3002<\/p>\n<\/section>\n<\/section>\n<section id=\"sec0065\">\n<h2 id=\"sect0085\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">3.\u7ec6\u80de\u7126\u4ea1\u4e0eIS\u7684\u5173\u7cfb<\/h2>\n<p id=\"p0110\">\u8111\u75c5\u7684\u75c5\u7406\u673a\u5236\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7f3a\u8840\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemia\">\u7f3a\u8840<\/a>\u00a0\u7f3a\u8840\u518d\u704c\u6ce8\u540e\u635f\u4f24\u662f\u590d\u6742\u7684\u3002\u8be5\u8fc7\u7a0b\u6d89\u53ca\u7684\u673a\u5236\u5305\u62ec\u708e\u75c7\u3001\u6c27\u5316\u5e94\u6fc0\u3001\u81ea\u566c\u3001\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u3001\u9499\u8d85\u8f7d\u548c\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib149\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib149\"><span class=\"anchor-text\">[149]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib150\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib150\"><span class=\"anchor-text\">[150]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib151\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib151\"><span class=\"anchor-text\">[151]<\/span><\/a>\u3002\u591a\u9879\u7814\u7a76\u8868\u660e\uff0c\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u5728\u8111\u7f3a\u8840\u53ca\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u7684\u75c5\u7406\u8fc7\u7a0b\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u5e76\u4e0e\u4e0a\u8ff0\u673a\u5236\u5c24\u5176\u662f\u7ec6\u80de\u7126\u4ea1\u76f8\u4e92\u4ea4\u7ec7\u3001\u5bc6\u5207\u76f8\u5173\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib152\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib152\"><span class=\"anchor-text\">[152]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib153\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib153\"><span class=\"anchor-text\">[153]<\/span><\/a>\u3002\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u662f\u7f3a\u8840\u6027\u4e2d\u98ce\u7684\u4e3b\u8981\u4e8b\u4ef6\uff0c\u6d89\u53ca\u795e\u7ecf\u5143\u3001\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5c0f\u80f6\u8d28\u7ec6\u80de\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microglia\">\u5c0f\u80f6\u8d28\u7ec6\u80de<\/a>, \u661f\u5f62\u80f6\u8d28\u7ec6\u80de,\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascular-endothelial-cell\">\u8840\u7ba1\u5185\u76ae\u7ec6\u80de<\/a>\u7b49\u7b49\uff0c\u6bd4\u5982\u7ec6\u80de\u51cb\u4ea1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib154\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib154\"><span class=\"anchor-text\">[154]<\/span><\/a>\u3001\u81ea\u566c\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib155\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib155\"><span class=\"anchor-text\">[155]<\/span><\/a>, \u7a0b\u5e8f\u6027\u574f\u6b7b\u6216\u574f\u6b7b\u6027\u51cb\u4ea1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib156\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib156\"><span class=\"anchor-text\">[156]<\/span><\/a>,\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u94c1\u6b7b\u4ea1\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ferroptosis\">\u94c1\u6b7b\u4ea1<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib157\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib157\"><span class=\"anchor-text\">[157]<\/span><\/a>\u4ee5\u53ca\u7ec6\u80de\u7126\u4ea1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib158\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib158\"><span class=\"anchor-text\">[158]<\/span><\/a>\u5c24\u5176\u662f\u5728\u7ec6\u80de\u7126\u4ea1\u4e2d\uff0c\u5927\u9f20\u8111\u7f3a\u8840\u6a21\u578b\u4e2d\uff0cNLRP1\u3001ASC\u3001Caspase-1\u3001GSDMD\u7b49\u7ec6\u80de\u7126\u4ea1\u76f8\u5173\u86cb\u767d\u8868\u8fbe\u589e\u591a\uff0c\u6291\u5236NLRP1\u53ef\u4ee5\u51cf\u8f7b\u708e\u75c7\u548c\u8111\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7f3a\u8840\u6027\u635f\u4f24\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ischemic-injury\">\u7f3a\u8840\u6027\u635f\u4f24<\/a>\u3002\u6b64\u5916\uff0c\u5728\u6162\u6027\u8111\u7f3a\u8840\u7684\u60c5\u51b5\u4e0b\uff0c\u7ec6\u80de\u901a\u8fc7\u91ca\u653eDAMPs\u548cDAMPs\u7b49\u4fe1\u53f7\u6765\u4fc3\u8fdb\u708e\u75c7\u53cd\u5e94\u3002\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 PAMP \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathogen-associated-molecular-pattern\">\u78f7\u9178\u817a\u82f7<\/a>\uff0c\u5e76\u5f15\u53d1\u4e00\u7cfb\u5217\u590d\u6742\u7684\u5206\u5b50\u53cd\u5e94\u3002\u6b64\u65f6\uff0c\u9885\u5185\u795e\u7ecf\u514d\u75ab\u708e\u75c7\u7ec6\u80de\uff0c\u5982\u5c0f\u80f6\u8d28\u7ec6\u80de\u548c\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u51fa\u73b0\u589e\u6b96\u548c\u6fc0\u6d3b\uff0c\u8fdb\u4e00\u6b65\u635f\u5bb3\u795e\u7ecf\u8840\u7ba1\u5355\u5143\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib159\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib159\"><span class=\"anchor-text\">[159]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib160\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib160\"><span class=\"anchor-text\">[160]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib161\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib161\"><span class=\"anchor-text\">[161]<\/span><\/a>.<\/p>\n<section id=\"sec0070\">\n<h3 id=\"sect0090\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">3.1. \u7ec6\u80de\u7126\u4ea1\u548c\u795e\u7ecf\u5143<\/h3>\n<p id=\"p0115\">\u7f3a\u8840\u540e\uff0c\u4e2d\u5fc3\u7f3a\u8840\u533a\u57df\u77ed\u65f6\u95f4\u5185\u53d1\u751f\u574f\u6b7b\uff0c\u6b7b\u4ea1\u7ec6\u80de\u91ca\u653e\u5371\u9669\u4fe1\u53f7\uff0c\u5982\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 HMGB1 \u86cb\u767d\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/high-mobility-group-b1-protein\">HMGB1\u86cb\u767d<\/a>,\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u70ed\u4f11\u514b\u86cb\u767d\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/heat-shock-protein\">\u70ed\u4f11\u514b\u86cb\u767d<\/a>,\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8fc7\u6c27\u5316\u7269\u9176\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/peroxidase\">\u8fc7\u6c27\u5316\u7269\u9176<\/a>\u00a0\u5bb6\u65cf\u86cb\u767d\u7b49\u3002\u8fd9\u4e9b\u5371\u9669\u4fe1\u53f7\u5206\u5b50\u4e0e\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pattern-recognition-receptor\">\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53<\/a>\uff0c \u5f62\u5f0f\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u708e\u75c7\u5c0f\u4f53\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammasome\">\u708e\u75c7\u5c0f\u4f53<\/a>\u542f\u52a8\u5148\u5929\u514d\u75ab\u53cd\u5e94\uff0c\u5e76\u5bfc\u81f4\u795e\u7ecf\u5143\u6b7b\u4ea1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib162\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib162\"><span class=\"anchor-text\">[162]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib163\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib163\"><span class=\"anchor-text\">[163]<\/span><\/a>\u7814\u7a76\u8bc1\u5b9e\uff0c\u8111\u7f3a\u8840\u53ef\u5bfc\u81f4NLRP1\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 NLRP3 \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nucleotide-binding-oligomerization-domain-like-receptor\">NLRP3<\/a>\u00a0\u5728\u7f3a\u8840\u8111\u7ec4\u7ec7\u548c\u795e\u7ecf\u5143\u4e2d\uff0cNLRP1\u7684\u6fc0\u6d3b\u4e3b\u8981\u5b58\u5728\u4e8e\u795e\u7ecf\u5143\u4e2d\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib164\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib164\"><span class=\"anchor-text\">[164]<\/span><\/a>\u3002\u4f7f\u7528Caspase-1\u6291\u5236\u5242\u6216\u514d\u75ab\u7403\u86cb\u767d\u5236\u5242\u53ef\u4ee5\u51cf\u5f31\u539f\u4ee3\u76ae\u8d28\u795e\u7ecf\u5143\u4e2dNLRP1\u548cNLRP3\u7684\u8868\u8fbe\uff0c\u5e76\u51cf\u5c11\u795e\u7ecf\u5143\u7684\u5927\u5c0f\u3002\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8111\u6897\u585e\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-infarction\">\u8111\u6897\u585e<\/a>,\u5176\u673a\u5236\u53ef\u80fd\u4e0e\u6291\u5236NF-\u03baB\u53caMAPK\u901a\u8def\u6fc0\u6d3b\u6709\u5173\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib164\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib164\"><span class=\"anchor-text\">[164]<\/span><\/a>\u3002\u5728 IS \u5c0f\u9f20\u4e2d\uff0cLi \u7b49\u4eba\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib165\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib165\"><span class=\"anchor-text\">[165]<\/span><\/a>\u00a0\u53d1\u73b0\u8111\u7f3a\u8840\u7b2c3\u5929\uff0c\u795e\u7ecf\u5143\u80de\u6d46\u3001\u6838\u53ca\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7ebf\u7c92\u4f53\u819c\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitochondrial-membrane\">\u7ebf\u7c92\u4f53\u819c<\/a>\u00a0\u53d1\u751f\uff0cCaspase-1\u3001GSDMD \u548c IL-1\u03b2 \u7684\u8868\u8fbe\u663e\u8457\u589e\u52a0\u3002Caspase-1 \u6291\u5236\u5242\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 Vx765 \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/belnacasan\">Vx765<\/a>\u00a0\u80fd\u6291\u5236\u7ec6\u80de\u7126\u4ea1\uff0c\u4fc3\u8fdb\u7f3a\u8840\u533a\u57df\u795e\u7ecf\u5143\u5b58\u6d3b\uff0c\u6539\u5584\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5927\u8111\u529f\u80fd\u969c\u788d\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-dysfunction\">\u8111\u529f\u80fd\u969c\u788d<\/a>\u00a0\u5728\u5c0f\u9f20\u4e2d\u3002Liang \u7b49\u4eba\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib166\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib166\"><span class=\"anchor-text\">[166]<\/span><\/a>\u00a0\u53d1\u73b0\u957f\u975e\u7f16\u7801RNA\u6bcd\u6e90\u8868\u8fbe\u57fa\u56e03\uff08MEG3\uff09\u901a\u8fc7\u6fc0\u6d3bAIM2\/Caspase-1\u901a\u8def\u4fc3\u8fdb\u7ec6\u80de\u7126\u4ea1\u548c\u708e\u75c7\u53cd\u5e94\uff0c\u5bfc\u81f4\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u3002 MEG3\u57fa\u56e0\u6572\u9664\u53ef\u6291\u5236MEG3\u57fa\u56e0\u7684\u8868\u8fbe\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 AIM2 \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nodular-melanoma\">\u76ee\u68072<\/a>\u3001Caspase-1\u3001GSDMD\u7b49\u86cb\u767d\uff0c\u51cf\u8f7b\u7f3a\u8840\u6027\u8111\u635f\u4f24\uff0c\u63d0\u793aMEG3\u53ef\u80fd\u662f\u7f3a\u8840\u6027\u8111\u5352\u4e2d\u7684\u6709\u6548\u6cbb\u7597\u9776\u70b9\u3002<\/p>\n<\/section>\n<section id=\"sec0075\">\n<h3 id=\"sect0095\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">3.2. \u7ec6\u80de\u7126\u4ea1\u548c\u661f\u5f62\u80f6\u8d28\u7ec6\u80de<\/h3>\n<p id=\"p0120\">\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u6570\u91cf\u6700\u591a\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u795e\u7ecf\u80f6\u8d28\u7ec6\u80de\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glial-cells\">\u795e\u7ecf\u80f6\u8d28\u7ec6\u80de<\/a>\u00a0\u5728\u91cc\u9762\u00a0<a class=\"topic-link\" title=\"\u901a\u8fc7 ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/central-nervous-system\">\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf<\/a>\u00a0\u53c2\u4e0e\u8840\u8111\u5c4f\u969c\u7684\u5f62\u6210\u3001\u8c03\u8282\u795e\u7ecf\u5143\u4ee3\u8c22\u548c\u7a33\u5b9a\u7ec6\u80de\u95f4\u901a\u8baf\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib167\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib167\"><span class=\"anchor-text\">[167]<\/span><\/a>\u3002 IS\u540e\uff0c\u663e\u7740\u7684\u75c5\u7406\u53d8\u5316\u662f\u53cd\u5e94\u6027\u7684\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u661f\u5f62\u80f6\u8d28\u589e\u751f\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/astrocytosis\">\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u589e\u751f<\/a>\u00a0\u548c\u795e\u7ecf\u80f6\u8d28\u75a4\u75d5\uff0c\u4fc3\u8fdb\u7f3a\u8840\u6027\u635f\u4f24\u540e\u65e9\u671f\u7684\u795e\u7ecf\u5143\u53ef\u5851\u6027\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib168\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib168\"><span class=\"anchor-text\">[168]<\/span><\/a>\u3002\u4eba\u4eec\u666e\u904d\u8ba4\u4e3a\uff0c\u5f53\u00a0<a class=\"topic-link\" title=\"\u901a\u8fc7 ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6d77\u9a6c\u4f53\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hippocampus\">\u6d77\u9a6c\u4f53<\/a>\u00a0\u662f\u7f3a\u8840\u5e76\u4e14\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7f3a\u6c27\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hypoxia\">\u7f3a\u6c27<\/a>\uff0c \u8fd9\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6297\u6c27\u5316\u80fd\u529b\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antioxidant-capacity\">\u6297\u6c27\u5316\u80fd\u529b<\/a>\u00a0\u6d77\u9a6c\u4f53\u7684\u529f\u80fd\u4f1a\u51cf\u5f31\uff0c\u5927\u91cf\u708e\u75c7\u56e0\u5b50\u53ef\u80fd\u88ab\u91ca\u653e\uff0c\u4ece\u800c\u52a0\u91cd\u6d77\u9a6c\u4f53\u7684\u635f\u4f24\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib169\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib169\"><span class=\"anchor-text\">[169]<\/span><\/a>\u3002\u5c40\u7076\u6027\u8111\u7f3a\u8840\u540e\u4e09\uff083\uff09\u5c0f\u65f6\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 SD \u5927\u9f20\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/sprague-dawley-rat\">SD\u5927\u9f20<\/a>\uff0c\u7f3a\u8840\u533a\u51fa\u73b0IL-1\u03b2\u6837\u514d\u75ab\u53cd\u5e94\u9633\u6027\u7ec6\u80de\uff0c\u4e3b\u8981\u662f\u706d\u6d3b\u7684\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u3002\u76f4\u81f3\u7f3a\u8840\u540e2\u4e2a\u6708\uff0c\u7f3a\u8840\u534a\u7403\u4ecd\u53ef\u68c0\u6d4b\u5230\u9633\u6027\u7ec6\u80de\uff0c\u5c24\u5176\u662f\u574f\u6b7b\u7076\u5468\u56f4\uff0c\u4e14\u6d3b\u5316\u7a0b\u5ea6\u8d8a\u9ad8\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib170\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib170\"><span class=\"anchor-text\">[170]<\/span><\/a>. \u6fc0\u6d3b\u7684\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u53ef\u4ee5\u8bf1\u5bfc\u91ca\u653e\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tumor-necrosis-factor\">\u80bf\u7624\u574f\u6b7b\u56e0\u5b50<\/a>\u3001\u767d\u7ec6\u80de\u4ecb\u7d20\u3001\u751f\u957f\u56e0\u5b50\u7b49\u708e\u75c7\u56e0\u5b50\u6216\u795e\u7ecf\u5143\u6bd2\u6027\u4ecb\u8d28\uff0c\u5bfc\u81f4\u795e\u7ecf\u5143\u635f\u4f24\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib171\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib171\"><span class=\"anchor-text\">[171]<\/span><\/a>NLRP2\u4e3b\u8981\u5728\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4e2d\u8868\u8fbe\uff0c\u5728\u795e\u7ecf\u5143\u548c\u5c0f\u80f6\u8d28\u7ec6\u80de\u4e2d\u51e0\u4e4e\u4e0d\u8868\u8fbe\u3002\u5c0f\u9f20\u8111\u7f3a\u8840\u6a21\u578b\u53ca\u7f3a\u6c27\u7f3a\u7cd6\u540e\uff0c\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4e2dNLRP2\u8868\u8fbe\u660e\u663e\u4e0a\u8c03\uff0c\u6c89\u9ed8NLRP2\u53ef\u51cf\u8f7b\u7f3a\u6c27\u7f3a\u7cd6\u8bf1\u5bfc\u7684\u7ec6\u80de\u7126\u4ea1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib172\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib172\"><span class=\"anchor-text\">[172]<\/span><\/a>\u53e6\u4e00\u9879\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u4f53\u5916\u8111\u7f3a\u8840\u6a21\u578b\u4e2d\uff0c\u6c27\u7cd6\u5265\u593a\u5bfc\u81f4NLRP3\u3001ASC\u3001Caspase-1\u3001IL-1\u03b2\u548cIL-18\u589e\u52a0\uff0c\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u5b58\u6d3b\u7387\u964d\u4f4e\u3002\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 Hispidulin \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hispidulin\">\u7ec4\u86cb\u767d<\/a>\u00a0\u662f\u4e00\u79cd\u916e\u5316\u5408\u7269\uff0c\u5206\u79bb\u81ea\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684\u4eba\u5de5\u667a\u80fd\u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u4e2d\u8349\u836f\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chinese-herbal-medicine\">\u4e2d\u8349\u836f<\/a>\u4f53\u5916\u548c\u4f53\u5185\u5b9e\u9a8c\u5747\u8868\u660e\uff0cHispidulin \u80fd\u591f\u6291\u5236 NLRP3 \u4ecb\u5bfc\u7684\u7ec6\u80de\u7126\u4ea1\uff0c\u53d1\u6325\u8111\u4fdd\u62a4\u4f5c\u7528\uff0c\u5176\u673a\u5236\u4e0e\u6fc0\u6d3b AMPK\/GSK-3\u03b2\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u4fe1\u53f7\u901a\u8def\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/signal-transduction\">\u4fe1\u53f7\u901a\u8def<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib173\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib173\"><span class=\"anchor-text\">[173]<\/span><\/a>\u3002\u5b5f\u7b49\u4eba\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib174\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib174\"><span class=\"anchor-text\">[174]<\/span><\/a>\u00a0\u7814\u7a76\u53d1\u73b0\u5927\u9f20\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u540eNLRP6\u8868\u8fbe\u572848h\u8fbe\u9ad8\u5cf0\uff0c\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u7f3a\u6c27\u7f3a\u7cd6\u540eNLRP6\u53ca\u5176\u6d3b\u5316\u4ea7\u7269\u751f\u6210\u589e\u591a\uff0c\u6c89\u9ed8NLRP6\u53ef\u964d\u4f4eASC\u53caCaspase-1\uff0c\u51cf\u5c11\u708e\u75c7\u56e0\u5b50\u91ca\u653e\uff0c\u589e\u52a0\u795e\u7ecf\u5143\u6d3b\u6027\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib175\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib175\"><span class=\"anchor-text\">[175]<\/span><\/a>\u56e0\u6b64\uff0c\u9488\u5bf9\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u708e\u75c7\u5c0f\u4f53\u6d3b\u5316\u7684\u5e72\u9884\u63aa\u65bd\u53ef\u80fd\u4e3aIS\u7684\u6cbb\u7597\u63d0\u4f9b\u65b0\u7684\u601d\u8def\u3002<\/p>\n<\/section>\n<section id=\"sec0080\">\n<h3 id=\"sect0100\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">3.3.\u7126\u4ea1\u548c\u5c0f\u80f6\u8d28\u7ec6\u80de<\/h3>\n<p id=\"p0125\">\u5c0f\u80f6\u8d28\u7ec6\u80de\u662f\u4e0e\u751f\u4ff1\u6765\u7684\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u514d\u75ab\u7ec6\u80de\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/immunocompetent-cell\">\u514d\u75ab\u7ec6\u80de<\/a>\u00a0\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u548c\u7f3a\u8840\u6027\u4e2d\u98ce\u540e\u6700\u65e9\u6fc0\u6d3b\u7684\u7ec6\u80de\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib176\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib176\"><span class=\"anchor-text\">[176]<\/span><\/a>\u5728\u8111\u7f3a\u8840\u635f\u4f24\u6025\u6027\u671f\uff0c\u5c0f\u80f6\u8d28\u7ec6\u80de\u5feb\u901f\u8fc1\u79fb\u81f3\u75c5\u7076\u90e8\u4f4d\u5e76\u5206\u6ccc\u708e\u75c7\u56e0\u5b50\u548c\u7ec6\u80de\u6bd2\u6027\u7269\u8d28\uff0c\u52a0\u91cd\u7ec4\u7ec7\u635f\u4f24\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib177\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib177\"><span class=\"anchor-text\">[177]<\/span><\/a>\u3002\u5728\u6162\u6027\u671f\uff0c\u5c0f\u80f6\u8d28\u7ec6\u80de\u53ef\u4ee5\u4ea7\u751f\u6297\u708e\u7ec6\u80de\u56e0\u5b50\u548c\u751f\u957f\u56e0\u5b50\uff0c\u4ee5\u4fc3\u8fdb\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7ec4\u7ec7\u4fee\u590d\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tissue-repair\">\u7ec4\u7ec7\u4fee\u590d<\/a>\u00a0\u548c\u6539\u9020\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib178\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib178\"><span class=\"anchor-text\">[178]<\/span><\/a>\u3002\u7814\u7a76\u53d1\u73b0\u5c0f\u80f6\u8d28\u7ec6\u80de\u7126\u4ea1\u5728\u7f3a\u8840\u6027\u8111\u635f\u4f24\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002\u5f53\u5c0f\u80f6\u8d28\u7ec6\u80de\u7f3a\u6c27\u548c\u7f3a\u7cd63\u5c0f\u65f6\u65f6\uff0cNLRC4\u662f\u7b2c\u4e00\u4e2a\u663e\u7740\u589e\u52a0\u7684\u708e\u75c7\u5c0f\u4f53\uff0c\u800cNLRP1\u3001NLRP3\u548cAIM2\u76f4\u5230\u7f3a\u6c27\u7f3a\u7cd66\u5c0f\u65f6\u540e\u624d\u663e\u7740\u589e\u52a0\u3002\u6c89\u9ed8NLRC4\u53ef\u51cf\u5c11GSDMD\u3001IL-1\u03b2\u548cIL-18\u7684\u4ea7\u751f\uff0c\u6291\u5236\u5c0f\u80f6\u8d28\u7ec6\u80de\u7126\u4ea1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib179\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib179\"><span class=\"anchor-text\">[179]<\/span><\/a>\u3002\u5f90\u7b49\u4eba\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib180\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib180\"><span class=\"anchor-text\">[180]<\/span><\/a>\u00a0\u62a5\u9053\u79f0\uff0c\u9a71\u52a8\u53d7\u4f53 1 (TREM-1) \u8868\u8fbe\u4e8e\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u9aa8\u9ad3\u7ec6\u80de\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/myeloid-cell\">\u9aa8\u9ad3\u7ec6\u80de<\/a>\u00a0\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u540e\u5c0f\u80f6\u8d28\u7ec6\u80de\u4e2dTREM-1\u7684\u8868\u8fbe\u53ef\u6fc0\u6d3bNLRP3\/Caspase-1\u4ecb\u5bfc\u7684\u7ec6\u80de\u7126\u4ea1\u901a\u8def\uff0c\u8bf1\u53d1\u795e\u7ecf\u708e\u75c7\u53cd\u5e94\u3002\u6291\u5236TREM-1\u53ef\u51cf\u8f7b\u5c0f\u80f6\u8d28\u7ec6\u80de\u7126\u4ea1\u548c\u795e\u7ecf\u635f\u4f24\u3002Li et al.\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib181\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib181\"><span class=\"anchor-text\">[181]<\/span><\/a>\u00a0\u8bc1\u5b9e\u8111\u7f3a\u8840\u540e\u73af\u78f7\u9178\u9e1f\u82f7-\u817a\u82f7\u5408\u9176\uff08cGAS\uff09\u7684\u8868\u8fbe\u4e0a\u8c03\u5e76\u6fc0\u6d3bAIM2\u708e\u75c7\u5c0f\u4f53\u8bf1\u5bfc\u5c0f\u80f6\u8d28\u7ec6\u80de\u7126\u4ea1\u3002 cGAS\u62ee\u6297\u5242A151\u53ef\u6291\u5236AIM2\u6fc0\u6d3b\u548c\u5c0f\u80f6\u8d28\u7ec6\u80de\u7126\u4ea1\uff0c\u663e\u7740\u51cf\u5c11\u8111\u6897\u585e\u4f53\u79ef\uff0c\u51cf\u8f7b\u795e\u7ecf\u635f\u4f24\u3002\u4e0a\u8ff0\u7814\u7a76\u8868\u660e\u5c0f\u80f6\u8d28\u7ec6\u80de\u7126\u4ea1\u53ca\u5176\u4ecb\u5bfc\u7684\u795e\u7ecf\u708e\u75c7\u53cd\u5e94\u53ef\u80fd\u662f\u5bfc\u81f4\u7f3a\u8840\u6027\u8111\u635f\u4f24\u7684\u91cd\u8981\u673a\u5236\u3002\u6291\u5236\u5c0f\u80f6\u8d28\u7ec6\u80de\u7684\u795e\u7ecf\u6bd2\u6027\u4f5c\u7528\u53ef\u80fd\u662f\u6cbb\u7597\u7f3a\u8840\u6027\u4e2d\u98ce\u7684\u65b0\u7b56\u7565\u3002<\/p>\n<\/section>\n<section id=\"sec0085\">\n<h3 id=\"sect0105\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">3.4. \u7ec6\u80de\u7126\u4ea1\u548c\u5185\u76ae\u7ec6\u80de<\/h3>\n<p id=\"p0130\">\u5185\u76ae\u7ec6\u80de\u6784\u6210\u8840\u8111\u5c4f\u969c\u7684\u7b2c\u4e00\u9053\u5c4f\u969c\uff0c\u4e3a\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 claudin \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/claudin\">\u514b\u52b3\u4e01<\/a>,\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7c98\u9644\u5206\u5b50\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-adhesion-molecule\">\u7c98\u9644\u5206\u5b50<\/a>\u00a0\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/extracellular-matrix\">\u7ec6\u80de\u5916\u57fa\u8d28<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib182\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib182\"><span class=\"anchor-text\">[182]<\/span><\/a>\u3002\u8111\u7f3a\u8840\u671f\u95f4\uff0c\u514d\u75ab\u708e\u75c7\u53cd\u5e94\u548c\u6c27\u5316\u5e94\u6fc0\u4f1a\u635f\u5bb3\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5185\u76ae\u7ec6\u80de\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/endothelial-cell\">\u5167\u76ae\u7d30\u80de<\/a>\u00a0\u7834\u574f\u8840\u8111\u5c4f\u969c\u7684\u5b8c\u6574\u6027\uff0c\u5bfc\u81f4\u8840\u7ba1\u6e90\u6027\u6c34\u80bf\u3001\u51fa\u8840\u6027\u8f6c\u5316\u548c\u6b7b\u4ea1\u7387\u589e\u52a0\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib183\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib183\"><span class=\"anchor-text\">[183]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib184\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib184\"><span class=\"anchor-text\">[184]<\/span><\/a>\u3002\u8111\u7f3a\u8840\u540e\uff0cNLRP3\u5728\u795e\u7ecf\u5143\u3001\u5c0f\u80f6\u8d28\u7ec6\u80de\u548c\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u4e2d\u8868\u8fbe\u4e0a\u8c03\uff0c\u6c89\u9ed8NLRP3\u57fa\u56e0\u53ef\u4ee5\u51cf\u5c11\u5c0f\u9f20\u8111\u6897\u6b7b\u4f53\u79ef\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5927\u8111\u4e2d\u52a8\u8109\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/middle-cerebral-artery\">\u5927\u8111\u4e2d\u52a8\u8109<\/a>\u00a0\u7f3a\u8840\u5e76\u964d\u4f4e\u8840\u8111\u5c4f\u969c\u7684\u901a\u900f\u6027\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib185\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib185\"><span class=\"anchor-text\">[185]<\/span><\/a>\u3002\u738b\u7b49\u4eba\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib186\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib186\"><span class=\"anchor-text\">[186]<\/span><\/a>\u00a0\u8bc1\u5b9e\u8111\u7f3a\u8840\u53ef\u8bf1\u5bfc\u5fae\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7126\u4ea1\uff0c\u52a0\u91cd\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u3002\u4ed6\u4eec\u8fd8\u53d1\u73b0\u8fc7\u6c27\u5316\u7269\u9176\u4f53\u589e\u6b96\u6fc0\u6d3b\u53d7\u4f53\u03b3\u8f85\u6fc0\u6d3b\u56e0\u5b501\u03b1\uff08PGC-1\u03b1\uff09\u7684\u6fc0\u6d3b\u53ef\u663e\u8457\u964d\u4f4e\u7126\u4ea1\u76f8\u5173\u86cb\u767d\u7684\u8868\u8fbe\uff0c\u589e\u52a0ZO-1\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 Occludin \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/occludin\">\u95ed\u5408\u86cb\u767d<\/a>\u00a0\u8111\u5fae\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u4e2d\u7684\u86cb\u767d\u8d28\uff0c\u4ece\u800c\u4fdd\u62a4\u8840\u8111\u5c4f\u969c\u7684\u5b8c\u6574\u6027\u3002\u6b64\u5916\uff0c\u7814\u7a76\u53d1\u73b0\uff0c\u8111\u5fae\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7126\u4ea1\u53ef\u80fd\u4f1a\u589e\u52a0IS\u672f\u540e\u51fa\u8840\u7684\u53ef\u80fd\u6027\uff0c\u5bfc\u81f4\u4e25\u91cd\u5e76\u53d1\u75c7\uff0c\u5982\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8111\u51fa\u8840\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebral-hemorrhage\">\u8111\u6ea2\u8840<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib187\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib187\"><span class=\"anchor-text\">[187]<\/span><\/a>.<\/p>\n<div>\n<p id=\"p0135\">\u8111\u7f3a\u8840\u4e0e\u7ec6\u80de\u7126\u4ea1\u4e4b\u95f4\u7684\u5173\u8054\u603b\u7ed3\u4e8e\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#fig0010\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"fig0010\"><span class=\"anchor-text\">\u56fe 2<\/span><\/a>.<\/p>\n<figure id=\"fig0010\" class=\"figure text-xs\"><img decoding=\"async\" src=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr2.jpg\" alt=\"Fig. 2\" height=\"362\" aria-describedby=\"cap0010\" \/><\/p>\n<ol class=\"u-margin-s-bottom\">\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"\u4e0b\u8f7d\u9ad8\u5206\u8fa8\u7387\u56fe\u7247 (274KB)\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr2_lrg.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">\u4e0b\u8f7d \uff1a\u00a0<span class=\"download-link-title\">\u4e0b\u8f7d\u9ad8\u5206\u8fa8\u7387\u56fe\u7247 (274KB)<\/span><\/span><\/a><\/li>\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"\u4e0b\u8f7d\u5168\u5c3a\u5bf8\u56fe\u7247\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr2.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">\u4e0b\u8f7d \uff1a\u00a0<span class=\"download-link-title\">\u4e0b\u8f7d\u5168\u5c3a\u5bf8\u56fe\u7247<\/span><\/span><\/a><\/li>\n<\/ol>\n<p id=\"sp0010\"><span class=\"label\">\u56fe 2<\/span>\u3002 IS\u540e\u8840\u7ba1\u795e\u7ecf\u5143\u7126\u4ea1\u673a\u5236\u7efc\u8ff0\u3010\u8840\u7ba1\u795e\u7ecf\u5143\uff08\u7531\u5c0f\u80f6\u8d28\u7ec6\u80de\u3001\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u3001\u795e\u7ecf\u5143\u3001\u795e\u7ecf\u5143\u7ec4\u6210\uff09\u7126\u4ea1\u7684\u5206\u5b50\u673a\u5236\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascular-endothelial-cell\">\u8840\u7ba1\u5185\u76ae\u7ec6\u80de<\/a>\uff0c\u5468\u7ec6\u80de\uff09\u5728 IS \u4e4b\u540e\u3002IRF\uff1a\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5e72\u6270\u7d20\u8c03\u8282\u56e0\u5b50\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/interferon-regulatory-factor\">\u5e72\u6270\u7d20\u8c03\u8282\u56e0\u5b50<\/a>;\u5e72\u6270\u7d20\uff1a\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5e72\u6270\u7d20\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/interferon\">\u5e72\u6270\u7d20<\/a>; CASP\uff1a\u534a\u80f1\u5929\u51ac\u9176\uff1b GPX4\uff1a\u8c37\u80f1\u7518\u80bd\u8fc7\u6c27\u5316\u7269\u91764]\u3002<\/p>\n<\/figure>\n<\/div>\n<\/section>\n<\/section>\n<section id=\"sec0090\">\n<h2 id=\"sect0110\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">4.\u7126\u4ea1\u6291\u5236\u5242\u6cbb\u7597IS\u7684\u6f5c\u529b<\/h2>\n<p id=\"p0140\">\u8fd1\u5e74\u6765\uff0c\u7126\u4ea1\u6291\u5236\u5242\u5728IS\u4e2d\u7684\u7814\u7a76\u5907\u53d7\u5173\u6ce8\u3002\u6881\u7b49\u4eba\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib188\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib188\"><span class=\"anchor-text\">[188]<\/span><\/a>\u00a0\u53d1\u73b0 Caspase-1 \u6291\u5236\u5242 VX-765 \u53ef\u4ee5\u964d\u4f4e Caspase-1\u3001ASC\u3001GSDMD \u548c IL-1\u03b2\uff0c\u540c\u65f6\u4e0a\u8c03\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7d27\u5bc6\u8fde\u63a5\u86cb\u767d\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tight-junction-protein\">\u7d27\u5bc6\u8fde\u63a5\u86cb\u767d<\/a>\u00a0\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u91d1\u5c5e\u86cb\u767d\u9176\u7ec4\u7ec7\u6291\u5236\u5242\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/metalloprotease-inhibitor\">\u91d1\u5c5e\u86cb\u767d\u9176\u7ec4\u7ec7\u6291\u5236\u5242<\/a>\uff0c\u4fdd\u62a4\u8840\u8111\u5c4f\u969c\u7684\u5b8c\u6574\u6027\u3002\u6b64\u5916\uff0cVX-765\u8fd8\u80fd\u4fc3\u8fdb\u5c0f\u80f6\u8d28\u7ec6\u80de\u7531M1\u578b\u5411M2\u578b\u8f6c\u5316\uff0c\u51cf\u8f7b\u5c0f\u80f6\u8d28\u7ec6\u80de\u4ecb\u5bfc\u7684\u708e\u75c7\u53cd\u5e94\uff0c\u53d1\u6325\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib189\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib189\"><span class=\"anchor-text\">[189]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib190\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib190\"><span class=\"anchor-text\">[190]<\/span><\/a>MCC950\u662f\u4e00\u79cd\u9009\u62e9\u6027NLRP3\u6291\u5236\u5242\uff0c\u7814\u7a76\u53d1\u73b0MCC950\u53ef\u4ee5\u964d\u4f4e\u7f3a\u8840\u534a\u6697\u5e26\u4e2dNLRP3\u3001Caspase-1\u3001IL-1\u03b2\u7684\u8868\u8fbe\uff0c\u5bf9\u5c0f\u9f20\u5c40\u7076\u6027\u8111\u7f3a\u8840\u5177\u6709\u4fdd\u62a4\u4f5c\u7528\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib191\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib191\"><span class=\"anchor-text\">[191]<\/span><\/a>\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u4e00\u4e9b\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 microRNA \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microrna\">\u5fae\u5c0fRNA<\/a>\u00a0\u53ef\u80fd\u6291\u5236\u8111\u7f3a\u8840\u6a21\u578b\u7ec6\u80de\u7126\u4ea1\uff0c\u53d1\u6325\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib192\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib192\"><span class=\"anchor-text\">[192]<\/span><\/a>. LP17 \u53ef\u80fd\u6291\u5236\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u9ad3\u7cfb\u7ec6\u80de\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/myeloid-cell\">\u9aa8\u9ad3\u7ec6\u80de<\/a>\u00a0\u89e6\u53d1\u53d7\u4f53-1\uff0c\u4ece\u800c\u6291\u5236\u6c27\u5316\u5e94\u6fc0\u548c\u7ec6\u80de\u7126\u4ea1\uff0c\u51cf\u8f7b\u8111\u7f3a\u8840\u5f15\u8d77\u7684\u795e\u7ecf\u5143\u635f\u4f24\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib192\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib192\"><span class=\"anchor-text\">[192]<\/span><\/a>.\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7ec4\u6c28\u9178\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/histidine\">\u7ec4\u6c28\u9178<\/a>\u00a0\u53ef\u80fd\u901a\u8fc7\u8c03\u8282\u817a\u82f7\u9178\u6d3b\u5316\u86cb\u767d\u6fc0\u9176\/\u7cd6\u539f\u5408\u9176\u6fc0\u9176-3\u03b2\u4fe1\u53f7\u901a\u8def\u6291\u5236NLRP3\u4ecb\u5bfc\u7684\u7ec6\u80de\u7126\u4ea1\uff0c\u4ece\u800c\u53d1\u6325\u6297CIRI\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib193\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib193\"><span class=\"anchor-text\">[193]<\/span><\/a>\u3002\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u53d7\u4f53\u53ef\u80fd\u6291\u5236 CIRI \u540e NLRP3 \u4ecb\u5bfc\u7684\u795e\u7ecf\u5143\u7126\u4ea1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib194\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib194\"><span class=\"anchor-text\">[194]<\/span><\/a>\u8102\u8d28\u9187\u4ecb\u5bfc\u7684\u8fc7\u6c27\u5316\u7269\u9176\u4f53\u589e\u6b96\u6fc0\u6d3b\u53d7\u4f53\u03b1-\u8c37\u6c28\u9178\u8349\u9170\u4e59\u9178\u8f6c\u6c28\u91761\u8f74\u53ef\u80fd\u6291\u5236IS\u540e\u5185\u76ae\u7ec6\u80de\u7126\u4ea1\u5e76\u6539\u5584\u7f3a\u8840\u6027\u8111\u635f\u4f24\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib195\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib195\"><span class=\"anchor-text\">[195]<\/span><\/a>\u3002 CHRFAM7A \u7684\u8fc7\u5ea6\u8868\u8fbe\u53ef\u80fd\u6291\u5236 NLRP3\/caspase-1 \u901a\u8def\u4f9d\u8d56\u6027\u5c0f\u80f6\u8d28\u7ec6\u80de\u7126\u4ea1\u5e76\u51cf\u5f31 CIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib196\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib196\"><span class=\"anchor-text\">[196]<\/span><\/a>. TP53\u8bf1\u5bfc\u7684\u7cd6\u9175\u89e3\u548c\u51cb\u4ea1\u8c03\u8282\u5242\u53ef\u80fd\u51cf\u8f7b\u8111\u7f3a\u8840\u5f15\u8d77\u7684\u5c0f\u80f6\u8d28\u7ec6\u80de\u7126\u4ea1\u548c\u7f3a\u8840\u6027\u8111\u635f\u4f24\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib197\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib197\"><span class=\"anchor-text\">[197]<\/span><\/a>\u3002\u6b64\u5916\uff0c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5916\u6ccc\u4f53\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/exosome\">\u5916\u6ccc\u4f53<\/a>\u00a0\u6765\u6e90\u4e8e\u7f3a\u6c27\u9aa8\u9ad3\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mesenchymal-stem-cell\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de<\/a>\u00a0\u53ef\u80fd\u8c03\u8282\u5c0f\u80f6\u8d28\u7ec6\u80de M1\/M2 \u8868\u578b\u4ee5\u7f13\u89e3 CIRI \u8bf1\u5bfc\u7684\u795e\u7ecf\u5143\u7126\u4ea1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib198\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib198\"><span class=\"anchor-text\">[198]<\/span><\/a>\u3002\u7f3a\u6c27\u9884\u5904\u7406\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u55c5\u89c9\u7c98\u819c\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/olfactory-mucosa\">\u55c5\u9ecf\u819c<\/a>\u00a0\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u53ef\u80fd\u901a\u8fc7\u6fc0\u6d3b\u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b501\u03b1\u6291\u5236\u8111\u7f3a\u8840\u5f15\u8d77\u7684\u5c0f\u80f6\u8d28\u7ec6\u80de\u7126\u4ea1\u548c\u51cb\u4ea1\uff0c\u4ece\u800c\u964d\u4f4eCIRI\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib199\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib199\"><span class=\"anchor-text\">[199]<\/span><\/a>.<\/p>\n<p id=\"p0145\">GSDMD\u4f5c\u4e3a\u7ec6\u80de\u7126\u4ea1\u7684\u6267\u884c\u8005\uff0c\u662f\u6cbb\u7597IS\u7684\u7406\u60f3\u5206\u5b50\u9776\u70b9\u3002\u7136\u800c\uff0c\u76ee\u524dGSDMD\u6291\u5236\u5242\u7684\u7814\u7a76\u4ecd\u5904\u4e8e\u8d77\u6b65\u9636\u6bb5\uff0c\u7f3a\u4e4fGSDMD\u6291\u5236\u5242\u6cbb\u7597\u7f3a\u8840\u6027\u8111\u5352\u4e2d\u7597\u6548\u7684\u8bc1\u636e\u3002\u6700\u8fd1\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u4e00\u4e9b\u5929\u7136\u690d\u7269\u6210\u5206\u53ef\u80fd\u901a\u8fc7\u8c03\u8282\u7126\u4ea1\u9014\u5f84\u6765\u6cbb\u7597 IS\u3002<\/p>\n<\/section>\n<section id=\"sec0095\">\n<h2 id=\"sect0115\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">5. \u5929\u7136\u4ea7\u7269\u4f5c\u4e3a\u65b0\u578b\u7126\u4ea1\u6291\u5236\u5242\uff0c\u6210\u4e3a\u6cbb\u7597IS\u7684\u6f5c\u5728\u5019\u9009\u8005<\/h2>\n<p id=\"p0150\">\u5929\u7136\u4ea7\u7269\u56e0\u5177\u6709\u591a\u6210\u5206\u3001\u591a\u9776\u70b9\u3001\u591a\u9014\u5f84\u3001\u4f4e\u6bd2\u7b49\u4f18\u70b9\uff0c\u5728\u8111\u6897\u6b7b\/\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u9632\u6cbb\u4e2d\u5177\u6709\u663e\u8457\u4f18\u52bf\uff0c\u6709\u826f\u597d\u7684\u5e94\u7528\u524d\u666f\u3002\u76ee\u524d\uff0c\u5929\u7136\u4ea7\u7269\u5728\u8111\u6897\u6b7b\/\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u9632\u6cbb\u4e2d\u7684\u7814\u7a76\u9010\u6e10\u589e\u591a\uff0c\u6d89\u53ca\u591a\u79cd\u4fdd\u62a4\u673a\u5236\u3002\u672c\u8282\u5bf9\u5929\u7136\u4ea7\u7269\u3001\u52a8\u7269\u6216\u7ec6\u80de\u6a21\u578b\u3001\u7ed9\u836f\u65b9\u5f0f\u3001\u7ed9\u836f\u5242\u91cf\u3001\u6cbb\u7597\u65f6\u95f4\u3001\u6548\u679c\u3001\u6cbb\u7597\u673a\u5236\uff08\u4fe1\u53f7\u901a\u8def\uff09\u8fdb\u884c\u7efc\u8ff0\uff0c\u4e3a\u5feb\u901f\u5bfb\u627e\u5b89\u5168\u3001\u6709\u6548\u3001\u4f4e\u6bd2\u3001\u8c03\u63a7\u7ec6\u80de\u7126\u4ea1\u7528\u4e8e\u9632\u6cbbIS\/CIRI\u7684\u5929\u7136\u690d\u7269\u6210\u5206\u63d0\u4f9b\u7406\u8bba\u652f\u6301\u3002<\/p>\n<section id=\"sec0100\">\n<h3 id=\"sect0120\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">5.1. \u5929\u7136\u690d\u7269\u6210\u5206<\/h3>\n<div>\n<p id=\"p0155\">\u5929\u7136\u690d\u7269\u6210\u5206\u7684\u4e3b\u8981\u7ed3\u6784\u5982\u56fe\u6240\u793a\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#fig0015\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"fig0015\"><span class=\"anchor-text\">\u56fe 3<\/span><\/a>.<\/p>\n<figure id=\"fig0015\" class=\"figure text-xs\"><img decoding=\"async\" src=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr3.jpg\" alt=\"Fig. 3\" height=\"397\" aria-describedby=\"cap0015\" \/><\/p>\n<ol class=\"u-margin-s-bottom\">\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"\u4e0b\u8f7d\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf (208KB)\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr3_lrg.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">\u4e0b\u8f7d \uff1a\u00a0<span class=\"download-link-title\">\u4e0b\u8f7d\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf (208KB)<\/span><\/span><\/a><\/li>\n<li><a class=\"anchor download-link u-font-sans u-display-inline anchor-default\" title=\"\u4e0b\u8f7d\u5168\u5c3a\u5bf8\u56fe\u7247\" href=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0753332222013889-gr3.jpg\" target=\"_blank\" rel=\"noopener\" download=\"\"><span class=\"anchor-text\">\u4e0b\u8f7d \uff1a\u00a0<span class=\"download-link-title\">\u4e0b\u8f7d\u5168\u5c3a\u5bf8\u56fe\u7247<\/span><\/span><\/a><\/li>\n<\/ol>\n<p id=\"sp0015\"><span class=\"label\">\u56fe 3<\/span>\u3002\u5929\u7136\u690d\u7269\u7684\u4e3b\u8981\u7ed3\u6784\u6210\u5206\u3002<\/p>\n<\/figure>\n<\/div>\n<section id=\"sec0105\">\n<h4 id=\"sect0125\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.1.\u5929\u9ebb\u7d20 (GAS)<\/h4>\n<p id=\"p0160\">GAS \u662f\u4e00\u79cd\u4ece\u8349\u836f\u4e2d\u63d0\u53d6\u7684\u591a\u529f\u80fd\u5316\u5408\u7269\uff0c\u00a0<em><a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5929\u9ebb\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/gastrodia-elata\">\u5929\u9ebb<\/a><\/em>\uff0c\u4e0e\u5404\u79cd\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u836f\u7406\u6d3b\u6027\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/pharmacological-activity\">\u836f\u7406\u6d3b\u6027<\/a>\uff0c\u4f8b\u5982\u6297\u6c27\u5316\u548c\u6297\u708e\u6d3b\u6027\u3002\u6b64\u5916\uff0cGAS \u5df2\u88ab\u8bc1\u660e\u53ef\u4ee5\u901a\u8fc7\u8c03\u8282\u4fc3\u51cb\u4ea1\u56e0\u5b50\uff08\u5305\u62ec caspase-3 \u88c2\u89e3\u3001IL-18 \u548c IL-1\u03b2\uff09\u663e\u7740\u51cf\u8f7b\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u75c7\u72b6\u3002\u591a\u9879\u7814\u7a76\u8868\u660e\uff0cGAS \u53ef\u6539\u5584\u8111\u7f3a\u8840\u635f\u4f24\u5e76\u964d\u4f4e\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6d3b\u6027\u6c27\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/reactive-oxygen-species\">\u6d3b\u6027\u6c27<\/a>\u00a0\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inflammatory-cytokine\">\u708e\u6027\u7ec6\u80de\u56e0\u5b50<\/a>\u00a0\u5728\u5c0f\u9f20\u4e2d\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib200\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib200\"><span class=\"anchor-text\">[200]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib201\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib201\"><span class=\"anchor-text\">[201]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib202\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib202\"><span class=\"anchor-text\">[202]<\/span><\/a>. Lu \u7b49\u7814\u7a76\u53d1\u73b0\uff0cGAS \u53ef\u901a\u8fc7\u9776\u5411 NLRP3\/caspase-1 \u8f74\u6765\u6539\u5584\u4e0e\u5fc3\u810f\u5fae\u8840\u7ba1\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u76f8\u5173\u7684\u7ec6\u80de\u7126\u4ea1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib203\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib203\"><span class=\"anchor-text\">[203]<\/span><\/a>. GAS \u53ef\u4ee5\u663e\u8457\u6539\u5584\u00a0<a class=\"topic-link\" title=\"\u901a\u8fc7 ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u795e\u7ecf\u529f\u80fd\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nervous-system-physiology\">\u795e\u7ecf\u529f\u80fd<\/a>\u00a0\u5f97\u5206\u5e76\u51cf\u5c11\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8111\u6897\u585e\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-infarction\">\u8111\u6897\u585e<\/a>\u3002\u540c\u65f6\uff0cGAS \u901a\u8fc7\u4e0b\u8c03 NLRP3\u3001\u708e\u75c7\u56e0\u5b50\uff08IL-1\u03b2\u3001IL-18\uff09\u548c caspase-1 \u6291\u5236\u7ec6\u80de\u7126\u4ea1\u3002\u6b64\u5916\uff0cGAS \u901a\u8fc7\u8c03\u8282 lncRNA NEAT1\/miR-22-3p \u8f74\u51cf\u8f7b\u7f3a\u8840\u518d\u704c\u6ce8\u8bf1\u5bfc\u7684\u795e\u7ecf\u7ec6\u80de\u708e\u75c7\u3002 GAS\u901a\u8fc7\u8c03\u8282lncRNA NEAT1\/miR-22-3p\u8f74\u663e\u7740\u51cf\u8f7b\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib204\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib204\"><span class=\"anchor-text\">[204]<\/span><\/a>\u3002\u56e0\u6b64\uff0cGAS\u53ef\u4ee5\u4f5c\u4e3a\u4e00\u79cd\u6f5c\u5728\u7684\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u836f\u7269\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chemotherapeutic-agent\">\u836f\u54c1<\/a>\u00a0\u7528\u4e8e\u6cbb\u7597 CIRI\u3002<\/p>\n<\/section>\n<section id=\"sec0110\">\n<h4 id=\"sect0130\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.2. \u4e39\u53c2\u916e\u2161A<\/h4>\n<p id=\"p0165\"><a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u4e39\u53c2\u916e IIA \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tanshinone-iia\">\u4e39\u53c2\u916eIIA<\/a>\u00a0\u662f\u4e3b\u8981\u6d3b\u6027\u6210\u5206\u00a0<em><a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u4e39\u53c2\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/salvia-miltiorrhiza\">\u4e39\u53c2<\/a><\/em>. \u5b83\u5e7f\u6cdb\u5e94\u7528\u4e8e\u6cbb\u7597\u5fc3\u8840\u7ba1\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8111\u8840\u7ba1\u75be\u75c5\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebrovascular-disease\">\u8111\u8840\u7ba1\u75c5<\/a>\u00a0\u7531\u4e8e\u5176\u6297\u6c27\u5316\u548c\u6539\u5584\u8840\u6db2\u5faa\u73af\u7684\u4f5c\u7528\u3002\u8521\u7b49\u4eba\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib205\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib205\"><span class=\"anchor-text\">[205]<\/span><\/a>\u00a0\u7814\u7a76\u53d1\u73b0\u4e39\u53c2\u916eIIA\u53ef\u6709\u6548\u964d\u4f4eNLRP3\u708e\u75c7\u4fe1\u53f7\u901a\u8def\u4e2dIL-1\u03b2\u548cIL-18\u7684\u8868\u8fbe\uff0c\u4e14\u5176\u4f5c\u7528\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u3002\u8fd9\u5c31\u8bf4\u660e\u4e39\u53c2\u916e IIA \u901a\u8fc7\u6291\u5236 NLRP3 \u4fe1\u53f7\u901a\u8def\u7684\u6fc0\u6d3b,\u4ece\u800c\u51cf\u8f7b\u8111\u5352\u4e2d\u540e\u6c27\u7cd6\u5265\u593a\/\u518d\u704c\u6ce8\u5bf9 BV-2 \u7ec6\u80de\u7684\u635f\u4f24.<\/p>\n<\/section>\n<section id=\"sec0115\">\n<h4 id=\"sect0135\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.3. \u76ca\u6bcd\u8349\u78b1<\/h4>\n<p id=\"p0170\"><a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 Leonurine \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/leonurine\">\u76ca\u6bcd\u8349\u78b1<\/a>\u00a0\u5728\u00a0<em><a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 Leonuri \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/leonurus\">\u83b1\u5965\u52aa\u91cc<\/a><\/em><em>\u00a0\u9999\u8349<\/em>\u00a0\u6539\u5584\u6162\u6027\u8111\u7f3a\u8840\u5927\u9f20\u7684\u5b66\u4e60\u8bb0\u5fc6\u80fd\u529b\uff0c\u964d\u4f4eNLRP3\u7684\u8868\u8fbe\uff0c\u63a8\u6d4b\u53ef\u80fd\u662f\u901a\u8fc7\u6297\u708e\u4f5c\u7528\u8fbe\u5230\u4fdd\u62a4\u795e\u7ecf\u7684\u76ee\u7684\u3002NLRP3\u7684\u6fc0\u6d3b\u4fc3\u8fdbCaspase-1\u524d\u4f53\u8f6c\u5316\u4e3aCaspase-1\uff0c\u4fc3\u8fdbIL-1\u03b2\u548cIL-18\u7684\u4ea7\u751f\uff0c\u8fdb\u800c\u5f15\u8d77\u4e00\u7cfb\u5217\u708e\u75c7\u53cd\u5e94\u3002\u76ca\u6bcd\u8349\u78b1\u53ef\u80fd\u901a\u8fc7\u6291\u5236\u7ec6\u80de\u7126\u4ea1\uff0c\u51cf\u8f7b\u8111\u7ec4\u7ec7\u708e\u75c7\u53cd\u5e94\uff0c\u964d\u4f4e\u795e\u7ecf\u529f\u80fd\u7f3a\u635f\u8bc4\u5206\uff0c\u5177\u6709\u826f\u597d\u7684\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib206\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib206\"><span class=\"anchor-text\">[206]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0120\">\n<h4 id=\"sect0140\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.4.\u828d\u836f\u7519<\/h4>\n<p id=\"p0175\"><a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u828d\u836f\u82f7\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/paeoniflorin\">\u828d\u836f\u7519<\/a>\u00a0\u6765\u81ea\u4e8e\u4e3b\u8981\u6210\u5206\u00a0<em><a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 Paeoniae radix rubra \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/radix-paeoniae-rubra\">\u8d64\u828d<\/a><\/em>. \u828d\u836f\u82f7\u662f\u828d\u836f\u603b\u82f7\u7684\u4e3b\u8981\u6d3b\u6027\u6210\u5206\u00a0<a class=\"topic-link\" title=\"\u901a\u8fc7 ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7261\u4e39\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/paeonia\">\u7261\u4e39<\/a>\u00a0\uff08TGP\uff09\uff0c\u8fd8\u5177\u6709\u826f\u597d\u7684\u6297\u708e\u548c\u514d\u75ab\u8c03\u8282\u4f5c\u7528\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib207\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib207\"><span class=\"anchor-text\">[207]<\/span><\/a>. TGP \u548c\u828d\u836f\u82f7\u8fd8\u5177\u6709\u591a\u79cd\u836f\u7406\u6d3b\u6027\uff0c\u4f8b\u5982\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u89e3\u75c9\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antispasmodic\">\u89e3\u75c9<\/a>,\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6b62\u75db\u836f\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/anodyne\">\u9547\u75db\u5242<\/a>\uff0c \u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8840\u7ba1\u8212\u5f20\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vasodilatation\">\u8840\u7ba1\u8212\u5f20<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib208\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib208\"><span class=\"anchor-text\">[208]<\/span><\/a>Zulifiya Ekemu\u7b49\u7814\u7a76\u53d1\u73b0\u6025\u6027\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u540e\uff0c\u8111\u5185\u5c0f\u80f6\u8d28\u7ec6\u80de\u6d3b\u5316\u53ca\u795e\u7ecf\u5143\u7126\u4ea1\u660e\u663e\uff0cNLRP3\u6d3b\u5316\u589e\u591a\uff0cCaspase-1\u53caIL-1\u03b2\u4e0a\u8c03\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib209\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib209\"><span class=\"anchor-text\">[209]<\/span><\/a>\u3002\u828d\u836f\u7519\u663e\u7740\u964d\u4f4e\u795e\u7ecf\u529f\u80fd\u8bc4\u5206\uff0c\u663e\u7740\u964d\u4f4e\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8111\u6897\u585e\u5927\u5c0f\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-infarction-size\">\u8111\u6897\u585e\u9762\u79ef<\/a>\uff0c\u663e\u7740\u4e0b\u8c03 Iba1 \u8868\u8fbe\uff0c\u5e76\u663e\u7740\u6539\u5584\u795e\u7ecf\u5143\u72b6\u6001\u3002\u6b64\u5916\uff0c\u828d\u836f\u82f7\u5e72\u9884\u540eNLRP3\u3001Caspase-1\u548cIL-1\u03b2\u7684\u8868\u8fbe\u663e\u7740\u964d\u4f4e\u3002\u63d0\u793a\u828d\u836f\u82f7\u53ef\u80fd\u901a\u8fc7\u6291\u5236NLRP3\u548cCaspase-1\u7684\u6fc0\u6d3b\uff0c\u51cf\u5c11\u5c0f\u80f6\u8d28\u7ec6\u80de\u7684\u6fc0\u6d3b\uff0c\u6291\u5236\u795e\u7ecf\u5143\u7126\u4ea1\uff0c\u6539\u5584ACI\u4ecb\u5bfc\u7684\u795e\u7ecf\u635f\u4f24\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib209\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib209\"><span class=\"anchor-text\">[209]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0125\">\n<h4 id=\"sect0145\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.5\u3002\u4e01\u57fa\u82ef\u915e<\/h4>\n<p id=\"p0180\"><span class=\"small-caps\">L<\/span>-\u4e01\u57fa\u82ef\u915e\u6700\u65e9\u4ece\u6c34\u82b9\u79cd\u5b50\u4e2d\u5206\u79bb\u5f97\u5230\uff0c\u540e\u6765\u53ef\u4ee5\u4eba\u5de5\u5408\u6210\u3002\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u4e01\u57fa\u82ef\u915e\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/butylphthalide\">\u4e01\u57fa\u82ef\u915e<\/a>\u00a0\u5177\u6709\u72ec\u7279\u7684\u53cc\u91cd\u4f5c\u7528\uff0c\u4e0d\u4ec5\u53ef\u4ee5\u91cd\u5efa\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5fae\u5faa\u73af\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microcirculation\">\u5fae\u5faa\u73af<\/a>\u00a0\u5e76\u589e\u52a0\u7f3a\u8840\u518d\u704c\u6ce8\uff0c\u4ece\u800c\u4fdd\u62a4\u8840\u7ba1\u7684\u5b8c\u6574\u6027\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8840\u7ba1\u7ed3\u6784\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/blood-vessel\">\u8840\u7ba1\u7ed3\u6784<\/a>\u3001\u6062\u590d\u8840\u7ba1\u76f4\u5f84\u3001\u589e\u52a0\u7f3a\u8840\u533a\u8840\u6d41\u91cf\u53ca\u5468\u56f4\u8840\u7ba1\u6570\u91cf\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5fae\u8840\u7ba1\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/microvessel\">\u5fae\u8840\u7ba1<\/a>\uff0c\u8fd8\u80fd\u4fdd\u62a4\u7ebf\u7c92\u4f53\uff0c\u51cf\u5c11\u7ec6\u80de\u6b7b\u4ea1\uff0c\u4ece\u800c\u4fdd\u62a4\u7ebf\u7c92\u4f53\u7ed3\u6784\u7684\u5b8c\u6574\u6027\uff0c\u63d0\u9ad8\u7ebf\u7c92\u4f53\u590d\u5408\u9176IV\u7684\u6d3b\u6027\uff0c\u63d0\u9ad8\u7ebf\u7c92\u4f53ATP\u9176\u7684\u6d3b\u6027\uff0c\u7ef4\u6301\u7ebf\u7c92\u4f53\u7684\u7a33\u5b9a\u6027\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7ebf\u7c92\u4f53\u819c\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitochondrial-membrane\">\u7ebf\u7c92\u4f53\u819c<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib210\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib210\"><span class=\"anchor-text\">[210]<\/span><\/a>\u3002\u6700\u65b0\u7814\u7a76\u8868\u660e\uff0c\u4e01\u82ef\u915e\u53ef\u80fd\u901a\u8fc7NLRP3\u708e\u75c7\u5c0f\u4f53\u4fe1\u53f7\u901a\u8def\u4ee5\u5242\u91cf\u4f9d\u8d56\u6027\u65b9\u5f0f\u5f71\u54cdCIRI\u5927\u9f20\u7126\u4ea1\u3002<\/p>\n<\/section>\n<section id=\"sec0130\">\n<h4 id=\"sect0150\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.6. \u706f\u76cf\u82b1\u7d20<\/h4>\n<p id=\"p0185\"><a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u706f\u76cf\u82b1\u7d20\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/breviscapine\">\u706f\u76cf\u82b1\u7d20<\/a>\u00a0\u63d0\u53d6\u81ea\u00a0<em><a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u706f\u76cf\u82b1\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/erigeron-breviscapus\">\u706f\u76cf\u82b1<\/a><\/em>\u00a0\uff08Vant\u3002\uff09\u624b\u3002 -\u9a6c\u5179\u3002\u706f\u76cf\u82b1\u7d20\u662f\u4e00\u79cd\u6df7\u5408\u7269\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u706f\u76cf\u4e59\u7d20\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/scutellarin\">\u706f\u76cf\u4e59\u7d20<\/a>\u00a0\u4e3b\u8981\u542b\u706f\u76cf\u82b1\u7d20\uff0c\u542b\u6709\u5c11\u91cf\u706f\u76cf\u82b1\u82f7\uff0c\u5177\u6709\u6269\u5f20\u8111\u8840\u7ba1\uff0c\u964d\u4f4e\u8111\u8840\u7ba1\u963b\u529b\uff0c\u589e\u52a0\u8111\u8840\u6d41\u91cf\uff0c\u6539\u5584\u5fae\u5faa\u73af\uff0c\u6297\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8840\u5c0f\u677f\u805a\u96c6\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/thrombocyte-aggregation\">\u8840\u5c0f\u677f\u805a\u96c6<\/a>\u6700\u65b0\u7814\u7a76\u8868\u660e\uff0c\u706f\u76cf\u82b1\u7d20\u80fd\u660e\u663e\u6291\u5236NLRP3\u708e\u75c7\u7ec6\u80de\u5728\u708e\u75c7\u7ec6\u80de\u4e2d\u7684\u6fc0\u6d3b\u00a0<a class=\"topic-link\" title=\"\u901a\u8fc7 ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6d77\u9a6c\u4f53\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hippocampus\">\u6d77\u9a6c\u4f53<\/a>\u00a0\u4e0b\u8c03CCI\u5927\u9f20Caspase 1\u3001IL-6\u3001IL-1\u03b2\u86cb\u767d\u8868\u8fbe\uff0c\u6291\u5236Caspase-3\u86cb\u767d\u6d3b\u5316\uff0c\u6291\u5236\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u795e\u7ecf\u5143\u51cb\u4ea1\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroapoptosis\">\u795e\u7ecf\u5143\u51cb\u4ea1<\/a>\u63d0\u793a\u706f\u76cf\u82b1\u7d20\u53ef\u660e\u663e\u6539\u5584CCI\u5927\u9f20\u7684\u8ba4\u77e5\u529f\u80fd\uff0c\u51cf\u8f7b\u7f3a\u8840\u795e\u7ecf\u5143\u7684\u75c5\u7406\u635f\u4f24\uff0c\u5176\u673a\u5236\u53ef\u80fd\u4e0e\u6291\u5236\u8111\u7ec4\u7ec7NLRP3\u708e\u75c7\u5c0f\u4f53\u6d3b\u5316\u53ca\u7ec6\u80de\u7126\u4ea1\u901a\u8def\u6709\u5173\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib211\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib211\"><span class=\"anchor-text\">[211]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0135\">\n<h4 id=\"sect0155\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.7.\u767d\u85dc\u82a6\u9187<\/h4>\n<p id=\"p0190\"><a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u767d\u85dc\u82a6\u9187\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/resveratrol\">\u767d\u85dc\u82a6\u9187<\/a>\u00a0\u662f\u4e00\u79cd\u975e\u9ec4\u916e\u7c7b\u5316\u5408\u7269\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u591a\u915a\u5316\u5408\u7269\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/polyphenol-derivative\">\u591a\u915a\u5316\u5408\u7269<\/a>. \u5b83\u9996\u5148\u4ece\u6839\u4e2d\u5206\u79bb\u51fa\u6765\u00a0<em><a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 Veratrum \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/veratrum\">\u85dc\u82a6<\/a><\/em><em>\u00a0\u5927\u82b1<\/em>\u800c\u767d\u85dc\u82a6\u9187\u5728700\u591a\u79cd\u690d\u7269\u4e2d\u5747\u6709\u53d1\u73b0\uff0c\u7814\u7a76\u8868\u660e\uff0c\u767d\u85dc\u82a6\u9187\u5728\u8c03\u8282\u8111\u6897\u585e\u6c27\u5316\u5e94\u6fc0\u3001\u6291\u5236\u708e\u75c7\u3001\u6539\u5584\u8111\u529f\u80fd\u7b49\u65b9\u9762\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u795e\u7ecf\u4fdd\u62a4\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroprotection\">\u795e\u7ecf\u4fdd\u62a4<\/a>\u767d\u85dc\u82a6\u9187\u4e3b\u8981\u901a\u8fc7\u8c03\u63a7\u5c0f\u80f6\u8d28\u7ec6\u80deNLRP3\u708e\u75c7\u5c0f\u4f53\u3001Caspase-1\u53caZO-1\u8c03\u63a7\u7f3a\u8840\u518d\u704c\u6ce8\u8111\u7ec4\u7ec7\u7ec6\u80de\u7126\u4ea1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib212\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib212\"><span class=\"anchor-text\">[212]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0140\">\n<h4 id=\"sect0160\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.8.\u4e39\u915a\u9178 (SAFI)<\/h4>\n<p id=\"p0195\">\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0cSAFI \u663e\u7740\u589e\u52a0\u795e\u7ecf\u529f\u80fd\u7f3a\u635f\u8bc4\u5206\uff0c\u51cf\u5c11\u6897\u585e\u4f53\u79ef\uff0c\u51cf\u8f7b\u7ec4\u7ec7\u5b66\u635f\u4f24\u00a0<a class=\"topic-link\" title=\"\u901a\u8fc7 ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5927\u8111\u76ae\u5c42\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebral-cortex\">\u5927\u8111\u76ae\u5c42<\/a>\u00a0\u548c MCAO\/R \u6a21\u578b\u4e2d\u7684\u795e\u7ecf\u5143\u51cb\u4ea1\uff0c\u589e\u52a0\u795e\u7ecf\u5143\u6d3b\u529b\u5e76\u51cf\u5c11 OGD \u6a21\u578b\u4e2d\u7684\u795e\u7ecf\u5143\u51cb\u4ea1\u3002SAFI \u8fd8\u5c06\u5c0f\u80f6\u8d28\u7ec6\u80de\u6781\u5316\u6a21\u5f0f\u4ece M1 \u6837\u8868\u578b\u91cd\u5851\u4e3a M2 \u6837\u8868\u578b\uff0c\u5e76\u5728\u4f53\u5916\u548c\u4f53\u5185\u6291\u5236 NLRP3 \u708e\u75c7\u5c0f\u4f53\u7684\u6fc0\u6d3b\u548c NLRP3 \u708e\u75c7\u5c0f\u4f53\/\u7126\u6c27\u76f8\u5173\u86cb\u767d\u7684\u8868\u8fbe\u3002\u8fd9\u8868\u660e SAFI \u53ef\u80fd\u901a\u8fc7\u51cf\u5c11\u795e\u7ecf\u5143\u51cb\u4ea1\u3001\u5c06\u5c0f\u80f6\u8d28\u7ec6\u80de\u8868\u578b\u4ece M1 \u8f6c\u53d8\u4e3a M2 \u4ee5\u53ca\u6291\u5236\u5c0f\u80f6\u8d28\u7ec6\u80de\u4e2d\u7684 NLRP3 \u708e\u75c7\u5c0f\u4f53\/\u7126\u6c27\u76f8\u5173\u86cb\u767d\u53d1\u6325\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib213\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib213\"><span class=\"anchor-text\">[213]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0145\">\n<h4 id=\"sect0165\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.9. \u7532\u58f3\u7d20<\/h4>\n<p id=\"p0200\"><a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 Hispidulin \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hispidulin\">\u7ec4\u86cb\u767d<\/a>\u00a0\u662f\u4e00\u4e2a\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7c7b\u9ec4\u916e\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/flavonoid\">\u7c7b\u9ec4\u916e<\/a>\u00a0\u5177\u6709\u591a\u79cd\u836f\u7406\u7279\u6027\u7684\u5316\u5408\u7269\uff0c\u662f\u8bb8\u591a\u836f\u7269\u7684\u4e3b\u8981\u6d3b\u6027\u6210\u5206\u4e4b\u4e00\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684\u4eba\u5de5\u667a\u80fd\u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u4e2d\u8349\u836f\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/chinese-herbal-medicine\">\u4e2d\u8349\u836f<\/a>. Hispidulin \u5177\u6709\u5e7f\u6cdb\u7684\u836f\u7406\u7279\u6027\uff0c\u5305\u62ec\u6297\u6c27\u5316\u3001\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6297\u771f\u83cc\u836f\u7269\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antifungal-agent\">\u6297\u771f\u83cc\u5242<\/a>,\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6297\u80bf\u7624\u836f\u7269\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/anticarcinogen\">\u6297\u80bf\u7624<\/a>\u3001\u6297\u9aa8\u8d28\u758f\u677e\u3001\u6297\u708e\u548c\u6297\u7a81\u53d8\u7279\u6027\u3002\u6700\u65b0\u7814\u7a76\u8868\u660e Hispidulin \u6539\u5584\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u795e\u7ecf\u7cfb\u7edf\u75c7\u72b6\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neurologic-disease\">\u795e\u7ecf\u7cfb\u7edf\u75c7\u72b6<\/a>\u00a0\u5728\u5927\u9f20\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u540e\uff0c\u540c\u65f6\u51cf\u5c11\u6897\u585e\u9762\u79ef\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8111\u6c34\u80bf\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/brain-edema\">\u8111\u6c34\u80bf<\/a>\u3002\u4ece\u673a\u5236\u4e0a\u8bb2\uff0cHispidulin \u901a\u8fc7\u8c03\u8282 AMPK\/GSK3\u03b2 \u4fe1\u53f7\u901a\u8def\u6291\u5236 NLRP3 \u4ecb\u5bfc\u7684\u7ec6\u80de\u7126\u4ea1\uff0c\u5728\u4f53\u5185\u548c\u4f53\u5916\u53d1\u6325\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib214\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib214\"><span class=\"anchor-text\">[214]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0150\">\n<h4 id=\"sect0170\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.10.\u9ec4\u82aa\u7532\u82f7<\/h4>\n<p id=\"p0205\"><em><a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u9ec4\u82aa\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/astragalus-root\">\u9ec4\u82aa<\/a><\/em>\u00a0\u53ef\u8865\u865a\u635f\uff0c\u5065\u813e\u80c3\uff0c\u6d3b\u8840\u5316\u7600\uff0c\u6cbb\u7597\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6c14\u865a\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/qi-deficiency\">\u6c14\u865a<\/a>\u00a0\u548c\u8840\u865a\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib215\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib215\"><span class=\"anchor-text\">[215]<\/span><\/a>.\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u9ec4\u82aa\u7532\u82f7 IV \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/astragaloside-iv\">\u9ec4\u82aa\u7532\u82f7<\/a>\u00a0\u662f\u4e3b\u8981\u6d3b\u6027\u6210\u5206\u4e4b\u4e00\u00a0<em>\u9ec4\u82aa<\/em>\u00a0\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5355\u4f53\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/monomer\">\u5355\u4f53<\/a>\u00a0\u7684\u7ec4\u6210\u90e8\u5206\u00a0<a class=\"topic-link\" title=\"\u901a\u8fc7 ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u9ec4\u82aa\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/astragalus\">\u9ec4\u82aa<\/a>\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7682\u82f7\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/saponin\">\u7682\u7519<\/a>\u3002\u5e38\u4f5c\u4e3a\u68c0\u9a8c\u9ec4\u82aa\u8d28\u91cf\u7684\u6807\u51c6\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib216\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib216\"><span class=\"anchor-text\">[216]<\/span><\/a>\u3002\u9ec4\u82aa\u7532\u82f7IV\u5177\u6709\u591a\u79cd\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u751f\u7269\u6d3b\u52a8\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/biological-activity\">\u751f\u7269\u6d3b\u6027<\/a>\uff0c\u7814\u7a76\u8303\u56f4\u6d89\u53ca\u8111\u3001\u809d\u3001\u5fc3\u810f\u3001\u80ba\u3001\u80be\u3001\u80c3\u3001\u80a0\u3001\u8840\u7ba1\u7b49\u591a\u4e2a\u5668\u5b98\u548c\u7ec4\u7ec7\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib217\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib217\"><span class=\"anchor-text\">[217]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib218\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib218\"><span class=\"anchor-text\">[218]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib219\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib219\"><span class=\"anchor-text\">[219]<\/span><\/a>\u00a0\u5177\u6709\u6297\u708e\u3001\u6297\u75c5\u6bd2\u3001\u6297\u51cb\u4ea1\u3001\u4fc3\u8fdb\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7ec6\u80de\u589e\u6b96\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-proliferation\">\u7ec6\u80de\u589e\u6b96<\/a>\u3001\u8c03\u8282\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5154\u5b50\u75be\u75c5\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/rabbit-disease\">\u5154\u75c5<\/a>\u3001\u8c03\u8282\u8840\u7cd6\u3001\u5ef6\u7f13\u8870\u8001\u3001\u6291\u5236\u764c\u75c7\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib217\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib217\"><span class=\"anchor-text\">[217]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib218\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib218\"><span class=\"anchor-text\">[218]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib219\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib219\"><span class=\"anchor-text\">[219]<\/span><\/a>\u3002\u6211\u4eec\u4e4b\u524d\u7684\u7814\u7a76\u53d1\u73b0\u9ec4\u82aa\u7532\u82f7IV\u662f\u4e00\u79cd\u6f5c\u5728\u7684\u795e\u7ecf\u4fdd\u62a4\u5242\uff0c\u5728IS\u7684\u6cbb\u7597\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002\u4f8b\u5982\uff0c\u5b83\u53ef\u4ee5\u4fdd\u62a4\u8840\u8111\u5c4f\u969c\uff0c\u6539\u5584\u80fd\u91cf\u4ee3\u8c22\uff0c\u6291\u5236\u795e\u7ecf\u7ec6\u80de\u51cb\u4ea1\uff0c\u6291\u5236\u708e\u75c7\u53cd\u5e94\uff0c\u6c27\u5316\u5e94\u6fc0\uff0c\u53d1\u6325\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\uff0c\u4ece\u800c\u6539\u5584\u8111\u7f3a\u8840\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib220\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib220\"><span class=\"anchor-text\">[220]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib221\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib221\"><span class=\"anchor-text\">[221]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib222\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib222\"><span class=\"anchor-text\">[222]<\/span><\/a>\u5728\u7ec6\u80de\u7126\u4ea1\u65b9\u9762\uff0cTang\u7b49\u7814\u7a76\u53d1\u73b0\uff0cNLRP3\u708e\u75c7\u5c0f\u4f53\u5728\u5927\u9f20\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u8fc7\u7a0b\u4e2d\u88ab\u6fc0\u6d3b\uff0c\u6291\u5236NLRP3\u708e\u75c7\u5c0f\u4f53\u6216\u6291\u5236\u5176\u4e0b\u6e38\u7684Caspase-1\u53ef\u51cf\u8f7b\u5927\u9f20\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib223\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib223\"><span class=\"anchor-text\">[223]<\/span><\/a>\u3002\u9ec4\u82aa\u7532\u82f7\u53ef\u964d\u4f4e\u795e\u7ecf\u529f\u80fd\u7f3a\u635f\u8bc4\u5206\uff0c\u7f29\u5c0f\u8111\u6897\u585e\u4f53\u79ef\uff0c\u964d\u4f4e\u8111\u7ec4\u7ec7\u4e2dNLRP3\u3001Caspase-1\u3001pro-IL-1\u03b2\u3001IL-1\u03b2\u3001pro-IL-18\u3001IL-18\u86cb\u767d\u6c34\u5e73\uff0c\u5e76\u6291\u5236\u78f7\u9178\u5316NF-\u03baB\u86cb\u767d\u7684\u8868\u8fbe\u3002\u8fd9\u5c31\u8bf4\u660e\u9ec4\u82aa\u7532\u82f7\u5177\u6709\u6297 CIRI \u4f5c\u7528,\u5176\u673a\u5236\u53ef\u80fd\u4e0e\u6291\u5236 NF-\u03baB \u6709\u5173\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u86cb\u767d\u8d28\u78f7\u9178\u5316\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/protein-phosphorylation\">\u86cb\u767d\u8d28\u78f7\u9178\u5316<\/a>\u00a0\u4ee5\u53caNLRP3\u708e\u75c7\u5c0f\u4f53\u6fc0\u6d3b\u7684\u6291\u5236\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib223\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib223\"><span class=\"anchor-text\">[223]<\/span><\/a>\u674e\u7b49\u8fd8\u7814\u7a76\u53d1\u73b0\uff0c\u9ec4\u82aa\u7532\u82f7\u80fd\u51cf\u8f7b\u65b0\u751f\u5927\u9f20\u7f3a\u6c27\u7f3a\u8840\u6027\u8111\u635f\u4f24\uff0c\u6291\u5236\u65b0\u751f\u5927\u9f20\u7f3a\u6c27\u7f3a\u8840\u6027\u8111\u7ec4\u7ec7\u53caHT22\u6d77\u9a6c\u795e\u7ecf\u5143\u7684\u708e\u75c7\u53cd\u5e94\uff0c\u5176\u673a\u5236\u53ef\u80fd\u662f\u901a\u8fc7\u8c03\u63a7MMP-9\u4ecb\u5bfc\u7684NLRP3\/Caspase-1\u4fe1\u53f7\u901a\u8def\u5b9e\u73b0\u7684\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib224\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib224\"><span class=\"anchor-text\">[224]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0155\">\n<h4 id=\"sect0175\" class=\"u-margin-m-top u-margin-xs-bottom\">5.1.11. \u4e09\u4e03\u7682\u82f7\uff08PNS\uff09<\/h4>\n<p id=\"p0210\"><em>\u4e09\u4e03<\/em>\u00a0\u662f\u5e72\u71e5\u7684\u6839\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6839\u830e\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/rhizome\">\u6839\u830e<\/a>\u00a0\u7684\u00a0<em><a class=\"topic-link\" title=\"\u901a\u8fc7 ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u4eba\u53c2\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/panax\">\u4eba\u53c2<\/a><\/em><em>\u00a0\u4e09\u4e03\uff08Burk.\uff09<\/em>\u00a0FH Chen\uff0c\u5728\u8840\u6db2\u3001\u5fc3\u8840\u7ba1\u3001\u795e\u7ecf\u548c\u514d\u75ab\u7cfb\u7edf\u4e2d\u5177\u6709\u836f\u7406\u6d3b\u6027\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib225\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib225\"><span class=\"anchor-text\">[225]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib226\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib226\"><span class=\"anchor-text\">[226]<\/span><\/a>\u3002\u5176\u4e3b\u8981\u6709\u6548\u6210\u5206\u4e3a\u4e09\u4e03\u603b\u7682\u82f7\uff0c\u542b\u591a\u79cd\u5355\u4f53\u7682\u82f7\uff0c\u5176\u5236\u5242\u5982\u8840\u585e\u901a\u6ce8\u5c04\u6db2\u7b49\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u7684\u9632\u6cbb\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib227\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib227\"><span class=\"anchor-text\">[227]<\/span><\/a>\u3002\u6211\u4eec\u4e4b\u524d\u7684\u7814\u7a76\u548c\u73b0\u6709\u7684\u7814\u7a76\u8868\u660e\uff0c\u4e09\u4e03\u603b\u7682\u82f7\u5728\u7f3a\u8840\u6027\u8111\u635f\u4f24\u4e2d\u5177\u6709\u591a\u79cd\u836f\u7406\u4f5c\u7528\uff0c\u4f8b\u5982\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6297\u8840\u6813\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antithrombotic\">\u6297\u8840\u6813<\/a>\u3001\u6297\u708e\u3001\u6297\u6c27\u5316\u3001\u6291\u5236\u8111\u795e\u7ecf\u7ec6\u80de\u51cb\u4ea1\u3001\u6539\u5584\u8840\u8111\u5c4f\u969c\u635f\u4f24\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib228\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib228\"><span class=\"anchor-text\">[228]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib229\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib229\"><span class=\"anchor-text\">[229]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib230\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib230\"><span class=\"anchor-text\">[230]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib231\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib231\"><span class=\"anchor-text\">[231]<\/span><\/a>\u63d0\u793aPNS\u53ef\u80fd\u901a\u8fc7\u591a\u9776\u70b9\u53d1\u6325\u8111\u7f3a\u8840\u4fdd\u62a4\u4f5c\u7528\u3002\u8fd1\u671f\u7814\u7a76\u53d1\u73b0PNS\u80fd\u591f\u6291\u5236NLRP3\u708e\u75c7\u5c0f\u4f53\u7684\u6fc0\u6d3b\uff0c\u9009\u62e9\u6027\u4fc3\u8fdb\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7ebf\u7c92\u4f53\u81ea\u566c\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/mitophagy\">\u7ebf\u7c92\u4f53\u81ea\u566c<\/a>\u00a0\u6291\u5236\u7ebf\u7c92\u4f53\u81ea\u566c\u53ef\u9006\u8f6cPNS\u5bf9NLRP3\u708e\u75c7\u5c0f\u4f53\u7684\u6291\u5236\u4f5c\u7528\uff0c\u63d0\u793a\u7ebf\u7c92\u4f53\u81ea\u566c\u4ecb\u5bfcPNS\u6291\u5236\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u8fc7\u7a0b\u4e2dNLRP3\u708e\u75c7\u5c0f\u4f53\u6d3b\u5316\u7684\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u5927\u9f20\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u8fc7\u7a0b\u4e2d\u7ebf\u7c92\u4f53\u4e2dPINK1\u548cParkin\u86cb\u767d\u542b\u91cf\u5347\u9ad8\uff0c\u800cPNS\u53ef\u8fdb\u4e00\u6b65\u5347\u9ad8\u8111\u7ec4\u7ec7\u7ebf\u7c92\u4f53\u4e2dPINK1\u548cParkin\u86cb\u767d\u542b\u91cf\uff0c\u63d0\u793aPNS\u53ef\u80fd\u901a\u8fc7PINK1\/Parkin\u901a\u8def\u4fc3\u8fdb\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u8fc7\u7a0b\u4e2d\u7684\u7ebf\u7c92\u4f53\u81ea\u566c\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib232\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib232\"><span class=\"anchor-text\">[232]<\/span><\/a>\u7efc\u4e0a\u6240\u8ff0,PNS\u901a\u8fc7PINK1\/Parkin\u901a\u8def\u9009\u62e9\u6027\u4fc3\u8fdb\u7ebf\u7c92\u4f53\u81ea\u566c,\u6291\u5236\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u65f6NLRP3\u708e\u75c7\u5c0f\u4f53\u7684\u6fc0\u6d3b,\u51cf\u8f7b\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u3002<\/p>\n<\/section>\n<\/section>\n<section id=\"sec0160\">\n<h3 id=\"sect0180\" class=\"u-h4 u-margin-m-top u-margin-xs-bottom\">5.2.\u5929\u7136\u690d\u7269\u63d0\u53d6\u7269<\/h3>\n<section id=\"sec0165\">\n<h4 id=\"sect0185\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.1. \u6843\u7ea2\u56db\u7269\u6c64\uff08THSWD\uff09<\/h4>\n<p id=\"p0215\">\u6e05\u70ed\u89e3\u6bd2\u65b9\u662f\u6d3b\u8840\u5316\u7600\u7684\u7ecf\u5178\u65b9\u5242\u4e4b\u4e00\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8840\u7600\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/blood-stasis\">\u8840\u7600<\/a>\u6e05\u4ee3\u5434\u8c26\u300a\u533b\u5b97\u91d1\u9274\u300b\u4e2d\u5c31\u6709\u201c\u6d3b\u8840\u5316\u7600\uff0c\u751f\u65b0\u8840\u201d\u7684\u529f\u6548\u3002\u76ee\u524d\u836f\u7406\u7814\u7a76\u8bc1\u5b9e\uff0c\u5929\u9ebb\u7684\u4e3b\u8981\u6709\u6548\u6210\u5206\u5305\u62ec\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u963f\u9b4f\u9178\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ferulic-acid\">\u963f\u9b4f\u9178<\/a>,\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7ea2\u82b1\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/safflower\">\u7ea2\u82b1<\/a>\u00a0\u9ec4\u8272\uff0c\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u591a\u7cd6\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glycan\">\u591a\u7cd6<\/a>\u5176\u4e2d\u963f\u9b4f\u9178\u5177\u6709\u6291\u5236\u8840\u5c0f\u677f\u805a\u96c6\u3001\u6297\u8840\u6813\u3001\u6297\u708e\u3001\u6297\u6c27\u5316\u7b49\u836f\u7406\u4f5c\u7528\uff0c\u7ea2\u82b1\u9ec4\u8272\u7d20\u5177\u6709\u6297\u8111\u7f3a\u8840\u3001\u6297\u5fc3\u808c\u7f3a\u8840\u3001\u6297\u8840\u6813\u3001\u6297\u6c27\u5316\u3001\u6297\u80bf\u7624\u7b49\u4f5c\u7528\u3002\u5468\u7b49\u7814\u7a76\u53d1\u73b0\uff0c\u5929\u82b1\u6563\u80fd\u6539\u5584\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u540e\u7684\u795e\u7ecf\u529f\u80fd\u7f3a\u635f\u529f\u80fd\u3001\u8111\u6897\u6b7b\u4f53\u79ef\u53ca\u8111\u7ec4\u7ec7\u5f62\u6001\uff0c\u5e76\u660e\u663e\u964d\u4f4eDRP1\u3001NLRP3\u3001Caspase-1\u53caIL-1\u03b2\u86cb\u767d\u6c34\u5e73\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib233\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib233\"><span class=\"anchor-text\">[233]<\/span><\/a>\u63d0\u793a\u4e2d\u836f\u590d\u65b9\u5bf9\u8111\u6897\u6b7b\u7684\u6cbb\u7597\u4f5c\u7528\u4e0e\u6291\u5236\u7ec6\u80de\u7126\u4ea1\u76f8\u5173\u7684DRP1\/NLRP3\u901a\u8def\u6709\u5173\u3002\u8fdb\u4e00\u6b65\u7814\u7a76\u53d1\u73b0\uff0c\u4e2d\u836f\u590d\u65b9\u6cbb\u7597\u540e\uff0cIL-1\u03b2\u3001IL-18\u542b\u91cf\u660e\u663e\u964d\u4f4e\uff0cNLRP3\u3001Caspase-1\u3001Caspase-1 p10\u3001ASC\u3001TXNIP\u3001GSDMD\u542b\u91cf\u964d\u4f4e\u3002\u4fe1\u53f7\u901a\u8def\u68c0\u6d4b\u663e\u793a\uff0c\u4e2d\u836f\u590d\u65b9\u6cbb\u7597\u540e\uff0cHMGB1\/RAGE\u3001TLR4\/NF-\u03baB\u3001\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 p38 MAPK \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/p38-mitogen-activated-protein-kinase\">p38MAPK<\/a>\u00a0\u7efc\u4e0a\u6240\u8ff0\uff0cTHSWD\u53ef\u964d\u4f4eMCAO\/R\u5927\u9f20\u7684\u708e\u75c7\u53cd\u5e94\u6c34\u5e73\uff0c\u6291\u5236NLRP3\u708e\u75c7\u5c0f\u4f53\u7684\u6fc0\u6d3b\uff0c\u4e0b\u8c03GSDMD\u3002THSWD\u5177\u6709\u6291\u5236\u7ec6\u80de\u7126\u4ea1\u7684\u4f5c\u7528\uff0c\u5176\u673a\u5236\u53ef\u80fd\u4e0e\u6291\u5236HMGB1\/TLR4\/NF-kB\u53caMAPK\u4fe1\u53f7\u901a\u8def\u6709\u5173\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib234\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib234\"><span class=\"anchor-text\">[234]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0170\">\n<h4 id=\"sect0190\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.2. \u8111\u5fc3\u6e05\u80f6\u56ca\uff08NXQC\uff09<\/h4>\n<p id=\"p0220\">NXQC\u7684\u4e3b\u8981\u6210\u5206\u662f\u00a0<em><a class=\"topic-link\" title=\"\u901a\u8fc7 ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u67ff\u5b50\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/persimmon\">\u67ff<\/a><\/em>\u00a0Thunb\uff08\u67ff\u5b50\u53f6\uff09\u3002\u7814\u7a76\u8868\u660e\uff0c\u67ff\u53f6\u63d0\u53d6\u7269\u542b\u6709\u9ec4\u916e\u7c7b\u5316\u5408\u7269\u3001\u6709\u673a\u9178\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u9999\u8c46\u7d20\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/coumarin\">\u9999\u8c46\u7d20<\/a>\u00a0\u7b49\u5316\u5b66\u7269\u8d28\uff0c\u5177\u6709\u6297\u708e\u3001\u6297\u6c27\u5316\u3001\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6297\u9ad8\u8840\u538b\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/antihypertensive-agent\">\u6297\u9ad8\u8840\u538b<\/a>\u3001\u964d\u8840\u8102\u3001\u6539\u5584\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8840\u7ba1\u5e73\u6ed1\u808c\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vascular-smooth-muscle\">\u8840\u7ba1\u5e73\u6ed1\u808c<\/a>\u00a0\u529f\u80fd\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8840\u6d41\u52a8\u529b\u5b66\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/hemodynamic\">\u8840\u6d41\u52a8\u529b\u5b66<\/a>\u00a0\u529f\u80fd\u3002\u8be5\u836f\u5df2\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u7684\u6cbb\u7597\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib235\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib235\"><span class=\"anchor-text\">[235]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib236\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib236\"><span class=\"anchor-text\">[236]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib237\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib237\"><span class=\"anchor-text\">[237]<\/span><\/a>. \u73b0\u6709\u7814\u7a76\u8868\u660e NXQC \u53ef\u4ee5\u6709\u6548\u63d0\u9ad8\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8111\u52a8\u8109\u786c\u5316\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cerebral-atherosclerosis\">\u8111\u52a8\u8109\u786c\u5316<\/a>\u00a0\u4fdd\u62a4\u56e0\u8111\u7f3a\u8840\u5f15\u8d77\u7684\u795e\u7ecf\u635f\u4f24\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib238\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib238\"><span class=\"anchor-text\">[238]<\/span><\/a>\u3002\u654f\u7b49\u4eba\u3002\u7814\u7a76\u53d1\u73b0NXQC\u53ef\u4ee5\u6709\u6548\u6539\u5584\u8111\u7f3a\u8840\u540e\u5b66\u4e60\u80fd\u529b\u7684\u4e0b\u964d\uff0c\u589e\u52a0\u5927\u8111\u7684\u6d3b\u52a8\u80fd\u529b\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8d85\u6c27\u5316\u7269\u6b67\u5316\u9176\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/superoxide-dismutase\">\u8d85\u6c27\u5316\u7269\u6b67\u5316\u9176<\/a>\u00a0\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u4e73\u9178\u8131\u6c22\u9176\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/lactate-dehydrogenase\">\u4e73\u9178\u8131\u6c22\u9176<\/a>\uff0c\u589e\u52a0GSH\u542b\u91cf\uff0c\u51cf\u5c11\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u4e19\u4e8c\u919b\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/malonaldehyde\">\u4e19\u4e8c\u919b<\/a>\u3002 NXQC\u8fd8\u53ef\u4e0b\u8c03\u6d77\u9a6c\u4e2dASC\u3001NLRP3\u548cCaspase-1\u86cb\u767d\uff0c\u5e76\u663e\u7740\u964d\u4f4eIL-18\u548cIL-1\u03b2\u542b\u91cf\u3002\u4ed6\u4eec\u8fd8\u53d1\u73b0\uff0c\u7ecf\u8fc7NXQC\u5e72\u9884\u540e\uff0c\u6c99\u9f20\u4f53\u5185\u7684\u8840\u5c0f\u677f\u5185\u76ae\u7ec6\u80de\u7c98\u9644\u5206\u5b501\u9633\u6027\u7ec6\u80de\u663e\u7740\u589e\u52a0\uff0c\u5e76\u4e14\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7ec6\u80de\u95f4\u8fde\u63a5\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/cell-junction\">\u7ec6\u80de\u95f4\u8fde\u63a5<\/a>\u00a0\u8868\u660e NXQC \u53ef\u4ee5\u6709\u6548\u4fdd\u62a4\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6d77\u9a6c CA1 \u533a\u57df\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/sommers-sector\">\u6d77\u9a6cCA1\u533a<\/a>\u00a0\u6c99\u9f20\u7684\u4f5c\u7528\uff0c\u4fdd\u62a4\u8111\u8840\u7ba1\u529f\u80fd\uff0c\u8fdb\u800c\u6291\u5236\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib239\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib239\"><span class=\"anchor-text\">[239]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0175\">\n<h4 id=\"sect0195\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.3.\u8865\u9633\u8fd8\u4e94\u6c64\u53ca\u5176\u52a0\u51cf<\/h4>\n<p id=\"p0225\">BYHWD \u662f\u8457\u540d\u7684\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u4f20\u7edf\u4e2d\u533b\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/traditional-chinese-medicine\">\u4e2d\u836f<\/a>\u00a0\u7528\u4e8e\u6cbb\u7597\u4e2d\u98ce\u7684\u914d\u65b9\u3002\u5176\u65b9\u5242\u6700\u65e9\u8bb0\u8f7d\u4e8e\u6e05\u4ee3\u738b\u5e86\u4efb\u7684\u300a\u533b\u7ecf\u6821\u6b63\u300b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib240\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib240\"><span class=\"anchor-text\">[240]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib241\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib241\"><span class=\"anchor-text\">[241]<\/span><\/a>\u3002\u662f\u76ca\u6c14\u6d3b\u8840\u65b9\u7684\u6770\u51fa\u4ee3\u8868\u3002\u5177\u6709\u8865\u6c14\u3001\u6d3b\u8840\u3001\u901a\u7edc\u7684\u4f5c\u7528\u3002\u5176\u5faa\u8bc1\u533b\u5b66\u7814\u7a76\u663e\u793a\u51fa\u826f\u597d\u7684\u4e34\u5e8a\u6548\u679c\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib242\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib242\"><span class=\"anchor-text\">[242]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib243\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib243\"><span class=\"anchor-text\">[243]<\/span><\/a>\u3002\u6211\u4eec\u4e4b\u524d\u7684\u7814\u7a76\u8868\u660e BYHWD\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7cd6\u82f7\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glycoside\">\u7519\u7c7b<\/a>\u00a0\u53ef\u6539\u5584\u795e\u7ecf\u529f\u80fd\u969c\u788d\uff0c\u51cf\u8f7b\u795e\u7ecf\u5143\u635f\u4f24\uff0c\u6291\u5236\u795e\u7ecf\u5143\u7126\u4ea1\u3002\u8865\u9633\u8fd8\u4e94\u6c64\u82f7\u662f\u4ece\u8865\u9633\u8fd8\u4e94\u6c64\u4e2d\u63d0\u53d6\u7684\u6709\u6548\u6210\u5206\uff0c\u4e3b\u8981\u5305\u62ec\u9ec4\u82aa\u7532\u82f7\u3001\u828d\u836f\u82f7\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u82e6\u674f\u4ec1\u82f7\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/amygdalin\">\u82e6\u674f\u4ec1\u7519<\/a>.\u662f\u8865\u80be\u6d3b\u8840\u7684\u4e3b\u8981\u836f\u7406\u6d3b\u6027\u6210\u5206\uff0c\u53ef\u6cbb\u7597\u8111\u7f3a\u8840\u6027\u795e\u7ecf\u635f\u4f24\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib244\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib244\"><span class=\"anchor-text\">[244]<\/span><\/a>\u3002\u6b64\u5916\uff0c\u6211\u4eec\u89c2\u5bdf\u5230\u8865\u9633\u8fd8\u4e94\u6c64\u82f7\u663e\u7740\u6291\u5236NLRP3\u4ecb\u5bfc\u7684\u7ecf\u5178\u7ec6\u80de\u7126\u4ea1\u9014\u5f84\u7684NLRP3\u3001ASC\u3001pro-caspase-1\u3001caspase-1\u548cIL-1\u03b2\u86cb\u767d\u7684\u8868\u8fbe\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib209\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib209\"><span class=\"anchor-text\">[209]<\/span><\/a>\u3002\u7efc\u4e0a\u6240\u8ff0\uff0c\u8865\u9633\u8fd8\u4e94\u6c64\u82f7\u901a\u8fc7\u6291\u5236CIRI\u540e\u795e\u7ecf\u5143\u7126\u4ea1\u53d1\u6325\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\uff0c\u8fd9\u4e0eNLRP3\u5bf9\u7ecf\u5178\u7126\u4ea1\u901a\u8def\u7684\u8c03\u8282\u5bc6\u5207\u76f8\u5173\u3002\u6b64\u5916\uff0c\u9f99\u667a\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6c64\u5242\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/decoction\">\u6c64<\/a>\u00a0\u662f BYHWD \u4e0e\u6c34\u86ed\u5f62\u6210\u7684\u7ecf\u9a8c\u516c\u5f0f\u00a0<a class=\"topic-link\" title=\"\u901a\u8fc7 ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u725b\u819d\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/achyranthes\">\u725b\u819d<\/a>\u00a0\u5ddd\u828e\uff0c\u4e34\u5e8a\u7528\u4e8e\u6cbb\u7597\u6025\u6027\u4e2d\u98ce\u591a\u5e74\uff0c\u6548\u679c\u5f88\u597d\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib245\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib245\"><span class=\"anchor-text\">[245]<\/span><\/a>\u8fd1\u671f\u7814\u7a76\u8868\u660e\uff0c\u9f99\u679d\u6c64\u5bf9\u6539\u5584\u5927\u9f20CIRI\u540e\u795e\u7ecf\u7cfb\u7edf\u75c7\u72b6\u3001\u7ef4\u6301\u8111\u7ec4\u7ec7\u795e\u7ecf\u7ec6\u80de\u72b6\u6001\u3001\u51cf\u5c11\u8111\u6897\u6b7b\u4f53\u79ef\u6709\u660e\u663e\u4f5c\u7528\u3002\u5728\u5e72\u9884\u7ec6\u80de\u7126\u4ea1\u65b9\u9762\uff0c\u9f99\u679d\u6c64\u80fd\u6539\u5584\u5927\u9f20CIRI\u540e\u75c7\u72b6\uff0c\u4fdd\u62a4\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u795e\u7ecf\u7ec6\u80de\u635f\u4f24\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nerve-cell-lesion\">\u795e\u7ecf\u7ec6\u80de\u635f\u4f24<\/a>\u00a0\u635f\u4f24\u540e\u901a\u8fc7\u4e0b\u8c03 Caspase-1 \u548c IL-18 \u86cb\u767d\u7684\u8868\u8fbe\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib245\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib245\"><span class=\"anchor-text\">[245]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0180\">\n<h4 id=\"sect0200\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.4.\u76ca\u6c14\u6d3b\u8840\u65b9<\/h4>\n<p id=\"p0230\">YQHXP \u5305\u542b\u00a0<em>\u5f53\u5f52\u3001\u9ec4\u82aa\u3001\u00a0<\/em><em><a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5ddd\u828e\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/ligusticum-chuanxiong-extract\">\u5ddd\u828e<\/a><\/em><em>\u3001\u5168\u874e\u3001\u76ca\u6bcd\u8349\u3001\u77f3\u83d6\u84b2\u3001\u51b0\u7247<\/em>\u5e76\u53d6\u5f97\u4e86\u826f\u597d\u7684\u4e34\u5e8a\u6548\u679c\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib246\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib246\"><span class=\"anchor-text\">[246]<\/span><\/a>\u3002\u52a8\u7269\u7814\u7a76\u8868\u660e\uff0c\u76ca\u6c14\u6d3b\u8840\u65b9\u53ef\u6539\u5584\u5927\u9f20\u795e\u7ecf\u529f\u80fd\u8bc4\u5206\u548c\u8111\u6897\u585e\u53d1\u751f\u7387\uff0c\u5e76\u964d\u4f4e\u8111\u7ec4\u7ec7\u4e2dIL-1\u03b2\u3001TNF-\u03b1\u3001IL-18\u7684\u6c34\u5e73\uff0c\u964d\u4f4e\u8111\u7ec4\u7ec7\u4e2dIL-1\u03b2\u3001TNF-\u03b1\u3001IL-18\u7684\u6c34\u5e73\u4ee5\u53ca\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 P2RX7 \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/p2rx7\">P2RX7<\/a>\u3001Caspase-1\u3001Caspase-11\u3001GSDMD\u5728\u8111\u7f3a\u8840\u534a\u6697\u5e26\u7ec4\u7ec7\u4e2d\u7684\u8868\u8fbe\u5747\u663e\u8457\u964d\u4f4e\u3002\u76ca\u6c14\u6d3b\u8840\u6563\u5e72\u9884\u540e\uff0c\u8111\u7ec4\u7ec7\u708e\u6027\u6e17\u51fa\u3001\u6c34\u80bf\u660e\u663e\u51cf\u8f7b\uff0c\u7ec6\u80de\u5f62\u6001\u53ca\u795e\u7ecf\u5143\u7a7a\u6ce1\u53d8\u6027\u6539\u5584\u3002\u7efc\u4e0a\u6240\u8ff0\uff0c\u76ca\u6c14\u6d3b\u8840\u6563\u53ef\u80fd\u901a\u8fc7\u6291\u5236\u7ec6\u80de\u7126\u4ea1\u6765\u51cf\u8f7b\u6025\u6027\u7f3a\u8840\u6027\u5352\u4e2d\u5927\u9f20\u8111\u7ec4\u7ec7\u708e\u75c7\u53cd\u5e94\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib247\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib247\"><span class=\"anchor-text\">[247]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0185\">\n<h4 id=\"sect0205\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.5. \u80be\u8111\u590d\u5143\u6c64\uff08SNFYD\uff09<\/h4>\n<p id=\"p0235\">SNFYD\u662f\u57fa\u4e8e\u80be\u8111\u540c\u6cbb\u7406\u8bba\u7684\u6cbb\u7597\u7f3a\u8840\u6027\u4e2d\u98ce\u7684\u6709\u6548\u65b9\u5242\u3002\u5176\u7ec4\u6210\u4e3a\uff1a\u00a0<em>\u9ec4\u82aa<\/em>\u00a030\u514b<em>,\u00a0<\/em><em><a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5730\u9ec4\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/rehmannia\">\u5730\u9ec4<\/a><\/em><em>\u00a0\u7099\u7518\u8349<\/em>\u00a010\u514b<em>\u5c71\u8331\u8438<\/em>\u00a010\u514b<em>\u5c71\u836f<\/em>\u00a015 \u514b<em>, \u7ea2\u666f\u5929<\/em>\u00a020 \u514b<em>,\u00a0<\/em><em><a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684\u4eba\u5de5\u667a\u80fd\u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7261\u4e39\u76ae\u5c42\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/moutan-cortex\">\u7261\u4e39\u76ae<\/a><\/em>\u00a010\u514b<em>, \u5f53\u5f52<\/em>\u00a010\u514b<em>, \u8d64\u828d<\/em>\u00a010\u514b<em>,\u00a0<\/em><em><a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 Pheredima \u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/pheretima\">\u5730\u9f99\u5c5e<\/a><\/em>\u00a010\u514b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib248\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib248\"><span class=\"anchor-text\">[248]<\/span><\/a>\u3002\u914d\u4ee5\u5927\u91cf\u8865\u6c14\u3001\u8865\u7cbe\u3001\u8865\u80be\u836f\u7269\uff0c\u4e0e\u6d3b\u8840\u901a\u7edc\u76f8\u7ed3\u5408\u3002\u7814\u7a76\u8868\u660e\uff0cOGD\u9020\u6a21\u540e\uff0cPC12\u663e\u7740\u53d7\u635f\uff0c\u7ec6\u80de\u7126\u4ea1\u9014\u5f84\u4e2d\u7684\u591a\u79cd\u7ec6\u80de\u56e0\u5b50\u663e\u7740\u589e\u52a0\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib249\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib249\"><span class=\"anchor-text\">[249]<\/span><\/a>. \u542bSNFYD\u8840\u6e05\u548cINF39\u5e72\u9884\u53d7\u635f\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173 PC12 \u7ec6\u80de\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pc12-cell-line\">PC12\u7ec6\u80de<\/a>\u540ePC12\u7ec6\u80de\u5f62\u6001\u53ca\u6d3b\u6027\u5f97\u5230\u6539\u5584,NLRP3\/Caspase-1\u7ec6\u80de\u7126\u4ea1\u901a\u8def\u7684\u6fc0\u6d3b\u76f8\u5e94\u51cf\u5f31,\u63d0\u793a\u8be5\u901a\u8def\u7684\u6291\u5236\u4e0e\u7ec6\u80de\u72b6\u6001\u6539\u5584\u6709\u5173,\u800cSNFYD\u53caINF39\u5747\u80fd\u6291\u5236\u8be5\u901a\u8def\u7684\u6fc0\u6d3b,\u63d0\u793aSNFYD\u53ef\u80fd\u901a\u8fc7\u6291\u5236NLRP3\/Caspase-1\u53ca\u4e0b\u6e38\u7ec6\u80de\u7126\u4ea1\u901a\u8def,\u51cf\u8f7b\u795e\u7ecf\u7ec6\u80de\u708e\u6027\u51cb\u4ea1,\u4ece\u800c\u4fdd\u62a4\u795e\u7ecf\u7ec4\u7ec7,\u8fbe\u5230\u6cbb\u7597\u8111\u6897\u6b7b\u7684\u76ee\u7684\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib250\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib250\"><span class=\"anchor-text\">[250]<\/span><\/a>.<\/p>\n<\/section>\n<section id=\"sec0190\">\n<h4 id=\"sect0210\" class=\"u-margin-m-top u-margin-xs-bottom\">5.2.6\u3002\u5176\u4ed6\u63d0\u53d6\u7269<\/h4>\n<p id=\"p0240\">\u6b64\u5916\uff0c\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0c\u809d\u7d20\u7b49\u6297\u8840\u6813\u836f\u7269\u53ef\u4ee5\u901a\u8fc7\u6291\u5236\u7126\u4ea1\u6765\u6539\u5584\u80ba\u635f\u4f24\u3002\u4f8b\u5982\uff0c\u6768\u7b49\u4eba\u3002\u53d1\u73b0\u809d\u7d20\u901a\u8fc7\u963b\u65ad hMGB1 LPS \u8bf1\u5bfc\u7684 caspase-11 \u6fc0\u6d3b\u6765\u6291\u5236\u80ba\u5185\u76ae\u7ec6\u80de\u51cb\u4ea1\uff0c\u8fd9\u53ef\u80fd\u662f\u6cbb\u7597\u8113\u6bd2\u75c7\u5f15\u8d77\u7684\u80ba\u635f\u4f24\u7684\u6f5c\u5728\u65b9\u6cd5\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib251\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib251\"><span class=\"anchor-text\">[251]<\/span><\/a>Prathapan \u7b49\u4eba\u53d1\u73b0\uff0c\u5ae9\u6930\u5b50\u6c34\u5177\u6709\u6297\u6c27\u5316\u548c\u6297\u8840\u6813\u4f5c\u7528\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u5b9e\u9a8c\u6027\u5fc3\u808c\u6897\u6b7b\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/experimental-myocardial-infarction\">\u5b9e\u9a8c\u6027\u5fc3\u808c\u6897\u6b7b<\/a>\u00a0\u6a21\u578b\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib252\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib252\"><span class=\"anchor-text\">[252]<\/span><\/a>\uff0c\u800c\u5e74\u8f7b\u7684\u6930\u5b50\u6c41\u53ef\u4ee5\u663e\u7740\u51cf\u5c11\u4e0e\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/alzheimer-disease\">\u963f\u5c14\u8328\u6d77\u9ed8\u6c0f\u75c5<\/a>\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib253\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib253\"><span class=\"anchor-text\">[253]<\/span><\/a>\u3002\u8fd9\u8868\u660e\u6930\u5b50\u6c34\u53ef\u80fd\u662f\u4e00\u79cd\u6f5c\u5728\u7684\u7126\u4ea1\u6291\u5236\u5242\uff0c\u672a\u6765\u53ef\u80fd\u4f1a\u7814\u7a76\u5176\u5728IS\u4e2d\u8c03\u8282\u7126\u4ea1\u7684\u4f5c\u7528\u3002<\/p>\n<p id=\"p0245\"><span class=\"small-caps\">L<\/span>-\u7cbe\u6c28\u9178\u662f\u4e00\u79cd\u6709\u673a\u5316\u5408\u7269\uff0c\u5b58\u5728\u4e8e\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u9c7c\u7cbe\u86cb\u767d\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/protamine\">\u9c7c\u7cbe\u86cb\u767d<\/a>\u00a0\u5927\u91cf\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib254\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib254\"><span class=\"anchor-text\">[254]<\/span><\/a>\u3002\u5b83\u662f\u5408\u6210\u7684\u524d\u4f53\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u4e00\u6c27\u5316\u6c2e\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nitric-oxide\">\u4e00\u6c27\u5316\u6c2e<\/a>\u00a0(NO)\uff0c\u4fdd\u62a4\u5b8c\u6574\u7684\u8840\u7ba1\u5185\u76ae\uff0c\u5145\u5f53\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u8840\u7ba1\u6269\u5f20\u5242\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/vasodilator-agent\">\u8840\u7ba1\u6269\u5f20\u5242<\/a>\u00a0\u4ee5\u53ca\u5185\u6e90\u6027\u6297\u52a8\u8109\u7ca5\u6837\u786c\u5316\u5206\u5b50\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib254\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib254\"><span class=\"anchor-text\">[254]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib255\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib255\"><span class=\"anchor-text\">[255]<\/span><\/a>\u3002\u52a8\u7269\u5b9e\u9a8c\u8868\u660e\u00a0<span class=\"small-caps\">L<\/span>-\u7cbe\u6c28\u9178\u53ef\u80fd\u5177\u6709\u590d\u6742\u7684\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6297\u51dd\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/anticoagulation\">\u6297\u51dd<\/a>\u3001\u6297\u51dd\u548c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u7ea4\u7ef4\u86cb\u767d\u6eb6\u89e3\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/fibrinolysis\">\u7ea4\u7ef4\u86cb\u767d\u6eb6\u89e3<\/a>\u00a0\u6548\u679c\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib255\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib255\"><span class=\"anchor-text\">[255]<\/span><\/a>,\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib256\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib256\"><span class=\"anchor-text\">[256]<\/span><\/a>\u5728\u9ad8\u8840\u538b\u5927\u9f20\u4e2d\uff0cCylwik \u7b49\u4eba\u53d1\u73b0\u00a0<span class=\"small-caps\">L<\/span>\u03b1-\u7cbe\u6c28\u9178\u80fd\u964d\u4f4e\u5927\u9f20\u8840\u538b\uff0c\u957f\u671f\u670d\u7528\u80fd\u7f29\u77ed\u4f18\u7403\u86cb\u767d\u51dd\u5757\u6eb6\u89e3\u65f6\u95f4\u548c\u51fa\u8840\u65f6\u95f4\uff0c\u5e76\u53ef\u6291\u5236\u80f6\u539f\u8bf1\u5bfc\u7684\u8840\u5c0f\u677f\u805a\u96c6\u3002\u63d0\u793a\u00a0<span class=\"small-caps\">L<\/span>-\u7cbe\u6c28\u9178\u5728\u9ad8\u8840\u538b\u5927\u9f20\u6a21\u578b\u4e2d\u53d1\u6325\u6297\u8840\u6813\u4f5c\u7528\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u9759\u8109\u8840\u6813\u5f62\u6210\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/phlebothrombosis\">\u9759\u8109\u8840\u6813\u5f62\u6210<\/a>\u00a0\u4ee5\u590d\u6742\u7684\u65b9\u5f0f\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib256\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib256\"><span class=\"anchor-text\">[256]<\/span><\/a>. \u6700\u8fd1\u7684\u4e00\u9879\u7814\u7a76\u8868\u660e\u00a0<span class=\"small-caps\">L<\/span>-\u7cbe\u6c28\u9178\u53ef\u80fd\u662f\u7ec6\u80de\u7126\u4ea1\u7684\u6f5c\u5728\u6291\u5236\u5242\uff1aTanuseputero \u7b49\u4eba\u3002\u5efa\u8bae\u00a0<span class=\"small-caps\">L<\/span>-\u7cbe\u6c28\u9178\u53ef\u80fd\u90e8\u5206\u6291\u5236 NLRP3 \u708e\u75c7\u5c0f\u4f53\uff0c\u4ee5\u51cf\u8f7b\u8113\u6bd2\u75c7\u5f15\u8d77\u7684\u75c7\u72b6\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u6025\u6027\u80be\u635f\u4f24\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/acute-kidney-injury\">\u6025\u6027\u80be\u635f\u4f24<\/a>\u00a0\u5728\u5c0f\u9f20\u4e2d\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib257\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib257\"><span class=\"anchor-text\">[257]<\/span><\/a>\u3002\u9274\u4e8e\u5176\u8212\u8840\u7ba1\u3001\u6297\u8840\u6813\u548c\u6291\u5236NLRP3\u708e\u75c7\u5c0f\u4f53\u6d3b\u6027\u00a0<span class=\"small-caps\">L<\/span>-\u7cbe\u6c28\u9178\uff0c\u5efa\u8bae\u00a0<span class=\"small-caps\">L<\/span>-\u7cbe\u6c28\u9178\u53ef\u80fd\u5177\u6709\u589e\u52a0\u7f3a\u8840\u533a\u57df\u8840\u6d41\u91cf\u5e76\u6291\u5236 IS \u7126\u4ea1\u7684\u6f5c\u529b\u3002<\/p>\n<div>\n<p id=\"p0250\">\u8c03\u8282\u7ec6\u80de\u7126\u4ea1\u7684\u5929\u7136\u4ea7\u7269\u603b\u7ed3\u89c1\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#tbl0010\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"tbl0010\"><span class=\"anchor-text\">\u88682<\/span><\/a>.<\/p>\n<div id=\"tbl0010\" class=\"tables colsep-0 rowsep-0 frame-topbot\">\n<p id=\"sp0025\"><span class=\"label\">\u88682<\/span>. \u8c03\u63a7\u7ec6\u80de\u7126\u4ea1\u7684\u5929\u7136\u5316\u5408\u7269\u6982\u8ff0\u3002<\/p>\n<div class=\"groups\">\n<table>\n<thead>\n<tr class=\"rowsep-1\">\n<th scope=\"col\">\u5929\u7136\u4ea7\u7269<\/th>\n<th scope=\"col\">\u578b\u53f7\/\u75be\u75c5<\/th>\n<th scope=\"col\">\u7269\u79cd<\/th>\n<th scope=\"col\">\u6548\u679c<\/th>\n<th scope=\"col\">\u53c2\u8003<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<th scope=\"row\">\u5929\u9ebb\u7d20<\/th>\n<td>\u5927\u8111\u4e2d\u52a8\u8109\u95ed\u585e\/\u518d\u704c\u6ce8 (MCAO\/R)\u3001\u7f3a\u6c27\/\u590d\u6c27 (OGD\/R)<\/td>\n<td>\u8910\u5bb6\u9f20\u548c\u6765\u81ea\u8910\u5bb6\u9f20\u7684\u521d\u7ea7\u76ae\u8d28\u795e\u7ecf\u5143<\/td>\n<td>\u901a\u8fc7\u4e0b\u8c03 NLRP3\u3001\u708e\u75c7\u56e0\u5b50 (IL-1\u03b2\u3001IL-18) \u548c\u88c2\u89e3 caspase-1 \u6765\u6291\u5236\u7ec6\u80de\u7126\u4ea1\uff1b\u8c03\u8282 lncRNA NEAT1\/miR-22\u20133p \u8f74\u548c lncRNA NEAT1\/miR-22\u20133p \u8f74<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib204\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib204\"><span class=\"anchor-text\">[204]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u4e39\u53c2\u916eIIA<\/th>\n<td>\u7f3a\u6c27\/\u518d\u704c\u6ce8<\/td>\n<td>BV2 \u7ec6\u80de\uff08\u6765\u81ea\u5c0f\u5bb6\u9f20\u7684\u5c0f\u80f6\u8d28\u7ec6\u80de\uff09<\/td>\n<td>\u964d\u4f4e NLRP3 \u708e\u75c7\u4fe1\u53f7\u901a\u8def\u4e2d IL-1\u03b2 \u548c IL-18 \u7684\u8868\u8fbe<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib205\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib205\"><span class=\"anchor-text\">[205]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u76ca\u6bcd\u8349\u78b1<\/th>\n<td>MCAO<\/td>\n<td>\u8910\u5bb6\u9f20<\/td>\n<td>\u964d\u4f4e NLRP3 \u7684\u8868\u8fbe<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib206\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib206\"><span class=\"anchor-text\">[206]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u828d\u836f\u7519<\/th>\n<td>MCAO<\/td>\n<td>\u8910\u5bb6\u9f20<\/td>\n<td>\u6291\u5236 NLRP3\u3001Caspase-1 \u548c IL-1\u03b2 \u6c34\u5e73<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib209\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib209\"><span class=\"anchor-text\">[209]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u4e01\u57fa\u82ef\u915e<\/th>\n<td>MCAO<\/td>\n<td>\u8910\u5bb6\u9f20<\/td>\n<td>\u8c03\u8282 NLRP3 \u708e\u75c7\u5c0f\u4f53\u4fe1\u53f7\u901a\u8def<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib210\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib210\"><span class=\"anchor-text\">[210]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u706f\u76cf\u82b1\u7d20<\/th>\n<td>\u4e2d\u8111\u7f3a\u8840\/\u518d\u704c\u6ce8<\/td>\n<td>\u8910\u5bb6\u9f20<\/td>\n<td>\u6291\u5236CCI\u5927\u9f20\u6d77\u9a6cNLRP3\u708e\u75c7\u7ec6\u80de\u7684\u6d3b\u5316\uff0c\u4e0b\u8c03Caspase 1\u3001IL-6\u3001IL-1\u03b2\u86cb\u767d\u7684\u8868\u8fbe\uff0c\u6291\u5236Caspase-3\u86cb\u767d\u7684\u6d3b\u5316<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib211\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib211\"><span class=\"anchor-text\">[211]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u767d\u85dc\u82a6\u9187<\/th>\n<td>\u4e2d\u8111\u7f3a\u8840\/\u518d\u704c\u6ce8<\/td>\n<td>\u8910\u5bb6\u9f20<\/td>\n<td>\u8c03\u8282\u5c0f\u80f6\u8d28\u7ec6\u80de NLRP3 \u708e\u6027\u4f53\u3001Caspase-1 \u548c ZO-1<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib212\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib212\"><span class=\"anchor-text\">[212]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u4e39\u915a\u9178<\/th>\n<td>MCAO\/R \u548c OGD\/R<\/td>\n<td>\u8910\u5bb6\u9f20\u548c\u6765\u81ea\u8910\u5bb6\u9f20\u7684\u5c0f\u80f6\u8d28\u7ec6\u80de<\/td>\n<td>\u6291\u5236 NLRP3 \u708e\u75c7\u5c0f\u4f53\u7684\u6fc0\u6d3b\u4ee5\u53ca NLRP3 \u708e\u75c7\u5c0f\u4f53\/\u70ed\u6c27\u76f8\u5173\u86cb\u767d\u7684\u8868\u8fbe<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib213\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib213\"><span class=\"anchor-text\">[213]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u7ec4\u86cb\u767d<\/th>\n<td>MCAO<\/td>\n<td>\u8910\u5bb6\u9f20<\/td>\n<td>\u901a\u8fc7\u8c03\u8282 AMPK\/GSK3\u03b2 \u4fe1\u53f7\u901a\u8def\u6291\u5236 NLRP3 \u4ecb\u5bfc\u7684\u7ec6\u80de\u7126\u4ea1<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib214\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib214\"><span class=\"anchor-text\">[214]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u9ec4\u82aa\u7532\u82f7<\/th>\n<td>\u4e2d\u8111\u7f3a\u8840\/\u518d\u704c\u6ce8<\/td>\n<td>\u8910\u5bb6\u9f20<\/td>\n<td>\u6291\u5236NLRP3\u708e\u75c7\u5c0f\u4f53\u7684\u6fc0\u6d3b\uff0c\u964d\u4f4e\u8111\u7ec4\u7ec7\u4e2dNLRP3\u3001Caspase-1\u3001pro-IL-1\u03b2\u3001IL-1\u03b2\u3001pro-IL-18\u3001IL-18\u7684\u86cb\u767d\u6c34\u5e73\uff0c\u6291\u5236\u78f7\u9178\u5316NF-\u03baB\u86cb\u767d\u7684\u8868\u8fbe<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib223\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib223\"><span class=\"anchor-text\">[223]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u4e09\u4e03\u603b\u7682\u82f7<\/th>\n<td>\u4e2d\u8111\u7f3a\u8840\/\u518d\u704c\u6ce8<\/td>\n<td>\u8910\u5bb6\u9f20<\/td>\n<td>\u8c03\u8282 PINK1\/Parkin \u901a\u8def\uff1b\u6291\u5236 NLRP3 \u708e\u75c7\u5c0f\u4f53\u7684\u6fc0\u6d3b<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib232\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib232\"><span class=\"anchor-text\">[232]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u6843\u7ea2\u56db\u7269\u6c64<\/th>\n<td>MCAO<\/td>\n<td>\u8910\u5bb6\u9f20<\/td>\n<td>\u964d\u4f4e DRP1\u3001NLRP3\u3001Caspase-1 \u548c IL-1 \u03b2 \u86cb\u767d\u7684\u6c34\u5e73<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib233\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib233\"><span class=\"anchor-text\">[233]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u6843\u7ea2\u56db\u7269\u6c64<\/th>\n<td>\u4e2d\u8111\u7f3a\u8840\/\u518d\u704c\u6ce8<\/td>\n<td>\u8910\u5bb6\u9f20<\/td>\n<td>\u6291\u5236 HMGB1\/TLR4\/NF-kB \u548c MAPK \u4fe1\u53f7\u901a\u8def<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib234\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib234\"><span class=\"anchor-text\">[234]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u8111\u5fc3\u6e05\u80f6\u56ca<\/th>\n<td>\u4e2d\u8111\u7f3a\u8840\/\u518d\u704c\u6ce8<\/td>\n<td>\u722a\u6c99\u9f20<\/td>\n<td>\u4e0b\u8c03 ASC\u3001NLRP3 \u548c Caspase-1 \u86cb\u767d\uff1b\u964d\u4f4e IL-18 \u548c IL-1\u03b2 \u542b\u91cf\u3002<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib239\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib239\"><span class=\"anchor-text\">[239]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u8865\u9633\u8fd8\u4e94\u6c64<\/th>\n<td>\u4e2d\u8111\u7f3a\u8840\/\u518d\u704c\u6ce8<\/td>\n<td>\u8910\u5bb6\u9f20<\/td>\n<td>\u6291\u5236 NLRP3 \u4ecb\u5bfc\u7684\u7ecf\u5178\u7ec6\u80de\u7126\u4ea1\u9014\u5f84\u7684 NLRP3\u3001ASC\u3001pro-caspase-1\u3001caspase-1 \u548c IL-1\u03b2 \u86cb\u767d\u7684\u8868\u8fbe<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib244\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib244\"><span class=\"anchor-text\">[244]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u9f99\u829d\u6c64<\/th>\n<td>\u4e2d\u8111\u7f3a\u8840\/\u518d\u704c\u6ce8<\/td>\n<td>\u8910\u5bb6\u9f20<\/td>\n<td>\u4e0b\u8c03 Caspase-1 \u548c IL-18 \u86cb\u767d\u7684\u8868\u8fbe<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib245\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib245\"><span class=\"anchor-text\">[245]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u76ca\u6c14\u6d3b\u8840\u65b9<\/th>\n<td>MCAO<\/td>\n<td>\u8910\u5bb6\u9f20<\/td>\n<td>\u964d\u4f4e IL-1\u03b2\u3001TNF-\u03b1 \u548c IL-18 \u7684\u6c34\u5e73\u4ee5\u53ca P2RX7\u3001Caspase-1\u3001Caspase-11 \u548c GSDMD \u7684\u76f8\u5bf9\u8868\u8fbe<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib247\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib247\"><span class=\"anchor-text\">[247]<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">\u795e\u8111\u6276\u5143\u6c64<\/th>\n<td>\u5965\u683c\u5fb7<\/td>\n<td>\u6765\u81ea\u8910\u5bb6\u9f20\u7684 PC12 \u7ec6\u80de<\/td>\n<td>\u6291\u5236 NLRP3\/Caspase-1<\/td>\n<td><a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bib250\" data-sd-ui-side-panel-opener=\"true\" data-xocs-content-type=\"reference\" data-xocs-content-id=\"bib250\"><span class=\"anchor-text\">[250]<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/section>\n<\/section>\n<section id=\"sec0195\">\n<h2 id=\"sect0215\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">6. \u524d\u666f<\/h2>\n<p id=\"p0255\">\u672c\u8bfe\u9898\u7ec4\u957f\u671f\u7814\u7a76IS\u540e\u8840\u7ba1\u795e\u7ecf\u5355\u5143\u5185\u5404\u7c7b\u7ec6\u80de\u7fa4\uff08\u5982\u795e\u7ecf\u5143\u3001\u5c0f\u80f6\u8d28\u7ec6\u80de\u3001\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u7b49\uff09\u7684\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u6a21\u5f0f\uff0c\u7ed3\u5408\u5176\u4ed6\u7814\u7a76\u62a5\u9053\u53d1\u73b0IS\u540e\u53d1\u751f\u4e86\u51cb\u4ea1\u3001\u94c1\u6b7b\u4ea1\u3001\u81ea\u566c\u7b49\u591a\u79cd\u7ec6\u80de\u6b7b\u4ea1\u65b9\u5f0f\uff0c\u4e14\u51cb\u4ea1\u4e0e\u7ec6\u80de\u7126\u4ea1\u7684\u5f62\u6001\u5177\u6709\u4e00\u5b9a\u7684\u76f8\u4f3c\u6027\u3002\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u795e\u7ecf\u708e\u75c7\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/neuroinflammation\">\u795e\u7ecf\u708e\u75c7<\/a>\u00a0IS\u540e\u662f\u5bfc\u81f4\u8111\u635f\u4f24\u6700\u91cd\u8981\u7684\u75c5\u7406\u8fc7\u7a0b\uff0c\u5176\u4e2d\u7ec6\u80de\u7126\u4ea1\u662f\u795e\u7ecf\u708e\u75c7\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\u3002\u8fd9\u8868\u660e\u7126\u4ea1\u5728\u8111\u7f3a\u8840\u540e\u795e\u7ecf\u708e\u75c7\u76f8\u5173\u7684\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u4e2d\u5f02\u5e38\u91cd\u8981\u3002\u7126\u4ea1\u89e6\u53d1\u7684\u76f8\u5173\u4fe1\u53f7\u901a\u8def\u4e5f\u4e0e\u5176\u4ed6\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u901a\u8def\u4ea4\u53c9\uff0c\u8fd9\u8868\u660e\u9488\u5bf9\u7126\u4ea1\u7684\u836f\u7269\u5f00\u53d1\u662f\u6cbb\u7597IS\u7684\u91cd\u8981\u9014\u5f84\u3002<\/p>\n<p id=\"p0260\">\u5c31\u76ee\u524d\u7684\u7814\u7a76\u800c\u8a00\uff0c\u4ecd\u5b58\u5728\u9700\u8981\u6539\u8fdb\u7684\u5730\u65b9\uff1a\uff081\uff09\u7531\u4e8e\u76ee\u524d\u7814\u7a76\u7684\u52a8\u7269\u6a21\u578b\u5b58\u5728\u6807\u51c6\u5316\u548c\u7edf\u4e00\u6027\u7684\u95ee\u9898\uff0c\u5173\u4e8e\u4e0d\u540c\u7ec6\u80de\u7126\u4ea1\u7684\u7ed3\u8bba\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u795e\u7ecf\u7cfb\u7edf\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/nervous-system\">\u795e\u7ecf\u7cfb\u7edf<\/a>\u00a0\u4e0d\u4e00\u81f4\u3002\u56e0\u6b64\uff0c\u672a\u6765\u5bf9\u7ec6\u80de\u7126\u4ea1\u7684\u7814\u7a76\u9700\u8981\u5728\u7f3a\u8840\u6027\u8111\u5352\u4e2d\u52a8\u7269\u6a21\u578b\u4e2d\u5efa\u7acb\u66f4\u52a0\u6807\u51c6\u5316\u3001\u7edf\u4e00\u7684\u7a33\u5b9a\u6a21\u578b\uff0c\u8fd9\u4e5f\u53ef\u4ee5\u786e\u5b9a\u6297\u7ec6\u80de\u7126\u4ea1\u836f\u7269\u7684\u771f\u5b9e\u6548\u679c\u3002 (2)\u672a\u6765\u7684\u7814\u7a76\u53ef\u4ee5\u5728\u591a\u79cd\u556e\u9f7f\u52a8\u7269\u548c\u5927\u578b\u54fa\u4e73\u52a8\u7269\u4e2d\u98ce\u6a21\u578b\u4e2d\u9a8c\u8bc1\u5929\u7136\u5316\u5408\u7269\u7684\u957f\u671f\u8111\u4fdd\u62a4\u4f5c\u7528\u4ee5\u53ca\u8c03\u8282\u7ec6\u80de\u7126\u4ea1\u7684\u673a\u5236\u3002\u4eca\u540e\u5e94\u66f4\u52a0\u91cd\u89c6\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pharmacokinetics\">\u836f\u4ee3\u52a8\u529b\u5b66<\/a>,\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u836f\u6548\u5b66\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pharmacodynamics\">\u836f\u6548\u5b66<\/a>\u4ee5\u53ca\u76ee\u524d\u8c03\u8282\u7ec6\u80de\u7126\u4ea1\u7684\u5929\u7136\u5316\u5408\u7269\u7684\u6bd2\u7406\u5b66\u7279\u6027\u3002\uff083\uff09\u6b64\u5916\uff0c\u672a\u6765\u8fd8\u9700\u63a2\u7d22\u5929\u7136\u5316\u5408\u7269\u7ec4\u5408\u5728\u8c03\u8282\u8111\u7f3a\u8840\u6027\u5352\u4e2d\u7ec6\u80de\u7126\u4ea1\u4e2d\u7684\u534f\u540c\u4f5c\u7528\u4ee5\u53ca\u6291\u5236\u795e\u7ecf\u708e\u75c7\u7684\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u3002\uff084\uff09\u5982\u679c\u6240\u6709\u7ed3\u679c\u90fd\u662f\u6709\u5229\u7684\uff0c\u4e0b\u4e00\u6b65\u5c06\u8fdb\u884c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u4e34\u5e8a\u8bd5\u9a8c\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/clinical-trial\">\u4e34\u5e8a\u8bd5\u9a8c<\/a>\u00a0\u6f5c\u529b\u7684\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u690d\u7269\u5316\u5b66\u7269\u8d28\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/phytochemical\">\u690d\u7269\u5316\u5b66\u7269\u8d28<\/a>\u00a0\u7814\u7a76\u5176\u5bf9\u8111\u7f3a\u8840\/\u4e2d\u98ce\u7684\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\uff08\u4f8b\u5982\uff0c\u8be5\u56e2\u961f\u76ee\u524d\u6b63\u8fdb\u884c\u8111\u6cf0\u65b9\u6cbb\u7597\u8111\u5c0f\u8840\u7ba1\u75c5\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff1aChiCTR1900024524\uff09\u3002<\/p>\n<\/section>\n<section id=\"sec0200\">\n<h2 id=\"sect0220\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">\u4e03\u3001\u603b\u7ed3<\/h2>\n<p id=\"p0265\">\u7126\u4ea1\u4f5c\u4e3a\u4e00\u79cd\u4fc3\u708e\u6027\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\uff0c\u4e3b\u8981\u901a\u8fc7Caspase-1\u4ecb\u5bfc\u7684\u7ecf\u5178\u7126\u4ea1\u9014\u5f84\u8bf1\u5bfc\u7ec6\u80de\u6b7b\u4ea1\u548c\u795e\u7ecf\u708e\u75c7\uff0c\u5728\u7f3a\u8840\u6027\u8111\u5352\u4e2d\u7684\u75c5\u7406\u8fc7\u7a0b\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002\u975e\u5178\u578b\u7126\u4ea1\u9014\u5f84\u4e0e IS \u4e4b\u95f4\u7684\u5173\u7cfb\u4ecd\u6709\u5f85\u9610\u660e\u3002\u7126\u4ea1\u7684\u5176\u4ed6\u673a\u5236\u9700\u8981\u672a\u6765\u8fdb\u4e00\u6b65\u7814\u7a76\u3002\u76ee\u524d\uff0c\u7814\u7a76\u8bc1\u5b9e\uff0c\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u836f\u7269\u9776\u5411\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/drug-delivery-system\">\u836f\u7269\u9776\u5411<\/a>\u00a0\u7ec6\u80de\u7126\u4ea1\u9014\u5f84\u5173\u952e\u86cb\u767d\u80fd\u591f\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u51cf\u8f7b\u7f3a\u8840\u6027\u8111\u635f\u4f24\uff0c\u4f46\u5176\u7814\u7a76\u4e3b\u8981\u5c40\u9650\u4e8e\u7ec6\u80de\u548c\u52a8\u7269\u5b9e\u9a8c\uff0c\u7f3a\u4e4f\u5bf9\u00a0<a class=\"topic-link\" title=\"\u4ece ScienceDirect \u7684 AI \u751f\u6210\u7684\u4e3b\u9898\u9875\u9762\u4e86\u89e3\u6709\u5173\u4e34\u5e8a\u7814\u7a76\u7684\u66f4\u591a\u4fe1\u606f\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/clinical-research\">\u4e34\u5e8a\u7814\u7a76<\/a>\u00a0\u56e0\u6b64\uff0c\u8fdb\u4e00\u6b65\u5f00\u5c55\u4e34\u5e8a\u7814\u7a76\u63a2\u8ba8\u7f3a\u8840\u6027\u4e2d\u98ce\u4e2d\u7ec6\u80de\u7126\u4ea1\u7684\u8c03\u63a7\u673a\u5236\uff0c\u6709\u671b\u4e3a\u7f3a\u8840\u6027\u4e2d\u98ce\u7684\u9632\u6cbb\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u7b56\u7565\u548c\u7406\u8bba\u4f9d\u636e\u3002\u5173\u4e8e\u5929\u7136\u5316\u5408\u7269\u5bf9\u7ec6\u80de\u7126\u4ea1\u7684\u8c03\u63a7\uff0c\u901a\u8fc7\u6211\u4eec\u7684\u5f52\u7eb3\uff0c\u53ef\u4ee5\u53d1\u73b0\u5929\u7136\u690d\u7269\u5316\u5408\u7269\u4e0d\u4ec5\u53ef\u4ee5\u901a\u8fc7\u8c03\u8282\u5355\u4e00\u6210\u5206\u7684\u7ec6\u80de\u7126\u4ea1\u6765\u8c03\u63a7\u8111\u7f3a\u8840\uff0c\u8fd8\u53ef\u4ee5\u770b\u5230\u591a\u6210\u5206\u5929\u7136\u690d\u7269\u5316\u5408\u7269\u5728\u8c03\u63a7\u7ec6\u80de\u7126\u4ea1\u5f15\u53d1\u7684\u708e\u75c7\u7ea7\u8054\u65b9\u9762\u8868\u73b0\u51fa\u6f5c\u5728\u7684\u534f\u540c\u4f5c\u7528\u3002\u8fd9\u542f\u53d1\u6211\u4eec\u4eca\u540e\u7814\u7a76\u5404\u79cd\u5929\u7136\u5316\u5408\u7269\u5bf9\u4e0d\u540c\u4fe1\u53f7\u901a\u8def\u5f15\u8d77\u7684\u7ec6\u80de\u7126\u4ea1\u4ecb\u5bfc\u7684\u795e\u7ecf\u708e\u75c7\u7684\u8c03\u63a7\u4f5c\u7528\u3002<\/p>\n<\/section>\n<section id=\"sec0205\">\n<h2 id=\"sect0225\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">CRediT \u4f5c\u8005\u8d21\u732e\u58f0\u660e<\/h2>\n<p id=\"p0270\"><strong>\u6768\u51ef\u7433\uff1a<\/strong>\u00a0\u6982\u5ff5\u5316\u3001\u65b9\u6cd5\u8bba\u3001\u5f62\u5f0f\u5206\u6790\u3001\u8c03\u67e5\u3001\u5199\u4f5c\u2014\u2014\u539f\u59cb\u8349\u7a3f\uff1b\u00a0<strong>\u66fe\u6d41\u5a77\uff1a<\/strong>\u00a0\u6982\u5ff5\u5316\u3001\u65b9\u6cd5\u8bba\u3001\u8f6f\u4ef6\u3001\u5f62\u5f0f\u5206\u6790\u3001\u8c03\u67e5\u3001\u5199\u4f5c\u2014\u2014\u539f\u59cb\u7a3f\uff1b\u00a0<strong>\u66fe\u52b2\u677e\uff1a<\/strong>\u00a0\u65b9\u6cd5\u8bba\u3001\u5f62\u5f0f\u5206\u6790\u3001\u8c03\u67e5\uff1b\u00a0<strong>\u9c8d\u5a77\u5a77\uff1a<\/strong>\u00a0\u65b9\u6cd5\u8bba\u3001\u5f62\u5f0f\u5206\u6790\u3001\u8c03\u67e5\u3001\u5199\u4f5c\u2014\u2014\u539f\u7a3f\uff1b\u00a0<strong>\u8096\u8fdc\uff1a<\/strong>\u00a0\u65b9\u6cd5\u8bba\u3001\u5f62\u5f0f\u5206\u6790\u3001\u8c03\u67e5\uff1b\u00a0<strong>\u738b\u73ca\u73ca\uff1a<\/strong>\u00a0\u65b9\u6cd5\u8bba\u3001\u5f62\u5f0f\u5206\u6790\u3001\u8c03\u67e5\uff1b\u00a0<strong>\u738b\u7fd4\uff1a<\/strong>\u00a0\u65b9\u6cd5\u8bba\u3001\u5f62\u5f0f\u5206\u6790\u3001\u8c03\u67e5\uff1b\u00a0<strong>\u5f90\u6d69\uff1a<\/strong>\u00a0\u65b9\u6cd5\u8bba\u3001\u5f62\u5f0f\u5206\u6790\u3001\u8c03\u67e5\uff1b\u00a0<strong>\u845b\u91d1\u6587\uff1a<\/strong>\u00a0\u6982\u5ff5\u5316\u3001\u65b9\u6cd5\u8bba\u3001\u5f62\u5f0f\u5206\u6790\u3001\u8c03\u67e5\u3001\u5199\u4f5c\u2014\u2014\u8bc4\u8bba\u548c\u7f16\u8f91\u3002<\/p>\n<\/section>\n<\/div>\n<section id=\"coi0005\">\n<h2 id=\"sect0230\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">\u5229\u76ca\u51b2\u7a81\u58f0\u660e<\/h2>\n<p id=\"p0275\">\u4f5c\u8005\u58f0\u660e\uff0c\u4ed6\u4eec\u6ca1\u6709\u5df2\u77e5\u7684\u53ef\u80fd\u5f71\u54cd\u672c\u6587\u62a5\u544a\u5de5\u4f5c\u7684\u76f8\u4e92\u7ade\u4e89\u7684\u7ecf\u6d4e\u5229\u76ca\u6216\u4e2a\u4eba\u5173\u7cfb\u3002<\/p>\n<\/section>\n<section id=\"ack0005\">\n<h2 id=\"sect0235\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">\u81f4\u8c22<\/h2>\n<p id=\"p0280\">\u8fd9\u9879\u5de5\u4f5c\u5f97\u5230\u4e86\u00a0<span id=\"gs1\">\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u59d4<\/span>\u00a0(<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs1\"><span class=\"anchor-text\">81774174<\/span><\/a>\uff09\uff0c \u8fd9\u00a0<span id=\"gs2\">\u56fd\u5bb6\u91cd\u70b9\u7814\u53d1\u8ba1\u5212\u9879\u76ee<\/span>\u00a0\uff08\u4e0d\u3002\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs2\"><span class=\"anchor-text\">2018YFC1704904<\/span><\/a>),\u00a0<span id=\"gs3\">\u6e56\u5357\u7701\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1<\/span>\uff0c \u4e2d\u56fd \uff08<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs3\"><span class=\"anchor-text\">2020JJ5424<\/span><\/a>\u00a0\u548c\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs3\"><span class=\"anchor-text\">2020JJ5442<\/span><\/a>),\u00a0<span id=\"gs4\">\u6e56\u5357\u4e2d\u533b\u836f\u5927\u5b66\u201c\u53cc\u4e00\u6d41\u201d\u4e2d\u897f\u533b\u7ed3\u5408\u5b66\u79d1\u5f00\u653e\u57fa\u91d1\u9879\u76ee<\/span>\u00a0(<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs4\"><span class=\"anchor-text\">2020ZXYJH08<\/span><\/a>\u00a0\u548c\u00a0<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs4\"><span class=\"anchor-text\">2020ZXYJH09<\/span><\/a>),\u00a0<span id=\"gs5\">\u6e56\u5357\u7701\u6559\u80b2\u5385\u9752\u5e74\u57fa\u91d1\u9879\u76ee<\/span>\u00a0(<a class=\"anchor u-display-inline anchor-paragraph\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#gs5\"><span class=\"anchor-text\">21B0386<\/span><\/a>).<\/p>\n<\/section>\n<\/div>\n<div class=\"text-content u-font-serif\">\n<section id=\"da0005\">\n<h2 id=\"sect0020\" class=\"u-h4 u-margin-l-top u-margin-xs-bottom\">\u6570\u636e\u548c\u6750\u6599\u7684\u53ef\u7528\u6027<\/h2>\n<p id=\"p0020\">\u7528\u4e8e\u652f\u6301\u672c\u7814\u7a76\u7ed3\u679c\u7684\u6570\u636e\u5305\u542b\u5728\u6587\u7ae0\u4e2d\u3002<\/p>\n<\/section>\n<\/div>\n<div class=\"Tail text-s\"><\/div>\n<section id=\"bibliog0005\" class=\"bibliography u-font-serif text-s\">\n<h2 class=\"section-title u-h4 u-margin-l-top u-margin-xs-bottom\">\u53c2\u8003<\/h2>\n<section id=\"bb0005\" class=\"bibliography-sec\">\n<ol id=\"reference-links-bb0005\" class=\"references\">\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib1\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib1\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[1]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">LE \u57c3\u6587\u65af\u3001JL \u6cf0\u52d2\u3001CJ \u53f2\u5bc6\u65af\u3001HAT \u666e\u91cc\u67e5\u5fb7\u3001AS \u683c\u6797\u65af\u5766\u3001SM \u827e\u4f26<\/div>\n<div id=\"ref-id-sbref1\" class=\"title text-m\">\u5fc3\u8840\u7ba1\u5408\u5e76\u75c7\u3001\u708e\u75c7\u548c\u8111\u5c0f\u8840\u7ba1\u75be\u75c5<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Cardiovasc Res., 117 (13) (2021), \u7b2c 2575-2588 \u9875\uff0c\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1093\/cvr\/cvab284\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1093\/cvr\/cvab284<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">\u67e5\u770bPDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">\u672c\u6587\u53ef\u514d\u8d39\u8bbf\u95ee\u3002<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85121137397&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref1\"><span class=\"anchor-text\">\u5728 Scopus \u4e2d\u67e5\u770b<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Cardiovascular%20comorbidities%2C%20inflammation%2C%20and%20cerebral%20small%20vessel%20disease&amp;publication_year=2021&amp;author=L.E.%20Evans&amp;author=J.L.%20Taylor&amp;author=C.J.%20Smith&amp;author=H.A.T.%20Pritchard&amp;author=A.S.%20Greenstein&amp;author=S.M.%20Allan\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref1\"><span class=\"anchor-text\">\u8c37\u6b4c\u5b66\u672f<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib2\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib2\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[2]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">P. Han, W. Zhang, L. Kang, Y. Ma, L. Fu, L. Jia, H. Yu, X. Chen, L. Hou, L. Wang, X. Yu, M. Kohzuki, Q. Guo<\/div>\n<div id=\"ref-id-sbref2\" class=\"title text-m\">\u8fd0\u52a8\u5bf9\u4e2d\u98ce\u6709\u76ca\u7684\u4e34\u5e8a\u8bc1\u636e<\/div>\n<\/div>\n<div class=\"host u-font-sans\">\u526f\u8bcd\u3002\u8fc7\u671f\u3002\u533b\u5b66\u3002\u751f\u7269\u5b66\uff0c1000\uff082017\uff09\uff0c\u7b2c 131-151 \u9875\uff0c\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1007\/978-981-10-4304-8_9\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1007\/978-981-10-4304-8_9<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">\u67e5\u770b\u6587\u7ae0<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85032976954&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref2\"><span class=\"anchor-text\">\u5728 Scopus \u4e2d\u67e5\u770b<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Clinical%20Evidence%20of%20Exercise%20Benefits%20for%20Stroke&amp;publication_year=2017&amp;author=P.%20Han&amp;author=W.%20Zhang&amp;author=L.%20Kang&amp;author=Y.%20Ma&amp;author=L.%20Fu&amp;author=L.%20Jia&amp;author=H.%20Yu&amp;author=X.%20Chen&amp;author=L.%20Hou&amp;author=L.%20Wang&amp;author=X.%20Yu&amp;author=M.%20Kohzuki&amp;author=Q.%20Guo\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref2\"><span class=\"anchor-text\">\u8c37\u6b4c\u5b66\u672f<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib3\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib3\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[3]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">VL Feigin\u3001M. Brainin\u3001B. Norrving\u3001S. Martins\u3001RL Sacco\u3001W. Hacke\u3001M. Fisher\u3001J. Pandian \u548c P. Lindsay<\/div>\n<div id=\"ref-id-sbref3\" class=\"title text-m\">\u4e16\u754c\u4e2d\u98ce\u7ec4\u7ec7 (WSO)\uff1a2022 \u5e74\u5168\u7403\u4e2d\u98ce\u60c5\u51b5\u8bf4\u660e\u4e66<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Int. J. 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u-font-sans\">\u4f58\u542f\u6b63\u3001\u5f20\u5723\u3001\u96f7\u9e4f<\/div>\n<div id=\"ref-id-sbref83\" class=\"title text-m\">\u7f3a\u8840\u6027\u4e2d\u98ce\u7684\u795e\u7ecf\u7ec6\u80de\u6b7b\u4ea1\u673a\u5236\u53ca\u5176\u6cbb\u7597\u610f\u4e49<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Med Res Rev., 42 (1) (2022), \u7b2c259-305\u9875\uff0c\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1002\/med.21817\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1002\/\u533b\u5b66.21817<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">\u67e5\u770b\u6587\u7ae0<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85105148790&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref83\"><span class=\"anchor-text\">\u5728 Scopus \u4e2d\u67e5\u770b<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Mechanisms%20of%20neuronal%20cell%20death%20in%20ischemic%20stroke%20and%20their%20therapeutic%20implications&amp;publication_year=2022&amp;author=Q.Z.%20Tuo&amp;author=S.T.%20Zhang&amp;author=P.%20Lei\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref83\"><span class=\"anchor-text\">\u8c37\u6b4c\u5b66\u672f<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib84\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib84\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[84]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">\u6881\u4fca\u3001\u738b\u5f3a\u3001\u674e\u5efa\u5f3a\u3001\u90ed\u5b50\u3001\u4f59\u4e1c<\/div>\n<div id=\"ref-id-sbref84\" class=\"title text-m\">\u957f\u94fe\u975e\u7f16\u7801RNA MEG3\u901a\u8fc7\u9776\u5411miR-485\/AIM2\u8f74\u589e\u52a0\u7ec6\u80de\u7126\u4ea1\u4ece\u800c\u4fc3\u8fdb\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24<\/div>\n<\/div>\n<div class=\"host u-font-sans\">\u8fc7\u671f\u3002 Neurol.\uff0c325 (2020)\uff0c\u7b2c 113139 \u6761\uff0c\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.expneurol.2019.113139\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.expneurol.2019.113139<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014488619302869\/pdfft?md5=c32009110f4a234e536f16bbd938c229&amp;pid=1-s2.0-S0014488619302869-main.pdf\" target=\"_blank\" 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u-font-sans\">\u738bLQ\uff0c\u90d1YY\uff0c\u5468HJ\uff0c\u5f20XX\uff0c\u5434P.\uff0c\u6731SM<\/div>\n<div id=\"ref-id-sbref85\" class=\"title text-m\">LncRNA-Fendrr\u901a\u8fc7HERC2\u963b\u6b62NLRC4\u86cb\u767d\u6cdb\u7d20\u5316\u964d\u89e3\u8fdb\u800c\u8c03\u63a7\u5c0f\u80f6\u8d28\u7ec6\u80de\u7126\u4ea1<\/div>\n<\/div>\n<div class=\"host u-font-sans\">\u6469\u5c14\u3002\u533b\u5b66\uff0c27\uff081\uff09\uff082021\uff09\uff0cp\u3002 39\u3001\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1186\/s10020-021-00299-y\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1186\/s10020-021-00299-y<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1008127520302352\/pdfft?md5=fb351049136416482400c5853e989211&amp;pid=1-s2.0-S1008127520302352-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" 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u-font-sans\">Oxid. 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text-m\">\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u75c5\u7406\u751f\u7406\u5b66\uff1a\u5904\u4e8e\u7ec6\u80de\u95f4\u7f51\u7edc\u3001\u708e\u75c7\u548c\u7ec6\u80de\u6b7b\u4ea1\u7684\u5341\u5b57\u8def\u53e3<\/div>\n<\/div>\n<div class=\"comment\">2015<\/div>\n<div class=\"host u-font-sans\">Prog. 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Pekny\u3001MS Sands<\/div>\n<div id=\"ref-id-sbref168\" class=\"title text-m\">\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u6d3b\u5316\u51cf\u5f31\u5728\u5a74\u513f\u795e\u7ecf\u5143\u8721\u6837\u8102\u8910\u8d28\u6c89\u7740\u75c7\u4e2d\u7684\u4f5c\u7528<\/div>\n<\/div>\n<div class=\"host u-font-sans\">\u795e\u7ecf\u79d1\u5b66\u6742\u5fd7\uff0c31 (43) (2011)\uff0c\u7b2c 15575-15585 \u9875\uff0c\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1523\/JNEUROSCI.3579-11.2011\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1523\/JNEUROSCI.3579-11.2011<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">\u67e5\u770b\u6587\u7ae0<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-80054910077&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref168\"><span class=\"anchor-text\">\u5728 Scopus \u4e2d\u67e5\u770b<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=The%20role%20of%20attenuated%20astrocyte%20activation%20in%20infantile%20neuronal%20ceroid%20lipofuscinosis&amp;publication_year=2011&amp;author=S.L.%20Macauley&amp;author=M.%20Pekny&amp;author=M.S.%20Sands\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref168\"><span class=\"anchor-text\">\u8c37\u6b4c\u5b66\u672f<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib170\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib170\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[170]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">BR Barker\u3001DJ Taxman\u3001JP Ting<\/div>\n<div id=\"ref-id-sbref169\" class=\"title text-m\">IL-1\u03b2\/IL-18 \u5904\u7406\u708e\u75c7\u5c0f\u4f53\u4e0e\u5176\u4ed6\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\u4e4b\u95f4\u7684\u4ea4\u53c9\u8c03\u8282<\/div>\n<\/div>\n<div class=\"host u-font-sans\">\u7535\u6d41\u3002\u610f\u89c1\u3002\u514d\u75ab\u5b66\uff0c23 (5) (2011)\uff0c\u7b2c 591-597 \u9875\uff0c\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1016\/j.coi.2011.07.005\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1016\/j.coi.2011.07.005<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor pdf link anchor-default anchor-icon-left\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0952791511000781\/pdfft?md5=0e6bc7b6ed20c8b4763c2aaeedbf4301&amp;pid=1-s2.0-S0952791511000781-main.pdf\" target=\"_blank\" rel=\"nofollow noopener\" aria-describedby=\"ref-id-sbref169\"><span class=\"anchor-text\">\u67e5\u770bPDF<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0952791511000781\" aria-describedby=\"ref-id-sbref169\"><span class=\"anchor-text\">\u67e5\u770b\u6587\u7ae0<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-80053589126&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref169\"><span class=\"anchor-text\">\u5728 Scopus \u4e2d\u67e5\u770b<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Cross-regulation%20between%20the%20IL-1IL-18%20processing%20inflammasome%20and%20other%20inflammatory%20cytokines&amp;publication_year=2011&amp;author=B.R.%20Barker&amp;author=D.J.%20Taxman&amp;author=J.P.%20Ting\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref169\"><span class=\"anchor-text\">\u8c37\u6b4c\u5b66\u672f<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib171\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib171\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[171]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">JY Kim\u3001J. 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u-font-sans\">C.\u5b5f\uff0cJ.\u5f20\uff0cL.\u5f20\uff0cY.\u738b\uff0cZ.\u674e\uff0cJ.\u8d75<\/div>\n<div id=\"ref-id-sbref173\" class=\"title text-m\">NLRP6 \u5728\u5927\u9f20\u8111\u7f3a\u8840\/\u518d\u704c\u6ce8 (I\/R) \u635f\u4f24\u4e2d\u7684\u4f5c\u7528<\/div>\n<\/div>\n<div class=\"host u-font-sans\">J. Mol. 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href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85054186635&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref178\"><span class=\"anchor-text\">\u5728 Scopus \u4e2d\u67e5\u770b<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Evidence%20that%20NLRC4%20inflammasome%20mediates%20apoptotic%20and%20pyroptotic%20microglial%20death%20following%20ischemic%20stroke&amp;publication_year=2019&amp;author=L.%20Poh&amp;author=S.W.%20Kang&amp;author=S.H.%20Baik&amp;author=G.Y.Q.%20Ng&amp;author=D.T.%20She&amp;author=P.%20Balaganapathy&amp;author=S.T.%20Dheen&amp;author=T.%20Magnus&amp;author=M.%20Gelderblom&amp;author=C.G.%20Sobey&amp;author=E.H.%20Koo&amp;author=D.Y.%20Fann&amp;author=T.V.%20Arumugam\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref178\"><span class=\"anchor-text\">\u8c37\u6b4c\u5b66\u672f<\/span><\/a><\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib180\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib180\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[180]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">\u5f90\u9e4f\uff0c\u5f20\u6653\u71d5\uff0c\u5218\u5029\uff0c\u8c22\u9896\uff0c\u77f3\u6653\u71d5\uff0c\u9648\u5efa\u519b\uff0c\u674e\u9896\uff0c\u90ed\u534e\uff0c\u5b59\u8363\uff0c\u6d2a\u82f1\uff0c\u5218\u6653\u71d5\uff0c\u5f90\u521a\u3002<\/div>\n<div id=\"ref-id-sbref179\" class=\"title text-m\">\u5c0f\u80f6\u8d28\u7ec6\u80de TREM-1 \u53d7\u4f53\u901a\u8fc7\u4e0e SYK 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Ismael\u3001L. Zhao\u3001S. Nasoohi\u3001T. Ishrat<\/div>\n<div id=\"ref-id-sbref189\" class=\"title text-m\">\u6291\u5236 NLRP3 \u708e\u75c7\u5c0f\u4f53\u4f5c\u4e3a\u4e2d\u98ce\u540e\u795e\u7ecf\u4fdd\u62a4\u7684\u6f5c\u5728\u65b9\u6cd5<\/div>\n<\/div>\n<div class=\"host u-font-sans\">\u79d1\u5b66\u3002\u4ee3\u8868\uff0c8 (1) (2018)\uff0c\u7b2c 17 \u9875\u3002 5971,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1038\/s41598-018-24350-x\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1038\/s41598-018-24350-x<\/span><\/a><\/div>\n<div class=\"comment\">PMID\uff1a29654318\uff1bPMCID\uff1aPMC5899150\u3002<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\">\n<p><a class=\"es-link found icon-small\" target=\"_blank\" rel=\"noopener\">\u00a0<span class=\"text\">\u67e5\u770bPDF<\/span>\u00a0<\/a><\/p>\n<div class=\"tooltip-container left\">\n<div class=\"icon\"><\/div>\n<p class=\"message\">\u672c\u6587\u53ef\u514d\u8d39\u8bbf\u95ee\u3002<\/p>\n<\/div>\n<\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85045520722&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref189\"><span class=\"anchor-text\">\u5728 Scopus \u4e2d\u67e5\u770b<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Inhibition%20of%20the%20NLRP3-inflammasome%20as%20a%20potential%20approach%20for%20neuroprotection%20after%20stroke&amp;publication_year=2018&amp;author=S.%20Ismael&amp;author=L.%20Zhao&amp;author=S.%20Nasoohi&amp;author=T.%20Ishrat\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref189\"><span class=\"anchor-text\">\u8c37\u6b4c\u5b66\u672f<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib191\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib191\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[191]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">\u5218X\u3001\u5415X\u3001\u5218Z\u3001\u5f20\u660e\u3001\u51b7Y<\/div>\n<div id=\"ref-id-sbref190\" class=\"title text-m\">\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u6765\u6e90\u7684\u7ec6\u80de\u5916\u56ca\u6ce1\u4e2d\u7684 MircoRNA-29a \u901a\u8fc7 TP53INP1 \u548c NF-\u03baB\/NLRP3 \u8f74\u6291\u5236\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Cell Mol. Neurobiol., 42 (5) (2022), pp. 1487-1500,\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1007\/s10571-021-01040-3\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1007\/s10571-021-01040-3<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">\u67e5\u770b\u6587\u7ae0<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85101234736&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref190\"><span class=\"anchor-text\">\u5728 Scopus \u4e2d\u67e5\u770b<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=MircoRNA-29a%20in%20Astrocyte-derived%20Extracellular%20Vesicles%20Suppresses%20Brain%20Ischemia%20Reperfusion%20Injury%20via%20TP53INP1%20and%20the%20NF-BNLRP3%20Axis&amp;publication_year=2022&amp;author=X.%20Liu&amp;author=X.%20Lv&amp;author=Z.%20Liu&amp;author=M.%20Zhang&amp;author=Y.%20Leng\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref190\"><span class=\"anchor-text\">\u8c37\u6b4c\u5b66\u672f<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib192\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib192\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[192]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">\u6881 YB\u3001\u5b8b PP\u3001\u6731 YH\u3001\u5f90 JM\u3001\u6731 PZ\u3001\u5218 RR\u3001\u5f20 YS<\/div>\n<div id=\"ref-id-sbref191\" class=\"title text-m\">TREM-1 \u9776\u5411 LP17 \u901a\u8fc7\u6291\u5236\u6c27\u5316\u5e94\u6fc0\u548c\u7ec6\u80de\u7126\u4ea1\u51cf\u8f7b\u8111\u7f3a\u8840\u5f15\u8d77\u7684\u795e\u7ecf\u5143\u635f\u4f24<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Biochem Biophys. 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u-font-sans\">\u66f9\u6653\u71d5\uff0c\u738b\u9896\uff0c\u9ad8\u73b2<\/div>\n<div id=\"ref-id-sbref195\" class=\"title text-m\">CHRFAM7A \u8fc7\u8868\u8fbe\u901a\u8fc7\u6291\u5236 NLRP3\/Caspase-1 \u901a\u8def\u4ecb\u5bfc\u7684\u5c0f\u80f6\u8d28\u7ec6\u80de\u7126\u4ea1\u51cf\u8f7b\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Inflammation, 44 (3) (2021), \u7b2c 1023-1034 \u9875\uff0c\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1007\/s10753-020-01398-4\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1007\/s10753-020-01398-4<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">\u67e5\u770b\u6587\u7ae0<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" 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Stroke Res., 11 (6) (2020), \u7b2c 1185-1202 \u9875\uff0c\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1007\/s12975-020-00806-z\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1007\/s12975-020-00806-z<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">\u67e5\u770b\u6587\u7ae0<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85082940881&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref218\"><span class=\"anchor-text\">\u5728 Scopus \u4e2d\u67e5\u770b<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Cell%20death%20pathways%20in%20ischemic%20stroke%20and%20targeted%20pharmacotherapy&amp;publication_year=2020&amp;author=A.%20Datta&amp;author=D.%20Sarmah&amp;author=L.%20Mounica&amp;author=H.%20Kaur&amp;author=R.%20Kesharwani&amp;author=G.%20Verma&amp;author=P.%20Veeresh&amp;author=V.%20Kotian&amp;author=K.%20Kalia&amp;author=A.%20Borah&amp;author=X.%20Wang&amp;author=K.R.%20Dave&amp;author=D.R.%20Yavagal&amp;author=P.%20Bhattacharya\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref218\"><span class=\"anchor-text\">\u8c37\u6b4c\u5b66\u672f<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib220\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib220\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[220]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">\u6768K.\uff0c\u66feL.\uff0cA.\u845b\uff0cY.\u9648\uff0cS.\u738b\uff0cX.\u6731\uff0cJ.\u845b<\/div>\n<div id=\"ref-id-sbref219\" class=\"title text-m\">\u57fa\u4e8e\u7cfb\u7edf\u836f\u7406\u5b66\u63a2\u7a76\u7ea2\u82aa-\u5ddd\u828e\u590d\u65b9\u5bf9HIF-VEGF\u901a\u8def\u53ca\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u751f\u7269\u7f51\u7edc\u7684\u8c03\u63a7\u673a\u5236<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Front Pharmacol.\uff0c12 (2021)\uff0c\u6587\u7ae0 601846\uff0c\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.3389\/fphar.2021.601846\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.3389\/fphar.2021.601846<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">\u67e5\u770b\u6587\u7ae0<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85109788788&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref219\"><span class=\"anchor-text\">\u5728 Scopus \u4e2d\u67e5\u770b<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Exploring%20the%20regulatory%20mechanism%20of%20HedysarumMultijugumMaxim.-Chuanxiong%20Rhizoma%20compound%20on%20HIF-VEGF%20pathway%20and%20cerebral%20ischemia-reperfusion%20injurys%20biological%20network%20based%20on%20systematic%20pharmacology&amp;publication_year=2021&amp;author=K.%20Yang&amp;author=L.%20Zeng&amp;author=A.%20Ge&amp;author=Y.%20Chen&amp;author=S.%20Wang&amp;author=X.%20Zhu&amp;author=J.%20Ge\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref219\"><span class=\"anchor-text\">\u8c37\u6b4c\u5b66\u672f<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<li><span class=\"label u-font-sans\"><a id=\"ref-id-bib221\" class=\"anchor anchor-default\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889#bbib221\" data-aa-button=\"sd:product:journal:article:location=references:type=anchor:name=citation-name\"><span class=\"anchor-text\">[221]<\/span><\/a><\/span>\n<div class=\"contribution\">\n<div class=\"authors u-font-sans\">\u738b G., \u66fe X., \u6768 K., \u9f9a S., \u845b A., \u5218 W., \u4f55 Q., \u5f20 W., \u845b J.<\/div>\n<div id=\"ref-id-sbref220\" class=\"title text-m\">\u901a\u8fc7\u5b9a\u91cf\u86cb\u767d\u8d28\u7ec4\u5b66\u63ed\u793a\u9ec4\u82aa-\u5ddd\u828e\u590d\u65b9\u5bf9\u8111\u6897\u6b7b\u7684\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528<\/div>\n<\/div>\n<div class=\"host u-font-sans\">Evid. 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u-font-sans\">\u8c22\u4f1f\u3001\u5b5f\u6653\u3001\u7fdf\u52c7\u3001\u5468\u9e4f\u3001\u53f6\u6d9b\u3001\u738b\u5fd7\u3001\u5b59\u56fd\u5f3a\u3001\u5b59\u6653<\/div>\n<div id=\"ref-id-sbref224\" class=\"title text-m\">\u4e09\u4e03\u7682\u82f7\u6297\u6291\u90c1\u6216\u6297\u7126\u8651\u4f5c\u7528\u673a\u5236\u7efc\u8ff0\u53ca\u690d\u7269\u5316\u5b66\u548c\u836f\u7406\u5b66\u7f51\u7edc\u5206\u6790<\/div>\n<\/div>\n<div class=\"host u-font-sans\">\u5206\u5b50\uff0c23\uff084\uff09\uff082018\uff09\uff0cp\u3002 940\u3001\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.3390\/molecules23040940\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.3390\/\u5206\u5b5023040940<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">\u67e5\u770b\u6587\u7ae0<\/span>\u00a0<\/a><\/div>\n<p><a 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u-font-sans\">\u4f55\u65ed\u3001\u5218\u82f1\u98de\u3001\u738b\u709c\u3001\u8d75\u7ea2\u3001\u95eb\u6653\u6b23\u3001\u6613\u4e9a\u4e54\u3001\u845b\u9526\u6587<\/div>\n<div id=\"ref-id-sbref229\" class=\"title text-m\">\u4e09\u4e03\u603b\u7682\u82f7\u5bf9\u5168\u8111\u7f3a\u8840\u5927\u9f20\u6d77\u9a6c\u8111\u6c34\u80bf\u53caGFAP\u8868\u8fbe\u7684\u5f71\u54cd<\/div>\n<\/div>\n<div class=\"host u-font-sans\">\u4e0b\u5df4\u3002\u8349\u672c\u690d\u7269\u3002\u533b\u5b66, 2017, 48(22), 4695-4700<\/div>\n<div class=\"ReferenceLinks u-font-sans\"><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Effects%20of%20Panax%20notoginseng%20saponins%20on%20hippocampal%20cerebral%20edema%20and%20GFAP%20expression%20in%20rats%20with%20global%20cerebral%20ischemia&amp;publication_year=2017&amp;author=He%20Xu&amp;author=Liu%20Yingfei&amp;author=Wang%20Wei&amp;author=Zhao%20Hong&amp;author=Yan%20Xiaoxin&amp;author=Yi%20Yaqiao&amp;author=Ge%20Jinwen\" 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u-font-sans\">\u4e0b\u5df4\u3002\u8349\u672c\u690d\u7269\u3002\u533b\u5b66\uff0c50(22)(2019)\uff0c\u7b2c5521-5526\u9875<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">\u67e5\u770b\u6587\u7ae0<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/doi.org\/10.3390\/su11195521\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref230\"><span class=\"anchor-text\">\u4ea4\u53c9\u5f15\u7528<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85073589086&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref230\"><span class=\"anchor-text\">\u5728 Scopus \u4e2d\u67e5\u770b<\/span><\/a><a class=\"anchor link anchor-default\" 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text-m\">\u57fa\u4e8eDRP1\/NLRP3\u901a\u8def\u7814\u7a76\u6843\u7ea2\u56db\u7269\u6c64\u5bf9\u6025\u6027\u8111\u6897\u6b7b\u540e\u7ec6\u80de\u7126\u4ea1\u7684\u4f5c\u7528\u53ca\u673a\u5236\u7814\u7a76[D]<\/div>\n<\/div>\n<div class=\"host u-font-sans\">\u5317\u4eac\u5927\u5b66\u4f20\u7edf\u3002\u4e0b\u5df4\u3002\u533b\u5b66\u3002 (2021),\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.26973\/d.cnki.gbjzu.2021.000498\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.26973\/d.cnki.gbjzu.2021.000498<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">\u67e5\u770b\u6587\u7ae0<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" 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text-m\">\u6843\u7ea2\u56db\u7269\u6c64\u5bf9\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u5927\u9f20\u7ec6\u80de\u7126\u4ea1\u8c03\u63a7\u4f5c\u7528\u7684\u7814\u7a76[D]<\/div>\n<\/div>\n<div class=\"host u-font-sans\">\u5b89\u5fbd\u5927\u5b66\u4f20\u7edf\u3002\u4e0b\u5df4\u3002\u533b\u5b66\u3002 (2020),\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.26922\/d.cnki.ganzc.2020.000120\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.26922\/d.cnki.ganzc.2020.000120<\/span><\/a><\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">\u67e5\u770b\u6587\u7ae0<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" 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text-m\">\u9759\u8109\u6ce8\u5c04\u7cbe\u6c28\u9178\u53ef\u4e0b\u8c03 NLRP3 \u708e\u75c7\u5c0f\u4f53\u6d3b\u6027\u5e76\u51cf\u8f7b\u591a\u79cd\u5fae\u751f\u7269\u8113\u6bd2\u75c7\u5c0f\u9f20\u7684\u6025\u6027\u80be\u635f\u4f24<\/div>\n<\/div>\n<div class=\"host u-font-sans\">\u5a92\u4f53\u3002\u708e\u75c7\u3002\uff0c2020 (2020)\uff0c\u6587\u7ae0 3201635\uff0c\u00a0<a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1155\/2020\/3201635\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"anchor-text\">10.1155\/2020\/3201635<\/span><\/a><\/div>\n<div class=\"comment\">\u7535\u8bdd\u53f7\u7801\uff1a32454788\uff1b PMCID\uff1aPMC7238342\u3002<\/div>\n<div class=\"ReferenceLinks u-font-sans\">\n<div class=\"link u-margin-m-right u-display-inline\"><a class=\"es-link found-doi icon-small\" target=\"_blank\" rel=\"noopener\"><span class=\"text\">\u67e5\u770b\u6587\u7ae0<\/span>\u00a0<\/a><\/div>\n<p><a class=\"anchor link anchor-default\" href=\"https:\/\/www.scopus.com\/inward\/record.url?eid=2-s2.0-85085510204&amp;partnerID=10&amp;rel=R3.0.0\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref256\"><span class=\"anchor-text\">\u5728 Scopus \u4e2d\u67e5\u770b<\/span><\/a><a class=\"anchor link anchor-default\" href=\"https:\/\/scholar.google.com\/scholar_lookup?title=Intravenous%20Arginine%20Administration%20Downregulates%20NLRP3%20inflammasome%20activity%20and%20attenuates%20acute%20kidney%20injury%20in%20mice%20with%20polymicrobial%20sepsis&amp;publication_year=2020&amp;author=S.A.%20Tanuseputero&amp;author=M.T.%20Lin&amp;author=S.L.%20Yeh&amp;author=C.L.%20Yeh\" target=\"_blank\" rel=\"noopener noreferrer\" aria-describedby=\"ref-id-sbref256\"><span class=\"anchor-text\">\u8c37\u6b4c\u5b66\u672f<\/span><\/a><\/p>\n<\/div>\n<\/li>\n<\/ol>\n<\/section>\n<\/section>\n<div id=\"section-cited-by\">\n<section class=\"ListArticles preview\" aria-label=\"\u88ab\u5f15\u7528\">\n<div 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class=\"anchor-text\">\u7f3a\u8840\u6027\u4e2d\u98ce\u4e2d\u7ec6\u80de\u7126\u4ea1\u76f8\u5173\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\u7684\u57fa\u56e0\u8868\u8fbe\u8c31\u673a\u5668\u5b66\u4e60\u5206\u6790\u63ed\u793a\u4e86\u836f\u7269\u518d\u5229\u7528\u7684\u6f5c\u5728\u9776\u70b9<\/span><\/a><\/p>\n<div class=\"text-s\">2023\uff0c\u7814\u7a76\u5e7f\u573a<\/div>\n<\/div>\n<div class=\"buttons text-s\"><\/div>\n<\/li>\n<li class=\"ListArticleItem u-margin-l-bottom\">\n<div class=\"sub-heading u-margin-xs-bottom\">\n<p id=\"citing-articles-article-3-title\" class=\"u-font-serif\"><a class=\"anchor anchor-default\" href=\"https:\/\/doi.org\/10.1002\/ptr.7994\" target=\"_blank\" rel=\"noopener\"><span class=\"anchor-text\">\u9488\u5bf9 PI3K\/Akt \u4fe1\u53f7\u4f20\u5bfc\u7684\u690d\u7269\u7597\u6cd5\u6cbb\u7597\u7f3a\u8840\u6027\u4e2d\u98ce\u7684\u8fdb\u5c55<\/span><\/a><\/p>\n<div class=\"text-s\">2023\uff0c\u690d\u7269\u7597\u6cd5\u7814\u7a76<\/div>\n<\/div>\n<div class=\"buttons text-s\"><\/div>\n<\/li>\n<\/ul>\n<\/div>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332222013889\">\u6765\u6e90<\/a><\/p>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>This suggests that breviscapine may significantly improve the cognitive function of CCI rats and reduce the pathological damage of ischemic neurons, and its mechanism may be related to the inhibition of NLRP3 inflammasome activation and pyroptosis pathway in brain tissue 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