{"id":5177,"date":"2024-01-16T12:37:46","date_gmt":"2024-01-16T12:37:46","guid":{"rendered":"https:\/\/farlong.com\/?p=5177"},"modified":"2024-01-27T10:26:20","modified_gmt":"2024-01-27T10:26:20","slug":"breviscapine-remodels-myocardial-glucose-and-lipid-metabolism-by-regulating-serotonin-to-alleviate-doxorubicin-induced-cardiotoxicity","status":"publish","type":"post","link":"https:\/\/directcm.com\/zh\/breviscapine-remodels-myocardial-glucose-and-lipid-metabolism-by-regulating-serotonin-to-alleviate-doxorubicin-induced-cardiotoxicity\/","title":{"rendered":"\u706f\u76cf\u82b1\u7d20\u901a\u8fc7\u8c03\u8282\u8840\u6e05\u7d20\u91cd\u5851\u5fc3\u808c\u8461\u8404\u7cd6\u548c\u8102\u8d28\u4ee3\u8c22\u4ee5\u51cf\u8f7b\u963f\u9709\u7d20\u5f15\u8d77\u7684\u5fc3\u810f\u6bd2\u6027"},"content":{"rendered":"<p>\u674e\u68a6\u5a07, 1 , 2 , \u2020 \u5b59\u6587\u793e, 1 , \u2020 \u8881\u9633, 1 , \u2020 \u5f20\u7389\u5764, 1 , 2 \u9646\u5947, 1 , 2 \u9ad8\u5143\u73cd, 1 , 2 \u53f6\u5a77, 1 , 2 \u4e0e\u90a2\u4e1c\u660e\u901a\u8baf\u4f5c\u8005 1 , 3 ,*<\/p>\n<div id=\"abstract-a.k.b.p\" class=\"tsec sec\" lang=\"en\">\n<h2 id=\"abstract-a.k.b.ptitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u62bd\u8c61\u7684<\/h2>\n<div>\n<p class=\"p p-first\"><strong>\u76ee\u6807\uff1a<\/strong>\u00a0\u5e7f\u8c31\u6297\u764c\u836f\u7269\u963f\u9709\u7d20\uff08Dox\uff09\u5177\u6709\u8f83\u9ad8\u7684\u5fc3\u810f\u6bd2\u6027\u53d1\u751f\u7387\uff0c\u4e25\u91cd\u5f71\u54cd\u8be5\u836f\u7269\u7684\u4e34\u5e8a\u5e94\u7528\u548c\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u8bc4\u4f30\u4e86 Dox 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title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"s1title\" class=\"head no_bottom_margin ui-helper-clearfix\">\u4ecb\u7ecd<\/h2>\n<p class=\"p p-first\">\u84bd\u73af\u7c7b\u6297\u751f\u7d20\u963f\u9709\u7d20 (Dox) \u662f\u4e00\u79cd\u9ad8\u6548\u6297\u764c\u836f\u7269\uff0c\u7528\u4e8e\u6cbb\u7597\u5b9e\u4f53\u7624\u3001\u767d\u8840\u75c5\u3001\u6dcb\u5df4\u7624\u548c\u4e73\u817a\u764c\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B43\" aria-expanded=\"false\" aria-haspopup=\"true\">\u7af9\u6751\u548c\u85e4\u539f\uff0c2007<\/a>\uff09\u3002\u4f7f\u7528 Dox \u53ef\u5bfc\u81f4\u8fdb\u884c\u6027\u3001\u6162\u6027\u3001\u5371\u53ca\u751f\u547d\u7684\u5fc3\u808c\u75c5\uff0c\u79f0\u4e3a Dox \u8bf1\u53d1\u7684\u5fc3\u808c\u75c5 (DIC)\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B20\" aria-expanded=\"false\" aria-haspopup=\"true\">\u674e\u7ef4\u65af\u7b49\u4eba\uff0c2017<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B37\" aria-expanded=\"false\" aria-haspopup=\"true\">Sawicki \u7b49\u4eba\uff0c2021<\/a>\uff09\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5728\u764c\u75c7\u60a3\u8005\u4e2d\uff0c\u56e0\u836f\u7269\u76f8\u5173\u5fc3\u810f\u6bd2\u6027\u800c\u6b7b\u4ea1\u7684\u98ce\u9669\u8d85\u8fc7\u56e0\u80bf\u7624\u672c\u8eab\u6216\u590d\u53d1\u800c\u6b7b\u4ea1\u7684\u98ce\u9669\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B24\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5218\u7b49\u4eba\uff0c2017<\/a>\uff09\u3002\u670d\u7528\u4f4e\u5242\u91cf\u7684 Dox 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\u7684\u53d1\u5c55\u3002\u5fc3\u810f\u7684\u4ee3\u8c22\u5fae\u73af\u5883\u3002\u8fd1\u5e74\u6765\uff0cDIC\u6f5c\u5728\u5206\u5b50\u673a\u5236\u7684\u7814\u7a76\u4e3b\u8981\u96c6\u4e2d\u5728\u7ea2\u6c27\u7a33\u6001\u5931\u8861\u3001\u62d3\u6251\u5f02\u6784\u9176II\u03b2\uff08Top2b\uff09\u8f6c\u5f55\u6291\u5236\u3001\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u548cCa<sup>2+<\/sup>-\u5904\u7406\u5f02\u5e38\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B45\" aria-expanded=\"false\" aria-haspopup=\"true\">Vejpongsa \u548c Yeh\uff0c2014<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B15\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5361\u5229\u4e9a\u7eb3\u62c9\u66fc\uff0c2020<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B13\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8d6b\u5c14\u65af\u7279\u7b49\u4eba\uff0c2021<\/a>\uff09\u3002\u5fc3\u810f\u6d88\u8017\u4f53\u5185\u6700\u5927\u7684\u80fd\u91cf\uff0cDox \u91cd\u5851\u5fc3\u810f\u4ee3\u8c22\u3002\u7136\u800c\uff0c\u9a71\u52a8 DIC \u53d1\u5c55\u7684\u6539\u53d8\u5c1a\u4e0d\u5b8c\u5168\u6e05\u695a\u3002\u901a\u8fc7\u8c03\u8282\u5fc3\u810f\u4ee3\u8c22\u7f51\u7edc\u6765\u9884\u9632 DIC \u7684\u6cbb\u7597\u7b56\u7565\u5c1a\u672a\u5efa\u7acb\u3002<\/p>\n<p>\u5fc3\u810f\u80fd\u91cf\u4ee3\u8c22\u6d89\u53ca\u590d\u6742\u7684\u76f8\u4e92\u4f5c\u7528\u9014\u5f84\uff0c\u5bfc\u81f4\u5229\u7528\u6bcf\u4e00\u7c7b\u80fd\u91cf\u5e95\u7269\u8fdb\u884c ATP \u751f\u4ea7\u6216\u751f\u7269\u5408\u6210\u3002\u8be5\u7f51\u7edc\u6700\u663e\u7740\u7684\u7279\u5f81\u662f\u54cd\u5e94\u5404\u79cd\u523a\u6fc0\u800c\u8868\u73b0\u51fa\u7684\u4ee3\u8c22\u7075\u6d3b\u6027\uff0c\u5305\u62ec\u53d1\u80b2\u53d8\u5316\u3001\u8425\u517b\u72b6\u51b5\u3001\u6162\u6027\u75c5\u7406\u751f\u7406\u72b6\u51b5\u548c\u836f\u7269\u5e72\u9884\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B29\" aria-expanded=\"false\" aria-haspopup=\"true\">Murashige \u7b49\u4eba\uff0c2020<\/a>\uff09\u3002\u7ebf\u7c92\u4f53\u662f\u4e00\u79cd\u591a\u7528\u9014\u7ec6\u80de\u5668\uff0c\u5360\u5fc3\u808c\u7ec6\u80de\u4f53\u79ef\u7684\u4e09\u5206\u4e4b\u4e00\uff0c\u4e0d\u4ec5\u4ea7\u751f\u5fc3\u810f\u6240\u5229\u7528\u7684\u8d85\u8fc7 95% \u7684 ATP\uff0c\u8fd8\u8c03\u8282\u7ec6\u80de\u5185\u9499\u7a33\u6001\u3001\u4fe1\u53f7\u8f6c\u5bfc\u548c\u7ec6\u80de\u6b7b\u4ea1\uff0c\u662f\u534f\u8c03\u80fd\u91cf\u7684\u6838\u5fc3\u8f6c\u5bfc\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B18\" aria-expanded=\"false\" aria-haspopup=\"true\">\u79d1\u7ef4\u5947\u7b49\u4eba\uff0c2013<\/a>\uff09\u3002\u5c3d\u7ba1\u5fc3\u810f\u80fd\u591f\u5229\u7528\u5404\u79cd\u80fd\u91cf\u5e95\u7269\uff08\u5305\u62ec\u78b3\u6c34\u5316\u5408\u7269\u3001\u8102\u8d28\u3001\u6c28\u57fa\u9178\u548c\u916e\u4f53\uff09\u6765\u4ea7\u751f ATP\uff0c\u4f46\u6240\u4f7f\u7528\u7684\u5e95\u7269\u4f1a\u5f71\u54cd\u5fc3\u810f\u6548\u7387\u3002\u5728\u80a5\u80d6\u548c\u7cd6\u5c3f\u75c5\u7684\u60c5\u51b5\u4e0b\uff0c\u8102\u80aa\u9178\u6d53\u5ea6\u548c\u6c27\u5316\u5347\u9ad8\u4e0e\u8461\u8404\u7cd6\u6c27\u5316\u51cf\u5c11\u6709\u5173\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B34\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5170\u5fb7\u5c14\u7b49\u4eba\uff0c1963<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B23\" aria-expanded=\"false\" aria-haspopup=\"true\">\u674e\u548c\u5f20\uff0c2016<\/a>\uff09\u3002\u5fc3\u810f\u529f\u80fd\u969c\u788d\u4e0e\u5fc3\u808c\u8017\u6c27\u91cf\u589e\u52a0\u3001\u5fc3\u810f\u6548\u7387\u964d\u4f4e\u548c\u6c27\u5316\u5e94\u6fc0\u589e\u52a0\u6709\u5173\uff0c\u8868\u660e\u8102\u80aa\u9178\u6c27\u5316\uff08FAO\uff09\u589e\u52a0\u5bf9\u5fc3\u810f\u529f\u80fd\u6709\u5bb3\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B25\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6d1b\u5e15\u8212\u514b\u7b49\u4eba\uff0c2010<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B26\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6d1b\u5e15\u8212\u514b\u7b49\u4eba\uff0c2021<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B54\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5c71\u672c\u548c\u4f50\u91ce\uff0c2022<\/a>\uff09\u3002\u9ad8FAO\u4ea7\u751f\u4e0d\u5229\u5f71\u54cd\u7684\u673a\u5236\u4e4b\u4e00\u662f\u6c27\u6548\u7387\u964d\u4f4e\u548c\u8102\u80aa\u9178\u884d\u751f\u7269\u6c34\u5e73\u589e\u52a0\uff0c\u8fd9\u53ef\u80fd\u901a\u8fc7\u7ebf\u7c92\u4f53\u89e3\u5076\u8054\u8fdb\u4e00\u6b65\u964d\u4f4e\u6548\u7387\u3002\u4e8b\u5b9e\u4e0a\uff0c\u5728 DIC \u4e2d\u89c2\u5bdf\u5230\u8102\u8d28\u8fc7\u6c27\u5316 (LP) \u5347\u9ad8\uff0c\u8fd9\u8868\u660e\u9ad8FAO\u53ef\u80fd\u662f\u5fc3\u810f\u635f\u4f24\u7684\u5173\u952e\u9014\u5f84\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u5047\u8bbe Dox \u6cbb\u7597\u671f\u95f4\u5fc3\u810f\u4ee3\u8c22\u91cd\u5851\u589e\u52a0\u4e86\u8102\u80aa\u9178\u7684\u6444\u53d6\u548c\u6c27\u5316\uff0c\u5bfc\u81f4 ATP \u751f\u4ea7\u6548\u7387\u4f4e\u4e0b\uff0c\u4f34\u968f\u7740\u9ad8\u8017\u6c27\u91cf\u548c\u6c27\u5316\u5e94\u6fc0\uff0c\u800c\u5fc3\u810f\u6548\u7387\u7684\u964d\u4f4e\u53cd\u8fc7\u6765\u53c8\u53cd\u9988\u5230\u8102\u80aa\u9178\u5229\u7528\u7387\u7684\u589e\u5f3a\u7ebf\u7c92\u4f53\u635f\u4f24\uff0c\u8fdb\u800c\u52a0\u901f DIC \u7684\u8fdb\u5c55\u3002<\/p>\n<p>\u6709\u8da3\u7684\u662f\uff0c\u6d41\u884c\u75c5\u5b66\u7814\u7a76\u8868\u660e\uff0c\u7ecf\u5e38\u98df\u7528\u5bcc\u542b\u7c7b\u9ec4\u916e\u7684\u98df\u7269\u53ef\u80fd\u4f1a\u964d\u4f4e\u8bb8\u591a\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u98ce\u9669\uff0c\u800c\u4e14\u8bb8\u591a\u5929\u7136\u7c7b\u9ec4\u916e\u5316\u5408\u7269\u5df2\u88ab\u8bc1\u660e\u53ef\u4ee5\u4fdd\u62a4\u5fc3\u810f\u529f\u80fd\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B38\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6c99\u5df4\u62c9\u62c9\u7b49\u4eba\uff0c2017<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B42\" aria-expanded=\"false\" aria-haspopup=\"true\">Syahputra \u7b49\u4eba\uff0c2022<\/a>).\u00a0<em>\u706f\u76cf\u82b1<\/em>\uff0c\u4e5f\u79f0\u4e3a\u00a0<em>\u706f\u76cf\u82b1<\/em>\u00a0\u6216\u7f57\u5e03\u9ebb\uff0c\u662f\u4e00\u79cd\u4f20\u7edf\u8349\u836f\uff0c\u5df2\u6709 600 \u591a\u5e74\u7684\u4f7f\u7528\u5386\u53f2\u3002 Breviscapine \u662f\u4e00\u79cd\u7c7b\u9ec4\u916e\u6210\u5206\u00a0<em>\u706f\u76cf\u82b1<\/em>\u00a0\u5177\u6709\u5e7f\u6cdb\u7684\u836f\u7406\u4f5c\u7528\uff0c\u5982\u6297\u6c27\u5316\u3001\u6297\u708e\u548c\u6297\u80bf\u7624\u4f5c\u7528\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B10\" aria-expanded=\"false\" aria-haspopup=\"true\">\u9ad8\u7b49\uff0c2017<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B48\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6e29\u7b49\u4eba\uff0c2021<\/a>\uff09\u3002\u706f\u76cf\u82b1\u7d20\u6ce8\u5c04\u6db2\u662f\u6211\u56fd\u6cbb\u7597\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u5e94\u7528\u6700\u5e7f\u6cdb\u7684\u7ecf\u5178\u836f\u7269\uff0c\u4e5f\u662f\u6211\u56fd\u533b\u9662\u6025\u6551\u7684\u91cd\u8981\u836f\u7269\u3002\u706f\u76cf\u82b1\u7d20\u5e94\u7528\u4e8e\u4e34\u5e8a\u6cbb\u7597\u9ad8\u8840\u538b\u3001\u8111\u6813\u585e\u3001\u8111\u8840\u7ba1\u75be\u75c5\u5df2\u670920\u591a\u5e74\u7684\u5386\u53f2\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B50\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5434\u7b49\u4eba\uff0c2019<\/a>\uff09\u3002\u4f46\u76ee\u524d\u5c1a\u65e0\u5176\u5bf9\u5316\u7597\u836f\u7269\u5f15\u8d77\u7684\u5fc3\u810f\u635f\u4f24\u7684\u4fdd\u62a4\u4f5c\u7528\u7684\u62a5\u9053\u3002<\/p>\n<p class=\"p p-last\">\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u901a\u8fc7\u5229\u7528H9c2\u5927\u9f20\u5fc3\u808c\u7ec6\u80de\u548cC57BL\/6\u5c0f\u9f20\u5efa\u7acb\u84bd\u73af\u7c7b\u836f\u7269\u8bf1\u5bfc\u7684\u5fc3\u808c\u635f\u4f24\u6a21\u578b\uff0c\u63a2\u8ba8\u706f\u76cf\u82b1\u7d20\u5bf9DIC\u7684\u6f5c\u5728\u5f71\u54cd\u53ca\u5176\u53ef\u80fd\u7684\u5206\u5b50\u673a\u5236\u3002\u6211\u4eec\u8fd8\u7cfb\u7edf\u5730\u9610\u660e\u4e86\u706f\u76cf\u82b1\u7d20\u53ef\u4ee5\u901a\u8fc7\u8461\u8404\u7cd6\u8c03\u8282\u7684\u5206\u652f\u8840\u6e05\u7d20\u9014\u5f84\u63d0\u9ad8\u5fc3\u808c\u8461\u8404\u7cd6\u5229\u7528\u6548\u7387\uff0c\u4ece\u800c\u53d1\u6325\u80f0\u5c9b\u7d20\u6837\u529f\u80fd\uff0c\u5728\u8f83\u4f4e\u8017\u6c27\u91cf\u7684\u60c5\u51b5\u4e0b\u5b9e\u73b0\u9ad8ATP\u751f\u4ea7\u6548\u7387\u548c\u4f4e\u6c27\u5316\u5e94\u6fc0\u6c34\u5e73\uff0c\u5e76\u80fd\u6fc0\u6d3b\u7ecf\u5178\u7684\u7ebf\u7c92\u4f53PINK1\/Parkin\u81ea\u566c\u901a\u8def\u6d88\u9664Dox\u8bf1\u5bfc\u7684\u53d7\u635f\u7ebf\u7c92\u4f53\u5806\u79ef\uff0c\u534f\u8c03\u6c27\u5316\u5e94\u6fc0\u548c\u80fd\u91cf\u4ea7\u751f\u7684\u8c03\u8282\uff0c\u9010\u6b65\u6062\u590d\u5fc3\u810f\u5fae\u73af\u5883\u7684\u7a33\u6001\u3002\u4eba\u4eec\u8ba4\u4e3a\u706f\u76cf\u82b1\u7d20\u662f\u4e00\u79cd\u6f5c\u5728\u7684\u65b0\u578b\u4fdd\u62a4\u5242\uff0c\u53ef\u7528\u4e8e\u6cbb\u7597\u963f\u9709\u7d20\u5f15\u8d77\u7684\u5fc3\u810f\u6bd2\u6027\u3002<\/p>\n<\/div>\n<div id=\"s2\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"s2title\" class=\"head no_bottom_margin ui-helper-clearfix\">\u6750\u6599\u548c\u65b9\u6cd5<\/h2>\n<p class=\"p p-first\">\u6240\u6709\u52a8\u7269\u7814\u7a76\u5747\u7ecf\u9752\u5c9b\u5927\u5b66\u52a8\u7269\u62a4\u7406\u548c\u4f7f\u7528\u59d4\u5458\u4f1a\u7684\u6307\u5bfc\u65b9\u9488\u6279\u51c6\u5e76\u8fdb\u884c\u3002<\/p>\n<div id=\"s2-1\" class=\"sec\">\n<h3 id=\"s2-1title\">\u8bd5\u5242<\/h3>\n<p class=\"p p-first-last\">\u4f7f\u7528\u4ee5\u4e0b\u8bd5\u5242\uff1aDMEM\u3001FBS\u3001\u9752\u9709\u7d20\/\u94fe\u9709\u7d20\uff08\u7f8e\u4ed1\u751f\u7269\uff0c\u5927\u8fde\uff0c\u4e2d\u56fd\uff09\u3001cTnI Elisa \u8bd5\u5242\u76d2\uff08\u751f\u5de5\u751f\u7269\u79d1\u6280\uff0c\u4e0a\u6d77\uff0c\u4e2d\u56fd\uff09\u3001TNF-\u03b1\u3001IL-1\u03b2 \u548c IL-6 Elisa \u8bd5\u5242\u76d2\uff08MyBioSource\uff0c\u7f8e\u56fd\u5723\u5730\u4e9a\u54e5\uff09\u3001MDA \u8bd5\u5242\u76d2\u3001SOD \u8bd5\u5242\u76d2\u3001NADH \u8bd5\u5242\u76d2\uff08Solarbio\uff0c\u5317\u4eac\uff0c\u4e2d\u56fd\uff09\u3001CCK-8 \u8bd5\u5242\u76d2\uff08\u78a7\u9633\u5929\u751f\u7269\u79d1\u6280\uff0c\u4e2d\u56fd\u4e0a\u6d77\uff09\u3001ROS \u8367\u5149\u8bd5\u5242\u76d2\u3001JC-1 \u8367\u5149\u67d3\u6599\u3001\u86cb\u767d\u63d0\u53d6\u8bd5\u5242\u76d2\uff0c\u548cBCA\u8bd5\u5242\u76d2\uff08\u7f8e\u4f26\u751f\u7269\uff0c\u5927\u8fde\uff0c\u4e2d\u56fd\uff09\u3002 IL-1 (1:100)\u3001PINK1(1:1,000)\u3001Parkin (1:1,000)\u3001AMPK(1:1,000)\u3001Akt (1:1,000)\u3001P13K(1:1,000)\u3001Tom20 (1:1,000) \u3001\u03b2-\u5fae\u7ba1\u86cb\u767d (1:1,000)\u3001mTOR (1:1,000) \u548c HRP \u6807\u8bb0\u7684 GAPDH (1:1,000) \u6297\u4f53\u5747\u8d2d\u81ea Abclonal Biotechnology\uff08\u4e2d\u56fd\u6b66\u6c49\uff09\u3002 RIPA \u88c2\u89e3\u7f13\u51b2\u6db2\u548c\u4e0a\u6837\u7f13\u51b2\u6db2\u8d2d\u81ea\u7f8e\u4f26\u751f\u7269\uff08\u4e2d\u56fd\u5927\u8fde\uff09\u3002 PVDF \u819c\u8d2d\u81ea Merck\uff08\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\uff09\u3002 DMSO \u8d2d\u81ea Macklin\uff08\u4e2d\u56fd\u4e0a\u6d77\uff09\uff0c\u963f\u9709\u7d20\u3001\u706f\u76cf\u82b1\u7d20\u548c\u53f3\u96f7\u4f50\u751f\u8d2d\u81ea Widely\uff08\u4e2d\u56fd\u6b66\u6c49\uff09\u3002 Mdivi-1 \u6291\u5236\u5242\u8d2d\u81ea Selleck Chemicals\uff08\u7f8e\u56fd\u4f11\u65af\u987f\uff09\u3002<\/p>\n<\/div>\n<div id=\"s2-2\" class=\"sec\">\n<h3 id=\"s2-2title\">\u7ec6\u80de\u57f9\u517b\u6761\u4ef6\u548c\u7ec6\u80de\u7cfb<\/h3>\n<p class=\"p p-first\">\u7528\u4e8e\u7ec6\u80de\u57f9\u517b\u7684\u57f9\u517b\u57fa\u548c\u8865\u5145\u7269\u8d2d\u81ea Gibco-Invitrogen (Carlsbad, CA, United States)\uff0c\u5851\u6599\u5668\u76bf\u8d2d\u81ea Corning (Corning, NY, United States)\u3002 H9c2\u80da\u80ce\u5927\u9f20\u5fc3\u810f\u6765\u6e90\u7684\u5fc3\u808c\u7ec6\u80de\uff08ATCC\uff0cCRL-1446\uff09\u5728\u542b\u670910%\u80ce\u725b\u8840\u6e05\u3001100\u5355\u4f4d\/ml\u9752\u9709\u7d20G\u94a0\u548c100\u03bcg\/ml\u786b\u9178\u94fe\u9709\u7d20\u7684DMEM\u4e2d\u57f9\u517b\uff0837\u2103\uff0c5% CO<sub>2<\/sub>\uff09\u3002 MCF-7 \u4eba\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7ec6\u80de\uff08iCell\u3001iCell-h129\uff09\u5728\u8865\u5145\u6709 10% \u80ce\u725b\u8840\u6e05\u3001100 \u5355\u4f4d\/ml \u9752\u9709\u7d20 G \u94a0\u548c 100 \u03bcg\/ml \u786b\u9178\u94fe\u9709\u7d20\u7684 1,640 \u57f9\u517b\u57fa\u4e2d\u57f9\u517b\u3002 4T1\u5c0f\u9f20\u4e73\u817a\u764c\u7ec6\u80de\uff08ATCC\uff0cFS-0158\uff09\u5728\u8865\u5145\u670910%\u80ce\u725b\u8840\u6e05\u3001100\u5355\u4f4d\/ml\u9752\u9709\u7d20G\u94a0\u548c100\u03bcg\/ml\u786b\u9178\u94fe\u9709\u7d20\u7684DMEM\u57f9\u517b\u57fa\u4e2d\u57f9\u517b\u3002<\/p>\n<p class=\"p p-last\">\u5f53\u7ec6\u80de\u8fbe\u5230 80-90% \u6c47\u5408\u65f6\u5b9a\u671f\u4f20\u4ee3\uff0c\u5e76\u63a5\u79cd\u4e8e 96 \u5b54\u677f\uff081 \u00d7 10<sup>4<\/sup>\u00a0\u7ec6\u80de\/\u5b54\uff09\u3002 H9c2 \u7ec6\u80de\u66b4\u9732\u4e8e\u5bf9\u7167\uff0c5 \u03bcM Dox\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B12\" aria-expanded=\"false\" aria-haspopup=\"true\">\u90ed\u7b49\uff0c2013<\/a>), 5 \u03bcM Dox+20 \u03bcM Dexra (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B35\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6851\u7ef4\u5c3c\u7b49\u4eba\uff0c2020<\/a>), \u6216 5 \u03bcM Dox+200 \u03bcM \u706f\u76cf\u82b1\u7d20 (<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B22\" aria-expanded=\"false\" aria-haspopup=\"true\">\u674e\u7b49\u4eba\uff0c2022<\/a>\uff09\u5206\u522b\u4e3a24\u5c0f\u65f6\u3002\u4ec5\u7528DMEM\u5904\u7406\u7684\u7ec6\u80de\u4f5c\u4e3a\u7a7a\u767d\u5bf9\u7167\uff0cDexra\u4f5c\u4e3a\u9633\u6027\u5bf9\u7167\u3002\u6700\u540e\uff0c\u6211\u4eec\u8fd8\u6ce8\u5c04\u4e86 Mdivi-1\uff085\u03bcM\uff0c\u6eb6\u4e8e DMSO\uff09\uff0c\u4e00\u79cd\u7ebf\u7c92\u4f53\u5206\u88c2\u6291\u5236\u5242\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B30\" aria-expanded=\"false\" aria-haspopup=\"true\">Nhu \u7b49\u4eba\uff0c2021<\/a>).<\/p>\n<\/div>\n<div id=\"s2-3\" class=\"sec\">\n<h3 id=\"s2-3title\">\u6c27\u5316\u5e94\u6fc0\u8bc4\u4f30<\/h3>\n<p class=\"p p-first-last\">\u6839\u636e\u5236\u9020\u5546\u7684\u8bf4\u660e\uff0c\u4f7f\u7528\u8367\u5149\u67d3\u6599 DCFH-DA \u6d4b\u91cf\u7ec6\u80de\u5185 ROS \u6c34\u5e73\u3002\u7b80\u800c\u8a00\u4e4b\uff0c\u5728 PBS \u4e2d\u5236\u5907 DCFH-DA \u6eb6\u6db2 (1 \u03bcM)\uff0c\u5e76\u5c06\u5176\u6dfb\u52a0\u5230\u5728 6 \u5b54\u677f\u4e2d\u57f9\u517b\u7684 H9c2 \u7ec6\u80de\u4e2d\uff0c\u7136\u540e\u5728 37\u00b0C \u4e0b\u5b75\u80b2 30 \u5206\u949f\u3002\u5b75\u80b2\u540e\uff0c\u7528PBS\u6d17\u6da4\u7ec6\u80de\u3002\u4f7f\u7528 Leica Microsystems, Ltd. \u7684\u8367\u5149\u663e\u5fae\u955c\u4ee5 20 \u500d\u653e\u5927\u500d\u6570\u62cd\u6444\u8367\u5149\u663e\u5fae\u7167\u7247\u3002\u4f7f\u7528 Beckman \u6d41\u5f0f\u7ec6\u80de\u4eea\uff08\u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u8d1d\u514b\u66fc\uff09\u5bf9 ROS \u6c34\u5e73\u8fdb\u884c\u5b9a\u91cf\u3002<\/p>\n<\/div>\n<div id=\"s2-4\" class=\"sec\">\n<h3 id=\"s2-4title\">\u9176\u5b66\u6307\u6807\u7684\u6d4b\u5b9a<\/h3>\n<p class=\"p p-first-last\">SOD \u548c NADH \u7684\u6d3b\u6027\u6839\u636e\u5236\u9020\u5546\u7684\u8bf4\u660e\u4f7f\u7528\u6d3b\u6027\u6d4b\u5b9a\u8bd5\u5242\u76d2\u8fdb\u884c\u6d4b\u91cf\u3002\u4f7f\u7528\u9176\u6807\u4eea\uff08Perkin Elmer\uff0c\u9a6c\u8428\u8bf8\u585e\u5dde\uff0c\u7f8e\u56fd\uff09\u6d4b\u91cf\u5438\u5149\u5ea6\u548c\u53d1\u5149\u5ea6\u3002<\/p>\n<\/div>\n<div id=\"s2-5\" class=\"sec\">\n<h3 id=\"s2-5title\">\u7535\u5b50\u663e\u5fae\u955c<\/h3>\n<p class=\"p p-first-last\">\u5c06\u7ec6\u80de\u7528 0.5% \u620a\u4e8c\u919b\u56fa\u5b9a\u5242\u5728 4 \u00b0C \u4e0b\u56fa\u5b9a 15-30 \u5206\u949f\uff0c\u7136\u540e\u4ee5 10,000-13,000 rpm \u79bb\u5fc3 5 \u5206\u949f\u6536\u96c6\u7ec6\u80de\u3002\u5c06\u7ec6\u80de\u8fdb\u4e00\u6b65\u75283%\u620a\u4e8c\u919b\u57284\u2103\u4e0b\u56fa\u5b9a\u8fc7\u591c\uff0c\u7136\u540e\u75281%\u56db\u6c27\u5316\u9507\u5728\u5ba4\u6e29\u4e0b\u5904\u74062\u5c0f\u65f6\u3002\u6b64\u540e\uff0c\u5c06\u6837\u54c1\u5728\u4e19\u916e\u68af\u5ea6\u4e2d\u8131\u6c34\uff0c\u5305\u57cb\u5728Epon 812\u4e2d\uff0c\u8fdb\u884c\u5149\u5b66\u5b9a\u4f4d\uff0c\u5e76\u5207\u6210\u8d85\u8584\u5207\u7247\u3002\u5c06\u5207\u7247\u7528\u4e59\u9178\u53cc\u6c27\u94c0\u548c\u67e0\u6aac\u9178\u94c5\u8fdb\u884c\u53cc\u91cd\u67d3\u8272\u3002\u4f7f\u7528 H-7650 \u900f\u5c04\u7535\u5b50\u663e\u5fae\u955c\uff08\u65e5\u672c\u4e1c\u4eac\u65e5\u7acb\u516c\u53f8\uff09\u68c0\u67e5\u7ebf\u7c92\u4f53\u8d85\u5fae\u7ed3\u6784\u3002<\/p>\n<\/div>\n<div id=\"s2-6\" class=\"sec\">\n<h3 id=\"s2-6title\">\u7ebf\u7c92\u4f53\u547c\u5438\u7684\u6d4b\u5b9a<\/h3>\n<p class=\"p p-first-last\">\u7ea610<sup>6<\/sup>\u00a0\u4f7f\u7528 O2K \u547c\u5438\u8ba1\uff08Oroboros Instruments\uff0c\u5965\u5730\u5229\uff09\u6d4b\u91cf\u7ec6\u80de\u7684\u7ebf\u7c92\u4f53\u547c\u5438\u3002\u4f7f\u7528Oroboros DatLab 7.4\u8f6f\u4ef6\u6d4b\u5b9a\u548c\u5206\u6790\u6c27\u6d53\u5ea6\u3002\u7b80\u800c\u8a00\u4e4b\uff0c\u4ec5\u8bb0\u5f55\u7ec6\u80de\u4e2d\u7684\u6cc4\u6f0f\u547c\u5438\u72b6\u6001\uff0c\u901a\u8fc7\u6dfb\u52a0 5 mM ADP \u5c06\u7535\u5b50\u8f6c\u79fb\u4e0e\u78f7\u9178\u5316\u5076\u8054\uff0c\u5e76\u8bb0\u5f55\u590d\u5408\u7269 I \u652f\u6301\u7684\u72b6\u6001 3 \u547c\u5438\u3002\u901a\u8fc7\u6dfb\u52a0 10 mM \u7425\u73c0\u9178\u76d0\u8bb0\u5f55\u6765\u81ea\u590d\u5408\u7269 I \u548c\u590d\u5408\u7269 II \u7684\u5e73\u884c\u7535\u5b50\u8f93\u5165\u7684\u6700\u5927\u6001 3 \u547c\u5438\uff0c\u5e76\u5728 6.25 \u00b5M \u9c7c\u85e4\u916e\u5b58\u5728\u4e0b\u6d4b\u91cf\u590d\u5408\u7269 II \u652f\u6301\u7684\u547c\u5438\u3002\u5728 5 \u00b5M \u7fb0\u57fa\u6c30\u5316\u7269\u5bf9\uff08\u4e09\u6c1f\u7532\u6c27\u57fa\uff09\u82ef\u57fa\u8159 (FCCP) \u5b58\u5728\u4e0b\u8bb0\u5f55\u6700\u5927\u7535\u5b50\u8f6c\u79fb\u5bb9\u91cf\u3002\u6700\u540e\uff0c\u7ed9\u4e88\u6297\u9709\u7d20\uff08Ama\uff09\uff0c\u5176\u5b8c\u6210\u590d\u5408\u4f53\u2162\u5e76\u963b\u65ad\u6240\u6709\u7535\u5b50\u4f20\u9012\uff0c\u5e76\u6d4b\u91cf\u8017\u6c27\u7387\u4f5c\u4e3a\u975e\u7ebf\u7c92\u4f53\u8017\u6c27\u91cf\u3002<\/p>\n<\/div>\n<div id=\"s2-7\" class=\"sec\">\n<h3 id=\"s2-7title\">\u7ebf\u7c92\u4f53\u819c\u7535\u4f4d\u53d8\u5316\u7684\u6d4b\u5b9a (\u0394\u03a8m)<\/h3>\n<p class=\"p p-first-last\">\u4f7f\u7528 5.5&#039;,6.6&#039;-\u56db\u6c2f-1.1&#039;,3.3&#039;-\u56db\u4e59\u57fa\u82ef\u5e76\u54aa\u5511\u57fa\u7898\u5316\u78b3\u82b1\u9752 (JC-1) \u67d3\u8272\u6765\u8bc4\u4f30 H9c2 \u7ec6\u80de\u4e2d\u7684\u7ebf\u7c92\u4f53\u819c\u7535\u4f4d\u3002\u7b80\u800c\u8a00\u4e4b\uff0c\u6839\u636e\u9884\u5b9a\u7684\u5b9e\u9a8c\u6761\u4ef6\uff0c\u7528\u6e29\u70ed\u7684\u675c\u5c14\u8d1d\u79d1\u78f7\u9178\u76d0\u7f13\u51b2\u76d0\u6c34\uff08DPBS\uff09\u6d17\u6da4H9c2\u7ec6\u80de\uff0c\u7136\u540e\u7528100\u03bcL 2\u03bcM JC-1\u6eb6\u6db2\uff08\u5728\u4e0d\u542b\u915a\u7ea2\u7684DMEM\u4e2d\u6df7\u5408\uff09\u67d3\u8272\u5e76\u5728\u6807\u51c6\u7ec6\u80de\u57f9\u517b\u7269\u4e0b\u5b75\u80b2\u6761\u4ef6\u4e0b\u5728\u9ed1\u6697\u4e2d\u653e\u7f6e 30 \u5206\u949f\u3002\u5b75\u80b2\u540e\uff0c\u7528\u6e29\u70ed\u7684 DPBS \u6d17\u6da4\u7ec6\u80de\uff0c\u5e76\u4f7f\u7528 Leica Microsystems CMS GmbH \u5012\u7f6e\u8367\u5149\u663e\u5fae\u955c\uff08Leica Camera AG\uff0cBarnack\uff0c\u5fb7\u56fd\uff09\u5728 20 \u500d\u653e\u5927\u500d\u6570\u4e0b\u62cd\u6444\u8367\u5149\u663e\u5fae\u7167\u7247\u3002<\/p>\n<\/div>\n<div id=\"s2-8\" class=\"sec\">\n<h3 id=\"s2-8title\">\u514d\u75ab\u8367\u5149<\/h3>\n<p class=\"p p-first-last\">\u4e3a\u4e86\u8bc4\u4f30\u7ebf\u7c92\u4f53\u5b9a\u4f4d\uff0c\u7528\u51b7 PBS \u6e05\u6d17\u76d6\u73bb\u7247\u4e0a\u751f\u957f\u7684\u7ec6\u80de\uff0c\u5e76\u7528 4% \u591a\u805a\u7532\u919b\u56fa\u5b9a 15 \u5206\u949f\u3002\u7136\u540e\uff0c\u75280.5% Triton X-100\u900f\u5316\u7ec6\u80de20\u5206\u949f\uff0c\u5e76\u75285%\u5c71\u7f8a\u8840\u6e05\u5c01\u95ed30\u5206\u949f\u3002\u5c06\u7ec6\u80de\u4e0e\u4e00\u6297\u5728 4\u00b0C \u5b75\u80b2\u8fc7\u591c\uff0c\u5e76\u4e0e\u4e8c\u6297\u5b75\u80b2 1 \u5c0f\u65f6\u3002\u6d17\u6da43\u6b21\u540e\uff0c\u75284&#039;-6-\u4e8c\u8112\u57fa-2-\u82ef\u57fa\u5432\u54da\uff08DAPI\uff09\u5bf9\u7ec6\u80de\u8fdb\u884c\u67d3\u8272\uff0c\u5e76\u7528\u5171\u7126\u6fc0\u5149\u626b\u63cf\u663e\u5fae\u955c\u6210\u50cf\u3002<\/p>\n<\/div>\n<div id=\"s2-9\" class=\"sec\">\n<h3 id=\"s2-9title\">ATP\u6d4b\u91cf<\/h3>\n<p class=\"p p-first-last\">\u6b64\u5916\uff0c\u6309\u7167\u5236\u9020\u5546\u7684\u65b9\u6848\u4f7f\u7528 ATP \u6d4b\u5b9a\u8bd5\u5242\u76d2\u6d4b\u91cf\u7ec6\u80de\u5185 ATP \u6d53\u5ea6\u3002\u901a\u8fc7\u91cd\u590d\u79fb\u6db2\u5c06\u7ec6\u80de\u5728\u88c2\u89e3\u7f13\u51b2\u6db2\u4e2d\u88c2\u89e3\uff0c\u5e76\u5728 4\u00b0C \u548c 13,000 g \u4e0b\u79bb\u5fc3 10 \u5206\u949f\u3002\u4e0a\u6e05\u6db2\u7528\u4e8e\u5206\u6790 ATP \u6c34\u5e73\uff0c\u5e76\u901a\u8fc7 BCA \u6d4b\u5b9a\u6d4b\u5b9a\u86cb\u767d\u8d28\u6d53\u5ea6\u3002\u5c0650\u5fae\u5347\u4e0a\u6e05\u6db2\u52a0\u5165100\u03bcl ATP\u68c0\u6d4b\u6db2\u4e2d\uff0c\u5ba4\u6e29\u5b75\u80b25min\uff0c\u7acb\u5373\u6df7\u5300\uff0c\u7528\u5149\u5ea6\u8ba1\uff08Flex Station 3\uff09\u6d4b\u5b9a\u53d1\u5149\u3002\u6839\u636e\u6807\u51c6\u66f2\u7ebf\u8ba1\u7b97ATP\u6d53\u5ea6\u5e76\u6362\u7b97\u6210nmol\/\u03bcg\u86cb\u767d\u8d28\u3002<\/p>\n<\/div>\n<div id=\"s2-10\" class=\"sec\">\n<h3 id=\"s2-10title\">\u86cb\u767d\u8d28\u5370\u8ff9\u6cd5<\/h3>\n<p class=\"p p-first-last\">\u901a\u8fc7\u86cb\u767d\u8d28\u5370\u8ff9\u8bc4\u4f30\u86cb\u767d\u8d28\u8868\u8fbe\u5e76\u901a\u8fc7\u5149\u5bc6\u5ea6\u6d4b\u5b9a\u6cd5\u5b9a\u91cf\u3002\u4f7f\u7528 RIPA \u88c2\u89e3\u7f13\u51b2\u6db2\u88c2\u89e3 10 cm \u7ec6\u80de\u57f9\u517b\u76bf\u4e2d\u7684 Dox \u548c Dox + Brev \u5904\u7406\u7684 H9c2 \u7ec6\u80de\u3002\u53d6 5 mg \u7ec4\u7ec7\uff0c\u52a0\u5165 10 ml \u88c2\u89e3\u7f13\u51b2\u6db2\u3002 Bradford\u6cd5\u7528\u4e8e\u6d4b\u91cf\u86cb\u767d\u8d28\u6d53\u5ea6\uff0c\u4ee5BSA\u4e3a\u6807\u51c6\u3002\u5c06\u7b49\u91cf\u7684\u86cb\u767d\u8d28\u4e0e\u4e0a\u6837\u7f13\u51b2\u6db2 (5X) \u6df7\u5408\uff0c\u5e76\u5728 95\u00b0C \u4e0b\u716e\u6cb8 5 \u5206\u949f\u3002\u7136\u540e\u901a\u8fc7 10%\u201312% SDS-\u805a\u4e19\u70ef\u9170\u80fa\u51dd\u80f6 (SDS-PAGE) \u7535\u6cf3\u89e3\u6790\u86cb\u767d\u8d28\u5e76\u8f6c\u79fb\u5230 PVDF \u819c\u4e0a\u3002\u7528 TBST \u4e2d\u7684 5% \u725b\u5976\u5728\u5ba4\u6e29\u4e0b\u5c01\u95ed 2 \u5c0f\u65f6\u540e\uff0c\u5c06\u819c\u4e0e\u7279\u5f02\u6027\u6297\u4f53\uff08\u4f8b\u5982\u5154\u591a\u514b\u9686 GAPDH\uff09\u5728 4\u00b0C \u4e0b\u5b75\u80b2\u8fc7\u591c\u3002\u4f7f\u7528\u9488\u5bf9 AMPK\u3001Parkin\u3001PINK1\u3001Akt\u3001PI3K\u3001Tom20 \u7684\u6297\u4f53\u5bf9\u86cb\u767d\u8d28\u8868\u8fbe\u548c\u78f7\u9178\u5316\u8fdb\u884c WB \u5206\u6790\uff0c\u5e76\u4f7f\u7528 GAPDH \u4f5c\u4e3a\u5185\u90e8\u5bf9\u7167\u3002\u4f7f\u7528 Bio-Rad \u51dd\u80f6\u6587\u6863\u7cfb\u7edf\uff08Bio-Rad Laboratories\uff0c\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\uff0c\u7f8e\u56fd\uff09\u5bf9\u7279\u5b9a\u4fe1\u53f7\u8fdb\u884c\u53ef\u89c6\u5316\u3002\u6570\u636e\u8868\u793a\u4e3a\u5e73\u5747\u503c\u00b1SD\uff08<em>n<\/em>\u00a0= 3) \u5e76\u901a\u8fc7 ImageJ \u5206\u6790\u8fdb\u884c\u91cf\u5316\u3002<\/p>\n<\/div>\n<div id=\"s2-11\" class=\"sec\">\n<h3 id=\"s2-11title\">\u755c\u7267\u4e1a<\/h3>\n<p class=\"p p-first\">\u5b9e\u9a8c\u4f7f\u7528\u516b\u5468\u9f84\u96cc\u6027 C57BL\/6 \u5c0f\u9f20\uff08\u4e2d\u56fd\u5317\u4eac\u56db\u57f9\u798f\uff09\u3002\u5c06\u52a8\u7269\u9972\u517b\u5728\u7b3c\u5b50\u4e2d\uff0c\u5e76\u5728 50% \u6e7f\u5ea6\u548c 25\u00b0C \u00b1 2\u00b0C \u4e0b\u8fdb\u884c 12 \u5c0f\u65f6\u5149\u7167\/12 \u5c0f\u65f6\u9ed1\u6697\u5faa\u73af\u3002\u52a8\u7269\u53ef\u4ee5\u81ea\u7531\u83b7\u53d6\u6807\u51c6\u9897\u7c92\u9972\u6599\u548c\u6c34\u3002\u901a\u8fc7\u5728 4\u00b0C \u4e0b\u4ee5 200 g \u79bb\u5fc3 10 \u5206\u949f\u83b7\u5f97\u8840\u6d46\uff0c\u5e76\u5728\u63d0\u53d6\u524d\u4fdd\u6301\u5728 -80\u00b0C\u3002<\/p>\n<p class=\"p p-last\">\u8c03\u67e5\u7b26\u5408\u00a0<em>\u5b9e\u9a8c\u52a8\u7269\u62a4\u7406\u548c\u4f7f\u7528\u6307\u5357<\/em>\u00a0\u7531\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u51fa\u7248\uff08NIH \u51fa\u7248\u7269\u7b2c 85-23 \u53f7\uff0c1985 \u5e74\u4fee\u8ba2\uff09\u3002<\/p>\n<\/div>\n<div id=\"s2-12\" class=\"sec\">\n<h3 id=\"s2-12title\">\u52a8\u7269\u5b9e\u9a8c\u65b9\u6848<\/h3>\n<p class=\"p p-first\">\u5c06\u5c0f\u9f20\u968f\u673a\u5206\u4e3a6\u4e2a\u6cbb\u7597\u7ec4\uff0c\u5305\u62ec\u5bf9\u7167\u7ec4\u3001\u6a21\u578b\u7ec4\uff08Dox\u7ec4\uff09\u3001\u4e09\u5242\u91cfDox+Brev\u7ec4\u548cDox+Dexra\u7ec4\u3002<\/p>\n<p>\u4e3a\u4e86\u6a21\u4eff\u4eba\u7c7b\u6cbb\u7597\u65b9\u6848\uff0c\u65bd\u7528\u7d2f\u79ef\u5242\u91cf\u4e3a 12 mg\/kg \u7684 Dox\u00a0<em>\u901a\u8fc7<\/em>\u00a0\u9664\u5bf9\u7167\u7ec4\u5916\uff0c\u6bcf\u5468 3 \u6b21 ip \u6ce8\u5c04\uff08\u7b2c 0\u30017 \u548c 14 \u5929 4 mg\/kg\uff09\u3002<\/p>\n<p>\u7814\u7a76 Brev \u7684\u6548\u679c\u00a0<em>\u4f53\u5185\uff0c<\/em>\u00a0\u5c0f\u9f20\u63a5\u53d7Brev\u6cbb\u7597\uff0c\u968f\u540e\u6bcf\u65e5\u8179\u8154\u6ce8\u5c044.8\u548c16 mg\/kg\u7684Brev\uff0c\u6301\u7eed3\u5468\uff1bDox + Dexra\u6cbb\u7597\u7ec4\u7684\u5c0f\u9f20\u9664Dox\u5916\u8fd8\u63a5\u53d7\u8179\u8154\u6ce8\u5c0412 mg\/kg Dexra\uff0c\u6301\u7eed3\u5468\u3002\u6cbb\u7597\u3002 \uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B1\" aria-expanded=\"false\" aria-haspopup=\"true\">\u4e9a\u5386\u5c71\u5927\u7b49\u4eba\uff0c2020<\/a>\uff09\u3002 Brev \u548c Dexra \u5728\u6ce8\u5c04 Dox \u540e\u63a5\u53d7\u6cbb\u7597\u3002\u9996\u6b21\u6ce8\u5c04 Dox \u540e 3 \u5468\uff0c\u6bcf\u65e5\u76d1\u6d4b\u5b58\u6d3b\u7387\u5e76\u901a\u8fc7\u8d85\u58f0\u5fc3\u52a8\u56fe\u8bc4\u4f30\u5fc3\u810f\u529f\u80fd\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B21\" aria-expanded=\"false\" aria-haspopup=\"true\">\u674e\u7b49\u4eba\uff0c2018<\/a>).<\/p>\n<p class=\"p p-last\">\u5bf9\u7167\u7ec4\u6ce8\u5c04\u7b49\u4f53\u79ef\u7684\u751f\u7406\u76d0\u6c34\u3002\u65bd\u7528 Dox \u540e 1 \u5468\u5904\u6b7b\u5c0f\u9f20\u3002<\/p>\n<\/div>\n<div id=\"s2-13\" class=\"sec\">\n<h3 id=\"s2-13title\">\u80bf\u7624\u7814\u7a76<\/h3>\n<p class=\"p p-first-last\">\u5c0f\u9f20\u76ae\u4e0b\u6ce8\u5c041\u00d710<sup>5<\/sup>\u00a04T1\u4e73\u817a\u80bf\u7624\u7ec6\u80de\u3002\u7ec6\u80de\u6ce8\u5c04\u4e00\u5468\u540e\uff0c\u5f53\u80bf\u7624\u7684\u5e73\u5747\u76f4\u5f84\u5927\u4e8e2\u6beb\u7c73\u65f6\uff0c\u5982\u524d\u6240\u8ff0\u7528Dox\u6216\u706f\u76cf\u82b1\u7d20\u6cbb\u7597\u5c0f\u9f20\u3002\u6bcf\u5468\u6d4b\u91cf\u4e24\u6b21\u80bf\u7624\u5927\u5c0f\uff0c\u6301\u7eed\u957f\u8fbe 4 \u5468\uff0c\u5e76\u4f7f\u7528\u4ee5\u4e0b\u516c\u5f0f\u8ba1\u7b97\u80bf\u7624\u4f53\u79ef\uff1aV = 4\u03c0\/3\u00d7(L\/2)2\u00d7(W\/2)\uff0c\u5176\u4e2d V\u3001L \u548c W \u4ee3\u8868\u5206\u522b\u662f\u80bf\u7624\u7684\u4f53\u79ef\u3001\u957f\u5ea6\u548c\u5bbd\u5ea6\u3002<\/p>\n<\/div>\n<div id=\"s2-14\" class=\"sec\">\n<h3 id=\"s2-14title\"><sup>18<\/sup>F-\u6c1f\u8131\u6c27\u8461\u8404\u7cd6 PET\/CT \u6210\u50cf<\/h3>\n<p class=\"p p-first-last\">Dox \u548c\u706f\u76cf\u82b1\u7d20\u7ec4\u5c0f\u9f20\uff08\u7981\u98df\u8fc7\u591c\uff09\u7528 2% \u5f02\u6c1f\u70f7\u9ebb\u9189\uff0c\u5e76\u6ce8\u5c04 \u223c11MBq\/0.2 ml \u6c1f\u8131\u6c27\u8461\u8404\u7cd6 (FDG) PET\u00a0<em>\u901a\u8fc7<\/em>\u00a0\u5c3e\u9759\u8109\uff0c\u7136\u540e\u8fd4\u56de\u7b3c\u5b50\u3002\u56db\u5341\u5206\u949f\u540e\uff0c\u518d\u6b21\u7528 2% \u5f02\u6c1f\u70f7\u9ebb\u9189\u5c0f\u9f20\uff0c\u5e76\u5c06\u5176\u653e\u7f6e\u5728 microPET Focus 220\uff08\u5fb7\u56fd\u67cf\u6797\u897f\u95e8\u5b50\u516c\u53f8\uff09\u7684\u7acb\u4f53\u5b9a\u5411\u5e8a\u4e0a\u3002\u7136\u540e\u5f00\u59cb 20 \u5206\u949f\u9759\u6001 PET \u626b\u63cf\u3002\u968f\u540e\uff0c\u5c0f\u9f20\u5728 microCAT II\uff08\u897f\u95e8\u5b50\u516c\u53f8\uff0c\u67cf\u6797\uff0c\u5fb7\u56fd\uff09\u4e2d\u4ee5 180mAs \u7684 X \u5c04\u7ebf\u675f\u5f3a\u5ea6\u548c 80 kVp \u7684 X \u5c04\u7ebf\u7ba1\u7535\u538b\u5bf9\u5c0f\u9f20\u8fdb\u884c\u6210\u50cf\uff0c\u4ee5\u4fbf\u4e0e PET \u56fe\u50cf\u8fdb\u884c\u89e3\u5256\u5b66\u5171\u540c\u914d\u51c6\u3002<\/p>\n<\/div>\n<div id=\"s2-15\" class=\"sec\">\n<h3 id=\"s2-15title\">\u60a3\u8005<\/h3>\n<p class=\"p p-first-last\">\u7981\u98df4\u5c0f\u65f6\u4ee5\u4e0a\u5e76\u786e\u4fdd\u8840\u7cd6\u6c34\u5e73\u4f4e\u4e8e120 mg\/dl\u540e\uff0c\u6240\u6709\u60a3\u8005\u5747\u63a5\u53d7\u9759\u8109\u6ce8\u5c04\u00a0<sup>18<\/sup>F-FDG (5.5 MBq\/kg)\u3002\u6ce8\u5c04\u540e 60 \u5206\u949f\u5f00\u59cb\u4f7f\u7528\u7ec4\u5408 PET\/CT \u4f20\u8bb0\u4eea\uff08\u5fb7\u56fd\u67cf\u6797\u897f\u95e8\u5b50\u516c\u53f8\uff09\u8fdb\u884c PET\/CT \u626b\u63cf\u3002\u6240\u6709\u626b\u63cf\u5747\u5728\u4e09\u7ef4\u6a21\u578b\u4e2d\u8fdb\u884c\u3002\u9996\u5148\u8fdb\u884c\u4f4e\u5242\u91cf CT \u626b\u63cf\u4ee5\u8fdb\u884c\u8870\u51cf\u6821\u6b63\u548c\u89e3\u5256\u76f8\u5173\u6027\u3002\u4f26\u7406\u5ba1\u67e5\u7b26\u5408\u9752\u5c9b\u5927\u5b66\u9644\u5c5e\u533b\u9662\u516c\u5e03\u7684\u300a\u4f26\u7406\u59d4\u5458\u4f1a\u5ba1\u6279\u6587\u4ef6\u6307\u5357\u300b\uff08QDU-HEC-2022057\uff09\u3002<\/p>\n<\/div>\n<div id=\"s2-16\" class=\"sec\">\n<h3 id=\"s2-16title\">\u5fc3\u529f\u80fd\u548c\u7ec4\u7ec7\u75c5\u7406\u5b66\u5206\u6790<\/h3>\n<p class=\"p p-first-last\">\u5c06\u5404\u7ec4\u5c0f\u9f20\u5fc3\u810f\u7ec4\u7ec7\u4fdd\u5b58\u4e8e4%\u591a\u805a\u7532\u919b\u4e2d\uff0c\u5305\u57cb\u4e8e\u77f3\u8721\u4e2d\uff0c\u8fde\u7eed\u5207\u62104mm\u5207\u7247\u3002\u7ec4\u7ec7\u5207\u7247\u8131\u8721\u00a0<em>\u901a\u8fc7<\/em>\u00a0\u6d78\u6ce1\u5728\u4e8c\u7532\u82ef\u4e2d\uff083\u6b21\uff0c\u6bcf\u6b215\u5206\u949f\uff09\uff0c\u5e76\u4f7f\u7528\u9012\u51cf\u7cfb\u5217\u7684\u9187\uff08100%\u300190%\u300185%\u548c75%\u9152\u7cbe\uff0c\u6bcf\u6b215\u5206\u949f\uff09\u518d\u6c34\u5316\u3002\u5c06\u5207\u7247\u7528\u82cf\u6728\u7cbe\u548c\u66d9\u7ea2\u67d3\u8272\u7528\u4e8e\u7ec4\u7ec7\u5b66\u5206\u6790\u3002\u4f7f\u7528\u9a6c\u68ee\u4e09\u8272\u67d3\u8272\u5242\u5bf9\u6d3b\u68c0\u6837\u672c\u8fdb\u884c\u67d3\u8272\uff0c\u4ee5\u7814\u7a76\u5fc3\u810f\u7684\u4efb\u4f55\u5f62\u6001\u548c\u7ea4\u7ef4\u5316\u53d8\u5316\u3002\u84dd\u8272\u67d3\u8272\u4ee3\u8868\u80f6\u539f\u86cb\u767d\u79ef\u7d2f\u3002\u6839\u636e\u5236\u9020\u5546\u7684\u8bf4\u660e\uff0c\u4f7f\u7528 Histone Simple \u67d3\u8272\u8bd5\u5242\u76d2\uff08Nichirei\uff0cTokyo\uff0cJapan\uff09\u8fdb\u884c\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u3002\u5c06\u5207\u7247\u7528\u7532\u9187\u4e2d\u7684 3% H2O2 \u5904\u7406 15 \u5206\u949f\u4ee5\u706d\u6d3b\u5185\u6e90\u8fc7\u6c27\u5316\u7269\u9176\uff0c\u7136\u540e\u4e0e\u4e00\u6297 IL-1\uff081:100\uff09\u5728\u5ba4\u6e29\u4e0b\u5b75\u80b2 1 \u5c0f\u65f6\u3002\u7136\u540e\u4f7f\u7528 Leica Microsystems \u7684 CMS GmbH \u5012\u7f6e\u8367\u5149\u663e\u5fae\u955c\uff08Leica Camera AG\uff0cBarnack\uff0c\u5fb7\u56fd\uff09\u5728 20 \u500d\u653e\u5927\u500d\u6570\u4e0b\u89c2\u5bdf\u8d85\u5fae\u7ed3\u6784\u3002<\/p>\n<\/div>\n<div id=\"s2-17\" class=\"sec\">\n<h3 id=\"s2-17title\">\u8840\u7cd6\u6c34\u5e73\u7684\u6d4b\u91cf<\/h3>\n<p class=\"p p-first\">\u5c0f\u9f20\u7ef4\u6301\u6b63\u5e38\u996e\u98df\u3002\u5b9e\u9a8c\u5f53\u5929\uff0c\u5c0f\u9f20\u7981\u98df6\u5c0f\u65f6\uff08\u4e0a\u53488\u70b9\u5f00\u59cb\uff09\uff0c\u5e76\u91c7\u8840\u00a0<em>\u901a\u8fc7<\/em>\u00a0\u5c3e\u9759\u8109\u7528\u4e8e\u6d4b\u91cf\u8461\u8404\u7cd6\u6c34\u5e73\u3002<\/p>\n<p class=\"p p-last\">H9c2\u5927\u9f20\u5fc3\u808c\u7ec6\u80de\u7528\u78f7\u9178\u76d0\u7f13\u51b2\u76d0\u6c34\uff08PBS\uff09\u6d17\u6da4\u5e76\u79bb\u5fc3\u5e76\u8d85\u58f0\u7834\u788e\uff0c\u5e76\u5728\u6807\u51c6\u7ec6\u80de\u57f9\u517b\u6761\u4ef6\u4e0b\u5b75\u80b210\u5206\u949f\u3002\u5b75\u80b2\u540e\uff0c\u4f7f\u7528\u9176\u6807\u4eea\uff08Perkin Elmer\uff0c\u9a6c\u8428\u8bf8\u585e\u5dde\uff0c\u7f8e\u56fd\uff09\u6d4b\u91cf\u5438\u5149\u5ea6\u3002<\/p>\n<\/div>\n<div id=\"s2-18\" class=\"sec\">\n<h3 id=\"s2-18title\">\u9176\u8054\u514d\u75ab\u5438\u9644\u6d4b\u5b9a<\/h3>\n<p class=\"p p-first-last\">\u7528\u88c2\u89e3\u7f13\u51b2\u6db2\u88c2\u89e3\u5c0f\u9f20\u7ec4\u7ec7\u3002\u4f7f\u7528 Qsonica \u5300\u6d46\u5668\u4f7f\u7528 30 Hz \u8109\u51b2\u5bf9\u6837\u54c1\u8fdb\u884c\u8d85\u58f0\u5904\u7406 20 \u79d2\uff0c\u7136\u540e\u4ee5 12,000 g \u79bb\u5fc3 10 \u5206\u949f\u3002\u6536\u96c6\u4e0a\u6e05\u6db2\uff0c\u7b49\u5206\u81f3 200 \u00b5l \u5c0f\u74f6\u4e2d\uff0c\u5e76\u4fdd\u5b58\u5728 -80\u00b0C \u4e0b\u3002\u901a\u8fc7 BCA \u6d4b\u5b9a\u5bf9\u6837\u54c1\u7684\u86cb\u767d\u8d28\u6d53\u5ea6\u8fdb\u884c\u5b9a\u91cf\u3002\u6839\u636e\u5236\u9020\u5546\u7684\u65b9\u6848\uff0c\u4f7f\u7528\u9176\u8054\u514d\u75ab\u5438\u9644\u6d4b\u5b9a\u8bd5\u5242\u76d2\u5bf9\u6837\u54c1\u8fdb\u884c TNF-\u03b1\u3001IL-1\u03b2 \u548c IL-6 \u5206\u6790\u3002\u4f7f\u7528 VICTOR Nivo\u2122 \u9176\u6807\u4eea\uff08Perkin Elmer\uff0c\u9a6c\u8428\u8bf8\u585e\u5dde\uff0c\u7f8e\u56fd\uff09\u5728 450 nm \u5904\u6d4b\u91cf\u5149\u5bc6\u5ea6\u3002<\/p>\n<\/div>\n<div id=\"s2-19\" class=\"sec\">\n<h3 id=\"s2-19title\">\u5c0f\u9f20\u4ee3\u8c22\u7ec4\u53d8\u5316\u7684\u6d4b\u5b9a<\/h3>\n<p class=\"p p-first-last\">\u8840\u6837\u91cd\u60ac\uff0c\u51b0\u4e0a\u5b75\u80b2\uff0c\u79bb\u5fc3\uff0c\u7a00\u91ca\u81f3\u7ec8\u6d53\u5ea6\uff0c\u79bb\u5fc3\u3002\u6700\u540e\uff0c\u5c06\u4e0a\u6e05\u6db2\u6ce8\u5165LC-MS\/MS\u7cfb\u7edf\u8fdb\u884c\u5206\u6790\u3002\u4f7f\u7528 Vanquish UHPLC \u7cfb\u7edf\uff08Thermo Fisher\uff0c\u9a6c\u8428\u8bf8\u585e\u5dde\uff0c\u7f8e\u56fd\uff09\u548c Orbitrap Q Exactive \u8fdb\u884c UHPLC-MS\/MS \u5206\u6790<sup>TM\u503c<\/sup>\u00a0HF \u8d28\u8c31\u4eea\uff08Thermo Fisher\uff0c\u9a6c\u8428\u8bf8\u585e\u5dde\uff0c\u7f8e\u56fd\uff09\u3002\u4f7f\u7528 KEGG \u6570\u636e\u5e93\u3001HMDB \u6570\u636e\u5e93\u548c LIPID Maps \u6570\u636e\u5e93\u5bf9\u9274\u5b9a\u7684\u4ee3\u8c22\u7269\u8fdb\u884c\u6ce8\u91ca\u3002\u4f7f\u7528metaX\u8fdb\u884c\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u548c\u504f\u6700\u5c0f\u4e8c\u4e58\u5224\u522b\u5206\u6790\uff08PLS-DA\uff09\u3002\u6211\u4eec\u5e94\u7528\u5355\u53d8\u91cf\u5206\u6790\uff08<em>t<\/em>-test\uff09\u8ba1\u7b97\u7edf\u8ba1\u663e\u7740\u6027\uff08<em>p<\/em>-\u4ef7\u503c\uff09\u3002 VIP&gt;1 \u7684\u4ee3\u8c22\u7269\uff0c\u00a0<em>p<\/em>\u00a0\u503c&lt;0.05\uff0c\u500d\u6570\u53d8\u5316\u22652\u6216\u22640.5\u88ab\u8ba4\u4e3a\u662f\u5dee\u5f02\u4e30\u5ea6\u4ee3\u8c22\u7269\u3002<\/p>\n<\/div>\n<div id=\"s2-20\" class=\"sec sec-last\">\n<h3 id=\"s2-20title\">\u7edf\u8ba1\u5206\u6790<\/h3>\n<p class=\"p p-first-last\">\u4f7f\u7528 ANOVA \u548c IBM SPSS Statistics\uff08V19.0\uff0c\u7f8e\u56fd\uff09\u8fdb\u884c\u7edf\u8ba1\u5206\u6790\u3002\u6570\u636e\u8868\u793a\u4e3a\u5e73\u5747\u503c\u00b1SD\uff08<em>n<\/em>\u00a0= 6\u20139)\u3002\u00a0<em>p<\/em>\u00a0&lt; 0.05 \u88ab\u8ba4\u4e3a\u662f\u663e\u7740\u7684\u3002<\/p>\n<\/div>\n<\/div>\n<div id=\"s3\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"s3title\" class=\"head no_bottom_margin ui-helper-clearfix\">\u7ed3\u679c<\/h2>\n<div id=\"s3-1\" class=\"sec sec-first\">\n<h3 id=\"s3-1title\">\u84bd\u73af\u7c7b\u836f\u7269\u964d\u4f4e\u5fc3\u808c\u8461\u8404\u7cd6\u4ee3\u8c22\u5e76\u589e\u52a0\u8102\u80aa\u9178\u5229\u7528\u7387<\/h3>\n<p class=\"p p-first\">\u6211\u4eec\u9996\u5148\u7814\u7a76\u7684\u662f\u00a0<sup>18<\/sup>\u63a5\u53d7\u84bd\u73af\u7c7b\u5316\u7597\u60a3\u8005\u548c\u672a\u63a5\u53d7\u5316\u7597\u60a3\u8005\u5fc3\u810f\u7684 18F-FDG PET\/CT \u56fe\u50cf\uff0c\u6570\u636e\u5206\u6790\u663e\u793a\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F1\/\" target=\"figure\" rel=\"noopener\">\u56fe1A<\/a>\uff09\u63a5\u53d7\u5316\u7597\u7684\u60a3\u8005\u5fc3\u808c\u8461\u8404\u7cd6\u6444\u53d6\u5448\u51cf\u5c11\u8d8b\u52bf\u3002\u6211\u4eec\u9884\u6d4b\u8be5\u53c2\u6570\u7684\u53d8\u5316\u53ef\u80fd\u4e0e\u84bd\u73af\u7c7b\u836f\u7269\u5f15\u8d77\u7684\u5fc3\u810f\u6bd2\u6027\u6709\u5173\u3002\u4e3a\u4e86\u9a8c\u8bc1\u4ee3\u8c22\u5f02\u5e38\u4e0e DIC \u4e4b\u95f4\u7684\u5185\u5728\u8054\u7cfb\uff0c\u6211\u4eec\u5efa\u7acb\u4e86 Dox \u8bf1\u5bfc\u7684 DIC \u5c0f\u9f20\u6a21\u578b\uff0c\u5e76\u00a0<sup>18<\/sup>F-FDG PET \u7ed3\u679c\u663e\u793a\uff0c4 \u5468\u540e\uff0cDox \u6cbb\u7597\u5c0f\u9f20\u7684\u5fc3\u810f\u6444\u53d6\u91cf\u663e\u7740\u4f4e\u4e8e\u672a\u6cbb\u7597\u5c0f\u9f20\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F1\/\" target=\"figure\" rel=\"noopener\">\u56fe1B<\/a>\uff09\u3002\u8fd9\u8868\u660e\u84bd\u73af\u7c7b\u836f\u7269\u5f71\u54cd\u60a3\u8005\u548c\u5c0f\u9f20\u6a21\u578b\u7684\u5fc3\u808c\u8461\u8404\u7cd6\u4ee3\u8c22\u3002<\/p>\n<div id=\"F1\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm139983198938400\">\n<div class=\"ts_bar small\" title=\"\u70b9\u51fb\u56fe\u7247\u653e\u5927\"><\/div>\n<p><a class=\"inline_block ts_canvas\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/core\/lw\/2.0\/html\/tileshop_pmc\/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&amp;p=PMC3&amp;id=9551275_fphar-13-930835-g001.jpg\" target=\"tileshopwindow\" rel=\"noopener\"><img decoding=\"async\" class=\"tileshop\" title=\"\u70b9\u51fb\u56fe\u7247\u653e\u5927\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/bin\/fphar-13-930835-g001.jpg\" alt=\"An external file that holds a picture, illustration, etc.Object name is fphar-13-930835-g001.jpg\" \/><\/a><\/div>\n<div id=\"lgnd_F1\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F1\/\" target=\"figure\" rel=\"noopener\">\u56fe1<\/a><\/div>\n<div class=\"caption\">\n<p><strong>\uff08A\uff09<\/strong>\u00a0\u6d53\u5ea6\u00a0<sup>18<\/sup>\u63a5\u53d7\u5316\u7597\u548c\u672a\u63a5\u53d7\u5316\u7597\u7684\u60a3\u8005\u7684\u5fc3\u810f\u5438\u6536 F-FDG\u3002\u00a0<strong>(\u4e8c)<\/strong>\u00a0<sup>18<\/sup>F-FDG PET\/CT \u56fe\u50cf\u91c7\u96c6\u548c\u5fc3\u810f\u00a0<sup>18<\/sup>F-FDG \u5438\u6536\u3002\u00a0<strong>\uff08C\uff09<\/strong>\u00a0Dox \u6cbb\u7597\u5c0f\u9f20\u7684\u70ed\u56fe\u3002\u00a0<strong>(\u56db)<\/strong>\u00a0H9c2\u7ec6\u80de\u4e2d\u7684MDA\u542b\u91cf\u3002\u00a0<strong>\uff08\u4e94\uff09<\/strong>\u00a0HE \u67d3\u8272\u663e\u793a Dox \u51cf\u5c11\u4e86\u5fc3\u808c\u7ec6\u80de\u7684\u5927\u5c0f\u3002\u5bf9\u7167\u4e0e Dox\uff1a***<em>p<\/em>\u00a0&lt; 0.0005\uff0c**<em>p<\/em>\u00a0&lt; 0.005\uff0c*<em>p<\/em>\u00a0&lt; 0.05\uff0c\u5e73\u5747\u503c\u00b1SD\u3002\u00a0<em>n<\/em>\u00a0= 6\u20139\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p class=\"p p-last\">\u6b63\u5e38\u60c5\u51b5\u4e0b\uff0c\u5fc3\u808c\u4e3b\u8981\u5229\u7528\u7cd6\u7c7b\u548c\u8102\u7c7b\u4f9b\u80fd\uff0c\u7cd6\u7c7b\u548c\u8102\u7c7b\u5206\u522b\u7ea6\u5360\u5fc3\u808c\u80fd\u91cf\u768420%\uff5e30%\u548c60%\uff1b\u6b64\u5916\uff0c\u8461\u8404\u7cd6\u80fd\u66f4\u6709\u6548\u5730\u4ea7\u751f ATP\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B39\" aria-expanded=\"false\" aria-haspopup=\"true\">\u90b5\u548c\u7530\uff0c2015<\/a>\uff09\u3002\u5fc3\u810f\u5982\u4f55\u9002\u5e94\u5316\u7597\u5e72\u9884\u5bf9\u5fc3\u808c\u80fd\u91cf\u4ee3\u8c22\u7684\u91cd\u5851\uff0c\u4ee5\u53ca\u8fd9\u79cd\u6539\u53d8\u662f\u5426\u5f71\u54cd\u5fc3\u810f\u7a33\u6001\u5e76\u5bfc\u81f4 DIC \u7684\u53d1\u5c55\u5c1a\u4e0d\u6e05\u695a\u3002\u901a\u8fc7\u5206\u6790\u5c0f\u9f20\u7684\u4ee3\u8c22\u7ec4\u6570\u636e\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F1\/\" target=\"figure\" rel=\"noopener\">\u56fe1C<\/a>\uff09\uff0c\u6211\u4eec\u53d1\u73b0Dox\u66b4\u9732\u540e\u6c34\u5e73\u5347\u9ad8\u7684\u4ee3\u8c22\u7269\u4e3b\u8981\u6d89\u53ca\u8102\u8d28\u5206\u7c7b\uff0cD-\u8461\u8404\u7cd6-6-\u78f7\u9178\u548cAKG\u7b49\u7cd6\u4ee3\u8c22\u6307\u6807\u6c34\u5e73\u4e0b\u964d\u660e\u663e\u3002\u6b64\u5916\uff0cKEGG \u5bcc\u96c6\u5206\u6790\u663e\u793a\uff0cDox \u66b4\u9732\u540e\u8102\u8d28\u4ee3\u8c22\u9014\u5f84\u53d1\u751f\u663e\u7740\u6539\u53d8\uff08<a class=\"sec\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#s11\">\u8865\u5145\u56feS1<\/a>\uff09\u3002\u5fc3\u808c\u4e2dFAO\u4ee3\u8c22\u7269MDA\u7684\u6c34\u5e73\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F1\/\" target=\"figure\" rel=\"noopener\">\u56fe1D<\/a>\uff09\u5728 Dox \u6cbb\u7597\u540e\u663e\u7740\u5347\u9ad8\u3002\u8fd9\u8868\u660e\uff0cDox \u5e72\u9884\u540e\uff0c\u5fc3\u810f\u7684\u8461\u8404\u7cd6\u4ee3\u8c22\u53d7\u635f\uff0c\u53d6\u800c\u4ee3\u4e4b\u7684\u662f\u8102\u8d28\u71c3\u70e7\u589e\u52a0\uff0c\u800c\u8102\u8d28\u71c3\u70e7\u7684\u80fd\u91cf\u6548\u7387\u76f8\u5bf9\u8f83\u4f4e\u3002\u8fd9\u79cd\u8102\u8d28\u4ee3\u8c22\u4e0d\u8db3\u5bfc\u81f4\u5fc3\u808c\u4e2d\u79ef\u805a\u5927\u91cf\u8102\u8d28\uff0c\u75c5\u7406\u67d3\u8272\u663e\u793aDox\u66b4\u9732\u52a8\u7269\u5fc3\u810f\u4e2d\u51fa\u73b0\u5927\u91cf\u8102\u8d28\u7a7a\u6ce1\uff0c\u5bfc\u81f4\u5fc3\u810f\u8102\u80aa\u53d8\u6027\u3002<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F1\/\" target=\"figure\" rel=\"noopener\">\u56fe1E<\/a>).<\/p>\n<\/div>\n<div id=\"s3-2\" class=\"sec\">\n<h3 id=\"s3-2title\">\u84bd\u73af\u7c7b\u836f\u7269\u4f1a\u589e\u52a0\u5fc3\u808c\u8017\u6c27\u91cf\u5e76\u964d\u4f4e ATP \u751f\u6210\u7387<\/h3>\n<p class=\"p p-first\">\u6709\u8da3\u7684\u662f\uff0c\u8fd9\u79cd\u4ee3\u8c22\u8865\u507f\u589e\u52a0\u4e86\u5fc3\u808c ROS \u6c34\u5e73\uff0c\u5bfc\u81f4\u66f4\u9ad8\u7684\u6c27\u5316\u5e94\u6fc0\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\u56fe2A<\/a>\uff09\u3002 O2K\u80fd\u91cf\u4ee3\u8c22\u5206\u6790\u8868\u660eDox\u589e\u52a0\u5fc3\u808c\u8017\u6c27\u91cf\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\u56fe2B<\/a>\uff09\u5e76\u5bfc\u81f4\u7ebf\u7c92\u4f53\u819c\u8d85\u6781\u5316\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\u56fe2C<\/a>\uff09\uff08\u8fd9\u4e5f\u662f\u7ebf\u7c92\u4f53\u6c27\u5316\u5e94\u6fc0\u6c34\u5e73\u5347\u9ad8\u7684\u6807\u5fd7\uff0c\u5e38\u89c1\u4e8e\u5fc3\u810f\u7f3a\u8840\u518d\u704c\u6ce8\u6a21\u578b\u4e2d\uff09\u3002 JC-1 \u67d3\u8272\u8fd8\u8868\u660e\uff0cDox \u66b4\u9732\u5bfc\u81f4\u4e00\u4e9b\u5b58\u6d3b\u7ec6\u80de\u7684\u819c\u7535\u4f4d\u589e\u52a0\uff08\u7ea2\u8272\u8367\u5149\u5f3a\u5ea6\u589e\u5f3a\uff09\u3002<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\u56fe2D<\/a>\uff09\u3002\u5c3d\u7ba1\u5fc3\u810f\u4e2d\u53d1\u751f\u4e86\u8017\u6c27\u91cf\u589e\u52a0\u548c\u8102\u8d28\u6c27\u5316\u7b49\u4ee3\u507f\u8fc7\u7a0b\uff0c\u4f46\u4e0d\u5e78\u7684\u662f\uff0c\u7531\u4e8e\u8461\u8404\u7cd6\u4ee3\u8c22\u7684\u51cf\u5c11\uff0c\u5fc3\u808c\u4e2d\u7684 ATP \u751f\u6210\u7387\u6025\u5267\u4e0b\u964d\u3002<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\u56fe2E<\/a>\uff09\u3002\u8017\u6c27\u7387\u548cATP\u751f\u6210\u7387\u7684\u6bd4\u8f83\u8868\u660e\uff0cDox\u66b4\u9732\u5bfc\u81f4\u5fc3\u808c\u6d88\u8017\u5927\u91cf\u6c27\u6c14\uff0c\u4f46\u53ea\u4ea7\u751f\u5c11\u91cfATP\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\u56fe2F<\/a>\uff09\uff0c\u5927\u5927\u589e\u52a0\u4e86\u5fc3\u810f\u7684\u8d1f\u62c5\u3002\u8fd9\u79cd\u80fd\u91cf\u8f93\u51fa\u7684\u4e0d\u8db3\u5bfc\u81f4 Dox \u7ec4\u4e2d\u80fd\u91cf\u53d7\u4f53 AMPK \u6c34\u5e73\u663e\u7740\u589e\u52a0\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\u56fe2G<\/a>\uff09\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u5047\u8bbe\u5fc3\u810f\u56e0\u84bd\u73af\u7c7b\u836f\u7269\u5f15\u8d77\u7684\u8461\u8404\u7cd6\u4ee3\u8c22\u53d7\u635f\u800c\u8868\u73b0\u51fa\u9ad8\u8017\u6c27\u7387\u548c\u4f4eATP\u751f\u6210\u7387\uff0c\u8fd9\u79cd\u73b0\u8c61\u4e0d\u80fd\u5b8c\u5168\u6ee1\u8db3\u5fc3\u808c\u7684\u80fd\u91cf\u9700\u6c42\uff0c\u800c\u662f\u5bfc\u81f4\u8fc7\u5ea6\u7684\u6c27\u5316\u5e94\u6fc0\u3002\u56e0\u6b64\u63a8\u6d4b\uff0c\u54cd\u5e94\u80fd\u91cf\u7f3a\u53e3\uff0c\u5fc3\u810f\u4e2d\u7684\u8102\u8d28\u6c27\u5316\u589e\u52a0\uff0c\u66f4\u591a\u7684ROS\u79ef\u7d2f\uff0c\u8fd9\u79cd\u4e0d\u826f\u7684\u53cd\u9988\u9014\u5f84\u53ef\u80fd\u662fDIC\u7684\u91cd\u8981\u9a71\u52a8\u56e0\u7d20\u3002<\/p>\n<div id=\"F2\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm139983201580624\">\n<div class=\"ts_bar small\" title=\"\u70b9\u51fb\u56fe\u7247\u653e\u5927\"><\/div>\n<p><a class=\"inline_block ts_canvas\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/core\/lw\/2.0\/html\/tileshop_pmc\/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&amp;p=PMC3&amp;id=9551275_fphar-13-930835-g002.jpg\" target=\"tileshopwindow\" rel=\"noopener\"><img decoding=\"async\" class=\"tileshop\" title=\"\u70b9\u51fb\u56fe\u7247\u653e\u5927\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/bin\/fphar-13-930835-g002.jpg\" alt=\"An external file that holds a picture, illustration, etc.Object name is fphar-13-930835-g002.jpg\" \/><\/a><\/div>\n<div id=\"lgnd_F2\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F2\/\" target=\"figure\" rel=\"noopener\">\u56fe2<\/a><\/div>\n<div class=\"caption\">\n<p><strong>\uff08A\uff09<\/strong>\u00a0H9c2 \u7ec6\u80de\u4e2d ROS \u67d3\u8272\u7684\u5f3a\u5ea6\u3002\u00a0<strong>(\u4e8c)<\/strong>\u00a0H9c2 \u7ec6\u80de\u7684\u5fc3\u810f\u8017\u6c27\u91cf\u3002\u00a0<strong>\uff08C\uff09<\/strong>\u00a0\u7ebf\u7c92\u4f53\u819c\u7535\u4f4d\u3002\u00a0<strong>(\u56db)<\/strong>\u00a0JC-1 \u67d3\u8272\u548c\u6761\u5f62\u56fe\u3002\u00a0<strong>\uff08\u4e94\uff09<\/strong>\u00a0H9c2 \u7ec6\u80de\u4e2d\u7684 ATP \u542b\u91cf\u3002\u00a0<strong>\uff08F\uff09<\/strong>\u00a0H9c2 \u7ec6\u80de\u4e2d ATP \u4ea7\u91cf\/\u8017\u6c27\u91cf\u4e4b\u6bd4\u3002\u00a0<strong>\uff08G\uff09<\/strong>\u00a0\u6d4b\u5b9aAMPK\u548c\u03b2-\u5fae\u7ba1\u86cb\u767d\u7684\u8868\u8fbe\u6c34\u5e73\u00a0<em>\u4f53\u5916<\/em>\u00a0\u7531\u4e16\u754c\u94f6\u884c\u3002\u5bf9\u7167\u4e0e Dox\uff1a***<em>p<\/em>\u00a0&lt; 0.0005\uff0c**<em>p<\/em>\u00a0&lt; 0.005\uff0c*<em>p<\/em>\u00a0&lt; 0.05\uff0c\u5e73\u5747\u503c\u00b1SD\u3002\u00a0<em>n<\/em>\u00a0= 6\u20139\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"s3-3\" class=\"sec\">\n<h3 id=\"s3-3title\">\u65b0\u578b\u5fc3\u810f\u4fdd\u62a4\u5242\u706f\u76cf\u82b1\u7d20\u4fc3\u8fdb\u5fc3\u810f\u8461\u8404\u7cd6\u4ee3\u8c22\u5e76\u6291\u5236Dox\u8bf1\u5bfc\u7684\u5fc3\u808c\u75c5<\/h3>\n<p class=\"p p-first\">\u53d7\u4e0a\u8ff0\u7ed3\u679c\u7684\u542f\u53d1\uff0c\u6211\u4eec\u4ece\u4ee3\u8c22\u89d2\u5ea6\u7814\u7a76\u4e86\u7528\u4e8e\u6cbb\u7597\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u9ec4\u916e\u7c7b\u706f\u76cf\u82b1\u7d20\u5bf9 DIC \u8fdb\u5c55\u7684\u4fdd\u62a4\u4f5c\u7528\u3002\u5b9e\u9a8c\u65b9\u6848\u5982\u56fe\u6240\u793a\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F3\/\" target=\"figure\" rel=\"noopener\">\u56fe3A<\/a>\uff0c \u548c\u00a0<sup>18<\/sup>\u9996\u6b21\u6ce8\u5c04\u963f\u9709\u7d20 1 \u5468\u540e\uff0c\u5bf9\u5c0f\u9f20\u8fdb\u884c 18F-FDG PET\/CT \u6210\u50cf\u3002\u5982\u56fe\u6240\u793a\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F3\/\" target=\"figure\" rel=\"noopener\">\u56fe3B<\/a>\u706f\u76cf\u82b1\u7d20\u6cbb\u7597\u7ec4\u7684\u5fc3\u810f\u6444\u53d6\u663e\u7740\u9ad8\u4e8e\u5355\u72ec\u7684 Dox \u6cbb\u7597\u7ec4\uff0c\u8868\u660e\u706f\u76cf\u82b1\u7d20\u5e72\u9884\u53ef\u4ee5\u9006\u8f6c Dox \u8bf1\u5bfc\u7684\u5fc3\u810f\u8461\u8404\u7cd6\u4ee3\u8c22\u4e0b\u964d\u5e76\u91cd\u5851\u5fc3\u810f\u80fd\u91cf\u4ee3\u8c22\u3002\u63a5\u4e0b\u6765\u68c0\u67e5\u706f\u76cf\u82b1\u7d20\u6cbb\u7597\u540e\u7684\u5fc3\u529f\u80fd\u548c\u75c5\u7406\u53d8\u5316\uff0c\u5e76\u4ee5\u4e34\u5e8a\u836f\u7269\u53f3\u96f7\u4f50\u751f\uff08Dexra\uff09\u4f5c\u4e3a\u9633\u6027\u5bf9\u7167\u3002\u8d85\u58f0\u5fc3\u52a8\u56fe\u5728\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F3\/\" target=\"figure\" rel=\"noopener\">\u56fe3C<\/a>\u00a0\u7ed3\u679c\u663e\u793a\uff0cDox\u7ec4\u7684LVEF\u548cLVFS\u663e\u7740\u4f4e\u4e8e\u5bf9\u7167\u7ec4\uff0cLVESV\u548cLVD\u663e\u7740\u9ad8\u4e8e\u5bf9\u7167\u7ec4\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0cDox\u6cbb\u7597\u540e\u5c0f\u9f20\u5de6\u5fc3\u5ba4\u6536\u7f29\u529f\u80fd\u4e0b\u964d\uff0c\u672c\u7814\u7a76\u4e2dDox\u5f15\u8d77\u7684\u5fc3\u808c\u635f\u4f24\u4e0e\u6269\u5f20\u578b\u5fc3\u808c\u75c5\u76f8\u4f3c\u3002 Dox \u964d\u4f4e\u4e86\u6536\u7f29\u529f\u80fd\uff0c\u8fd9\u4e0e\u4e4b\u524d\u62a5\u9053\u7684\u7c7b\u4f3c\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B46\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6587\u56fe\u91cc\u5c3c\u7b49\u4eba\uff0c1996<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B41\" aria-expanded=\"false\" 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rel=\"noopener\">\u56fe3D<\/a>\uff09\u3002\u800c\u4e14\uff0c\u4e0d\u540c\u5904\u7406\u540e\u7684\u75c5\u7406\u5fc3\u810f\u7ec4\u7ec7\u67d3\u8272\u663e\u793a\uff0c\u5bf9\u7167\u7ec4\u5c0f\u9f20\u7684\u5fc3\u810f\u7ec4\u7ec7\u7ed3\u6784\u6b63\u5e38\u3002\u4e0e\u5bf9\u7167\u7ec4\u4e0d\u540c\uff0cDox\u7ec4\u5c0f\u9f20\u8868\u73b0\u51fa\u5927\u91cf\u5fc3\u810f\u75c5\u53d8\uff0c\u5305\u62ec\u574f\u6b7b\u3001\u7ec6\u80de\u5185\u6c34\u80bf\u3001\u808c\u539f\u7ea4\u7ef4\u7d0a\u4e71\u548c\u65ad\u88c2\u4ee5\u53ca\u5fc3\u808c\u7ea4\u7ef4\u6ce2\u72b6\u53d8\u6027\u3002\u6709\u8da3\u7684\u662f\uff0c\u706f\u76cf\u82b1\u7d20\u9884\u5904\u7406\u53ef\u4ee5\u9884\u9632\u8fd9\u79cd\u7c7b\u578b\u7684\u635f\u4f24\uff0c\u51cf\u8f7b\u5fc3\u810f\u8102\u8d28\u7684\u8fc7\u5ea6\u79ef\u7d2f\uff0c\u5e76\u6062\u590d\u5fc3\u808c\u7a33\u6001\u3002<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F3\/\" target=\"figure\" 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\u5468\u540e\uff0c\u4f7f\u7528\u5c0f\u9f20\u8fdb\u884c 18F-FDG PET\/CT \u6210\u50cf\uff0c\u5e76\u6d4b\u91cf\u5fc3\u810f\u5438\u6536\u7684 18F-FDG \u6d53\u5ea6\u3002\u00a0<strong>\uff08C\uff09<\/strong>\u00a0\u8d85\u58f0\u5fc3\u52a8\u56fe\u663e\u793a\u706f\u76cf\u82b1\u7d20\u53ef\u9632\u6b62 Dox \u5f15\u8d77\u7684\u5de6\u5fc3\u5ba4\u6269\u5f20\u3002\u4ee3\u8868\u6027 M \u578b\u77ed\u8f74\u8d85\u58f0\u5fc3\u52a8\u56fe\u663e\u793a Dox \u8bf1\u5bfc\u5de6\u5fc3\u5ba4\u6269\u5f20\uff0c\u5e76\u4e14\u706f\u76cf\u82b1\u7d20\u5728 Dox + Brev \u7ec4\u4e2d\u53d1\u6325\u4fdd\u62a4\u4f5c\u7528\u3002\u7528\u706f\u76cf\u82b1\u7d20\u6cbb\u7597\u7684\u5c0f\u9f20\u8212\u5f20\u671f\u7684 EF \u548c FS \u663e\u7740\u4f4e\u4e8e\u7528 Dox \u6cbb\u7597\u7684\u5c0f\u9f20\uff0c\u800c HR \u663e\u7740\u8f83\u9ad8\u3002\u00a0<strong>(\u56db)<\/strong>\u00a0\u706f\u76cf\u82b1\u7d20\u964d\u4f4e cTnI \u7684\u6d53\u5ea6\u3002\u00a0<strong>\uff08\u4e94\uff09<\/strong>\u00a0Masson\u67d3\u8272\u663e\u793a\u706f\u76cf\u82b1\u7d20\u53ef\u964d\u4f4eDox\u8bf1\u5bfc\u7684\u5fc3\u810f\u7ea4\u7ef4\u5316\u7a0b\u5ea6\u3002\u00a0<strong>\uff08F\uff09<\/strong>\u00a0HE \u67d3\u8272\u663e\u793a\u706f\u76cf\u82b1\u7d20\u53ef\u4ee5\u9632\u6b62\u5fc3\u810f\u4e2d Dox \u5f15\u8d77\u7684\u5fc3\u808c\u7ec6\u80de\u5927\u5c0f\u51cf\u5c11\u3002\u5bf9\u7167\u5bf9\u6bd4 Dox\u30014 mg\/kg\u30018 mg\/kg \u6216 16 mg\/kg Brev \u5bf9\u6bd4 Dox \u4ee5\u53ca Dexra \u5bf9\u6bd4 Dox\uff1a***<em>p<\/em>\u00a0&lt; 0.0005\uff0c**<em>p<\/em>\u00a0&lt; 0.005\uff0c*<em>p<\/em>\u00a0&lt; 0.05\uff0c\u5e73\u5747\u503c\u00b1SD\u3002\u00a0<em>n<\/em>\u00a0= 6\u20139\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"s3-4\" class=\"sec\">\n<h3 id=\"s3-4title\">\u706f\u76cf\u82b1\u7d20\u901a\u8fc7\u8c03\u8282\u5916\u5468\u8840\u6e05\u6c34\u5e73\u548c\u5fc3\u808c AKT \u8868\u8fbe\u6765\u91cd\u5851\u5fc3\u810f\u8461\u8404\u7cd6\u548c\u8102\u8d28\u4ee3\u8c22<\/h3>\n<p class=\"p p-first\">\u63a5\u4e0b\u6765\uff0c\u6211\u4eec\u7814\u7a76\u4e86\u706f\u76cf\u82b1\u7d20\u5982\u4f55\u8c03\u8282\u7cd6\u548c\u8102\u80aa\u4ee3\u8c22\u7684\u5e73\u8861\u3002\u5982\u56fe\u6240\u793a\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F4\/\" target=\"figure\" rel=\"noopener\">\u56fe4E<\/a>\u4e0eDox\u5904\u7406\u5c0f\u9f20\u76f8\u6bd4\uff0c\u706f\u76cf\u82b1\u7d20\u6cbb\u7597\u5c0f\u9f20\u5916\u5468\u8840\u6e05\u4e2d\u8840\u6e05\u7d20\u6c34\u5e73\u663e\u7740\u5347\u9ad8\uff0c\u4e14\u964d\u4f4e\u7a0b\u5ea6\u4e0e\u706f\u76cf\u82b1\u7d20\u5242\u91cf\u5448\u7ebf\u6027\u5173\u7cfb\uff0c\u964d\u4f4e\u5e45\u5ea6\u8d85\u8fc795%\u5728\u9ad8\u5242\u91cf\u7ec4\u4e2d\u89c2\u5bdf\u5230\u3002\u8840\u6e05\u7d20 (5-HT) \u662f\u4e00\u79cd\u5355\u80fa\uff0c\u5728\u795e\u7ecf\u5143\u548c\u975e\u795e\u7ecf\u5143\u7cfb\u7edf\u4e2d\u5177\u6709\u591a\u79cd\u529f\u80fd\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B31\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5965\u5361\u8482\u7b49\u4eba\uff0c2019<\/a>\uff09\u3002\u5728\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u4e2d\uff0c5-HT \u5145\u5f53\u8c03\u8282\u60c5\u7eea\u548c\u8fdb\u98df\u884c\u4e3a\u7684\u795e\u7ecf\u9012\u8d28\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B2\" aria-expanded=\"false\" aria-haspopup=\"true\">\u4f2f\u6770\u7b49\u4eba\uff0c2009<\/a>\uff09\u3002\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0c\u5916\u54685-HT\u901a\u8fc7\u6291\u5236\u68d5\u8272\u8102\u80aa\u7ec4\u7ec7\u7684\u9002\u5e94\u6027\u751f\u70ed\u4f5c\u7528\uff0c\u5728\u5916\u5468\u7ec4\u7ec7\u7684\u4ee3\u8c22\u8c03\u8282\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002\u5728\u996e\u98df\u8bf1\u5bfc\u7684\u80a5\u80d6\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u6291\u5236 5-HT \u5408\u6210\u53ef\u51cf\u5c11\u4f53\u91cd\u589e\u52a0\u5e76\u6539\u5584\u4ee3\u8c22\u529f\u80fd\u969c\u788d\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B56\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6cfd\u59c6\u5fb7\u683c\u65af\u7b49\u4eba\uff0c2016<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B51\" aria-expanded=\"false\" aria-haspopup=\"true\">\u590f\u7b49\u4eba\uff0c2021<\/a>\uff09\u3002\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\u8fd8\u63ed\u793a\u4e86\u8840\u6e05\u7d20\u7cfb\u7edf\u4e0e\u80a5\u80d6\u4e4b\u95f4\u7684\u9057\u4f20\u8054\u7cfb\u3002\u8840\u6e05\u7d20\u5bf9\u8461\u8404\u7cd6\u4ee3\u8c22\u6709\u4e24\u79cd\u4e0d\u540c\u7684\u4f5c\u7528\uff1a\u5b83\u76f4\u63a5\u8bf1\u5bfc\u80f0\u817aB\u7ec6\u80de\u5206\u6ccc\u80f0\u5c9b\u7d20\uff0c\u964d\u4f4e\u8840\u7cd6\u6c34\u5e73\uff1b\u5b83\u4f1a\u6291\u5236\u809d\u810f\u548c\u9aa8\u9abc\u808c\u4ee5\u5916\u7684\u7ec4\u7ec7\u4ece\u8840\u6db2\u4e2d\u6444\u53d6\u8461\u8404\u7cd6\uff0c\u4ece\u800c\u63d0\u9ad8\u8840\u7cd6\u6c34\u5e73\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B47\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6e21\u8fb9\u7b49\u4eba\uff0c2011<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B4\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5361\u6885\u6069\u7b49\u4eba\uff0c2019<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B53\" aria-expanded=\"false\" aria-haspopup=\"true\">\u4e9a\u5e03\u7279\u7b49\u4eba\uff0c2019<\/a>\uff09\u3002\u7814\u7a76\u8868\u660e\uff0c\u8840\u6e05\u7d20\u6cbb\u7597\u53ef\u5bfc\u81f4\u8840\u7cd6\u6c34\u5e73\u7a81\u7136\u5927\u5e45\u5347\u9ad8\uff0c\u4f46\u8840\u6e05\u7d20\u5982\u4f55\u6291\u5236\u7ec4\u7ec7\u4ece\u8840\u6db2\u4e2d\u6444\u53d6\u8461\u8404\u7cd6\u4ecd\u4e0d\u6e05\u695a\u3002\u6211\u4eec\u7684\u5b9e\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u706f\u76cf\u82b1\u7d20\u6cbb\u7597\u540e\uff0c\u5916\u5468\u8840\u6e05\u7d20\u6c34\u5e73\u6025\u5267\u4e0b\u964d\uff0c\u5bf9\u5e94\u4e8e\u5fc3\u810f\u8461\u8404\u7cd6\u6444\u5165\u91cf\u7684\u589e\u52a0\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F4\/\" target=\"figure\" rel=\"noopener\">\u56fe4E<\/a>\uff09\uff0c\u800c\u809d\u810f\u8461\u8404\u7cd6\u6444\u5165\u91cf\u6ca1\u6709\u663e\u7740\u53d8\u5316\uff08<a class=\"sec\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#s11\">\u8865\u5145\u56feS2<\/a>\uff09\u548c\u7a7a\u8179\u8840\u7cd6\uff08FBG\uff09\u6c34\u5e73\u964d\u4f4e\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F4\/\" target=\"figure\" rel=\"noopener\">\u56fe4A<\/a>\uff09\u3002\u5728\u706f\u76cf\u82b1\u7d20\u7ec4\u4e2d\uff0c\u989d\u5916\u8865\u5145 5-HT \u4f1a\u589e\u52a0\u5c0f\u9f20\u7684\u8840\u6e05\u7d20\u6c34\u5e73\u5e76\u51cf\u5c11\u5fc3\u810f\u8461\u8404\u7cd6\u6444\u53d6\u3002<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F4\/\" target=\"figure\" 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\u7f3a\u5931\u4f1a\u964d\u4f4e\u5fc3\u808c\u7ec6\u80de\u4ee3\u8c22\u8461\u8404\u7cd6\u7684\u80fd\u529b\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u706f\u76cf\u82b1\u7d20\u901a\u8fc7\u663e\u7740\u964d\u4f4e\u8840\u6e05\u7d20\u6c34\u5e73\uff0c\u89e3\u9664\u8840\u6e05\u7d20\u5bf9\u7ec4\u7ec7\u8461\u8404\u7cd6\u6444\u53d6\u7684\u6291\u5236\u4f5c\u7528\uff0c\u4fdd\u8bc1\u75c5\u7406\u72b6\u6001\u4e0b\u8840\u6db2\u4e2d\u8461\u8404\u7cd6\u7684\u5438\u6536\uff0c\u63ed\u793a\u4e86\u673a\u4f53\u53ef\u80fd\u53c2\u4e0e\u5fc3\u810f\u4ee3\u8c22\u8c03\u8282\u7684\u53ef\u80fd\u6027\u3002\u901a\u8fc7\u795e\u7ecf\u9012\u8d28\u8fdb\u884c\u91cd\u5851\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u706f\u76cf\u82b1\u7d20\u4f5c\u4e3a\u6211\u56fd\u5e38\u7528\u7684\u5fc3\u8840\u7ba1\u836f\u7269\uff0c\u53ef\u964d\u4f4e\u5916\u5468\u8840\u6e05\u7d20\u6c34\u5e7390%\u4ee5\u4e0a\uff0c\u5728\u6cbb\u7597\u5fc3\u808c\u7cd6\u4ee3\u8c22\u6240\u81f4\u7684\u5fc3\u808c\u80a5\u539a\u548c\u5fc3\u529b\u8870\u7aed\u65b9\u9762\u6bd4\u7ecf\u5178\u7684\u8840\u6e05\u7d20\u518d\u6444\u53d6\u6291\u5236\u5242\u6c1f\u897f\u6c40\u5177\u6709\u66f4\u5f3a\u52b2\u7684\u6548\u679c\u3002\u75be\u75c5\u548c\u7cd6\u5c3f\u75c5\uff0c\u4ee3\u8868\u4e86\u6cbb\u7597\u963f\u9709\u7d20\u5f15\u8d77\u7684\u5fc3\u810f\u6bd2\u6027\u7684\u4e00\u79cd\u65b0\u7684\u5b89\u5168\u836f\u7269\u3002\u6d41\u884c\u75c5\u5b66\u7814\u7a76\u8fd8\u8868\u660e\uff0c\u7cd6\u5c3f\u75c5\u4f1a\u589e\u52a0\u963f\u9709\u7d20\u5f15\u8d77\u7684\u5fc3\u810f\u6bd2\u6027\u7684\u98ce\u9669\uff1b\u56e0\u6b64\uff0c\u8fd9\u9879\u7814\u7a76\u4e3a\u7cd6\u5c3f\u75c5\u548c\u764c\u75c7\u60a3\u8005\u63d0\u4f9b\u4e86\u4e00\u79cd\u6f5c\u5728\u7684\u6cbb\u7597\u7b56\u7565\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B5\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5f20\u7b49\u4eba\uff0c2021<\/a>).<\/p>\n<div id=\"F4\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm139983196531152\">\n<div class=\"ts_bar small\" title=\"\u70b9\u51fb\u56fe\u7247\u653e\u5927\"><\/div>\n<p><a class=\"inline_block ts_canvas\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/core\/lw\/2.0\/html\/tileshop_pmc\/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&amp;p=PMC3&amp;id=9551275_fphar-13-930835-g004.jpg\" target=\"tileshopwindow\" rel=\"noopener\"><img decoding=\"async\" class=\"tileshop\" title=\"\u70b9\u51fb\u56fe\u7247\u653e\u5927\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/bin\/fphar-13-930835-g004.jpg\" alt=\"An external file that holds a picture, illustration, etc.Object name is fphar-13-930835-g004.jpg\" \/><\/a><\/div>\n<div id=\"lgnd_F4\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F4\/\" target=\"figure\" rel=\"noopener\">\u56fe4<\/a><\/div>\n<div class=\"caption\">\n<p><strong>\uff08A\uff09<\/strong>\u00a0\u5c0f\u9f20\u7684\u7a7a\u8179\u8840\u7cd6\u6c34\u5e73\u3002\u00a0<strong>(\u4e8c)<\/strong>\u00a0\u6d53\u5ea6\u00a0<sup>18<\/sup>\u8865\u5145 5-HT \u540e\uff0cF-FDG \u88ab\u5fc3\u810f\u5438\u6536\u3002\u00a0<strong>\uff08C\uff09<\/strong>\u00a0\u8865\u5145 5-HT \u540e\u8f6c\u5f55\u7ec4\u5206\u6790\u7684\u70ed\u56fe\u3002\u00a0<strong>(\u56db)<\/strong>\u00a0\u68c0\u6d4bPI3K\u3001Akt\u3001GAPDH\u7684\u8868\u8fbe\u6c34\u5e73\u00a0<em>\u4f53\u5916<\/em>\u00a0\u7531\u4e16\u754c\u94f6\u884c\u3002\u00a0<strong>\uff08\u4e94\uff09<\/strong>\u00a0\u5c0f\u9f20\u5916\u5468\u8840\u6e05\u4e2d\u7684\u8840\u6e05\u7d20\u6c34\u5e73\u3002\u00a0<strong>\uff08F\uff09<\/strong>\u00a0\u5c0f\u9f20\u4f53\u5185 D-\u8461\u8404\u7cd6 6-\u78f7\u9178\u6c34\u5e73\u3002\u00a0<strong>\uff08G\uff09<\/strong>\u00a0\u5c0f\u9f20\u4f53\u5185\u03b1-\u916e\u620a\u4e8c\u9178\u7684\u6c34\u5e73\u3002\u5bf9\u7167\u4e0e Dox\u30014 mg\/kg\u30018 mg\/kg \u6216 16 mg\/kg Brev \u4e0e Dox \u4ee5\u53ca Brev+5-HT \u4e0e Brev\uff1a***<em>p<\/em>\u00a0&lt; 0.0005\uff0c**<em>p<\/em>\u00a0&lt; 0.005\uff0c*<em>p<\/em>\u00a0&lt; 0.05\uff0c\u5e73\u5747\u503c\u00b1SD\u3002\u00a0<em>n<\/em>\u00a0= 6\u20139\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p class=\"p\">\u57fa\u4e8e\u8fd9\u4e9b\u53d1\u73b0\uff0c\u6211\u4eec\u7814\u7a76\u4e86\u706f\u76cf\u82b1\u7d20\u5982\u4f55\u8c03\u8282\u8840\u7cd6\u3002\u968f\u5fc3\u6240\u7528\u3002\u7ed3\u679c\u663e\u793a\uff0c\u706f\u76cf\u82b1\u7d20\u5e72\u9884\u540e\uff0cDox\u66b4\u9732\u5c0f\u9f20\u4f53\u5185PI3K\u86cb\u767d\u8868\u8fbe\u663e\u7740\u964d\u4f4e\uff0c\u5fc3\u810f\u7ec4\u7ec7\u4e2dPI3K\u86cb\u767d\u8868\u8fbe\u6c34\u5e73\u663e\u7740\u5347\u9ad8\u3002\u6709\u8da3\u7684\u662f\uff0c\u5728\u5bf9\u7167\u7ec4\u548c Dox \u66b4\u9732\u7ec4\u4e2d\uff0cAKT \u8868\u8fbe\u5747\u7ef4\u6301\u5728\u8f83\u4f4e\u6c34\u5e73\uff0c\u5e76\u4e14\u5728\u706f\u76cf\u82b1\u7d20\u6cbb\u7597\u540e\u89c2\u5bdf\u5230 AKT \u8868\u8fbe\u663e\u7740\u589e\u52a0\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F4\/\" target=\"figure\" rel=\"noopener\">\u56fe4D<\/a>\uff09\u3002\u5148\u524d\u7684\u7814\u7a76\u8868\u660e AKT \u523a\u6fc0\u7ec6\u80de\u4e2d\u7684\u8461\u8404\u7cd6\u4ee3\u8c22\uff0c\u5c06\u8461\u8404\u7cd6\u8f6c\u5316\u4e3a D-\u8461\u8404\u7cd6 6-\u78f7\u9178\u00a0<em>\u901a\u8fc7<\/em>\u00a0\u5df1\u7cd6\u6fc0\u9176\u7528\u4e8e\u7cd6\u9175\u89e3\u6216\u805a\u5408\u6210\u7cd6\u539f\u3002\u6211\u4eec\u7684\u7ed3\u679c\u8868\u660e\uff0c\u706f\u76cf\u82b1\u7d20\u4fc3\u8fdb\u5fc3\u808cAKT\u8868\u8fbe\u540e\uff0c\u7cd6\u4ee3\u8c22\u76f8\u5173\u7684D-\u8461\u8404\u7cd66-\u78f7\u9178\u548c\u03b1-\u916e\u620a\u4e8c\u9178\u6c34\u5e73\u663e\u7740\u5347\u9ad8\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F4\/\" target=\"figure\" rel=\"noopener\">\u56fe4F<\/a>\uff0cG)\uff0c\u8868\u660e\u706f\u76cf\u82b1\u7d20\u901a\u8fc7AKT\u589e\u5f3a\u5fc3\u808c\u5229\u7528\u8461\u8404\u7cd6\u4f5c\u4e3a\u80fd\u91cf\u6765\u6e90\u7684\u80fd\u529b\uff0c\u4fc3\u8fdb\u8461\u8404\u7cd6\u5206\u89e3\u4ee3\u8c22\u3002\u65e2\u5f80\u7814\u7a76\u62a5\u9053\uff0cPI3K-Akt\u8868\u8fbe\u589e\u52a0\u53ef\u4ee5\u4fc3\u8fdb\u5916\u5468\u7ec4\u7ec7\u7cd6\u5229\u7528\uff0c\u964d\u4f4e\u80f0\u5c9b\u7d20\u62b5\u6297\uff0c\u589e\u5f3a\u5fc3\u810f\u80fd\u91cf\u4f9b\u5e94\uff0c\u9884\u9632\u5fc3\u529f\u80fd\u4e0d\u5168\uff0c\u800cPI3K-Akt\u901a\u8def\u7684\u6291\u5236\u5219\u5f71\u54cd\u5fc3\u808c\u7ec6\u80de\u7684\u751f\u7406\u6d3b\u52a8\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B57\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6731\u7b49\uff0c2013<\/a>\uff09\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\u706f\u76cf\u82b1\u7d20\u901a\u8fc7\u8c03\u8282 PI3K-Akt \u901a\u8def\u7684\u6fc0\u6d3b\u6765\u589e\u5f3a\u5bf9 Dox \u8bf1\u5bfc\u7684\u5fc3\u808c\u635f\u4f24\u7684\u62b5\u6297\u529b\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\u706f\u76cf\u82b1\u7d20\u901a\u8fc7\u6291\u5236\u8840\u6e05\u7d20\u8c03\u8282\u8840\u7cd6\u6c34\u5e73\uff0c\u963b\u65ad\u5fc3\u808c\u8461\u8404\u7cd6\u5229\u7528\u7684\u9650\u5236\uff0c\u5e76\u901a\u8fc7\u6fc0\u6d3bPI3K-Akt\u9014\u5f84\u4fc3\u8fdb\u5fc3\u808c\u8461\u8404\u7cd6\u4ee3\u8c22\u3002\u56e0\u6b64\uff0c5-\u7f9f\u8272\u80fa\u53ef\u80fd\u662f\u8c03\u8282\u5fc3\u810f\u7cd6\u8102\u4ee3\u8c22\u7684\u91cd\u8981\u9776\u70b9\u3002\u7136\u540e\uff0c\u6211\u4eec\u5206\u6790\u4e86\u5fc3\u808c\u7cd6\u8102\u4ee3\u8c22\u91cd\u5851\u540e\u5fc3\u810f\u529f\u80fd\u548c\u7a33\u6001\u7684\u53d8\u5316\u3002\u4e0eDox\u6a21\u578b\u7ec4\u76f8\u6bd4\uff0c\u706f\u76cf\u82b1\u7d20\u6cbb\u7597\u7ec4\u5fc3\u808cATP\u751f\u6210\u663e\u7740\u589e\u52a0\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F5\/\" target=\"figure\" rel=\"noopener\">\u56fe5A<\/a>\uff09\uff0c\u800cROS\u548cFAO\u4ee3\u8c22\u7269MDA\u7684\u6c34\u5e73\u663e\u7740\u964d\u4f4e\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F5\/\" target=\"figure\" rel=\"noopener\">\u56fe5B\u3001E<\/a>\uff09\u3002 O2K\u80fd\u91cf\u4ee3\u8c22\u5206\u6790\u8868\u660e\uff0c\u706f\u76cf\u82b1\u7d20\u53ef\u6291\u5236Dox\u66b4\u9732\u5f15\u8d77\u7684\u5fc3\u810f\u8017\u6c27\u91cf\u7684\u6025\u5267\u589e\u52a0\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F5\/\" target=\"figure\" rel=\"noopener\">\u56fe5C<\/a>\uff09\uff0c\u663e\u7740\u964d\u4f4e\u4e86 ATP \u4ea7\u91cf\/\u8017\u6c27\u91cf\u6bd4\u7387\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F5\/\" target=\"figure\" rel=\"noopener\">\u56fe5D<\/a>\uff09\uff0c\u5e76\u5c06\u7ebf\u7c92\u4f53\u819c\u7535\u4f4d\u6807\u51c6\u5316\uff08<a class=\"sec\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#s11\">\u8865\u5145\u56feS4<\/a>\uff09\u3002\u8fd9\u8868\u660e\u706f\u76cf\u82b1\u7d20\u6cbb\u7597\u589e\u52a0\u4e86\u5fc3\u808c\u4f7f\u7528\u9ad8\u80fd\u6548\u7387\u8461\u8404\u7cd6\u4f5c\u4e3a\u80fd\u6e90\u7684\u80fd\u529b\uff1b\u63d0\u9ad8ATP\u751f\u4ea7\u6548\u7387\uff1b\u5e76\u51cf\u5c11\u5fc3\u810f\u8d1f\u8377\u3001\u6c27\u5316\u5e94\u6fc0\u548c\u5fc3\u808c\u8017\u6c27\u91cf\u3002\u7efc\u4e0a\u6240\u8ff0\uff0c\u706f\u76cf\u82b1\u7d20\u53ef\u901a\u8fc7\u8c03\u8282\u8840\u6e05\u7d20-\u8840\u7cd6-\u5fc3\u808cAKT\u73af\u8def\uff0c\u91cd\u5851\u5fc3\u808c\u80fd\u91cf\u4ee3\u8c22\uff0c\u589e\u52a0\u8461\u8404\u7cd6\u5229\u7528\u7387\uff0c\u964d\u4f4eFAO\uff0c\u6709\u6548\u6253\u7834Dox\u66b4\u9732\u5f15\u8d77\u7684\u5fc3\u810f\u9ad8\u8017\u6c27\u7387\u548c\u8102\u8d28\u71c3\u70e7\u4e0d\u5145\u5206\u7684\u6076\u6027\u5faa\u73af\u3002 \uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F5\/\" target=\"figure\" rel=\"noopener\">\u56fe5F<\/a>\uff09\uff0c\u963b\u6b62DIC\u7684\u8fdb\u4e00\u6b65\u53d1\u5c55\u3002<\/p>\n<div id=\"F5\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm139983197130224\">\n<div class=\"ts_bar small\" title=\"\u70b9\u51fb\u56fe\u7247\u653e\u5927\"><\/div>\n<p><a class=\"inline_block ts_canvas\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/core\/lw\/2.0\/html\/tileshop_pmc\/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&amp;p=PMC3&amp;id=9551275_fphar-13-930835-g005.jpg\" target=\"tileshopwindow\" rel=\"noopener\"><img decoding=\"async\" class=\"tileshop\" title=\"\u70b9\u51fb\u56fe\u7247\u653e\u5927\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/bin\/fphar-13-930835-g005.jpg\" alt=\"An external file that holds a picture, illustration, etc.Object name is fphar-13-930835-g005.jpg\" \/><\/a><\/div>\n<div id=\"lgnd_F5\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F5\/\" target=\"figure\" rel=\"noopener\">\u56fe5<\/a><\/div>\n<div class=\"caption\">\n<p><strong>\uff08A\uff09<\/strong>\u00a0H9c2 \u7ec6\u80de\u4e2d\u7684 ATP \u542b\u91cf\u3002\u00a0<strong>(\u4e8c)<\/strong>\u00a0H9c2\u7ec6\u80de\u4e2d\u7684MDA\u542b\u91cf\u3002\u00a0<strong>\uff08C\uff09<\/strong>\u00a0H9c2 \u7ec6\u80de\u7684\u5fc3\u810f\u8017\u6c27\u91cf\u3002\u00a0<strong>(\u56db)<\/strong>\u00a0H9c2 \u7ec6\u80de\u4e2d ATP \u4ea7\u91cf\/\u8017\u6c27\u91cf\u4e4b\u6bd4\u3002\u00a0<strong>\uff08\u4e94\uff09<\/strong>\u00a0H9c2 \u7ec6\u80de\u4e2d ROS \u67d3\u8272\u7684\u5f3a\u5ea6\u3002\u00a0<strong>\uff08F\uff09<\/strong>\u00a0\u539f\u7406\u56fe\uff0c\u793a\u610f\u56fe\u3002 Control \u4e0e Dox\u3001Brev \u4e0e Dox \u4ee5\u53ca Dexra \u4e0e Dox\uff1a***<em>p<\/em>\u00a0&lt; 0.0005\uff0c**<em>p<\/em>\u00a0&lt; 0.005\uff0c*<em>p<\/em>\u00a0&lt; 0.05\uff0c\u5e73\u5747\u503c\u00b1SD\u3002\u00a0<em>n<\/em>\u00a0= 6\u20139\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"s3-5\" class=\"sec\">\n<h3 id=\"s3-5title\">\u706f\u76cf\u82b1\u7d20\u901a\u8fc7 PINK1\/Parkin \u4fe1\u53f7\u901a\u8def\u6e05\u9664 Dox \u6cbb\u7597\u540e\u7684\u7ebf\u7c92\u4f53\u635f\u4f24\u5e76\u6062\u590d\u5fc3\u808c\u7a33\u6001<\/h3>\n<p class=\"p p-first\">\u5c3d\u7ba1\u5728\u8fc7\u53bb\u51e0\u5341\u5e74\u4e2d\u5173\u4e8e DIC \u673a\u5236\u7684\u5047\u8bbe\u6709\u6240\u4e0d\u540c\uff0c\u4f46 DIC \u7684\u5173\u952e\u7279\u5f81\u662f\u6c27\u5316\u8fd8\u539f\u5931\u8861\u548c\u7ebf\u7c92\u4f53\u529f\u80fd\u53d7\u635f\u3002\u8be5\u7ed3\u679c\u963b\u6b62\u4e86\u4e4b\u524d\u4ece\u5fc3\u810f\u80fd\u91cf\u6bd4\u548c\u80fd\u91cf\u8f93\u51fa\u6548\u7387\u89d2\u5ea6\u6539\u8fdbDIC\u53d1\u5c55\u7684\u5047\u8bbe\uff0c\u4f46\u63d0\u51fa\u4e86\u4e00\u4e2a\u5173\u952e\u95ee\u9898\uff0c\u5373\u706f\u76cf\u82b1\u7d20\u5982\u4f55\u901a\u8fc7\u4f18\u5316\u7ebf\u7c92\u4f53\u540e\u5fc3\u810f\u5185\u7684\u4ee3\u8c22\u7f51\u7edc\u6765\u5b9e\u73b0\u9ad8\u6548\u7684\u80fd\u91cf\u4ea7\u751f\u548c\u5fc3\u810f\u5fae\u73af\u5883\u7a33\u6001\u3002\u53d7\u4f24\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u65e8\u5728\u56de\u7b54\u8fd9\u4e2a\u95ee\u9898\u3002 Pten\u8bf1\u5bfc\u7684\u63a8\u5b9a\u6fc0\u91761 PINK1\/Parkin\u4fe1\u53f7\u901a\u8def\u662f\u7ebf\u7c92\u4f53\u81ea\u566c\u4ecb\u5bfc\u7684\u4e3b\u8981\u901a\u8def\u4e4b\u4e00\uff0c\u5728\u7ef4\u6301\u5fc3\u808c\u7ec6\u80de\u7684\u80fd\u91cf\u4ee3\u8c22\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B7\" aria-expanded=\"false\" aria-haspopup=\"true\">Dewanjee \u7b49\u4eba\uff0c2021<\/a>\uff09\u3002\u5f53\u5fc3\u808c\u7ec6\u80de\u5185\u7684\u7ebf\u7c92\u4f53\u53d7\u635f\u65f6\uff0cPINK1\u4f5c\u4e3a\u7ebf\u7c92\u4f53\u8d28\u63a7\u7cfb\u7edf\u7684\u201c\u54e8\u5175\u201d\uff0c\u4f1a\u5728\u7ebf\u7c92\u4f53\u5916\u819c\u805a\u96c6\uff0c\u805a\u96c6\u5e76\u78f7\u9178\u5316Parkin\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B33\" aria-expanded=\"false\" aria-haspopup=\"true\">\u666e\u5c14\u548c\u9ea6\u514b\u52b3\u5fb7\uff0c2021<\/a>\uff09\u3002\u6fc0\u6d3b\u7684 Parkin \u6cdb\u7d20\u5316\u53d7\u635f\u7684\u7ebf\u7c92\u4f53\uff0c\u7136\u540e\u4e0e\u6eb6\u9176\u4f53\u878d\u5408\u4ee5\u5b8c\u6210\u964d\u89e3\u3002 PINK1\/Parkin \u4fe1\u53f7\u901a\u8def\u4ecb\u5bfc\u7684\u7ebf\u7c92\u4f53\u81ea\u566c\u589e\u5f3a\u53ef\u4ee5\u7ef4\u6301\u5fc3\u808c\u7ec6\u80de\u4e2d\u7684\u7ebf\u7c92\u4f53\u7a33\u6001\u5e76\u51cf\u7f13\u5fc3\u810f\u75c5\u7684\u8fdb\u5c55\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B8\" aria-expanded=\"false\" aria-haspopup=\"true\">\u591a\u6069\uff0c2016<\/a>).<\/p>\n<p>\u56e0\u6b64\uff0c\u6211\u4eec\u63a8\u6d4b\u706f\u76cf\u82b1\u7d20\u901a\u8fc7PINK1\/Parkin\u901a\u8def\u589e\u5f3a\u7ebf\u7c92\u4f53\u81ea\u566c\uff0c\u7ef4\u6301\u5fc3\u808c\u7ec6\u80de\u7ebf\u7c92\u4f53\u7a33\u6001\u3002 WB\u663e\u793a\uff0c\u4e0eDox\u7ec4\u76f8\u6bd4\uff0c\u706f\u76cf\u82b1\u7d20\u6cbb\u7597\u7ec4PINK1\/Parkin\u603b\u86cb\u767d\u8868\u8fbe\u6c34\u5e73\u663e\u7740\u5347\u9ad8\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\u56fe6A<\/a>\uff09\uff0c\u76f8\u5e94\u7684\u78f7\u9178\u5316\u6c34\u5e73\u4e5f\u663e\u7740\u5347\u9ad8\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\u56fe6B<\/a>\uff09\u3002 Dox\u6cbb\u7597\u7ec4\u4e2dPINK1\/Parkin\u86cb\u767d\u8868\u8fbe\u5448\u4e0b\u964d\u8d8b\u52bf\uff0c\u86cb\u767d\u78f7\u9178\u5316\u663e\u7740\u964d\u4f4e\uff0c\u800c\u7ebf\u7c92\u4f53\u819c\u86cb\u767dTom20\u6c34\u5e73\u5347\u9ad8\uff0c\u63d0\u793aDox\u867d\u7136\u8bf1\u5bfc\u7ebf\u7c92\u4f53\u635f\u4f24\uff0c\u4f46\u6291\u5236\u4e86\u53d7\u635f\u7ec6\u80de\u7684\u53ca\u65f6\u6e05\u9664\u3002\u7ebf\u7c92\u4f53\u3002\u5728 Dox \u7ec4\u4e2d\u89c2\u5bdf\u5230\u5927\u91cf\u65ad\u88c2\u548c\u53d7\u635f\u7684\u7ebf\u7c92\u4f53\uff08\u7ea2\u8272\u7bad\u5934\uff0c\u00a0<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\u56fe6D<\/a>\uff09\uff0c\u800c\u5728 Brev \u7ec4\u4e2d\u89c2\u5bdf\u5230\u5927\u91cf\u6eb6\u9176\u4f53\u5305\u88f9\u7684\u7ebf\u7c92\u4f53\u81ea\u566c\uff08\u84dd\u8272\u7bad\u5934\uff09\u3002\u540c\u65f6\u5e94\u7528Dox\u548cBrev\u65f6\uff0c\u7ebf\u7c92\u4f53\u5d74\u660e\u663e\uff0c\u7ebf\u7c92\u4f53\u5f62\u6001\u6b63\u5e38\uff0c\u819c\u7ed3\u6784\u5b8c\u6574\u3002\u7528 MitoTracker \u67d3\u8272\u540e\uff0c\u53d1\u73b0 Dox \u7ec4\u7684\u8367\u5149\u5f3a\u5ea6\u6700\u9ad8\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\u56fe6C<\/a>\uff09\uff0c\u8868\u660e Dox \u7ec4\u7684\u7ebf\u7c92\u4f53\u660e\u663e\u591a\u4e8e\u5bf9\u7167\u7ec4\u548c Brev \u7ec4\u3002\u6b64\u5916\uff0cBrev \u6cbb\u7597\u540e\u6297\u6c27\u5316\u86cb\u767d NADH \u548c SOD \u7684\u6c34\u5e73\u663e\u7740\u589e\u52a0\uff08<a class=\"sec\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#s11\">\u8865\u5145\u56feS5<\/a>\uff09\u3002\u4e0e Dox \u7ec4\u76f8\u6bd4\uff0cBrev \u6cbb\u7597\u7ec4\u80fd\u91cf\u53d7\u4f53 AMPK \u7684\u78f7\u9178\u5316\u663e\u7740\u964d\u4f4e\uff0c\u540c\u65f6\u7ec6\u80de\u751f\u957f\u63a7\u5236\u4e2d\u5fc3\u88ab\u6fc0\u6d3b\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\u56fe6E<\/a>\uff09\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0cDox\u66b4\u9732\u4f1a\u5bfc\u81f4\u5fc3\u808c\u635f\u4f24\u3001\u7ebf\u7c92\u4f53\u79ef\u7d2f\u548c\u4f53\u5185\u5e73\u8861\u5931\u8861\uff0c\u8fd9\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u89e3\u91ca\u4e86\u4e3a\u4ec0\u4e48Dox\u7ed9\u836f\u540e\u5fc3\u810f\u80fd\u91cf\u8f93\u51fa\u6548\u7387\u964d\u4f4e\u3001\u6c27\u5316\u5e94\u6fc0\u589e\u52a0\u3002\u706f\u76cf\u82b1\u7d20\u53ef\u4fc3\u8fdb\u7ebf\u7c92\u4f53\u81ea\u566c\uff0c\u6e05\u9664\u53d7\u635f\u7ebf\u7c92\u4f53\uff0c\u6062\u590d\u5fc3\u808c\u7a33\u6001\uff0c\u6709\u6548\u4fdd\u8bc1\u5fc3\u810fATP\u751f\u6210\u4e0e\u6c27\u5316\u5e94\u6fc0\u4e4b\u95f4\u7684\u52a8\u6001\u5e73\u8861\u3002<\/p>\n<div id=\"F6\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm139983210526288\">\n<div class=\"ts_bar small\" title=\"\u70b9\u51fb\u56fe\u7247\u653e\u5927\"><\/div>\n<p><a class=\"inline_block ts_canvas\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/core\/lw\/2.0\/html\/tileshop_pmc\/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&amp;p=PMC3&amp;id=9551275_fphar-13-930835-g006.jpg\" target=\"tileshopwindow\" rel=\"noopener\"><img decoding=\"async\" class=\"tileshop\" title=\"\u70b9\u51fb\u56fe\u7247\u653e\u5927\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/bin\/fphar-13-930835-g006.jpg\" alt=\"An external file that holds a picture, illustration, etc.Object name is fphar-13-930835-g006.jpg\" \/><\/a><\/div>\n<div id=\"lgnd_F6\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\u56fe6<\/a><\/div>\n<div class=\"caption\">\n<p><strong>\uff08A\uff09<\/strong>\u00a0\u6d4b\u91cf PINK1\u3001Parkin\u3001Tom20 \u548c GAPDH \u7684\u8868\u8fbe\u6c34\u5e73\u00a0<em>\u4f53\u5916<\/em>\u00a0\u7531\u4e16\u754c\u94f6\u884c\u3002\u00a0<strong>(\u4e8c)<\/strong>\u00a0\u8bc4\u4f30\u4e86 p-PINK1\u3001p-Parkin \u548c Tom20 \u7684\u8868\u8fbe\u6c34\u5e73\u3002\u00a0<strong>\uff08C\uff09<\/strong>\u00a0\u7ebf\u7c92\u4f53\u793a\u8e2a\u67d3\u8272\u3002\u00a0<strong>(\u56db)<\/strong>\u00a0\u7535\u5b50\u663e\u5fae\u955c\u3002\u00a0<strong>\uff08\u4e94\uff09<\/strong>\u00a0\u8bc4\u4f30\u4e86 p-AMPK\u3001p-mTOR\u3001p-Akt \u548c p-PI3K \u7684\u8868\u8fbe\u6c34\u5e73\u3002\u00a0<strong>\uff08F\uff09<\/strong>\u00a0\u8865\u5145 Mdivi-1 \u540e H9c2 \u7ec6\u80de\u4e2d ROS \u67d3\u8272\u7684\u5f3a\u5ea6\u3002\u00a0<strong>\uff08G\uff09<\/strong>\u00a0\u8865\u5145 Mdivi-1 \u540e H9c2 \u7ec6\u80de\u4e2d\u7684 ATP \u542b\u91cf\u3002<strong>\uff08H\uff09<\/strong>\u00a0p-AMPK\/t-AMPK\u3001p-mTOR\/t-mTOR\u3001p-Akt\/t-Akt \u548c p-PI3K\/t-PI3K \u7684\u6761\u5f62\u56fe\u3002\u5bf9\u7167\u4e0e Dox\u3001Dox + Mdivi-1 \u4e0e Dox\u3001\u4ee5\u53ca Dox + Brev + Mdivi-1 \u4e0e Dox + Brev\uff1a***<em>p<\/em>\u00a0&lt; 0.0005\uff0c**<em>p<\/em>\u00a0&lt; 0.005\uff0c*<em>p<\/em>\u00a0&lt; 0.05\uff0c\u5e73\u5747\u503c\u00b1SD\u3002\u00a0<em>n<\/em>\u00a0= 6\u20139\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p class=\"p p-last\">\u5f53\u706f\u76cf\u82b1\u7d20\u7684\u8fd9\u79cd\u4f5c\u7528\u88ab Mdivi-1 \u963b\u65ad\u65f6\uff0c\u5fc3\u808c\u7ec6\u80de\u4e2d\u7684 ROS \u6c34\u5e73\u663e\u7740\u589e\u52a0\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\u56fe6F<\/a>\uff09\uff0c\u800c ATP \u4ea7\u91cf\u663e\u7740\u4e0b\u964d\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F6\/\" target=\"figure\" rel=\"noopener\">\u56fe6G<\/a>\uff09\u3002\u6b64\u5916\uff0c\u5fc3\u808c\u7ec6\u80de\u7684\u5b58\u6d3b\u7387\u964d\u4f4e\uff08<a class=\"sec\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#s11\">\u8865\u5145\u56feS6<\/a>\uff09\uff0c\u5e76\u4e14\u706f\u76cf\u82b1\u7d20\u5bf9\u5fc3\u808c\u7ec6\u80de\u7684\u4fee\u590d\u4f5c\u7528\u53d7\u5230\u6291\u5236\u3002\u5f53Dox\u4e0eMdivi-1\u8054\u7528\u65f6\uff0c\u5fc3\u808c\u7ec6\u80deATP\u751f\u6210\u548c\u5b58\u6d3b\u7387\u8fdb\u4e00\u6b65\u964d\u4f4e\uff0cROS\u6c34\u5e73\u5347\u9ad8\uff0c\u5fc3\u808c\u635f\u4f24\u52a0\u5267\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\u7ebf\u7c92\u4f53\u81ea\u566c\u5728 Dox \u8bf1\u5bfc\u7684\u5fc3\u808c\u7ec6\u80de\u635f\u4f24\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002\u5355\u7eaf\u5fc3\u810f\u4ee3\u8c22\u7f51\u7edc\u91cd\u5851\u5e76\u4e0d\u80fd\u5b8c\u5168\u62b5\u6d88\u7ebf\u7c92\u4f53\u635f\u4f24\u5f15\u8d77\u7684\u529f\u80fd\u969c\u788d\uff0c\u706f\u76cf\u82b1\u7d20\u7684\u5fc3\u808c\u4fdd\u62a4\u4f5c\u7528\u4f9d\u8d56\u4e8e\u7cd6\u8102\u4ee3\u8c22\u7684\u8c03\u8282\u548c\u7ebf\u7c92\u4f53\u81ea\u566c\u7684\u6fc0\u6d3b\u3002\u8fd9\u4e5f\u53ef\u80fd\u662fDIC\u53d1\u5c55\u5047\u8bf4\u4e2d\u6ca1\u6709\u8003\u8651\u5fc3\u810f\u4ee3\u8c22\u7f51\u7edc\u8c03\u8282\u7684\u539f\u56e0\u3002\u5efa\u8bae\u5728\u6cbb\u7597Dox\u5f15\u8d77\u7684\u5fc3\u529f\u80fd\u4e0d\u5168\u548c\u5fc3\u529b\u8870\u7aed\u75c7\u72b6\u65f6\uff0c\u9884\u9632\u75be\u75c5\u8fdb\u5c55\u548c\u6062\u590d\u5fc3\u529f\u80fd\u540c\u7b49\u91cd\u8981\uff0c\u8fd9\u66f4\u6709\u5229\u4e8e\u60a3\u8005\u7684\u9884\u540e\u548c\u751f\u6d3b\u8d28\u91cf\u3002<\/p>\n<\/div>\n<div id=\"s3-6\" class=\"sec sec-last\">\n<h3 id=\"s3-6title\">\u706f\u76cf\u82b1\u7d20\u4e0e\u4e73\u817a\u764c\u5316\u7597\u5177\u6709\u534f\u540c\u4f5c\u7528\uff0c\u53ef\u51cf\u8f7b Dox \u7ed9\u836f\u540e\u7684\u708e\u75c7\u5e76\u51cf\u5c11\u514d\u75ab\u6291\u5236\u7ec6\u80de\u6d78\u6da6<\/h3>\n<p class=\"p p-first\">\u6839\u636e\u7ebf\u7c92\u4f53\u8d77\u6e90\u7406\u8bba\uff0c\u7ebf\u7c92\u4f53\u6765\u6e90\u4e8e\u9700\u6c27\u83cc\u7684\u878d\u5408\uff0c\u4e5f\u5c31\u662f\u8bf4\u7ebf\u7c92\u4f53\u5177\u6709\u5916\u6765\u7279\u6027\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B11\" aria-expanded=\"false\" aria-haspopup=\"true\">\u7070\u8272, 2012<\/a>\uff09\u3002\u5f53\u7ebf\u7c92\u4f53\u53d7\u635f\u65f6\uff0c\u635f\u4f24\u76f8\u5173\u5206\u5b50\u6a21\u5f0f (DAMP) \u5c31\u4f1a\u88ab\u89e6\u53d1\uff0c\u4ece\u800c\u6fc0\u6d3b\u4eba\u4f53\u7684\u514d\u75ab\u53cd\u5e94\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B49\" aria-expanded=\"false\" aria-haspopup=\"true\">\u5a01\u5c14\u91d1\u65af\u7b49\u4eba\uff0c2017<\/a>\uff09\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u5047\u8bbe\u706f\u76cf\u82b1\u7d20\u4fc3\u8fdb\u53d7\u635f\u7ebf\u7c92\u4f53\u7684\u6e05\u9664\u5e76\u6709\u52a9\u4e8e\u51cf\u5c11\u708e\u75c7\u3002\u7ed3\u679c\u663e\u793a\uff0c\u706f\u76cf\u82b1\u7d20\u5e72\u9884\u540e\u8840\u6e05\u4e2d\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u767d\u7ec6\u80de\u4ecb\u7d20-1\u03b2\uff08IL-1\u03b2\uff09\u3001IL-6\u3001\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u03b1\uff08TNF-\u03b1\uff09\u7684\u6c34\u5e73\u663e\u7740\u964d\u4f4e\u3002<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F7\/\" target=\"figure\" rel=\"noopener\">\u56fe7A<\/a>\uff09\uff0c\u5fc3\u810f\u7ec4\u7ec7\u7684\u514d\u75ab\u67d3\u8272\u663e\u793a IL-1\u03b2 \u4f4e\u6c34\u5e73\u8868\u8fbe\uff08<a class=\"sec\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#s11\">\u8865\u5145\u56feS7<\/a>\uff09\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\u706f\u76cf\u82b1\u7d20\u53ef\u4ee5\u51cf\u5c11\u708e\u75c7\u56e0\u5b50\u7684\u5206\u6ccc\uff0c\u51cf\u8f7bDox\u66b4\u9732\u5c0f\u9f20\u7684\u708e\u75c7\u53cd\u5e94\u3002\u708e\u75c7\u8c03\u8282\u56e0\u5b50\u548c\u6548\u5e94\u7ec6\u80de\u662f\u80bf\u7624\u5fae\u73af\u5883\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\uff0c\u5728\u708e\u75c7\u4e0e\u80bf\u7624\u7684\u5173\u7cfb\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B9\" aria-expanded=\"false\" aria-haspopup=\"true\">\u57c3\u5229\u7eb3\u592b\u7b49\u4eba\uff0c2013<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B36\" aria-expanded=\"false\" aria-haspopup=\"true\">Sautes-Fridman \u7b49\u4eba\uff0c2019<\/a>\uff09\u3002\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u708e\u75c7\u5177\u6709\u591a\u79cd\u4fc3\u80bf\u7624\u4f5c\u7528\uff0c\u53ef\u4fc3\u8fdb\u6076\u6027\u7ec6\u80de\u7684\u589e\u6b96\u548c\u5b58\u6d3b\u3001\u8840\u7ba1\u751f\u6210\u548c\u8f6c\u79fb\uff1b\u524a\u5f31\u4eba\u4f53\u7684\u83b7\u5f97\u6027\u514d\u75ab\u53cd\u5e94\uff1b\u5e76\u6539\u53d8\u8eab\u4f53\u5bf9\u6fc0\u7d20\u548c\u5316\u7597\u836f\u7269\u7684\u53cd\u5e94\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B14\" aria-expanded=\"false\" aria-haspopup=\"true\">\u827e\u626c\u683c\u7b49\u4eba\uff0c2016<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B28\" aria-expanded=\"false\" aria-haspopup=\"true\">\u7a46\u6069\u548c\u6885\u52d2\uff0c2016<\/a>\uff09\u3002\u706f\u76cf\u82b1\u7d20\u51cf\u5c11 Dox \u6cbb\u7597\u540e\u7684\u708e\u75c7\uff0c\u4f46\u4e0d\u5f71\u54cd Dox \u5bf9\u4e73\u817a\u764c\u7ec6\u80de\u7684\u6740\u4f24\u4f5c\u7528\u00a0<em>\u4f53\u5916<\/em>\u00a0(<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F7\/\" target=\"figure\" rel=\"noopener\">\u56fe7B<\/a>\uff09\u3002\u5b83\u662f\u5426\u6709\u52a9\u4e8e\u963b\u6b62\u708e\u75c7\u7ec6\u80de\u5411\u80bf\u7624\u75c5\u7076\u8fc1\u79fb\uff0c\u7279\u522b\u662f\u5728\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff08TAM\uff09\u7684\u534f\u540c\u6cbb\u7597\u4e2d\uff0c\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u3002 TAM \u662f\u91cd\u8981\u7684\u6d78\u6da6\u6027\u514d\u75ab\u7ec6\u80de\uff0c\u53ef\u4ee5\u89e3\u91ca\u4e73\u817a\u764c\u4e2d\u80bf\u7624\u7ec6\u80de\u7684 50%\u3002\u5c0f\u9f20\u548c\u4eba\u7c7b\u80bf\u7624\u4e2d\u7684 TAM \u548c\u76f8\u5173\u7ec6\u80de\u901a\u5e38\u662f M2 \u5de8\u566c\u7ec6\u80de\uff0c\u5b83\u4eec\u5177\u6709\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u548c\u8840\u7ba1\u751f\u6210\u3001\u589e\u5f3a\u6cbb\u7597\u62b5\u6297\u529b\u5e76\u6291\u5236\u83b7\u5f97\u6027\u514d\u75ab\u7684\u4f5c\u7528\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B6\" aria-expanded=\"false\" aria-haspopup=\"true\">\u9648\u7b49\u4eba\uff0c2019<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B32\" aria-expanded=\"false\" aria-haspopup=\"true\">\u6f58\u7b49\u4eba\uff0c2020<\/a>\uff09\u3002\u51cf\u5c11 TAM \u6d78\u6da6\u6216\u836f\u7269\u8bf1\u5bfc\u7684 TAM \u6e05\u9664\u662f\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u65b0\u5174\u7b56\u7565\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u6784\u5efa\u4e864T1\u4e73\u817a\u764c\u5c0f\u9f20\u6a21\u578b\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F7\/\" target=\"figure\" rel=\"noopener\">\u56fe7C<\/a>\uff09\u3002\u60a3\u6709 4T1 \u80bf\u7624\u7684\u5c0f\u9f20\u00a0<em>\u5c31\u5730<\/em>\u00a0\uff08200\u6beb\u7c73<sup>3<\/sup>\uff09\u88ab\u968f\u673a\u5206\u4e3a3\u7ec4\uff08<em>n<\/em>\u00a0= 5) \u5e76\u6ce8\u5c04\u78f7\u9178\u76d0\u7f13\u51b2\u76d0\u6c34 (PBS)\u3001Dox \u6216 Dox + Brev\u3002 Dox \u548c Brev \u7684\u7ed9\u836f\u5242\u91cf\u4e3a 10 mgkg<sup>\u22121<\/sup>\u00a0\u4f53\u91cd1.4mgkg<sup>\u22121<\/sup>\u00a0\u5206\u522b\u4e3a\u4f53\u91cd\u3002\u6cbb\u7597\u540e7\u5929\u5904\u6b7b\u5c0f\u9f20\uff0c\u6536\u96c6\u80bf\u7624\u7528\u4e8eFCM\u548c\u7ec4\u7ec7\u5b66\u8bc4\u4f30\u3002 Dox + Brev \u6cbb\u7597\u540e\uff0c\u6d78\u6da6\u80bf\u7624\u7684\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de (TAM) \u7684\u6bd4\u4f8b\u51cf\u5c11\u4e86\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F7\/\" target=\"figure\" rel=\"noopener\">\u56fe7D<\/a>\uff09\u3002\u80bf\u7624\u7ec4\u7ec7\u7684\u7ec4\u7ec7\u5b66\u67d3\u8272\u663e\u793a M2 \u8868\u578b\u6807\u8bb0\u7269 CD206 \u7684\u8868\u8fbe\u663e\u7740\u964d\u4f4e\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F7\/\" target=\"figure\" rel=\"noopener\">\u56fe7E<\/a>\uff09\u3002\u4f7f\u7528 Dox + Brev \u6cbb\u7597\u7684\u5c0f\u9f20\u7684\u80bf\u7624\u4f53\u79ef\u663e\u7740\u4f4e\u4e8e\u4ec5\u4f7f\u7528 Dox \u6cbb\u7597\u7684\u5c0f\u9f20\uff08<a class=\"fig-table-link figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F7\/\" target=\"figure\" rel=\"noopener\">\u56fe7F<\/a>\uff09\uff0c\u8868\u660e\u706f\u76cf\u82b1\u7d20\u53ef\u4ee5\u901a\u8fc7\u51cf\u5c11\u708e\u75c7\u548c TAM \u6d78\u6da6\u6765\u6291\u5236\u80bf\u7624\u751f\u957f\u3002<\/p>\n<div id=\"F7\" class=\"fig iconblock whole_rhythm\">\n<div class=\"figure\" data-largeobj=\"\" data-largeobj-link-rid=\"largeobj_idm139983202323296\">\n<div class=\"ts_bar small\" title=\"\u70b9\u51fb\u56fe\u7247\u653e\u5927\"><\/div>\n<p><a class=\"inline_block ts_canvas\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/core\/lw\/2.0\/html\/tileshop_pmc\/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&amp;p=PMC3&amp;id=9551275_fphar-13-930835-g007.jpg\" target=\"tileshopwindow\" rel=\"noopener\"><img decoding=\"async\" class=\"tileshop\" title=\"\u70b9\u51fb\u56fe\u7247\u653e\u5927\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/bin\/fphar-13-930835-g007.jpg\" alt=\"An external file that holds a picture, illustration, etc.Object name is fphar-13-930835-g007.jpg\" \/><\/a><\/div>\n<div id=\"lgnd_F7\" class=\"icnblk_cntnt\">\n<div><a class=\"figpopup\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/figure\/F7\/\" target=\"figure\" rel=\"noopener\">\u56fe7<\/a><\/div>\n<div class=\"caption\">\n<p><strong>\uff08A\uff09<\/strong>\u00a0\u708e\u75c7\u7ec6\u80de\u56e0\u5b50 IL-1\u03b2\u3001IL-6 \u548c TNF-\u03b1 \u7684\u8840\u6e05\u6c34\u5e73\u3002\u00a0<strong>(\u4e8c)<\/strong>\u00a0MCF-7 \u7ec6\u80de\u6d3b\u529b\u00a0<em>\u4f53\u5916<\/em>.\u00a0<strong>\uff08C\uff09<\/strong>\u00a0\u6cbb\u7597\u60a3\u6709\u80bf\u7624\u7684\u5c0f\u9f20\u7684\u793a\u610f\u56fe\u3002\u00a0<strong>(\u56db)<\/strong>\u00a0\u6536\u96c6\u5c0f\u9f20\u80bf\u7624\u7528\u4e8e FCM\u3002\u00a0<strong>\uff08\u4e94\uff09<\/strong>\u00a0M2 \u8868\u578b\u6807\u8bb0 CD206 \u7684\u80bf\u7624\u7ec4\u7ec7\u5b66\u67d3\u8272\u3002\u00a0<strong>\uff08F\uff09<\/strong>\u00a0\u603b\u80bf\u7624\u8d1f\u8377\u7684\u5e73\u5747\u503c\u3002 *<em>p<\/em>\u00a0&lt; 0.0005\u3002 Control \u4e0e Dox\u3001Dexra \u4e0e Dox \u4ee5\u53ca Brev \u4e0e Dox \u5bf9\u6bd4\uff1a***<em>p<\/em>\u00a0&lt; 0.0005\uff0c**<em>p<\/em>\u00a0&lt; 0.005\uff0c*<em>p<\/em>\u00a0&lt; 0.05\uff0c\u5e73\u5747\u503c\u00b1SD\u3002\u00a0<em>n<\/em>\u00a0= 6\u20139\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"s4\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"s4title\" class=\"head no_bottom_margin ui-helper-clearfix\">\u8ba8\u8bba<\/h2>\n<p class=\"p p-first\">\u672c\u7814\u7a76\u63ed\u793a\u7cd6\u8102\u4ee3\u8c22\u529f\u80fd\u969c\u788d\u662f\u84bd\u73af\u7c7b\u836f\u7269\u5f15\u8d77\u5fc3\u810f\u6bd2\u6027\u7684\u91cd\u8981\u9a71\u52a8\u529b\uff0c\u6062\u590d\u5fc3\u810f\u4ee3\u8c22\u3001\u4fc3\u8fdb\u5fc3\u808c\u7cd6\u4ee3\u8c22\u3001\u63d0\u9ad8\u5fc3\u808c\u80fd\u91cf\u8f93\u51fa\u6548\u7387\u662f\u9884\u9632Dox\u5fc3\u810f\u526f\u4f5c\u7528\u7684\u6709\u6548\u65b9\u6cd5\u3002\u5b83\u4eec\u53ef\u4ee5\u4fc3\u8fdb\u7ebf\u7c92\u4f53\u81ea\u566c\uff0c\u6e05\u9664\u53d7\u635f\u7684\u7ebf\u7c92\u4f53\u3002\u51cf\u5c11\u708e\u75c7\u53ef\u589e\u5f3a Dox \u7684\u6297\u764c\u4f5c\u7528\u3002<\/p>\n<p>\u54fa\u4e73\u52a8\u7269\u5fc3\u810f\u4f7f\u7528\u5927\u91cf\u80fd\u91cf\u8fdb\u884c\u6301\u7eed\u6536\u7f29\uff0cATP \u4ea7\u751f\u548c\u5fc3\u810f\u6536\u7f29\u4e4b\u95f4\u7684\u7d27\u5bc6\u8026\u5408\u5bf9\u4e8e\u6b63\u5e38\u7684\u5fc3\u810f\u529f\u80fd\u81f3\u5173\u91cd\u8981\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B3\" aria-expanded=\"false\" aria-haspopup=\"true\">\u4f2f\u7279\u7f57\u548c\u9a6c\u514b\uff0c2018<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B44\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8482\u59c6\u7b49\u4eba\uff0c2018<\/a>\uff09\u3002\u8fd9\u4e2a\u8fc7\u7a0b\u9700\u8981\u5fc3\u810f\u80fd\u91cf\u4ee3\u8c22\u7f51\u7edc\u7684\u7cbe\u786e\u8c03\u8282\u3002\u8be5\u7f51\u7edc\u6700\u663e\u7740\u7684\u7279\u70b9\u662f\u5176\u5bf9\u5404\u79cd\u523a\u6fc0\u7684\u4ee3\u8c22\u7075\u6d3b\u6027\uff0c\u5305\u62ec\u53d1\u80b2\u53d8\u5316\u548c\u8425\u517b\u72b6\u51b5\uff0c\u4ee5\u53ca\u5fc3\u810f\u5728\u6162\u6027\u75c5\u7406\u751f\u7406\u6761\u4ef6\u4e0b\u91cd\u5851\u4ee3\u8c22\u9014\u5f84\u4ee5\u8c03\u8282\u5fc3\u808c\u80fd\u91cf\u548c\u6536\u7f29\u529f\u80fd\u7684\u80fd\u529b\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B3\" aria-expanded=\"false\" aria-haspopup=\"true\">\u4f2f\u7279\u7f57\u548c\u9a6c\u514b\uff0c2018<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B16\" aria-expanded=\"false\" aria-haspopup=\"true\">\u91d1\u7b49\u4eba\uff0c2018<\/a>\uff09\u3002\u8fd9\u79cd\u4ee3\u8c22\u91cd\u5851\u6709\u52a9\u4e8e\u4fdd\u62a4\u5fc3\u810f\u529f\u80fd\u6216\u52a0\u901f\u75be\u75c5\u7684\u8fdb\u5c55\u3002\u5173\u4e8e\u5fc3\u810f\u75be\u75c5\u7684\u7814\u7a76\u5f88\u591a\uff0c\u5982\u5fc3\u810f\u80a5\u5927\u3001\u5fc3\u529b\u8870\u7aed\u7b49\uff0c\u4f46\u5bf9DIC\u7684\u7814\u7a76\u5374\u5f88\u5c11\u3002\u5148\u524d\u7684\u7814\u7a76\u91cd\u70b9\u662f ROS \u4ea7\u751f\u548c\u62d3\u6251\u5f02\u6784\u9176 II-\u03b2 \u9776\u5411\uff0c\u8fd9\u4f1a\u5bfc\u81f4 DNA \u635f\u4f24\u3001\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u548c Ca<sup>2+<\/sup>\u00a0\u5904\u7406\u4e0d\u5f53\u3002\u7136\u800c\uff0c\u6e05\u9664 ROS \u7684\u94c1\u87af\u5408\u5242\u548c\u62d3\u6251\u5f02\u6784\u9176 II-\u03b2 \u8c03\u8282\u5242 dexra \u672a\u80fd\u63d0\u4f9b\u663e\u7740\u7684\u76ca\u5904\uff0c\u8fd9\u8868\u660e\u8fd8\u6d89\u53ca\u5176\u4ed6\u56e0\u7d20\u3002 Dox\u5982\u4f55\u8c03\u8282\u5fc3\u808c\u4ee3\u8c22\u7f51\u7edc\u3001\u8be5\u4ee3\u8c22\u7f51\u7edc\u7684\u91cd\u5851\u5982\u4f55\u5f71\u54cd\u5fc3\u810f\u7684\u80fd\u91cf\u8f93\u51fa\u6548\u7387\u4ee5\u53caDox\u662f\u5426\u4f1a\u4fc3\u8fdb\u5fc3\u810f\u6bd2\u6027\u4ecd\u7136\u672a\u77e5\u3002\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0c\u8102\u8d28\u8fc7\u6c27\u5316\u79ef\u7d2f\u5f15\u8d77\u7684\u5fc3\u808c\u7ec6\u80de\u94c1\u6b7b\u4ea1\u5728DIC\u7684\u8fdb\u5c55\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u8868\u660eDox\u66b4\u9732\u7684\u5fc3\u808c\u7ec6\u80de\u6709\u589e\u5f3a\u8102\u8d28\u4ee3\u8c22\u7684\u503e\u5411\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B52\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c22\u7b49\u4eba\uff0c2021<\/a>;\u00a0<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B17\" aria-expanded=\"false\" aria-haspopup=\"true\">\u559c\u591a\u65b9\u7b49\u4eba\uff0c2022<\/a>\uff09\u3002\u6211\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u8fdb\u4e00\u6b65\u9610\u660e\uff0cDox \u8bf1\u5bfc\u7684\u5fc3\u810f\u6bd2\u6027\u662f\u7531\u8461\u8404\u7cd6\u548c\u8102\u8d28\u4ee3\u8c22\u5931\u8c03\u7684\u6076\u6027\u53cd\u9988\u5faa\u73af\u9a71\u52a8\u7684\uff0c\u4ece\u800c\u5bfc\u81f4\u8017\u6c27\u91cf\u589e\u52a0\u3001\u80fd\u91cf\u4ea7\u751f\u6548\u7387\u4f4e\u4e0b\u548c\u6c27\u5316\u5e94\u6fc0\u6c34\u5e73\u589e\u52a0\u3002<\/p>\n<p class=\"p p-last\">\u706f\u76cf\u82b1\u7d20\u662f\u6211\u56fd\u6cbb\u7597\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u5e94\u7528\u6700\u5e7f\u6cdb\u7684\u7ecf\u5178\u836f\u7269\uff0c\u88ab\u5217\u5165\u300a\u4e2d\u56fd\u836f\u5178\u300b\u548c\u56fd\u5bb6\u57fa\u672c\u836f\u7269\u76ee\u5f55\uff0c\u662f\u6211\u56fd\u533b\u9662\u6025\u6551\u7684\u57fa\u672c\u836f\u7269\u3002\u6211\u4eec\u7684\u7814\u7a76\u53d1\u73b0\u706f\u76cf\u82b1\u7d20\u901a\u8fc7\u8c03\u8282\u8840\u6e05\u7d20-\u8840\u7cd6-\u5fc3\u808c AKT \u56de\u8def\u3001\u91cd\u5851\u5fc3\u808c\u80fd\u91cf\u4ee3\u8c22\u3001\u589e\u52a0\u8461\u8404\u7cd6\u5229\u7528\u7387\u548c\u51cf\u5c11\u8102\u8d28\u6c27\u5316\u6765\u63d0\u9ad8 ATP \u4ea7\u751f\u6548\u7387\u3002\u7f13\u89e3\u56e0Dox\u66b4\u9732\u5bfc\u81f4\u5fc3\u810f\u5927\u91cf\u8102\u8d28\u4ee3\u8c22\u4e0d\u5145\u5206\u800c\u9020\u6210\u7684\u4f4eATP\u4ea7\u751f\u3001\u9ad8\u8017\u6c27\u91cf\u548c\u9ad8\u6c27\u5316\u5e94\u6fc0\u7684\u5f71\u54cd\uff0c\u964d\u4f4eAMPK\u7684\u8868\u8fbe\uff0c\u963b\u65ad\u5fc3\u810f\u8fc7\u5ea6\u8102\u8d28\u6444\u53d6\u7684\u6076\u6027\u5faa\u73af\u3002\u5fc3\u808c\uff0c\u5e76\u51cf\u7f13 DIC \u7684\u53d1\u5c55\uff08<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B19\" aria-expanded=\"false\" aria-haspopup=\"true\">\u79d1\u7ef4\u5947\u548c\u7530\uff0c2011<\/a>\uff09\u3002\u6b64\u5916\uff0c\u6211\u4eec\u7684\u7ed3\u679c\u8868\u660e\uff0c\u8840\u6e05\u7d20\u53ef\u80fd\u4f5c\u4e3a\u80f0\u5c9b\u7d20\u7684\u8865\u5145\u5206\u652f\u6765\u8c03\u8282\u8840\u7cd6\uff0c\u5728\u75c5\u7406\u6761\u4ef6\u4e0b\u4e3a\u5fc3\u810f\u548c\u5176\u4ed6\u91cd\u8981\u5668\u5b98\u63d0\u4f9b\u8840\u7cd6\u3002\u8840\u6e05\u7d20\u5bf9\u8840\u7cd6\u8c03\u8282\u5177\u6709\u77db\u76fe\u7684\u4f5c\u7528\u3002\u4e00\u65b9\u9762\uff0c\u5b83\u4e0e\u80f0\u5c9b\u7d20\u76f8\u4e92\u4f5c\u7528\uff0c\u964d\u4f4e\u8840\u7cd6\u6c34\u5e73\uff1b\u53e6\u4e00\u65b9\u9762\uff0c\u5b83\u4f1a\u5bfc\u81f4\u809d\u810f\u548c\u9aa8\u9abc\u808c\u4ee5\u5916\u7684\u7ec4\u7ec7\u5438\u6536\u8461\u8404\u7cd6\u5e76\u63d0\u9ad8\u8840\u7cd6\u6c34\u5e73\u3002\u8fd9\u8868\u660e\u964d\u4f4e\u5916\u5468\u8840\u6e05\u6c34\u5e73\uff08\u4f8b\u5982\u901a\u8fc7\u706f\u76cf\u82b1\u7d20\u6cbb\u7597\uff09\u53ef\u80fd\u6709\u52a9\u4e8e\u5668\u5b98\u5229\u7528\u8461\u8404\u7cd6\u3002\u6b64\u5916\uff0c\u706f\u76cf\u82b1\u7d20\u5bf9\u5fc3\u810f\u6bd2\u6027\u7684\u6291\u5236\u4f5c\u7528\u4f9d\u8d56\u4e8e\u7ebf\u7c92\u4f53\u81ea\u566c\u7684\u589e\u5f3a\uff0c\u5728Dox\u5f15\u8d77\u7684\u5fc3\u810f\u635f\u4f24\u4e2d\uff0c\u5355\u72ec\u7684\u5fc3\u810f\u4ee3\u8c22\u91cd\u5851\u5e76\u4e0d\u80fd\u5bfc\u81f4\u79ef\u7d2f\u7684\u7ebf\u7c92\u4f53\u7684\u6e05\u9664\u3002\u706f\u76cf\u82b1\u7d20\u8bf1\u5bfc\u81ea\u566c\u00a0<em>\u4f53\u5185<\/em>\u00a0\u901a\u8fc7PINK1\/Parkin\u901a\u8def\u6062\u590d\u5fc3\u808c\u7ebf\u7c92\u4f53\u7a33\u6001\uff0c\u51cf\u8f7b\u963f\u9709\u7d20\u5f15\u8d77\u7684\u5fc3\u810f\u6bd2\u6027\u3002\u8003\u8651\u5230\u81ea\u566c\u7684\u6fc0\u6d3b\u53c2\u4e0e\u591a\u79cd\u75be\u75c5\u7684\u53d1\u751f\u548c\u53d1\u5c55\uff0c\u706f\u76cf\u82b1\u7d20\u53ef\u80fd\u6210\u4e3a\u7ebf\u7c92\u4f53\u81ea\u566c\u76f8\u5173\u75be\u75c5\u7684\u5019\u9009\u836f\u7269\uff0c\u5177\u6709\u5f88\u597d\u7684\u4e34\u5e8a\u5e94\u7528\u4ef7\u503c\u3002\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\u706f\u76cf\u82b1\u7d20\u5bf9\u80bf\u7624\u7684\u751f\u957f\u548c\u80bf\u7624\u7ec6\u80de\u7684\u751f\u7269\u5b66\u884c\u4e3a\u5177\u6709\u4e00\u5b9a\u7684\u6291\u5236\u4f5c\u7528\u3002<a class=\"bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#B55\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53f6\u7b49\u4eba\uff0c2020<\/a>\uff09\u3002\u8be5\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u706f\u76cf\u82b1\u7d20\u53ef\u4ee5\u9884\u9632\u4e73\u817a\u764c\u80bf\u7624\u6a21\u578b\u4e2d\u963f\u9709\u7d20\u5f15\u8d77\u7684\u5fc3\u529f\u80fd\u969c\u788d\uff0c\u5e76\u901a\u8fc7\u6d88\u9664\u53d7\u635f\u7684\u7ebf\u7c92\u4f53\u6765\u964d\u4f4e\u708e\u75c7\u56e0\u5b50\u6c34\u5e73\u548c\u514d\u75ab\u6291\u5236\u5de8\u566c\u7ec6\u80de\u6d78\u6da6\uff0c\u4e0e\u963f\u9709\u7d20\u7684\u6297\u80bf\u7624\u4f5c\u7528\u5177\u6709\u534f\u540c\u4f5c\u7528\u3002\u706f\u76cf\u82b1\u7d20\u901a\u8fc7\u63d0\u4f9b\u764c\u75c7\u7684\u53cc\u91cd\u6cbb\u7597\u4f18\u52bf\u6765\u51cf\u5c11\u80bf\u7624\u751f\u957f\uff0c\u9632\u6b62\u84bd\u73af\u7c7b\u836f\u7269\u7684\u5fc3\u810f\u6bd2\u6027\u3002\u706f\u76cf\u82b1\u7d20\u53ef\u9884\u9632\u84bd\u73af\u7c7b\u836f\u7269\u5f15\u8d77\u7684\u5fc3\u810f\u6bd2\u6027\uff0c\u5e76\u4e0e\u84bd\u73af\u7c7b\u836f\u7269\u53d1\u6325\u534f\u540c\u6297\u80bf\u7624\u4f5c\u7528\uff0c\u5177\u6709\u826f\u597d\u7684\u4e34\u5e8a\u5e94\u7528\u4ef7\u503c\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"ack-a.m.a\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"ack-a.m.atitle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u81f4\u8c22<\/h2>\n<div class=\"sec\">\n<p>\u4f5c\u8005\u611f\u8c22\u4e2d\u56fd\u9752\u5c9b\u5927\u5b66\u9644\u5c5e\u533b\u9662\u764c\u75c7\u7814\u7a76\u6240 W-SS \u7684\u539f\u59cb\u8349\u6848\u51c6\u5907\u548c\u6570\u636e\u7ba1\u7406\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<div id=\"s5\" class=\"tsec bk-sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"s5title\" class=\"head no_bottom_margin ui-helper-clearfix\">\u6570\u636e\u53ef\u7528\u6027\u58f0\u660e<\/h2>\n<p class=\"p p-first-last\">\u7814\u7a76\u4e2d\u63d0\u51fa\u7684\u539f\u59cb\u8d21\u732e\u5305\u542b\u5728\u6587\u7ae0\/<a class=\"sec\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#s11\">\u8865\u5145\u6750\u6599<\/a>;\u8fdb\u4e00\u6b65\u8be2\u95ee\u53ef\u76f4\u63a5\u8054\u7cfb\u76f8\u5e94\u4f5c\u8005\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"s6\" class=\"tsec bk-sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"s6title\" class=\"head no_bottom_margin ui-helper-clearfix\">\u9053\u5fb7\u58f0\u660e<\/h2>\n<p class=\"p p-first-last\">\u6d89\u53ca\u4eba\u7c7b\u53c2\u4e0e\u8005\u7684\u7814\u7a76\u5f97\u5230\u4e86\u9752\u5c9b\u5927\u5b66\u9644\u5c5e\u533b\u9662\u4f26\u7406\u59d4\u5458\u4f1a\u7684\u5ba1\u67e5\u548c\u6279\u51c6\u3002\u60a3\u8005\/\u53c2\u4e0e\u8005\u63d0\u4f9b\u4e86\u53c2\u4e0e\u672c\u7814\u7a76\u7684\u4e66\u9762\u77e5\u60c5\u540c\u610f\u4e66\u3002\u52a8\u7269\u7814\u7a76\u7ecf\u9752\u5c9b\u5927\u5b66\u533b\u5b66\u9662\u4f26\u7406\u59d4\u5458\u4f1a\u5ba1\u67e5\u6279\u51c6\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"s7\" class=\"tsec bk-sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"s7title\" class=\"head no_bottom_margin ui-helper-clearfix\">\u4f5c\u8005\u8d21\u732e<\/h2>\n<p class=\"p p-first-last\">M-JL \u548c W-SS \u64cd\u4f5c\u4e86\u6240\u6709\u5b9e\u9a8c\uff0c\u5206\u6790\u4e86\u6570\u636e\uff0c\u5e76\u64b0\u5199\u4e86\u521d\u7a3f\u3002 Y-KZ\u5206\u6790\u4e86\u6570\u636e\u5e76\u5199\u51fa\u4e86\u521d\u7a3f\u3002 YY\u5206\u6790\u4e86\u6570\u636e\u3002 QL \u5206\u6790\u5e76\u89e3\u91ca\u4e86\u52a8\u7269\u7684\u6570\u636e\u3002 Y-ZG\u8fdb\u884c\u52a8\u7269\u5b9e\u9a8c\u3002 TY\u8fdb\u884c\u4e86\u52a8\u7269\u5b9e\u9a8c\u3002 D-MX - \u5ba1\u9605\u5e76\u7f16\u8f91\u4e86\u624b\u7a3f\u3002\u6240\u6709\u4f5c\u8005\u9605\u8bfb\u5e76\u8ba4\u53ef\u7684\u7ec8\u7a3f\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"s8\" class=\"tsec bk-sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"s8title\" class=\"head no_bottom_margin ui-helper-clearfix\">\u8d44\u91d1<\/h2>\n<p class=\"p p-first-last\">\u8be5\u7814\u7a76\u5f97\u5230\u4e86\u9752\u5c9b\u5e02\u80bf\u7624\u533b\u9662\u8d44\u52a9\u673a\u6784\u548c\u9752\u5c9b\u5e02\u535a\u58eb\u540e\u5e94\u7528\u7814\u7a76\u9879\u76ee\uff08\u7f16\u53f7\uff1aRZ2100005362\uff09\u7684\u4e13\u9879\u8d44\u52a9\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"s9\" class=\"tsec bk-sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"s9title\" class=\"head no_bottom_margin ui-helper-clearfix\">\u5229\u76ca\u51b2\u7a81<\/h2>\n<p class=\"p p-first-last\">\u4f5c\u8005\u58f0\u660e\uff0c\u8be5\u7814\u7a76\u662f\u5728\u4e0d\u5b58\u5728\u4efb\u4f55\u53ef\u80fd\u88ab\u89c6\u4e3a\u6f5c\u5728\u5229\u76ca\u51b2\u7a81\u7684\u5546\u4e1a\u6216\u8d22\u52a1\u5173\u7cfb\u7684\u60c5\u51b5\u4e0b\u8fdb\u884c\u7684\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"s10\" class=\"tsec bk-sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"s10title\" class=\"head no_bottom_margin ui-helper-clearfix\">\u51fa\u7248\u5546\u5907\u6ce8<\/h2>\n<p class=\"p p-first-last\">\u672c\u6587\u4e2d\u8868\u8fbe\u7684\u6240\u6709\u4e3b\u5f20\u4ec5\u4ee3\u8868\u4f5c\u8005\u7684\u4e3b\u5f20\uff0c\u5e76\u4e0d\u4e00\u5b9a\u4ee3\u8868\u5176\u9644\u5c5e\u7ec4\u7ec7\u6216\u51fa\u7248\u5546\u3001\u7f16\u8f91\u548c\u5ba1\u7a3f\u4eba\u7684\u4e3b\u5f20\u3002\u672c\u6587\u4e2d\u53ef\u80fd\u8bc4\u4f30\u7684\u4efb\u4f55\u4ea7\u54c1\u6216\u5176\u5236\u9020\u5546\u53ef\u80fd\u63d0\u51fa\u7684\u58f0\u660e\u5747\u672a\u5f97\u5230\u51fa\u7248\u5546\u7684\u4fdd\u8bc1\u6216\u8ba4\u53ef\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div id=\"s11\" class=\"tsec bk-sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"s11title\" class=\"head no_bottom_margin ui-helper-clearfix\">\u8865\u5145\u6750\u6599<\/h2>\n<p class=\"p p-first\">\u672c\u6587\u7684\u8865\u5145\u6750\u6599\u53ef\u4ee5\u5728\u7ebf\u627e\u5230\uff1a\u00a0<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.930835\/full#supplementary-material\" target=\"_blank\" rel=\"noopener\" data-ga-action=\"click_feat_suppl\">https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2022.930835\/full#supplementary-material<\/a><\/p>\n<div id=\"SM1\" class=\"sec suppmat\">\n<div id=\"media-a.m.h.c.a\" class=\"sup-box half_rhythm\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/bin\/Table1.DOCX\" data-ga-action=\"click_feat_suppl\">\u5355\u51fb\u6b64\u5904\u83b7\u53d6\u5176\u4ed6\u6570\u636e\u6587\u4ef6\u3002<\/a><sup>\uff082.5M\uff0cDOCX\uff09<\/sup><\/div>\n<div><\/div>\n<\/div>\n<\/div>\n<div id=\"ref-list-a.m.i\" class=\"tsec sec\">\n<div class=\"goto jig-ncbiinpagenav-goto-container\"><a class=\"tgt_dark page-toc-label jig-ncbiinpagenav-goto-heading\" title=\"\u8f6c\u5230\u6b64\u9875\u9762\u7684\u5176\u4ed6\u90e8\u5206\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#\" aria-expanded=\"false\" aria-haspopup=\"true\">\u53bb\uff1a<\/a><\/div>\n<h2 id=\"ref-list-a.m.ititle\" class=\"head no_bottom_margin ui-helper-clearfix\">\u53c2\u8003<\/h2>\n<p>&nbsp;<\/p>\n<div id=\"reference-list\" class=\"ref-list-sec sec\">\n<ul class=\"back-ref-list\">\n<li id=\"B1\"><span class=\"mixed-citation\">Alexandre J.\u3001Cautela J.\u3001Ederhy S.\u3001Damaj GL\u3001Salem JE\u3001Barlesi F. \u7b49\u3002 \uff082020\uff09\u3002\u00a0<span class=\"ref-title\">\u4e0e\u764c\u75c7\u6cbb\u7597\u76f8\u5173\u7684\u5fc3\u8840\u7ba1\u6bd2\u6027\uff1a\u7f8e\u56fd\u548c\u6b27\u6d32\u5fc3\u810f\u80bf\u7624\u5b66\u6307\u5357\u7684\u5b9e\u7528\u65b9\u6cd5<\/span>.\u00a0<span class=\"ref-journal\">J. Am.\u5fc3\u810f\u534f\u4f1a\u3002<\/span>\u00a0<span class=\"ref-vol\">9<\/span>\u00a0(<span class=\"ref-iss\">18<\/span>\uff09\uff0ce018403\u3002 10.1161\/JAHA.120.018403\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7727003\/\">PMC \u514d\u8d39\u6587\u7ae0<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32893704\">\u8003\u7814<\/a>] [<a href=\"https:\/\/doi.org\/10.1161%2FJAHA.120.018403\" target=\"_blank\" rel=\"noopener noreferrer\">\u4ea4\u53c9\u5f15\u7528<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J.+Am.+Heart+Assoc.&amp;title=Cardiovascular+toxicity+related+to+cancer+treatment:+A+pragmatic+approach+to+the+American+and+European+cardio-oncology+guidelines&amp;author=J.+Alexandre&amp;author=J.+Cautela&amp;author=S.+Ederhy&amp;author=G.+L.+Damaj&amp;author=J.+E.+Salem&amp;volume=9&amp;issue=18&amp;publication_year=2020&amp;pages=e018403&amp;pmid=32893704&amp;doi=10.1161\/JAHA.120.018403&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B2\"><span class=\"mixed-citation\">\u4f2f\u683c M.\u3001\u683c\u96f7 JA\u3001\u7f57\u65af BL (2009)\u3002\u00a0<span class=\"ref-title\">\u8840\u6e05\u7d20\u7684\u6269\u5c55\u751f\u7269\u5b66<\/span>.\u00a0<span class=\"ref-journal\">\u5b89\u52aa\u3002\u533b\u5b66\u535a\u58eb\u3002<\/span>\u00a0<span class=\"ref-vol\">60<\/span>\uff0c355\u2013366\u3002 10.1146\/annurev.med.60.042307.110802\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5864293\/\">PMC \u514d\u8d39\u6587\u7ae0<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19630576\">\u8003\u7814<\/a>] [<a href=\"https:\/\/doi.org\/10.1146%2Fannurev.med.60.042307.110802\" target=\"_blank\" rel=\"noopener noreferrer\">\u4ea4\u53c9\u5f15\u7528<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Annu.+Rev.+Med.&amp;title=The+expanded+biology+of+serotonin&amp;author=M.+Berger&amp;author=J.+A.+Gray&amp;author=B.+L.+Roth&amp;volume=60&amp;publication_year=2009&amp;pages=355-366&amp;pmid=19630576&amp;doi=10.1146\/annurev.med.60.042307.110802&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B3\"><span class=\"mixed-citation\">\u4f2f\u7279\u7f57\u00b7E.\uff0c\u9a6c\u514b\u00b7C.\uff082018\uff09\u3002\u00a0<span class=\"ref-title\">\u5fc3\u529b\u8870\u7aed\u7684\u4ee3\u8c22\u91cd\u5851<\/span>.\u00a0<span class=\"ref-journal\">\u7eb3\u7279\u3002\u5361\u8fea\u5965\u5c14\u7267\u5e08\u3002<\/span>\u00a0<span class=\"ref-vol\">15<\/span>\u00a0(<span class=\"ref-iss\">8<\/span>\uff09\uff0c457\u2013470\u3002 10.1038\/s41569-018-0044-6 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29915254\">\u8003\u7814<\/a>] [<a href=\"https:\/\/doi.org\/10.1038%2Fs41569-018-0044-6\" target=\"_blank\" rel=\"noopener noreferrer\">\u4ea4\u53c9\u5f15\u7528<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Nat.+Rev.+Cardiol.&amp;title=Metabolic+remodelling+in+heart+failure&amp;author=E.+Bertero&amp;author=C.+Maack&amp;volume=15&amp;issue=8&amp;publication_year=2018&amp;pages=457-470&amp;pmid=29915254&amp;doi=10.1038\/s41569-018-0044-6&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B4\"><span class=\"mixed-citation\">Carmean CM\u3001Yokoi N.\u3001Takahashi H.\u3001Oduori OS\u3001Kang C.\u3001Kanakawa A. \u7b49\u3002 \uff082019\uff09\u3002\u00a0<span class=\"ref-title\">\u7837\u901a\u8fc7\u80f0\u817a\u03b2\u7ec6\u80de\u4e2d\u7684\u8461\u8404\u7cd6\u919b\u9178\u5316\u6539\u53d8\u8840\u6e05\u7d20\u4ee3\u8c22<\/span>.\u00a0<span class=\"ref-journal\">\u662f\u3002 J.\u751f\u7406\u5b66\u3002\u5185\u5206\u6ccc\u3002\u5143\u6570\u636e\u3002<\/span>\u00a0<span class=\"ref-vol\">316<\/span>\u00a0(<span class=\"ref-iss\">3<\/span>\uff09\uff0cE464\u2013E74\u3002 10.1152\/ajpendo.00302.2018\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6459295\/\">PMC \u514d\u8d39\u6587\u7ae0<\/a>]<\/span>\u00a0[<a 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target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B26\"><span class=\"mixed-citation\">Lopaschuk GD\u3001Karwi QG\u3001Tian R.\u3001Wende AR\u3001Abel ED (2021)\u3002\u00a0<span class=\"ref-title\">\u5fc3\u529b\u8870\u7aed\u65f6\u7684\u5fc3\u810f\u80fd\u91cf\u4ee3\u8c22<\/span>.\u00a0<span class=\"ref-journal\">\u5faa\u73af\u3002\u8d44\u6e90\u3002<\/span>\u00a0<span class=\"ref-vol\">128<\/span>\u00a0(<span class=\"ref-iss\">10<\/span>\uff09\uff0c1487\u20131513\u3002 10.1161\/CIRCRESAHA.121.318241\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8136750\/\">PMC \u514d\u8d39\u6587\u7ae0<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33983836\">\u8003\u7814<\/a>] [<a href=\"https:\/\/doi.org\/10.1161%2FCIRCRESAHA.121.318241\" target=\"_blank\" rel=\"noopener 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aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B28\"><span class=\"mixed-citation\">\u7a46\u6069 DH\uff0c\u6885\u52d2 AL (2016)\u3002\u00a0<span class=\"ref-title\">\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684 Ido\uff1a\u708e\u75c7\u3001\u53cd\u8c03\u8282\u548c\u8010\u53d7\u6027<\/span>.\u00a0<span class=\"ref-journal\">\u8d8b\u52bf\u514d\u75ab\u5b66\u3002<\/span>\u00a0<span class=\"ref-vol\">37<\/span>\u00a0(<span class=\"ref-iss\">3<\/span>\uff09\uff0c193-207\u3002 10.1016\/j.it.2016.01.002\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4916957\/\">PMC \u514d\u8d39\u6587\u7ae0<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26839260\">\u8003\u7814<\/a>] [<a href=\"https:\/\/doi.org\/10.1016%2Fj.it.2016.01.002\" target=\"_blank\" rel=\"noopener noreferrer\">\u4ea4\u53c9\u5f15\u7528<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" 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aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B30\"><span class=\"mixed-citation\">Nhu NT\uff0cLi Q.\uff0cLiu Y.\uff0cXu J.\uff0cXiao SY\uff0cLee SD\uff082021\uff09\u3002\u00a0<span class=\"ref-title\">mdivi-1 \u5bf9\u8111\u5352\u4e2d\u540e\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u4e2d\u795e\u7ecf\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u548c\u7ebf\u7c92\u4f53\u4ecb\u5bfc\u7684\u7ec6\u80de\u51cb\u4ea1\u7684\u5f71\u54cd\uff1a\u4e34\u5e8a\u524d\u7814\u7a76\u7684\u7cfb\u7edf\u8bc4\u4ef7<\/span>.\u00a0<span class=\"ref-journal\">\u6b63\u9762\u3002\u6469\u5c14\u3002\u795e\u7ecf\u79d1\u5b66\u3002<\/span>\u00a0<span class=\"ref-vol\">14<\/span>, 778569.10.3389\/fnmol.2021.778569\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8740201\/\">PMC \u514d\u8d39\u6587\u7ae0<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35002619\">\u8003\u7814<\/a>] [<a href=\"https:\/\/doi.org\/10.3389%2Ffnmol.2021.778569\" target=\"_blank\" rel=\"noopener noreferrer\">\u4ea4\u53c9\u5f15\u7528<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Front.+Mol.+Neurosci.&amp;title=Effects+of+mdivi-1+on+neural+mitochondrial+dysfunction+and+mitochondria-mediated+apoptosis+in+ischemia-reperfusion+injury+after+stroke:+A+systematic+review+of+preclinical+studies&amp;author=N.+T.+Nhu&amp;author=Q.+Li&amp;author=Y.+Liu&amp;author=J.+Xu&amp;author=S.+Y.+Xiao&amp;volume=14&amp;publication_year=2021&amp;pages=778569&amp;pmid=35002619&amp;doi=10.3389\/fnmol.2021.778569&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B31\"><span class=\"mixed-citation\">Okaty BW\u3001Commons KG\u3001Dymecki SM (2019)\u3002\u00a0<span class=\"ref-title\">\u62e5\u62b1 5-HT 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aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B32\"><span class=\"mixed-citation\">\u6f58Y.\uff0c\u4e8eY.\uff0c\u738bX.\uff0c\u5f20T.(2020)\u3002\u00a0<span class=\"ref-title\">\u80bf\u7624\u514d\u75ab\u4e2d\u7684\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de<\/span>.\u00a0<span class=\"ref-journal\">\u6b63\u9762\u3002\u514d\u75ab\u5b66\u3002<\/span>\u00a0<span class=\"ref-vol\">11<\/span>, 583084.10.3389\/fimmu.2020.583084\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7751482\/\">PMC \u514d\u8d39\u6587\u7ae0<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33365025\">\u8003\u7814<\/a>] [<a href=\"https:\/\/doi.org\/10.3389%2Ffimmu.2020.583084\" target=\"_blank\" rel=\"noopener noreferrer\">\u4ea4\u53c9\u5f15\u7528<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Front.+Immunol.&amp;title=Tumor-associated+macrophages+in+tumor+immunity&amp;author=Y.+Pan&amp;author=Y.+Yu&amp;author=X.+Wang&amp;author=T.+Zhang&amp;volume=11&amp;publication_year=2020&amp;pages=583084&amp;pmid=33365025&amp;doi=10.3389\/fimmu.2020.583084&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B33\"><span class=\"mixed-citation\">\u666e\u5c14 LP\u3001\u9ea6\u514b\u52b3\u5fb7 KF (2021)\u3002\u00a0<span class=\"ref-title\">\u7ebf\u7c92\u4f53\u81ea\u566c\u5728\u80bf\u7624\u53d1\u751f\u548c\u8f6c\u79fb\u4e2d\u7684\u4f5c\u7528<\/span>.\u00a0<span class=\"ref-journal\">\u7ec6\u80de\u3002\u6469\u5c14\u3002\u751f\u547d\u79d1\u5b66\u3002<\/span>\u00a0<span class=\"ref-vol\">78<\/span>\u00a0(<span class=\"ref-iss\">8<\/span>\uff09\uff0c3817\u20133851\u3002 10.1007\/s00018-021-03774-1\u00a0<span 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aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B51\"><span class=\"mixed-citation\">\u590f G.\uff0c\u97e9 Y.\uff0c\u5b5f F.\uff0c\u4f55 Y.\uff0cSrisai D.\uff0cFarias M.\uff0c\u7b49\u3002 \uff082021\uff09\u3002\u00a0<span class=\"ref-title\">\u901a\u8fc7 GABA \u548c\u8840\u6e05\u7d20\u795e\u7ecf\u56de\u8def\u76f8\u4e92\u63a7\u5236\u80a5\u80d6\u548c\u7126\u8651\u6291\u90c1\u75c7<\/span>.\u00a0<span class=\"ref-journal\">\u6469\u5c14\u3002\u7cbe\u795e\u75c5\u5b66<\/span>\u00a0<span class=\"ref-vol\">26<\/span>\u00a0(<span class=\"ref-iss\">7<\/span>\uff09\uff0c2837\u20132853\u3002 10.1038\/s41380-021-01053-w\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8505263\/\">PMC \u514d\u8d39\u6587\u7ae0<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33767348\">\u8003\u7814<\/a>] [<a href=\"https:\/\/doi.org\/10.1038%2Fs41380-021-01053-w\" target=\"_blank\" rel=\"noopener noreferrer\">\u4ea4\u53c9\u5f15\u7528<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Mol.+Psychiatry&amp;title=Reciprocal+control+of+obesity+and+anxiety-depressive+disorder+via+a+GABA+and+serotonin+neural+circuit&amp;author=G.+Xia&amp;author=Y.+Han&amp;author=F.+Meng&amp;author=Y.+He&amp;author=D.+Srisai&amp;volume=26&amp;issue=7&amp;publication_year=2021&amp;pages=2837-2853&amp;pmid=33767348&amp;doi=10.1038\/s41380-021-01053-w&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B52\"><span class=\"mixed-citation\">\u8c22S.\uff0c\u5b59W.\uff0c\u5f20C.\uff0c\u8463B.\uff0c\u6768J.\uff0c\u4fafM.\uff0c\u7b49\u3002 \uff082021\uff09\u3002\u00a0<span 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href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=ACS+Nano&amp;title=Metabolic+control+by+heat+stress+determining+cell+fate+to+ferroptosis+for+effective+cancer+therapy&amp;author=S.+Xie&amp;author=W.+Sun&amp;author=C.+Zhang&amp;author=B.+Dong&amp;author=J.+Yang&amp;volume=15&amp;issue=4&amp;publication_year=2021&amp;pages=7179-7194&amp;pmid=33861924&amp;doi=10.1021\/acsnano.1c00380&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B53\"><span class=\"mixed-citation\">Yabut JM\u3001Crane JD\u3001Green AE\u3001Keating DJ\u3001Khan WI\u3001Steinberg GR (2019)\u3002\u00a0<span class=\"ref-title\">\u8840\u6e05\u7d20\u5728\u8c03\u8282\u65b0\u9648\u4ee3\u8c22\u4e2d\u7684\u65b0\u4f5c\u7528\uff1a\u5bf9\u53e4\u8001\u5206\u5b50\u7684\u65b0\u5f71\u54cd<\/span>.\u00a0<span class=\"ref-journal\">\u5185\u5206\u6ccc\u3002\u7267\u5e08\u3002<\/span>\u00a0<span 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rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B54\"><span class=\"mixed-citation\">\u5c71\u672c T.\uff0c\u4f50\u91ce M. (2022)\u3002\u00a0<span class=\"ref-title\">\u5fc3\u529b\u8870\u7aed\u65f6\u5fc3\u808c\u8102\u80aa\u9178\u4ee3\u8c22\u7d0a\u4e71<\/span>.\u00a0<span class=\"ref-journal\">\u56fd\u9645\u3002 J.\u83ab\u5c14\u3002\u79d1\u5b66\u3002<\/span>\u00a0<span class=\"ref-vol\">23<\/span>\u00a0(<span class=\"ref-iss\">2<\/span>), 996.10.3390\/ijms23020996\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8779056\/\">PMC \u514d\u8d39\u6587\u7ae0<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35055179\">\u8003\u7814<\/a>] [<a href=\"https:\/\/doi.org\/10.3390%2Fijms23020996\" target=\"_blank\" rel=\"noopener noreferrer\">\u4ea4\u53c9\u5f15\u7528<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Int.+J.+Mol.+Sci.&amp;title=Deranged+myocardial+fatty+acid+metabolism+in+heart+failure&amp;author=T.+Yamamoto&amp;author=M.+Sano&amp;volume=23&amp;issue=2&amp;publication_year=2022&amp;pages=996&amp;pmid=35055179&amp;doi=10.3390\/ijms23020996&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B55\"><span class=\"mixed-citation\">\u53f6\u9759\uff0c\u9ad8\u660e\uff0c\u90ed\u6653\uff0c\u5f20\u6167\uff0c\u59dc\u82b3\uff082020\uff09\u3002\u00a0<span class=\"ref-title\">\u706f\u76cf\u82b1\u7d20\u901a\u8fc7\u8c03\u8282 PAQR4 \u4ecb\u5bfc\u7684 PI3K\/Akt \u901a\u8def\u6291\u5236\u524d\u5217\u817a\u764c\u7684\u751f\u957f\u548c\u8f6c\u79fb<\/span>.\u00a0<span class=\"ref-journal\">\u751f\u7269\u533b\u5b66\u3002\u836f\u5242\u5e08\u3002<\/span>\u00a0<span class=\"ref-vol\">127<\/span>, 110223.10.1016\/j.biopha.2020.110223 [<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32413672\">\u8003\u7814<\/a>] [<a href=\"https:\/\/doi.org\/10.1016%2Fj.biopha.2020.110223\" target=\"_blank\" rel=\"noopener noreferrer\">\u4ea4\u53c9\u5f15\u7528<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Biomed.+Pharmacother.&amp;title=Breviscapine+suppresses+the+growth+and+metastasis+of+prostate+cancer+through+regulating+PAQR4-mediated+PI3K\/Akt+pathway&amp;author=J.+Ye&amp;author=M.+Gao&amp;author=X.+Guo&amp;author=H.+Zhang&amp;author=F.+Jiang&amp;volume=127&amp;publication_year=2020&amp;pages=110223&amp;pmid=32413672&amp;doi=10.1016\/j.biopha.2020.110223&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B56\"><span class=\"mixed-citation\">Zemdegs J.\u3001Quesseveur G.\u3001Jarriault D.\u3001Penicaud L.\u3001Fioramonti X.\u3001Guiard BP (2016)\u3002\u00a0<span class=\"ref-title\">\u9ad8\u8102\u80aa\u996e\u98df\u5f15\u8d77\u7684\u4ee3\u8c22\u7d0a\u4e71\u4f1a\u635f\u5bb3\u5c0f\u9f20\u7684 5-HT \u529f\u80fd\u548c\u7126\u8651\u6837\u884c\u4e3a<\/span>.\u00a0<span class=\"ref-journal\">Br\u3002 J.Pharmacol\u3002<\/span>\u00a0<span class=\"ref-vol\">173<\/span>\u00a0(<span class=\"ref-iss\">13<\/span>\uff09\uff0c2095\u20132110\u3002 10.1111\/bph.13343\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4908198\/\">PMC \u514d\u8d39\u6587\u7ae0<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26472268\">\u8003\u7814<\/a>] [<a href=\"https:\/\/doi.org\/10.1111%2Fbph.13343\" target=\"_blank\" rel=\"noopener noreferrer\">\u4ea4\u53c9\u5f15\u7528<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Br.+J.+Pharmacol.&amp;title=High-fat+diet-induced+metabolic+disorders+impairs+5-HT+function+and+anxiety-like+behavior+in+mice&amp;author=J.+Zemdegs&amp;author=G.+Quesseveur&amp;author=D.+Jarriault&amp;author=L.+Penicaud&amp;author=X.+Fioramonti&amp;volume=173&amp;issue=13&amp;publication_year=2016&amp;pages=2095-2110&amp;pmid=26472268&amp;doi=10.1111\/bph.13343&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<li id=\"B57\"><span class=\"mixed-citation\">Zhu Y.\u3001Pereira RO\u3001O&#039;Neill BT\u3001Riehle C.\u3001Ilkun O.\u3001Wende AR \u7b49\u3002 \uff082013\uff09\u3002\u00a0<span class=\"ref-title\">\u5fc3\u810f PI3K-Akt \u635f\u5bb3\u80f0\u5c9b\u7d20\u523a\u6fc0\u7684\u8461\u8404\u7cd6\u6444\u53d6\uff0c\u4e0e mTORC1 \u548c GLUT4 \u6613\u4f4d\u65e0\u5173<\/span>.\u00a0<span class=\"ref-journal\">\u6469\u5c14\u3002\u5185\u5206\u6ccc\u3002<\/span>\u00a0<span class=\"ref-vol\">27<\/span>\u00a0(<span class=\"ref-iss\">1<\/span>\uff09\uff0c172\u2013184\u3002 10.1210\/me.2012-1210\u00a0<span class=\"nowrap\">[<a class=\"int-reflink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3545208\/\">PMC \u514d\u8d39\u6587\u7ae0<\/a>]<\/span>\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23204326\">\u8003\u7814<\/a>] [<a href=\"https:\/\/doi.org\/10.1210%2Fme.2012-1210\" target=\"_blank\" rel=\"noopener noreferrer\">\u4ea4\u53c9\u5f15\u7528<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Mol.+Endocrinol.&amp;title=Cardiac+PI3K-Akt+impairs+insulin-stimulated+glucose+uptake+independent+of+mTORC1+and+GLUT4+translocation&amp;author=Y.+Zhu&amp;author=R.+O.+Pereira&amp;author=B.+T.+O%27Neill&amp;author=C.+Riehle&amp;author=O.+Ilkun&amp;volume=27&amp;issue=1&amp;publication_year=2013&amp;pages=172-184&amp;pmid=23204326&amp;doi=10.1210\/me.2012-1210&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">\u8c37\u6b4c\u5b66\u672f<\/a>]<\/span><\/span><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551275\/#:~:text=Interestingly%2C%20breviscapine%20increases%20the%20efficiency,heart%20and%20reducing%20lipid%20oxidation\">\u6765\u6e90<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u5e7f\u8c31\u6297\u764c\u836f\u7269\u963f\u9709\u7d20\uff08Dox\uff09\u5177\u6709\u8f83\u9ad8\u7684\u5fc3\u810f\u6bd2\u6027\u53d1\u751f\u7387\uff0c\u4e25\u91cd\u5f71\u54cd\u8be5\u836f\u7269\u7684\u4e34\u5e8a\u5e94\u7528\u548c\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u8bc4\u4f30\u4e86 Dox 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